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Journal articles on the topic 'Infiltratin'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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1

Liu, Jie, Huai Xiu Lu, Long Quan Shao, Bin Deng, Yuan Fu Yi, Jie Mo Tian, Wei Wei Zhang, and Ning Wen. "Evaluation of Glass Infiltration Speed within Dental CAD/CAM Alumina at Different Temperatures." Advanced Materials Research 177 (December 2010): 314–17. http://dx.doi.org/10.4028/www.scientific.net/amr.177.314.

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Objective: to investigate glass infiltrating rates (depth/time) within dental CAD/CAM alumina at different temperatures. Methods: micron α-alumina powder was prepared with cold isostastic pressure at 250 MPa and sintered at 1450°C. The presintered alumina specimens were then infiltrated with special glass at 1150°C, 1200°C and 1250 °C. The infiltrating depths and time to form the infiltrate at the different temperatures were evaluated. Results: As the infiltrating temperature increased, the viscosity of the infiltrating glass decreased, and the infiltrating depth increased. A 1 mm infiltration

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Murphy, Christopher, Erjon Agushi, Zhangjie Su, Rainer Hinz, Federico Roncaroli, and David Coope. "Quantitative Diffusion Tensor Imaging (DTI) Analysis Reveals Different Infiltrative Patterns of Oligodendrogliomas and Astrocytomas in Peri-Tumour White Matter." Neurosurgery 84, no. 5 (March 23, 2019): E273. http://dx.doi.org/10.1093/neuros/nyz001.ni2.

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Abstract INTRODUCTION Gliomas are highly infiltrative primary brain tumours. Glioma infiltration is difficult to identify clinically using conventional diagnostic imaging. We used diffusion tensor imaging (DTI) to identify glioma infiltration in peritumour white matter (WM) and characterized differences between histological subtypes. METHODS We recruited 8 patients with a histological diagnosis of grade II or III glioma and 10 healthy controls. We compared fractional anisotropy (FA) maps of each patient against the control group using SPM8 (Matlab 2014a) to identify regions of glioma infiltrat

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Rodríguez-Guerrero, Alejandro, Javier Narciso, Enrique Louis, and F. Rodríguez-Reinoso. "Reducing Threshold Pressure for Infiltration of Al-12Si Alloys into Carbon Particle Compacts by Placing a Thin Layer of Sn at the Infiltration Front." Materials Science Forum 539-543 (March 2007): 785–90. http://dx.doi.org/10.4028/www.scientific.net/msf.539-543.785.

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The oxide layer that usually covers the surface of liquid aluminum and its alloys, is one of the main factors that hinders infiltration of these alloys into graphite particle compacts. The oxide film increases the threshold pressure for infiltration and the porosity of the resulting composites is large because the wetting at the metal/carbon interface is reduced. Infiltrating graphite compacts with tin requires, however, a much lower pressure, less than half of that required to infiltrate the eutectic Al-12Si alloy. As the surface tension of tin is half that of the Al-12Si alloy, this result i

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Briscoe, D. M., J. S. Pober, W. E. Harmon, and R. S. Cotran. "Expression of vascular cell adhesion molecule-1 in human renal allografts." Journal of the American Society of Nephrology 3, no. 5 (November 1992): 1180–85. http://dx.doi.org/10.1681/asn.v351180.

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The expression of vascular cell adhesion molecule-1 (VCAM-1) in 11 human renal allograft biopsies and 3 normal kidney specimens was investigated by immunocytochemistry. VCAM-1 expression was correlated with the degree of CD3+ T cell infiltration and the clinicopathologic diagnosis of acute rejection. CD3+ infiltrates were seen in all biopsies with rejection, but not in normal biopsies or one with acute tubular necrosis, and were accompanied by CD68+ monocyte/macrophage infiltrates. In normal biopsies, VCAM-1 was present on occasional tubules, where its expression was patchy and restricted to t

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Seyboldt, Christoph, Mathias Liewald, and Daniel Heydt. "Production of Aluminium Based Interpenetrating Phase Composites Using Semi-Solid Forming." Key Engineering Materials 716 (October 2016): 502–9. http://dx.doi.org/10.4028/www.scientific.net/kem.716.502.

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The following paper deals with the production of Interpenetrating Phase Composites (IPC) using semi-solid forming technology. Therefore, adequate ceramic foams were selected and infiltrated by processing the aluminium alloy A356 in the semi-solid state. In the studies presented in this paper, the infiltrations of two ceramic materials (Al2O3 and SiC) with three different pore sizes (10, 20 and 30 ppi) were investigated. During the forming process the liquid phase fraction of the aluminium was varied to analyze infiltration effects in relation to the raw material´s liquid phase fraction. Afterw

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Lilbæk, G., and J. W. Pomeroy. "Laboratory evidence for enhanced infiltration of ion load during snowmelt." Hydrology and Earth System Sciences 14, no. 7 (July 29, 2010): 1365–74. http://dx.doi.org/10.5194/hess-14-1365-2010.

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Abstract. Meltwater ion concentration and infiltration rate into frozen soil both decline rapidly as snowmelt progresses. Their temporal association is highly non-linear and a covariance term must be added in order to use time-averaged values of snowmelt ion concentration and infiltration rate to calculate chemical infiltration. The covariance is labelled enhanced ion infiltration and represents the additional ion load that infiltrates due to the timing of high meltwater concentration and infiltration rate. Previous assessment of the impact of enhanced ion infiltration has been theoretical; th

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Lilbæk, G., and J. W. Pomeroy. "Evidence for enhanced infiltration of ion load during snowmelt." Hydrology and Earth System Sciences Discussions 7, no. 1 (February 24, 2010): 1431–57. http://dx.doi.org/10.5194/hessd-7-1431-2010.

