Relevant bibliographies by topics / Indole Heterocyclic compounds

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Indole Heterocyclic compounds'

Author: Grafiati
Published: 4 June 2021
Last updated: 17 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Indole Heterocyclic compounds.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Indole Heterocyclic compounds"

1

Boraei, Ahmed T. A., Ahmed A. M. Sarhan, Sammer Yousuf, and Assem Barakat. "Synthesis of a New Series of Nitrogen/Sulfur Heterocycles by Linking Four Rings: Indole; 1,2,4-Triazole; Pyridazine; and Quinoxaline." Molecules 25, no. 3 (January 21, 2020): 450. http://dx.doi.org/10.3390/molecules25030450.

Full text
Abstract:
A new series of nitrogen and sulfur heterocyclic systems were efficiently synthesized by linking the following four rings: indole; 1,2,4-triazole; pyridazine; and quinoxaline hybrids. The strength of the acid that catalyzes the condensation of 4-amino-5-(1H-indol-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 1 with aromatic aldehydes controlled the final product. Reflux in glacial acetic acid yielded Schiff bases 2–6, whereas concentrated HCl in ethanol resulted in a cyclization product at C-3 of the indole ring to create indolo-triazolo-pyridazinethiones 7–16. This fascinating cyclization approach was applicable with a wide range of aromatic aldehydes to create the target cyclized compounds in excellent yield. Additionally, the coupling of the new indolo-triazolo-pyridazinethiones 7–13 with 2,3-bis(bromomethyl)quinoxaline, as a linker in acetone and K2CO3, yielded 2,3-bis((5,6-dihydro-14H-indolo[2,3-d]-6-aryl-[1,2,4-triazolo][4,3-b]pyridazin-3 ylsulfanyl)methyl)quinoxalines 19–25 in a high yield. The formation of this new class of heterocyclic compounds in high yields warrants their use for further research. The new compounds were characterized using nuclear magnetic resonance (NMR) and mass spectral analysis. Compound 6 was further confirmed by the single crystal X-ray diffraction technique.
APA, Harvard, Vancouver, ISO, and other styles
2

Mir, Reyaz Hassan, Roohi Mohi-ud-din, Taha Umair Wani, Mohammad Ovais Dar, Abdul Jaleel Shah, Bashir Lone, Chawla Pooja, and Mubashir Hussain Masoodi. "Indole: A Privileged Heterocyclic Moiety in the Management of Cancer." Current Organic Chemistry 25, no. 6 (March 26, 2021): 724–36. http://dx.doi.org/10.2174/1385272825666210208142108.

Full text
Abstract:
Heterocyclic are a class of compounds that are intricately entwined into life processes. Almost more than 90% of marketed drugs carry heterocycles. Synthetic chemistry, in turn, allocates a cornucopia of heterocycles. Among the heterocycles, indole, a bicyclic structure consisting of a six-membered benzene ring fused to a five-membered pyrrole ring with numerous pharmacophores that generate a library of various lead molecules. Due to its profound pharmacological profile, indole got wider attention around the globe to explore it fully in the interest of mankind. The current review covers recent advancements on indole in the design of various anti-cancer agents acting by targeting various enzymes or receptors, including (HDACs), sirtuins, PIM kinases, DNA topoisomerases, and σ receptors.
APA, Harvard, Vancouver, ISO, and other styles
3

Sonawane, Ratnamala P., and Rahul R. Tripathi. "The Chemistry and Synthesis of 1H-indole-2,3-dione (Isatin) and its Derivatives." International Letters of Chemistry, Physics and Astronomy 12 (September 2013): 30–36. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.12.30.

