Journal articles: 'Infections à Helicobacter'

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Suwarni, Sri, Cilmiaty Risya, Dono Indarto, and Suradi Pulmonology. "Helicobacter Pylori is associated with decrease serum level of the thyroid hormonal in healthy elderly population." Bangladesh Journal of Medical Science 16, no. 4 (August 19, 2017): 515–20. http://dx.doi.org/10.3329/bjms.v16i4.33604.

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Background: Helicobacter pylori infection is the most prevalence infectious disease as it affects more than half of the world population and causes chronic cellular inflammatory response in the gastric mucosa. Helicobacter pylori infection has been epidemiologically proven to be linked to extra-digestive conditions and disease. It has been speculated that H.pylori infection may be responsible for various endocrine disorders. The thyroid may be one of the targets of Helicobacter pylori chronic inflammation. Here we sought too investigate whether H.pylori infections were associated with decrease level of the thyroid hormonal.Methods: This study involved elderly aged 50-90 years who had visited a health promotion center for elderly. A total 101 euthyroid subjects were been enrolled in this cross-sectional study. Diagnosed of Helicobacter.pylori infections by ELISA of Ig G antibodies of Helicobacter pylori. We examine serum T3 level and serum TSH level by ELEXIS. For statistical method we use Pearson bivariat analysis to determine the association of two variable,and linier regression to determine which variable is more influented by Helicobacter pylori.Results: Fourty-two (41,6 %) subjects had been diagnosed with H.pylori infections. Pearson bivariat analysis showed that Helicobacter pylori infection was significantly associated with decreased serum T3 level ( correlations coefficient r = -0,66 ,p< 0,001 ). The prevalence of Helicobacter pylori infection showed a increasing trend as serum TSH level decreased (correlations coefficient r = -0,53, p < 0,001). Linier regression analysis showed thatHelicobacter pylori infection was significantly associated with the risk of decreased thyroid hormonal fuction ( B = -0,272. R2 = 0,676. P < 0.001 ).Conclusion: Our results suggested that H.pylori infections were significantly associated with the decreased serum level of T3 and TSH serum level in the healthy elderly population, whose thyroid functions were in the reference range.Bangladesh Journal of Medical Science Vol.16(4) 2017 p.515-520

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Khazaei, Zaher, Yousef Moradi, Hossein Ali Adineh, F. Rezaei, Malihe Sohrabivafa, Isan Darvishi, Seyedeh Leila Dehghani, and Elham Goodarzi. "Cancers Attributable to Infectious Agents: an Ecological Study in Asia." Asian Pacific Journal of Environment and Cancer 1, no. 1 (November 26, 2018): 35–40. http://dx.doi.org/10.31557/apjec.2018.1.1.35-40.

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Infections are a major contributor to cancer, especially in developing countries. Infections through the virus, bacteria and parasites are the most and most preventable causes of cancer in the world. The aim of the current study was to investigate the epidemiology of cancer-related infections in Asia. We considered 4 infectious agents classified as carcinogenic to human beings by the International Agency for Research on Cancer. We calculated the number of new cancer cases in 2012 attributable to infections by country, by combining cancer incidence estimates (from GLOBOCAN 2012) with the estimates of attributable fraction (AF) for the infectious agents. AF estimates were calculated from the prevalence of infection in cancer cases for the infection (for some sites). According to data registered in 2012, about 14 million new cases of cancer were detected worldwide of which 2. 2 million people (15.4%) diagnosed with cancer due to infection. The highest incidence of infectious cancers related to the African continent with a prevalence of 27.6% followed by Asian continents (21.4%), America (7.9%), Europe (7.3%) and Oceania (4.8%), respectively. In the Asian continent, of all cancers associated with infection in males, 48.1% were related to Helicobacter pylori infection, 33.2% of hepatitis B virus, 8% of hepatitis C and 3.3% of HPV and in women 47.4% HPV, 28.7% Helicobacter pylori, 15.3% Hepatitis B and 4.5% Hepatitis C, respectively. India (230,000 cases) and Japan (140,000 cases) were the most affected, while Bahrain (86 cases) and Brunei (88 cases) had the least cases of infection-related cancer. in Asia, the most common cancer-related infection in males and females were reported for Helicobacter pylori and HPV, respectively. Therefore, with preventive interventions aimed at reducing these infections, the burden of cancers can be reduced.

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Haesebrouck, Freddy, Frank Pasmans, Bram Flahou, Koen Chiers, Margo Baele, Tom Meyns, Annemie Decostere, and Richard Ducatelle. "Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health." Clinical Microbiology Reviews 22, no. 2 (April 2009): 202–23. http://dx.doi.org/10.1128/cmr.00041-08.

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SUMMARY Helicobacters other than Helicobacter pylori have been associated with gastritis, gastric ulcers, and gastric mucosa-associated lymphoid tissue lymphoma in humans. These very fastidious microorganisms with a typical large spiral-shaped morphology were provisionally designated “H. heilmannii,” but in fact they comprise at least five different Helicobacter species, all of which are known to colonize the gastric mucosa of animals. H. suis, which has been isolated from the stomachs of pigs, is the most prevalent gastric non-H. pylori Helicobacter species in humans. Other gastric non-H. pylori helicobacters colonizing the human stomach are H. felis, H. salomonis, H. bizzozeronii, and the still-uncultivable “Candidatus Helicobacter heilmannii.” These microorganisms are often detected in the stomachs of dogs and cats. “Candidatus Helicobacter bovis” is highly prevalent in the abomasums of cattle but has only occasionally been detected in the stomachs of humans. There are clear indications that gastric non-H. pylori Helicobacter infections in humans originate from animals, and it is likely that transmission to humans occurs through direct contact. Little is known about the virulence factors of these microorganisms. The recent successes with in vitro isolation of non-H. pylori helicobacters from domestic animals open new perspectives for studying these microorganisms and their interactions with the host.

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Bertholom, Chantal. "Infections à Helicobacter pylori." Option/Bio 26, no. 521 (February 2015): 13–15. http://dx.doi.org/10.1016/s0992-5945(15)30025-8.