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Abstract. Meltwater ion concentration and infiltration rate into frozen soil both decline rapidly as snowmelt progresses. Their temporal association is highly non-linear and a covariance term must be added in order to use time-averaged values of snowmelt ion concentration and infiltration rate to calculate chemical infiltration. The covariance is labelled enhanced infiltration and represents the additional ion load that infiltrates due to the timing of high meltwater concentration and infiltration rate. Previous assessment of the impact of enhanced infiltration has been theoretical; thus, expe

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Xiong, Ying, Zewei Wang, Quan Zhou, Han Zeng, Hongyu Zhang, Zhaopei Liu, Qiuren Huang, et al. "Identification and validation of dichotomous immune subtypes based on intratumoral immune cells infiltration in clear cell renal cell carcinoma patients." Journal for ImmunoTherapy of Cancer 8, no. 1 (March 2020): e000447. http://dx.doi.org/10.1136/jitc-2019-000447.

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BackgroundIncreasing evidence has elucidated the clinical significance of tumor infiltrating immune cells in predicting outcomes and therapeutic efficacy. In this study, we comprehensively analyze the tumor microenvironment (TME) immune cell infiltrations in clear cell renal cell carcinoma (ccRCC) and correlated the infiltration patterns with anti-tumor immunity and clinical outcomes.MethodsWe analyzed immune cell infiltrations in four independent cohorts, including the KIRC cohort of 533 patients, the Zhongshan ccRCC cohorts of 259 patients, the Zhongshan fresh tumor sample cohorts of 20 pati

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Moyo, Tamara K., Anass Bouchnita, Nathalie Eymard, Vitaly Volpert, and Mark J. Koury. "Effects of Bone Marrow Infiltration By Multiple Myeloma on Erythropoiesis." Blood 126, no. 23 (December 3, 2015): 2143. http://dx.doi.org/10.1182/blood.v126.23.2143.2143.

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Abstract Diseases that infiltrate the bone marrow disrupt erythropoiesis leading to anemia. In multiple myeloma (MM), anemia severity can be correlated with degree of marrow infiltration by myeloma cells. Infiltrating MM may impair the function and structure of erythroblastic islands (EBIs), the marrow erythropoietic niches. An EBI consists of a central macrophage surrounded by colony-forming units-erythroid/proerythroblasts (CFU-E/pro-EBs) and their progeny, the differentiating erythroblasts. Cytokines produced by MM cells, such as Fas ligand (FL), tumor necrosis factor (TNF), and TNF-related

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Delgado, Anna F., Markus Nilsson, Francesco Latini, Johanna Mårtensson, Maria Zetterling, Shala G. Berntsson, Irina Alafuzoff, Jimmy Lätt, and Elna-Marie Larsson. "Preoperative Quantitative MR Tractography Compared with Visual Tract Evaluation in Patients with Neuropathologically Confirmed Gliomas Grades II and III: A Prospective Cohort Study." Radiology Research and Practice 2016 (2016): 1–15. http://dx.doi.org/10.1155/2016/7671854.

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Background and Purpose.Low-grade gliomas show infiltrative growth in white matter tracts. Diffusion tensor tractography can noninvasively assess white matter tracts. The aim was to preoperatively assess tumor growth in white matter tracts using quantitative MR tractography (3T). The hypothesis was that suspected infiltrated tracts would have altered diffusional properties in infiltrated tract segments compared to noninfiltrated tracts.Materials and Methods.Forty-eight patients with suspected low-grade glioma were included after written informed consent and underwent preoperative diffusion tens

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Yang, Isaac, Seunggu J. Han, Michael E. Sughrue, Tarik Tihan, and Andrew T. Parsa. "Immune cell infiltrate differences in pilocytic astrocytoma and glioblastoma: evidence of distinct immunological microenvironments that reflect tumor biology." Journal of Neurosurgery 115, no. 3 (September 2011): 505–11. http://dx.doi.org/10.3171/2011.4.jns101172.

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Object The tumor microenvironment in astrocytomas is composed of a variety of cell types, including infiltrative inflammatory cells that are dynamic in nature, potentially reflecting tumor biology. In this paper the authors demonstrate that characterization of the intratumoral inflammatory infiltrate can distinguish high-grade glioblastoma from low-grade pilocytic astrocytoma. Methods Tumor specimens from ninety-one patients with either glioblastoma or pilocytic astrocytoma were analyzed at the University of California, San Francisco. A systematic neuropathology analysis was performed. All tis

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Lähde, S., K. Hyrynkangas, J. Merikanto, R. Pokela, K. Jokinen, and P. Kärkölä. "Computed Tomography and Mediastinoscopy in the Assessment of Resectability of Lung Cancer." Acta Radiologica 30, no. 2 (March 1989): 169–73. http://dx.doi.org/10.1177/028418518903000210.

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In order to assess the potential of computed tomography (CT) of the mediastinum and mediastinoscopy in the staging of lung cancer, 125 patients were examined. Of these, 104 underwent thoracotomy, at which there was no evidence of mediastinal tumour involvement in 79 while 25 patients had signs of tumour spread. The sensitivity and specificity of CT were 87.0 per cent and 95.8 per cent, respectively, in the detection of direct tumour extension with a mediastinal mass. When lymph node enlargement was the sole finding, CT did not provide any differentiation between benign and malignant lymphadeno

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Yang, Xia, Ying Long Bai, Meng Xu, and Shi Ju Guo. "Preparation and Properties of Cu-10Sn Alloy Infiltrated 316L Stainless Steel Composites." Advanced Materials Research 503-504 (April 2012): 552–55. http://dx.doi.org/10.4028/www.scientific.net/amr.503-504.552.

