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Journal articles on the topic 'Inflammation and endogenous intoxication'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Lishnevska, Anastasiia, Mykola Chemych, Oksana Chemych, and Igor Chernetsky. "Immunoreactivity and intoxication syndrome in patients with chronic viral hepatitis c." Bangladesh Journal of Medical Science 22, no. 3 (2023): 508–14. http://dx.doi.org/10.3329/bjms.v22i3.65314.

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Method: Etiological, gender, age and laboratory characteristics of chronic viral hepatitis C (СVHC) were studied and analyzed. The distribution of patients depending on the virus genotype, the activity degree and the severity of liver fibrosis were found out. Indices of non-specific reactivity, endogenous intoxication and inflammation in the course of СVHC, their dependence on treatment were studied. Correlations between the values of non-specific reactivity, endogenous intoxication, inflammation and patients’ affiliation to the group of injecting drug users, the APRI score, the stage of liver

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2

Kutukova, S. I., N. P. Belyak, J. V. Ivaskova, A. Ya Razumova, N. V. Pakhomova, and N. A. Frolov. "Systemic inflammation in salivary gland cancer." Scientific Notes of the Pavlov University 29, no. 3 (2022): 74–80. http://dx.doi.org/10.24884/1607-4181-2022-29-3-74-80.

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Relevance. The inflammatory process and endogenous intoxication of the patient’s body has a negative impact on the course of many malignant neoplasms, including salivary gland cancer.The objective of the study was to determine the influence of some factors of systemic inflammation and endogenous intoxication in salivary gland cancer.Methods and materials. A prospective study included the data of 59 patients with salivary gland cancer. The influence of peripheral blood parameters and relative indicators characterizing systemic inflammation on overall and disease-free survival was assessed.Resul

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3

Svitailo, V. S., and M. D. Chemych. "INTEGRATIVE INDICATORS OF ENDOGENOUS INTOXICATION, INFLAMMATORY ACTIVITY, AND SPECIFIC REACTIVITY IN PATIENTS WITH COVID-19." Інфекційні хвороби, no. 3 (October 11, 2024): 21–27. http://dx.doi.org/10.11603/1681-2727.2024.3.14873.

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The aim of the study is to identify changes in blood laboratory parameters, integrative indicators of endogenous intoxication, inflammation, and specific reactivity in patients with coronavirus disease. Patients and methods. The study included 77 patients with COVID-19, taking into account the inclusion and exclusion criteria. The comparison group consisted of 68 practically healthy people of the corresponding age. Laboratory blood tests were performed, on the basis of which integrative indicators of endogenous intoxication, inflammation and specific reactivity were calculated. Results. The da

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4

Radchenko, O. M., O. V. Fedyk, and R. R. Guta. "HEMATOLOGICAL INDIXES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH ANEMIA." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 19, no. 3 (2019): 71–74. http://dx.doi.org/10.31718/2077-1096.19.3.71.

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A retrospective analysis of 470 patients with chronic obstructive pulmonary disease and anemia was conducted in order to determine hematological indices. 17 markers of inflammation activity, endogenous intoxication, adaptation, nonspecific and immune reactivity were calculated during this analysis. It was established that the course of chronic obstructive pulmonary disease with anemia was accompanied by a more pronounced inflammation syndrome with a significant increase in stab and segmented neutrophilic granulocytes, an acceleration of the erythrocyte sedimentation rate, and significantly hig

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Chemych, Mykola, Anastasiia Cherkashyna, and Oksana Chemych. "FEATURES OF CHANGES IN INTEGRATIVE INDICATORS OF ENDOGENOUS INTOXICATION, REACTIVITY, INFLAMMATION ACTIVITY IN PATIENTS WITH CHRONIC VIRAL HEPATITIS AND CHRONIC RENAL FAILURE." Eastern Ukrainian Medical Journal 11, no. 4 (2023): 461–70. http://dx.doi.org/10.21272/eumj.2023;11(4):461-470.

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The aim: to study the peculiarities of changes in integrative indicators of endogenous intoxication, reactivity and activity of inflammation in patients with chronic viral hepatitis B and C, and with chronic renal failure undergoing hemodialysis. Materials and methods. 19 patients with chronic viral hepatitis B (HBV) and chronic viral hepatitis C (HCV) with chronic renal failure and patients with chronic kidney disease (KD) were examined. Comparison group included 40 healthy blood donors. Epidemiological, clinical and laboratory examination was performed. Indicators of endogenous intoxication,

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6

G.Sh., Qarayev, Shadlinski V.B., and Khidirova H.F. "Dynamics Of Changes Of Inflammation Markers Depending On The Duration Of Toxicosis." Journal of Life Sciences and Biomedicine 72, no. 3 (2017): 148–51. https://doi.org/10.5281/zenodo.8102568.

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The aim of the research was to study the changes in the dynamics of inflammation during exotoxicosis. The study was conducted on 16 chinchilla rabbits. The model of exotoxicosis was made in a special chamber by inhalation with HCl vapors. The blood taken from the animals of the experimental group was examined to determine the content of peptide molecules, total bilirubin, creatinine and the amount of thymol. It has been revealed that exogenous intoxication primarily causes inflammation in the body, and then this process turns into endogenous intoxication.

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Mashkova, T. A., I. I. Chirkova, O. N. Yamshchikov, I. Yu Revyakin, V. A. Ershova, and A. A. Pudovkin. "Endogenous intoxication in chronic pathology of pharynx in children." Russian Otorhinolaryngology 20, no. 3 (2021): 94–101. http://dx.doi.org/10.18692/1810-4800-2021-3-94-101.