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Butzler, Jean-Paul, Youri Glupczynski, and Herman Goossens. "Campylobacter and helicobacter infections." Current Opinion in Infectious Diseases 5, no. 1 (February 1992): 80–87. http://dx.doi.org/10.1097/00001432-199202000-00014.

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Terry, Karianne, Susan M. Williams, Lynn Connolly, and Karen M. Ottemann. "Chemotaxis Plays Multiple Roles during Helicobacter pylori Animal Infection." Infection and Immunity 73, no. 2 (February 2005): 803–11. http://dx.doi.org/10.1128/iai.73.2.803-811.2005.

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ABSTRACT Helicobacter pylori is a human gastric pathogen associated with gastric and duodenal ulcers as well as specific gastric cancers. H. pylori infects approximately 50% of the world's population, and infections can persist throughout the lifetime of the host. Motility and chemotaxis have been shown to be important in the infection process of H. pylori. We sought to address the specific roles of chemotaxis in infection of a mouse model system. We found that mutants lacking cheW, cheA, or cheY are all nonchemotactic and infect FVB/N mice with an attenuated phenotype after 2 weeks of infection. If infections proceeded for 6 months, however, this attenuation disappeared. Histological and culture analysis revealed that nonchemotactic mutants were found only in the corpus of the stomach, while the wild type occupied both the corpus and the antrum. Further analysis showed that nonchemotactic H. pylori isolates had an increased 50% infectious dose and were greatly outcompeted when coinfected with the wild type. If nonchemotactic mutants were allowed to establish an infection, subsequent infection with the wild type partially displaced the nonchemotactic mutants, indicating a role for chemotaxis in maintenance of infection. The data presented here support four roles for chemotaxis in H. pylori mouse infections: (i) establishing infection, (ii) achieving high-level infection, (iii) maintaining an infection when there are competing H. pylori present, and (iv) colonizing all regions of the stomach.

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Jacobsen, K., E. Mahabir, M. Brielmeier, P. Wilhelm, K. E. Seidel, and J. Schmidt. "Monitoring a mouse colony for Helicobacter bilis using a Helicobacter-genus-specific nested PCR." Laboratory Animals 39, no. 4 (October 1, 2005): 400–412. http://dx.doi.org/10.1258/002367705774286402.

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Although Helicobacter infections of laboratory mice are usually subclinical, they may interfere with in vivo experiments and thus may lead to misinterpretation of data. As such, it is important to provide a means to unequivocally identify infections with murine Helicobacter spp. In the present study, a nested polymerase chain reaction (PCR) was established and shown to be 10 to 100 times more sensitive than the single-step PCR commonly used for routine diagnosis of Helicobacter spp. Experimental infection of Helicobacter-free mice demonstrated that faeces, caecum, colon and rectum but not liver are equally suitable for the detection of H. bilis. However, use of faecal pellets is advantageous since detection of H. bilis is possible one week after infection and analysis of faeces instead of tissues avoids euthanasia of animals. Furthermore, it generates representative data for all animals housed in the same cage and analysis can be repeatedly performed. Use of samples from breeding pairs but not offspring provides representative information about the Helicobacter status of a mouse colony. Both C3H/HeJ and C57BL/6 mice appear to be susceptible to H. bilis and persistent infection was observed during the 20-week experimental period. Analysis of pooled faecal pellets by nested PCR seems to be the most sensitive approach for H. bilis monitoring of the given breeding colony.

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Youssef, Ahmed, Ahmed Afifi, Ayman Hamed, and Mohamed Enany. "First report of PCR-based detection of Helicobacter species DNA in Camelus dromedarius in Egypt." Veterinary World 13, no. 9 (2020): 1898–901. http://dx.doi.org/10.14202/vetworld.2020.1898-1901.

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Background and Aim: Helicobacter species infections have epidemiological and zoonotic impacts, and different species of Helicobacter have been implicated in infecting humans and animals. The aim of this study was to investigate Helicobacter species infections in Camelus dromedarius. Materials and Methods: Fecal samples were collected from 32 camels from 9 camel farms located at Ismailia Governorate, Egypt. The collected samples were investigated by bacteriological isolation and conventional polymerase chain reaction (PCR) assays targeting the 16S ribosomal RNA gene. Results: Although Helicobacter species could not be isolated from all the examined samples, Helicobacter DNA was detected in 2 (22.22%) of the 9 camel farms. Of the 32 camel fecal samples examined, 4 (12.5%) were positive for Helicobacter species as analyzed by the PCR assay. Conclusion: To the best of our knowledge, this is the first report of PCR-based detection of Helicobacter species infections in C. dromedarius. Further epidemiological studies are required to clarify Helicobacter species infections in camels.

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Lauritano, Moreo, Carinci, Lucchese, Stasio, Vella, and Petruzzi. "Helicobacter Pylory and Oral Diseases." Proceedings 35, no. 1 (December 10, 2019): 16. http://dx.doi.org/10.3390/proceedings2019035016.

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Helicobacter pylori (H. pylori) gastric infection is considered one of the most common human infections. It occurs in half of the world’s population is the most common cause of adenocarcinoma of the distal stomach [1]. [...]

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Litvinova, Ekaterina A., Elena N. Kozhevnikova, Ksenia M. Achasova, Galina V. Kontsevaya, and Mikhail P. Moshkin. "Eradication of Helicobacter spp. in mucin2-deficient mice." Laboratory Animals 51, no. 3 (September 29, 2016): 311–14. http://dx.doi.org/10.1177/0023677216670687.

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Infections with Helicobacter spp. are known to have serious effects on rodent health, especially in immunocompromised animals. In this study three approaches were used to eradicate Helicobacter spp. infection in mice with a deficiency in intestinal proteoglycan (mucin2), namely triple oral antibiotic therapy (amoxicillin, clarithromycin and metronidazole), cross-fostering of neonatal pups by surrogate mothers negative for Helicobacter spp., and in vitro fertilization (IVF) with embryo transfer into Helicobacter-free mothers. However, triple antibiotic therapy in mice with mucin2 deficiency was not effective and had negative effects on reproductive performance, and high susceptibility of mucin2-deficient mice to Helicobacter spp. during the first 12 h after birth rendered cross-fostering impossible. Only IVF with embryo transfer was effective in eradicating Helicobacter infection from transgenic mice with mucin2 deficiency.

