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Dissertations / Theses on the topic 'Inflammation and metabolic syndrome'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Aghilla, Mohamed M. "Inflammation and cardio-metabolic risks in polycystic ovary syndrome." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/50038/.

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Polycystic Ovary Syndrome (PCOS) is the most common reproductive and endocrine disorder in females during their reproductive life. The syndrome is characterized by a constellation of symptoms and signs including menstrual disturbance, hyperandrogenism and polycystic ovaries. Other features of PCOS include obesity, metabolic syndrome, insulin resistance and an increased risk of developing diabetes mellitus and cardiovascular disease. Recently, PCOS has been recognized as a low grade inflammatory condition. Several inflammatory markers have been found to be raised in PCOS, such as interleukin-6,

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2

MacDonald, Marcia Leigh. "Stearoyl-CoA desaturase : role in metabolic syndrome, atherosclerosis and inflammation." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/24653.

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Combination of the risk factors obesity, insulin resistance, dyslipidemia, and hypertension, often described as the "metabolic syndrome," increases the risk of developing diabetes and cardiovascular disease. Stearoyl-coenzyme A desaturase (SCD) activity has been implicated in the metabolic syndrome; however, earlier studies on the beneficial metabolic effects of SCD1 deficiency have been confined to normolipidemic mice, and the role of SCD in the context of atherosclerosis has not been examined. The primary purpose of this thesis was to investigate the effect of decreased SCD activity on susc

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3

Mohammed, Nadeem K. "DIET, BACTERIA AND INFLAMMATION: THE INTESTINAL MUCOSA AND METABOLIC SYNDROME." UKnowledge, 2012. http://uknowledge.uky.edu/nutrisci_etds/4.

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Long term consumption of a high fat diet (HFD) increases the risk of developing Metabolic Syndrome and type 2 diabetes. This led us to hypothesize that long term HFD consumption impairs immune tolerance to the intestinal bacteria. Our studies had two goals. First, we characterized the effect of long term HFD consumption on the systemic immune response by comparing C57BL6 mice fed a HFD and low fat diet (LFD). Plasma immunoglobulin G (IgG) against Escherichia coli (LF-82), E. coli (Nissle 1917), Bacteroides thetaiotaomicron and Lactobacillus acidophilus were measured by a lab-developed ELISA. F

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4

Kyrou, Ioannis. "Impact of obesity and metabolic syndrome on morbidity, inflammation and adipokines." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/55046/.

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5

Moncrieft, Ashley E. "Inactivity, Inflammation, and Insulin Resistance in Type 2 Diabetes and the Metabolic Syndrome." Scholarly Repository, 2011. http://scholarlyrepository.miami.edu/oa_theses/300.

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Both type 2 diabetes (T2D) and the the metabolic syndrome (MetS) have been shown to increase the risk of cardiovascular disease (CVD). Inflammation and insulin resistance have each been associated with the development of MetS and the onset of T2D as well as the risk of CVD. Inflammation and insulin resistance are therefore suitable targets for public health initiatives and interventions in persons at risk for or living with CVD. Physical inactivity is a major risk factor for CVD as well as MetS and T2D. Conversely, increased physical activity is associated with improved health outcomes for in

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6

Lao, Xiangqian, and 勞向前. "Inflammation, metabolic syndrome and vascular diseases in older Chinese: the Guangzhou biobank cohortstudy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40687685.

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7

Fleming, Belinda J. "Metabolic syndrome, inflammation, heart rate variability, and fitness in obese African American Youth." View the abstract Download the full-text PDF version, 2009. http://etd.utmem.edu/ABSTRACTS/2009-026-Fleming-index.htm.

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Thesis (Ph.D.)--University of Tennessee Health Science Center, 2009.<br>Title from title page screen (viewed on August 6, 2009). Research advisor: Patricia A. Cowan, Ph.D. Document formatted into pages (xii,112p. : ill.). Vita. Abstract. Includes bibliographical references (p. 83-111).

