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Dissertations / Theses on the topic 'Infertility factors'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Raberi, Araz. "Genetic contributory factors to infertility." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:4363762b-6c0b-465c-925a-ecc86e772220.

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Introduction: In recent years, the average age of first reproduction has risen significantly, the mean now standing at around 30 years in many countries. The adverse effects of maternal age on fertility and reproduction have been well documented. However, the influence of paternal age on fertility, reproduction and postnatal health is relatively poorly understood, and 50% of all male infertility cases are classed as idiopathic or unexplained infertility. Methods: The aim of this study was to investigate factors that contribute to male infertility, split into two main parts. The first part focu

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2

CAMPISCIANO, GIUSEPPINA. "Microbiota & infertility: microorganisms and immune factors in the idiopathic infertility." Doctoral thesis, Università degli Studi di Trieste, 2017. http://hdl.handle.net/11368/2908120.

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In the present work, the possible relationship between the idiopathic infertility, the alteration of the vaginal microbiota and that of the local immune response is investigated. The next-generation Ion Torrent PGM sequencing platform allowed the survey of the vaginal microbial composition, while the Luminex assay permitted the dosage of the soluble local immune mediators. After the analysis, the women affected by idiopathic infertility showed a vaginal microbiota similar to that of women affected by bacterial vaginosis (Chapter 1) and, especially, to those women who belong to the Intermediate

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3

Dumargne, Marie-Charlotte. "Genetic and epigenetic factors associated with human male infertility." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066068.

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La spermatogenèse est un processus complexe qui dépend de la coopération de nombreux gènes. Son produit final le spermatozoïde, est un sujet d’étude idéal car il renferme à la fois des indices d’événements passés ainsi que des informations qui seront transmises à l'ovocyte lors de la fécondation. L'identification de nouveaux acteurs de la spermatogenèse, des modifications spécifiques de l'ADN du sperme ou la présence de transcrits spécifiques pourraient servir comme biomarqueurs dans le diagnostic de l’infertilité. Cette thèse avait pour but d’analyser le génome, le transcriptome et l’épigénom

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4

Ng, Richard. "Factors affecting DNA methylation in the sperm of men with male factor infertility." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/63605.

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Infertility currently affects an estimated 8-12% of couples globally and the male factor is suspected as the primary cause in about half of these cases. There are several identified genetic causes for male infertility such as Y chromosome microdeletions and chromosomal rearrangements; however, these known genetic causes only account for 15-30% of male infertility cases, with the majority being idiopathic. Recently, there has been a shift toward studying epigenetic mechanisms as a potential avenue to explain idiopathic cases of male infertility. Most commonly, DNA methylation of imprinted genes

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5

Okonofua, Friday Ebhodaghe. "Female and male infertility in Nigeria : studies on the epidemiology of infertility in Nigeria with special reference to the role of genital tract infections and sexual and reproductive risk factors /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-354-X/.

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6

Gearon, Ceinwen Mary. "Factors affecting fertilisation following the micro-injection of human spermatozoa." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338678.

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7

Bretherick, Karla Lucia. "Genetic factors in premature ovarian failure." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/2444.

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Approximately 1% of women will experience menopause before the age of 40, a condition known as premature ovarian failure (POF). The goal of this thesis was to identify genetic causes of POF by examining a number of candidate factors in POF patients and control women. Carriers of FMR1 premutations (55-200 CGG repeats) are known to be at increased risk of POF. A higher prevalence of alleles between 35-54 repeats was found among POF patients (p=0.01), suggesting that risk for POF may extend outside the classic premutation range. There was no evidence for any difference in FMRI promoter methylatio

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8

Murto, Tiina. "Folate, Hormones and Infertility : Different factors affecting IVF pregnancy outcome." Doctoral thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-220476.