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Paradowski, Leszek. "Helicobacter pylori – a still ongoing problem." Medycyna Faktów 13, no. 4 (December 31, 2020): 491–95. http://dx.doi.org/10.24292/01.mf.0420.17.

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The diagnosis and treatment of Helicobacter pylori infection are up-to-date, which is due to the frequency of human infections and the consequences of the chronic once, in most cases Helicobacter pylori infection is asymptomatic. If there are symptoms, the most common are dyspeptic complaints. In some patients Helicobacter pylori causes severe disease, mainly in stomach. This pathogen has been recognized as the main cause of the peptic ulcer, gastric cancer and MALT lymphoma. It is also known to play an important role in some other disease such essential thrombocytopenia, some types of deficiency anemia. This article discusses the current on the epidemiology of Helicobacter pylori infection, its consequences, diagnosis, treatment and the prevention of infection, information on changes in flora of digestive tract that can occur during the eradication of this bacterium, is also presented.

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Bumann, Dirk, Petra Holland, Frank Siejak, Jan Koesling, Nicolas Sabarth, Stefanie Lamer, Ursula Zimny-Arndt, Peter R. Jungblut, and Thomas F. Meyer. "A Comparison of Murine and Human Immunoproteomes of Helicobacter pylori Validates the Preclinical Murine Infection Model for Antigen Screening." Infection and Immunity 70, no. 11 (November 2002): 6494–98. http://dx.doi.org/10.1128/iai.70.11.6494-6498.2002.

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ABSTRACT Preclinical mouse infection models are widely used for Helicobacter vaccine development, but how well such models mimic important aspects of human infections is unknown. A comparison of Helicobacter pylori immunoproteomes of infected mice with previously reported patient data reveals a high agreement in the antigens recognized, suggesting that H. pylori in vivo protein composition and recognition by the host immune system are comparable in mice and humans. Murine Helicobacter models may thus be valid to screen antigens for human vaccination.

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Jankowski, M., J. Spużak, K. Kubiak, K. Glińska-Suchocka, and M. Biernat. "Detection of Helicobacter spp. in the saliva of dogs with gastritis." Polish Journal of Veterinary Sciences 19, no. 1 (March 1, 2016): 133–40. http://dx.doi.org/10.1515/pjvs-2016-0017.

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AbstractThe aim of this study was to identify the species and determine the prevalence of gastric Helicobacter in the saliva of dogs with gastritis. The study was carried out on 30 dogs of different breeds, genders and ages, which were diagnosed with gastritis. The nested-PCR method was used to detect Helicobacter spp. in saliva. Helicobacter bacteria were found in the saliva samples of 23 (76.6%) dogs. Helicobacter heilmannii was the most commonly detected species of gastric Helicobacter spp. in canine saliva, and was found in 22 (73.3%) cases. The results indicate that gastric Helicobacter spp. occurs relatively frequently in dogs with gastritis. Moreover, the saliva of dogs with gastritis may be a source of Helicobacter spp. infection for humans and other animals. However, further studies are needed to confirm this finding as the PCR method does not distinguish active from inactive infections.

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Brady, R. C. "Persistent and Transient Helicobacter pylori Infections." AAP Grand Rounds 34, no. 5 (November 1, 2015): 58. http://dx.doi.org/10.1542/gr.34-5-58.

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Mégraud, Francis, and Philippe Lehours. "Helicobacter pylori : diagnostic bactériologique des infections." EMC - Biologie Médicale 1, no. 2 (January 2006): 1–4. http://dx.doi.org/10.1016/s2211-9698(06)76477-9.

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Rimbara, Emiko, Lori A. Fischbach, and David Y. Graham. "Optimal therapy for Helicobacter pylori infections." Nature Reviews Gastroenterology & Hepatology 8, no. 2 (February 2011): 79–88. http://dx.doi.org/10.1038/nrgastro.2010.210.

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Kusters, Johannes G., and Ernst J. Kuipers. "Non-pylori Helicobacter infections in humans." European Journal of Gastroenterology & Hepatology 10, no. 3 (March 1998): 239–42. http://dx.doi.org/10.1097/00042737-199803000-00009.

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Graham, D. Y., and L. A. Fischbach. "Empiric therapies for Helicobacter pylori infections." Canadian Medical Association Journal 183, no. 9 (February 22, 2011): E506—E508. http://dx.doi.org/10.1503/cmaj.101460.

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Mégraud, Francis. "Diagnostic des infections à Helicobacter pylori." Annales de l'Institut Pasteur / Actualités 6, no. 3 (January 1995): 179–84. http://dx.doi.org/10.1016/0924-4204(96)89256-0.

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Ly, A. "Infections à Helicobacter pylori et oncogenèse." Journal Africain du Cancer / African Journal of Cancer 2, no. 4 (October 18, 2010): 213–18. http://dx.doi.org/10.1007/s12558-010-0123-z.

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DIACONESCU, Smaranda, Marin BURLEA, Raluca STANCA, Monica ALEXOAE, and Ileana IONIUC. "Triple gastric ulcer in young child – case presentation." Romanian Journal of Medical Practice 10, no. 4 (December 31, 2015): 394–96. http://dx.doi.org/10.37897/rjmp.2015.4.14.

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Peptic ulcer is represented by loss of gastric or duodenal mucosal substance. It’s been considered a rare disease at the paediatric age. The main cause is represented by Helicobacter pylori infections or drugs administration. The authors present a case of nine-year-old child with triple gastric ulcer without Helicobacter pylori infection or prior treatment with nonsteroidal anti-inflammatory drugs or other medication with possible impact.

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&NA;. "Helicobacter pylori and other Helicobacter spp. chronic infections and extragastric diseases." European Journal of Gastroenterology & Hepatology 12, no. 9 (September 2000): 1057–60. http://dx.doi.org/10.1097/00042737-200012090-00020.

