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Dissertations / Theses on the topic 'Inflammation of the genital organs'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Звягіна, Н. Ю. "Вивчення терапевтичних підходів реабілітації піхвового вмісту у жінок, що перенесли запальні захворювання статевих органів з використанням пробіотиків". Thesis, Сумський державний університет, 2014. http://essuir.sumdu.edu.ua/handle/123456789/36426.

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Сучасні підходи до лікування захворювань органів малого тазу (ЗЗОМТ) базуються на використанні антибіотиків різноманітних груп, які разом із боротьбою з запаленням викликають значні порушення в біоценозі статевих шляхів у жінок, що потребує подальшого поновлення нормальних співвідношень мікроорганізмів слизової піхви. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/36426

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2

Reynolds, Paul N. "The role of tachykinins in airway inflammation and bronchial hyper-responsiveness /." Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phr464.pdf.

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3

Zheng, Ling 1958. "Airway inflammation and remodelling post human lung transplantation." Monash University, Dept. of Medicine, 2002. http://arrow.monash.edu.au/hdl/1959.1/8099.

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4

Laing, Ingrid A. "Candidate gene approach to investigating airway inflammation and asthma /." Connect to this title, 2004. http://theses.library.uwa.edu.au/adt-WU2005.0097.

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5

Ratnawati, Ratnawati Prince of Wale Hospital Clinical School UNSW. "Exhaled nitric oxide in asthmatic airway inflammation." Awarded by:University of New South Wales. Prince of Wale Hospital Clinical School, 2006. http://handle.unsw.edu.au/1959.4/25729.

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Measuring the level of exhaled NO (eNO) in the breath is a new method to monitor airway inflammation in asthma and may have a role in the management of asthma. The hypotheses were that eNO will reflect the degree of inflammation in chronic asthma, and will indicate how anti- inflammatory therapy should be altered to improve asthma control. Three studies were performed to test the hypotheses. A cross sectional study was performed to define the normal range of eNO and to compare this range with those who have asthma or atopy. The second study was observational, to compare the level of eNO during

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6

Makepeace, Benjamin Lawrence. "The aetiology and cell biology of inflammation in sexually transmitted bacterial infections." Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327260.

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7

Sargeant, Penelope. "Vulvar vestibulitis syndrome : an ultrastructural and epidemiological investigation." Thesis, University of Plymouth, 1996. http://hdl.handle.net/10026.1/2642.

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Vulvar Vestibulitis Syndrome (VVS) is a chronic inflammatory condition affecting the vestibular epithelium of the vulva, which has been estimated to affect 15% of the female population (Goetsch, 1991). Many studies have attempted unsuccessfully, to elucidate the cause of this condition, and few advancesh ave beenm adet owards the understandingo f the associatedin flammatory responseT. he initial, and principal aim of this investigation was to characterise normal vestibular epithelium using electron microscopy. The ultrastructural characteristics of normal vestibular epithelium were compared wi

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8

Anahtar, Melis Nuray. "The Contribution of Cervicovaginal Microbiota and Hormonal Contraceptives to Genital Inflammation and HIV Acquisition Risk." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467194.

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The HIV epidemic persists in many parts of the world, with the majority of new infections occurring through the female genital tract (FGT). The permissiveness of the genital mucosa to HIV is modulated by the integrity of the epithelial barrier, the presence of pro-inflammatory cytokines, and the frequency of CCR5+CD4+ T cell targets. Here we focus on two biological perturbations: endogenous alterations in cervicovaginal bacteria and exogenous injectable progestin-only contraceptives (IPCs). We examine their effects on the genital mucosal environment and their link to HIV susceptibility in a co

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9

Carey, Alison Jane. "Development of novel vaccine strategies to prevent genital tract chlamydial infections." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/48734/1/Alison_Carey_Thesis.pdf.

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Chlamydia trachomatis is the most prevalent bacterial sexually transmitted infection in the developed world and the leading cause of preventable blindness worldwide. As reported by the World Health Organization in 2001, there are approximately 92 million new infections detected annually, costing health systems billions of dollars to treat not only the acute infection, but also to treat infection-associated sequelae. The majority of genital infections are asymptomatic, with 50-70% going undetected. Genital tract infections can be easily treated with antibiotics when detected. Lack of treatment

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10

Laing, Ingrid A. "Candidate gene approach to investigating airway inflammation and asthma." University of Western Australia. School of Paediatrics and Child Health, 2005. http://theses.library.uwa.edu.au/adt-WU2005.0097.