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A review of scientific Russian and foreign articles devoted to the development of endogenous intoxication in chronic inflammatory pathology of the lymphoepithelial pharyngeal ring is carried out. Chronic tonsillitis and adenoiditis in children are one of the unsolved issues in otorhinolaryngology. Chronic tonsillitis is a chronic inflammation of the palatine tonsils characterized by recurrent exacerbations in the form of tonsillitis and a general toxic-allergic reaction. Adenoid vegetation is a pathological hypertrophy of the pharyngeal tonsil. Chronic adenoiditis is a chronic polyetiologic di

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8

Saienko, Oleksandr, and Mykola Chemych. "CHANGES IN INDICATORS OF ENDOGENOUS INTOXICATION, NONSPECIFIC REACTIVITY, AND INFLAMMATION CAUSED BY SARS-COV-2." Eastern Ukrainian Medical Journal 12, no. 2 (2024): 422–30. http://dx.doi.org/10.21272/eumj.2024;12(2):422-430.

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Introduction: Despite the fact that the entire scientific world is concerned about COVID-19, about 65 million people are living with Long COVID, suffering from general weakness, fatigue, cognitive dysfunction, and shortness of breath. This problem is global for humanity because of the decrease in the ability to work and mental activity of the population, which leads to economic losses. The problem remains open and requires further research. Materials and Methods: a total of 108 patients were examined and divided into three groups: group A – 31 patients with confirmed COVID-19, group B – 35 pat

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9

PROKOFYEVA, TATIANA V., OLGA S. POLUNINA, and EKATERINA A. POLUNINA. "PROGNOSIS OF SIGNIFICANT ISCHEMIC EVENTS AND LETHAL OUTCOME IN PATIENTS WITH MYOCARDIAL INFARCTION WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE." Bulletin of Contemporary Clinical Medicine 16, no. 2 (2023): 49–55. http://dx.doi.org/10.20969/vskm.2023.16(2).49-55.

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Introduction. Myocardial infarction remains significant due to its high prevalence and disability. Of particular importance is the prediction of the risk of adverse events in myocardial infarction patients with cardiorespiratory comorbidity, in particular with chronic obstructive pulmonary disease. It can be assumed that endogenous intoxication syndrome can be considered as a predictor of life-threatening events (repeated myocardial infarction, stroke) and lethal outcome in patients with myocardial infarction against chronic obstructive pulmonary disease. Aim. The aim is to determine the proba

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10

Snarskaya, Elena S., L. M. Shnahova, and D. A. Shperling. "VARIATIONS OF MICROBIOCENOSIS AND ACID-BASE BALANCE OF THE SKIN WITH ACNE VULGARIS AND THE POSSIBILITY OF THEIR CORRECTION WITH EUBIOTIC COMPLEX." Russian Journal of Skin and Venereal Diseases 21, no. 2 (2018): 125–29. http://dx.doi.org/10.18821/1560-9588-2018-21-2-125-129.

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Presents a modern concept of the pathogenesis of acne vulgaris, data on the role of microbial factors and dysbiotic disorders in the development of endogenous intoxication. Endogenous intoxication syndrome (EIS) has a damaging effect on tissues, forming a complex of metabolic disorders that lead not only to suppression of the immune system organs functions, but also to interaction impairments of its individual effector links, causing the tendency of the macroorganism to nonspecific types of inflammation. The use of eubiotic complex “Eubikor” in the complex therapy of acne vulgaris leads to the

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11

Radchenko, O. M., and O. V. Fedуk. "Clinical and Pathophysiological Phenotyping of Chronic Obstructive Pulmonary Disease." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 6, no. 4 (2021): 105–10. http://dx.doi.org/10.26693/jmbs06.04.105.

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The purpose of the study was to determine the clinical and laboratory features of inflammatory phenotypes among patients with chronic obstructive pulmonary disease, moderate respiratory failure and anemia of chronic disease. Materials and methods. The study included 150 patients with exacerbation of chronic obstructive pulmonary disease and chronic anemia, in which inflammatory phenotypes were identified, among which the largest share was neutrophilic (66/44.0±4.0%), less lymphocytic (35/23.3±3.4%) and eosinophilic (16/10.7±2.5%). In 33/22.0% of patients, the inflammatory phenotype was mixed a

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Ushakova, N. D., D. A. Rozenko, S. N. Tikhonova, D. A. Kharagezov, and N. N. Popova. "Clinical and pathogenetic justification for the use of therapeutic plasma exchange in the complex of preoperative preparation of patients with non-small cell lung cancer complicated by the inflammatory process." South Russian Journal of Cancer 5, no. 1 (2024): 6–16. http://dx.doi.org/10.37748/2686-9039-2024-5-1-1.

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Purpose of the study. Determination of pathogenetic substantiation and indication criteria for the inclusion of extracorporeal detoxification methods in preoperative preparation of patients with non-small cell lung cancer (NSCLC) complicated by inflammation.Patients and methods. This study included the data on 222 patients with newly diagnosed stage I–IV NSCLC referred for elective surgical treatment to the Department of Thoracic Oncology, National Medical Centre for Oncology, in 2017–2019. Endogenous intoxication was evaluated in all patients depending on the leukogram results: leukocytic int

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13

Sidel’nikova, V. I., A. E. Chernitskiy, and M. I. Retsky. "ENDOGENOUS INTOXICATION AND INFLAMMATION: REACTION SEQUENCE AND INFORMATIVITY OF THE MARKERS (review)." Sel'skokhozyaistvennaya Biologiya 50, no. 2 (2015): 152–61. http://dx.doi.org/10.15389/agrobiology.2015.2.152eng.

