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Journal articles on the topic 'Infarcts'

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1

Han, Moon-Ku, Dong-Wha Kang, Byung-Woo Yoon, and Jae-Kyu Roh. "Vascular Territorial Classification and Etiologies of Acute MCA Infarct by Diffusion-Weighted MRI." Stroke 32, suppl_1 (2001): 346. http://dx.doi.org/10.1161/str.32.suppl_1.346-d.

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P42 Background and Purpose - The purpose of this study is to classify infarct subtypes of middle cerebral artery distribution (MCA) seen on diffusion-weighted MRI (DWI) and investigate infarct mechanisms and etiologies of MCA infarct subtypes. Method - We analysed 187 consecutive patients with acute MCA infarct who were studied by DWI/MRA within the first 4 days of stroke onset between 1997 and 1999, and stroke mechanism was determinedaccording to the criteria of the Trial of Org 10172 in Acute Stroke Treatment (TOAST). Infarct patterns from 128 patients except for lacunar infarcts (patients)
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Kumar, Abhay, Robert Brown, Rajat Dhar, et al. "Early vs Delayed Cerebral Infarction After Aneurysm Repair After Subarachnoid Hemorrhage." Neurosurgery 73, no. 4 (2013): 617–23. http://dx.doi.org/10.1227/neu.0000000000000057.

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Abstract BACKGROUND: Cerebral infarction is a major contributor to poor outcome after subarachnoid hemorrhage (SAH). Although usually considered a complication of delayed cerebral ischemia, infarcts may also occur early, in relation to initial brain injury or aneurysm-securing procedures. OBJECTIVE: We analyzed the relative frequency and volume of early vs delayed infarcts after SAH and their relationship to hospital outcome. METHODS: Retrospective review of consecutive patients admitted with aneurysmal SAH over 4 years who had follow-up brain imaging 7 days or later after admission. Imaging 2
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3

Skriver, E. B., and T. S. Olsen. "Repeated Computed Tomography in Lacunar Infarcts of the Brain." Acta Radiologica 30, no. 1 (1989): 1–6. http://dx.doi.org/10.1177/028418518903000101.

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This prospective and consecutive study of 74 patients with completed stroke elucidates occurrence, localization and evolution of lacunar infarcts on repeated CT examinations. Twenty patients had large infarcts (diameter >3 cm), 25 medium-sized infarcts (diameter ≥1.5 cm – ≤ 3 cm), and 16 had lacunar infarcts (diameter <1.5 cm). In 13 patients no infarct was seen. The lacunar infarcts were characterized by delayed appearance on CT, low incidence of fog effect, and infrequent presence of contrast enhancement. In 9 of the 16 patients (56%) the lacunar infarct could be identified on the firs
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Żmigrodzki, Jakub, Szymon Cygan, and Krzysztof Kałużyński. "Parametrization of subsegmental infarcts using high spatial resolution 2DSTE and synthetic ultrasonic data." Polish Journal of Medical Physics and Engineering 29, no. 4 (2023): 195–207. http://dx.doi.org/10.2478/pjmpe-2023-0021.

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Abstract Introduction: The purpose of this study was to assess the performance of a set of parameters in characterizing simulated infarcts in left ventricular (LV) models with variations in size and transmural extent. Material and methods: The deformation of the LV models with different infarct sizes was simulated using the Finite Element Method. These simulations provided meshes that were used to generate synthetic ultrasonic data within the FIELD II package. The strain components (longitudinal and circumferential) were then estimated over small subsegments of the of segments 7 and 12 (accord
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5

Pfeffer, J. M., M. A. Pfeffer, P. J. Fletcher, and E. Braunwald. "Progressive ventricular remodeling in rat with myocardial infarction." American Journal of Physiology-Heart and Circulatory Physiology 260, no. 5 (1991): H1406—H1414. http://dx.doi.org/10.1152/ajpheart.1991.260.5.h1406.

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Ventricular dilatation may have important prognostic implications for the survival of patients with left ventricular (LV) dysfunction. To determine the manner and extent to which the left ventricle of the rat remodels and dilates after myocardial infarction, we obtained the passive pressure-volume relationships, chamber stiffness constants, and mass during both the early and late phases. In moderate and large infarcts as inflammation and edema developed, LV weight increased then progressively decreased as a thin scar formed, returning to normal values as a result of compensatory hypertrophy of
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6

Nudo, R. J., and G. W. Milliken. "Reorganization of movement representations in primary motor cortex following focal ischemic infarcts in adult squirrel monkeys." Journal of Neurophysiology 75, no. 5 (1996): 2144–49. http://dx.doi.org/10.1152/jn.1996.75.5.2144.

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1. Intracortical microstimulation (ICMS) techniques were used to derive detailed maps of distal forelimb movement representations in primary motor cortex (area 4) of adult squirrel monkeys before and a few months after a focal ischemic infarct. 2. Infarcts caused a marked but transient deficit in use of the contralateral hand, as evidenced by increased use of the ipsilateral hand, and reduced performance on a task requiring skilled digit use. 3. Infarcts resulted in a widespread reduction in the areal extent of digit representations adjacent to the lesion, and apparent increases in adjacent pr
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7

Fomovsky, Gregory M., and Jeffrey W. Holmes. "Evolution of scar structure, mechanics, and ventricular function after myocardial infarction in the rat." American Journal of Physiology-Heart and Circulatory Physiology 298, no. 1 (2010): H221—H228. http://dx.doi.org/10.1152/ajpheart.00495.2009.

