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Academic literature on the topic 'Inferno 2'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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Journal articles on the topic "Inferno 2"

1

Valenti, Michael. "Tracking Africa’s Inferno." Mechanical Engineering 122, no. 12 (December 1, 2000): 66–70. http://dx.doi.org/10.1115/1.2000-dec-6.

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This article focuses on instruments aboard an orbiting satellite and high-flying aircraft study grass fires that straddle a continent. NASA designed its $1.3 billion Terra to be the flagship in a new series of Earth-observing satellites that will study phenomena affecting the climate. The instruments carried by Terra that were most active during the Safari 2000 field experiment were Moderate-Resolution Imaging Spectro-Radiometer (MODIS), Multi-Angle Imaging Spectro-Radiometer (MISR), and Measurements of Pollution in the Troposphere (MOPITT). MOPITT accomplishes its mission by using gas correlation spectroscopy to measure rising and reflected infrared radiance in three absorption bands of carbon monoxide and methane. The Terra’s Safari 2000 observations were augmented by measurements taken by instruments aboard several aircraft, including the high-altitude Lockheed-Martin ER-2 that NASA flew from Pietersburg, South Africa, as part of the African field experiment. The South African Weather Bureau contributed two Aerocommander 690A aircraft to Safari 2000. One of the twin-engine, turboprop planes was used for aerosol research, while the other one helped validate the carbon monoxide measurements obtained by MOPITT.

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2

Rodríguez Mega, Emiliano. "The battle to rebuild centuries of science after an epic inferno." Nature 571, no. 7765 (July 2019): 312–15. http://dx.doi.org/10.1038/d41586-019-02141-2.

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3

Kurgan, Marina G. "The Images of Dante’s Inferno in Fyodor Dostoevsky’s The House of the Dead." Imagologiya i komparativistika, no. 15 (2021): 31–52. http://dx.doi.org/10.17223/24099554/15/2.

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The House of the Dead was repeatedly compared with the first part of Dante’s The Divine Comedy even in F.M. Dostoevsky’s lifetime. However, his contemporaries usually focused on general analogies, while later scholars paid more attention to the narrative features or individual reminiscences. This research studies the main aspects of the artistic structure of the Dante code, constructing the space of Hell in Dostoevsky’s novel. 1. The organization of space. Alexander Petrovich Goryanchikov, the narrator in The House of the Dead, recreates a three-dimensional image that resembles a gradually narrowing funnel: from a bird’s-eye view, where the prison is seen in its entirety, the focus slowly descends, passing to smaller objects, and finally reaching the “three boards”, which limit Goryanchikov’s personal space. The same principle is employed to construct the space of Hell in Dante’s poem. In The House of the Dead, there is another significant indication of the spatial affinity of Dante’s hell and Dostoevsky’s katorga – active imagery associated with cobwebs and spiders. In the centre of the system of images associated with the designated semantic network is the parade- major, the head of the fortress and the owner of the inmate web. 2. The character system as an element constituting the space of Hell. The character system of The House of the Dead follows the compositional principle of Divine Comedy, where sinners are located in different circles in accordance with their main passion. There are three circles in the prison: the first is formal, according to the court decision; the second is informal, internal, formed by crafts and occupations; the third represents Goryanchikov’s perspective as an exponent of human and humane judgment, which distinguishes another person’s moral state. 3. Torment. The House of the Dead demonstrate a hierarchy in describing the tortures, while freedom becomes a fundamental category to embody the most important motif of physical and moral torment connecting Dostoevsky’s novel with Dante’s experience. The bodily torment ceases to be only the torment of the body to become a pain of the soul, comparable to physical torment, so the soul suffers and burns. Hell as a moral topos was the key for Dostoevsky. In The House of the Dead, he chooses the same way as Dante in The Divine Comedy: vivid corporeality conveys an esoteric metaphor of moral suffering and deep inner movements of the soul.

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Rottenburg, Richard. "Das Inferno am Gazellenfluss: Ein afrikanisches Problem oder ein „schwarzes Loch“ der Weltgesellschaft?" Leviathan 30, no. 1 (March 2002): 3–33. http://dx.doi.org/10.1007/s11578-002-0009-2.

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Gama, Maria Gabriela. "Quando o Inferno desce à Terra: a gestão de crises e a sua problemática." Comunicação e Sociedade 2 (January 28, 2000): 535–42. http://dx.doi.org/10.17231/comsoc.2(2000).1419.

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Quando uma situação de crise ocorre na empresa, resultante de falhas que lhe são directa ou indirectamente imputáveis, a sua imagem é colocada em causa. Isto obriga a tomadas de posição acertadas e atempadas. Tudo é extrapolado para o exterior e a opinião pública irá ajuizar o modo como a empresa soube ultrapassar a situação crítica.Negar a existência de uma situação de crise quando esta ainda nao é visível pode acarretar consequências nefastas que transpõem largamente as fronteiras da empresa.Perante um cenário de crise, os órgaos de comunicação social procuram saber o que ocorreu e como está a evoluir toda a situação. O silêncio da empresa face aos órgãos de comunicação social vai criar nestes a necessidade de recorrer a fontes que, na maior parte das vezes, não possuem uma informação rigorosa sobre o que realmente está a ocorrer. Daí que a problemática das fontes seja também um assunto a abordar nesta comunicação.Todas estas crises têm as suas características próprias que exigem por parte daempresa o uso de todas as suas potencialidades e com serios constrangimentos de tempo.

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Rogério Heck Dorneles, Marcos. "Tecido narrativo em O inferno é aqui mesmo, de Luiz Vilela." REVISTA DO CENTRO DE ESTUDOS DA LINGUAGEM DA FUNDAÇÃO UNIVERSIDADE FEDERAL DE RONDÔNIA 4, no. 2 (2017): 49–65. http://dx.doi.org/10.47209/2594-4916.v.4.n.2.p.49-65.

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Konevets, S. N. "Svidrigailov’s Nightmares and the Inferno of V. Nabokov’s Hero (on the Transformation of One Plot)." Izvestiya of Saratov University. New Series. Series: Philology. Journalism 17, no. 2 (2017): 188–90. http://dx.doi.org/10.18500/1817-7115-2017-17-2-188-190.

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Larbie, Christopher, Benjamin O. Emikpe, Ademola A. Oyagbemi, Theophilus A. Jarikre, and Clement O. Adjei. "Acalypha wilkesiana ‘Inferno’ Is Nephroprotective Against Gentamicin and Cisplatin: Biochemical, Histological and Immunohistochemical Evidence." Iranian Journal of Toxicology 14, no. 4 (October 1, 2020): 201–14. http://dx.doi.org/10.32598/ijt.14.4.658.1.