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Lao, Xiangqian. "Inflammation, metabolic syndrome and vascular diseases in older Chinese the Guangzhou biobank cohort study /." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B40687685.

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9

Natanzon, Yanina. "METABOLIC SYNDROME IN AN IMMUNOSUPPRESSED POPULATION: GENETIC CONTRIBUTION TO METABOLIC SYNDROME TRAITS IN THE WOMEN'S INTERAGENCY HIV STUDY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1449252475.

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10

Tomás, Hernández Sara. "Characterization of the biological effects of natural compounds against inflammation, metabolic syndrome and cancer." Doctoral thesis, Universitat Rovira i Virgili, 2017. http://hdl.handle.net/10803/456815.

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Els productes naturals han sigut àmpliament utilitzats per al tractament i prevenció de moltes malalties. L’objectiu principal d’aquesta tesi ha estat caracteritzar compostos naturals bioactius que podrien ser utilitzats per a la prevenció o tractament d’algunes malalties rellevants com ara la síndrome metabòlica, les malalties neurodegeneratives i el càncer. Aquestes condicions mèdiques representen un problema de salut important ja constitueixen les principals causes de mort a nivell mundial. Atès que nombrosos estudis han demostrat que el procés d’inflamació crònica està directament involu

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Taki, Kentaro, Kazuko Nishio, Nobuyuki Hamajima, and Toshimitsu Niwa. "METABOLIC SYNDROME DEFINED BY NEW CRITERIA IN JAPANESE IS ASSOCIATED WITH INCREASED LIVER ENZYMES AND C-REACTIVE PROTEIN." Nagoya University School of Medicine, 2008. http://hdl.handle.net/2237/9646.

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12

Tomaro-Duchesneau, Catherine. "Microencapsulated ferulic acid esterase active «Lactobacillus fermentum» for the reduction of inflammation and cholesterol in metabolic syndrome." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121276.

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Metabolic syndrome (MetS) is an important public health concern of industrialized countries. MetS is a cluster of metabolic disturbances, including abdominal obesity, atherogenic dyslipidemia, elevated blood pressure, insulin resistance and the presence of a proinflammatory and prothrombotic state. Currently, there is no successful therapeutic intervention for the prevention and treatment of this disorder. Chronic systemic inflammation and hypercholesterolemia are two important therapeutic targets of MetS. The goal of this work is to develop a novel microencapsulated ferulic acid-producing pro

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Cai, Yin, and 蔡寅. "Prostaglandin E receptor subtype 4 and repressor activator protein 1 : independent multifaceted metabolic players." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/209513.

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SPANGARO, MARCO. "COGNITIVE IMPAIRMENT IN SCHIZOPHRENIA: DISENTANGLING THE ROLE OF METABOLIC ALTERATIONS AND NEUROINFLAMMATION." Doctoral thesis, Università Vita-Salute San Raffaele, 2022. http://hdl.handle.net/20.500.11768/133080.

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This study aimed at investigating the relationship between cognition, Metabolic Syndrome and inflammation in a sample of patients with schizophrenia, also investigating in a subsample possible influences of Metabolic Syndrome and related inflammatory biomarkers on white matter integrity and brain metabolites of the Dorsolateral Prefrontal Cortex.<br>Obiettivo di questo studio è l'analisi del rapporto tra deficit cognitivo, Sindrome Metabolica e infiammazione in un campione di pazienti affetti da schizofrenia, analizzando inoltre all'interno di un sottocampione possibili influenze della Sindrom

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Griffin, Laura E. "The Influence of Dietary Flavanol Mean Degrees of Polymerization on Sensory Preference Trends and the Metabolic Syndrome." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/86238.