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[Truncated abstract] Asthma genetic studies have identified many genes that contribute to the pathogenesis of asthma and related variables. Members of the secretoglobin family appear to play an important role in controlling airway inflammation but they have received relatively little attention in asthma genetic research. In this thesis, I have investigated the genes of two members of the secretoglobin family (16 kDa Clara cell secretory protein (CC16) and secretoglobin 3A2 (SCGB3A2)) that are expressed at high levels in the airways and are important anti-inflammatory agents. The overall aim of

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11

Tezze, Caterina. "OPA1 orchestrates precocious senescence, degeneration of multiple organs and premature death thought inflammation and metabolic changes." Doctoral thesis, Università degli studi di Padova, 2019. http://hdl.handle.net/11577/3425910.

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A healthy mitochondrial network is essential for post-mitotic tissues like muscles. During aging sarcopenia, mitochondria-shaping machinery declines. On the contrary, lifelong exercise preserves it. OPA1 is a profusion protein that plays an essential role in mitochondrial dynamics. Interesting, OPA1 protein decreases in sedentary seniors and in 18 months-old mice. Exercise in aged mice is sufficient to increase OPA1 levels in old muscles. To address the OPA1 role in skeletal muscle and further investigate its involvement in aging, we generated muscle-specific ko mice. Indeed, Opa1 mice show se

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12

Bergmann, Paavo Karl [Verfasser], and Michael [Akademischer Betreuer] Heethoff. "Development and function of the genital organs in the parthenogenetic oribatid mite Archegozetes longisetosus Aoki 1965 / Paavo Karl Bergmann ; Betreuer: Michael Heethoff." Tübingen : Universitätsbibliothek Tübingen, 2015. http://d-nb.info/1163397261/34.

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13

Сміян, Світлана Анатоліївна, Светлана Анатольевна Смиян, Svitlana Anatoliivna Smiian та А. В. Русанова. "Особливості перебігу запальних захворювань жіночих статевих органів і значення лейкоцитарного індексу інтоксикації в їх діагностиці". Thesis, Вид-во СумДУ, 2007. http://essuir.sumdu.edu.ua/handle/123456789/4878.

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14

Rudoy, Andrey. "Evolution of the male genitalia in the genus Limnebius Leach 1815, family Hydraenidae (Coleoptera)." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/398993.

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In the present work I analysed different aspects of the evolution of genus Limnebius (Coleoptera, Hydraenidae), including its molecular evolution using mitochondrial (COI, 16S, tRNA-leu, NAD1) and nuclear markers (18S, 28S) as well as morphological data, for which I measured more than 3000 exemplars from 123 species. The study concentrated on the shape of the male genitalia, as the species of Limnebius are extremely uniform in their external characters. In the molecular phylogeny, which included 65 species and was obtained with BEAST, there were two principal branches, coinciding with the anci

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15

Laureckienė, Žaneta. "Paršavedžių genitalinio trakto uždegimų etiologija, prevencija ir gydymas." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2006. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2006~D_20061206_120304-93802.

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1.The prevalence of sow reproductive organ disease was ascertained in the Lithuania’s Republic’s large hog complexes; 2.The dominating microflora in sow reproductive organs and its influence in post-weaning fertilisation were established; 3.The influence of prophylactic use of recommended feed supplements Spectinomix 110 and Lincosint 100 on reproductive organ microflora and piglet to weaning health was evaluated; 4.The prophylactic and treatment efficacy of veterinary preparations 2.5% sol. Cobactan®, Metricure®, Clamoxyl ® Metritis was established in sows with post-partum uterine inflammatio

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16

Davis, Laura D. R. "The Biodistribution of 14C in the Digestive Organs of Rats Fed [14C]CD14 Protein." Thesis, Université d'Ottawa / University of Ottawa, 2010. http://hdl.handle.net/10393/12911.

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Human milk contains ~ 25 µg/mL of soluble cluster of differentiation 14 (sCD14) protein, a pattern recognition receptor (PRR) that triggers the innate immune system to respond to bacterial lipopolysaccharide (LPS). To date, the role of CD14 in the digestive tract of breast fed infants has not been well characterized and is the subject of this thesis. To investigate the biodistribution of proteins such as CD14 in vivo, a novel method for 14C radiolabeling of proteins to high specific radioactivity was developed using in vacuo methylation. Bovine serum albumin (BSA) and casein were used as test

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17

Goshovska, A. V. "Features of the vascular component at the stage of the placental complex formation against a background of inflammatory diseases of the female genital organs." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18715.