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Zimnikov, V. I. "THE SYSTEM OF LIPID PEROXIDATION AND ANTIOXIDANT DEFENSE IN CLINICALLY HEALTHY COWS AND COWS WITH MASTITIS." Transactions of the educational establishment “Vitebsk the Order of “the Badge of Honor” State Academy of Veterinary Medicine 59, no. 1 (2023): 14–17. http://dx.doi.org/10.52368/2078-0109-2023-59-1-14-17.

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Reactive oxygen species (ROS) and the nitric oxide system in most cases are involved in the body of sick animals as a means of combating microorganisms. Some scientists attribute the increase in cytokines to high levels of markers of oxidative stress and nitric oxide. The article presents the results of studying the LPO-AOD system of clinically healthy cows and cows with subclinical and clinically pronounced catarrhal mastitis. It was found that in cows with clinically pronounced catarrhal mastitis deeper disorders in the LPO-AOD system were revealed. This .was expressed by a further depletion

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15

Babinets, L. S., O. S. Zemlyak та I. M. Halabitska. "Endotoxicosis and inflammation as predictors of the deepening of panсreatic functional insufficiency in chronic pancreatitis in combination with type 2 diabetes." Shidnoevropejskij zurnal vnutrisnoi ta simejnoi medicini 2023, № 2 (2023): 37–45. http://dx.doi.org/10.15407/internalmed2023.02.037.

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According to scientists, a significant role in the progression of chronic pancreatitis (CP) and diabetes mellitus (DM), as well as in the occurrence of complications of these diseases, is played by inflammation and endogenous intoxication by the products of protein breakdown as a result of the inflammatory process, fibrosis, and degradation of connective tissue in the patient’s body, in particular, and in the pancreas. The aim is to analyze the state of parameters of inflammation, endotoxicosis, and their influence on the functional capacity of the pancreas in the comorbid course of chronic pa

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Girin, S. V., K. A. Skoryk, and K. Yu Palishnyuk. "Contemporary approaches to assessment of the body's condition of dogs with gastrointestinal pathologies based on the intensity of the inflammato-ry process and the level of endogenous intoxication." Ukrainian Journal of Veterinary and Agricultural Sciences 4, no. 1 (2021): 45–50. http://dx.doi.org/10.32718/ujvas4-1.09.

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Due to the existing methods of diagnosing diseases of domestic animals are ineffective and imperfect, our goal was to develop a technology for assessing the state of the body of dogs to be able to diagnose the occurrence of diseases at an early stage. The article provides data on the development of technology to assess the state of the body, as well as to check its functioning in practice by determining the presence of such typical pathological processes (TPP) as inflammation and endogenous intoxication of the German Shepherd dogs. Clinical, laboratory, and statistical methods were used for th

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17

Demkovych, Andrii. "Endogenous intoxication in development of experimental periodontitis of bacterial-immune genesis." Folia Medica 65, no. 1 (2023): 149–54. http://dx.doi.org/10.3897/folmed.65.e71970.

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Introduction: Excessive lipoperoxidation is accompanied by accumulation of peroxidation products and depletion of antioxidant re-serves, which cause hyperenzymemia and the accumulation of toxic substances. The level of endotoxicosis is determined by the content of hydrophilic and hydrophobic products in the blood.&nbsp; Aim: To define the pathogenetic role of endogenous intoxication in the dynamics of development of experimental periodontitis of bacterial-immune genesis.&nbsp; Materials and methods: The experiment was conducted on rats. The animals were divided into three groups: group

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18

Strilchuk, Larysa M., and Marta O. Kondratyuk. "ENDOGENOUS INTOXICATION SYNDROME ACTIVITY IN BILIARY AUTONOMIC VISCERO-VISCERAL CARDIONEUROPATHY." Eastern Ukrainian Medical Journal 9, no. 2 (2021): 151–56. http://dx.doi.org/10.21272/eumj.2021;9(2):151-156.

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Toxic excess of biologically active substances named middle molecules (MM), which include byproducts of normal and altered metabolism, products of inflammation and oxidation, bacterial remnants, antibodies and immunoactive substances, plays an important role in pathogenesis of gallbladder diseases and biliary autonomous viscero-visceral cardioneuropathy (BAVVCNP). In order to assess activity of the endogenous intoxication syndrome secondary to BAVVCNP, we examined 20 patients with coronary heart disease to determine the levels of MM in the blood (total and at 238, 254, 266, and 280 nm waves);

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Dei, A. A., B. I. Geltser, M. V. Antonyuk, T. A. Gvozdenko, E. P. Kalinina, and I. N. Titorenco. "Assessing the relationship of respiratory muscle strength and cytokine status in patients with community-acquired pneumonia." PULMONOLOGIYA 31, no. 3 (2021): 311–19. http://dx.doi.org/10.18093/0869-0189-2021-31-3-311-319.