Full text
Abstract:
Isatins are synthetically versatile substrates, where they can be used for the synthesis of a large variety of heterocyclic compounds. In this, a convenient method has been developed for the conversion of Indoles into Isatins and some heterocyclic derivative were synthesised such as 5- nitro-1H-indole-2,3-dione, 2-methylquinoline-4-carboxylic acid which may be used as raw material for drug synthesis. The general process utilizes the effective method for synthesis of Isatin from Indole is bromination and oxidation with an N-bromosuccinimide-dimethyl sulfoxide reagent. The nitration of Isatin at C-5 takes place by using KNO3, conc. H2SO4, 2-methylquinoline-4-caboxylic acid are usually obtained from pfitzinger reaction.
APA, Harvard, Vancouver, ISO, and other styles
4

El-Sawy, Eslam, Fatma Bassyouni, Sherifa Abu-Bakr, Hanaa Rady, and Mohamed Abdlla. "Synthesis and biological activity of some new 1-benzyl and 1-benzoyl-3-heterocyclic indole derivatives." Acta Pharmaceutica 60, no. 1 (March 1, 2010): 55–71. http://dx.doi.org/10.2478/v10007-010-0004-0.

Full text
Abstract:
Synthesis and biological activity of some new 1-benzyl and 1-benzoyl-3-heterocyclic indole derivativesStarting from 1-benzyl- (2a) and 1-benzoyl-3-bromoacetyl indoles (2b) new heterocyclic, 2-thioxoimidazolidine (4a, b), imidazolidine-2,4-dione (5a, b), pyrano(2,3-d)imida-zole (8a, band9a, b), 2-substituted quinoxaline (11a, b-17a, b) and triazolo(4,3-a)quinoxaline derivatives (18a, band19a, b) were synthesized and evaluated for their antimicrobial and anticancer activities. Antimicrobial activity screening performed with concentrations of 0.88, 0.44 and 0.22 μg mm-2showed that 3-(1-substituted indol-3-yl)quinoxalin-2(1H)ones (11a, b) and 2-(4-methyl piperazin-1-yl)-3-(1-substituted indol-3-yl) quinoxalines (15a, b) were the most active of all the tested compounds towardsP. aeruginosa, B. cereusandS. aureuscompared to the reference drugs cefotaxime and piperacillin, while 2-chloro-3-(1-substituted indol-3-yl)quinoxalines (12a, b) were the most active against C.albicanscompared to the reference drug nystatin. On the other hand, 2-chloro-3-(1-benzyl indol-3-yl) quinoxaline12adisplay potent efficacy against ovarian cancer xenografts in nude mice with tumor growth suppression of 100.0 ± 0.3 %.
APA, Harvard, Vancouver, ISO, and other styles
5

Sulthana, Shaheen, and P. Pandian. "A review on Indole and Benzothiazole derivatives its importance." Journal of Drug Delivery and Therapeutics 9, no. 1-s (February 15, 2019): 505–9. http://dx.doi.org/10.22270/jddt.v9i1-s.2358.

Full text
Abstract:
In recent years heterocyclic compounds analogues and derivatives have attracted wide attention due to their useful biological and pharmacological properties. Indole, Benzothiazole and its analogs are versatile substrates, which can be used for the synthesis of numerous heterocyclic compounds. Indole, Benzothiazole and its derivatives are used in organic synthesis and they are used in evaluating new product that possesses different biological activities. Hence, their extensive structural modification has result in different analogues of Indole and Benzothiazole derivatives depicting wide range of biological and pharmacological activities such as antiviral, anticonvulsant, anti-inflammatory, analgesic, antimicrobial and anticancer. This review article literature survey summarizes the synthesis and pharmacological activities of Indole, Benzothiazole and its derivatives. Keywords: Indole, Benzothiazole, antiviral, anticonvulsant, anti-inflammatory, analgesic, antimicrobial and anticancer
APA, Harvard, Vancouver, ISO, and other styles
6

Guan, Zong, Jan C. Namyslo, Martin H. H. Drafz, Martin Nieger, and Andreas Schmidt. "Dimerisation, rhodium complex formation and rearrangements of N-heterocyclic carbenes of indazoles." Beilstein Journal of Organic Chemistry 10 (April 10, 2014): 832–40. http://dx.doi.org/10.3762/bjoc.10.79.