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A new method to produce powder metallurgy (P/M) 316L stainless steel matrix composite by pressureless infiltrating Cu-10Sn alloy was studied. The effect of various compaction pressures and infiltrating temperatures on the microstructure, mechanical properties and corrosion resistance was investigated. The results show that high density P/M 316L stainless steel matrix composite could be achieved by infiltration. A maximum relative density of 98% was achieved, provided that the porosity of the skeleton was controlled at 18%~22%. After infiltration, hardness of the samples increased from 49 HRB t

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Akbari, Hamed, Luke Macyszyn, Xiao Da, Michel Bilello, Ronald L. Wolf, Maria Martinez-Lage, George Biros, Michelle Alonso-Basanta, Donald M. O'Rourke, and Christos Davatzikos. "Imaging Surrogates of Infiltration Obtained Via Multiparametric Imaging Pattern Analysis Predict Subsequent Location of Recurrence of Glioblastoma." Neurosurgery 78, no. 4 (January 19, 2016): 572–80. http://dx.doi.org/10.1227/neu.0000000000001202.

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Abstract BACKGROUND: Glioblastoma is an aggressive and highly infiltrative brain cancer. Standard surgical resection is guided by enhancement on postcontrast T1-weighted (T1) magnetic resonance imaging, which is insufficient for delineating surrounding infiltrating tumor. OBJECTIVE: To develop imaging biomarkers that delineate areas of tumor infiltration and predict early recurrence in peritumoral tissue. Such markers would enable intensive, yet targeted, surgery and radiotherapy, thereby potentially delaying recurrence and prolonging survival. METHODS: Preoperative multiparametric magnetic re

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15

Torcellan, Tommaso, Henry R. Hampton, Jacqueline Bailey, Michio Tomura, Robert Brink, and Tatyana Chtanova. "In vivo photolabeling of tumor-infiltrating cells reveals highly regulated egress of T-cell subsets from tumors." Proceedings of the National Academy of Sciences 114, no. 22 (May 15, 2017): 5677–82. http://dx.doi.org/10.1073/pnas.1618446114.

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Immune therapy is rapidly gaining prominence in the clinic as a major weapon against cancer. Whereas much attention has been focused on the infiltration of tumors by immune cells, the subsequent fate of these infiltrates remains largely unexplored. We therefore established a photoconversion-based model that allowed us to label tumor-infiltrating immune cells and follow their migration. Using this system, we identified a population of tumor-experienced cells that emigrate from primary tumors to draining lymph nodes via afferent lymphatic vessels. Although the majority of tumor-infiltrating cell

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Jairajpuri, Zeeba Shamim, and Usha Agarwal. "Tumor Associated Macrophages-Friends Turned Foe? A Case Report and Review of Literature." Bangladesh Journal of Medical Science 11, no. 2 (July 31, 2012): 139–42. http://dx.doi.org/10.3329/bjms.v11i2.8928.

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Most malignant tumors are infiltrated by inflammatory cells and it has long been considered that such infiltrates may be evidence of a host response to the tumor. Although lymphocytes are prominent in the inflammatory infiltrate, macrophages are also present, often in considerable numbers. Breast carcinoma is one such tumor where tumor associated macrophages (TAM) have been reported to be widespread, more so in Western literature. There is paucity of information about the biological and prognostic significance of this phenomenon in India. Ours is a tertiary center which receives approximately1

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McDougall, J. R., and I. C. Pyrah. "Simulating transient infiltration in unsaturated soils." Canadian Geotechnical Journal 35, no. 6 (December 1, 1998): 1093–100. http://dx.doi.org/10.1139/t98-059.

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Transient responses to various infiltration events have been examined using an unsaturated flow model. Numerical simulations reveal a range of infiltration patterns which can be related to the ratio of infiltration rate to unsaturated hydraulic conductivity. A high value of this ratio reflects a prevailing hydraulic conductivity which cannot readily redistribute the newly infiltrated moisture. Moisture accumulates in the near-surface region before advancing down through the soil as a distinct wetting front. In contrast, low values of the ratio of rainfall to unsaturated hydraulic conductivity

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Giannakis, Marios, Jasmine Xinmeng Mu, Sachet Shukla, Zhi Rong Qian, Ofir Cohen, Reiko Nishihara, Yin Cao, et al. "Novel driver genes and genomic predictors of immune infiltrates in colorectal cancer." Journal of Clinical Oncology 34, no. 4_suppl (February 1, 2016): 557. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.557.

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557 Background: Despite progress that has been made in the molecular characterization of colorectal cancer (CRC), prior studies have had limited power to detect, as significantly mutated, less-frequently altered CRC genes. In addition, most large-scale sequencing studies have generally lacked clinicopathologic annotations to link genomic features with important CRC characteristics such as immune infiltration. Methods: We performed Whole-Exome Sequencing on 619 archival primary CRCs from two large prospective cohorts, the Nurses’ Health Study and the Health Professionals Follow-Up Study. We ide

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Fox, J. G., L. S. Palley, and R. Rose. "Eosinophilic Gastroenteritis with Splendore-Hoeppli Material in the Ferret (Mustela putorius furo)." Veterinary Pathology 29, no. 1 (January 1992): 21–26. http://dx.doi.org/10.1177/030098589202900103.