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Aim. Assessment of the role of cytokine-mediated changes in the development of respiratory muscle (RM) dysfunction in patients with community-acquired pneumonia (СAP). Methods. 84 men aged 18 – 26 years with a median of age 19.5 [18.4; 22.8]. Mild to moderate CAP (MCAP) was diagnosed in 62 (73.8%) patients and severe (SCAP) in 22 (26.2%). The expiratory (MEP, MRPDout) and inspiratory (MIP, MRPDin. SNIP) strength indices of RM were recorded on a MicrоRPM apparatus (CareFusion, UK). The severity of endogenous intoxication was verified using the following indices: hematologic (HII), leukocyte (LI

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Prokofyeva, T. V., O. A. Bashkina, O. S. Polunina, I. V. Sevostyanova, and E. L. Gritsenko. "Clinical and biochemical phenotypes in cardiorespiratory comorbidity." Medical Herald of the South of Russia 14, no. 2 (2023): 67–75. http://dx.doi.org/10.21886/2219-8075-2023-14-2-67-75.

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Objective: to estimate the incidence of recurrent myocardial infarction, stroke, and mortality in patients with different phenotypes of myocardial infarction against the background of chronic obstructive pulmonary disease. Materials and methods: 325 patients with myocardial infarction were examined: 195 patients with infarction against the background of chronic obstructive pulmonary disease and 130 patients without chronic obstructive pulmonary disease. We studied markers of endogenous intoxication: molecules of average mass, hematological indexes of intoxication, blood gas composition, apopto

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Керменбаева, А. Ж., Н. Дж. Шоонаева, and М. Т. Молдоканова. "Endogenous Intoxication and Formation of Micronuclei in Cells in Pelvic Adhesion in Women." Репродуктивное здоровье. Восточная Европа, no. 3 (July 13, 2023): 237–42. http://dx.doi.org/10.34883/pi.2023.13.3.004.

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В работе представлены данные оценки эндогенной интоксикации и формирования микроядер в клетках у женщин репродуктивного возраста при развитии спаечного процесса в малом тазу. Показано, что развитие эндогенной интоксикации обусловлено деградацией белков, накоплением в плазме крови среднемолекулярных пептидов и активацией фосфолипазы, а также увеличением количества клеток с микроядрами в буккальном эпителии, отражающим стадию спаечного процесса и генетическую предрасположенность части женщин к образованию спаек при воспалении и оперативных вмешательствах на органах малого таза. The paper present

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22

Zasorin, A. A., O. L. Andreeva, N. P. Makarova, and P. P. Konovalov. "Assessment of biochemical parameters of blood serum in patients with chronic pyo-inflammatory diseases of the lower extremities." Kazan medical journal 93, no. 2 (2012): 360–62. http://dx.doi.org/10.17816/kmj2335.

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Aim. To assess the dynamics of wound healing process based on the biochemical parameters of blood serum in patients with phlegmons of the lower extremities treated with various methods of ozone therapy. Methods. Conducted was dynamic monitoring of the biochemical parameters in patients with pyo-inflammatory diseases of the lower extremities. Depending on the method of treatment the patients were divided into three study groups and a control group, 29 people in each. The first group consisted of patients in whon in combination with traditional treatment local ozone therapy was performed. The se

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Zemlyak, Olexandr S., Liliya S. Babinets, and Iryna M. Halabitska. "THE ROLE OF ENDOTOXICOSIS AND INFLAMMATION IN DEEPENING THE PANCREATIC FUNCTIONAL INSUFFICIENCY IN CHRONIC PANCREATITIS IN COMBINATION WITH TYPE 2 DIABETES." Polski Merkuriusz Lekarski 51, no. 3 (2023): 207–15. http://dx.doi.org/10.36740/merkur202303104.

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Aim: To analyze the state of parameters of inflammation, endotoxicosis, and their influence on the functional capacity of the pancreas in the comorbid course of chronic pancreatitis and type 2 diabetes mellitus (DM2). Materials and methods: 115 patients with CP in the phase of mild therapeutic exacerbation in combination with DM2 in the stage of subcompensation were examined. To assess the impact of comorbid DM2 on the clinical condition of patients with CP, a comparison group of 25 patients with CP in the exacerbation phase was included in the study. The assessment of the presence and depth o

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Streltov, Liuba, Valentin Gudumac, and Gheorghe Rojnoveanu. "Endogenous hepatic toxicity and oxidative stress in the complications of gallstones associated with cholestatic jaundice." Moldovan Journal of Health Sciences, no. 4 (December 2023): 3–10. http://dx.doi.org/10.52645/mjhs.2023.4.01.

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Introduction. Cholestatic jaundice installed in gallstones is considered a multifactorial pathogenetic process. The correlation of endogenous hepatic intoxication with the reaction of the pro- and antioxidant system, characteristic of various complications of gallstones associated with cholestatic jaundice, remains an undefined subject. Material and methods. The study included the investigation of 105 patients with complicated gallstones and associated cholestatic jaundice, and the control group – 35 patients with uncomplicated gallstones. The age of the patients varied between 51 and 72 years

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Sumtsova, Kateryna, Vladyslav Berezhok, Anastasiia Lishnevska, and Mykola Chemych. "THE DEPENDENCE OF CHANGES IN LABORATORY INDICATORS ON ACCOMPANYING PATHOLOGY IN PATIENTS WITH VIRAL HEPATITIS C." Eastern Ukrainian Medical Journal 12, no. 1 (2024): 69–80. http://dx.doi.org/10.21272/eumj.2024;12(1):69-80.

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Objective: to determine the dependence of changes in hematological, biochemical indicators and indexes of nonspecific reactivity, inflammation, endogenous intoxication on accompanying pathology in patients with chronic viral hepatitis C (HCV). Materials and methods: hematological, biochemical, non-specific immunological changes were analyzed in 20 chronic HCV patients without cardiovascular system pathologies, in 20 chronic HCV patients with concomitant coronary heart disease (CHD), in 20 people with coronary heart disease and arterial hypertension, and in 40 healthy people. Statistical analys

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Kozhokina, S. G. "The possibility of reversibility of liver fibrosis under the influence of complex treatment." Russian Osteopathic Journal, no. 4 (December 31, 2023): 68–77. http://dx.doi.org/10.32885/2220-0975-2023-4-68-77.