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According to the Centers for Disease Control, roughly 9.4% of the US population is diabetic, and at least 35% of the US population has metabolic syndrome. These diseases are associated with increased mortality risk, reduced quality of life, and altered taste perception of foods. With increased occurrence of these metabolic diseases, there is a greater need for research oriented towards using lifestyle modifications to combat illness. A relationship between flavanol consumption, health benefits, and taste perception has been well documented. Dietary flavanols are secondary plant metabolites tha

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Davis, Lisa. "The effects of a high walnut and unsalted cashew nut diet on the antioxidant status of subjects with diagnosed metabolic syndrome / Lisa Davis." Thesis, North-West University, 2005. http://hdl.handle.net/10394/987.

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Motivation: Metabolic syndrome is a constellation of risk factors predisposing to coronary heart disease (CHD) and is classified as a "disease of modern civilization". Characteristics of the metabolic syndrome include abdominal obesity, increased triacylglycerol (TG) concentrations, increased small dense low-density lipoprotein(LDL) particles, decreased high-density lipoprotein cholesterol (HDL-C), hypertension, insulin resistance, inflammation, glucose intolerance and/or type 2 diabetes mellitus. Subjects with metabolic syndrome may be susceptible to oxidative stress due to their prolonged e

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DELLA, PORTA MATTEO. "FATTY ACIDS UNSATURATION AND OXIDATIVE STRESS IN MEMBRANE FUNCTION, PREGNANCY, AND METABOLIC SYNDROME." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/824544.

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Fatty acids have biological activities that go far beyond their function as energy sources. A correct the dietary ratio between the nutritionally essential ω‐6 and ω‐3 polyunsaturated fatty acids (PUFA) is fundamental for the physiological production of second messengers, such as eicosanoids and other autacoids, and to ensure a controlled biological response to numerous physiological and pathological processes. Besides, PUFA, because of the unsaturation of their carbon chains, play an important role in maintaining the structure and a correct fluidity state of the membranes, the latter is

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Parker, Benjamin. "Determining the relationship between inflammation, therapeutic exposure and cardiovascular risk in patients with systemic lupus erythematosus." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/determining-the-relationship-between-inflammation-therapeutic-exposure-and-cardiovascular-risk-in-patients-with-systemic-lupus-erythematosus(524e5d0f-f5fa-4750-b1bc-20f1c0cfa4d3).html.

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Introduction: SLE is associated with pro-atherogenic metabolic derangement and an elevated cardiovascular risk. The vascular endothelium may be a key interface between active SLE and premature atherosclerosis. Improved understanding of the contribution of inflammation and its management to cardiovascular risk in SLE will inform personalised treatment decisions in SLE patients. Methods: Data from an international inception cohort was used to investigate the relationship between inflammatory disease activity, lupus phenotype and corticosteroid exposure and the metabolic syndrome (MetS) over 2 ye

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Cline, Jennifer L. "The Relationship Between FAM5C SNP (rs10920501) Variability, Metabolic Syndrome, and Inflammation, in Women with Coronary Heart Disease." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3830.

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The leading cause of death among women is coronary heart disease (CHD), a multifactorial disease with polygenic heritability estimated at 50%. Polymorphisms in the family with sequence similarity 5, member C’ ( FAM5C) gene have been associated with myocardial infarction (MI), and one single-nucleotide polymorphism (SNP) has partially accounted for linkage in an acute coronary syndrome subset. The linkage peak on FAM5C corresponds directly with a quantitative trait locus for the inflammatory biomarker monocyte chemoattractant protein 1, as well as a linkage peak to metabolic syndrome (MetS). Me

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Moullan, Norman. "Identification and validation of a potent synthetic TGR5 agonist that improves metabolism, inflammation and atherosclerosis." Thesis, Paris, EPHE, 2015. http://www.theses.fr/2015EPHE3070.