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Eosinophilic gastroenteritis, focal or diffuse with eosinophilic infiltrations of the stomach or intestine, has been described in human beings, cats, dogs, and horses. In this paper, we describe infiltration of the gastrointestinal tract with eosinophils accompanied by a circulating eosinophilia in six ferrets ( Mustela putorius furo). Clinical signs included chronic weight loss, anorexia, and diarrhea. The small intestines from five ferrets had diffuse infiltrates of eosinophils. This resulted in focal or multifocal loss of the muscular tunic in three ferrets. Two of these ferrets also had eo

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Chimanski, Afonso, Amanda Martins Jordão, Paulo Francisco Cesar, and Humberto Naoyuki Yoshimura. "Devitrification in SiO₂-B₂O₃-Al₂O₃-La₂O₃-TiO₂ Glass during the Infiltration of Ceramic Composite." Materials Science Forum 881 (November 2016): 77–82. http://dx.doi.org/10.4028/www.scientific.net/msf.881.77.

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Dental prostheses made of ceramic composites infiltrated with glasses have been used due to their biocompatibility and possibility to mimic the natural teeth. In this study, the devitrification behavior of 20SiO2-25B2O3-25Al2O3-15La2O3-15TiO2 glass during the infiltration process in a porous alumina preform was investigated. Glass frits were prepared by melting the raw materials at 1500 °C for 60 min. The glass was infiltrated into the alumina preform at 1,150 or 1,200 °C for 60 min. The specimens were characterized by X-ray diffraction analysis and scanning electron microscopy. After the infi

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Sams, Carl E., William S. Conway, Judith A. Abbott, Russell J. Lewis, and Noach Ben-Shalom. "Firmness and Decay of Apples following Postharvest Pressure Infiltration of Calcium and Heat Treatment." Journal of the American Society for Horticultural Science 118, no. 5 (September 1993): 623–27. http://dx.doi.org/10.21273/jashs.118.5.623.

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Heating `Golden Delicious' apples (Malus domestica Borkh.) for 4 days at 38C or pressure-infiltrating them with a 4% CaCl2 solution reduced decay and maintained fruit firmness during 6 months of storage at 0C. Heating reduced decay caused by Penicillium expansum Link ex Thorn by ≈30%, while pressure infiltration with CaCl2 reduced decay by >60%. Pressure infiltration with CaCl2 after heating reduced decay by ≈40%. Pressure infiltration maintained firmness best (>84 N), as measured with a manually driven electronic fruit-firmness probe, followed by heat and CaCl2 (76 N), heat alone (71 N)

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Sangam, Subhasri Lakshmi. "Quality improvement measures for early detection of severe intravenous infiltration in infants." BMJ Open Quality 8, no. 2 (June 2019): e000407. http://dx.doi.org/10.1136/bmjoq-2018-000407.

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Intravenous infiltration is one of the most commonly seen morbidity in infants admitted to the neonatal intensive care unit (NICU). The risk of intravenous infiltration in preterm infants is probably due to prolonged peripheral intravenous access requirement for nutritional support and usage of other intravenous medications to support their growth. Infants are more likely to develop intravenous infiltrations due to the increased fragility of their blood vessels, deficient subcutaneous tissue and inability to express pain. As a result, the intravenous infiltrates in infants can rapidly progress

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Laužikas, Giedrius, Gintaras Varanauskas, and Juozas Stanaitis. "Apendikulinio infiltrato diagnostikos ir gydymo ypatumai." Lietuvos chirurgija 2, no. 1 (January 1, 2004): 0. http://dx.doi.org/10.15388/lietchirur.2004.1.2377.

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Giedrius Laužikas, Gintaras Varanauskas, Juozas StanaitisVilniaus universiteto Bendrosios ir kraujagyslių chirurgijos klinikos Bendrosios chirurgijos centras,Vilniaus greitosios pagalbos universitetinė ligoninė,Šiltnamių g. 29, LT-2043 VilniusEl paštas: giedrius.lauzikas@vgpul.lt Įvadas / tikslas Apendikulinis infiltratas – viena iš ūminio apendicito formų, pasižyminti sudėtinga diagnostika ir gydymo ypatumais. Literatūroje diskutuojama, kuriam gydymo metodui – operaciniam ar konservatyviam – teikti pirmenybę. Mūsų darbo tikslas – apžvelgti apendikulinių infiltratų diagnostikos ir gydymo ypatu

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Baird, Joshua B., Ryan J. Winston, and William F. Hunt. "Evaluating the hydrologic and water quality performance of novel infiltrating wet retention ponds." Blue-Green Systems 2, no. 1 (January 1, 2020): 282–99. http://dx.doi.org/10.2166/bgs.2020.010.

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Abstract Wet retention ponds temporarily store and slowly release stormwater to mitigate peak flow rates and remove particulate-bound pollutants. However, with sandy underlying soils, wet retention ponds may provide additional benefits through infiltration, thereby recharging groundwater and supporting baseflow in streams. Current design guidance often requires lining wet ponds to prevent infiltration; however, modern stormwater management strategies recommend maximizing runoff volume reduction through infiltration. Two infiltrating wet retention ponds in Fayetteville, NC, USA, were monitored

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Yang, Shao Feng, Wei Ping Chen, Meng Yan Han, and De Zhi Zhu. "Microstructure and Interface Strength of MMCs Prepared by Pressureless Ni-Induced Infiltration Using Fe Alloy." Applied Mechanics and Materials 37-38 (November 2010): 652–57. http://dx.doi.org/10.4028/www.scientific.net/amm.37-38.652.