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Endogenous intoxication is a pathological process that develops with the predominance of the formation or intake of toxins over their excretion. Pathological changes occur in the organs of excretion: in the liver, kidneys, lungs, gastrointestinal organs, on the skin. Chronic intoxication leads to chronic inflammation and fibrosis of target organs, i. e. to a violation of the architectonics of connective tissue. Until recently fibrosis was considered as an irreversible process, and it reduced the interest to its early diagnosis. Currently, there is an opinion that fibrosis is potentially revers

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Shakhov, Alexey G., Larisa Yu Sashnina, Julia Y. Vladimirova, Maria Y. Jeines, and Anatoly Y. Samuilenko. "The pathogenetic aspects of acute intestinal infections of suckling piglets." BIO Web of Conferences 17 (2020): 00104. http://dx.doi.org/10.1051/bioconf/20201700104.

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According to the studies piglets with intestinal infections compared to the clinically healthy animals, have lower the content of total protein, gamma globulins and general immunoglobulins, higher levels of malondialdehyde and endogenous intoxication, low molecular weight circulating immune complexes, lysozyme and complementary blood serum activity, phagocytic activity of neutrophils, their absorption and metabolic ability with a low functional reserve of phagocytes. The revealed changes in the biochemical, antioxidant, and immune status should be considered one of the pathogenetic mechanisms

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Radzikhovskyi, M., V. Nedosekov, O. Dyshkant, I. Sokulsky, A. Antoniuk, and M. Rusinko. "Integrated indices as a criterion for evaluation of the level of endogenous intoxication for leptospirosis in dogs." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 23, no. 104 (2021): 77–83. http://dx.doi.org/10.32718/nvlvet10413.

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One of the most important directions in the development of modern veterinary medicine is the improvement and implementation of modern methods of diagnosis and prognosis of diseases based on determining the degree of dysfunction and the possibility of correcting the protective functions of the body. for most veterinary clinics, the study of the immunological status of animals is not available, and clinical blood tests make it possible to determine the assessment of the functional state of the immune system by integrated hematological parameters. In the article on the basis of blood formulas tha

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Vostroilova, G. A., P. A. Parshin, M. S. Zhukov, N. A. Khokhlova, D. I. Shabanov, and A. A. Korchagina. "The state of the prooxidant-antioxidant system in cows with different clinical conditions during pregnancy." International Journal of Veterinary Medicine, no. 2 (June 29, 2023): 301–11. http://dx.doi.org/10.52419/issn2072-2419.2023.2.301.

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The purpose of the research was to study the effect of gestational age on the state of the enzymatic link of antioxidant protection (AOP) of lipid peroxidation products (LPO) in cows with anemia syndrome and chronic systemic inflammation. Three (3) groups of cows were formed: group I (n=15) – healthy; group II (n=8) – with hypochromic microcytic anemia; group III (n=7) – with chronic systemic inflammation syndrome of low intensity. On days 150-160, 210-220 and 260-265 of gestation, blood samples were taken to study the indicators of LPO, AOP and endogenous intoxication. There were obtained the

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Berezhansky, P. V. "Modern enterosorbents in pediatric practice: new therapy possibilities." Russian Journal of Woman and Child Health 8, no. 1 (2025): 72–78. https://doi.org/10.32364/2618-8430-2025-8-1-11.

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Enterosorbents are one of the most commonly used groups of drugs in pediatric practice with sorption and detoxification properties. The efficacy of this group of drugs is due to the ability of enterosorbents not to break down in the gastrointestinal tract, to bind and remove exogenous and endogenous substances, various metabolic products, microorganisms and their toxins from the body, which allows them to be used in various nosologies. The article presents current data on enterosorbents, their classification by dosage form and field of application, and provides examples of pathogenetic activit

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Rudenko, Pavel A., Yuriy A. Vatnikov, Alexander V. Tkachev, et al. "The role of lipid peroxidation products and antioxidant enzymes in the pathogenesis of acute abomasoenteritis in calves." Veterinariya, Zootekhniya i Biotekhnologiya 1, no. 133 (2025): 22–32. https://doi.org/10.36871/vet.zoo.bio.202501104.

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The processes of lipid peroxidation (POL) form the basis of damage to cell membranes. The antioxidant system (AOS) is a multicomponent system for regulating oxygen activation processes, without which the normal functioning of the body would be impossible. The state of the body and the physiological course of vital processes depend on the balance and stability between the POL–AOS systems. The imbalance between these systems determines the clinical manifestation, progression, severity, and prognosis of any inflammatory process in the body. The aim of the work was to determine the state of lipid

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Sultanov, D. D., O. Nematzoda, A. Sh Shokhsavorbekov, R. K. Davlatov, H. A. Yunusov, and S. G. Ali-Zade. "Endogenous intoxication, oxidative stress and antioxidant system in acute lower limb ischemia." Health care of Tajikistan, no. 4 (February 18, 2023): 91–100. http://dx.doi.org/10.52888/0514-2515-2022-355-4-91-100.