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Background: Kidneys exposure to toxins can cause injuries, leading to their functional impairments. Traditionally, plants have been used for the treatment of renal disorders and numerous medicinal plants have been tested for their nephroprotective effects, in such cases as gentamicin (GM) and cisplatin (Cisp)-induced nephrotoxicity. This study assessed the ability of Acalypha wilkesiana’s extract to counteract its toxic effect based on the biochemical, histological and proinflammatory cytokines components in rats. Methods: Thirty-six male Wistar rats were randomly divided into nine groups (n=4 each) and administered the following treatments: a) normal control (1 mL/kg body weight normal saline from days 1-10); b) nephrotoxin (GM 120 mg/kg, days 2-7; or Cisp 7 mg/kg on day 3); c) standard drug (120 mg/kg Silymarin plus GM or Cisp, days 1-10); and, d) extract groups (100 or 250 mg/kg, days 1-10 plus GM). Blood samples were collected and subjected to hematological and biochemical evaluations while kidney tissue samples were examined for histopathological alterations, pro- and antioxidants, and expression of pro-inflammatory cytokines. Results: Treatment of the rats pre-exposed to GM or Cisp with the extract decreased the serum creatinine, urea and MDA levels. The GST and GPx levels were also restored in rats. Glomerular atrophy with tubular epithelial necrosis induced by either nephrotoxin was restored to near normal. The expression of COX-2 following the administration of either nephrotoxin was reversed after treatment with the extract. Conclusion: The A. wilkesiana extract exhibited significant nephroprotective property, which could potentially be regarded as a promising alternative to the management of renal diseases.

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Rocha, Bruno De Carvalho, and Marcio Cappelli Aló Lopes. "No princípio era o rap: a construção do mito em 'Sobrevivendo no Inferno', de Racionais Mc's." Estudos de Religião 34, no. 3 (December 18, 2020): 153–76. http://dx.doi.org/10.15603/2176-1078/er.v34n3p153-176.

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Neste artigo abordaremos alguns aspectos referentes ao mito e ao seu desenvolvimento em Sobrevivendo no inferno, dos Racionais Mc’s. Primeiramente, procuraremos discernir a trajetória do mito no rap brasileiro a partir de três blocos históricos: (1) até os anos 1989, (2) 1990-1999 e (3) de 2000 em diante. A partir da concepção do rap enquanto literatura oral urbana, tentaremos esclarecer a relação entre do mito e da experiência religiosa com a obra em questão. Em seguida, buscaremos descrever como se dá a construção de uma cosmogonia periférica através da faixa “Gênesis”, e apresentaremos uma proposta de leitura metafórica do mito em alguns trechos da faixa “Capítulo 4 versículo 3”, a fim de encontrar um caminho de acesso ao conteúdo poético do texto.

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Winchester, Chevelle, and Alan Hirsch. "121 Oviposit Dysgeusia; Head Trauma Induced Chemosensory Noisome Egg Dysgeusia: The Miasma of Dante’s Inferno-When Eggs Become Rotten." CNS Spectrums 25, no. 2 (April 2020): 278–79. http://dx.doi.org/10.1017/s1092852920000395.

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Introduction:Post-traumatic dysgeusia with conversion of the taste of eggs rotten eggs has not heretofore been described.Method:Case Report: A 60 year old right handed female 6 months prior to presentation sustained head trauma. Three days later she noted reduced taste and smell dysgeusia to eggs. Eggs tasted distorted, like rotten eggs. Raw egg whites had no smell or taste. Cooked egg whites had faint sulfur smell for 2-3 seconds and the taste of sulfur. Yolk of soft-boiled eggs, had no smell or taste. The white had no smell but an unbearable sulfur taste. Raw eggs had no smell. The yolk of hardboiled eggs had no smell and taste, the whites smelled and tasted like sulfur. Sunny side up eggs with yolk and white segregated had no smell but tasted, as they should. Sunny side up eggs with yolk and white mixed together has no smell but strong sulfur taste. Scrambled eggs had no smell but mild sulfur taste, which changed over time to a rotten egg smell and taste. With nose clips, scrambled eggs had 0/10 taste, without the nose clips the smell of sulfur was 3/10.Results:Olfaction: Normosmia to threshold and Retronasal Smell Index: 2 (abnormal): Gustatation : Normogeusia to all. Mild hypogeusia to sodium chloride. MRI: Multiple foci of periventricular and deep white matter demyelization.Discussion:Rotten egg smell maybe mediated through retro-nasal pathways, since nasal obstruction eliminated the rotten egg taste. Eggs can possibly be developed as a home device to assess chemosensory function.

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Dissertations / Theses on the topic "Inferno 2"

1

Ngan, Alfonso Hing-wan. "The temperature dependence of yield strength in L1 [inferior] 2 compounds." Thesis, University of Birmingham, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.658066.

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Glosenger, Jeremiah J. "Preliminary Comparison of Missed Blocks with 4% Articaine and 2% Lidocaine both with 1:100,000 epinephrine on Inferior Alveolar Nerve Block Injections." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1305927125.

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Lammers, Emily. "ANESTHETIC EFFICACY OF 3% MEPIVACAINE PLUS 2% LIDOCAINE WITH 1:100,000 EPINEPHRINE FOR INFERIOR ALVEOLAR NERVE BLOCKS." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1374854890.

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Cook, Olivia B. DMD. "Anesthetic Efficacy Of 4% Prilocaine Plus 2% Lidocaine With 1:100,000 Epinephrine For Inferior Alveolar Nerve Blocks." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu149945067803552.

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Hatakeyama, Márcia [UNESP]. "Expressão de HER-1 e HER-2 totais e fosforilados em queilite actínica e carcinoma epidermóide de lábio inferior." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/104568.

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Made available in DSpace on 2014-06-11T19:33:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-06-30Bitstream added on 2014-06-13T21:06:02Z : No. of bitstreams: 1 hatakeyama_m_dr_sjc.pdf: 755363 bytes, checksum: 572c154cdca893a035a5408346a4fcd4 (MD5)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
A queilite actínica (QA) é uma lesão multifocal que acomete o vermelhão do lábio com potencial de malignização para carcinoma epidermóide (CE). O receptor para o fator de crescimento epidermal (EGFR) é membro da família dos receptores tirosina quinase que participa da transformação e progressão da neoplasia maligna. O objetivo desta pesquisa foi verificar a expressão de HER-1 e HER-2 totais e fosforilados e possíveis correlações das expressões destas proteínas com lesões de QA e CE de lábio inferior por imunoistoquímica. Foram um estudo de 50 casos de QA, 50 casos de CE e 14 de Controle. Expressão das proteínas foi baseado num escore. Os dados obtidos foram analisados pelo teste de Kruskal-Wallis e como análise post-hoc o teste de Mann-Whitney com correção de Bonferroni e, correlação de Spearman. O nível de significância escolhido foi o valor convencional de 5%. A análise da comparação foi estatisticamente significativa na membrana do pHER-2, grupos Controle x QA e QA x CE; no citoplasma do HER-1, grupos Controle x QA, do pHER-1, grupos Controle x QA e Controle x CE, do pHER- 2, grupos Controle x QA e Controle x CE; no núcleo do pHER-1, grupos Controle x QA, do HER-2, Controle x QA e Controle x CE (p<0,05). O estudo da correlação foi estatisticamente significativa na membrana do HER-1 x pHER-2 no grupo QA, HER-1 x HER-2, HER-1 x pHER-1, HER-2 x pHER-1 no grupo CE; no citoplasma entre HER-1 x HER-2 no grupo QA, HER-1 x HER-2 no grupo CE; no núcleo entre HER-2 x pHER-1 no grupo Controle (p<0,05). Estes dados sugerem que a maior marcação no grupo Controle poderia ser decorrente da variedade de lesões benignas que compõem esse grupo e que poderiam apresentar proliferação aumentada. Localização nuclear poderia estar relacionada não apenas como iniciadores das cascatas intracelulares, mas também como fatores de transcrição...
Actinic cheilitis (AC) is a multifocal lesion that occurs in lip vermillion with potential of malignant transformation to epidermoid carcinoma (EC). Epidermal growth factor receptor (EGFR) is a member of tyrosine kinase family, involved in transformation and progression of malignant tumour. The aim of this study was to analyse the expression of total and phosphorylated HER-1 and HER-2 and correlate expression of these proteins with lesions of AC and CE in lower lip by immunohistochemistry. It was a study of 50 cases of AC, 50 of EC and 14 of Control. Proteins expressions were based on a score. Obtained datas were analysed by Kruskal-Wallis test and post-hoc analysis with Mann-Whitney test with Bonferroni correction and, Spearman correlation. The level of significance was 5%. The analysis of the comparison was statistically significant in membrane of pHER-2, group Control x AC and AC x EC; in cytoplasma of HER-1, Control x AC, pHER-1,Control x AC and Control x EC, pHER-2, Control x AC and Control x EC; in nucleus of pHER-1, Control x AC, HER-2, Control x AC and Control x EC (p<0,05). The study of the correlation was statistically significant in membrane of HER-1 x pHER-2 expression in AC, HER-1 x HER-2, HER-1 x pHER-1and HER-2 x pHER-1 in EC; in cytoplasma, HER-1 x HER-2 in AC, HER-1 x HER-2 in EC; in nucleus, HER-2 x pHER-1 in Control (p<0,05). Our findings suggested that a higher expression in Control group could be due to a composition of this group by a variety of benign lesions that could present increased proliferation. Nuclear localization could be related not only with the action of intracellular cascade beginners, but also to action as transcription factors. Phosphorylation of HER-1 and HER-2 by MAPK pathway can be independent of total level of proteins in AC and EC lip lesions, because phosphorylation might be increased indirectly by UV radiation in a ligand independent way... (Complete abstract click electronic access below)

