Log in

Relevant bibliographies by topics / Indomethacin derivatives

Contents

Journal articles
Book chapters
Conference papers

Academic literature on the topic 'Indomethacin derivatives'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Indomethacin derivatives.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Indomethacin derivatives"

1

Deng, Kui Lin, Chun Xiu Li, Ting Gao, et al. "Preparation and Drug Release Behavior from a Temperature-Sensitive Poly(aspartic Acid) Derivatives Hydrogel." Advanced Materials Research 711 (June 2013): 18–21. http://dx.doi.org/10.4028/www.scientific.net/amr.711.18.

Full text

Abstract:

In this paper, a new pH/temperature-sensitive beads with semi-interpenetrating polymeric network based on sodium alginate(SA) and poly(aspartic acid) derivatives(M-E-PSI) were prepared using as drug delivery carrier. With indomethacin as a drug model，we investigated the release behaviors of indomethacin in different pH value, temperature and ratio of SA/ M-E-PSI. It turned out that the release amount of indomethacin in pH=2.1 phosphate buffer solution(PBS) was evidently higher than that in pH=7.4 PBS. And also, the release amount of indomethacin was also increased with increasing temperature a

APA, Harvard, Vancouver, ISO, and other styles

2

Abualhasan, Murad, Nidal Jaradat, Raghad Maslamani, Dana Nofal, and Linda Omar. "Synthesis of enhanced lipid solubility of indomethacin derivatives for topical formulations." Heterocyclic Communications 28, no. 1 (2022): 124–29. http://dx.doi.org/10.1515/hc-2022-0013.

Full text

Abstract:

Abstract Indomethacin is a nonselective nonsteroidal anti-inflammatory drug with serious side effects such as depression, hallucination, and gastrointestinal irritation. This study aims to enhance indomethacin lipid solubility of indomethacin derivative to use it for the topical formulation since topical formulation may lower the unwanted side effects. The lipid solubility was achieved by adding various alkyl groups (methyl, ethyl, propyl, and isopropyl) to the drug via an ester linkage. The measured log p of these compounds was higher compared to the underivatized indomethacin. Furthermore, a

APA, Harvard, Vancouver, ISO, and other styles

3

Lauro, Figueroa-Valverde, Díaz-Cedillo Francisco, García-Cervera Elodia, et al. "Activity Exerted by a Testosterone Derivative on Myocardial Injury Using an Ischemia/Reperfusion Model." BioMed Research International 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/217865.

Full text

Abstract:

Some reports indicate that several steroid derivatives have activity at cardiovascular level; nevertheless, there is scarce information about the activity exerted by the testosterone derivatives on cardiac injury caused by ischemia/reperfusion (I/R). Analyzing these data, in this study, a new testosterone derivative was synthetized with the objective of evaluating its effect on myocardial injury using an ischemia/reperfusion model. In addition, perfusion pressure and coronary resistance were evaluated in isolated rat hearts using the Langendorff technique. Additionally, molecular mechanism inv

APA, Harvard, Vancouver, ISO, and other styles

4

El-Gazzar, Abdel-Rahman, Hoda Hussein, and Hend Hafez. "Synthesis and biological evaluation of thieno[2,3-d]pyrimidine derivatives for anti-inflammatory, analgesic and ulcerogenic activity." Acta Pharmaceutica 57, no. 4 (2007): 395–411. http://dx.doi.org/10.2478/v10007-007-0032-6.

Full text

Abstract:

Synthesis and biological evaluation of thieno[2,3-d]pyrimidine derivatives for anti-inflammatory, analgesic and ulcerogenic activity5-Methyl-6-phenyl-2-thioxothieno[2,3-d]pyrimidone derivative (2) reacted with hydrazonoyl chloride derivatives to afford triazolothienopyrimidones4a-f.Also, acetone-1-(2-amino-5-isopropyl-thiophene-3-carbonitrile) (3) reacted with functional and bifunctional groups to yield the corresponding compounds5-11. The new products showed anti-inflammatory, analgesic, and ulcerogenic activities comparable to that of indomethacin and acetylsalicylic acid, respectively.

APA, Harvard, Vancouver, ISO, and other styles

5

Kuźmycz, Olga, Aleksandra Kowalczyk, and Paweł Stączek. "Biological Activity of fac-[Re(CO)3(phen)(aspirin)], fac-[Re(CO)3(phen)(indomethacin)] and Their Original Counterparts against Ishikawa and HEC-1A Endometrial Cancer Cells." International Journal of Molecular Sciences 23, no. 19 (2022): 11568. http://dx.doi.org/10.3390/ijms231911568.

Full text

Abstract:

Nonsteroidal anti-inflammatory drugs (NSAIDs) are inhibitors of cyclooxygenase enzyme (COX) and were found to have positive effects in reducing the risk of developing gynecological cancers. However, long-term administration of NSAIDs carries the risk of various side effects, including those in the digestive and circulatory systems. Therefore, there is a constant need to develop new NSAID derivatives. In this work, we investigated rhenium NSAIDs, comparing their effects on endometrial cancer cells with original NSAIDs, demonstrating the high activity of aspirin and indomethacin derivatives. The

APA, Harvard, Vancouver, ISO, and other styles

6

Serra Moreno, Judith, Dimitrios Agas, Maria Giovanna Sabbieti, Matteo Di Magno, Antonella Migliorini, and M. Antonietta Loreto. "Synthesis of novel pyrrolyl-indomethacin derivatives." European Journal of Medicinal Chemistry 57 (November 2012): 391–97. http://dx.doi.org/10.1016/j.ejmech.2012.09.008.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Mahdi, Monther Faisal, Ashour H. Dawood, and Ahmed Kareem Hussein. "Design, Synthesis and Preliminary Pharmacological Evaluation of Mutual Prodrug of Non-Steroidal Anti-Inflammatory Drugs Coupling With Natural Anti-Oxidants Via Glycine." Al Mustansiriyah Journal of Pharmaceutical Sciences 13, no. 1 (2013): 155–69. http://dx.doi.org/10.32947/ajps.v13i1.211.