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Metal matrix composites (MMCs) were produced by Ni-induced pressureless infiltration using Fe alloy. The mainly fabrication process was that Ni and Al2O3 powders mixture was pressed and sintered after milled, and then the sintered Al2O3 ceramics were infiltrated by Fe alloy at 1600°C with 4h holding time. While the SEM and EPMA analyses indicated that the interface between ceramics and Fe alloy reaches a full homogeneity after infiltration and Fe alloy could infiltrate Al2O3 ceramic preforms and the maximum infiltration distance was more than 400 μm. This would increase the strength of interfa

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Weil, Andrew C., Matt E. Kalaycio, and James R. Cook. "Pulmonary Infiltration by CLL/SLL in the Presence of Inflammation: Significant or Incidental Finding?." Blood 114, no. 22 (November 20, 2009): 2352. http://dx.doi.org/10.1182/blood.v114.22.2352.2352.

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Abstract Abstract 2352 Poster Board II-329 Radiographically identified pulmonary infiltrates in patients with CLL are usually secondary to infectious causes. However, a subset of patients develop pathologic leukemic infiltrates. Lung biopsies containing both inflammation and CLL infiltrates are particularly problematic. It is unclear in such cases whether the CLL infiltrate represents a nonspecific “passenger effect” secondary to ongoing inflammation versus a pathologic leukemic infiltrate. Furthermore, it is unknown whether there are clinical factors that would help predict who is at higher r

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Zhang, Gui-rong, Ya-jun Qian, Zhang-chun Wang, and Bo Zhao. "Analysis of Rainfall Infiltration Law in Unsaturated Soil Slope." Scientific World Journal 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/567250.

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In the study of unsaturated soil slope stability under rainfall infiltration, it is worth continuing to explore how much rainfall infiltrates into the slope in a rain process, and the amount of rainfall infiltrating into slope is the important factor influencing the stability. Therefore, rainfall infiltration capacity is an important issue of unsaturated seepage analysis for slope. On the basis of previous studies, rainfall infiltration law of unsaturated soil slope is analyzed. Considering the characteristics of slope and rainfall, the key factors affecting rainfall infiltration of slope, inc

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Wirth, Thomas, Farizan Ahmad, Agnieszka Pacholska, Haritha Samaranayake, and Seppo Ylä-Herttuala. "The Syngeneic BT4C Rat Malignant Glioma is a Valuable Model to study Myelomonocytic cells in Tumors." Cancer Growth and Metastasis 5 (January 2012): CGM.S9314. http://dx.doi.org/10.4137/cgm.s9314.

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Background The impact of infiltrating macrophages on tumor progression in malignant gliomas has been studied extensively. However, there is a lack of animal models for studying the role of infiltrating macrophages in malignant gliomas. Material and methods: The BT4C rat malignant glioma model was characterized by immunohistochemical analysis of inflammatory cell types associated with the tumors. Results BT4C malignant gliomas are highly vascularized tumors with an infiltrative behavior. BT4C gliomas demonstrated a high infiltration rate of macrophages. Particularly, a CD68/VEGFR-1 positive sub

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Wang, Zhanchao, Huiqiao Wu, Yu Chen, Huajiang Chen, Wen Yuan, and Xinwei Wang. "The Heterogeneity of Infiltrating Macrophages in Metastatic Osteosarcoma and Its Correlation with Immunotherapy." Journal of Oncology 2021 (July 21, 2021): 1–13. http://dx.doi.org/10.1155/2021/4836292.

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Background. Metastatic osteosarcoma is a common and fatal bone tumor. Several studies have found that tumor-infiltrating immune cells play pivotal roles in the progression of metastatic osteosarcoma. However, the heterogeneity of infiltrating immune cells across metastatic and primary osteosarcoma remains unclear. Methods. Immune infiltration analysis was carried out via the “ESTIMATE” and “xCell” algorithms in primary and metastatic osteosarcoma. Then, we evaluated the prognostic value of infiltrating immune cells in 85 osteosarcomas through the Kaplan–Meier (K-M) and receiver operating chara

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Mukherjee, Geetashree, Swarnendu Bag, Prasenjit Chakraborty, Debdeep Dey, Samrat Roy, Prateek Jain, Paromita Roy, Richie Soong, Partha Pratim Majumder, and Suparna Dutt. "Density of CD3+ and CD8+ cells in gingivo-buccal oral squamous cell carcinoma is associated with lymph node metastases and survival." PLOS ONE 15, no. 11 (November 19, 2020): e0242058. http://dx.doi.org/10.1371/journal.pone.0242058.

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The tumor immune microenvironment is emerging as a critical player in predicting cancer prognosis and response to therapies. However, the prognostic value of tumor-infiltrating immune cells in Gingivo-Buccal Oral Squamous Cell Carcinoma (GBOSCC) and their association with tumor size or lymph node metastases status require further elucidation. To study the relationship of tumor-infiltrating immune cells with tumor size (T stage) and lymph node metastases (N stages), we analyzed the density of tumor-infiltrating immune cells in archived, whole tumor resections from 94 patients. We characterized

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Li, Taiwen, Jingxin Fu, Zexian Zeng, David Cohen, Jing Li, Qianming Chen, Bo Li, and X. Shirley Liu. "TIMER2.0 for analysis of tumor-infiltrating immune cells." Nucleic Acids Research 48, W1 (May 22, 2020): W509—W514. http://dx.doi.org/10.1093/nar/gkaa407.

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Abstract Tumor progression and the efficacy of immunotherapy are strongly influenced by the composition and abundance of immune cells in the tumor microenvironment. Due to the limitations of direct measurement methods, computational algorithms are often used to infer immune cell composition from bulk tumor transcriptome profiles. These estimated tumor immune infiltrate populations have been associated with genomic and transcriptomic changes in the tumors, providing insight into tumor–immune interactions. However, such investigations on large-scale public data remain challenging. To lower the b

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Kiser, Jackson William. "Quality improvement using new technology to assess and reduce FDG PET/CT radiotracer infiltrations." Journal of Clinical Oncology 36, no. 30_suppl (October 20, 2018): 313. http://dx.doi.org/10.1200/jco.2018.36.30_suppl.313.