Full text
Abstract:
Deprotonation of indazolium salts at low temperatures gives N-heterocyclic carbenes of indazoles (indazol-3-ylidenes) which can be trapped as rhodium complexes (X-ray analysis). In the absence of Rh, the indazol-3-ylidenes spontaneously dimerize under ring cleavage of one of the N,N-bonds and ring closure to an indazole–indole spiro compound which possesses an exocyclic imine group. The E/Z isomers of the imines can be separated by column chromatography when methanol is used as eluent. We present results of a single crystal X-ray analysis of one of the E-isomers, which equilibrate in solution as well as in the solid state. Heating of the indazole–indole spiro compounds results in the formation of quinazolines by a ring-cleavage/ring-closure sequence (X-ray analysis). Results of DFT calculations are presented.
APA, Harvard, Vancouver, ISO, and other styles
7

Ali, Imran, Sofi Danish Mukhtar, Ming Fa Hsieh, Zeid A. Alothman, and Abdulrahman Alwarthan. "Facile synthesis of indole heterocyclic compounds based micellar nano anti-cancer drugs." RSC Advances 8, no. 66 (2018): 37905–14. http://dx.doi.org/10.1039/c8ra07060a.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Ashram, Muhammad, Ahmed Al-Mustafa, Wael A. Al-Zereini, Firas F. Awwadi, and Islam Ashram. "A convenient one-pot approach to the synthesis of novel pyrazino[1,2-a]indoles fused to heterocyclic systems and evaluation of their biological activity as acetylcholinesterase inhibitors." Zeitschrift für Naturforschung B 76, no. 5 (May 1, 2021): 303–12. http://dx.doi.org/10.1515/znb-2020-0205.

Full text
Abstract:
Abstract Pyrazino[1,2-a]indoles fused with various heterocycles, such as oxazolidine, oxazinane, imidazolidine, hexahydropyrimidine and benzimidazole, were synthesized transition metal-free by domino reactions which involved the condensation of 1-(2-bromoethyl)-3-chloro-1H-indole-2-carbaldehydes 28–31 with various nucleophilic amines, resulting in the formation of two new interesting fused heterocycles. The anticholinesterase, antioxidant and antibacterial activities of the compounds were evaluated. Acetylcholinesterase (AChE) inhibitory activities were tested by Ellman’s assay, antioxidant activities were detected using the 2,2-azinobis[3-ethylbenzthiazoline]-6-sulfonic acid (ABTS•+) free-radical scavenging method and antibacterial activities were determined by agar diffusion tests. The oxazolo-pyrazino[1,2-a]indoles (8, 10), the oxazino-pyrazino[1,2-a]indoles (16, 18, 19), the pyrimido-pyrazino[1,2-a]indole (22), and the benzoimidazo-pyrazino[1,2-a]indole (27) possessed the highest inhibitory activity against AChE with IC50 values in the range 20–40 μg mL−1. The oxazolo-pyrazino[1,2-a]indoles (8, 9), the imidazo-pyrazino[1,2-a]indoles (12, 13), and the benzoimidazo-pyrazino[1,2-a]indole (24) revealed the highest antioxidant values with IC50 values less than 300 μg mL−1. However, the oxazolo-pyrazino[1,2-a]indole (11) and imidazo-pyrazino[1,2-a]indoles (12, 13) exhibited weak to moderate bioactivities against all tested Gram-positive bacteria, namely Staphylococcus aureus, Bacillus subtilis and Bacillus cereus.
APA, Harvard, Vancouver, ISO, and other styles
9

Kumar, Devendra, Sahil Sharma, Sourav Kalra, Gurpreet Singh, Vikramdeep Monga, and Bhupinder Kumar. "Medicinal Perspective of Indole Derivatives: Recent Developments and Structure-Activity Relationship Studies." Current Drug Targets 21, no. 9 (July 28, 2020): 864–91. http://dx.doi.org/10.2174/1389450121666200310115327.