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18

Konstantinus, Iyaloo. "Effect of progestin-based hormonal contraceptives on genital inflammation and Th17 cell activation in adolescents at high risk for HIV infection." Doctoral thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/30408.

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Background: Adolescent girls and young women (AGYW) are at high risk for HIV infection, particularly in Southern Africa. In addition, some hormonal contraceptives (HC), such as progestin only-injectable contraceptives DMPA and NET-EN, have been associated with significantly increased risk for HIV infection. These HC together with sexual immaturity may increase activation of CD4+ T cells in the female reproductive tract (FRT), which are target cells for HIV infection. NuvaRing, also a long-acting progestin-containing contraceptive albeit topical, has recently been introduced to South Africa, an

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19

Santos, Paulo Ramos da Silva. "Estudo ultraestrutural do desenvolvimento da espermatogênese e da via espermática de preás (Galea spixii, Wagler, 1831) criados em cativeiro." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-01112013-154704/.

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A potencialidade da produção de inúmeras espécies silvestres vem sendo pesquisada em todo mundo, demonstrando que estas podem se transformar em fontes renováveis de produtos de grande rentabilidade. Alguns espécimes vêm sendo explorados indiscriminadamente como fonte de proteína de origem animal, como o preá (Galea spixii) que já está sendo criado com objetivo de manejo e reprodução, com repercussão econômica. Para perspectiva de produção comercial e de preservação da espécie, tem de haver estudo das diversas etapas do desenvolvimento testicular, especialmente daquelas associadas à puberdade e

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20

Machado, Alex Sander Dias. "Órgãos genitais femininos do Lobo-marinho-sul-americano (Arctocephalus australis): uma abordagem morfofuncional." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-10022011-085003/.

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O Lobo-marinho-sul-americano (A. australis) apresenta particularidades em seu ciclo reprodutivo que revelam sua interação com o ecossistema onde habita. Dentre estas podemos citar o intervalo entre partos de 12 meses, a sincronização dos partos e cópulas no início do verão, umlongo período de diapausa e uma implantação do blastocisto no inicio do inverno, que ocorre 4 a 5 meses após a cópula. A anatomia e fisiologia reprodutivas desta espécie ainda não foram profundamente estudadas. O presente trabalho tem como objetivo, a partir do emprego de métodos não invasivos de pesquisa, descrever a ana

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21

Lusoli, Rita de Cássia. "Prevenção e diagnóstico de lesões HPV induzidas e carcinoma anal em mulheres atendidas na rede básica de saúde da cidade de Botucatu pelo método escovado do canal anal /." Botucatu, 2013. http://hdl.handle.net/11449/97711.

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Orientador: Rogério Saad Hossne<br>Coorientador: Sidney Roberto Nadal<br>Banca: Fábio Vieira Teixeira<br>Banca: Maria Aparecida C. Arruda Henry<br>Resumo: O Papiloma Vírus Humano (HPV), é considerado um problema mundial de saúde pública, sendo a doença sexualmente transmissível mais prevalente. Guarda uma relação direta com o risco e a incidência do câncer do canal anal. Seu diagnóstico, tratamento e seguimento são de extrema importância. Neste sentido o escovado do canal anal tem um papel fundamental no rastreamento e seguimento das lesões HPV induzidas e consequente evolução para o câncer an

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22

Masson, Lindi. "The impact of sexually transmitted infections and inflammation in the female genital tract and blood on susceptibility to HIV-1 infection and disease progression." Doctoral thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/18609.

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Background. In sub-Saharan Africa, which has the highest prevalence of HIV-1 worldwide, most newHIV-1 infections occur by sexual transmission to women. Recent studies in non-human primates have demonstrated that pro-inflammatory cytokine production in the genital tract is necessary for immune cell recruitment and establishment of simian immunodeficiency virus (SIV) infection following vaginal inoculation. The aims of this study were to evaluate the relationships between inflammation in the female genital tract and (i) susceptibility to HIV-1 infection and (ii) subsequent disease progression in

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23

Dougherty, Liam R. "Pre- and post-copulatory sexual selection in two species of lygaeid seed bug." Thesis, University of St Andrews, 2015. http://hdl.handle.net/10023/7246.