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313 Background: The reported aggregated PET/CT 18F-FDG radiotracer injection infiltration rate from 3 centers in 6 studies is 15.2% (425 infiltrations/2804 patients). Infiltrations can negatively affect cancer patient staging, therapy assessment, treatment planning, and can lead to unnecessary invasive procedures and patient radiation exposure. The radiotracer dose is essential to PET image quality and quantification. Efforts are made to ensure the exact dose administered is used to create the patient image; but, no measures ensure the administered dose completely enters the patient circulatio

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Chae, Young Kwang, William Han Bae, Young Suk Kim, Jonathan Forrest Anker, Maria Matsangou, and Francis J. Giles. "Association of activated B-cell infiltration in the tumor microenvironment with regulatory T-cell (Treg) infiltration, but not macrophages polarization in immunogenic human cancers." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): e23174-e23174. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e23174.

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e23174 Background: We reported an inverse association between tumor-infiltrating B and CD8 T cells in human cancers. Preclinical studies suggested that B cells regulate T cell activities via activation of Treg cells and alternative polarization of macrophages. In this study, we investigated the relationship between B cell infiltration, Treg cell infiltration, and macrophage polarization in five human cancers approved for the use of immune checkpoint inhibitors by the FDA. Methods: mRNA expression scores of 812 immune-related genes from the TCGA database were analyzed to calculate tumor infiltr

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Loi, Sherene, Nicolas Sirtaine, Fanny Piette, Roberto Salgado, Giuseppe Viale, Françoise Van Eenoo, Ghizlane Rouas, et al. "Prognostic and Predictive Value of Tumor-Infiltrating Lymphocytes in a Phase III Randomized Adjuvant Breast Cancer Trial in Node-Positive Breast Cancer Comparing the Addition of Docetaxel to Doxorubicin With Doxorubicin-Based Chemotherapy: BIG 02-98." Journal of Clinical Oncology 31, no. 7 (March 1, 2013): 860–67. http://dx.doi.org/10.1200/jco.2011.41.0902.

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Purpose Previous preclinical and clinical data suggest that the immune system influences prognosis and response to chemotherapy (CT); however, clinical relevance has yet to be established in breast cancer (BC). We hypothesized that increased lymphocytic infiltration would be associated with good prognosis and benefit from immunogenic CT—in this case, anthracycline-only CT—in selected BC subtypes. Patients and Methods We investigated the relationship between quantity and location of lymphocytic infiltrate at diagnosis with clinical outcome in 2009 node-positive BC samples from the BIG 02-98 adj

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Nakahara, Yukiko, Hiroshi Ito, Motofumi Koguchi, Tomihiro Wakamiya, Jun Masuoka, and Tatsuya Abe. "NI-18 INVASIONS OF WHITE MATTER AS A PROGNOSTIC FACTOR IN LOW GRADE GLIOMAS." Neuro-Oncology Advances 1, Supplement_2 (December 2019): ii28—ii29. http://dx.doi.org/10.1093/noajnl/vdz039.129.

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Abstract INTRODUCTION Gliomatosis cerebri (GC), which was characterized by widespread infiltration of the brain involving three lobes, was deleted in the 2016 WHO classification. However, it is known that gliomas with GC growth pattern have a poor prognosis even in low histological grading. In this study, we focused on tumor invasion into white matter fibers. We analyzed the MRI findings focusing on white matter fibers and compared in patients with histologically proven low grade gliomas (LGGs) with GC pattern and localized LGGs. METHOD The patients can be classified into four groups according

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Gerlach, Magdalena M., Darius Juskevicius, Visar Vela, Stefan Dirnhofer, and Alexandar Tzankov. "Bone Marrow Infiltration of Angioimmunoblastic T-Cell Lymphoma: Identification and Prognostic Impact of Histologic Patterns and Diagnostic Application of Ancillary Phenotypic and Molecular Analyses." Archives of Pathology & Laboratory Medicine 144, no. 5 (September 26, 2019): 602–11. http://dx.doi.org/10.5858/arpa.2019-0007-oa.

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Context.— Angioimmunoblastic T-cell lymphomas originate from T follicular helper cells and express respective markers (BCL6, CD10, CXCL13, ICOS, and PD-1). Although commonly present, bone marrow involvement by angioimmunoblastic T-cell lymphoma can be diagnostically challenging. Additionally, only little is known about the distribution of T follicular helper cells in healthy and reactively changed bone marrows or in samples affected by other lymphomas. Objective.— To establish a diagnostic approach to reliably identify bone marrow infiltration of angioimmunoblastic T-cell lymphoma. Design.— We

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Bai, Johnny Wei, Dong An, Anahi Perlas, and Vincent Chan. "Adjuncts to local anesthetic wound infiltration for postoperative analgesia: a systematic review." Regional Anesthesia & Pain Medicine 45, no. 8 (May 30, 2020): 645–55. http://dx.doi.org/10.1136/rapm-2020-101593.

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Local anesthetics (LAs) are commonly infiltrated into surgical wounds for postsurgical analgesia. While many adjuncts to LA agents have been studied, it is unclear which adjuncts are most effective for co-infiltration to improve and prolong analgesia. We performed a systematic review on adjuncts (excluding epinephrine) to local infiltrative anesthesia to determine their analgesic efficacy and opioid-sparing properties. Multiple databases were searched up to December 2019 for randomized controlled trials (RCTs) and two reviewers independently performed title/abstract screening and full-text rev

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Brandt, Sabine, Tobias M. Ballhause, Anja Bernhardt, Annika Becker, Delia Salaru, Hien Minh Le-Deffge, Alexander Fehr, et al. "Fibrosis and Immune Cell Infiltration Are Separate Events Regulated by Cell-Specific Receptor Notch3 Expression." Journal of the American Society of Nephrology 31, no. 11 (August 28, 2020): 2589–608. http://dx.doi.org/10.1681/asn.2019121289.