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Aim. To study features of endogenous intoxication syndrome (EI), oxidative stress (LPO) and antioxidant defence (AOS) in patients with acute lower limb ischemia (LLI).Materials and methods. Some parameters of EI, LPO and AOS were studied. EI syndrome was studied in 86 patients with LLI who underwent complex examination and treatment in 2020-2021 in the Department of Vascular Surgery of the RNCfCS. POL and AOS parameters were studied in 14 patients out of 86. There were 51 (59.3%) men and 35 (40.7%) women, mean age was 56.0±5.8 years. Acute occlusion of the iliofemoral segments was noted in 33

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Беков, Т. А., Ю. К. Уметалиев, and А. О. Атыканов. "Evaluation of Oxidative Stress and Endogenous Intoxication in Modeling Destructive Cholecystitis in an Animal Experiment." Хирургия. Восточная Европа 12, no. 4 (2023): 389–96. http://dx.doi.org/10.34883/pi.2023.12.4.029.

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Введение. В биологических жидкостях и тканях организма в избыточных концентрациях накапливаются промежуточные и конечные продукты нормального и нарушенного обмена веществ, которые оказывают токсическое влияние и вызывают дисфункцию органов и систем. Цель. Оценка окислительного стресса и эндогенной интоксикации у животных при моделировании деструктивного холецистита. Материалы и методы. Экспериментальное моделирование деструктивного холецистита на 12 кроликов породы шиншилла обоих полов весом 3–4 кг. Материалами для проведения исследований явились плазма крови и мембраны эритроцитов. Результаты

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Dyndar, O. A., and O. Z. Dymarska. "Women of reproductive age endogenous intoxication level assessment after surgical treatment of endometriosis." UKRAINIAN JOURNAL HEALTH OF WOMAN, no. 4(173) (September 28, 2024): 15–20. http://dx.doi.org/10.15574/hw.2024.4(173).1520.

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Endometriosis develops and progresses under conditions of initial endogenous intoxication (EI) and negative changes in the body's reactivity. Surgical treatment is accompanied by tissue destruction at the site of trauma, aseptic inflammation, pathological protein catabolism, and massive cell death, which may lead to the development of a syndrome of mutual aggravation. Aim - to determine the level of EI in women of reproductive age with endometriomas, depending on the surgical treatment method. Materials and methods. A laparoscopic surgical treatment was performed on 120 reproductive-aged patie

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Boriskina, O. L., V. N. Tsigan, A. S. Rumyantsev, and A. A. Yakovenko. "The role of advanced glycation end products in sarcopenia in CKD patients." Nephrology (Saint-Petersburg) 27, no. 4 (2023): 43–51. http://dx.doi.org/10.36485/1561-6274-2023-27-4-43-51.

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The accumulation of glycation end products (AGEs) is closely related to chronic inflammation, oxidative stress and can affect muscle function. An increase of the concentration of AGEs in the serum can be observed in patients already at the initial stages of the formation of chronic kidney disease (CKD). At the same time, there is no need for a violation of carbohydrate tolerance or diabetes mellitus. Sarcopenia is one of the complications of CKD. Its development in CKD can be considered not only as a result of endogenous intoxication, but also as one of the variants of premature aging. This li

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Nahaichuk, V. I., H. P. Kozynets, V. Kh Sharipova, О. Chirimpey, and B. Tuleubaev. "The first results of the international multicenter clinical study RheoSTAT-CP0669 on the effectiveness and safety of infusion solution Rheosorbilact® in the complex treatment of patients with burns." Infusion & Chemotherapy, no. 4 (December 21, 2023): 5–12. http://dx.doi.org/10.32902/2663-0338-2023-4-5-12.

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Mechanization and urbanization are accompanied by an increase in the prevalence of burns. A burn causes both local damage and systemic inflammatory response that leads to inadequate oxygen delivery to vital organs and inadequate elimination of metabolites. Infusion therapy for burns aims to restore perfusion and prevent ischemia. The implementation of effective dynamic schemes of infusion therapy has led to a decrease in mortality, however, an excessive amount of injected fluid does not improve the patient’s volumetric status, instead increasing tissue swelling and causing a number of complica

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Serenko, Аnton A., Vasyl H. Hroma, Dmytro V. Minukhin, et al. "TREATMENT EXPERIENCE OF CHRONIC LUNG ABSCESSES USING MINI-INVASIVE ELECTROSURGICAL TECHNIQUES." Wiadomości Lekarskie 76, no. 10 (2023): 2277–82. http://dx.doi.org/10.36740/wlek202310122.

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The aim: To increase the efficiency of surgical treatment of patients with chronic lung abscesses by developing mini-invasive methods of surgical treatment using electrosurgical technologies. Materials and methods: Conducted study of the results of surgical treatment of 78 patients with chronic lung abscesses operated from 2011 to 2021. Patients were divided into two groups: the main group (37 patients who were treated using developed technologies) and a comparison group (41 patients, treated using traditional tactics). Results: Transthoracic and endobronchial sanitation of the purulent cavity

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Dudka, I. V., and O. S. Khukhlina. "Effectiveness of using of ethylmethylhydroxypyridine succinate in complex treatment of exacerbation of chronic pancreatitis with chronic obstructive pulmonary disease." Ukrainian Therapeutical Journal, no. 2 (June 19, 2025): 25–32. https://doi.org/10.30978/utj2025-2-25.