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Sexual selection arises via competition for access to mates, and is thus intimately tied to the social environment. For example, individual mating success may depend strongly on how many rivals or mating partners are available. Studies of mate choice and sexual selection may vary the number of mates a subject is presented with during mating experiments, yet it is not clear how this influences the strength and shape of sexual selection acting on traits in either sex. In this thesis I investigate the effect of social environment on sexual selection acting in two closely-related species of lygaei

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24

Dansou, Boris. "Effets opposés des calpaïnes intra- et extra-cellulaires sur les lymphocytes T dans le développement de l'inflammation." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2010. http://tel.archives-ouvertes.fr/tel-00814865.

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La recherche de nouvelles cibles est indispensable pour le traitement des maladies inflammatoires en constante progression depuis quelques décennies dans les pays industrialisés. Les calpaïnes pourraient être de telles cibles. Ce sont des protéases à cystéine dont l'activité est augmentée par le calcium et limitée par la calpastatine qui est un inhibiteur endogène spécifique. Elles sont présentes dans les cellules T dont l'activation conduit au développement des pathologies immunes et inflammatoires. Dans cette étude, nous avons montré que les calpaïnes intracellulaires modulent l'activité des

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25

Greatti, Mariana Morena de Vieira Santos [UNESP]. "Flora intermediária em mulheres em idade reprodutiva: aspectos inflamatórios, atividade de sialidases e carga bacteriana." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/123317.

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Made available in DSpace on 2015-05-14T16:53:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-08-28Bitstream added on 2015-05-14T16:58:58Z : No. of bitstreams: 1 000829155.pdf: 363339 bytes, checksum: dbf6106e4f09a1f8ded3d4f562685ee4 (MD5)<br>Espécies de lactobacilos são os principais componentes da microbiota vaginal e a manutenção do predomínio lactobacilar é importante para proteção desse ambiente contra possíveis patógenos. A vaginose bacteriana é uma condição em que se observa a perda de lactobacilos e substituição desses microrganismos por espécies bacterianas, anaeróbias em s

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26

Greatti, Mariana Morena de Vieira Santos. "Flora intermediária em mulheres em idade reprodutiva : aspectos inflamatórios, atividade de sialidases e carga bacteriana /." Botucatu, 2014. http://hdl.handle.net/11449/123317.

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Orientador: Camila Marconi<br>Coorientador: Màrcia Guimarães da Silva<br>Banca: Andrea da Rocha Tristão<br>Banca: Ana Katherine da Silveira Gonçalves<br>Banca: Eliane Melo Brolazo<br>Banca: Cristina Maria Garcia de Lima Parada<br>Resumo: Espécies de lactobacilos são os principais componentes da microbiota vaginal e a manutenção do predomínio lactobacilar é importante para proteção desse ambiente contra possíveis patógenos. A vaginose bacteriana é uma condição em que se observa a perda de lactobacilos e substituição desses microrganismos por espécies bacterianas, anaeróbias em sua maioria. Tal

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27

Munrós, Feliu Jordina. "Nous mecanismes en la fisiopatologia de l’endometriosi profunda." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/667447.

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L’endometriosi és una patologia ginecològica benigna, la fisiopatologia de la qual és en part desconeguda, que afecta fins a un 10% de les dones en edat reproductiva. Aquesta malaltia representa una gran càrrega econòmica i social, ja que les pacients pateixen, al llarg de la seva vida fèrtil, múltiples cirurgies i hospitalitzacions, baixes laborals i problemes reproductius. S’ha descrit la implicació de factors proinflamatoris, neoangiogènics i procoagulants a la seva persistència i progressió, pel que avui en dia l’endometriosi és considerada una malaltia inflamatòria crònica. L’endometriosi

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28

Lusoli, Rita de Cássia [UNESP]. "Prevenção e diagnóstico de lesões HPV induzidas e carcinoma anal em mulheres atendidas na rede básica de saúde da cidade de Botucatu pelo método escovado do canal anal." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/97711.

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Made available in DSpace on 2014-06-11T19:29:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-04-16Bitstream added on 2014-06-13T20:08:50Z : No. of bitstreams: 1 000749088.pdf: 2884185 bytes, checksum: 7b3dbfabfdaeaf228b68393fedd5e4fd (MD5)<br>O Papiloma Vírus Humano (HPV), é considerado um problema mundial de saúde pública, sendo a doença sexualmente transmissível mais prevalente. Guarda uma relação direta com o risco e a incidência do câncer do canal anal. Seu diagnóstico, tratamento e seguimento são de extrema importância. Neste sentido o escovado do canal anal tem um papel funda

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29

Borges, Edson Moreira. "Morfologia dos órgãos genitais masculinos de pacas (Agouti paca Linnaeus, 1766)." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-07082007-111144/.