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Various hormones have been studied as regards prediction of pregnancy outcome after infertility treatment, but no ideal candidate has been found. Folate and genetic variations in folate metabolism have also been associated with infertility, but it remains unclear how these factors affect IVF pregnancy outcome. It is known that infertility is associated with active folic acid supplement use, but the effect of socioeconomic and lifestyle factors on folic acid supplement use in infertile women has not been well investigated. The overall aim of this work was to obtain information on the prediction

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9

Leung, Sum-po May. "The effect of psychosocial factors on the anxiety level of infertile women." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B29759018.

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10

Steuber, Keli Ryan Solomon Denise Haunani. "Infertility information management factors affecting individual disclosures and discrepancies between husbands and wives /." [University Park, Pa.] : Pennsylvania State University, 2009. http://etda.libraries.psu.edu/theses/approved/PSUonlyIndex/ETD-4503/index.html.

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11

Donkor, Ernestina Safoa. "The impact of perceived stigma and mediating social factors on infertility-related stress and coping strategies among women seeking infertility treatment in southern Ghana." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429981.

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12

Brewis, Alexandra Avril. "Age and infertility: An ethnodemographic study from Butaritari Atoll, Kiribati." Diss., The University of Arizona, 1992. http://hdl.handle.net/10150/185797.

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This biocultural study examines patterns of infertility, or failure to produce live births, by female age cohorts in the Micronesian population of Butaritari Atoll, Kiribati. Anthropological and demographic methods employed included analysis of census survey, reproductive history collection, structured and semi-structured interviews, participant observation, ethnohistorical research, vital registrations, and clinic records. Primary infertility levels are found to be extremely low in this population. This is argued to be a consequence of low risk of exposure to fertility-inhibiting disease, typ

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13

Altschuler, Rebecca, Julia Dodd, Madison Hinkle, and Gabrielle Caselman. "Exploration of Risk and Resiliency Factors for the Relationship Between Infertility and Sexual Functioning." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/7335.

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14

Al-Naser, Al Zekri Huda M. "Oligo/amenorrhoea : endocrine profiles, ovarian ultrasound, insulin resistan and anthropometric factors; relationships between insulin resistance and ovarian function." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360284.

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15

Oakley, Laura Louise. "The epidemiology of infertility : measurement, prevalence and an investigation of early life and reproductive risk factors." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2011. http://researchonline.lshtm.ac.uk/682432/.

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Estimated to affect one in six couples in the UK, infertility is an issue of great public health importance. This thesis provides a critical overview of the methodological issues in defining and studying infertility, and investigates the epidemiology of infertility, particularly prevalence and early life and reproductive risk factors. An initial literature review critically evaluated different approaches to defining and measuring infertility, and provided an overview of current prevalence, trends, and existing literature on the determinants of infertility. Two datasets were analysed for the in

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16

Vila, Ana Carolina Dias. "A ENDOMETRIOSE E SUA RELAÇÃO COM A INFERTILIDADE FEMININA E FATORES AMBIENTAIS." Pontifícia Universidade Católica de Goiás, 2007. http://localhost:8080/tede/handle/tede/3059.

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Made available in DSpace on 2016-08-10T10:55:16Z (GMT). No. of bitstreams: 1 ANA CAROLINA DIAS VILA.pdf: 321510 bytes, checksum: 6c026abb0d1e2ef6cc2b79d143f68f08 (MD5) Previous issue date: 2007-02-14<br>Scientific evidences show that our health is more related to our life style than to the hegemonic idea of its genetic and biological determination. Other factors that directly influence the existence of the so-called modern diseases include sedentarism, an unhealthy diet, the use of alcohol, tobacco and other drugs, the competition and the frenzy imposed by our daily life. One of the diseases

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17

Rajareddy, Singareddy. "Studies of phosphatidylinositol 3 kinase (PI3K) signaling pathway in mammalian ovarian follicle activation and development." Doctoral thesis, Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1378.

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18

Quessada, Marilze Alves. "Fatores de risco para gravidez ectópica em um hospital universitário." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/156007.