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L’obésité, le diabète de type 2 et l’athérosclérose sont les principaux problèmes de santé publique affectant les pays développés. Bien que de nombreux traitements soient disponibles contre ces maladies, de nombreux progrès sont encore nécessaire pour le développement de composés plus actif et plus sûr. Mon laboratoire a montré que l’activation du récepteur aux acides biliaires TGR5 par ses ligands entrainait une augmentation de la dépense énergétique et réduisait le niveau des cytokines chez la souris, ce qui pourrait être une nouvelle voie vers le traitement de ces désordres métaboliques. No

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21

May, Aaron. "Hormonal Influence on Insulin Transport Through the Blood-Brain Barrier and Hypothalamic Inflammation." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1479809275921804.

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22

Bolusani, Hemanth. "A randomised, double blind, crossover study of the effects of CLA isomers on inflammation, body composition, metabolic profiles and vascular function in subjects with the metabolic syndrome." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/61649/.

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A variety of individual and population based approaches to prevention and management of obesity are required and there is an increasing interest in functional foods and natriceuticals. Conjugated linoleic acid (CLA) has generated enormous interest in this context due to their ability to modulate PPAR’s and the associated metabolic processes. Aims & methods: This study aimed to investigate the effects of CLA supplementation in a randomised, double blind crossover trial on inflammation, vascular function and metabolic profiles in subjects with the metabolic syndrome. Results: This study utilised

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23

Sun, Antonia Rujia. "Macrophage-mediated synovial inflammation is a key link to obesity-associated osteoarthritis." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/123711/1/Antonia%20Rujia_Sun_Thesis.pdf.

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Obesity has been attributed in a major risk factor for developing and accelerating disease progression in osteoarthritis. To date, there is a lack of clinically proven therapies to halt osteoarthritis, the developments of such therapies are therefore a national as well as an international research priority. This research provides a new overview of the involvement of synovitis in promoting the destruction of synovial joints in obesity-induced osteoarthritis and might therefore by used as a therapeutic strategy for the development of disease-modifying anti-osteoarthritis drugs.

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24

Andersson, Jonas. "Inflammation and lifestyle in cardiovascular medicine." Doctoral thesis, Umeå universitet, Medicin, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-36221.

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Despite major advances in the treatment and prevention of atherosclerosis the last several decades, cardiovascular disease still accounts for the majority of deaths in Sweden. With the population getting older, more obese and with rising numbers of diabetics, the cardiovascular disease burden may increase further in the future. The focus in cardiovascular disease has shifted with time from calcification and narrowing of arteries to the biological processes within the atherosclerotic plaque. C-reactive protein (CRP) has emerged as one of many proteins that reflect a low grade systemic inflammat

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Zeugmann, Sara [Verfasser]. "Inflammation, metabolic syndrome, & early life stress in major depression : an investigation into the mind-body connection of affective disorders / Sara Zeugmann." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://d-nb.info/1071088831/34.

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Harmse, Berna. "Body composition, physical activity and C-reactive protein in children : the PLAY study / B. Harmse." Thesis, North-West University, 2006. http://hdl.handle.net/10394/1353.

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Silva, Jacqueline Cavalcante. "Investigação dos efeitos de novos derivados tiazolidínicos em modelo animal de síndrome metabólica." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-29042015-102947/.

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A síndrome metabólica (SM) é definida como um grupo de condições que aumentam o risco para doenças cardiovasculares e diabetes, com quadro clínico reconhecido por componentes como obesidade abdominal, dislipidemia, hipertensão arterial e resistência à insulina ou intolerância à glicose. Na população de 20 a 70 anos, apresenta prevalência de 24% no Brasil e no mundo. A resistência à insulina e a inflamação são demonstradas como características de grande importância na síndrome metabólica, que constituem alvos interessantes para novas abordagens terapêuticas. Nesse sentido, a classe de fármacos

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Nasralla, Eman Abdulwahhab. "Metabolic syndrome and relation of obesity indices to biomarkers of insulin sensitivity and inflammation among Qatari men and women : the Qatar Biobank Project." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/34919.