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Hatakeyama, Márcia. "Expressão de HER-1 e HER-2 totais e fosforilados em queilite actínica e carcinoma epidermóide de lábio inferior /." São José dos Campos : [s.n.], 2010. http://hdl.handle.net/11449/104568.

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Orientador: Ana Sueli Rodrigues Cavalcante
Banca: Adriana Aigotti H. Brandão
Banca: Ana Lia Anbinder
Banca: Marília T. Martins
Banca: Fábio L. Forti
Resumo: A queilite actínica (QA) é uma lesão multifocal que acomete o vermelhão do lábio com potencial de malignização para carcinoma epidermóide (CE). O receptor para o fator de crescimento epidermal (EGFR) é membro da família dos receptores tirosina quinase que participa da transformação e progressão da neoplasia maligna. O objetivo desta pesquisa foi verificar a expressão de HER-1 e HER-2 totais e fosforilados e possíveis correlações das expressões destas proteínas com lesões de QA e CE de lábio inferior por imunoistoquímica. Foram um estudo de 50 casos de QA, 50 casos de CE e 14 de Controle. Expressão das proteínas foi baseado num escore. Os dados obtidos foram analisados pelo teste de Kruskal-Wallis e como análise post-hoc o teste de Mann-Whitney com correção de Bonferroni e, correlação de Spearman. O nível de significância escolhido foi o valor convencional de 5%. A análise da comparação foi estatisticamente significativa na membrana do pHER-2, grupos Controle x QA e QA x CE; no citoplasma do HER-1, grupos Controle x QA, do pHER-1, grupos Controle x QA e Controle x CE, do pHER- 2, grupos Controle x QA e Controle x CE; no núcleo do pHER-1, grupos Controle x QA, do HER-2, Controle x QA e Controle x CE (p<0,05). O estudo da correlação foi estatisticamente significativa na membrana do HER-1 x pHER-2 no grupo QA, HER-1 x HER-2, HER-1 x pHER-1, HER-2 x pHER-1 no grupo CE; no citoplasma entre HER-1 x HER-2 no grupo QA, HER-1 x HER-2 no grupo CE; no núcleo entre HER-2 x pHER-1 no grupo Controle (p<0,05). Estes dados sugerem que a maior marcação no grupo Controle poderia ser decorrente da variedade de lesões benignas que compõem esse grupo e que poderiam apresentar proliferação aumentada. Localização nuclear poderia estar relacionada não apenas como iniciadores das cascatas intracelulares, mas também como fatores de transcrição... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Actinic cheilitis (AC) is a multifocal lesion that occurs in lip vermillion with potential of malignant transformation to epidermoid carcinoma (EC). Epidermal growth factor receptor (EGFR) is a member of tyrosine kinase family, involved in transformation and progression of malignant tumour. The aim of this study was to analyse the expression of total and phosphorylated HER-1 and HER-2 and correlate expression of these proteins with lesions of AC and CE in lower lip by immunohistochemistry. It was a study of 50 cases of AC, 50 of EC and 14 of Control. Proteins expressions were based on a score. Obtained datas were analysed by Kruskal-Wallis test and post-hoc analysis with Mann-Whitney test with Bonferroni correction and, Spearman correlation. The level of significance was 5%. The analysis of the comparison was statistically significant in membrane of pHER-2, group Control x AC and AC x EC; in cytoplasma of HER-1, Control x AC, pHER-1,Control x AC and Control x EC, pHER-2, Control x AC and Control x EC; in nucleus of pHER-1, Control x AC, HER-2, Control x AC and Control x EC (p<0,05). The study of the correlation was statistically significant in membrane of HER-1 x pHER-2 expression in AC, HER-1 x HER-2, HER-1 x pHER-1and HER-2 x pHER-1 in EC; in cytoplasma, HER-1 x HER-2 in AC, HER-1 x HER-2 in EC; in nucleus, HER-2 x pHER-1 in Control (p<0,05). Our findings suggested that a higher expression in Control group could be due to a composition of this group by a variety of benign lesions that could present increased proliferation. Nuclear localization could be related not only with the action of intracellular cascade beginners, but also to action as transcription factors. Phosphorylation of HER-1 and HER-2 by MAPK pathway can be independent of total level of proteins in AC and EC lip lesions, because phosphorylation might be increased indirectly by UV radiation in a ligand independent way... (Complete abstract click electronic access below)
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Schneider, Paula Sudeeda [Verfasser]. "Vergleich der anästhetischen Wirkung von Lidocain 2% und Articain 2% zur Leitungsanästhesie des Nervus alveolaris inferior bei kleineren zahnärztlich-chirurgischen Eingriffen - randomisierte prospektive klinische Studie / Paula Sudeeda Schneider." Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2020. http://d-nb.info/1224810309/34.

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CAMPOS, Patrícia Isabel Figueiredo. "Characterization of T follicular helper (Tfh) cells and B cell isotype switching induced by type 1 and type 2 adjuvants." Master's thesis, Instituto de Higiene e Medicina Tropical, 2016. http://hdl.handle.net/10362/20059.