Full text
Abstract:
Heterocyclic compounds play a significant role in various biological processes of the human body and many of them are in clinical use due to their diverse, chemical and biological properties. Among these, indole is one of the most promising pharmacologically active molecules. Due to its chemical reactivity, indole has been willingly modified to obtain a variety of new lead molecules, which has been successfully utilized to obtained novel drug candidates for the treatment of different pharmacological diseases. Indole-based compounds such as vincristine (anticancer), reserpine (antihypertensive), amedalin (antidepressant) and many more describe the medicinal and pharmacological importance of the indole in uplifting human life. In this review, we compiled various reports on indole derivatives and their biological significance, including antifungal, antiprotozoal, antiplatelet, anti- Alzheimer’s, anti-Parkinson’s, antioxidant and anticancer potential from 2015 onwards. In addition, structure-activity relationship studies of the different derivatives have been included. We have also discussed novel synthetic strategies developed during this period for the synthesis of different indole derivatives. We believe that this review article will provide comprehensive knowledge about the medicinal importance of indoles and will help in the design and synthesis of novel indole-based molecules with high potency and efficacy.
APA, Harvard, Vancouver, ISO, and other styles
10

Black, DS, N. Chaichit, BM Gatehouse, and GI Moss. "Unusual Formation of New Indole-Containing Heterocyclic Ring Systems." Australian Journal of Chemistry 40, no. 12 (1987): 1965. http://dx.doi.org/10.1071/ch9871965.

Full text
Abstract:
The oxazinoindoletrione (3) underwent reaction with aqueous ammonia in methanol or ethanol to yield the polycyclic methyl or ethyl esters (4) and (5) respectively. Reaction of trione (3) with gaseous ammonia in dry ethanol gave the aminobenzodiazepinone (7). This compound lost ammonia on heating in toluene to give compound (11) and in the presence of methanol or ethanol gave the methyl or ethyl esters (9) and (10) respectively. The structures of compounds (4), (7) and (10) were all established by X-ray crystallography.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Indole Heterocyclic compounds"

1

Engqvist, Robert. "Syntheses of some tri- and tetracyclic heterocycles containing an indole moiety /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-161-X/.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Somphol, Kittiya Chemistry Faculty of Science UNSW. "Synthesis of new heterocyclic structures based on indoles." Awarded by:University of New South Wales. Chemistry, 2007. http://handle.unsw.edu.au/1959.4/40829.

Full text
Abstract:
Novel indolo-macrocycles have been generated from the attempts to synthesise bis-indolo-cyclotriveratrylenes by the condensation of I, I'-diindolyl-3,3'-dimethanols catalysed by p-toluenesulfonic acid. The addition of substituents on indoles led to enhanced solubilities of the macrocycles. Nine- and six-membered ring compounds have been synthesized from the acid-catalysed reaction of I,I'-diindolyl compounds and aryl aldehydes. Some reactions of these compounds and the attempted synthesis of 2,2' diindolylmethanes from the cyclic compounds have also been described. The electrophilic substitution reactions of 3-substituted 4,6-dimethoxyindole 2,6-dimethanols and 3-substituted 4,6-dimethoxyindole-7 and 2-carbaldehydes and I-substituted indoles afforded triindolyl dialdehydes. The wriation of substituents at C-7 of indole-7-aldehydes and at C-2 of indole-2-aldehydes has also been discussed. Reaction of the hydroxymethylindole and 1,2-di(indol-I-ylmethyl)benzene gave a new macrocycle. Substitution reactions of 2,2???-diindolylmethane-7,7'-dimethanol and indole-7- and 2-aldehydes gave tetraindolyl dialdehydes. Sodium borohydride reduction of tri- and tetra-indolyl dialdehydes gave tri- and tetra-indolyl dimethanols respectively. Acid-catalysed reactions of tri- and tetra-indolyl dimethanols afforded only calix[3] and [4]indoles respectively when all substituents at C-3 of indoles were aryl groups. New conditions for indole based imine synthesis have been established Macrocyclic imine formation from mono-, di-, tri and tetra-indolyl dialdehydes has been investigated. Reactions of indole-3, 7-dialdehydes and short chain diamines (1,2-diaminoethane, 1,2-diaminobenzene and 1,6-diaminohexane) gave mixtures while the reactions with long chain diamines (1,10 diaminodecane and 1,12-diaminododecane) gave monoindolyl macrocyclic imines. Reaction of indole-2, 7-dialdehydes and short chain diamines afforded diindolyl macrocyclic imines with head-tail structures, and the 2,7';2',2";7",2'''-Tetraindole-7 ,7"'-dialdehyde underwent cyclisation with triindolyl dialdehydes and 1,6-diaminohexane afforded triindolyl macrocyclic imines. 1,2 diaminoethane while the 2,3 ';1',1 ";3 ",2"'-tetraindole-7,7"'-dialdehydes underwent imine, with its precise structure established by X-ray crystallography. Reaction of of 1,3-di(indol-l-ylmethyl)benzene and 1,2 diaminoethane yielded a new macrocyclic reactions with long chain diamines yielded monoindolyl macrocyclic imines. Reaction ring closure with 1,2 diaminoethane and 1,6-diaminohexane.
APA, Harvard, Vancouver, ISO, and other styles
3