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Background: Increased body fatness along with other conditions typical of the metabolic syndrome (MetS) such as insulin resistance have become more prevalent in Qatar due to rapid transitions in the Qatari's population lifestyle in the last few decades. The government of Qatar is seeking to improve the public's health; however, epidemiological studies on Qataris are limited. Aims: This research aims to 1) describe the features of the MetS and its determinants among a sample of Qataris, 2) explore the difference between four obesity subgroups regarding selected factors of metabolic health and 3

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Alexander, Lindsey Ann. "The Role of Inflammation in Diet-Induced Insulin Resistance." University of Toledo / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1260808416.

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Antwi, Janet. "Factors of Inflammation in Haitian Americans and African Americans with and without Type 2 Diabetes." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1587.

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Chronic low-grade inflammation has been implicated in the processes leading to the development of type 2 diabetes (T2D) and its progression. Non-Hispanic Blacks bear a disproportionate burden of T2D and are highly susceptible to inflammation. This cross-sectional study assessed and compared the serum levels of established adipocytokines; interleukin-6 (IL-6), C-reactive protein (CRP), leptin, and novel adipocytokines; chemerin and omentin in Haitian and African Americans with and without T2D. The relationships of these adipocytokines with metabolic syndrome (MetS), anthropometric and HOMA2 mea

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Dayoub, Ousama. "Impact de la delphinidine sur les fonctions de lymphocytes T chez les sujets sains et les patients atteints de syndrome métabolique." Thesis, Angers, 2016. http://www.theses.fr/2016ANGE0051.

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L'obésité et ses complications métaboliques comme le syndrome métabolique (SM) deviennent des épidémies mondiales qui partagent une composante commune qu’est l'inflammation chronique. Les acteurs principaux de cette inflammation sont les lymphocytes T. L’utilisation des polyphénols capables de moduler les fonctions de lymphocytes T pour lutter contre les maladies métaboliques inflammatoires fait l’objet de nombreuses investigations. Dans cette étude, nous avons analysé l'effet de la delphinidine, un anthocyane connu pour préserver l'intégrité de l'endothélium par un mécanisme dépendant au réce

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Zieger, Konstanze, Juliane Weiner, Anne Kunath, et al. "Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high fat diet-induced obesity by counteracting adipose tissue inflammation in vivo." Springer, 2018. https://ul.qucosa.de/id/qucosa%3A33207.

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Vaspin is an adipokine which improves glucose metabolism and insulin sensitivity in obesity. Kallikrein 7 (KLK7) is the first known protease target inhibited by vaspin and a potential target for the treatment of metabolic disorders. Here, we tested the hypothesis that inhibition of KLK7 in adipose tissue may beneficially affect glucose metabolism and adipose tissue function. Therefore, we have inactivated the Klk7 gene in adipose tissue using conditional gene-targeting strategies in mice. Klk7-deficient mice (ATKlk7 −/−) exhibited less weight gain, predominant expansion of subcutaneous adipose

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Rodrigues, Carlos Ewerton Maia. "Adipocitocinas na síndrome antifosfolípide primária: potenciais marcadores de inflamação, resistência insulínica e síndrome metabólica." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5164/tde-17062011-163644/.

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INTRODUÇÃO: Síndrome antifosfolípide está associada com aterosclerose acelerada. Embora adipocitocinas exerçam um papel fundamental na interface entre obesidade, inflamação, resistência insulínica e aterosclerose, a exata natureza e relativa contribuição das adipocitocinas, como potenciais marcadores, requer investigação na síndrome antifosfolípide primária (SAFP). OBJETIVO: Este estudo foi desenvolvido para avaliar a possível associação das adipocitocinas com síndrome metabólica (SM), inflamação e outros fatores de risco cardiovascular na SAFP. MÉTODOS: 56 pacientes com SAFP e 72 controles sa

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Poulain, Laureline. "Syndrome d'apnées obstructives du sommeil et risque cardiovasculaire : rôle du tissu adipeux viscéral dans les troubles métaboliques et l'athérosclérose induits par l'hypoxie intermittente." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENV076/document.