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In the conditions of comorbidity of chronic pancreatitis (CP) and chronic obstructive pulmonary disease (COPD), a number of pathogenetic components of mutual burden of exacerbation of both diseases have been established, namely: chronic hypoxia caused by COPD, intensification of oxidative and nitrosative stress against the background of significant depletion of the antioxidant defense system, endogenous intoxication, activation of systemic inflammation and proteolysis. In recent years, the use of drugs with antihypoxic and antioxidant effects has been studied, which would allow preventing and

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Komarytsia, O. Y., M. O. Kondratyuk, and O. M. Radchenko. "Specific indicators of endogenous intoxication syndrome under the conditions of concomitant steatosis of the liver." Клінічна та профілактична медицина 2, no. 24 (2023): 20–25. http://dx.doi.org/10.31612/2616-4868.2(24).2023.03.

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The basic aspects of the endogenous intoxication syndrome (EIS) in the pathogenesis of many diseases are still poorly understood - an increase in the content of a wide variety of compounds, most of which belong to middle mass molecules (MMM) with a mass of 500-2000 D, the content of which under the conditions of metabolically associated steatosis of the liver (MASL) as the initial stage of the fatty disease has not been yet established. In order to determine the content of molecules of average mass of total and their fractions in the blood and urine in patients with MASL, 25 patients wer

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Komarytsia, O. Y., L. I. Pylypiv, and O. M. Radchenko. "Peculiarities of Metabolism and Cardiac Electrical Activity in Patients with Chronic Obstructive Pulmonary Disease and Coronary Heart Disease in the Presence of Metabolically-Associated Liver Steatosis." Tuberculosis, Lung Diseases, HIV Infection, no. 4 (November 30, 2023): 10–15. http://dx.doi.org/10.30978/tb2023-4-10.

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While the development of specific steatohepatitis-associated cardiomyopathy (SHACMP) in the context of fatty liver disease has been documented, it remains unclear whether any cardiac changes occur during the initial stage of fatty liver disease, known as metabolic-associated liver steatosis (LS). Objective — to evaluate the characteristics of metabolism and electrical activity of the heart in patients with chronic obstructive pulmonary disease and chronic forms of coronary heart disease and concomitant liver steatosis. Materials and methods. 35 patients with chronic obstructive pulmonary disea

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Kovalenko, O. M., O. I. Osadcha, A. A. Kovalenko, A. S. Grisha, O. M. Lynnyk, and N. G. Belinska. "Fluid resuscitation patients with burn sepsis." Infusion & Chemotherapy, no. 3.1 (October 11, 2020): 42–43. http://dx.doi.org/10.32902/2663-0338-2020-3.1-34.

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Objective. The purpose the of the study is to improve the fluid therapy regimens for burn sepsis patient. Materials and methods. The study is based on the observation 52 patients with burn sepsis aged 23 to 65 years, with a total body surface area more than 35 % at the Kyiv City Clinical Hospital № 2 during 2016-2019. Patients were divided into two groups: the main group – 30 patients were treated with crystalloids, plasma, albumin and Rheosorbilact (RSL); control group – 16 patients received treatment without using of RSL. Clinical and biochemical parameters of endogenous intoxication (

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Hrek, Ivan, Maryna Kochuieva, Valentyna Psarova, Hennady Kochuiev, and Anton Rohozhyn. "THE EFFECT OF ANTIOXIDANT THERAPY ON THE CHANGES OF CLINICAL AND LABORATORY PARAMETERS IN ALCOHOL DRINKERS WITH PULMONARY TUBERCULOSIS." Eastern Ukrainian Medical Journal 10, no. 3 (2022): 259–67. http://dx.doi.org/10.21272/eumj.2022;10(3):259-267.

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Objective. Determination of the effect of antioxidants on clinical and laboratory parameters in alcohol drinkers with infiltrative newly-diagnosed pulmonary tuberculosis (PTB). Materials and Methods. 109 patients with newly-diagnosed PTB were examined. All patients underwent a comprehensive medical examination, immunological blood tests, determination of the parameters of the oxidative stress-antioxidant defense system. Patients were divided into three main groups, depending on the level of alcohol consumption. Patients in each of the three groups were further divided into two subgroups depend

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Mihm, Sabine. "Danger-Associated Molecular Patterns (DAMPs): Molecular Triggers for Sterile Inflammation in the Liver." International Journal of Molecular Sciences 19, no. 10 (2018): 3104. http://dx.doi.org/10.3390/ijms19103104.

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Inflammatory liver diseases in the absence of pathogens such as intoxication by xenobiotics, cholestatic liver injury, hepatic ischemia-reperfusion injury (I/R), non-alcoholic steatohepatitis (NASH), or alcoholic liver disease (ALD) remain threatening conditions demanding specific therapeutic options. Caused by various different noxae, all these conditions have been recognized to be triggered by danger- or death-associated molecular patterns (DAMPs), discompartmentalized self-structures released by dying cells. These endogenous, ectopic molecules comprise proteins, nucleic acids, adenosine tri

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Di Paola, Rosanna, Sergio Modafferi, Rosalba Siracusa, et al. "S-Acetyl-Glutathione Attenuates Carbon Tetrachloride-Induced Liver Injury by Modulating Oxidative Imbalance and Inflammation." International Journal of Molecular Sciences 23, no. 8 (2022): 4429. http://dx.doi.org/10.3390/ijms23084429.

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Liver fibrosis, depending on the stage of the disease, could lead to organ dysfunction and cirrhosis, and no effective treatment is actually available. Emergent proof supports a link between oxidative stress, liver fibrogenesis and mitochondrial dysfunction as molecular bases of the pathology. A valid approach to protect against the disease would be to replenish the endogenous antioxidants; thus, we investigated the protective mechanisms of the S-acetyl-glutathione (SAG), a glutathione (GSH) prodrug. Preliminary in vitro analyses were conducted on primary hepatic cells. SAG pre-treatment signi

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Feshchenko, Y. I., S. Beridze, Dinh Thi Hoa, et al. "The first data on international multicenter clinical study RheoSTAT-CP0698 on the efficacy and safety of Rheosorbilact® infusion in therapy of pneumonia." Infusion & Chemotherapy, no. 1 (March 25, 2021): 5–14. http://dx.doi.org/10.32902/2663-0338-2021-1-5-14.

