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Journal articles on the topic 'Induction-dynamic transducer'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Rodionova, Elena Yurievna. "A comparative characterization of recording devices for vibration signals on the example of <i>Heterocerus fenestratus</i> (Thunberg, 1784) (Coleoptera: Heteroceridae)." Samara Journal of Science 12, no. 1 (2023): 111–16. http://dx.doi.org/10.55355/snv2023121117.

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Works on vibration communication for Orthoptera and Hemiptera are widely known in Russian literature. Basically, the piezoelectric adapter GZK-661 or the electromagnetic transducer GZM-105 are used for recording this communication. The use of these devices does not give satisfactory results when recording insects smaller than 1 cm. In this paper we consider a comparative characteristic of recording devices based on the piezoelectric transducer GZK-661, electromagnetic transducer GZM-105 and electrodynamic head eas15s02m when recording vibration communication of near-water rigid-winged Heteroce

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Kolganov, O. A., A. E. Khoshev, R. A. Egorov, A. V. Fedorov, G. N. Lukyanov, and V. V. Konyashov. "Development of a sensor layout for a dynamic indentation device." Дефектоскопия, no. 9 (September 15, 2023): 64–66. http://dx.doi.org/10.31857/s0130308223090099.

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Issues related to the design of a dynamic indentation sensor are presented in this paper. The use of a magnetic induction method for recording the motion parameters of a striker with a differential circuit of inductors is proposed. A prototype of the primary transducer and a sensor model with a new mechanism for the striker reset system are developed.

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Amirov, Sulton Fayzullayevich, and Asror Abdunabiyevich Shoimkulov. "STUDY OF DYNAMIC CHARACTERISTICS OF THE MECHANICAL CIRCUIT OF THE DEVELOPED INDUCTION INERTIAL VIBRATION TRANSDUCER." Chemical Technology, Control and Management 2023, no. 6 (2023): 23–32. http://dx.doi.org/10.59048/2181-1105.1534.

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4

Yang, Liang En, Xuan Ze Wang, and Lin Zheng. "Displacement Sensor with Controlled Measuring Force and its Characteristics Analysis." Applied Mechanics and Materials 103 (September 2011): 309–13. http://dx.doi.org/10.4028/www.scientific.net/amm.103.309.

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A displacement sensor with controlled measuring force and its characteristics analysis are discussed in this paper. The displacement sensor consists of an electric induction transducer with high resolution and a voice coil motor (VCM). The measuring principles, structure of the sensor are discussed. Theory model, dynamic and static characteristics of VCM are analysed. A measuring system for surface topography with large measuring range is constructed based on the displacement sensor and 2D moving platform. Measuring force of the sensor in measurement process of surface topography can be contro

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5

Murayama, Riichi. "Examination of Pole Structure for Static Magnetic Field Constituting Electromagnetic Acoustic Transducer (EMAT) for Lamb Wave Using Electromagnetic Induction Coil with Ferromagnetic Core." Advances in Image and Video Processing 13, no. 01 (2025): 453–64. https://doi.org/10.14738/aivp.1301.18366.

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To increase the mechanical and thermal strengths of the EMAT for Lamb waves, the air-core electromagnetic induction coil that constitutes the EMAT was changed to a structure in which a conductor is wound around a ferromagnetic material. Initially, the coils for the static and dynamic magnetic fields were vertically wound around low-carbon steel, a ferromagnetic material. As a result, a transmission signal was detected. To further improve the received signal strength, a structure separating the poles for the static and dynamic magnetic fields was evaluated. It was then confirmed that an improve

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6

DEVADASON, JOATHAN, PAUL S. MOSES, and MOHAMMAD A. S. MASOUM. "Multiparameter Stability Analysis of Systems with Induction Motor Loads, Weak Interconnections and Series Compensation." WSEAS TRANSACTIONS ON CIRCUITS AND SYSTEMS 20 (June 28, 2021): 128–38. http://dx.doi.org/10.37394/23201.2021.20.16.