Full text

Abstract:

Non-steroidal anti-inflammatory drugs (NSAIDs); naproxen and indomethacin have been conjugated with different antioxidants (thymol, menthol & guaiacol) having antiulcerogenic activity via glycine amino acid as spacer with the objective of obtaining NSAIDs-glycine- antioxidant prodrugs as gastrosparing NSAIDs devoid of ulcerogenic side effects and synergistically with anti-inflammatory action of glycine. Four mutual prodrugs (IIV) were synthesized using glycine as spacer and their structures were confirmed and characterized using elemental microanalysis (CHNO), IR, and some physiochemical p

APA, Harvard, Vancouver, ISO, and other styles

8

Benedek, G., P. Tóth-Daru, J. Janáky, A. Hortobágyi, F. Obál, and K. Colner-Sasi. "Indomethacin is Effective Against Neurogenic Hyperthermia Following Cranial Trauma or Brain Surgery." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 14, no. 2 (1987): 145–48. http://dx.doi.org/10.1017/s0317167100026275.

Full text

Abstract:

Abstract:The effectiveness of indomethacin treatment (1 mg/kg) as an antipyretic was tested in patients after cranial trauma or brain surgery involving the centromedial forebrain. Indomethacin was effective in reducing temperature in 10 of 11 cases which showed a dipyrone-resistant hyperthermia developing in the first 24 hours after brain damage, while no significant antipyretic effect was seen in hyperthermic cases developing more than 72 hours after cranial trauma or brain surgery. Biochemical tests estimating the effect of indomethacin, and pyrazolone derivatives on the arachidonic acid met

APA, Harvard, Vancouver, ISO, and other styles

9

El-Kashef, Hussein, Talaat El-Emary, Pierre Verhaeghe, Patrice Vanelle, and Maha Samy. "Anticancer and Anti-Inflammatory Activities of Some New Pyrazolo[3,4-b]pyrazines." Molecules 23, no. 10 (2018): 2657. http://dx.doi.org/10.3390/molecules23102657.

Full text

Abstract:

New derivatives of pyrazolo[3,4-b]pyrazines and related heterocycles were synthesized using 5-amino-3-methyl-4-nitroso-1-phenyl-pyrazole (1) as a starting material. The 5-acetyl derivative 15 was shown to be a useful key intermediate for the synthesis of several derivatives of pyrazolopyrazines. Some of the prepared compounds were evaluated for their anti-inflammatory and anti-breast cancer MCF-7 cell line activities. SAR study showed that compounds 15 and 29 exhibited remarkable anti-inflammatory activity, where 15 showed the same activity as that of the reference drug indomethacin. On the ot

APA, Harvard, Vancouver, ISO, and other styles

10

Haskologlu, Ismail Celil, Emine Erdag, Ahmet Ozer Sehirli, Orhan Uludag, and Nurettin Abacioglu. "Exploring the Therapeutic Potential of Benzoxazolone Derivatives on the Circadian Clock: An In Silico and Hypothetical Approach." Chronobiology in Medicine 6, no. 2 (2024): 87–99. http://dx.doi.org/10.33069/cim.2024.0012.

Full text

Abstract:

Objective: Pain conditions exhibit variations linked to circadian rhythms. Circadian rhythms, regulated by clock proteins, impact melatonin levels and immune functions. Melatonin, structurally similar to indomethacin, a non-steroidal anti-inflammatory drug, serves as an alternative in pain-related conditions. Literature suggests a correlation between melatonin-dependent regulation of circadian rhythm and reductions in pain complaints. 2(3<i>H</i>)-Benzoxazolone, known for its anti-inflammatory and analgesic properties, is a promising scaffold for drug design. In this study, pharmac

APA, Harvard, Vancouver, ISO, and other styles

More sources

Book chapters on the topic "Indomethacin derivatives"

1

KAHÁNNÉ-LÁSZLÓ, ILONA, I. LEPRÁN, M. KOLTAI, and L. SZEKERES. "EFFECT OF IS, A WATER SOLUBLE DERIVATIVE OF INDOMETHACIN, ON THE OUTCOME OF THE VERY EARLY PHASE OF EXPERIMENTAL MYOCARDIAL INFARCTION IN CONSCIOUS RATS." In Advances in Pharmacological Research and Practice. Elsevier, 1986. http://dx.doi.org/10.1016/b978-0-08-034190-3.50028-2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Indomethacin derivatives"

1

Zakai, Uzma I., Stephen Gately, and Robert West. "Abstract C50: Novel silicon derivatives of indomethacin: Generation of potent COX‐2 selective agents with improved anticancer activity." In Abstracts: First AACR International Conference on Frontiers in Basic Cancer Research--Oct 8–11, 2009; Boston MA. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.fbcr09-c50.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Zakai, Uzma I., Stephen Gately, and Robert West. "Abstract 668: Second generation silicon derivatives of indomethacin: Synthesis of potent COX-2 selective agents with improved anticancer activity." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-668.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!