Banini, Serge R. "Palladium-catalyzed syntheses of indoles, pyrroloindoles, quinolines a base-mediated formation of N-alkoxyindoles, and progress toward the first total synthesis of echinosulfone A /." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5710.

Full text
Abstract:
Thesis (Ph. D.)--West Virginia University, 2008.
Title from document title page. Document formatted into pages; contains xv, 275 p. : ill. Includes abstract. Includes bibliographical references (p. 107-113).
APA, Harvard, Vancouver, ISO, and other styles
4

Gu, Ji-Dong. "Biodegradation of pesticide and indolic compounds under methanogenic conditions." Diss., Virginia Tech, 1991. http://hdl.handle.net/10919/39831.

Full text
Abstract:
Degradability of atrazine, cyanazine, and dicamba under methanogenic conditions was evaluated using serum bottle microcosms containing wetland soil inocula obtained from three different sites. Pesticides were monitored by high-performance liquid chromatography (HPLC) and the production of methane was measured with a gas chromatograph (GC). Dicamba was the most susceptible to degradation in the microcosms, followed by cyanazine. Atrazine was not degraded in the wetland soils. A dicamba-degrading methanogenic consortium was enriched from one of the initial wetland soil microcosms (Lawnes). Dicamba degradation was further examined using this consortium. Net methane production suggested that the aromatic ring was not degraded. Rates of dicamba degradation were enhanced with addition of 0.2 % yeast extract. Dicamba degradation was accomplished within 4 days compared to 22 days without yeast extract addition. The inability of the consortium to degrade the benzenoid ring was confirmed when no ¹⁴CO₂ was produced upon addition of [U-¹⁴C]dicamba to the cultures. Analysis of culture filtrate by HPLC revealed the presence of a possible metabolite that was aromatic in character.
Ph. D.
APA, Harvard, Vancouver, ISO, and other styles
5

Pchalek, Karin Chemistry Faculty of Science UNSW. "Design and synthesis of new ligands and heterocycles from activated indoles." Awarded by:University of New South Wales. School of Chemistry, 2004. http://handle.unsw.edu.au/1959.4/20584.