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Estudou-se a posição e morfologia dos órgãos genitais masculinos de dez pacas-machos adultas; cinco espécimes fixados em solução aquosa de formol a 10% foram estudados macroscopicamente; de cinco espécimes foram coletados fragmentos dessas estruturas, que após procedimento usual para a inclusão em paraplast e historesina, foram analisados microscopicamente. Externamente identificou-se o escroto na época da migração dos testículos que apresentavam parênquima estruturado em túbulos seminíferos em cuja membrana basal repousava o epitélio germinativo; estes órgãos também podiam estar na cavidade a

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30

Takamine, Cristiane Naoko. "Aspectos macro e microscópicos dos órgãos genitais masculinos no jacaré-do-Pantanal (Caiman crocodylus yacare) - DAUDIN 1802." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-02042007-184005/.

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Foram utilizados dez jacarés - do - Pantanal (Caiman crocodylus yacare), machos de faixa etária juvenil; sete espécimes foram destinados ao estudo macroscópico e os outros três foram utilizados para o estudo microscópico de luz. Após a abertura da cavidade pleuroperitoneal foi observado e identificado que os testículos são em pares e apresentam-se aderidos a parede dorsal da cavidade pleuroperitoneal. O epidídimo é alongado e muito enovelado, encontra-se na extremidade cranial do testículo, seguindo medialmente até sua extremidade caudal, onde inicia-se com o ducto deferente e posterior aber

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Gumbi, Pamela. "HIV pathogenesis in the female genital tract during chronic HIV infection : the impact of inflammation, T cell memory differentiation status and homeostatic cytokines on mucosal T cell immunity." Doctoral thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/10501.

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Includes bibliographical references (leaves 124-150).<br>The female genital tract serves as the major portal of entry for human immunodeficiency virus (HIV). Local immune factors unique to the mucosal micro-environment such as the genital tract cytokine milieu or the activation/differentiation status of T cells may play a significant role in heterosexual transmission of HIV and subsequent pathogenesis. Elucidation of the mechanisms underlying the persistent recruitment, activation and differentiation of mucosal T cells will give crucial insight into potential therapeutic targets to restore eff

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32

Navarro, Y. Garcia Fabrice. "Inflammation et infiltration monocytaire associées à la dégénérescence neuronale induite par un status epilepticus chez le rat." Phd thesis, Université Claude Bernard - Lyon I, 2007. http://tel.archives-ouvertes.fr/tel-00195393.

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La pharmaco-résistance des épilepsies du lobe temporal serait étroitement liée à une perte de neurones dans l'hippocampe qui pourrait résulter d'une inflammation. Chez le rat soumis à une épileptogenèse expérimentale, nous avons caractérisé la réponse inflammatoire de l'hippocampe. Celle-ci précède la mise en place de la neurodégénérescence et consiste en une forte production de cytokines pro-inflammatoires par la microglie activée ainsi qu'en une infiltration de monocytes/ macrophages. La progression des monocytes dans le parenchyme cérébral serait facilitée par la dégradation des chaînes de

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Fernandez, Daniela Seko. "Morfologia do trato reprodutor masculino de capivara: estudo das glândulas anexas à uretra." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-06082007-100037/.

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Para a realização dos estudos macro e microscópico das glândulas anexas à uretra, foram utilizadas doze capivaras (Hydrochaeris hydrochaeris) machos e adultos. Dez animais para estudo macroscópico e dois para o estudo histológico, dos quais foram coletados fragmentos das glândulas acessórias, imersos em solução fixadora de Bouin, lavados, cuidadosamente, em alcool de 70° ao absoluto. A seguir, foram submetidos aos processos histológicos de rotina e corados pelos métodos de Hematoxilina/Eosina e Tricrômico de Masson. Os resultados morfológicos encontrados foram: o ducto deferente possui um espe

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34

Tang, Chongfa. "The inflammatory response of primary epithelial cells of the female genital tract to Chlamydia trachomatis infection, and its exacerbation by type-I interferon." Electronic Thesis or Diss., Sorbonne université, 2022. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2022SORUS121.pdf.