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Introdução: A gestação ectópica (GE) corresponde a 6% das mortes maternas no primeiro trimestre, seu diagnóstico está fundamentado em dois exames complementares: ultrassonografia transvaginal (USTV) e dosagem do β-hCG sérico. Contudo, um erro muito comum dos profissionais de saúde é apreciar somente o exame complementar, sem considerar o quadro clínico e os fatores de risco. Usando uma coorte teórica com mais de 800 pacientes com diferentes incidências de GE, Mol e col. propuseram dois modelos probabilísticos para seu diagnóstico: Modelo Fixo e Modelo Flexível. O Modelo Fixo propôs o uso de um

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19

黃穎泉 and Wing-chuen Richard Wong. "Stunted growth and infertility in transgenic mice overexpressing epidermal growth factor." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31223692.

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20

Wong, Wing-chuen Richard. "Stunted growth and infertility in transgenic mice overexpressing epidermal growth factor /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21301128.

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21

Kashir, Junaid. "The role of the oocyte activation factor PLCζ in human male factor infertility". Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558444.

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General consensus agrees that the oscillations in intracellular calcium (Ca2+) leading to oocyte activation are induced by a testis-specific phospholipase C, PLCzeta (PLCS). Strong evidence now indicates that certain types of human infertility are caused by failure of the sperm to activate the oocyte in an appropriate manner. Such sperm exhibit absent/reduced levels of PLCS, while molecular analysis of the PLCS gene in an infertile patient identified a substitution of a conserved histidine residue at position 398 of the PLCS protein sequence for a proline residue (H398P), leading to severely r

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22

Nguyen, Minh Huong. "Infertilité masculine : fragmentation de l'ADN spermatique, ségrégation méiotique et facteurs génétiques." Thesis, Brest, 2015. http://www.theses.fr/2015BRES0034/document.

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L'infertilité affecte environ 15% des couples et l'étiologie est masculine dans la moitié des cas.Cette thèse étudie trois facteurs de l'infertilité masculine et se divise en deux parties décrites ci-dessous. Dans la première partie,l'équipement chromosomique et la fragmentation de I'ADN spermatique dans les gamètes d'hommes infertiles ont été étudiés par la technique FISH et TUNEL. Chez 4 patients présentant une mosaïque gonosomique, un taux élevé de gamètes aneuploïdes et de fragmentation de I'ADN spermatique a été observé. Concernant les l3 patients ayant une anomalie chromosomique de struc

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23

Runesson, Liselotte. "CORRELATION BETWEEN ENDOMETRIAL MARKERS AND PREGNANCYOUTCOME IN WOMEN WITH UNEXPLAINED INFERTILITY." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-126380.

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<p>ABSTRACT</p><p>A defect implantation process is the major reason for unexplained infertility. Estrogen andprogesterone are steroid hormones preparing the endometrium for implantation. They mediatetheir effect through their receptors: estrogen receptor alpha and beta and progesteronereceptor A and B, respectively. Leukemia inhibitory factor (LIF), which is also important forimplantation, mediates its effect through LIF receptor and the coreceptor, gp130, and is downregulated by suppressors of cytokine signaling 1. The aim of the study was to compare thelevels of the steroid hormone receptors

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24

Voisin, Allison. "Physiologie de la réponse et de la tolérance immunes dans l'épididyme murin." Thesis, Université Clermont Auvergne‎ (2017-2020), 2018. http://www.theses.fr/2018CLFAC102.

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L’épididyme, organe clé de la fertilité masculine, est le lieu de maturation et de stockage des spermatozoïdes. Cependant, l’arrivée massive et tardive de ces cellules à la puberté, longtemps après la mise en place du répertoire du soi, en fait des cibles potentielles pour le système immunitaire qui risque de les détruire. Dans le même temps, l’épididyme est fréquemment la cible d’infections rétrogrades qui, non contrôlées, altèrent la fertilité. Par conséquent, l’épididyme doit mettre en place une réponse immunitaire efficace contre les agents pathogènes tout en établissant une tolérance enve

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25

Doan, Huyen Van. "ROLES OF HAND2 TRANSCRIPTION FACTOR IN UTERINE RECEPTIVITY AND DECIDUALIZATION." OpenSIUC, 2013. https://opensiuc.lib.siu.edu/dissertations/670.