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A principal função dos linfócitos T CD4+ é fornecer apoio a outras células no sentido de gerar uma resposta imunitária eficiente. As interações entre as células T e B são essenciais para a produção de respostas humorais, sendo que foi recentemente demonstrado que as células T foliculares auxiliares (Tfh) desempenham um papel crucial neste processo. Caracteristicamente, expressam o fator de transcrição Bcl-6, o recetor de quimiocinas CXCR5 e o marcador de superfície PD-1. A expressão destes marcadores é única e fundamental para que estas células possam aceder ao folículo de células B, onde orientam as reações no centro germinativo (GC), levando à consequente mudança de isótipo, maturação da afinidade, produção de anticorpos de alta afinidade e células B de memória. Neste projeto, foram testadas duas hipóteses opostas no sentido de caracterizar fenotipicamente as células Tfh. Propomos investigar se estas são especializadas no fornecimento de auxílio do tipo Th1 ou Th2, que designamos de células hipotéticas "Tfh1" e "Tfh2" (Hipótese 1) ou se são uma subpopulação genérica que responde igualmente na presença de diferentes antigénios, células Tfh (Hipótese 2). Deste modo, murganhos C57BL/6J e Balb/c foram imunizados na almofada plantar da pata traseira, utilizando proteína Ovalbumin (OVA) combinada com diferentes tipos de adjuvantes: CpG ODNs isoladamente e em combinação com TiterMax® Gold (TMX), Sigma Adjuvant System (SAS) e Montanide ISA 720 VG, testados como adjuvantes tipo 1, e por sua vez Incomplete Freund’s Adjuvant (IFA) e Alum experimentados como adjuvantes do tipo 2. A técnica de ELISA permitiu determinar no soro dos murganhos o tipo de resposta gerada, através da medição de imunoglobulinas específicas para OVA (IgG2a para Th1, IgG1 e IgE total para Th2). CpG ODNs e IFA foram considerados como os adjuvantes mais apropriados para induzir respostas Th1 e Th2, respetivamente. Células T que reconhecem especificamente OVA foram colhidas de murganhos OT-II Rag-/- e DO11.10 Rag-/- e transferidas para murganhos congénicos. De seguida, procedeu-se à imunização tal como descrito acima. Os nódulos linfáticos drenantes foram recolhidos no pico da reação do centro germinativo (11 dias após imunização), assim como as células Tfh específicas para OVA (CD4+CD44+ CXCR5+PD-1+ Thy1.2+Vβ5+Vα2+/DO11.10+) e as células T auxiliares ativadas específicas para OVA (CD4+CD44+CXCR5-PD-1- Thy1.2+Vβ5+Vα2+/DO11.10+). A caracterização molecular destas populações de células T está a ser analisada através da sequenciação dos seus transcritos pela técnica de RNA-sequencing. Além disso, a expressão de marcadores de Th1 e Th2 em células Tfh foi analisada através de citometria de fluxo e Reação em Cadeia da Polimerase quantitativa por Transcrição Reversa (RT-qPCR). Neste estudo, foi demonstrado que as células Tfh co-expressam Bcl-6 e T-bet e também produzem IFN-γ, quando sensibilizadas com OVA-CpG ODNs, características concordantes com os marcadores fenotípicos de uma célula Tfh e célula Th1. A expressão de Gata-3 (marcador Th2) só foi detetada sob estimulação IFA-OVA, embora em níveis mais baixos do que as determinadas para T-bet.
The major function of CD4+ T cells is to provide help to other lymphocytes to mount an efficient immune response. T and B cell interactions are essential for humoral responses and it was recently shown that T follicular helper (Tfh) cells play a crucial role in this process. They characteristically express the transcription factor Bcl-6, chemokine receptor CXCR5 and PD-1. These markers are unique as their expression is pivotal to acquire access to the B cell follicle and drive germinal centre (GC) reactions, leading to isotype switching, affinity maturation, and production of high affinity antibodies and memory B cells. In this project, two competing hypothesis investigating the phenotype of Tfh cells were tested. We propose to dissect whether Tfh cells are specialized in providing Th1 or Th2 help, which we call putative “Tfh1” and “Tfh2” cells (hypothesis 1), or if they are a more generic Th subset that responds equally in the presence of different antigens, which we designate as Tfh cells (hypothesis 2). Therefore, we immunized C57BL/6J and Balb/c mice in the footpad using Ovalbumin (OVA) protein combined with different adjuvant types: CpG ODNs only and combined with TiterMax® Gold (TMX), Sigma Adjuvant System (SAS) and Montanide ISA 720 VG, as type 1 adjuvant, and Incomplete Freund’s Adjuvant (IFA) and Alum as type 2 adjuvants. Using ELISA assays to determine the type of response generated by measuring serum immunoglobulins of distinct clones (OVA-specific IgG2a for Th1 and OVA-specific IgG1 and total IgE for Th2), we considered CpG ODNs and IFA as the most appropriate adjuvants to induce Th1 and Th2 responses, respectively. OVA-specific cells were transferred from OT-II Rag-/- and DO11.10 Rag-/- mice into congenic mice subsequent to immunization as described above. Draining LNs were collected at the peak of the GC reaction (day 11 post-immunization) and OVA-specific Tfh cells (CD4+ CD44+ CXCR5+PD-1+ Thy1.2+Vβ5+Vα2+/DO11.10+) and OVA-specific activated-Th cells (CD4+ CD44+ CXCR5-PD-1- Thy1.2+Vβ5+Vα2+/DO11.10+) were sorted. The molecular signature of these T cell populations is being analysed via RNA-Sequencing. Moreover, the expression of Th1 and Th2 markers on Tfh cells was investigated via flow cytometry and Reverse Transcription quantitative Polymerase Chain Reaction (RT-qPCR). In this study, it could be shown that Tfh cells of mice immunized with OVA-CpG ODNs co-expressed Bcl-6 and T-bet and also produced IFN-γ, both concordant features with the phenotypic markers of a Tfh cell and of a Th1 cell. As for the expression of Gata-3, it has only been detected in mice under IFA-OVA stimulation, even though at levels lower than the ones determined for T-bet.

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ALMEIDA, Débora Joana Rodrigues Lopes de. "Papel das regiões C2-V3-C3 na indução de anticorpos neutralizantes anti-VIH-2." Master's thesis, Instituto de Higiene e Medicina Tropical, 2016. http://hdl.handle.net/10362/19070.