Full text
Abstract:
For the purpose of incorporating indoles into organometallic complexes for catalysis, as well as in the generation of new heterocyclic systems, various reactions have been carried out at C2, C6 and C7 of the indole system. In order to achieve this, 3-substituted 4,6-dimethoxyindoles and 6-hydroxy- 4-methoxyindoles were necessary as starting materials. Consequently, a lithium-bromide-templated one-pot procedure for the synthesis of some 3-substituted 4,6-dimethoxyindoles and a selective demethylation procedure for 3-substituted 6-hydroxy-4-methoxyindoles were developed. Various kinds of novel methylene-bridged bi-, tri-, and tetradentate pyridyl-indole ligands were synthesised via Vilsmeier-Haack, Friedel-Crafts or electrophilic addition reactions on the indole heterocycle. However, their metal complexing properties were generally weak and variable. Nevertheless, some of the tridentate pyridylindole ligands showed strong anion binding to halides, whereas a remarkable ligand transformation occurred with a bidentate 2-pyridylindole ligand and zinc(II), giving a substituted indolo[2,3-c]pyrrolo-[3,2,1-ij]quinoline system. Two new types of tetradentate Schiff base ligands were prepared from 2-formyl-indoles and 7-formyl-6-hydroxyindoles, and diamines. These preformed ligands were reacted with first- and second-row transition metals to give neutral metal complexes. Novel heterocyclic systems such as 4H-pyrrolo[3,2,1-ij]quinolines, 3H-pyrrolo-[1,2-a]indoles, and 1H-furo[2,3-g]indoles were synthesised from 2-formyl-, 7-formyl-, and 6-hydroxyindoles, utilising mainly intra-molecular Wittig reactions, Claisen-Schmidt condensations or acid- and base-catalysed cyclisations. A common feature of the prepared 4H-pyrrolo[3,2,1-ij]quinolines and 3H-pyrrolo-[1,2-a]indoles was their intense fluorescent character, which was examined as well.
APA, Harvard, Vancouver, ISO, and other styles
6

Souchet, Michel. "Synthese de la (+) anticapsine et d'analogues structuraux : evaluation de leurs proprietes biologiques." Paris 6, 1988. http://www.theses.fr/1988PA066545.

Full text
Abstract:
Synthese du compose du titre et de ses derives perhydro indoliques via la synthese stereoselective d'alcools allyliques. Etude de l'activite inhibatrice des composes synthetises sur la glucosamine synthetase et sur l'enzyme de conversion de l'angiotensine
APA, Harvard, Vancouver, ISO, and other styles
7

Berkous, Rabiaa. "Greffage de modèles du NADH sur deux nouveaux supports insolubles. Synthèse et réactivité d'un modèle du NADH en série indolo (2,3-b)-pyridine : réduction de substrats non activés." Rouen, 1994. http://www.theses.fr/1994ROUES042.

Full text
Abstract:
Le greffage de réactifs modèles du NADH a été réalisé sur deux nouveaux supports: un matériau mixte silice-polymère et un polymère acrylique à chiralité intrinsèque. Dans les deux cas, la réduction de substrats classiques a été possible. Avec le second support, une induction asymétrique a été observée. Afin d'effectuer la réduction de substrats non activés en présence d'acides de Lewis capables d'activer de tels substrats, un modèle en série indolo (2,3-)pyridinique a été synthétisé. Il est stable et possède une réactivité élevée. Il est le premier modèle du NADH à avoir permis la réduction quasi quantitative de l'acétophénone. Il a également permis de réduire une large gamme de cétones non activées. Le modèle chiral de la même série a réduit l'acétophénone et le phénylglyoxylate de méthyle avec des excès énantiomériques intéressants. Un modèle non chiral en présence d'acides de Lewis chiraux a aussi permis d'observer une induction asymétrique
APA, Harvard, Vancouver, ISO, and other styles
8

Koulibaly, Issa. "Automatisation et optimisation de la synthèse du ((pyridyl-4)-2 ethyl)-3 indole, précurseur d'un antidépresseur." Paris 6, 1986. http://www.theses.fr/1986PA066413.

Full text
Abstract:
Dans le cadre des recherches concernant l'application des techniques d'automatisation et des méthodes d'optimisation, sur les procédés de fabrications industrielles de produits pharmaceutiques, nous avons choisi l'automatisation et l'optimisation de la synthèse d'un précurseur de l'indalpine, qui est un produit pharmaceutique important par ses propriétés d'antidépresseur. Nous montrons, dans la première partie de ce travail, qu'il est possible d'automatiser, à l'échelle du laboratoire, et pour un cout réduit, une synthèse organique complexe à l'aide d'un automate de bas de gamme et de capteurs et actionneurs adéquats, que l'automatisation nécessite une bonne description du mode opératoire; pour cela, nous avons utilisé le langage grafcet afin de structurer le mode opératoire industriel. Dans la deuxième partie, nous prouvons qu'il est aussi possible d'améliorer le rendement d'une synthèse organique en établissant la fonction réponse et en l'optimisant pour obtenir les coordonnées de l'optimum. Pour la synthèse concernée dans ce travail, le gain de rendement a été de 22 points.
APA, Harvard, Vancouver, ISO, and other styles
9