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Dynamic modeling and stability domain analysis of a system consisting of a synchronous generator sup-plying an induction motor load through a series compensated weak network has been carried out in this paper. The impact of X/Rratio of the feeder and generation control system parameters on the stability domain with respect to series compensation has been examined through eigenvalue calculations and time domain simulations. From the studies conducted, it was observed that the stability domain of the system with respect to series compensation depends on the grid strength in addition to the excit

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Tsuchiya, Katsumi, and Xiaolu Wang. "Ultrasonic Atomization—From Onset of Protruding Free Surface to Emanating Beads Fountain—Leading to Mist Spreading." Fluids 10, no. 4 (2025): 89. https://doi.org/10.3390/fluids10040089.

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The process of ultrasonic atomization involves a series of dynamic/topological deformations of free surface, though not always, of a bulk liquid (initially) below the air. This study focuses on such dynamic interfacial alterations realized by changing some acousto-related operating conditions, including ultrasound excitation frequency, acoustic strength or input power density, and the presence/absence of a “stabilizing” nozzle. High-speed, high-resolution imaging made it possible to qualitatively identify four representative transitions/demarcations: (1) the onset of a protrusion on otherwise

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8

Guediri, Mourad, Slimane Touil, Messaoud Hettiri, et al. "Control of a Doubly Fed Induction Generator for Variable Speed Wind Energy Conversion Systems using Fuzzy Controllers optimized with a Genetic Algorithm." Engineering, Technology & Applied Science Research 15, no. 1 (2025): 19871–77. https://doi.org/10.48084/etasr.9460.

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This paper presents a comprehensive study of a wind turbine system operating under variable wind conditions, utilizing a Doubly Fed Induction Generator (DFIG) connected to the grid. The DFIG is controlled via a rotor-side transducer, allowing for independent regulation of the conductors to manage both active and reactive power flows effectively. The control strategy focuses on generating reference voltages for the rotor to ensure that active and reactive power align with the desired targets, optimizing the tracking of the maximum power point to maximize electrical output. The research analyzes

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Guediri, A., A. Guediri, and S. Touil. "Modeling and Comparison of Fuzzy-PI and Genetic Control Algorithms for Active and Reactive Power Flow between the Stator (DFIG) and the Grid." Engineering, Technology & Applied Science Research 12, no. 3 (2022): 8640–45. http://dx.doi.org/10.48084/etasr.4905.

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This paper performs a comparison between Fuzzy-PI regulators and Genetic Algorithm (GA) for controlling an active and reactive Doubly-Fed Induction Generator (DFIG) for providing power to the electrical grid. Theoretical analysis, modeling, and simulation studies are provided. Control strategies were developed for both active and reactive forces in order to optimize energy production. The performance of the two control strategies was examined and compared using benchmarks for durability and reference traceability. This paper studied a system consisting of a wind turbine operating at variable w

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Alberti, Saverio, Emanuela Guerra, Antonino Moschella, et al. "Abstract 346: Trop-2 induces apoptosis via transcriptional activation of TRAIL, FAS-FASL, CD40-TNFRSF5." Cancer Research 84, no. 6_Supplement (2024): 346. http://dx.doi.org/10.1158/1538-7445.am2024-346.

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Abstract Trop-2 is a transmembrane signal transducer that activates cancer growth and metastatic diffusion (1). However, this does not occur in all tumor types, as Trop-2 is associated to better disease outcome in some cancers, e.g. breast and lung tumors. A prototypic pattern of Trop-2 expression in normal multistratified epithelia, e.g. epidermis, esophagus, is that of preferential expression in non-proliferating, terminally differentiated cells. The corresponding expression gradient parallels that of induction of programmed cell death, e.g. in the corneum layer of skin keratinocytes. This l

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Alberti, Saverio, Valeria Relli, Romina Tripaldi, et al. "Abstract 2550: Growth factor-induced cell membrane macroplatforms drive protein kinase signaling for transformed cell growth." Cancer Research 83, no. 7_Supplement (2023): 2550. http://dx.doi.org/10.1158/1538-7445.am2023-2550.