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A Síndrome da Imunodeficiência Adquirida (SIDA) é uma doença grave que se caracteriza pela destruição ou pelo desaparecimento de reações imunitárias do organismo, que permitem o surgimento de infeções oportunistas que podem levar à morte. O agente etiológico responsável pela SIDA é o Vírus da Imunodeficiência Humana (VIH) e existem dois tipos: o tipo 1 (VIH-1) e o tipo 2 (VIH-2). Quando comparados, o VIH-2 tem uma taxa de transmissão menor e uma progressão da doença mais lenta, o que faz com que os indivíduos infetados tenham um melhor prognóstico. Um dos fatores importantes nesta resposta imunológica é a presença de anticorpos neutralizantes (nAbs) e a pouca capacidade do VIH-2 na evasão a esta resposta. Os nAbs têm a capacidade de inibir a entrada do vírus nas células, através da sua ligação a regiões específicas presentes nas glicoproteínas do invólucro viral. A região V3 do domínio C2V3C3 existente na glicoproteína de superfície do invólucro do VIH-2 é um dos alvos preferenciais dos nAbs. No entanto, desconhece-se ainda de que forma as regiões adjacentes, C2 e C3, contribuem para uma resposta neutralizante. Este estudo teve como objetivos caracterizar o impacto das regiões C2, V3 e C3 na resposta de anticorpos não neutralizantes e neutralizantes na infeção por VIH-2. Para isso, recorreu-se à produção de péptidos recombinantes correspondentes a cada uma das regiões referidas anteriormente através da transformação e crescimento de bactérias competentes E. coli TOP10 com plasmídios clonados com fragmentos de ADN das regiões C2, V3 e C3, respetivamente. Após a sua produção, os péptidos recombinantes foram purificados por Fast Protein Liquid Chromatography (FPLC) e utilizados como antigénios em imunoensaios (ELISA), para estudar a reatividade de cada um dos péptidos com um painel de soros positivos para VIH-2. Observou-se maior serorreatividade contra o péptido recombinante V3 (prV3), seguido do prC3 e do prC2. Foram feitas correlações entre os valores obtidos neste estudo e valores obtidos em estudo realizado anteriormente sobre a potência da neutralização dos anticorpos (IC50) presentes em alguns dos soros utilizados. Verificou-se que não havia associação entre a neutralização e a serorreatividade contra cada região, o que pode indicar que os anticorpos neutralizantes produzidos por indivíduos infetados pelo VIH-2 não são específicos para nenhuma das respetivas regiões. No entanto, o número elevado de casos de serorreatividade pode ser indicativo de que as 3 regiões em conjunto possam ser responsáveis pela indução de anticorpos neutralizantes específicos para o domínio C2V3C3, tal como já foi observado anteriormente.
Acquired Immunodeficiency Syndrome (AIDS) is a severe disease characterized by destruction or disappearance of the immune reactions of the organism, wich enables the appearance of opportunistic infections that can lead to death. The etiological agent responsible for AIDS is the Human Immunodeficiency Virus (HIV) and there are two types: type 1 (HIV-1) and type (HIV-2). When compared, HIV-2 has a lower transmission rate and a slower progression of the disease, which causes the infected individuals to have a better prognosis. One of the important factors in this immune response is the presence of neutralizing antibodies (nAbs) and the limited capacity of HIV-2 to escape. The nAbs have the ability to inhibit viral entry into cells, through its binding to specific regions present in the viral envelope glycoproteins. The V3 region existing in C2V3C3 domain present on surface glycoprotein of HIV-2 envelope is the main target of nAbs. However, it is still unknown how the adjacent regions, C2 and C3, contribute to a neutralizing response. This study aimed to characterize the impact of the regions C2, V3 and C3 in non-neutralizing and neutralizing antibody response in infection by HIV-2. Therefore, recombinant peptides were produced corresponding to each of the regions mentioned above by transformation and growth of competent bacteria E. coli TOP10 with plasmids cloned with DNA fragments of the C2, V3 and C3 regions, respectively. After their production, the recombinant peptides were purified by Fast Protein Liquid Chromatography (FPLC) and used as antigens in imunoassays (ELISA) to study the reactivity of each peptide with a panel of positive sera for HIV-2. It was observed a higher serorreactivity against recombinant peptide V3 (prV3), followed by prC3 and prC2. Correlations were made between the values obtained in this study and values obtained in a previous study about the potency of neutralizing antibodies (IC50) present in some of the used sera. It was found that there was no association between the neutralization and serorreactivity against each region, which may indicate that neutralizing antibodies produced by individuals infected with HIV-2 are not specific for any of the respective regions. However, the large number of cases of serorreactivity may be indicative that the three regions together may be responsible for the induction of neutralizing antibodies specific for C2V3C3 domain, as noted earlier.

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Goulão, Maria Carolina Barata. "Estudo da adesão de mães de crianças até aos 2 anos de idade às medidas de prevenção da infeção congénita por Citomegalovírus." Master's thesis, Universidade da Beira Interior, 2013. http://hdl.handle.net/10400.6/1639.

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A presente dissertação é composta por três capítulos descritivos da minha experiência profissionalizante em farmácia hospitalar e comunitária e do meu estudo de investigação. O primeiro capítulo relata o meu estágio em farmácia hospitalar que foi realizado no Hospital Sousa Martins, na Guarda. Com este capítulo pretendo descrever os conhecimentos que adquiri e as atividades em que colaborei durante o estágio, que me permitiram perceber quais as valências e funções desempenhadas pelos farmacêuticos no dia-a-dia de trabalho em hospital O segundo capítulo descreve o meu estágio em farmácia comunitária, realizado na Farmácia Taborda, no Fundão. Durante este período de estágio tive a oportunidade de conhecer melhor o papel do farmacêutico junto da comunidade e aperceber-me das funções e responsabilidades dos farmacêuticos na promoção da Saúde Pública e da racionalização do uso de medicamentos. O terceiro capítulo diz respeito à investigação realizada no âmbito do estudo da adesão de mães de crianças até dois anos de idade às medidas de prevenção da infeção congénita por Citomegalovírus (CMV). O Citomegalovírus é o principal agente de infeção congénita nos países desenvolvidos afetando atualmente cerca de 0,2%-2,2% de todos os recém-nascidos. Devido ao espectro das consequências associadas à infeção congénita por CMV, este tem-se tornado, atualmente, uma das maiores preocupações de Saúde Pública. Com estudos de várias opções de prevenção e tratamento da infeção congénita por CMV ainda a decorrer, a adoção de medidas de higiene parece ser, por enquanto, a única forma de prevenção da infeção citomegálica durante a gravidez. Com o objetivo de determinar a adesão das mulheres em idade fértil a essas medidas de higiene foi realizado um inquérito a 570 mães de crianças até 2 anos de idade questionando acerca da sua recetividade para a adoção das medidas propostas, sabendo que tais medidas poderiam prevenir possíveis malformações num futuro recém-nascido. Das medidas propostas a maioria das mulheres (61,5%) considerou que dificilmente deixaria de mudar as fraldas ao seu filho, mas certamente lavaria as mãos depois de mudar as fraldas (91,9%). 81,8% das mulheres inquiridas afirmaram que dificilmente deixariam de brincar com os seus filhos, mas 44,5% afirmou que certamente lavaria as mãos depois de manusear os brinquedos e 73,8% das inquiridas afirmou que deixaria de trocar colheres e escovas de dentes com a criança. Das medidas propostas a que se mostrou um perfil de respostas mais díspar foi a de deixar de dar beijos na boca e nariz dos seus filhos, com 38,7% das inquiridas a dizer que certamente o faria e 25,0% a afirmar que dificilmente praticaria esta medida de prevenção. Também no estudo da adesão às medidas de prevenção em mulheres cuja profissão exige contato direto com bebés e crianças em idade pré-escolar a adoção das medidas de higiene no local de trabalho foi bem aceite, com a maioria das mulheres a afirmar que certamente praticaria todas elas, com um perfil de adesão bastante semelhante às praticadas com os seus próprios filhos. Da análise dos resultados podemos concluir que se for explicado às futuras mães os riscos que correm a maioria delas está disposta a evitar o contacto com as secreções dos seus filhos, sendo a educação para a adoção destes comportamentos uma medida fácil de implementar e com resultados já comprovados em estudos internacionais, não só para prevenir a infeção congénita pelo CMV mas também para prevenir outras infeções transmissíveis pelo contacto com secreções.
This paper consists of three chapters which describe my internships in community and hospital pharmacy and my own research. The first chapter describes my internship in a hospital pharmacy that was performed in the Hospital Sousa Martins, in Guarda. In this chapter I would like to describe the knowledge I gained and the activities in which I participated during the internship, which allowed me to realize which functions are performed by pharmacists in a daily basis in a hospital. The second chapter describes my internship in a community pharmacy, held at Pharmacy Taborda, in Fundão. During this internship period I had the opportunity to learn more about the role of the pharmacist in the community and became conscious of the functions and responsibilities of pharmacists in public health promotion and rationalization of the use of medicines. The third chapter concerns the research carried out, to study how the mothers of children under two years of age comply with preventive measures of congenital Cytomegalovirus infection. Cytomegalovirus is the main agent of congenital infection in developed countries, affecting approximately 0,2%-2,2% of all newborns. Due to the spectrum of complications associated with congenital CMV infection, this has become one of the biggest concerns of public health. With studies of several options for prevention and treatment of congenital CMV infection still ongoing, the adoption of measures of hygiene seems to be, for now, the only way of preventing CMV infection during pregnancy. In order to determine how women in childbearing age follow these hygiene measures, a survey was conducted to 570 mothers of children up to 2 years of age. This survey seeks to understand how receptive they were about the adoption of the measures proposed, bearing in mind that such measures could prevent possible malformations in the newborn. Of the measures proposed, most women (61.5%) considered that they would hardly stop changing the diapers to their children, but surely would wash their hands after doing it (91.9%). 81,8% of the women surveyed stated that they wouldn't stop playing with their children, but 44,5% stated that they certainly would wash their hands after handling the toys. 73,8% of these women stated that they would stop using the same spoons and toothbrushes as their children. Of the proposed measures, one of the questions which had the most ambiguous and diverging answers, was the one which asks them if they would stop kissing their children on the mouth and nose. 38,7% of the surveyed women said that they certainly would. 25,0% stated that they would hardly practice this measure of prevention. Also in this study, as far as the women whose job requires direct contact with babies and pre-school children are concerned, the adoption of hygiene measures in the workplace was well accepted. Most women said that they would certainly follow them all, with results quite similar to those practiced with their own children. From the analysis of the results, we can conclude that if the risks of CMV congenital infection are explained to future mothers, most of them are willing to avoid contact with the secretions of their children And the education for the adoption of these measures, which not only prevents congenital infection by CMV, but also other infections transmitted by contact with secretions, is easy to implement, with results proven in international studies.