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BackgroundKidney injuries that result in chronic inflammation initiate crosstalk between stressed resident cells and infiltrating immune cells. In animal models, whole-body receptor Notch3 deficiency protects from leukocyte infiltration and organ fibrosis. However, the relative contribution of Notch3 expression in tissue versus infiltrating immune cells is unknown.MethodsChimeric mice deficient for Notch3 in hematopoietic cells and/or resident tissue cells were generated, and kidney fibrosis and inflammation after unilateral ureteral obstruction (UUO) were analyzed. Adoptive transfer of labele

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Rasulic, Lukas, and Milan Jovanovic. "Surgical treatment and dilemmas in the treatment of basal cell carcinomas with intracranial propagation." Vojnosanitetski pregled 71, no. 11 (2014): 1045–48. http://dx.doi.org/10.2298/vsp1411045r.

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Background/Aim. Basal cell carcinoma (BCC) is one of the most common malignant skin tumors on the head in 90% of cases and is characterized by a high local infiltrating potential and destructive growth. The aim of this study was to show the characteristics of a correlation between pathohistological types of basal cell carcinoma and the size of this lesion, aggressiveness and infiltration of basal cell carcinoma, and its effect on the course of the therapy. Methods. We analyzed 27 patients operated on for BCC that affected the scalp and the bone. We described and considered the clinical charact

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Movrin, Dejan, Ognjan Luzanin, and Vera Guduric. "Using statistically designed experiment to optimize vacuum-assisted post-processing of binder jetted specimens." Rapid Prototyping Journal 25, no. 3 (April 8, 2019): 653–63. http://dx.doi.org/10.1108/rpj-07-2018-0177.

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PurposeThis paper aims to propose a vacuum-assisted post-processing method for use in binder jetted technology. The method is based on six key technological parameters and uses standard, commercially available consumables to achieve improvement in tensile strength, as well as the microstructure and porosity of the infiltrated matrix.Design/methodology/approachSix key technological parameters were systematically varied as factors on three levels, using design of experiment, i.e. definitive screening design. Surface response methodology was used to optimize the process and yield optimal tensile

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Y.*, Olotu, Parker-Ikharo F, Rodiya A.A., Evboifo N.O, and Jibril A.A. "Development and Calibration of Automated Multiple-Ring Infiltrometer." Indian Journal of Production and Thermal Engineering 1, no. 3 (August 10, 2021): 6–9. http://dx.doi.org/10.35940/ijpte.c2016.081321.

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An automatic triple-ring infiltrometer was developed using a set of pre-set sensors and transducer (AP 403, AP 404, AP 405 and AP 406, RAP001 and RAP002). The aluminum probe sensors were graduated and arranged in series to monitor the rate at which water is infiltrating into the soil layer. The working principle of automatic triple-ring infiltrometer was developed using six probes with depth calibration of 1.0mm, 26.7 mm, 12.4 mm, and 12.7 mm, respectively. The result obtained showed strong agreement with a coefficient of determination R2= 0.963, indicating positive proportionality between cum

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Sabbatino, Francesco, Lucia Milham, Vikram Deshpande, Ioannis T. Konstantinidis, Andrew X. Zhu, Daniela Dias Santos, Nabeel Bardeesy, et al. "Variability in immune infiltrates and HLA expression in cholangiocarcinoma." Journal of Clinical Oncology 32, no. 3_suppl (January 20, 2014): 230. http://dx.doi.org/10.1200/jco.2014.32.3_suppl.230.

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230 Background: Cholangiocarcinoma continues to have a dismal prognosis. The lack of effective therapy prompted us to determine whether patients develop an immune response against their own tumors. The aim of this study is to evaluate the CD8 infiltrate and expression of HLA class I antigen processing machinery (APM) components in cholangiocarcinoma. The HLA class I antigen processing machinery (APM) components play a crucial role in expression of HLA class I tumor antigen derived peptide complexes. These complexes mediate the recognition of tumor cells by cognate T cells. Defects in the expre

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Merzkirch, Matthias, Pascal Pinter, Stefan Dietrich, and Kay André Weidenmann. "Interpenetrating Freeze Cast Composites: Correlation between Structural and Mechanical Characteristics." Materials Science Forum 825-826 (July 2015): 109–16. http://dx.doi.org/10.4028/www.scientific.net/msf.825-826.109.

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Ceramic freeze cast preforms based on alumina show an anisotropic behavior due to directional freezing during preform production. Beside the specific characteristics such as alumina content and lamellae spacing also the distribution of the so-called domains – regions with a relatively homogeneous orientation of alumina lamellae – play an important role considering stiffness and strength. The gas pressure infiltration process was used for infiltrating the freeze cast preforms with a eutectic aluminum/silicon alloy with a low melting point. Selected regions taken from the freeze cast preform hav

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Mahadevappa, Asha, Vanisri H. Raghavan, Sunila Ravishankar, and Gubbanna V. Manjunath. "Congenital Infiltrating Lipomatosis of the Face: A Case Report." Case Reports in Pediatrics 2012 (2012): 1–3. http://dx.doi.org/10.1155/2012/134646.