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ABSTRACT. Adequate and effective treatment of severe pneumonia is especially relevant in present situation. The most problematic issue is infusion therapy. The current evidence and guidelines recommend balanced crystalloid infusion for patients with severe pneumonia and sepsis. The composition of Rheosorbilact® provides significant benefits in patients with severe infections, including respiratory infections. According to the results of the randomized open blinded end-point RheoSTAT-CP0698 study, administration of Rheosorbilact® to patients with pneumonia (intravenous infusion at a dose of 200

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Chemych, Mykola D., Dmytro S. Sosnovenko, Oksana M. Chemych, and Oleh B. Berest. "HEMATOLOGICAL CHANGES OF ENDOGENIC INTOXICATION, NON-SPECIFIC REACTIVITY AND INFLAMMATION ACTIVITY INDICES IN HIV-INFECTED PATIENTS." Wiadomości Lekarskie 73, no. 5 (2020): 983–87. http://dx.doi.org/10.36740/wlek202005127.

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The aim: To establish changes in hematological parameters of endogenous intoxication, nonspecific reactivity, activity of inflammation in HIV-infected persons, to improve verification of the clinical stage of the disease. Materials and methods: Anamnestic, clinical, laboratory data. The statistical processing was performed in the Microsoft Office Excel 2010 and IBM SPSS Statistic 23 computer software, variational statistics processing (Student’s t-criteria). Results: 51 HIV-infected were examined (main group) and 44 clinically anamnestic healthy blood donors (comparison group). The study inclu

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Lanicheva, Al'bina Khamitovna, Renata Ruslanovna Valeeva, and Valeriy Vasil'evich Semchenko. "IMMUNOHISTOCHEMICAL VERIFICATION OF P53 AND BCL-2 EXPRESSION IN RAT LIVER HEPATOCYTES AFTER MECHANICAL THIGH INJURY." Ulyanovsk Medico-biological Journal, no. 2 (June 30, 2025): 141–49. https://doi.org/10.34014/2227-1848-2025-2-141-149.

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Mechanical impacts on a limb segment can lead to metabolic disorders in the affected organs and tissues, resulting in the development of endogenous intoxication and circulatory-hypoxic damage. The liver is one of the first to react to the dyscrasia caused by intoxication, due to an increase in the concentration of inflammation mediators and cytokines after mechanical limb injuries or burns. The aim of the study is to determine the dynamics of bcl-2 and p53 expression in rat liver hepatocytes after mechanical thigh injury. Materials and Methods. The study was performed on white male rats weighi

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Strilchuk, L. M., and A. L. Filipyuk. "Clinical aspects of usage of neutrophil-to-lymphocyte ratio in cardiology: literature review and own data." Experimental and Clinical Medicine 87, no. 2 (2020): 27–35. http://dx.doi.org/10.35339/ekm.2020.87.02.04.

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We analyzed the data of 197 patients with IHD, unstable (116) and stable (81) angina pectoris, and also prospective data 121 patient with chronic IHD (3 years of follow-up). We included 20 healthy volunteers for reference values. Digital data was statistically processed. According to literature data, NLR can serve as a prognostic marker of cardiovascular disease course. Its level depends on nosology; its increase is an independent predictor of IHD, higher mortality level, repeated inpatient treatment, atrial fibrillation, insufficient efficiency of invasive cardiologic procedures. NLR also cor

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Radsikhovskii, M., L. Goralskii, B. Borissevich, and O. Dyshkant. "Integral indexes of intoxication in caninae coronaviridae enteritis." Naukovij vìsnik veterinarnoï medicini, no. 2 (144) (December 24, 2018): 13–19. http://dx.doi.org/10.33245/2310-4902-2018-144-2-13-19.

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In this article to be spoken about indicators of action of coronaviridae on an organism of animals – qualitative and quan-titative characteristics of blood. These indicators change at many patological reactions and participate in ensuring nonspe-cific and specific resistance of an organism. With the help of the analysis of integral leukocyte indices based on the formula of blood reflecting the state of neurohumoral homeostasis and immunological reactivity of the organism, the violations were first discovered and established humoral and cellular links of the immune system, micro- and macrophage

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Radchenko, O. M., O. J. Komarytsia, M. O. Borovets, R. S. Ivasivka, and R. R. Guta. "Proinflammatory interleukins 2, 6 and tumor necrosis factor alpha in patients with hypertension and diabetes mellitus depending on the presence of metabolic-associated liver steatosis." INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) 20, no. 3 (2024): 200–203. http://dx.doi.org/10.22141/2224-0721.20.3.2024.1389.

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Background. Lack of information about proinflammatory interleukins (IL) and tumor necrosis factor alpha (TNFα) levels in case of metabolic-associated liver steatosis (MALS) and their roles in its progression to steatohepatitis are key reasons for the relevance and actuality of our study. The purpose: to evaluate proinflammatory interleukins 2, 6, and TNFα levels in concomitant liver steatosis. Materials and methods. Thirty-five patients with hypertension stage II–III, type 2 diabetes mellitus were examined. All of them were treated on an outpatient basis according to the guidelines of the Mini

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