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Books on the topic "Inferno 2"

1

Jacoff, Rachel. Inferno II. Philadelphia: University of Pennsylvania Press, 1989.

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2-INFERNO-2: Aleksandr Bashirov, Tatʹ︠i︡ana Drubich : [kinos︠t︡senarii]. Moskva: AST, 2008.

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Feng, Yi. Microstructural assessment of high-T [inferior]C YBa [inferior]2 Cu [inferior]3 O [inferior] 7-Y and (Bi[inferior]2-X Pb[inferior]x)Sr [inferior]2 Ca [inferior]2 Cu[inferior]3 O[inferior]10 Superconductors. Birmingham: University of Birmingham, 1990.

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Zhang, Xu-jun. A study of the coercivity behaviour of Nd [inferior] 2 Fe [inferior] 14 B-type alloys via gas processing (O [inferior]2 and H [inferior] 2). Birmingham: University of Birmingham, 1991.

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Hollin, Cathryn A. The characterisation of electrical contacts on YBa [inferior] 2 Cu [inferior] 3 O [inferior] 7 [inferior] [minus] [inferior] x. Birmingham: University of Birmingham, 1991.

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Yeadon, Mark. Microstructures and properties of heteroepitaxial YBa[inferior]2 Cu[inferior]3 O[inferior]7-[delta]. Birmingham: University of Birmingham, 1995.

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Goodyear, Simon Wray. Characterisation of YBa[inferior 2]Cu[inferior 3]O[inferior 7] thin films and device structures. Birmingham: University of Birmingham, 1994.

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Shields, Trevor Charlesworth. An investigation of the Laves phase pseudobinary system CR (Fe[inferior]1-xNi[inferior]x)[inferior]2. Birmingham: University of Birmingham, 1989.

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Hill, Penelope Jane. Investigation of ternary alloys based on the Fe [inferior]3 Ga [inferior]2-X As [inferior] x system. Birmingham: University of Birmingham, 1990.

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Twin, Andrew J. The high temperature magnetic properties of YBa[inferior]2Cu[infer ior]3O[inferior]6[plus]y and Yba[inferior]2(Cu[inferior]1[minus]xF e[inferior]x)[inferior]3O[inferior]6[plus]y. Birmingham: University of Birmingham, 1991.

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Book chapters on the topic "Inferno 2"

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Heaney, Seamus. "Translation of Inferno, Canto 2." In Dante’s Modern Afterlife, 261–64. London: Palgrave Macmillan UK, 1998. http://dx.doi.org/10.1007/978-1-349-26975-4_16.

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Mendoza, John E. "Inferior Colliculi." In Encyclopedia of Clinical Neuropsychology, 1. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-56782-2_744-2.

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Loyola, S., L. W. J. Bosman, J. R. De Gruijl, M. T. G. De Jeu, M. Negrello, T. M. Hoogland, and C. I. De Zeeuw. "Inferior Olive: All Ins and Outs." In Handbook of the Cerebellum and Cerebellar Disorders, 1–56. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-97911-3_43-2.

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Kostadinov, Dimitar, Alexandre Mathy, and Beverley A. Clark. "Dynamics of the Inferior Olive Oscillator and Cerebellar Function." In Handbook of the Cerebellum and Cerebellar Disorders, 1–21. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-97911-3_44-2.

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Voogd, Jan, Yoshikazu Shinoda, Tom J. H. Ruigrok, and Izumi Sugihara. "Cerebellar Nuclei and the Inferior Olivary Nuclei: Organization and Connections." In Handbook of the Cerebellum and Cerebellar Disorders, 1–61. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-97911-3_19-2.

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Heil, Peter, and Henning Scheich. "Different Binaural Inputs Subdividing Isofrequency Planes in Chick Inferior Colliculus: Evidence from 2-Deoxyglucose." In Auditory Pathway, 185–90. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-1300-7_26.

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Del Maestro, Mattia, Sabino Luzzi, and Renato Galzio. "Microneurosurgical Management of Posterior Inferior Cerebellar Artery Aneurysms: Results of a Consecutive Series." In Acta Neurochirurgica Supplement, 33–38. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63453-7_5.

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AbstractAneurysms of the posterior inferior cerebellar artery (PICA) are uncommon. The complex anatomy of PICA and its intimate relationships with medulla, lower cranial nerves, and jugular tubercle makes the surgical treatment of these aneurysms fascinating. The reported is study aimed at a critical review of the overall results of a personal series of PICA aneurysms, treated by the senior author, R. Galzio. Demographics, charts, videos, outcome, and follow-up of a cohort of PICA aneurysms managed in the last 10 years were retrospectively analyzed, focusing only upon those treated with microneurosurgery. Twenty-five patients, harboring a single aneurysm, were operated on. Fifteen aneurysms were ruptured. Nineteen were proximal, all of these being been treated through a far-lateral approach. Trans-condylar or trans-tubercular variants were rarely necessary and however reserved to peculiar cases. Twenty-three aneurysms underwent direct treatment consisting of clip ligation. At 6-month follow-up, 60% of patients had a modified Rankin Score (mRS) of 0–2. Given the high anatomical variability of both PICA and patients’ bony anatomy, a case-by-case meticulous preoperative imaging evaluation is mandatory for the choice of the most suitable and tailored surgical corridor which, in turn, is pivotal to achieve the best outcome.

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Felber, Stephan, and Ali Daoun. "Posterior Inferior Cerebellar Artery Aneurysm: Subarachnoid Hemorrhage after a Minor Trauma, Fusiform Dissecting Aneurysm, Treatment with a p64 Flow Diverter." In The Aneurysm Casebook, 1–6. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-70267-4_10-2.

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Leutgeb, Lorenz, Georg Moser, and Florian Zuleger. "ATLAS: Automated Amortised Complexity Analysis of Self-adjusting Data Structures." In Computer Aided Verification, 99–122. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-81688-9_5.

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AbstractBeing able to argue about the performance of self-adjusting data structures such as splay trees has been a main objective, when Sleator and Tarjan introduced the notion of amortised complexity.Analysing these data structures requires sophisticated potential functions, which typically contain logarithmic expressions. Possibly for these reasons, and despite the recent progress in automated resource analysis, they have so far eluded automation. In this paper, we report on the first fully-automated amortised complexity analysis of self-adjusting data structures. Following earlier work, our analysis is based on potential function templates with unknown coefficients.We make the following contributions: 1) We encode the search for concrete potential function coefficients as an optimisation problem over a suitable constraint system. Our target function steers the search towards coefficients that minimise the inferred amortised complexity. 2) Automation is achieved by using a linear constraint system in conjunction with suitable lemmata schemes that encapsulate the required non-linear facts about the logarithm. We discuss our choices that achieve a scalable analysis. 3) We present our tool $$\mathsf {ATLAS}$$ ATLAS and report on experimental results for splay trees, splay heaps and pairing heaps. We completely automatically infer complexity estimates that match previous results (obtained by sophisticated pen-and-paper proofs), and in some cases even infer better complexity estimates than previously published.

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Hernández-Durán, Silvia, and Veit Rohde. "Posterior Inferior Cerebellar Artery Aneurysm: Microsurgical Clipping of a Ruptured Posterior Inferior Cerebellar Artery (PICA) Aneurysm Not Well Suited to Endovascular Treatment, Far-Lateral Transcondylar Approach to the Anterior Medullary Segment of the PICA, Complete Exclusion of the Aneurysm with Preservation of the Parent Artery." In The Aneurysm Casebook, 1–8. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-70267-4_124-2.

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Conference papers on the topic "Inferno 2"

1

Ellis, Fred V. "Inferior Material Failures." In ASME/JSME 2004 Pressure Vessels and Piping Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/pvp2004-2240.

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Three failures due to inferior material are discussed. In all cases, the specified material was 2-1/4 Cr-1 Mo and the installed material was carbon steel. A carbon steel girth weld in a hot reheat steam line failed after approximately 102,000 hours of service. The fracture was in the weld metal adjacent to the fusion interface. Creep rupture tests were performed using all weld metal and weldment specimens. The weldment life was approximately twice that of the all weld metal specimen, consistent with the effect of specimen size and oxidation on rupture life. The weldment fracture was in the weld metal adjacent to the fusion interface. The second failure was a main steam line drain failure. Based on safety considerations and as a corrective action, alloy analysis (positive material identification) was performed at three units on approximately 75 different high temperature drain lines. Inferior materials were found in straight pipes, elbows, and valves. The last series of failures were in the stub tubing at the reheat header installed by the OEM and in a superheat tube installed by the utility.

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Wallace, Byron C., Do Kook Choe, Laura Kertz, and Eugene Charniak. "Humans Require Context to Infer Ironic Intent (so Computers Probably do, too)." In Proceedings of the 52nd Annual Meeting of the Association for Computational Linguistics (Volume 2: Short Papers). Stroudsburg, PA, USA: Association for Computational Linguistics, 2014. http://dx.doi.org/10.3115/v1/p14-2084.

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Bansal, Mukesh, Mukesh Bansal, Manjunath Kustagi, Celine Lefebvre, Gabrielle Rieckhof, Luc Girard, David Merberg, et al. "Abstract LB-27: Dissecting signaling transduction network to infer master regulators of non small cell lung cancer." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-lb-27.

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Cassilly, Ryan T., Haley A. Bunting, Brian Jin, Christopher S. Ahmad, Louis U. Bigliani, William N. Levine, and Thomas R. Gardner. "Failure Properties of the Simian Inferior Glenohumeral Ligament." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53520.

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Several animal models of the shoulder are currently in use, including the rat, sheep and goat, as a means to model shoulder pathology[1]. Cynomolgus monkeys have served as nonhuman primate models in several studies including monkey models of menopause [2], reproductive support structures [3] and the knee joint[4]. Anatomical comparisons of simian and human shoulders have demonstrated that the simian shoulder is similar to that of the human in both musculature and bony structures[5]. A preliminary study concluded that there exists a high degree of similarity between the simian and human glenohumeral joint (GHJ)[6]. Biomechanical studies have been performed on the human IGHL to determine its tensile properties [7] yet there are few comparative studies of the biomechanical properties of the simian and human GHJ. The objective of this study was to determine the geometric and tensile properties of the simian IGHL as compared to those of the human IGHL.

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Studennikova, N. L., Z. V. Kotolovets, and R. G. Timofeev. "STUDY OF AGROBIOLOGICAL AND TECHNOLOGICAL FEATURES OF PERSPECTIVE CLONES OF GRAPES VARIETY MUSCAT ROSE." In STATE AND DEVELOPMENT PROSPECTS OF AGRIBUSINESS Volume 2. DSTU-Print, 2020. http://dx.doi.org/10.23947/interagro.2020.2.482-485.

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One of the promising varieties for the production of high-quality sparkling, dessert and liquor wines is the technical variety of pink muscat grapes. The aim of this work is to study the agrobiological and technological features of promising clones of the Pink Muscat variety. The object of study was two clones of the Pink Muscat variety - № 21-2-3 and № 53-10-2, growing on the clone test site (№ 509), the Gurzuf branch of the State Unitary Enterprise of the Republic of Kazakhstan PJSC Massandra on an area of 0.5 hectares. The article provides a statistical analysis of the quantitative characteristics of clones of the Muscat pink variety for 2018-2019, as well as the physicochemical and organoleptic characteristics of grapes and wine materials from clones of this variety of the 2019 crop. It was established that the fruiting coefficients (0.6- 0.65) in the studied clones are at the control level and are characterized as average. The mass of a bunch of clones exceeds the control by 1.4-2.15 times, reaching 322-494 g. The actual yield from the bush is 4.9-6.8 kg, exceeding the control by 2.13-2.96 times. According to the indicator, the shoot productivity in the wet mass of a bunch of 209.3-296.4 g /clone shoot is 1.68-2.38 times higher than the control. Wine materials made from clones of the Muscat pink grape varieties possess the amount of phenolic substances (within 506 mg /dm3 ) and the concentration of the reduced extract (23-25 g/dm3 ) at the control level, which gives grounds for further study of the selected clones in the technology of various types of wines . Tasting evaluation of wine materials also showed their high quality, not inferior to the wine material of the control sample.

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Bhatia, Smita. "Abstract IA22: Understanding causes of Inferior Survival in Adolescent and Young Adults with Acute Lymphoblastic Leukemia." In Abstracts: AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; October 2-4, 2020. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7755.disp20-ia22.

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Browe, Daniel P., Carrie A. Rainis, Patrick J. McMahon, and Richard E. Debski. "The Effect of Anterior Dislocation on the Mechanical Properties of the Inferior Glenohumeral Ligament." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80099.