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Abstract Nanoscopic, millisecond-lasting membrane platforms are modeled to constitute main functional signaling units. However, multiple signaling events in cell growth induction, including receptor Tyr-kinase (RTK) stimulation, calcium signaling, cytoplasmic kinase recruitment, operate over much broader space-time frames. Through dynamic confocal/super-resolution/electron-microscopy on living cells, we discovered that signaling competence is acquired through growth factor-induced coalescence of activated growth inducers (RTK, CD9, CD81, CD98, Co-029, CD316, Trop-1, Trop-2, PI3K, PI4K), and do

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Liu, Xuan, Carolina Ciumas, Yu-Min Huang, et al. "Autoantigen-pulsed dendritic cells constitute a beneficial cytokine and growth factor network in ameliorating experimental allergic encephalomyelitis." Multiple Sclerosis Journal 11, no. 4 (2005): 381–89. http://dx.doi.org/10.1191/1352458505ms1180oa.

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Injection of myelin basic protein (MBP)-pulsed dendritic cells (DC) into healthy rats, as we reported before and observed in this study, did not induce clinical experimental allergic encephalomyelitis (EAE), but effectively protected the rats from subsequent EAE induction. The mechanisms by which MBP-pulsed DC mediate immune protection are not completely understood. In the present study, we mainly explored the dynamic change of cytokine and growth factor mRNA expression in spinal cords after subcutaneous injection of MBP-pulsed and unpulsed DC. The expression of interleukin (IL)-1, interferon-

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13

Bobkov, Yurii. "Classification and analysis of measuring transducers of intensity (induction) of alternating magnetic fields." MECHANICS OF GYROSCOPIC SYSTEMS, no. 40 (December 26, 2021): 82–93. http://dx.doi.org/10.20535/0203-3771402020249113.

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The current state of technology is characterized by the mass use of electricity, the use of various electrical, electronic and radio devices. This causes expansion of magnetic measurements and the need to develop new highly sensitive measuring equipment for a wide range of frequencies. One of its main elements, that largely determines the accuracy, frequency and dynamic ranges, are the primary measuring sensors of strength (induction) of alternating magnetic fields. Many works have been devoted to the analysis and development of various sensors of strength (induction) of magnetic fields.

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14

Boikhanov, Z. U. "DYNAMIC CHARACTERISTICS OF CONTROLLED OUTPUT VOLTAGE CONVERTERS." Journal of Science and Innovative Development 5, no. 2 (2022): 133–39. http://dx.doi.org/10.36522/2181-9637-2022-2-14.

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This article uses a controlled output voltage-to-current converter to control the reactive power of an induction motor. The dynamic characteristics of the current converter were obtained using the Simulink program, taking into account reliability, sensitivity, measurement accuracy and error. Current converters are mainly operated during normal stable operation of the power supply system of an asynchronous motor. In this mode, when studying current transducers with certain conditional limits, the minimum and maximum values of the input current are accepted, for which the accuracy class (0.1‒1.2

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15

Liu, Xiangyang, Sanjan T. P. Gupta, Devesh Bhimsaria, et al. "De novo design of programmable inducible promoters." Nucleic Acids Research 47, no. 19 (2019): 10452–63. http://dx.doi.org/10.1093/nar/gkz772.

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Abstract Ligand-responsive allosteric transcription factors (aTF) play a vital role in genetic circuits and high-throughput screening because they transduce biochemical signals into gene expression changes. Programmable control of gene expression from aTF-regulated promoter is important because different downstream effector genes function optimally at different expression levels. However, tuning gene expression of native promoters is difficult due to complex layers of homeostatic regulation encoded within them. We engineered synthetic promoters de novo by embedding operator sites with varying

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16

Guediri, Abdelkarim, Messaoud Hettiri, and Abdelhafid Guediri. "Modeling of a Wind Power System Using the Genetic Algorithm Based on a Doubly Fed Induction Generator for the Supply of Power to the Electrical Grid." Processes 11, no. 3 (2023): 952. http://dx.doi.org/10.3390/pr11030952.

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This paper is interested in studying a system consisting of a wind turbine operating at variable wind speeds, and a two-feed asynchronous machine (DFIG) connected to the grid by a stator and fed by a transducer at the side of the rotor. The conductors are separately controlled for active and reactive power flow between the stator (DFIG) and the grid. The proposed controllers generate reference voltages for the rotor to ensure that the active and reactive power reaches the required reference values, to ensure effective tracking of the optimum operating point and to obtain the maximum electrical

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17

Kramer, Anne Marijn, Mengyong Yan, Karl S. Peggs, John Anderson та Kenth Gustafsson. "Tumor-Associated Antigen Presentation by γδ T-Cells in Cancer Immunotherapy". Blood 124, № 21 (2014): 1411. http://dx.doi.org/10.1182/blood.v124.21.1411.1411.

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Abstract Tumor-Associated Antigen Presentation by γδ T-Cells in Cancer Immunotherapy Human γδ T-cells are considered to represent a link between innate and adaptive immunity. Their innate killing properties display a potent cytotoxic activity against solid tumors as well as lymphoid and myeloid malignancies. Subsequently, by lysing affected target cells and liberating antigen for uptake, they can differentiate into professional antigen presenting cells (pAPCs) for induction of CD4+ and CD8+ T cell responses. The degree of antigen-specific stimulation of responder T cells is increased in the pr

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18

Dunussi-Joannopoulos, Kyriaki, Kathlene Runyon, Jamie Erickson, Robert G. Schaub, Robert G. Hawley, and John P. Leonard. "Vaccines With Interleukin-12–Transduced Acute Myeloid Leukemia Cells Elicit Very Potent Therapeutic and Long-Lasting Protective Immunity." Blood 94, no. 12 (1999): 4263–73. http://dx.doi.org/10.1182/blood.v94.12.4263.

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Abstract Interleukin-12 (IL-12) is a heterodimeric cytokine mediating a dynamic interplay between T cells and antigen-presenting cells (APCs). Preclinical studies have demonstrated that recombinant murine IL-12 (rmIL-12) promotes specific antitumor immunity mediated by T cells in several types of tumors. However, the in vivo antitumor properties of IL-12 in acute myeloid leukemia (AML) have not been previously reported. We show here in a murine AML model that systemic administration of rmIL-12 significantly delays tumor growth but is incapable of rescuing mice from lethal leukemia. In contrast

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19

Dunussi-Joannopoulos, Kyriaki, Kathlene Runyon, Jamie Erickson, Robert G. Schaub, Robert G. Hawley, and John P. Leonard. "Vaccines With Interleukin-12–Transduced Acute Myeloid Leukemia Cells Elicit Very Potent Therapeutic and Long-Lasting Protective Immunity." Blood 94, no. 12 (1999): 4263–73. http://dx.doi.org/10.1182/blood.v94.12.4263.424k30_4263_4273.

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Interleukin-12 (IL-12) is a heterodimeric cytokine mediating a dynamic interplay between T cells and antigen-presenting cells (APCs). Preclinical studies have demonstrated that recombinant murine IL-12 (rmIL-12) promotes specific antitumor immunity mediated by T cells in several types of tumors. However, the in vivo antitumor properties of IL-12 in acute myeloid leukemia (AML) have not been previously reported. We show here in a murine AML model that systemic administration of rmIL-12 significantly delays tumor growth but is incapable of rescuing mice from lethal leukemia. In contrast, AML cel

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20

Salari, Azam, Kathrin Thomay, Andrea Schienke, et al. "Dynamic Telomere Shortening and Chromosomal Instability in Irradiated CD34+ Cells Transduced with TP53 Hotspot Mutations R175H, R248W and R249S." Blood 126, no. 23 (2015): 4832. http://dx.doi.org/10.1182/blood.v126.23.4832.4832.

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Abstract Patients with MDS and a complex karyotype have a very short median survival and a high risk of transformation into AML. We showed earlier that TP53 mutations are associated with complex karyotype and disease progression. However, it is poorly understood how TP53 mutations contribute to the induction of chromosomal instability in hematopoietic stem and progenitor cells. We therefore established a long-term cell culture (LTC) model and investigated the role of TP53 in human CD34+ hematopoietic stem and progenitor cells (HSCs) isolated from cord blood and in HT1080 cells over 6 weeks. We

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21

Taylor, Cormac T. "Mitochondria and cellular oxygen sensing in the HIF pathway." Biochemical Journal 409, no. 1 (2007): 19–26. http://dx.doi.org/10.1042/bj20071249.

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Mitochondrial respiration is responsible for more than 90% of oxygen consumption in humans. Cells utilize oxygen as the final electron acceptor in the aerobic metabolism of glucose to generate ATP which fuels most active cellular processes. Consequently, a drop in tissue oxygen levels to the point where oxygen demand exceeds supply (termed hypoxia) leads rapidly to metabolic crisis and represents a severe threat to ongoing physiological function and ultimately, viability. Because of the central role of oxygen in metabolism, it is perhaps not surprising that we have evolved an efficient and rap

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22

Reiss, Kim, Yuan Yuan, Debora Barton, et al. "951 A phase 1 first in human study of adenovirally transduced anti-HER2 CAR macrophages in subjects with HER2 overexpressing solid tumors: preliminary safety, pharmacokinetics, and TME reprogramming data." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A1000. http://dx.doi.org/10.1136/jitc-2021-sitc2021.951.

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BackgroundCT-0508 is an autologous monocyte-derived pro-inflammatory macrophage cell product engineered with Ad5f35 to express an anti-HER2 CAR. In pre-clinical studies CT-0508 was safe and effective. This abstract contains preliminary results from the first-in-human experience with CAR macrophages (CAR-M).MethodsThis First-In-Human Phase 1, multi-center, open-label study is evaluating the safety, tolerability, manufacturing feasibility, pharmacokinetics and mechanism of action of CT-0508 in 18 subjects with advanced solid tumors overexpressing HER2 who have progressed on prior therapies, incl

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23

Sive, Jonathan I., Fernando J. Calero-Nieto, Rebecca Hannah, and Berthold Göttgens. "Genome-Scale Analysis of the Pu.1 Driven Transcriptional Programme That Overcomes the Differentiation Block in a Novel Pu.1-Inducible AML Cell Line." Blood 124, no. 21 (2014): 869. http://dx.doi.org/10.1182/blood.v124.21.869.869.

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Abstract Transcription factors (TFs) play a key role in determining normal haematopoiesis; haematological cancers often being characterised by TF dysregulation. Pu.1 is a TF that plays a major role in myeloid differentiation, with mutations and down regulation of Pu.1 activity described in human acute myeloid leukemia (AML). To investigate the role of Pu.1 in normal and leukemic myeloid fate, we developed a model of inducible Pu.1 rescue in a murine AML cell line, and utilised it to assess genome-wide Pu.1-DNA-binding profiles and the subsequent effects on histone remodelling, gene expression

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Huang, Huilin, Hengyou Weng, Xi Qin, et al. "The N6-Adenine Methyltransferase METTL14 Plays an Oncogenic Role in Acute Myeloid Leukemia." Blood 128, no. 22 (2016): 1536. http://dx.doi.org/10.1182/blood.v128.22.1536.1536.

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Abstract N 6-methyladenosine (m6A) modification is the most abundant internal RNA modification in eukaryotes. Recent studies have shown that the dynamic and reversible regulation of m6A modifications in mRNAs or non-coding RNAs plays critical roles in tissue development, stem cell self-renewal and differentiation, control of heat shock response, and circadian clock controlling, as well as in RNA metabolism and processing. However, little is known about the functions of m6A and m6A regulators in malignant hematopoiesis. METTL14 is a major m6A writer which together with METTL3 forms the core of

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Stokes, Nicole, David Dominguez-Sola, and Eirini P. Papapetrou. "Functional Analysis of MYC Deregulation By Diverse Genetic Mechanisms during Hematopoiesis." Blood 132, Supplement 1 (2018): 1323. http://dx.doi.org/10.1182/blood-2018-99-110829.

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Abstract Alterations of the c-MYC (MYC) locus, mainly in the form of translocations or amplifications, are common in hematologic malignancies and result in deregulated MYC expression, disrupting cellular proliferation and differentiation and promoting leukemogenesis. While amplified MYC loci typically maintain all native cis-regulatory elements, translocated loci are instead driven by heterologous regulatory regions and are therefore expected to be unresponsive to external signals. However, no studies have directly compared the effects of different modes of MYC deregulation in cellular phenoty

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Glez-Vaz, Javier, Arantza Azpilikueta, Irene Olivera, et al. "Abstract 628: Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies." Cancer Research 82, no. 12_Supplement (2022): 628. http://dx.doi.org/10.1158/1538-7445.am2022-628.

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Abstract Background: On the basis of efficacy in mouse tumor models, multiple CD137 (4-1BB) agonist agents are being preclinically and clinically developed. The costimulatory molecule CD137 is inducibly expressed as a transmembrane or as a soluble protein (sCD137). Moreover, the CD137 cytoplasmic signaling domain is a key part in approved Chimeric Antigen Receptors (CARs). Reliable pharmacodynamic biomarkers for CD137 ligation and co-stimulation of T cells will facilitate clinical development of CD137 agonists in the clinic. Methods: We used human and mouse CD8 T cells undergoing activation to

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Yoshihara, Hiroki, Michelle L. Churchman, Jennifer L. Peters, et al. "Functional and Genomic Characterization of the Interaction between Acute Lymphoblastic Leukemia Cells and the Microenvironment Identifies Pathways for Therapeutic Intervention." Blood 132, Supplement 1 (2018): 1550. http://dx.doi.org/10.1182/blood-2018-99-117894.

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Abstract Introduction Residence and interaction with a specialized bone marrow microenvironment is important for normal hematopoietic stem cells and for initiation and progression of myeloid malignancies, but the role of the microenvironment in propagation and therapeutic response of acute lymphoblastic leukemia (ALL) is not well known. Prior work has identified the efficacy of inhibiting FAK signaling, which is deregulated by IKZF1 alterations resulting in induction of THY1-Integrin alpha 5 adhesion in Ph-positive (Ph+) ALL. Here, we hypothesized that this mechanism may be more broadly import

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28

Dörr, Jan, Selina Keppler, Maja Milanovic, et al. "Therapy-Inducible Senescence Activates Both Innate and Adaptive Immune Mechanisms That Control Lymphoma Growth In Vivo." Blood 118, no. 21 (2011): 107. http://dx.doi.org/10.1182/blood.v118.21.107.107.

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Abstract Abstract 107 Introduction: Premature senescence is a cellular failsafe mechanism which is induced upon various cellular insults, such as oncogene activation or exposure to DNA damaging chemotherapy. It suppresses tumor formation and acts as a barrier to tumor progression in vivo. In contrast to apoptotic cells, senescent cells are viably arrested in the G1 phase of the cell cycle. They continue to take up nutrients and interact with tumor and host cells. To what extent senescent cells alter the tumor environment and tumor-host interactions remains largely unsolved. Here, we analyze ly

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Dörr, Jan, Maja Milanovic, Christoph Loddenkemper, et al. "Role of Senescence in Dynamic Tumor/Host Responses to Cancer Therapy In Vivo." Blood 114, no. 22 (2009): 928. http://dx.doi.org/10.1182/blood.v114.22.928.928.

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Abstract Abstract 928 Introduction: Premature senescence is a terminal G1 growth arrest in response to acute cellular stresses, such as oncogene activation or exposure to DNA damaging chemotherapy, with tumor-suppressive activity in vivo. However, senescent cells remain viable. They are metabolically active and have a distinct senescence-associated secretory profile (SASP). Therefore, the function and the fate of senescent cells within the tumor site, particularly their impact on the tumor microenvironment, are highly complex and not well characterized. Here, we analyze lymphoma cells with def

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Gaines, Peter, Deepali Gotur, Stephanie Halene, Ada L. Olins, and Donald E. Olins. "Dynamic Expression of the Lamin B Receptor and Associated Proteins during Myeloid Differentiation: Insight into Mechanisms of Neutrophil Vs. Macrophage Morphogenesis." Blood 112, no. 11 (2008): 3546. http://dx.doi.org/10.1182/blood.v112.11.3546.3546.

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Abstract Neutrophils and macrophages are professional phagocytes that are essential to the immune response and that have developmental and functional similarities. They derive from a common myeloid progenitor and require common transcription factors for their differentiation, such as PU.1 and the CCAAT/enhancer binding proteins C/EBPα and C/EBPε. However, the morphologic maturation of these two lineages is distinct; neutrophil progenitors undergo a progressive series of nuclear changes that culminate in the formation of lobulated nuclei, whereas macrophage progenitors first form circulating mo

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Rodrigues Lopes, Matheus, João Agostinho Machado-Neto, Fabiola Traina, et al. "FMNL1 Is Downregulated In Myelodysplastic Syndromes and Is Involved In Megakaryocytic Differentiation." Blood 122, no. 21 (2013): 1519. http://dx.doi.org/10.1182/blood.v122.21.1519.1519.

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Abstract Background Myelodysplastic syndromes (MDS) are disorders characterized by morphological dysplasia, impaired differentiation and defective cellular functions, resulting in peripheral cytopenias. FMNL1 belongs to a family of formin-related proteins, indispensable for many fundamental actin-dependent processes. Recently, FMNL1 has been described to be upregulated and play a role in the actin cytoskeleton dynamics during monocyte differentiation to macrophages. Aims The aim of this work was to characterize FMNL1 expression in total bone marrow cells of patients with MDS comparing to norma

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Sun, Ruifeng, Jaewoong Lee, Mark E. Robinson, et al. "Mechanism of Negative Feedback Regulation of Oncogenic BCR-Signaling in Mature B-Cell Lymphoma." Blood 144, Supplement 1 (2024): 3003. https://doi.org/10.1182/blood-2024-211693.

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Background and Significance: CD25 (IL2RA) has been extensively studied as IL2-receptor chains expressed on T- and NK-cells. However, CD25 is sharply upregulated upon BCR-signaling. Mature B-cell lymphoma subtypes (CLL, MCL, DLBCL) that depend on oncogenic BCR-signaling inactivate CD25 by proteolytic cleavage and aggressiveness of disease is associated with low expression CD25 surface levels and high serum levels of cleaved CD25. Results: Here, we discovered a mechanistic framework of dynamic BCR-feedback control and its dependency on coordinated activity of PKCδ and CD25. To study the role of

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Gregory, Georgia L., Beeke Wienert, Marisa Schwab, et al. "Investigating Zeta Globin Gene Expression to Develop a Potential Therapy for Alpha Thalassemia Major." Blood 136, Supplement 1 (2020): 3–4. http://dx.doi.org/10.1182/blood-2020-142922.

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Introduction: Alpha globin mutations are very common worldwide, and the severity of resulting anemia depends on the number and type of mutated alleles. While the 4 gene mutation (alpha thalassemia major, ATM) was previously deemed fatal except in rare cases, emerging evidence indicates that survival to birth and good postnatal outcomes are possible with in utero transfusions. We hypothesized that the embryonic zeta globin gene, which is expressed early in gestation prior to alpha globin, may compensate for the lack of alpha globin and that induction of zeta globin after it has naturally been s

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Noce, Valeria, Cecilia Battistelli, Angela Maria Cozzolino та ін. "YAP integrates the regulatory Snail/HNF4α circuitry controlling epithelial/hepatocyte differentiation". Cell Death & Disease 10, № 10 (2019). http://dx.doi.org/10.1038/s41419-019-2000-8.

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Abstract Yes-associated protein (YAP) is a transcriptional co-factor involved in many cell processes, including development, proliferation, stemness, differentiation, and tumorigenesis. It has been described as a sensor of mechanical and biochemical stimuli that enables cells to integrate environmental signals. Although in the liver the correlation between extracellular matrix elasticity (greatly increased in the most of chronic hepatic diseases), differentiation/functional state of parenchymal cells and subcellular localization/activation of YAP has been previously reported, its role as regul

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Suehiro, Jun-ichi, Mai Miura, Tatsuhiko Kodama, and Takashi Minami. "Abstract 1301: NFATc- And SRF-induced Early Growth Response (Egr)-3 Is Essential For VEGF-mediated Endothelial Cell Migration And Tube Formation." Circulation 116, suppl_16 (2007). http://dx.doi.org/10.1161/circ.116.suppl_16.ii_266.

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Endothelium is a dynamic cell layer constantly responding to changes in the various extracellular mediators. Responses are usually beneficial to host, but oversustained or dysregulated responses can result in vascular dysfunction, leading to the initiation of atherosclerosis, tumor growth, and inflammation. Such endothelial cell activation and dysfunction are mediated in large part by alterations in gene expression. Here we show, using comprehensive transcriptome analyses, that VEGF, thrombin and TNF-α each induces a dramatic and rapid up-regulation of early growth response (Egr)-3 in human um

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Wawrzyniak, Piotr, and Mariusz L. Hartman. "Dual role of interferon-gamma in the response of melanoma patients to immunotherapy with immune checkpoint inhibitors." Molecular Cancer 24, no. 1 (2025). https://doi.org/10.1186/s12943-025-02294-x.

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Abstract Interferon-gamma (IFN-γ) is a cytokine produced mainly by immune cells and can affect cancer cells by modulating the activity of multiple signaling pathways, including the canonical Janus-activated kinase/signal transducer and activator of transcription (JAK/STAT) cascade. In melanoma, IFN-γ can exert both anticancer effects associated with cell-cycle arrest and cell death induction and protumorigenic activity related to immune evasion leading to melanoma progression. Notably, IFN-γ plays a crucial role in the response of melanoma patients to immunotherapy with immune checkpoint inhib

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Xiong, Xuekai, Weini Li, Ruya Liu, Pradip Saha, Vijay Yechoor, and Ke Ma. "Circadian clock control of MRTF/SRF pathway suppresses beige adipocyte thermogenic recruitment." Journal of Molecular Cell Biology, December 29, 2022. http://dx.doi.org/10.1093/jmcb/mjac079.

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Abstract The morphological transformation of adipogenic progenitors into mature adipocytes requires dissolution of actin cytoskeleton with loss of myocardin-related transcription factor (MRTF)/serum response factor (SRF) activity. Circadian clock confers temporal control in adipogenic differentiation, while the actin cytoskeleton–MRTF/SRF signaling transduces extracellular physical niche cues. Here, we define a novel circadian transcriptional control involved in actin cytoskeleton–MRTF/SRF signaling cascade that modulates beige fat thermogenic function. Key components of actin dynamic–MRTF/SRF

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Zerzeri, Mouna, Intissar Moussa, and Adel Khedher. "Wind turbine emulator using three-phase IM controlled through an adaptive reactive power estimator fed by soft-VSI topology." COMPEL - The international journal for computation and mathematics in electrical and electronic engineering, March 6, 2024. http://dx.doi.org/10.1108/compel-10-2023-0529.

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Purpose The purpose of this paper aims to design a robust wind turbine emulator (WTE) based on a three-phase induction motor (3PIM). Design/methodology/approach The 3PIM is driven by a soft voltage source inverter (VSI) controlled by a specific space vector modulation. By adjusting the appropriate vector sequence selection, the desired VSI output voltage allows a real wind turbine speed emulation in the laboratory, taking into account the wind profile, static and dynamic behaviors and parametric variations for theoretical and then experimental analysis. A Mexican hat profile and a sinusoidal p

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Proulx, Jessica M., In-Woo Park, and Kathleen Borgmann. "HIV-1 and methamphetamine co-treatment in primary human astrocytes: TAARgeting ER/UPR dysfunction." NeuroImmune Pharmacology and Therapeutics, February 19, 2024. http://dx.doi.org/10.1515/nipt-2023-0020.

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Abstract Objectives Human immunodeficiency virus 1 (HIV-1) can invade the central nervous system (CNS) early during infection and persist in the CNS for life despite effective antiretroviral treatment. Infection and activation of residential glial cells lead to low viral replication and chronic inflammation, which damage neurons contributing to a spectrum of HIV-associated neurocognitive disorders (HAND). Substance use, including methamphetamine (METH), can increase one’s risk and severity of HAND. Here, we investigate HIV-1/METH co-treatment in a key neurosupportive glial cell, astrocytes. Sp

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Hershey, David M., Aretha Fiebig, and Sean Crosson. "Flagellar Perturbations Activate Adhesion through Two Distinct Pathways in Caulobacter crescentus." mBio 12, no. 1 (2021). http://dx.doi.org/10.1128/mbio.03266-20.

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ABSTRACT Bacteria carry out sophisticated developmental programs to colonize exogenous surfaces. The rotary flagellum, a dynamic machine that drives motility, is a key regulator of surface colonization. The specific signals recognized by flagella and the pathways by which those signals are transduced to coordinate adhesion remain subjects of debate. Mutations that disrupt flagellar assembly in the dimorphic bacterium Caulobacter crescentus stimulate the production of a polysaccharide adhesin called the holdfast. Using a genomewide phenotyping approach, we compared surface adhesion profiles in

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