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Suárez-Esquivel, Marcela, and Elías Barquero-Calvo. "Carta al Editor Es erróneo hacer una asociación directa entre la detección de Helicobacter spp. y gastritis en caninos." Revista Ciencias Veterinarias 35, no. 2 (December 3, 2017): 61. http://dx.doi.org/10.15359/rcv.35-2.1.

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It has been proposed that Helicobacter may play a significant role in the generation of gastritis and cancer in dogs. However, despite several independent efforts, there is still controversy regarding the true ability of Helicobacter to cause gastric lesions in these animals. The foregoing is due in part to the fact that gastritis is a multifactorial disease. Studies focused on naturally acquired infections have been unable to establish a positive correlation between Helicobacter colonization and gastritis. Establishing a clear association between the presence of Helicobacter and gastritis may be difficult due to the following reasons: (i) taxonomy of the genus Helicobacter remains unclear, (ii) virulence factors of Helicobacter species that colonize dogs are not well known, and (iii) simultaneous infections have been reported with several species of Helicobacter. Current knowledge in taxonomy and pathogenesis of Helicobacter species is insufficient to differentiate between pathogenic and non-pathogenic strains. Therefore, no direct association should be made between the detection of Helicobacter and gastritis.

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Croitoru, Ken. "Immunomodulation of Helicobacter Infection." Canadian Journal of Gastroenterology 13, no. 3 (1999): 237–41. http://dx.doi.org/10.1155/1999/839194.

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Helicobacter pylorileads to a chronic infection in humans that is associated with gastric inflammation and a vigorous immune response. Despite the humoral and cellular responses that can be detected in both human and animal models of helicobacter infection, the immune response fails to eliminate the organism. Eradication failure may be due to the niche in whichH pyloriconfines itself, well away from direct contact with elements of the immune system. Alternatively, the general tendency of the intestinal immune response to down- regulate reactivity to noninvasive luminal bacteria also may contribute to the failure to eliminatehelicobacterinfection. Results of vaccine studies in mouse models indicate that modulating the helper T cell response from a T helper cell type 1 to a T helper cell type 2 response likely is required for the prevention and elimination of helicobacter infection. Understanding the mechanisms by which the immune response controls bacterial infections will allow for the design of novel strategies of immune modulation and the development of vaccines for both the treatment and prevention ofH pylori.

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Mégraud, Francis, and Philippe Lehours. "Helicobacter pylori Detection and Antimicrobial Susceptibility Testing." Clinical Microbiology Reviews 20, no. 2 (April 2007): 280–322. http://dx.doi.org/10.1128/cmr.00033-06.

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SUMMARY The discovery of Helicobacter pylori in 1982 was the starting point of a revolution concerning the concepts and management of gastroduodenal diseases. It is now well accepted that the most common stomach disease, peptic ulcer disease, is an infectious disease, and all consensus conferences agree that the causative agent, H. pylori, must be treated with antibiotics. Furthermore, the concept emerged that this bacterium could be the trigger of various malignant diseases of the stomach, and it is now a model for chronic bacterial infections causing cancer. Most of the many different techniques involved in diagnosis of H. pylori infection are performed in clinical microbiology laboratories. The aim of this article is to review the current status of these methods and their application, highlighting the important progress which has been made in the past decade. Both invasive and noninvasive techniques will be reviewed.

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Rengaswamy, Ramapriya, and Thayumanavan I. "Incidence and profile of Helicobacter pylori infection among HIV positive patients." International Journal of Advances in Medicine 5, no. 5 (September 22, 2018): 1299. http://dx.doi.org/10.18203/2349-3933.ijam20183912.

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Background: People having HIV infection present with a number of symptoms related to gastrointestinal tract like dyspepsia. HIV itself as well as opportunistic infections is responsible for such symptoms. Notably is Helicobacter pylori infection causes variety of such symptoms. The objective of the present research was to study incidence and profile of Helicobacter pylori among HIV positive patients.Methods: A hospital based cross sectional study was carried out over a period of two years among 101 HIV positive patients in the Department of General Medicine, Madurai Medical College, Madurai in collaboration with Department of Medical Gastroenterology and also Department of Venereology and Leporology. Rapid urease test was done. HIV status was confirmed by ELISA test. Data was analysed with the help of EPI statistical software.Results: Majority (40.6%) had CD4 count of 200-500. It has been observed that incidence of Helicobacter pylori was low in groups with low CD4 count. It was also observed that those with higher CD4 count had higher incidence of RUT positivity. This association was found to be statistically significant. The incidence of Helicobacter pylori positivity was not significantly different among those patients who were on ART (18%) and those who were not on ART (21%).Conclusions: The incidence of Helicobacter pylori infection was less in HIV positive patients. Those with CD4 cell count less than 100 had lower incidence of Helicobacter pylori infection than those with CD 4 cell count more than 500. Incidence of Helicobacter pylori infection was not affected by ART.

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Kuntoji, Shrikanth B., Ankita A. Naik, and Suhas D. S. "A prospective study of proportion of Helicobacter pylori infection in patients presenting with dyspeptic symptoms in S. Nijalingappa Medical College and H.S.K. Hospital, Bagalkot." International Surgery Journal 7, no. 8 (July 23, 2020): 2685. http://dx.doi.org/10.18203/2349-2902.isj20203255.

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Background: More than half of the world’s population is infected with Helicobacter pylori, the primary cause of chronic gastritis. Chronic gastritis is associated with peptic ulcer and in advanced stages with an increased risk of developing gastric adenocarcinoma. The aim of the study was to determine the prevalence of Helicobacter pylori infection in dyspeptic patients and its relationship with gastroduodenal pathologies using gastric biopsy histology.Methods: A cross sectional prospective study was conducted from 1st January 2018 to 30th June 2019. It included out-patients and in-patients, presenting with dyspeptic symptoms and undergoing upper GI Endoscopy, at S. Nijalingappa Medical College and HSK hospital, Bagalkot, Karnataka, India. Endoscopic impressions were noted. In case of any abnormal findings on upper gastrointestinal endoscopy, endoscopic biopsy was obtained. Histopathological assessment of gastric mucosa was done after staining with H and E stain and Giemsa stain. The histopathological diagnosis of Helicobacter pylori infection in biopsy specimen will be mainly done using the Modified Giemsa stain.Results: 105 patients with dyspepsia were studied in total. Out of which, 44 patients (41.9%) were detected positive for Helicobacter pylori infection.Conclusions: The burden of Helicobacter pylori infection in patients with dyspepsia was high. Early diagnosis and eradication of Helicobacter pylori not only improves symptoms but also help to prevent complications associated with Helicobacter pylori infections.

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Krause, Martin. "Emerging antibiotic resistance in gastrointestinal infections." Therapeutische Umschau 59, no. 1 (January 1, 2002): 36–40. http://dx.doi.org/10.1024/0040-5930.59.1.36.

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Resistenzentwicklungen machen auch bei pathogenen Bakterien gastrointestinaler Infektionen nicht Halt. So sind vor allem bei Salmonellen, Campylobacter und Helicobacter pylori in den letzten zehn Jahren eine mehrfache Erhöhung der Resistenzquoten gegen bisher erfolgreiche Antibiotika beobachtet worden. Die bedeutendsten Entwicklungen sind die Resistenzzunahme gegen Metronidazol und Clarithromycin bei Helicobacter pylori, gegen Fluorochinolone und Makrolide bei Campylobacter und gegen Fluorochinolone und Drittgeneration-Cephalosporine bei Salmonellen. Besonders besorgniserregend sind Mehrfachresistenzen, die bei allen drei Bakteriengenera vorkommen. Erfreulicherweise ist die Resistenzrate von Clostridium difficile gegen Metronidazol und Vancomycin noch sehr gering. Es bestehen keine Zweifel, dass der weit verbreitete Antibiotika-Einsatz in der Fleisch- und Geflügelindustrie die Quelle resistenter Campylobacter und Salmonellen ist. Vor allem in diesem Sektor ist eine rigorose Kontrolle und Reduktion des Antibiotika-Verbrauchs notwendig, um den aktuellen Trend zu bremsen. Folgende Regeln sind bei diesen drei «Problemkeimen» zu beachten: 1) restriktiver Antibiotika-Gebrauch, der auf etablierten Therapieindikationen beruht. Die Eradikation eines symptomlosen Helicobacter ist nicht indiziert und Antibiotika beeinflussen den Krankheitsverlauf bei den meisten Campylobacter- und Salmonella-Enterokolitiden nicht. 2) Antibiotika gezielt gegen den identifizierten Erreger, kurz und in richtiger Dosierung einsetzen. 3) Resistenzprüfungen durchführen, welche die richtige Antibiotikawahl ermöglichen und verhindern, dass wirkungslose Therapien durchgeführt werden, die lediglich die Resistenzbildung in der Bakterienflora fördern.

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Zeeb, Marius, Tobias Kerrinnes, Luka Cicin-Sain, Carlos A. Guzman, Wolfram Puppe, Thomas F. Schulz, Annette Peters, Klaus Berger, Stefanie Castell, and André Karch. "Seropositivity for pathogens associated with chronic infections is a risk factor for all-cause mortality in the elderly: findings from the Memory and Morbidity in Augsburg Elderly (MEMO) Study." GeroScience 42, no. 5 (July 9, 2020): 1365–76. http://dx.doi.org/10.1007/s11357-020-00216-x.

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Abstract Immunostimulation by chronic infection has been linked to an increased risk for different non-communicable diseases, which in turn are leading causes of death in high- and middle-income countries. Thus, we investigated if a positive serostatus for pathogens responsible for common chronic infections is individually or synergistically related to reduced overall survival in community dwelling elderly. We used data of 365 individuals from the German MEMO (Memory and Morbidity in Augsburg Elderly) cohort study with a median age of 73 years at baseline and a median follow-up of 14 years. We examined the effect of a positive serostatus at baseline for selected pathogens associated with chronic infections (Helicobacter pylori, Borrelia burgdorferi sensu lato, Toxoplasma gondii, cytomegalovirus, Epstein-Barr virus, herpes simplex virus 1/2, and human herpesvirus 6) on all-cause mortality with multivariable parametric survival models. We found a reduced survival time in individuals with a positive serostatus for Helicobacter pylori (accelerated failure time (AFT) − 15.92, 95% CI − 29.96; − 1.88), cytomegalovirus (AFT − 22.81, 95% CI − 36.41; − 9.22) and Borrelia burgdorferi sensu lato (AFT − 25.25, 95% CI − 43.40; − 7.10), after adjusting for potential confounders. The number of infectious agents an individual was seropositive for had a linear effect on all-cause mortality (AFT per additional infection − 12.42 95% CI − 18.55; − 6.30). Our results suggest an effect of seropositivity for Helicobacter pylori, cytomegalovirus, and Borrelia burgdorferi sensu lato on all-cause mortality in older community dwelling individuals. Further research with larger cohorts and additional biomarkers is required, to assess mediators and molecular pathways of this effect.

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Ward, Jerrold M. "Helicobacter Infections of Rodents and Carcinogenesis Bioassays." Toxicologic Pathology 25, no. 6 (November 1997): 590. http://dx.doi.org/10.1177/019262339702500608.

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Andersen, L. P. "Pathogenesis and host response in Helicobacter infections." FEMS Immunology & Medical Microbiology 30, no. 2 (March 1, 2001): 85. http://dx.doi.org/10.1111/j.1574-695x.2001.tb01553.x.

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SMITH, A. "Blood group antigens and Helicobacter pylori infections." Lancet 343, no. 8896 (February 1994): 543. http://dx.doi.org/10.1016/s0140-6736(94)91497-4.

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Perez-Perez, G. I., D. N. Taylor, L. Bodhidatta, J. Wongsrichanalai, W. B. Baze, B. E. Dunn, P. D. Echeverria, and M. J. Blaser. "Seroprevalence of Helicobacter pylori Infections in Thailand." Journal of Infectious Diseases 161, no. 6 (June 1, 1990): 1237–41. http://dx.doi.org/10.1093/infdis/161.6.1237.

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Cazzato, Immacolata Alessia, Marcello Candelli, Enrico Celestino Nista, Giovanni Gasbarrini, and Antonio Gasbarrini. "Role of probiotics in Helicobacter pylori infections." Scandinavian Journal of Nutrition 48, no. 1 (January 2004): 26–31. http://dx.doi.org/10.1080/11026480410026456.

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Krogfelt, Karen A., Leif Percival Andersen, and J. G. Kusters. "Pathogenesis and host response in Helicobacter infections." FEMS Immunology & Medical Microbiology 44, no. 2 (May 2005): 111. http://dx.doi.org/10.1016/j.femsim.2005.02.006.

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Ceelen, Liesbeth M., Annemie Decostere, Koen Chiers, Richard Ducatelle, Dominiek Maes, and Freddy Haesebrouck. "Pathogenesis of Helicobacter pullorum infections in broilers." International Journal of Food Microbiology 116, no. 2 (May 2007): 207–13. http://dx.doi.org/10.1016/j.ijfoodmicro.2006.12.022.

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Ferrero, Richard L. "Vaccination contre les infections à Helicobacter pylori." Annales de l'Institut Pasteur / Actualités 6, no. 3 (January 1995): 237–44. http://dx.doi.org/10.1016/0924-4204(96)89263-8.

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Capparelli, Rosanna, and Domenico Iannelli. "Genetics of Host Protection against Helicobacter pylori Infections." International Journal of Molecular Sciences 22, no. 6 (March 21, 2021): 3192. http://dx.doi.org/10.3390/ijms22063192.

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This narrative review discusses the genetics of protection against Helicobacter pylori (Hp) infection. After a brief overview of the importance of studying infectious disease genes, we provide a detailed account of the properties of Hp, with a view to those relevant for our topic. Hp displays a very high level of genetic diversity, detectable even between single colonies from the same patient. The high genetic diversity of Hp can be evaded by stratifying patients according to the infecting Hp strain. This approach enhances the power and replication of the study. Scanning for single nucleotide polymorphisms is generally not successful since genes rarely work alone. We suggest selecting genes to study from among members of the same family, which are therefore inclined to cooperate. Further, extending the analysis to the metabolism would significantly enhance the power of the study. This combined approach displays the protective role of MyD88, TIRAP, and IL1RL1 against Hp infection. Finally, several studies in humans have demonstrated that the blood T cell levels are under the genetic control of the CD39+ T regulatory cells (TREGS).

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Erginsoy, S. D., M. Sözmen, and K. Özcan. "Gastric Helicobacter-like Organisms in Stray Cats." Acta Veterinaria Brno 75, no. 1 (2006): 91–98. http://dx.doi.org/10.2754/avb200675010091.

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Ten adult domestic shorthaired stray cats (Felis catus) were investigated for the presence and localization of different species of gastric Helicobacter-like organisms (GHLOs) using Warthin-Starry silver staining, immunohistochemistry and transmission electron microscopy (TEM); the severity and distribution of lesions in different regions of the stomach were assessed in HE-stained sections. GHLOs were present in all areas of the stomach in all of 10 cats. Three morphologically different types of spiral-shaped bacteria were demonstrated; in silver-stained sections, H. pylori like organisms (HPLO) were easily differentiated from other GHLOs. Eight of the cats had H. heilmannii-like organisms (HHLOs) and one cat had HPLO. Mixed H. heilmannii and H. felis infection was seen in only one cat. GHLO infection was associated with a mild to severe gastritis in 8 of 10 cats. GHLOs colonized the cardia, corpus and antrum in similar density. The most striking histopathological changes consisted of accumulation of lymphocytes and neutrophilic granulocytes, fibrosis of the lamina propria mucosae, lymphoid follicles and lymphocytic infiltrates. There was no obvious relation between the degree of colonization by GHLOs and the extent of histopathological changes. GHLOs were present on the mucosal surface, in the lumen of gastric glands, and in the cytoplasm of parietal cells. These findings indicate that immunohistochemistry and silver staining are useful for detecting GHLO infections, particularly with different Helicobacter species present. Stray cats are frequently colonized by HHLOs without any significant correlation between the degree of infection and gastritis score; in contrast HPLOs and HFLOs infections are not very common.

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BOCIAN, KATARZYNA M., and ELŻBIETA K. JAGUSZTYN-KRYNICKA. "The Controversy over Anti-Helicobacter pylori Therapy." Polish Journal of Microbiology 61, no. 4 (2012): 239–46. http://dx.doi.org/10.33073/pjm-2012-033.

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Helicobacter pylori is a Gram-negative spiral-shaped bacterium, member of epsilon-Proteobacteria specifically colonizing the gastric epithelium of humans. It causes one of the most common infections worldwide, affecting about half of the world's population. However, it should be noted that the prevalence of H. pylori, particularly in the Western world, has significantly decreased coinciding with an increase of some autoimmune and allergic diseases, such as asthma. Various epidemiological studies have also documented a negative association between H. pylori colonization and the presence of GERD (gastroesophageal reflux disease) and risk of esophageal cancer. Additionally, an upward trend of obesity recently observed in inhabitants of developed countries raised a question about the relationship between H. pylori infection and the human body mass index. The first part of this review describes common, recommended anti-H. pylori treatments. The second part, presents the results of recent experiments aimed at evaluating the association between H. pylori infections and gastro-esophageal diseases, the level of stomach hormones, the human body mass index and allergic diseases. Although some studies suggest an inverse association of H. pylori infection with some health problems of the modern world such as asthma, obesity or GERD, H. pylori should be considered as a harmful human pathogen responsible for serious and sometimes lethal diseases. Thus, many scientists advocate the eradication of H. pylori.

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Szwed, Piotr, Aleksandra Gąsecka, Mateusz Zawadka, Ceren Eyileten, Marek Postuła, Tomasz Mazurek, Łukasz Szarpak, and Krzysztof J. Filipiak. "Infections as Novel Risk Factors of Atherosclerotic Cardiovascular Diseases: Pathophysiological Links and Therapeutic Implications." Journal of Clinical Medicine 10, no. 12 (June 8, 2021): 2539. http://dx.doi.org/10.3390/jcm10122539.

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Atherosclerotic cardiovascular diseases (ASCVD) are the major cause of mortality worldwide. Despite the continuous progress in ASCVD therapy, the residual risk persists beyond the management of traditional risk factors. Several infections including Helicobacter pylori infection, periodontal disease, and viral infections are associated with the increased risk of ASCVD, both directly by damage to the heart muscle and vasculature, and indirectly by triggering a systemic proinflammatory state. Hence, beyond the optimal management of the traditional ASCVD risk factors, infections should be considered as an important non-classical risk factor to enable early diagnosis and appropriate treatment. Here, we summarized the currently available evidence regarding the role of inflammation in ASCVD and the association between the particular infections and pathogens (Helicobacter pylori, periodontal disease, pneumonia, Cytomegalovirus, Human immunodeficiency virus, Herpes simplex virus, and severe acute respiratory syndrome coronavirus 2) on the development and progression of ASCVD. We also speculated about the potential therapeutic implications of the anti-inflammatory and anti-infective drugs on ASCVD outcomes, including drugs routinely administered in patients with ASCVD (statins, P2Y12 receptor inhibitors, and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers) and novel strategies aiming at residual risk reduction (colchicine, anti-cytokine drugs, and methotrexate). Considering the emerging association between infections and ASCVD, it is crucial to determine the possible advantages of infection prevention and treatment in patients with ASCVD.

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Hellemans, A., A. Decostere, F. Haesebrouck, and R. Ducatelle. "Evaluation of Antibiotic Treatment against “Candidatus Helicobacter suis” in a Mouse Model." Antimicrobial Agents and Chemotherapy 49, no. 11 (November 2005): 4530–35. http://dx.doi.org/10.1128/aac.49.11.4530-4535.2005.

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ABSTRACT “Helicobacter heilmannii” (proposed name) type 1 colonizes the human stomach. It has been shown to be identical to“ Candidatus Helicobacter suis,” a Helicobacter species colonizing the stomachs of >60% of slaughter pigs. This bacterium has not been isolated in vitro until now. Antibiotic susceptibility testing of “Candidatus Helicobacter suis” has not been carried out so far. For the present study, a mouse model was adopted to evaluate the antibiotic susceptibility of this organism. Mice infected with“ Candidatus Helicobacter suis” were treated with amoxicillin and omeprazole, a therapy which is used to treat H. heilmannii infections in humans. Two different isolates of“ Candidatus Helicobacter suis” were tested. The excretion of bacterial DNA was assessed during treatment, using PCR on fecal samples. At the end of the experiment, 8 days after the cessation of treatment, the presence of infection was evaluated using a urease test and a PCR test on stomach samples. A marked decrease in the excretion of bacterial DNA was observed a few days after the onset of treatment, and the level remained low until the end of the experiment. A difference in susceptibility between the two“ Candidatus Helicobacter suis” isolates was pointed out. The in vivo mouse model infected with“ Candidatus Helicobacter suis” will be useful for further screening of potential therapeutic regimens.

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Rojas García, Paula, Simon van der Pol, Antoinette D. I. van Asselt, Maarten Postma, Roberto Rodríguez-Ibeas, Carmelo A. Juárez-Castelló, Marino González, and Fernando Antoñanzas. "Efficiency of Diagnostic Testing for Helicobacter pylori Infections—A Systematic Review." Antibiotics 10, no. 1 (January 8, 2021): 55. http://dx.doi.org/10.3390/antibiotics10010055.

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Background: The most recommended treatment for a Helicobacter pylori infection is high doses of combined antibiotics. The objective of this article is to perform a systematic review of the economic evaluation studies applied to assess the efficiency of diagnostic testing for H. pylori infections, so that their main characteristics can be identified and to learn from the literature how the antimicrobial resistance (AMR) issue is incorporated into these economic evaluations. Methods: We conducted a systematic review to compare the costs and clinical effectiveness of diagnostic strategies for H. pylori infections. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and extracted the items from the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist. Results: We found thirteen articles that were of good quality according to CHEERS: six studies focused on diagnostics of Helicobacter pylori infections associated with dyspepsia and four on duodenal ulcers. Testing was found to be the most cost-effective strategy in eight articles. Four studies considered AMR. Conclusions: Testing was more cost-effective than empirical treatment, except in cases of high prevalence (as with developing countries) or when patients could be stratified according to their comorbidities. The introduction of AMR into the model may change the efficiency of the testing strategy.

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Rojas García, Paula, Simon van der Pol, Antoinette D. I. van Asselt, Maarten Postma, Roberto Rodríguez-Ibeas, Carmelo A. Juárez-Castelló, Marino González, and Fernando Antoñanzas. "Efficiency of Diagnostic Testing for Helicobacter pylori Infections—A Systematic Review." Antibiotics 10, no. 1 (January 8, 2021): 55. http://dx.doi.org/10.3390/antibiotics10010055.

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Background: The most recommended treatment for a Helicobacter pylori infection is high doses of combined antibiotics. The objective of this article is to perform a systematic review of the economic evaluation studies applied to assess the efficiency of diagnostic testing for H. pylori infections, so that their main characteristics can be identified and to learn from the literature how the antimicrobial resistance (AMR) issue is incorporated into these economic evaluations. Methods: We conducted a systematic review to compare the costs and clinical effectiveness of diagnostic strategies for H. pylori infections. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and extracted the items from the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist. Results: We found thirteen articles that were of good quality according to CHEERS: six studies focused on diagnostics of Helicobacter pylori infections associated with dyspepsia and four on duodenal ulcers. Testing was found to be the most cost-effective strategy in eight articles. Four studies considered AMR. Conclusions: Testing was more cost-effective than empirical treatment, except in cases of high prevalence (as with developing countries) or when patients could be stratified according to their comorbidities. The introduction of AMR into the model may change the efficiency of the testing strategy.

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Conley, Kenneth J., Tracie A. Seimon, Ioana S. Popescu, James F. X. Wellehan, James G. Fox, Zeli Shen, Jane Haakonsson, et al. "Systemic Helicobacter infection and associated mortalities in endangered Grand Cayman blue iguanas (Cyclura lewisi) and introduced green iguanas (Iguana iguana)." PLOS ONE 16, no. 2 (February 19, 2021): e0247010. http://dx.doi.org/10.1371/journal.pone.0247010.

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The Blue Iguana Recovery Programme maintains a captive breeding and head-starting program for endangered Grand Cayman blue iguanas (Cyclura lewisi) on Grand Cayman, Cayman Islands. In May 2015, program staff encountered two lethargic wild Grand Cayman blue iguanas within the Queen Elizabeth II Botanic Park (QEIIBP). Spiral-shaped bacteria were identified on peripheral blood smears from both animals, which molecular diagnostics identified as a novel Helicobacter species (provisionary name Helicobacter sp. GCBI1). Between March 2015 and February 2017, 11 Grand Cayman blue iguanas were identified with the infection. Two of these were found dead and nine were treated; five of the nine treated animals survived the initial infection. Phylogenetic analysis of the 16S rRNA gene suggests Helicobacter sp. GCBI1 is most closely related to Helicobacter spp. in chelonians. We developed a Taqman qPCR assay specific for Helicobacter sp. GCBI1 to screen tissue and/or blood samples from clinical cases, fecal and cloacal samples from clinically healthy Grand Cayman blue iguanas, including previously infected and recovered iguanas, and iguanas housed adjacent to clinical cases. Fecal and/or cloacal swab samples were all negative, suggesting that Grand Cayman blue iguanas do not asymptomatically carry this organism nor shed this pathogen per cloaca post infection. Retrospective analysis of a 2014 mortality event affecting green iguanas (Iguana iguana) from a separate Grand Cayman location identified Helicobacter sp. GCBI1 in two of three cases. The source of infection and mode of transmission are yet to be confirmed. Analysis of rainfall data reveal that all infections occurred during a multi-year dry period, and most occurred shortly after the first rains at the end of seasonal drought. Additionally, further screening has identified Helicobacter sp. GCBI1 from choanal swabs of clinically normal green iguanas in the QEIIBP, suggesting they could be asymptomatic carriers and a potential source of the pathogen.

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Sawleshwarkar, S., G. Eslick, C. Chung, R. Jones, and A. Mindel. "22. IS HELICOBACTER PYLORI A STI? - A PILOT STUDY." Sexual Health 4, no. 4 (2007): 293. http://dx.doi.org/10.1071/shv4n4ab22.

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Background: Helicobacter pylori is responsible for chronic gastritis and peptic ulcer disease and is associated with an increased risk of developing stomach cancer. The seroprevalence of Helicobacter pylori in the Australian-born adult population is about 20% and increases with age. The exact mode of transmission of Helicobacter pylori infection remains unknown and it has been suggested that sexual transmission may be important. This study is a preliminary investigation into a possible association between sexual risk factors and Helicobacter pylori infection. Subjects and methods: All patients aged 18 and above, presenting to the Parramatta Sexual Health Clinic and were having blood taken for any other purpose, were eligible for the study. Blood samples were collected for Helicobacter pylori serology using an enzyme-linked immunosorbent assay to detect Helicobacter pylori IgG. Demographic information and data regarding sexual behaviour and risk factors for sexually transmitted infections was obtained. The sample size to detect a 15% difference between the study population and the general Australian population with 90% power was 105. To allow for minor variations we plan to recruit 125 participants. Results: To date, 65 patients (75.4% males) have been enrolled in the study and 10 (7 males and 3 females) (15.4%) were positive for Helicobacter pylori. One additional result was equivocal. 24.6% of the participants were born outside Australia and out of 8 who belonged to middle and low-income countries, three had positive serology. The full results of the study, including seroprevalence and the demographic and sexual risk factors, will be presented.

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Khoder, Ghalia, Sara Mina, Ibrahim Mahmoud, Jibran Sualeh Muhammad, Rania Harati, and Christophe Burucoa. "Helicobacter pylori Infection in Tripoli, North Lebanon: Assessment and Risk Factors." Biology 10, no. 7 (June 28, 2021): 599. http://dx.doi.org/10.3390/biology10070599.

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Helicobacter pylori (H. pylori) infection occurs among half of the general population worldwide, with high geographic variability. Even though H. pylori is the leading cause of several gastric diseases, ranging from gastritis and peptic ulcers to gastric malignancies, such as gastric cancer and mucosa-associated lymphoid tissue lymphoma, most of the infections remain asymptomatic. Early detection and eradication of H. pylori can definitely prevent severe long-term gastric diseases associated with H. pylori. In Lebanon, the prevalence of H. pylori is not well documented, especially in healthy subjects. The aim of this study is to assess H. pylori infections and the associated risk factors in Tripoli, North Lebanon. A cross-sectional study was conducted on 300 healthy Lebanese volunteers, including both children and adults. The H. pylori stool antigens were detected using the Premier Platinum HpSA test. The socio-demographic data, lifestyle characteristics, and gastrointestinal characteristics of all participants were analyzed. Out of the 300 tested volunteer subjects, 31% were found to be positive for H. pylori. A multivariate binary logistic regression analysis for factors associated with H. pylori infection revealed a significant association between H. pylori infection and gastrointestinal disturbances, the crowding index, and occupation. A significant statistical correlation was found between sheesha smoking (p = 0.001) and H. pylori infection. These findings highlight the need for the development of preventive approaches and strategic indications for the appropriate treatment of H. pylori infections in Tripoli, North Lebanon.

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Tabaru, Ali, Metin Gorguner, Metin Akgun, Mehmet Meral, and Ali Sahin. "Helicobacter Pylori Infections in Chronic Obstructive Pulmonary Disease." Eurasian Journal of Medicine 44, no. 3 (December 1, 2012): 144–48. http://dx.doi.org/10.5152/eajm.2012.34.

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Go, Mae F. "Pathogenesis and Host Response in Helicobacter pylori Infections." Gastroenterology 115, no. 4 (October 1998): 1031. http://dx.doi.org/10.1016/s0016-5085(98)70288-4.

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Gościniak, Grażyna. "IgG and IgA Antibodies in Helicobacter pylori Infections." Zentralblatt für Bakteriologie 286, no. 4 (November 1997): 494–502. http://dx.doi.org/10.1016/s0934-8840(97)80052-7.

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Journal articles on the topic 'Infections à Helicobacter'

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