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Congenital infiltrating lipomatosis of the face is a rare lesion that comprises a subgroup of lipomatous tumor-like lesions of infancy and childhood. It is characterized by (1) no encapsulation, (2) diffuse infiltration of mature adipose tissue over normal muscle fiber and surrounding structures of face, (3) osseous hyperplasia of subjacent bone, and (4) a high recurrence rate. We report a case of a nine-month-old infant who presented with swelling over right face since birth. Early diagnosis of this lesion provides better surgical approach to control the infiltrative nature of its growth with

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Cui, Ben Cang, Jing Li, Hui Ning Wang, Yuan Hua Lin, Yang Shen, Ming Li, and Ce Wen Nan. "Mechanical Properties of Polymer-Infiltrated-Feldspar for Restorative Composite CAD/CAM Blocks." Key Engineering Materials 697 (July 2016): 648–51. http://dx.doi.org/10.4028/www.scientific.net/kem.697.648.

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Polymer-infiltrated-feldspar used for restorative composite CAD/CAM blocks were prepared by infiltrating polymerizable monomers into the partially sintered feldspar blocks. The flexural strength was tested according to the standard of ISO-4049. The micro-structure was examined by SEM. The effects of sintering temperature, high pressure and the addition of SiO2 and Al2O3 on the ultimate flexural strength were evaluated. The flexural strength corresponding to infiltration with pressure was much higher than that without pressure at high sintering temperature. The addition of SiO2 and Al2O3 into t

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Coscia, Ilaria, Niklas Linde, Stewart Greenhalgh, Tobias Vogt, and Alan Green. "Estimating traveltimes and groundwater flow patterns using 3D time-lapse crosshole ERT imaging of electrical resistivity fluctuations induced by infiltrating river water." GEOPHYSICS 77, no. 4 (July 1, 2012): E239—E250. http://dx.doi.org/10.1190/geo2011-0328.1.

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The infiltration of river water into aquifers is of high relevance to drinking-water production and is a key driver of biogeochemical processes in the hyporheic and riparian zone, but the distribution and quantification of the infiltrating water are difficult to determine using conventional hydrological methods (e.g., borehole logging and tracer tests). By time-lapse inverting crosshole ERT (electrical resistivity tomography) monitoring data, we imaged groundwater flow patterns driven by river water infiltrating a perialpine gravel aquifer in northeastern Switzerland. This was possible because

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Pupa, S. M., R. Bufalino, A. M. Invernizzi, S. Andreola, F. Rilke, L. Lombardi, M. I. Colnaghi, and S. Ménard. "Macrophage infiltrate and prognosis in c-erbB-2-overexpressing breast carcinomas." Journal of Clinical Oncology 14, no. 1 (January 1996): 85–94. http://dx.doi.org/10.1200/jco.1996.14.1.85.

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PURPOSE Experiments were designed to investigate the association between tumor leukocytic infiltrates with other pathologic and biologic variables in primary tumors and with prognosis, and to define the phenotype of the infiltrating leukocytes. PATIENTS AND METHODS A retrospective series of 1,207 primary breast carcinomas was studied according to different prognostic variables, including the presence of lymphoplasmacytic infiltrate (LPI). LPI was analyzed in association with other variables and survival. Additionally, a small prospective series of surgical specimens from 75 primary breast carc

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Bachireddy, Pavan, Ursula Hainz, Michael Rooney, Olga Pozdnyakova, Julie Aldridge, W. Nicholas Haining, Natalie R. Goldstein, et al. "Reversal of T Cell Exhaustion in Pre-Treatment Marrow T Cells Is Associated with Effective Graft-Versus-Leukemia Responses to Donor Lymphocyte Infusion." Blood 120, no. 21 (November 16, 2012): 1903. http://dx.doi.org/10.1182/blood.v120.21.1903.1903.

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Abstract Abstract 1903 Donor lymphocyte infusion (DLI) can provide curative treatment for relapsed hematologic malignancies following allogeneic hematopoietic stem cell transplant (HSCT). However, the precise mechanism by which DLI eliminates leukemia cells in vivo has not been established. We hypothesized that marrow-infiltrating immune populations play a critical role in DLI responses since marrow is the primary site of disease and a reservoir of high-avidity antigen-specific memory T cells that can recognize tumor antigens, therefore potentially mediating graft-versus-leukemia (GvL) respons

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Paus, Kim H., Tone M. Muthanna, and Bent C. Braskerud. "The hydrological performance of bioretention cells in regions with cold climates: seasonal variation and implications for design." Hydrology Research 47, no. 2 (October 1, 2015): 291–304. http://dx.doi.org/10.2166/nh.2015.084.

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Three bioretention cells in Norway were monitored for 23 to 36 months to evaluate the hydrological performance of bioretention cells operated in regions with cold climates and to test if cell size equations can be used to predict hydrological performance. Values of saturated hydraulic conductivity (Ksat) were determined for separate events by analyzing the observed infiltration rates and via infiltration tests. The two cells with the highest Ksat values (15.9 and 45.0 cm/h) performed excellently during the study period infiltrating nearly all of the incoming runoff. In contrast, the cell with

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Cheong, C. J., and M. Okada. "Effects of spilled oil on the tidal flat ecosystem - evaluation of wave and tidal actions using a tidal flat simulator." Water Science and Technology 43, no. 2 (January 1, 2001): 171–77. http://dx.doi.org/10.2166/wst.2001.0087.

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The purpose of this study is to clarify the effects of wave and tidal actions on the penetration of spilled oil stranded on tidal flats and to evaluate the influence of the penetrated oil on seawater infiltration using tidal flat simulator. A simulator used was composed of tidal flat, wave maker, tide controlling device, temperature controlling system and computer controlling system. The infiltrations of seawater and fuel oil C into tidal flats were visualized using transparent glass beads as tidal flat sediments. Penetration behaviour of the spilled oil into the sediments was significantly di

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