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The mechanical properties of the healing scar are an important determinant of heart function following myocardial infarction. Yet the relationship between scar structure, scar mechanics, and ventricular function remains poorly understood, in part because no published study has tracked all of these factors simultaneously in any animal model. We therefore studied the temporal evolution of scar structure, scar mechanics, and left ventricular (LV) function in large anterior myocardial infarcts in rats. At 1, 2, 3, and 6 wk after left anterior descending coronary ligation, we examined LV function u
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8

Mishra, Ajay Kumar, Vanjare Harshad Arvind, Divya Muliyil, et al. "Cerebrovascular injury in cryptococcal meningitis." International Journal of Stroke 13, no. 1 (2017): 57–65. http://dx.doi.org/10.1177/1747493017706240.

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Background Cryptococcal meningitis continues to be one of the common causes of chronic central nervous system infection worldwide. Individuals with cryptococcal meningitis can occasionally present with small vessel vasculitis causing infarcts primarily in the basal ganglia, internal capsule, and thalamus. Literature regarding patterns of cerebrovascular injury among patients with cryptococcal meningitis is scanty, and outcome following these vascular involvements is unknown. Aim To study the clinical profile, imaging findings, and details of vascular territory involved among patients admitted
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9

Filipović Danić, S., V. Mitrović, and N. Petrović. "NEURORADIOLOGICAL (CT) COMPLICATION IMPLICATORS OF BRAIN SUPRATENTORIAL INFARCTS AND THEIR SIGNIFICANCE IN PREDICTING THE OUTCOME." Praxis medica 38, no. 1 (2010): 71–75. http://dx.doi.org/10.70949/pramed201001329f.

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<p>One of leading causes of death in the world is stroke, more often it strikes population under the age of 65, and those who survive it are left with a maximum degree of invalidity. Supratentorial infarcts are the most common form of ACM, occuring as a consequence of blood vessel occlusion, which irrigation zone is above tentorium, and it appears in 80% of infarcts. Diagnosing of such infarcts is based on clinical and neuroradiological parameters, and computed tomografy is called "gold standard". Therefor, our goal was to introduce a CT parameters, which follow
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10

Cimen, Erol, Kelvin Ng, Brian H. Buck, et al. "Importance of infarct topography in determination of stroke mechanism and recurrence risk: a post-hoc analysis of the dabigatran acute treatment of stroke trial." BMJ Open 15, no. 1 (2025): e087704. https://doi.org/10.1136/bmjopen-2024-087704.

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ObjectiveTo evaluate the relationship between infarct pattern, inferred stroke mechanism and risk of recurrence in patients with ischaemic stroke. The question is clinically relevant to optimise secondary stroke prevention investigations and treatment.DesignWe conducted a retrospective analysis of the dabigatran treatment of acute stroke II (DATAS II) trial (ClinicalTrials.gove NCTNCT02295826), in which patients underwent diffusion-weighted imaging (DWI) at baseline and 30 days after randomisation to one of two antithrombotic therapies. Patients were classified as embolic, isolated small subco
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Ospel, Johanna M., Petra Cimflova, Martha Marko, et al. "Prevalence and Outcomes of Medium Vessel Occlusions With Discrepant Infarct Patterns." Stroke 51, no. 9 (2020): 2817–24. http://dx.doi.org/10.1161/strokeaha.120.030041.

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Background and Purpose: The prognosis of medium vessel occlusions (MeVOs), that is, M2/3 middle cerebral artery, A2/3 anterior cerebral artery, and P2/3 posterior cerebral artery occlusions, is generally better compared with large vessel occlusions, since brain ischemia is less extensive. However, in some MeVO patients, infarcts are seen outside the territory of the occluded vessel (MeVO with discrepant infarcts). This study aims to determine the prevalence and clinical impact of discrepant infarct patterns in acute ischemic stroke due to MeVO. Methods: We pooled data of MeVO patients from INT
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Tharaldsen, Ane R., Kathinka D. Kurz, Martin W. Kurz, et al. "Volume and Visual Field Defects in Occipital Stroke: The NOR-OCCIP Study." Acta Neurologica Scandinavica 2023 (August 24, 2023): 1–6. http://dx.doi.org/10.1155/2023/3564863.

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Introduction. The majority of patients with occipital infarcts display homonymous visual field defects (VFD), with negative implications on activities of daily living and quality of life. To overcome the disability, better prognostic markers in the acute phase, as well as more targeted rehabilitation, would be useful. The aim of the current study was to present an overview of the topographic distribution of occipital infarcts and to investigate whether lesion volume can predict VFD at baseline and after six months. Materials and Methods. Multicenter, prospective study including patients with a
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13

Cauley, Keith A., Gino J. Mongelluzzo, and Samuel W. Fielden. "Automated Estimation of Acute Infarct Volume from Noncontrast Head CT Using Image Intensity Inhomogeneity Correction." International Journal of Biomedical Imaging 2019 (August 21, 2019): 1–8. http://dx.doi.org/10.1155/2019/1720270.