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Le syndrome d'apnées obstructives du sommeil (SAOS) est un problème de santé publique par sa prévalence dans la population générale (5-20%) et ses nombreuses complications métaboliques et cardiovasculaires. La répétition des apnées génère une hypoxie intermittente (HI) considérée comme le facteur principal responsable de cette morbidité cardiovasculaire dont l'athérosclérose. Cependant les mécanismes physiopathologiques sont peu connus. De nombreux arguments évoquent l'implication de la graisse blanche viscérale notamment via la sécrétion de médiateurs inflammatoires. Les objectifs de notre tr

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Timpson, Nicholas John. "Inflammation, insulin resistance and components of the metabolic syndrome : Mendelian randomisation as a tool for the dissection of epidemiological relationships : has the pawn risen too early?" Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443697.

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Rosell, Castillo Alejandro 1977. "Síndrome metabólica em pacientes com Pan-hipopituitarismo : caraterização clínico-laboratorial." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308785.

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Orientadores: Denise Engelbrecht Zantut Wittmann, Heraldo Mendes Garmes<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-27T18:57:15Z (GMT). No. of bitstreams: 1 RosellCastillo_Alejandro_M.pdf: 1638622 bytes, checksum: 1b3c715bebcd9913f573b5ef8758046e (MD5) Previous issue date: 2015<br>Resumo: Introdução O Hipopituitarismo (HP) é uma doença que tem como condição básica a deficiência na produção ou na ação de qualquer um dos hormônios da adeno-hipófise. Quando isto ocorre em dois ou mais hormônios, é denominado

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Sliz, E. (Eeva). "Genetics and molecular epidemiology of metabolic syndrome-related traits:focus on metabolic profiling of lipid-lowering therapies and fatty liver, and the role of genetic factors in inflammatory load." Doctoral thesis, Oulun yliopisto, 2019. http://urn.fi/urn:isbn:9789526222554.

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Abstract Metabolic syndrome is a constellation of metabolic abnormalities predisposing to cardiovascular diseases (CVD), type 2 diabetes, and increased mortality. Due to the high prevalence and severe co-morbidities, metabolic syndrome constitutes a major burden for both public health and the global economy. Improved understanding of the detailed molecular mechanisms could provide novel strategies for the treatment and preferably prevention of the metabolic syndrome-related health issues. Recent advancements in ‘omics’ technologies have facilitated the development of novel tools to examine the

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Miguel, Ana Carolina Moron Gagliardi. "Efeitos da suplementação de manteiga e margarinas no metabolismo lipídico e inflamação de portadores de síndrome metabólica que mantiveram seus hábitos usuais de vida." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-19032010-112343/.

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Introdução: O consumo de manteigas e margarinas faz parte do hábito alimentar da população e é uma forma eficaz de suplementação de ácidos graxos. No entanto, até o momento se desconhece os efeitos de ácidos graxos saturados, trans, monoinsaturados, poliinsaturados e de fitosteróis no perfil lipídico, inflamatório, de marcadores de disfunção endotelial e no metabolismo da HDL em indivíduos com síndrome metabólica (SM). Objetivo: Examinar os efeitos do consumo diário de manteiga, margarina com ácido graxo trans, margarina com fitosterol e margarina sem ácido graxo trans, em quantidades recomend

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Martins, Caroline Curry. "AVALIAÇÃO DOS SISTEMAS PURINÉRGICO E COLINÉRGICO NO PROCESSO INFLAMATÓRIO DE PACIENTES COM SÍNDROME METABÓLICA." Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/11206.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Metabolic syndrome (MetS) is characterized by the presence of set cardiovascular risk factors such as hypertension, hyperglycemia, dyslipidemia and abdominal obesity. This pathology has been widely discussed due to the impact of cardiovascular disease (CVD), has been a concern for public health. In addition to the classic risk factors of this syndrome, has been indicated the presence of a low-grade chronic inflammation in their patients, which is considered a key point in the development of atherosclerosis and CVD. Some inflammator

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Cunha, Maria Gabriela da. "Avaliação do efeito de extratos de compostos fenólicos da jabuticaba Sabará (Myrciaria jaboticaba (Vell.) Berg) administrados a camundongos C57BL/6 alimentados com dieta hiperlipídica com alto teor de sacarose." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/9/9131/tde-26092016-124429/.