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The glenohumeral joint is the most frequently dislocated major joint in the body with about 2% of the population dislocating their shoulders between the ages of 18 and 70 [1]. Instability due to permanent deformation of the glenohumeral capsule is commonly associated with dislocation [2]. Current surgical repair techniques for shoulder dislocations typically consist of plication of the glenohumeral capsule, or folding the tissue over on itself, to reduce redundancy in the capsule and restore stability to the shoulder. Up to 25% of patients who undergo surgery for a shoulder dislocation still experience pain, instability, and recurrent dislocation after surgery [3]. It is hypothesized that the mechanical properties of the glenohumeral capsule change in response to dislocation. In addition, the magnitude and location of these changes may have implications for the ideal location and extent of plication. Therefore, the objective of this study was to quantify the mechanical properties of the axillary pouch of the glenohumeral capsule in tension and shear after anterior dislocation.

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Sarigul-Klijn, Yasemin Maria, and Nesrin Sarigul-Klijn. "A Dynamic Response Model of Human Spine Under Superior-Inferior G Loads Using Voigt Viscoelastic Representation." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14445.

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Transportation systems subject the human body to varying levels of vibrations, which causes lower back pain. Some studies presents that exposure to vibrations of 1.3 m/s 2 for ten minutes a day can be harmful even for healthy people. With transportation systems being part of our daily lives it is useful to better predict the effects of vehicle induced oscillations on human via mathematical models. Anthropometry of a person is highly important when it comes to fitting the occupant to the seat with the restraint system together with their mass. Spaceflight travel further complicate matters since 4–6 cm increase in body height can occur during space flight and space vehicles must be designed to accommodate these changes.

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Najjar, Yousef S. H., and Taha K. Aldoss. "Waste Energy Utilization in Regenerative Gas Turbine Cycles." In 1986 Joint Power Generation Conference: GT Papers. American Society of Mechanical Engineers, 1986. http://dx.doi.org/10.1115/86-jpgc-gt-2.

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One of the ways that can be used to increase the efficiency of a shaft gas turbine engine is by installing a regenerative heat exchanger in one of the following two configurations: 1. after the low pressure turbine (usual case). 2. after the high pressure turbine (suggested). Analysis of ideal cycles as well as real cycle for both configurations is done by using a computer program, where the following parameters were studied: heat exchanger effectiveness, turbine efficiency, compressor efficiency, ratio of turbine inlet pressure to compressor delivery pressure (P3/P2), and maximum temperature ratio (T3/T1). From the sensitivity analysis for both configurations the usual configuration is inferior to the suggested in terms of the relative effects of compressor and turbine efficiencies on the overall efficiency and turbine inlet pressure on overall thermal efficiency and power output. However, the usual method is superior with respect to the relative effects of the compressor and turbine efficiencies on power output and flow path design and manufacture.

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Pedrosa, Lehilton L. C., Vinícius F. Dos Santos, and Rafael C. S. Schouery. "Uma Aproximação para o Problema de Alocação de Terminais." In I Encontro de Teoria da Computação. Sociedade Brasileira de Computação - SBC, 2018. http://dx.doi.org/10.5753/etc.2016.9834.

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No problema de centros dos p-terminais são dados um espaço métrico (V, d) e um conjunto D V 2 que representa demandas de fluxo. O objetivo é selecionar um subconjunto de V de tamanho p, denominado terminais, e associar cada demanda uv 2 D a um terminal w, de forma a minimizar o maior custo de percurso entre uma origem u, o terminal associado w e o destino v. Embora os problemas de alocação de terminais componham uma área bastante ativa nos últimos anos, ainda há poucos trabalhos de aproximação. Para o problema de centros dos p-terminais, nós verificamos um limitante inferior de 2 para o fator e obtemos um primeiro algoritmo de aproximação, com fator 3.

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Reports on the topic "Inferno 2"

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Saldanha, Ian J., Wangnan Cao, Justin M. Broyles, Gaelen P. Adam, Monika Reddy Bhuma, Shivani Mehta, Laura S. Dominici, Andrea L. Pusic, and Ethan M. Balk. Breast Reconstruction After Mastectomy: A Systematic Review and Meta-Analysis. Agency for Healthcare Research and Quality (AHRQ), July 2021. http://dx.doi.org/10.23970/ahrqepccer245.

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Objectives. This systematic review evaluates breast reconstruction options for women after mastectomy for breast cancer (or breast cancer prophylaxis). We addressed six Key Questions (KQs): (1) implant-based reconstruction (IBR) versus autologous reconstruction (AR), (2) timing of IBR and AR in relation to chemotherapy and radiation therapy, (3) comparisons of implant materials, (4) comparisons of anatomic planes for IBR, (5) use versus nonuse of human acellular dermal matrices (ADMs) during IBR, and (6) comparisons of AR flap types. Data sources and review methods. We searched Medline®, Embase®, Cochrane CENTRAL, CINAHL®, and ClinicalTrials.gov from inception to March 23, 2021, to identify comparative and single group studies. We extracted study data into the Systematic Review Data Repository Plus (SRDR+). We assessed the risk of bias and evaluated the strength of evidence (SoE) using standard methods. The protocol was registered in PROSPERO (registration number CRD42020193183). Results. We found 8 randomized controlled trials, 83 nonrandomized comparative studies, and 69 single group studies. Risk of bias was moderate to high for most studies. KQ1: Compared with IBR, AR is probably associated with clinically better patient satisfaction with breasts and sexual well-being but comparable general quality of life and psychosocial well-being (moderate SoE, all outcomes). AR probably poses a greater risk of deep vein thrombosis or pulmonary embolism (moderate SoE), but IBR probably poses a greater risk of reconstructive failure in the long term (1.5 to 4 years) (moderate SoE) and may pose a greater risk of breast seroma (low SoE). KQ 2: Conducting IBR either before or after radiation therapy may result in comparable physical well-being, psychosocial well-being, sexual well-being, and patient satisfaction with breasts (all low SoE), and probably results in comparable risks of implant failure/loss or need for explant surgery (moderate SoE). We found no evidence addressing timing of IBR or AR in relation to chemotherapy or timing of AR in relation to radiation therapy. KQ 3: Silicone and saline implants may result in clinically comparable patient satisfaction with breasts (low SoE). There is insufficient evidence regarding double lumen implants. KQ 4: Whether the implant is placed in the prepectoral or total submuscular plane may not be associated with risk of infections that are not explicitly implant related (low SoE). There is insufficient evidence addressing the comparisons between prepectoral and partial submuscular and between partial and total submuscular planes. KQ 5: The evidence is inconsistent regarding whether human ADM use during IBR impacts physical well-being, psychosocial well-being, or satisfaction with breasts. However, ADM use probably increases the risk of implant failure/loss or need for explant surgery (moderate SoE) and may increase the risk of infections not explicitly implant related (low SoE). Whether or not ADM is used probably is associated with comparable risks of seroma and unplanned repeat surgeries for revision (moderate SoE for both), and possibly necrosis (low SoE). KQ 6: AR with either transverse rectus abdominis (TRAM) or deep inferior epigastric perforator (DIEP) flaps may result in comparable patient satisfaction with breasts (low SoE), but TRAM flaps probably increase the risk of harms to the area of flap harvest (moderate SoE). AR with either DIEP or latissimus dorsi flaps may result in comparable patient satisfaction with breasts (low SoE), but there is insufficient evidence regarding thromboembolic events and no evidence regarding other surgical complications. Conclusion. Evidence regarding surgical breast reconstruction options is largely insufficient or of only low or moderate SoE. New high-quality research is needed, especially for timing of IBR and AR in relation to chemotherapy and radiation therapy, for comparisons of implant materials, and for comparisons of anatomic planes of implant placement.

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