Kerbal, Abdelali. "Cycloaddition de diarylnitrilimines et d'azides sur diverses énones et énamines dérivées d'indadones et de tétralones : Regiochimie, diasteréochimie et transformation des cycloadduits." Besançon, 1988. http://www.theses.fr/1988BESA2038.

Full text
Abstract:
La cycloaddition dipolaire-1,3 des diarylnitrilimines sur diverses enones a double-liaison dipolarophile juxtacyclique est regiospecifique. Lorsque le dipolarophile présente deux faces diastereotopiques, l'approche dipole-dipolarographie se fait du côté le moins encombré : - de façon diastereospecifique sur les enones dérivées de l'indanone-1 substituée ou de la tetralone-1 substituée lorsque ces dernières portent en -3 ou -4 un substituant occupant une position axiale - de facon diastereoselective sur les enones dérivées de la tetralone-1 portant un substituant en -4 qui peut adopter une disposition équatoriale. Ces résultats qui mettent en évidence l'importance des facteurs conformationnels, sont généraux et ont pu être étendus aux cas d'autres enones dérivées des chromanones et isothiochromanone
APA, Harvard, Vancouver, ISO, and other styles
10

Ferroud, Clotilde. "Étude de la réaction de Diels-Adler intra et intermoléculaire sous haute pression : application à la synthèse stéréosélective d'alcaloïdes de l'indole du groupe des yohimbanes." Paris 6, 1986. http://www.theses.fr/1986PA066023.

Full text
Abstract:
Le schéma de synthèse repose sur une unité bicyclique, précurseur direct des unités (d,e) du squelette pentacyclique. Cet intermédiaire est basé sur une réaction de Diels-Alder sous haute pression, utilisant la cycloaddition de diènes de structure donneur-accepteur 1,4 avec une lactone insaturée comme diénophile. La synthèse du système pentacyclique est exposée à partir de cet intermédiaire clé.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Indole Heterocyclic compounds"

1

service), SpringerLink (Online, ed. Heterocyclic Scaffolds II: Reactions and Applications of Indoles. Berlin, Heidelberg: Springer-Verlag Berlin Heidelberg, 2011.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

1957-, Kumar M., and Gupta V. 1966-, eds. Heterocyclic chemistry. Berlin: Springer, 1998.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
3

Sumpter, W. C., and F. M. Miller. Heterocyclic Compounds with Indole and Carbazole Systems. Wiley & Sons, Incorporated, John, 2009.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

Gribble, Gordon W. Heterocyclic Scaffolds II : : Reactions and Applications of Indoles. Springer, 2010.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

Gribble, Gordon W. Heterocyclic Scaffolds II : : Reactions and Applications of Indoles. Springer, 2012.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

Gupta, Radha R., Vandana Gupta, and Mahendra Kumar. Heterocyclic Chemistry II: Five-Membered Heterocycles (Heterocyclic Chemistry). Springer, 1999.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

Houlihan, William J. Indoles, Part 2. Wiley & Sons, Incorporated, John, 2009.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

Houlihan, William J. Indoles, Part 1. Wiley & Sons, Incorporated, John, 2009.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

Houlihan, William J. Indoles, Part 3. Wiley & Sons, Incorporated, John, 2009.