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Crescem a cada dia os índices globais de obesidade associada à síndrome metabólica (SM) e à inflamação. Sob este aspecto, os compostos fenólicos (CFs) exercem papel importante, especialmente no que diz respeito às suas propriedades anti-inflamatória e antiobesogênica. A jabuticaba Sabará (Myrciaria jaboticaba (Vell.) Berg) é uma fruta nativa bem aceita pelos brasileiros e rica em CFs. O objetivo deste trabalho foi avaliar o efeito da administração diária de extratos ricos em CFs desta fruta a camundongos C57BL/6, alimentados com dieta hiperlipídica com alto teor de sacarose (HFHS) por 8 semana

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Olsson, Frida. "Glucose and its association with metabolic factors and biomarkers in patients experiencing symptomatic knee osteoarthritis : A cross-sectional study." Thesis, Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-36856.

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Background Osteoarthritis (OA) is a long-term chronic disease that affects the joints and creates stiffness, pain and impaired movement. Knee osteoarthritis is the most common form of OA and affects all tissues of the joint, including bone, muscles, synovia, and cartilage. Previously, OA was accepted as only an age- or mechanical stress-related degenerative joint disease, but more recent studies suggest that OA is a heterogenous disease including inflammatory, hormonal and metabolic factors such as abdominal obesity (visceral fat), lipids (cholesterol, HDL, LDL and triglycerides) and glucose.

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Bjermo, Helena. "Dietary Fatty Acids and Inflammation : Observational and Interventional Studies." Doctoral thesis, Uppsala universitet, Klinisk nutrition och metabolism, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-156074.

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Dietary fat quality influences the risk of type 2 diabetes and cardiovascular disease. A low-grade inflammation is suggested to contribute to the disease development, often accompanied by obesity. Whereas n-3 polyunsaturated fatty acids (PUFA) have been considered anti-inflammatory, n-6 PUFA have been proposed to act pro-inflammatory. Saturated fatty acids (SFA) act pro-inflammatory in vitro. This thesis aimed to investigate effects of different fatty acids on low-grade inflammation in observational and interventional studies. In Paper I and II, fatty acid composition in serum cholesterol este

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Axelsson, Jonas. "Fat tissue, adipokines and clinical complications of chronic kidney disease /." Stockholm : Department of Clinical Science, Intervention and Technology, Divisions of Renal Medicine and Baxter Novum, Karolinska institutet, 2006. http://diss.kib.ki.se/2006/91-7140-653-0/.

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Fourie, Catharina Maria Theresia. "The influence of HIV infection on vascular function in an African population / Catharina Maria Theresia Fourie." Thesis, North-West University, 2010. http://hdl.handle.net/10394/4356.

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Saukkonen, T. (Tuula). "Prediabetes and associated cardiovascular risk factors:a prospective cohort study among middle-aged and elderly Finns." Doctoral thesis, Oulun yliopisto, 2012. http://urn.fi/urn:isbn:9789514299858.

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Abstract It has been proposed that in addition to oral glucose tolerance test, detected by impaired fasting glucose (IFG), impaired glucose tolerance (IGT), glycosylated hemoglobin (HbA1c 5.7–6.4%) can be used for screening individuals at high risk of developing type 2 diabetes and CVD. The aim of the present study was to assess whether the use of ADA 2010 prediabetes definition, especially the use of HbA1c 5.7–6.4% may detect different individuals with prediabetes as compared to the use of IFG or IGT, and whether the traditional CVD-risk factors differed between these definitions. Furthermore

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Miyahara, Carine Teles Sangaleti. "Efeitos da galantamina sobre biomarcadores inflamatórios e adipocinas em pacientes com síndrome metabólica." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-19062017-151724/.