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Blastocyst implantation is the process in which a competent blastocyst acquires the ability to tether into the mother endometrium. At the same time, the endometrial tissue undergoes the process of decidualization to support the anchoring of the blastocyst and provides the blastocyst with nutrition until the fully functional placenta is formed. Although the process of implantation and decidualization are under control of progesterone and estrogen, the precise mechanisms involved in this regulation are not fully understood. Here, we report the expression and function of a transcription factor, H

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26

Ma, Kun. "Isolation of a candidate gene family for the azoospermia factor (AZF) controlling human spermatogenesis." Thesis, Open University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294882.

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27

Malki, Marwa. "Correlations between unexplained infertility and single nucleotide polymorphism in the genes of leukemia inhibitory factor receptor and gp130." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-128921.

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<p>About 30 % of all infertile couples suffer from infertility of an unexplained cause. Leukemia inhibitory factor (LIF) is a glycoprotein produced by the endometrium and is an important cytokine in the implantation process. LIF exerts its biological functions through heterodimerization of its two receptors: LIF receptor (LIFR) and gp130. Point mutations in the LIF gene have been associated with female infertility. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in the genes of LIFR and gp130 could cause reduced fertility in women. To this end, 115 sampl

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28

Idahl, Annika. "Chlamydia trachomatis as a risk factor for infertility in women and men, and ovarian tumor development." Doctoral thesis, Umeå universitet, Obstetrik och gynekologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-22239.

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Background: Chlamydia trachomatis in women is a risk factor for tubal factor infertility and extra uterine pregnancies, but the impact of a C. trachomatis infection on male fertility is unclear. It is also hypothesized that persistent infection with C. trachomatis, or other microorganisms, might initiate/promote ovarian tumor development. The aims of the thesis were to study whether C. trachomatis serum antibodies in women and men had an impact on infertility diagnoses, semen characteristics, pregnancy rates and pregnancy outcomes; furthermore, to explore associations of C. trachomatis, and My

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29

Gontijo, Érica Eugênio Lourenço. "Comparação do sucesso na produção e qualidade de embriões entre um laboratório convencional e um laboratório ISO 5/7 e fatores relacionados a gravidez." Universidade Federal de Goiás, 2016. http://repositorio.bc.ufg.br/tede/handle/tede/6217.

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Submitted by Marlene Santos (marlene.bc.ufg@gmail.com) on 2016-09-15T14:30:16Z No. of bitstreams: 2 Tese- Érica Eugênio Lourenço Gontijo - 2016.pdf: 2253704 bytes, checksum: db396485a7f8b5e9945a2d3be4fa771b (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-09-15T15:27:32Z (GMT) No. of bitstreams: 2 Tese- Érica Eugênio Lourenço Gontijo - 2016.pdf: 2253704 bytes, checksum: db396485a7f8b5e9945a2d3be4fa771b (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<

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Ramadan, Walaa M. "The oocyte activation factor, phospholipase C zeta (PLCζ) : potential mechanisms of action and scope for human infertility treatment". Thesis, University of Oxford, 2013. https://ora.ox.ac.uk/objects/uuid:70fc8ed0-f9dc-4686-b728-2d473324209b.

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It is widely believed that the sperm-specific protein phospholipase C zeta (PLCζ) is released into the oocyte upon fusion and initiates calcium (Ca<sup>2+</sup>) oscillations which regulate oocyte activation. Reduced amounts, abnormal localisation patterns, and aberrant forms of PLCζ underlie certain types of male-factor infertility, prompting significant interest in the use of this fundamental protein as a clinical therapeutic agent or diagnostic marker. This thesis systematically addressed a range of outstanding questions relating to the expression, localisation, and therapeutic/di

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31

Minor, Agata. "DNA methylation at imprinted and non-imprinted genes in the sperm of men affected by severe male factor infertility." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/29282.