Find full text
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Indole Heterocyclic compounds"

1

Wu, Yong-Jin. "New Indole-Containing Medicinal Compounds." In Topics in Heterocyclic Chemistry, 1–29. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/7081_2010_37.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Rush, Kent. "Oxidized Nitrogen Derivatives of Indole and Indoline." In Chemistry of Heterocyclic Compounds: A Series Of Monographs, 539–605. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186930.ch5.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Remers, William A. "Indole Aldehydes and Ketones." In Chemistry of Heterocyclic Compounds: A Series Of Monographs, 357–527. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186947.ch2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Brown, Robert K. "Synthesis of the Indole Nucleus." In Chemistry of Heterocyclic Compounds: A Series Of Monographs, 227–558. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186923.ch2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Spande, Thomas F. "Hydroxyindoles, Indole Alcohols, and Indolethiols." In Chemistry of Heterocyclic Compounds: A Series Of Monographs, 1–355. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186947.ch1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Parry, Ronald J. "Biosynthesis of Compounds Containing an Indole Nucleus." In Chemistry of Heterocyclic Compounds: A Series Of Monographs, 1–64. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186930.ch1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Smith, Lowell R. "Alkyl, Alkenyl and Alkynyl Indoles." In Chemistry of Heterocyclic Compounds: A Series Of Monographs, 65–126. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186930.ch2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Powers, James C. "Haloindoles and Organometallic Derivatives of Indoles." In Chemistry of Heterocyclic Compounds: A Series Of Monographs, 127–78. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186930.ch3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Troxler, F. "Chemistry of Indoles Carrying Basic Functions." In Chemistry of Heterocyclic Compounds: A Series Of Monographs, 179–537. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186930.ch4.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Remers, W. A. "Properties and Reactions of Indoles, Isoindoles, and Their Hydrogenated Derivatives." In Chemistry of Heterocyclic Compounds: A Series Of Monographs, 1–226. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186923.ch1.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Indole Heterocyclic compounds"

1

Manabe, S., H. Yanagisawa, S. Ishikawa, Y. Kitagawa, K. Tohyama, S. Abe, and O. Wada. "TRYPTOPHAN PYROLYSIS PRODUCTS FOUND IN COOKED FOODS INHIBIT HUMAN PLATELET AGGREGATION BY INHIBITING CYCLOOXYGENASE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643402.

Full text
Abstract:
Humans are exposed to numerous toxic compounds in foods. During the past decade, several carcinogenic heterocyclic amines have been reported to be present in the cooked foods. Recently, we reported that some of the carcinogenic heterocyclic amines isolated from foods were present in human plasma. In order to know the effects of the carcinogens isolated from foods on the cell function, we investigated the effects of the carcinogenic heterocyclic amines including Trp-P-1(3-amino-l,4-dimethyl-5H-pyrido❘4,3-b❘indole) and Trp-P-2(3-amino-1-methyl-5H-pyrido❘4,3-b❘indole) on human platelet aggregation and polymorphonuclear leukocyte aggregation. Only tryptophan pyrolysis products, Trp-P-1 and Trp-P-2, had potent inhibitory effects on human platelet aggregation when platelets were preincubated with the carcinogens for 15 min. Other carcinogenic heterocyclic amines such as glutamic acid pyrolysates (Glu-P-1 and Glu-P-2) and 3H-imidazo ❘4,5-f❘quinoline-2-amines(IQ and MelQ) did show no effect on platelet aggregation even at 100 μM.The autoradiogram demonstrated that Tryptophan pyrolysis products, Trp-P-1 and Trp-P-2, dose-dependently inhibited the formation of HHT,PGD2,PGE2 and TXB2 induced by sodium arachidonate in human platelets labeled with ❘ 14c❘ arachidonic acid. Moreover, Trp-P-1 and Trp-P-2 did not show significant effects on leukocyte aggregation induced by sodium arachidonate (0.75mM) even at lOOnM. It is concluded that Trp-P-1 and Trp-P-2 isolated from cooked foodstuffs have potent inhibitory effects on the cyclo-oxygenase pathway of the platelet. Therefore, human platelet function might be affected with daily foods containing tryptophan pyrolysis products in vivo.
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Indole Heterocyclic compounds' for particular source types:
Journal articles Dissertations / Theses
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography