Relevant bibliographies by topics / Indomethacin ethyl ester

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Indomethacin ethyl ester'

Author: Grafiati
Published: 4 June 2021
Last updated: 14 February 2022

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Journal articles on the topic "Indomethacin ethyl ester"

1

Cattani, Vitória B., Adriana R. Pohlmann, and Teresa Dalla Costa. "Pharmacokinetic evaluation of indomethacin ethyl ester-loaded nanoencapsules." International Journal of Pharmaceutics 363, no. 1-2 (2008): 214–16. http://dx.doi.org/10.1016/j.ijpharm.2008.07.008.

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2

Deng, Kui Lin, Qian Li, Xiao Hua Li, Yu Bo Gou, Li Rong Dong, and Chun Yuan Huang. "Drug Release Behaviors of a Novel Ph/Temperature Responsive Hydrogel with Jujube Cake-Like Structure." Advanced Materials Research 148-149 (October 2010): 994–97. http://dx.doi.org/10.4028/www.scientific.net/amr.148-149.994.

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A novel jujube cake-like pH/temperature responsive hydrogel, as a drug delivery system, was prepared by two steps in this paper. The intelligent copolymer hydrogel (PME) was obtained from N-acryloylglycinate methyl ester (AGME) and N-acryloylglycinate ethyl ester (AGEE), using sodium laurate (SL) as an emulsifier and N, N '-methylenebisacrylamide (NMBA) as a crosslinking agent. Selecting indomethacin as a model drug, in vitro drug release behaviors were investigated at different temperatures, phosphate buffer solutions (PBS) and emulsifier content. The cumulative release of indomethacin from t
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3

Cruz, Letícia, Scheila R. Schaffazick, Teresa Dalla Costa, et al. "Physico-Chemical Characterization and In Vivo Evaluation of Indomethacin Ethyl Ester-Loaded Nanocapsules by PCS, TEM, SAXS, Interfacial Alkaline Hydrolysis and Antiedematogenic Activity." Journal of Nanoscience and Nanotechnology 6, no. 9 (2006): 3154–62. http://dx.doi.org/10.1166/jnn.2006.417.

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Nanocapsules are vesicular drug carriers constituted of an oil core, a polymeric wall, and surfactants. A general understanding about the influence of the polymeric wall of nanocapsules on the release profiles of drugs is not known. So, this work was devoted to characterize formulations prepared without polymer or containing it at different concentrations. The indomethacin ethyl ester was used as model and the strategy was based on its interfacial alkaline hydrolysis simulating a sink condition for the release. The antiedematogenic activity in rats for ester-loaded-nanocarriers was also evalua
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4

Bernardi, Andressa, Rudimar L. Frozza, Eliézer Jäger, et al. "Selective cytotoxicity of indomethacin and indomethacin ethyl ester-loaded nanocapsules against glioma cell lines: An in vitro study." European Journal of Pharmacology 586, no. 1-3 (2008): 24–34. http://dx.doi.org/10.1016/j.ejphar.2008.02.026.

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5

Deng, Kui Lin, Li Rong Dong, Yu E. Shi, Yu Bo Gou, Qian Li, and Shu Liang Wang. "Drug Release Behaviors of a pH/Temperature Sensitive Hydrogel Bead with Core-Shelled Structure." Advanced Materials Research 148-149 (October 2010): 1427–30. http://dx.doi.org/10.4028/www.scientific.net/amr.148-149.1427.

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As a drug delivery carrier, a novel pH/temperature sensitive bead (pTSB) with core-shelled structure from poly(N-acryloylglycine) (PAG), copoly(N-acryloylglycine methyl este and N-acryloylglycine ethyl ester) was prepared by two steps. In pH=7.4 phosphate buffer solution (PBS), the cumulative release amount of indomethacin loaded in the pTSB was about 60.1 % within 500 mins, but this value only reached to 22.3 % in pH=2.1 PBS. The release behaviors of indomethacin from pTSB also exhibited a remarkable dependence on PAG content in the core. Additionally, the release rate of indomethacin was muc
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6

Pohlmann, Adriana R., Leticia Cruz, Graziela Mezzalira, Leonardo U. Soares, Nadya P. Da Silveira, and Silvia S. Guterres. "Structural model of polymeric nanospheres containing indomethacin ethyl ester and in vivo antiedematogenic activity." International Journal of Nanotechnology 4, no. 5 (2007): 454. http://dx.doi.org/10.1504/ijnt.2007.014744.

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7

Cheung, P. Y., and R. Schulz. "Glutathione causes coronary vasodilation via a nitric oxide- and soluble guanylate cyclase-dependent mechanism." American Journal of Physiology-Heart and Circulatory Physiology 273, no. 3 (1997): H1231—H1238. http://dx.doi.org/10.1152/ajpheart.1997.273.3.h1231.

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The actions of thiols on coronary vascular tone in the intact heart are unknown. Glutathione (GSH), glutathione disulfide (GSSG), and L-cysteine (10-1,000 microM each) and GSH ethyl ester (3-300 microM) were infused into isolated rat hearts perfused with Krebs buffer at a constant pressure by the Langendorff method. GSH, GSSG, and GSH ethyl ester, but not L-cysteine, caused a concentration-dependent increase in coronary flow with the following order of potency: GSH ethyl ester > GSH = GSSG. The nitric oxide synthase inhibitor NG-monomethyl-L-arginine (300 microM), prevented the increase in
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8

Simeoni, Umberto, Thierry Massfelder, Christian Saussine, Clément Judes, Jean Geisert, and Jean-Jacques Helwig. "Involvement of Nitric Oxide in the Vasodilatory Response to Parathyroid Hormone-Related Peptide in the Isolated Rabbit Kidney." Clinical Science 86, no. 3 (1994): 245–49. http://dx.doi.org/10.1042/cs0860245.

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1. The present study was designed to explore the role of NO derived from l-arginine in the vasodilatory response to synthetic human parathyroid hormone-related peptide-(1–34) in the isolated rabbit kidney perfused in the presence of indomethacin (10 μmol/l) and preconstricted with noradrenaline (7.2 nmol/min). 2. Under control conditions, bolus administrations of acetylcholine (10 μmol/l), an NO-dependent renal vasodilator, verapamil (0.1 mmol/l), an NO-independent renal vasodilator, and parathyroid hormone-related peptide (87 nmol/l) decreased the preconstriction pressure, by 31%, 71% and 43%
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9

Dai, Rong, Ting Wang, Xiaoqin Si, et al. "Vasodilatory effects and underlying mechanisms of the ethyl acetate extracts from Gastrodia elata." Canadian Journal of Physiology and Pharmacology 95, no. 5 (2017): 564–71. http://dx.doi.org/10.1139/cjpp-2016-0407.

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The objective of this study was to assess the ethyl acetate extracts of Gastrodia elata Blume (GEB) on vascular tone and the mechanisms involved. GEB was extracted with 95% EtOH followed by a further extraction with ethyl acetate. The effects of GEB and its ingredients on the isometric tensions of the aortic rings from rats were measured. The ethyl acetate extract of GEB induced a vasodilatory effect on rat aorta, which was partially dependent on endothelium. Four chemical compounds isolated from GEB were identified as 3,4-dihydroxybenzaldehyde (DB), 4-hydroxybenzaldehyde (HB), 4-methoxybenzyl
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10

Cattani, Vitória Berg, Luana Almeida Fiel, Alessandro Jäger, et al. "Lipid-core nanocapsules restrained the indomethacin ethyl ester hydrolysis in the gastrointestinal lumen and wall acting as mucoadhesive reservoirs." European Journal of Pharmaceutical Sciences 39, no. 1-3 (2010): 116–24. http://dx.doi.org/10.1016/j.ejps.2009.11.004.

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Dissertations / Theses on the topic "Indomethacin ethyl ester"

1

Cattani, Vitória Berg. "Avaliação farmacocinética do éster etílico de indometacina nanoencapsulado e da indometacina formada in vivo." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2007. http://hdl.handle.net/10183/10874.

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Objetivos: Avaliar a farmacocinética do éster etílico de indometacina (IndOEt) em ratos Wistar, após sua administração oral (p.o) e intravenosa (i.v.) nas formas livre ou nanoencapsulada, e monitorar a formação de indometacina (IndOH) in vivo. Metodologia: Os protocolos experimentais foram aprovados pelo Comitê de Ética em Pesquisa da UFRGS (2005478). Nanocápsulas (NC) contendo IndOEt (IndOEt- NC) foram administradas p.o. (10 mg/kg) e i.v. bolus (5 mg/kg) a ratos machos Wistar (n = 5 a 7/grupo) e as concentrações plasmáticas de IndOEt e IndOH resultantes foram determinadas por CLAE com detecçã
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2

Jager, Eliézer. "Controle da liberação do éster etílico de indometacina a partir de nanocápsulas poliméricas através da variação da concentração do monoestearato de sorbitano." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/13723.

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O trabalho tem como objetivo determinar a influencia da concentração de monoestearato de sorbitano, componente do núcleo oleoso das nanocápsulas, na cinética de liberação do éster etílico de indometacina a partir de nanocápsulas de poli(ε-caprolactona) (PCL). Com este propósito o éster etílico de indometacina foi associado a cada sistema e sua hidrólise alcalina foi realizada para simular uma condição sink. A velocidade de consumo do éster etílico de indometacina foi menor conforme o aumento da concentração do monoestearato de sorbitano. O tempo de meia-vida do consumo do éster etílico de indo
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