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Identification of early ischemic changes (EIC) on noncontrast head CT scans performed within the first few hours of stroke onset may have important implications for subsequent treatment, though early stroke is poorly delimited on these studies. Lack of sharp lesion boundary delineation in early infarcts precludes manual volume measures, as well as measures using edge-detection or region-filling algorithms. We wished to test a hypothesis that image intensity inhomogeneity correction may provide a sensitive method for identifying the subtle regional hypodensity which is characteristic of early i
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Ganesh, A., JM Ospel, AT Wilson, M. Goyal, M. Tymianski, and MD Hill. "P.083 Early and 30-day clinical and neuropsychological effects of iatrogenic brain infarcts in the ENACT randomized-controlled trial." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 48, s3 (2021): S43. http://dx.doi.org/10.1017/cjn.2021.362.

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Background: Small brain infarcts are often seen on diffusion-weighted MRI(DWI) following surgical/endovascular procedures. Little is known about their clinical effects. We examined the association of iatrogenic infarcts with outcomes in the ENACT(Evaluating Neuroprotection in Aneurysm Coiling Therapy) trial of nerinetide in endovascular aneurysm repair. Methods: In this post-hoc analysis, we used multi-variable models to evaluate the association of presence/number of DWI iatrogenic infarcts with NIHSS(National Institutes of Health Stroke Scale), mRS(modified Rankin Scale), and cognitive/neurop
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15

Garcia-Dorado, D., P. Theroux, M. Desco, et al. "Cell-to-cell interaction: a mechanism to explain wave-front progression of myocardial necrosis." American Journal of Physiology-Heart and Circulatory Physiology 256, no. 5 (1989): H1266—H1273. http://dx.doi.org/10.1152/ajpheart.1989.256.5.h1266.

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Histological sections performed 24 h after coronary occlusion in eight pigs displayed compact infarcts extending transmurally with well-defined edges; reconstruction and inspection of the area of necrosis showed a geometric distribution of the infarcts with very irregular, interdigitating edges always in continuity with the main mass of necrosis. Reperfusion in 32 pigs after periods of coronary occlusion of 90, 60, 45, and 30 min exponentially reduced infarct size and transmural extension of the infarct but did not modify its geometry. The two-dimensional size, progression, and geometry of the
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16

Yaghi, Shadi, Traci M. Bartz, Richard Kronmal, et al. "Left atrial diameter and vascular brain injury on MRI." Neurology 91, no. 13 (2018): e1237-e1244. http://dx.doi.org/10.1212/wnl.0000000000006228.

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ObjectiveTo determine the association left atrial diameter (LAD) and vascular brain injury on brain MRI.MethodsWe analyzed data from the Cardiovascular Health Study (CHS), a prospective cohort of community-dwelling adults ≥65 years old. LAD was measured from 2-dimensional transthoracic echocardiograms. Among CHS participants who underwent brain MRI, we examined associations of LAD with brain infarcts and leukoaraiosis. Primary outcomes (number for analysis) were prevalent infarcts (2,327) and degree of leukoaraiosis on initial MRI (2,315). Secondary outcomes were prevalent nonlacunar infarcts
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Fandler, Simon, Thomas Gattringer, Daniela Pinter, et al. "Dysphagia in supratentorial recent small subcortical infarcts results from bilateral pyramidal tract damage." International Journal of Stroke 13, no. 8 (2018): 815–19. http://dx.doi.org/10.1177/1747493018778141.

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Background Dysphagia occurs in up to 20% of patients with a recent small subcortical infarct, even when excluding brainstem infarcts. Aim To examine the impact of lesion topography and concomitant cerebrovascular lesions on the occurrence of dysphagia in patients with a single supratentorial recent small subcortical infarct. Methods We retrospectively identified all inpatients with magnetic resonance imaging-confirmed supratentorial recent small subcortical infarcts over a five-year period. Dysphagia was determined by speech-language therapists. Recent small subcortical infarcts were compiled
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18

Garg, Anil, and Deepak Agrawal. "Acute arterial infarcts in patients with severe head injuries." Indian Journal of Neurosurgery 01, no. 02 (2012): 126–29. http://dx.doi.org/10.4103/2277-9167.102276.

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Abstract To study the incidence, demographic profile, and outcome of patients with severe closed head injuries who develop acute arterial infarcts. Patients with severe head injury (Glasgow coma score (GCS) ≤8) presenting within 8 h of injury in the Department of Neurosurgery over a period of 5 months were enrolled in the study. Patients with penetrating head injury, infarct due to herniation and iatrogenic arterial injuries were excluded from the study. Only arterial infarcts developing within 8 h of injury were included in the study. A computed tomography (CT) head was done on all patients w
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Casolla, Barbara, Gregory Kuchcinski, Maéva Kyheng, et al. "Infarct Volume Before Hemicraniectomy in Large Middle Cerebral Artery Infarcts Poorly Predicts Catastrophic Outcome." Stroke 51, no. 8 (2020): 2404–10. http://dx.doi.org/10.1161/strokeaha.120.029920.

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Background and Purpose: Infarct volumes predict malignant infarcts in patients undergoing decompressive hemicraniectomy (DH) for large middle cerebral artery territory infarcts. The aim of the study was to determine the optimal magnetic resonance imaging infarct volume threshold that predicts a catastrophic outcome at 1 year (modified Rankin Scale score of 5 or death). Methods: We included consecutive patients who underwent DH for large middle cerebral artery infarcts. We analyzed infarct volumes before DH with semi-automated methods on b1000 diffusion-weighted imaging sequences and apparent d
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Brown, Robert J., Abhay Kumar, Rajat Dhar, Tomoko R. Sampson, and Michael N. Diringer. "The Relationship Between Delayed Infarcts and Angiographic Vasospasm After Aneurysmal Subarachnoid Hemorrhage." Neurosurgery 72, no. 5 (2013): 702–8. http://dx.doi.org/10.1227/neu.0b013e318285c3db.

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Abstract BACKGROUND: Delayed cerebral ischemia is common after aneurysmal subarachnoid hemorrhage (aSAH) and is a major contributor to poor outcome. Yet, although generally attributed to arterial vasospasm, neurological deterioration may also occur in the absence of vasospasm. OBJECTIVE: To determine the relationship between delayed infarction and angiographic vasospasm and compare the characteristics of infarcts related to vasospasm vs those unrelated. METHODS: A retrospective review of patients with aSAH admitted from July 2007 through June 2011. Patients were included if they were admitted
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Sigurdsson, Sigurdur, Thor Aspelund, Olafur Kjartansson, et al. "Cerebrovascular Risk-Factors of Prevalent and Incident Brain Infarcts in the General Population: The AGES-Reykjavik Study." Stroke 53, no. 4 (2022): 1199–206. http://dx.doi.org/10.1161/strokeaha.121.034130.

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Background: Studies on the association of cerebrovascular risk factors to magnetic resonance imaging detected brain infarcts have been inconsistent, partly reflecting limits of assessment to infarcts anywhere in the brain, as opposed to specific brain regions. We hypothesized that risk-factors may differ depending on where the infarct is located in subcortical-, cortical-, and cerebellar regions. Methods: Participants (n=2662, mean age 74.6±4.8) from the longitudinal population-based AGES (Age, Gene/Environment Susceptibility)-Reykjavik Study underwent brain magnetic resonance imaging at basel
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Rao, Vaishnavi L., Michael Mlynash, Søren Christensen, et al. "Collateral status contributes to differences between observed and predicted 24-h infarct volumes in DEFUSE 3." Journal of Cerebral Blood Flow & Metabolism 40, no. 10 (2020): 1966–74. http://dx.doi.org/10.1177/0271678x20918816.

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We previously demonstrated that in the DEFUSE 3 trial, the union of the baseline core and the 24-h Tmax > 6 s perfusion lesion predicts the infarct volume at 24 h. Presently, we assessed if collateral robustness measured by the hypoperfusion intensity ratio (HIR) and cerebral blood volume (CBV) index accounts for the variance in these predictions. DEFUSE 3 patients underwent MRI/CT perfusion imaging at baseline and 24 h post-randomization. We compared baseline and follow-up HIR and CBV index across subgroups stratified by differences between predicted and observed 24-h infarct volumes. Of 1
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Lin, Chen, Rajbeer Sangha, Jungwha Lee, et al. "Infarct location is associated with quality of life after mild ischemic stroke." International Journal of Stroke 13, no. 8 (2018): 824–31. http://dx.doi.org/10.1177/1747493018783760.

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Background In patients with mild ischemic stroke, small but eloquent infarcts may have devastating effects, particularly on health-related quality of life. Aim This study investigates the association between acute infarct location and three-month health-related quality of life in patients with mild ischemic stroke. Methods We evaluated consecutively enrolled patients from a single center between August 2012 and July 2013. Our primary outcome at three months was impairment in any health-related quality of life domain (upper extremity, lower extremity, executive function, and general concerns) d
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Rozen, TD. "Vanishing Cerebellar Infarcts in a Migraine Patient." Cephalalgia 27, no. 6 (2007): 557–60. http://dx.doi.org/10.1111/j.1468-2982.2007.01317.x.

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Recent population-based studies have suggested that migraine is a risk factor for the development of infarct-like lesions in the territory of the posterior circulation. These lesions are thought to be true vascular infarcts based on their size, location and magnetic resonance imaging (MRI) characteristics. However, as there are no postmortem studies identifying the pathology of these MRI findings, their true aetiology is unknown. A case patient with migraine is presented, who developed what appeared to be cerebellar infarcts on MRI, but these lesions vanished on repeat imaging 16 days later, q
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de Blank, Peter M. K., Daniel M. Hayward, Robert Zimmerman, MD, Avrum Pollock, and Janet L. Kwiatkowski. "Transcranial Doppler Ultrasound Velocity, Cerebral Vasculopathy, and Silent Infarcts In Sickle Cell Disease." Blood 116, no. 21 (2010): 269. http://dx.doi.org/10.1182/blood.v116.21.269.269.

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Abstract Abstract 269 Background: Approximately one-fourth of children with sickle cell disease (SCD), type SS, show evidence of cerebral ischemia on magnetic resonance imaging (MRI) without overt neurologic symptoms. Children with these silent infarcts have an increased risk of neuropsychological abnormalities and overt stroke. The pathophysiology of silent infarcts is unclear. Elevated transcranial Doppler ultrasound (TCD) velocities in the internal cerebral artery (ICA) and middle cerebral artery (MCA) are associated with an increased risk of overt stroke, but have not been associated previ
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Kusumoto, Keiji, James V. Haist, and Morris Karmazyn. "Na+/H+ exchange inhibition reduces hypertrophy and heart failure after myocardial infarction in rats." American Journal of Physiology-Heart and Circulatory Physiology 280, no. 2 (2001): H738—H745. http://dx.doi.org/10.1152/ajpheart.2001.280.2.h738.

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We investigated the effect of sodium/hydrogen exchange inhibition (NHE-1) on hypertrophy and heart failure after coronary artery ligation (CAL) in the rat. Animals were subjected to occlusion (or sham) of the left main coronary artery and immediately administered a control diet or one consisting of the NHE-1 inhibitor cariporide for 13–15 wk. Hearts were separated by small [≤30% of left ventricle (LV)] and large (>30% of LV) infarcts. CAL depressed change in left ventricular increase in pressure over time (LV +dP/d t) in small and large infarct groups by 18.8% ( P < 0.05) and 34% ( P &lt
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Toriello, A., N. D. Pugliese, F. Izzi, A. Siani, G. Locatelli, and R. Saponiero. "Neuroradiological and Neuropsychological Study of a Callosal Infarct." Neuroradiology Journal 21, no. 6 (2008): 830–34. http://dx.doi.org/10.1177/197140090802100613.

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Corpus callosum infarcts are rare, constituing 0.6% of cerebral infarcts, most likely due to a rich blood supply from three main arterial systems. These infarcts may present with slowly evolving and non-localizing neurologic signs and symptoms that suggest the diagnosis of neoplasm rather than infarct. In addition, they may exhibit radiologic features more often associated with neoplasm, such as mass-like enhancement or extension across the midline. We describe a patient with corpus callosum infarct presenting with a non specific ataxia-like gait disorder, speech difficulty and left-side weakn
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Soepriatna, Arvin H., A. Kevin Yeh, Abigail D. Clifford, Semih E. Bezci, Grace D. O'Connell, and Craig J. Goergen. "Three-dimensional myocardial strain correlates with murine left ventricular remodelling severity post-infarction." Journal of The Royal Society Interface 16, no. 160 (2019): 20190570. http://dx.doi.org/10.1098/rsif.2019.0570.

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Heart failure continues to be a common and deadly sequela of myocardial infarction (MI). Despite strong evidence suggesting the importance of myocardial mechanics in cardiac remodelling, many MI studies still rely on two-dimensional analyses to estimate global left ventricular (LV) function. Here, we integrated four-dimensional ultrasound with three-dimensional strain mapping to longitudinally characterize LV mechanics within and around infarcts in order to study the post-MI remodelling process. To induce infarcts with varying severities, we separated 15 mice into three equal-sized groups: (i)
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Azeemuddin, Muhammad, Muhammad Awais, Fatima Mubarak, Abdul Rehman, and Noor Ul-Ain Baloch. "Prevalence of subarachnoid haemorrhage among patients with cranial venous sinus thrombosis in the presence and absence of venous infarcts." Neuroradiology Journal 31, no. 5 (2018): 496–503. http://dx.doi.org/10.1177/1971400918783060.

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Introduction In patients with cranial venous sinus thrombosis, the occurrence of subarachnoid haemorrhage in association with haemorrhagic venous infarcts is a well described phenomenon. However, the presence of subarachnoid haemorrhage in patients with cranial venous sinus thrombosis in the absence of a haemorrhagic venous infarct is exceedingly rare. Methods We retrospectively reviewed charts and scans of all patients who had cranial venous sinus thrombosis confirmed by magnetic resonance venography at our hospital between September 2004 and May 2015. The presence of subarachnoid haemorrhage
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Mendez, R. E., J. M. Pfeffer, F. V. Ortola, et al. "Atrial natriuretic peptide transcription, storage, and release in rats with myocardial infarction." American Journal of Physiology-Heart and Circulatory Physiology 253, no. 6 (1987): H1449—H1455. http://dx.doi.org/10.1152/ajpheart.1987.253.6.h1449.

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To study the role of atrial natriuretic peptide (ANP) in chronic heart failure, ANP synthesis, storage, and release were examined by measuring atrial ANP messenger ribonucleic acid (mRNA) levels and atrial and plasma ANP concentrations in rats with myocardial infarction produced by coronary artery ligation. Three groups were defined as the following: 1) controls, sham-operated, or operated, but noninfarcted; 2) moderate infarcts, involving 5-30% of the left ventricular circumference; and 3) large infarcts (greater than or equal to 30%). In addition, to determine a possible modulation by dietar
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West, G. Alexander, Kiarash J. Golshani, Kristian P. Doyle, et al. "A New Model of Cortical Stroke in the Rhesus Macaque." Journal of Cerebral Blood Flow & Metabolism 29, no. 6 (2009): 1175–86. http://dx.doi.org/10.1038/jcbfm.2009.43.

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Primate models are essential tools for translational research in stroke but are reportedly inconsistent in their ability to produce cortical infarcts of reproducible size. Here, we report a new stroke model using a transorbital, reversible, two-vessel occlusion approach in male rhesus macaques that produces consistent and reproducible cortical infarcts. The right middle cerebral artery (distal to the orbitofrontal branch) and both anterior cerebral arteries were occluded with vascular clips. Bilateral occlusion of the anterior cerebral artery was critical for reducing collateral flow to the ip
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Conforto, Adriana Bastos, Fábio Iuji Yamamoto, Cláudia da Costa Leite, Milberto Scaff, and Suely Kazue Nagahashi Marie. "Facial sensory symptoms in medullary infarcts." Arquivos de Neuro-Psiquiatria 63, no. 4 (2005): 947–50. http://dx.doi.org/10.1590/s0004-282x2005000600008.

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OBJECTIVE: To investigate the correlation between facial sensory abnormalities and lesional topography in eight patients with lateral medullary infarcts (LMIs). METHOD: We reviewed eight sequential cases of LMIs admitted to the Neurology Division of Hospital das Clínicas/ São Paulo University between July, 2001 and August, 2002 except for one patient who had admitted in 1996 and was still followed in 2002. All patients were submitted to conventional brain MRI including axial T1-, T2-weighted and Fluid attenuated inversion-recovery (FLAIR) sequences. MRIs were evaluated blindly to clinical feat
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Tokunaga, Keisuke, Go Hashimoto, Tadataka Mizoguchi, et al. "Left Atrial Appendage Flow Velocity and Multiple Infarcts in Cryptogenic Stroke." Cerebrovascular Diseases 50, no. 4 (2021): 429–34. http://dx.doi.org/10.1159/000514672.

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<b><i>Background:</i></b> To validate the hypothesis that cryptogenic stroke with multiple infarcts included embolic stroke due to left atrial appendage (LAA) dysfunction, the present retrospective observational study was aimed to clarify the association between LAA flow velocity (LAA-FV) and multiple infarcts in patients with cryptogenic stroke. <b><i>Methods:</i></b> From consecutive patients with cryptogenic stroke admitted to our hospital within 7 days after onset, patients without brain magnetic resonance imaging (MRI) on admission or withou
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van den Bos, Ewout J., Barend M. E. Mees, Monique C. de Waard, Rini de Crom, and Dirk J. Duncker. "A novel model of cryoinjury-induced myocardial infarction in the mouse: a comparison with coronary artery ligation." American Journal of Physiology-Heart and Circulatory Physiology 289, no. 3 (2005): H1291—H1300. http://dx.doi.org/10.1152/ajpheart.00111.2005.

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Mouse myocardial infarction (MI) models are frequently used research tools. The most commonly applied model is coronary artery ligation. However, coronary ligation often gives rise to apical aneurysmatic infarcts of variable size. Other infarct models include cryoinfarction, which produces reproducible infarcts of the anterior wall. Thus far, this model has not been extensively described in mice. Therefore, we developed a murine cryoinfarction model and compared it with coronary ligation. Studies were performed under isoflurane anesthesia with a follow-up of 4 and 8 wk. Cryoinfarction was indu
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35

TANG, W. K., YANGKUN CHEN, WYNNIE W. M. LAM, et al. "Emotional incontinence and executive function in ischemic stroke: A case-controlled study." Journal of the International Neuropsychological Society 15, no. 1 (2009): 62–68. http://dx.doi.org/10.1017/s1355617708090061.

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AbstractFrontal and basal ganglia infarcts and executive dysfunction are thought to be involved in the pathophysiology of poststroke emotional incontinence (PSEI). The study examined whether patients with PSEI have more frontal and/or basal ganglia infarcts and impairment in executive function. A total of 516 Chinese patients with acute ischemic stroke consecutively admitted to the acute stroke unit of a university-affiliated regional hospital in Hong Kong were screened for PSEI 3 months after the index stroke. According to Kim’s criteria, 39 (7.6%) had PSEI. Thirty-nine stroke patients withou
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36

Carlsson, M., P. C. Ursell, D. Saloner, and M. Saeed. "Multidetector computed tomography for characterization of calcium deposits in reperfused myocardial infarction." Acta Radiologica 50, no. 4 (2009): 396–405. http://dx.doi.org/10.1080/02841850902756540.

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Background: Calcium overload is a major cause of reperfusion myocardial injury. Multidetector computed tomography (MDCT) has been previously used in visualizing coronary artery calcium, but not calcium deposits in reperfused infarction. Purpose: To assess the ability of MDCT to 1) noninvasively visualize and characterize calcium deposits in reperfused infarcts, and 2) monitor regional wall swelling, regional systolic wall thickening, and infarct resorption. Material and Methods: Reperfused myocardial infarcts were created in seven pigs by 2-hour occlusion of the left anterior descending corona
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37

Filipović, S., V. Mitrović, N. Petrović, and D. Ljuši. "CLINICAL MANIFESTATION OF SUPRATENTORIAL BRANE INFARCT COMPARED TO INFARCT ZONE LOCALIZATION." Praxis medica 39, no. 1 (2011): 69–73. http://dx.doi.org/10.70949/pramed201101401f.

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<p>Epidemiological characteristics of acute stroke certify the great importance of such disease, which takes the measures of a mass incontagious illness, because it represents one of leading causes of death and invalidity in the world. Contemporary knowledge about the complexity of cerebral infarct has been significantly increased thanks to new imaging methods, which allows correction of clinicaly stated diagnose. The aim of our research was to determine clinical manifestation signs of supratentorial infarcts and their presence compared to anatomic localisations of lesions. 60 pa
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38

Ganesh, Aravind, Mayank Goyal, Alexis T. Wilson, et al. "Association of Iatrogenic Infarcts With Clinical and Cognitive Outcomes in the Evaluating Neuroprotection in Aneurysm Coiling Therapy Trial." Neurology 98, no. 14 (2022): e1446-e1458. http://dx.doi.org/10.1212/wnl.0000000000200111.

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Background and ObjectivesSmall iatrogenic brain infarcts are often seen on diffusion-weighted MRI (DWI) following surgical or endovascular procedures, but there are few data on their clinical effects. We examined the association of iatrogenic infarcts with outcomes in the ENACT (Evaluating Neuroprotection in Aneurysm Coiling Therapy) randomized controlled trial of nerinetide in patients undergoing endovascular repair of intracranial aneurysms.MethodsIn this post hoc analysis, we used multivariable models to evaluate the association of the presence and number of iatrogenic infarcts on DWI with
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39

Connelly, C. M., J. A. Leppo, P. W. Weitzman, W. M. Vogel, and C. S. Apstein. "Effect of coronary occlusion and reperfusion on myocardial blood flow during infarct healing." American Journal of Physiology-Heart and Circulatory Physiology 257, no. 2 (1989): H365—H374. http://dx.doi.org/10.1152/ajpheart.1989.257.2.h365.

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Coronary occlusion (CO) of 1 h or longer causes transmural myocardial infarction (MI) in the rabbit. We studied how reperfusion of an infarct affected myocardial blood flow (MBF) acutely and after 3 wk of healing. CO was performed in rabbits for 60 or 180 min (n = 22) followed by reperfusion, and MBF to normal and infarcted zones was determined by radioactive microspheres. In a separate series (n = 23), MBF was measured at 21-25 days post-CO in three groups that had either permanent CO or reperfusion after 60 or 180 min of CO. MBF to the infarct was approximately 8 +/- 3% (+/-SE) of normal MBF
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40

Prabhakaran, Shyam, David S. Liebeskind, George Cotsonis, et al. "Predictors of Early Infarct Recurrence in Patients With Symptomatic Intracranial Atherosclerotic Disease." Stroke 52, no. 6 (2021): 1961–66. http://dx.doi.org/10.1161/strokeaha.120.032676.

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Background and Purpose: While prior studies identified risk factors for recurrent stroke in patients with symptomatic intracranial atherosclerotic disease, few have assessed risk factors for early infarct recurrence. Methods: We performed a post hoc analysis of the MYRIAD study (Mechanisms of Early Recurrence in Intracranial Atherosclerotic Disease) of intracranial atherosclerotic disease patients with recent (<21 days) stroke/transient ischemic attack, 50% to 99% stenosis and who underwent 6- to 8-week magnetic resonance imaging (MRI) per protocol. Infarct recurrence was defined as new inf
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41

Arba, Francesco, Grant Mair, Stephen Phillips, Peter Sandercock, and Joanna M. Wardlaw. "Improving Clinical Detection of Acute Lacunar Stroke." Stroke 51, no. 5 (2020): 1411–18. http://dx.doi.org/10.1161/strokeaha.119.028402.

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Background and Purpose— We aim to identify factors associated with imaging-confirmed lacunar strokes and improve their rapid clinical identification early after symptom onset using data from the IST-3 (Third International Stroke Trial). Methods— We selected patients likely to have lacunar infarcts as those presenting with: Oxfordshire Community Stroke Project lacunar syndrome; a random sample with National Institutes of Health Stroke Scale (NIHSS) score <7; and recent lacunar infarct identified on imaging by IST-3 central blinded expert panel. An independent reviewer rated brain scans of th
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42

Berg, J., R. Jablonowski, D. Nordlund, et al. "Decreased atrioventricular plane displacement after acute myocardial infarction yields a concomitant decrease in stroke volume." Journal of Applied Physiology 128, no. 2 (2020): 252–63. http://dx.doi.org/10.1152/japplphysiol.00480.2019.

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Acute myocardial infarction (AMI) can progress to heart failure, which has a poor prognosis. Normally, 60% of stroke volume (SV) is attributed to the longitudinal ventricular shortening and lengthening evident in the atrioventricular plane displacement (AVPD) during the cardiac cycle, but there is no information on how the relationship changes between SV and AVPD before and after AMI. Therefore, the aim of this study was to determine how SV depends on AVPD before and after AMI in two swine models. Serial cardiac magnetic resonance imaging was carried out before and 1–2 h after AMI in a microem
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43

Ospel, Johanna M., Nathaniel Rex, Karim Oueidat, et al. "Infarcts Due to Large Vessel Occlusions Continue to Grow Despite Near-Complete Reperfusion After Endovascular Treatment." Journal of Stroke 26, no. 2 (2024): 260–68. http://dx.doi.org/10.5853/jos.2023.02621.

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Background and Purpose Infarcts in acute ischemic stroke (AIS) patients may continue to grow even after reperfusion, due to mechanisms such as microvascular obstruction and reperfusion injury. We investigated whether and how much infarcts grow in AIS patients after near-complete (expanded Thrombolysis in Cerebral Infarction [eTICI] 2c/3) reperfusion following endovascular treatment (EVT), and to assess the association of post-reperfusion infarct growth with clinical outcomes.Methods Data are from a single-center retrospective observational cohort study that included AIS patients undergoing EVT
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44

Moore, Alastair, Harold Goerne, Prabhakar Rajiah, Yuki Tanabe, Sachin Saboo, and Suhny Abbara. "Chronic Infarcts and Mimickers of Infarcts." Radiologic Clinics of North America 57, no. 1 (2019): 57–65. http://dx.doi.org/10.1016/j.rcl.2018.08.007.

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45

Dorrance, Anne M., Heather L. Osborn, Roger Grekin, and R. Clinton Webb. "Aldosterone Antagonism and Epidermal Growth Factor in Cerebral Ischemia." Hypertension 36, suppl_1 (2000): 723. http://dx.doi.org/10.1161/hyp.36.suppl_1.723-b.

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P166 Two factors that may contribute to the vascular remodeling involved in the pathogenesis of ischemic cerebrovascular disease are aldosterone (aldo) and epidermal growth factor (EGF). Spironolactone (spir) is known to reduce the frequency of hemorrhagic infarcts, its effects on ischemic infarcts are unknown. We have previously shown that the mRNA for EGF and its receptor (EGFR) are increased in the cerebral blood vessels from stroke-prone spontaneously hypertensive rats (SHRSP) compared to Wistar Kyoto (WKY) rats. We hypothesized that this, along with an altered response to aldo would contr
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46

Yedavalli, Vivek, and Elizabeth Tong. "The Potential Utility of Arterial Spin Labeling in Detecting and Localizing Posterior Circulation Occlusions in Every Day Practice: A Clinical Report of Selected Cases." Journal of Clinical Imaging Science 10 (December 10, 2020): 78. http://dx.doi.org/10.25259/jcis_118_2020.

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Arterial spin labeling (ASL) is a non-contrast, non-invasive method used for the evaluation of cerebral perfusion, which is now increasingly utilized in everyday clinical practice. As a marker of cerebral blood flow at the capillary level, it has particular utility in stroke assessment. One rarer stroke subtype with non-specific symptomatology that can lead to significant morbidity is the posterior circulation (PC) infarct. As with the more common anterior circulation infarcts, ASL has shown benefit in PC infarcts as well, but has not been extensively explored in the literature nor been direct
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47

Leary, Megan C., and Jeffrey L. Saver. "Incidence of Silent Stroke in the United States." Stroke 32, suppl_1 (2001): 363. http://dx.doi.org/10.1161/str.32.suppl_1.363-b.

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P134 Background: Recent estimates of stroke incidence in the US range from 715,000–750,000 annually. These estimates, however, do not reflect silent infarcts and hemorrhages. Since population-based studies have found that prevalence of silent stroke is 10–20 times that of symptomatic, estimates of stroke incidence based solely on symptomatic events may substantially underestimate the annual burden of stroke. Silent strokes contribute to vascular dementia, gait impairment, and other major adverse patient outcomes. Methods: Incidence of silent infarcts for different age strata were derived from
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Berger, Asaf, Garry Tzarfati, Mathias Costa, et al. "NCMP-05. THE INCIDENCE AND IMPACT OF POST-OPERATIVE STROKE IN SURGERY FOR LGG." Neuro-Oncology 21, Supplement_6 (2019): vi180. http://dx.doi.org/10.1093/neuonc/noz175.751.

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Abstract BACKGROUND Postoperative neurological deficits may outweigh the benefit conferred by maximal resection of gliomas. We evaluated the incidence of ischemic events in patients undergoing surgery for low-grade gliomas (LGG) and the long-term neurological and cognitive sequelae. METHODS Between 2013–2017, 168 patients underwent surgical resection or biopsy for LGG at our center. A full dataset, including pre- and postoperative magnetic resonance imaging (MRI) and long-term clinical evaluation findings, was available for 82 patients (study group). Ischemic complications, overall and progres
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Strouse, John J., Michael Kraut, Lisa M. Williams, Michael R. DeBaun, and James F. Casella. "Low Levels of Apolipoprotein A1 Are Associated with Silent Cerebral Infarcts in Children with Sickle Cell Disease." Blood 114, no. 22 (2009): 259. http://dx.doi.org/10.1182/blood.v114.22.259.259.

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Abstract Abstract 259 Background: Cerebral infarct is a frequent complication in children and adults with sickle cell disease (SCD). About 10% of children with sickle cell anemia (HbSS) will have an overt stroke by 18 years of age and another 22% will have “silent” cerebral infarcts by 14 years of age. There is a second peak in the incidence of overt ischemic stroke in adults with SCD. Both silent and overt stroke can be accompanied by cognitive impairment and thereby increased risk of academic failure. Several laboratory parameters have been associated with these complications, including low
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Ospel, Johanna, Michael D. Hill, Nima Kashani, et al. "Abstract P485: Predictors and Clinical Impact of Deep Grey Matter Infarction After Endovascular Treatment for Large Vessel Occlusion Stroke: Results From the Escape-NA1 Trial." Stroke 52, Suppl_1 (2021). http://dx.doi.org/10.1161/str.52.suppl_1.p485.

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Purpose: In this post-hoc analysis of the ESCAPE-NA1 trial, we investigated the prevalence of deep grey matter infarcts and their influence on clinical outcome. Methods: Infarcts on 24 hour follow up imaging (non contrast head CT or diffusion-weighted MRI) were categorized as predominantly deep grey matter infarcts (caudate and/or lentiform nucleus infarcts with sparing of the superficial grey matter and white matter) vs. other infarcts. Total infarct volume was manually segmented in all patients. When MRI follow-up was available, deep grey matter and grey matter infarct volumes were segmented
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