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INTRODUÇÃO: O componente inflamatório se constitui em potente foco de estudo e intervenção no manejo das anormalidades da Síndrome Metabólica. Estudos recentes demonstram que a Galantamina, um anticolinesterásico que potencializa a via antiinflamatória colinérgica, reduz a adiposidade visceral e suprime a liberação excessiva de adipocinas e citocinas pró-inflamatórias em modelos experimentais com animais obesos. Este estudo propôs a investigação dos efeitos do tratamento com Galantamina nos componentes da modulação autonômica cardiovascular, nos níveis de marcadores inflamatórios, em parâmetro

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Bernardes, Nathalia. "Mecanismos associados ao desenvolvimento das complicações cardiometabólicas em SHR submetidos à sobrecarga de frutose: papel do treinamento físico aeróbio." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-04082016-154155/.

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Neste estudo testamos a hipótese que alterações no controle autonômico precedem alterações cardiometabólicas em animais espontaneamente hipertensos tratados com frutose (SHR). Adicionalmente avaliamos os efeitos do treinamento físico aeróbio (TFA) no curso temporal das disfunções observadas neste modelo de síndrome metabólica. Para isso, foram utilizados ratos machos Wistar e SHR divididos em grupos (n=8): Controle (C), Hipertenso (H), Hipertenso+Frutose (HF) e Hipertenso+Frutose+Treinamento Físico (HFT). A sobrecarga de frutose (100g/L) e o TFA (esteira: 1h/d., 5d/sem.) foram iniciados 30 dia

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Hinnouho, Guy-Marino. "Phénotype « obésité à profil cardiométabolique normal » et risque de pathologies chroniques dans les cohortes Whitehall II et GAZEL." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T060/document.

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L’obésité est devenue un véritable problème de santé publique. Elle est fréquemment associée à plusieurs anomalies cardiométaboliques telles que l’hypertension artérielle, l’insulinorésistance et les dyslipidémies qui font le lit du diabète de type 2 et des maladies cardiovasculaires. Cependant la fréquence de ces anomalies varie considérablement parmi les sujets obèses faisant de cette maladie chronique une situation clinique très hétérogène. A ce titre un nouveau concept a émergé, impliquant une population de patients sans facteurs de risque apparents, appelé « obèse métaboliquement sain » o

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Benetti, Chane Basso. "IMPLICAÇÕES DOS FATORES DE RISCO PARA DOENÇAS CARDIOVASCULARES." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/6726.

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Cardiovascular diseases (CVD) are a major public health problem worldwide, representing the leading cause of morbidity and mortality. The risk of developing CVD is evaluated based on the analysis of characteristics that increase the chances of future cardiovascular events. Knowledge of these risk factors for cardiovascular disease becomes crucial in the development of prevention strategies. Although many studies have been conducted on CVD, each population has its own characteristics and hardly, the behavioral and metabolic factors will affect subjects in the same manner. Thus, this study analy

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Camargo, Rodolfo Gonzalez. "Resistência à insulina na caquexia associada ao câncer e na síndrome metabólica: papel dos macrófagos ativados pela insulina e do miRNA-21-5p." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-10112016-112543/.

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A Caquexia associada ao câncer (CC) e a Síndrome Metabólica (MetS) apresentam características comuns como inflamação e resistência à insulina. Na MetS, a resistência à insulina é compensada pela hiperinsulinemia, que pode contribuir para a resistência à insulina através do aumento da inflamação, em particular, no fígado, onde a concentração de insulina é mais elevada. Esta hipótese foi testada neste estudo. Células da linhagem humanas U937 foram diferenciadas em macrófagos e expostas à insulina, LPS e PGE2. A insulina induziu a expressão gênica de IL-1β e IL-8 e potencializou a indução pr

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