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Abnormal DNA methylation at imprinted and non-imprinted genes has been associated with spermatogenesis failure. However, little information is available regarding DNA methylation at those genes in men affected by severe male factor infertility. We hypothesized a higher incidence of aberrant DNA methylation would be present in the ejaculate and testicular sperm of men affected by severe male factor infertility compared to that in fertile control men. Furthermore, we hypothesized abnormal DNA methylation would also affect non-imprinted genes in the sperm of men affected by severe oligozoospermia

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32

Chung, Man-kin. "A study on the prevalence of AZFd Y-chromosome microdeletion in Hong Kong Chinese men with severe male factor infertility." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31971696.

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Chung, Man-kin, and 鍾文健. "A study on the prevalence of AZFd Y-chromosome microdeletion in Hong Kong Chinese men with severe male factor infertility." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31971696.

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34

Cabry-Goubet, Rosalie. "Impact des facteurs environnementaux sur la fertilité : rôles du tabac et des pesticides." Thesis, Amiens, 2018. http://www.theses.fr/2018AMIE0060/document.

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Objectifs : La thématique de recherche du service est l'étude de l'impact des facteurs environnementaux sur la fertilité des couples. Deux axes ont été développés : l'impact du tabac et celui des pesticides les plus utilisés dans la région, considérés comme facteurs confondants. Pour le travail de cette thèse nous avons pour objectif principal d'évaluer l'impact du tabagisme et de l'exposition aux pesticides sur la fertilité de couples grâce à l'analyse de questionnaires d'exposition, des paramètres d'AMP de couples infertiles, de dosages de nicotine (principal composé additif de la fumée de c

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Vigneron-Dousset, Brigitte. "Etudes de certains facteurs de croissance en biologie humaine : l'axe somatotrope et son exploration, les insulin-like growth factors et leurs activateurs de faible masse moléculaire, les facteurs de croissance et la fertilité masculine." Nancy 1, 1997. http://www.theses.fr/1997NAN19009.

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Le but de ce travail consiste en une approche destinée à préciser le rôle joué par certains facteurs de croissance dans les domaines de la croissance et de la fertilité. L'exploration de l'axe somatotrope et la contribution de ses différents acteurs ont permis de mieux cerner les mécanismes qui pourraient contribuer à l'accélération transitoire de la croissance constatée dans les mois suivant la transplantation rénale en dehors de toute thérapeutique par hormone recombinante. L'approche plus fondamentale concerne la purification et l'identification, à partir de sérum humain, d'un hexapeptide,

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Krausz, Csilla Gabriella. "Chromosome Y et l'infertilité chez l'homme." Paris 7, 2001. http://www.theses.fr/2001PA077209.

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Unkila-Kallio, Leila. "Infertility and its treatment : association with ovarian granulosa cell tumor and impact on vascular endothelial growth factor, leptin and selected tumour markers in serum." Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/unkila-kallio/.

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Ajrouche, Roula. "Facteurs de risque des leucémies aigues de l’enfant : analyse de l’enquête ESTELLE." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA11T044.

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Ce travail de thèse a porté sur l’étiologie des leucémies aigües (LA) de l’enfant, et s’est concentré sur les questions (1) du risque de LA chez les enfants conçus par assistance médicale à la procréation (AMP) ; (2) du rôle protecteur d’une supplémentation maternelle en acide folique ; (3) du rôle protecteur de l’exposition précoce à des facteurs induisant une stimulation du système immunitaire ; (4) d’un effet protecteur des antécédents d’allergie sur le risque de LA de l’enfant. Les données analysées proviennent de l’étude cas-témoins française, ESTELLE, réalisée en 2010-2011. Les cas ont é

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McKeithen, Danielle N. "The Role of the Inflammasome During Chlamydia Infection." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2016. http://digitalcommons.auctr.edu/cauetds/151.

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Chlamydia trachomatis (C. trachomatis) is the most prevalent sexually transmitted bacteria with devastating reproductive consequences that lead to tubal factor infertility (TFI). Recent studies have implicated apoptosis – associated speck – like protein containing a caspase recruitment domain (ASC) as an adaptor of inflammasomes that stimulate IL – 1β and IL – 18 secretion, pro – inflammatory cytokines with critical functions in host defense against a variety of pathogens. Therefore, for the first time, we are reporting the use of ASC-/- mice in a mouse model of Chlamydia infection that might

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Cerny, Katheryn L. "Steroid-dependent regulation of the oviduct: A cross-species transcriptomal analysis." UKnowledge, 2015. http://uknowledge.uky.edu/animalsci_etds/49.

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Reproductive success depends on a functional oviduct for gamete storage, maturation, fertilization, and early-conceptus development. The ovarian-derived sex steroids estradiol and progesterone are known to affect functionality of the oviduct. Advances in microarray and NanoString technology allow for gene expression analysis to increase understanding of processes critical for fertility. Studies were conducted to investigate mechanisms regulating oviductal function in cattle and mice by using the Bovine Gene 1.0 ST array and the Mouse Gene 430-2.0 arrays (Affymetrix Inc., CA), respectively. For

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Soligo, Adriana de Goes e. Silva 1974. "Prevalencia dos fatores trombofilicos em mulheres com infertilidade." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311746.

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Orientadores: Ricardo Barini, Egle Cristina Couto de Carvalho<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-08T19:49:25Z (GMT). No. of bitstreams: 1 Soligo_AdrianadeGoeseSilva_M.pdf: 464907 bytes, checksum: c9378bf0a2d1fe337908abb53f773dbe (MD5) Previous issue date: 2007<br>Resumo: Objetivo: determinar a prevalência dos fatores trombofílicos em mulheres inférteis. Método: estudo de corte transversal, no qual foram admitidas mulheres inférteis (atendidas em clínica privada) e submetidas à investigação de tro

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Laissue, Paul. "Approches gène candidat et QTL dans la recherche de facteurs génétiques étiologiques de l'insuffisance ovarienne prématurée et les avortements spontanés à répétition : implication des gènes BMP15, GDF9 et FOXD1." Paris 7, 2009. http://www.theses.fr/2009PA077023.

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Cette thèse porte sur la recherche de facteurs génétiques étiologiques de deux pathologies humaines fréquentes : l'insuffisance ovarienne prématurée et les avortements spontanés à répétition. Pour étudier ces thématiques j'ai abordé chacun des sujets par des approches expérimentales distinctes. Concernant l'insuffisance ovarienne prématurée (IOP), lorsque j'ai débuté mes travaux de thèse en 2005, une mutation dans le gène BMP15 avait été récemment associée à l'étiopathologie. Afin d'établir si des mutations dans BMP15 et dans son paralogue GDF9 sont une cause fréquente de ce type d'infertilité

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Ramos, Masdeu Laia. "Validació de l’anàlisi citogenètica exhaustiva de tot el complement cromosòmic en cèl·lula única: Aplicació translacional al Diagnòstic Genètic Preimplantacional per factor masculí." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/131330.

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El Diagnòstic Genètic Preimplantacional (DGP) permet realitzar el diagnòstic d’alteracions genètiques en embrions generats in vitro de parelles portadores o afectes de malalties monogèniques, per tal de seleccionar-ne els no afectes per a la seva transferència a l’úter matern. El cribratge d’aneuploïdies o PGS (preimplantation genetic screening), en canvi, consisteix en l’anàlisi de la citogenètica dels embrions per així seleccionar embrions euploides per a la seva transferència i així incrementar les taxes d’embaràs dels cicles de fecundació in vitro. El PGS pot dur-se a terme mitjançan

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Lindgren, Karin E. "The Histidine-rich Glycoprotein in Reproduction." Doctoral thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-300769.

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Infertility affects 15% of reproductive-aged couples. The milieu surrounding the growing embryo is of outmost importance, and should be optimised during in vitro fertilisation (IVF). Many biological processes, such as angiogenesis, coagulation, and immune processes need to be well regulated for a pregnancy to occur and progress normally. Histidine-rich glycoprotein (HRG) is a plasma protein that regulates components of these systems by building complexes with various ligands. A single nucleotide polymorphism (SNP) in HRG, denoted HRG C633T, seem to be of importance for IVF treatment outcomes.

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Kaskar, Khalied. "Optimizing embryo culture conditions and spent culture media analysis as predictors of embryo quality and pregnancy." University of the Western Cape, 2021. http://hdl.handle.net/11394/7924.

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Philosophiae Doctor - PhD<br>The aim of this thesis is first, to evaluate various culture conditions to improve embryo development, and secondly, to analyze spent culture media for any biomarkers that may be predictive of embryo health. Single-step and sequential culture media were compared in both Planer and EmbryoScope™ incubators. Single-step media resulted in better blastocyst development compared to sequential media and the EmbryoScope™ incubation system showed slight improvements in embryo development than the Planer system. The benefits of supplementing the culture medium with either in

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Pelzer, Elise Sarah. "Microbial colonisation of human follicular fluid and adverse in vitro fertilisation outcomes." Thesis, Queensland University of Technology, 2011. https://eprints.qut.edu.au/49122/1/Elise_Pelzer_Thesis.pdf.

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This study, investigating 263 women undergoing trans-vaginal oocyte retrieval for in vitro fertilisation (IVF) found that microorganisms colonising follicular fluid contributed to adverse IVF (pre-implantation) and pregnancy (post-implantation) outcomes including poor quality embryos, failed pregnancy and early pregnancy loss (< 37 weeks gestation). Some microorganisms also showed in vitro growth patterns in liquid media that appeared to be enhanced by the hormonal stimulation protocol used for oocyte retrieval. Elaborated cytokines within follicular fluid were also associated with adverse IVF

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Hwang, Fong-Chu, and 黃鳳祝. "The risk factors of primary infertility women." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/93820494865757320503.

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碩士<br>高雄醫學院<br>公共衛生學研究所<br>86<br>To explore the risk factors of primary infertility women, the study , adopting case-control study, picks 120 women treated for primary infertility at the obstetric department of Kaohsiung municipal women and children generically hospital as cases, and 120 women as a control group who delivered a healthy baby for the first time and had no history of infertility in d IOsame hospital, total sample size is 240.The results found the mean age, mean menarche age, m

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Liao, Kai-Wei, and 廖凱威. "Blood metals concentration and relevant factors in infertility and fertility women." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/89440355413489441474.

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碩士<br>臺北醫學大學<br>公共衛生學研究所<br>98<br>Objective This study investigated the relationship between metals exposure and relevant factors risk of infertility in women. Design Cross-sectional study. Sample Study participants consisted of 384 cases recruited at the center for reproductive medicine and infertility and 58 controls at the department of gynecology and obstetrics in Taipei, Taiwan. Methods A total of 384 participants were recruited from a hospital and provided written informed consent between August 2008 and March 2010. The participants were interviewed face-to-face by a trained interview

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Li, Chuan-Chen, and 李涓甄. "Factors Associated with Postpartum Depression among Women Who Conceived with Infertility Treatment." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/30272809688573871625.

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Koropatnick, Stephanie J. "Characteristics of the individual and the transition : mediating factors in the response to infertility." Thesis, 1992. http://hdl.handle.net/2429/3348.

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Using Schlossberg's (1981) model of adjustment to transitions in adulthood as a framework, an exploratory study was conducted of the factors mediating responses to involuntary primary infertility. Forty-three women and twenty-eight men who were seeking medical attention for infertility concerns at an Alberta Infertility clinic were recruited to complete five standardized self-report instruments and one researcher-designed survey measuring fourteen predictor variables and ten outcome variables. Predictor variables included four Characteristics of the Transition, including: diagnosis, duration,

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