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Chlamydia trachomatis est une bactérie intracellulaire obligatoire, qui se développe principalement dans cellules épithéliales des muqueuses du tractus génital. Asymptomatiques dans la plupart des cas, les infections par ce pathogène peuvent entrainer des inflammations pelviennes. L’inflammation peut elle-même engendrer des fibroses et mener à une infertilité tubaire chez les femmes. Il est important d’étudier la réponse des cellules épithéliales, qui constituent la première ligne de défense contre l’infection par C. trachomatis, pour mieux comprendre ses manifestations pathologiques dans le t

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35

Dalmas, Elise. "Inflammation du tissu adipeux chez le sujet obèse et au cours de la perte de poids : nouveau dialogue paracrine entre macrophages et lymphocytes." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2012. http://tel.archives-ouvertes.fr/tel-00828183.

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L'obésité est un état inflammatoire chronique dit de " bas grade ", associé à l'augmentation de facteurs pro-inflammatoires dans la circulation et le tissu adipeux. Chez les sujets obèses, nous montrons qu'une série de facteurs inflammatoires sériques évoluent selon une régulation bi-phasique au cours de la perte de poids induite par chirurgie bariatrique, avec une diminution drastique à 3 mois suivie d'un rebond et d'une stabilisation à 1 an. Le statut nutritionnel des patients est un déterminant majeur de ce profile inattendu. Chez ces sujets, nous mettons en évidence un enrichissement en mo

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Béliard-Lasserre, Sophie. "Etude du rôle des sous-populations monocytaires dans l'obésité et l'insulinorésistance." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2011. http://tel.archives-ouvertes.fr/tel-00824652.

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L'obésité est associée à une inflammation de bas grade et à une augmentation du nombre de monocytes circulants. Ces cellules sont des acteurs majeurs de l'immunité innée. Chez la souris, ils se subdivisent en deux sous-populations : les monocytes Gr1high et les Gr1low. Des études récentes suggèrent que ces 2 sous-populations exercent des fonctions distinctes mais leur rôle respectif dans la physiopathologie de l'obésité est à ce jour inconnu. Nos travaux chez la souris démontrent qu'un régime riche en graisse induit une monocytose principalement due à l'expansion de monocytes Gr1low et une for

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Pirault, John. "Implication des phagocytes mononucléés dans les pathologies inflammatoires chroniques : exploration d'un modèle murin d'athérosclérose et du xanthogranulome chez l'homme." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2012. http://tel.archives-ouvertes.fr/tel-00833457.

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Les pathologies inflammatoires chroniques représentent la première cause de mortalité dans le monde avec une part importante des cardiopathies et autres maladies lipido-inflammatoires telles que l'athérosclérose. Ainsi, comprendre l'ensemble des mécanismes impliqués dans l'initiation mais aussi la résolution de ces maladies représente un enjeu majeur en santé publique. Nos travaux sur l'implication des phagocytes mononucléés dans des modèles murins d'athérosclérose montrent qu'en modulant la demi-vie de certaines cellules du système immunitaire on est capable de limiter le développement de la

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Youssef, Hala. "L'obésité de l'adolescent Libanais : étude épidémiologique et effets d'un exercice aigu et chronique sur le stress oxydant d'adolescentes en surpoids." Phd thesis, Université Rennes 2, 2008. http://tel.archives-ouvertes.fr/tel-00562543.

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Notre première étude épidémiologique s'est intéressée aux causes et facteurs de l'obésité juvénile au Liban. Elle montre que 17.1 % des adolescents Libanais sont en surpoids et 4.5% sont obèses. Les garçons sont plus en surpoids et obèses comparés aux filles (23% et 8.1% vs 12.7 et 1.8%). L'obésité, surtout chez les garçons, est associée à des habitudes sédentaires, à une déstructuration alimentaire et à un statut socioéconomique élevé. L'excès de masse grasse et les désordres métaboliques et hormonaux associés à l'obésité, surtout chez les adolescentes, aggravent le stress oxydant (SO). Ainsi

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Teixeira, Dulcinea Gonçalves. "Estudo anatômico descritivo dos órgãos genitais masculinos do macaco-prego (Cebus apella Linnaeus, 1758)." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-20042007-152900/.

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A Anatomia comparada de mamíferos é tema de grande interesse em pesquisas e tem como objetivo buscar conhecimentos que possam auxiliar o entendimento do binômio unidadevariedade. O conhecimento da Anatomia de qualquer animal silvestre é de importância capital para a sua preservação e proteção (RIBEIRO, 2002). Os primatas do novo mundo estão distribuídos na Região Neotropical das Américas Central e do Sul, (RYLANDS; MITTERMEIER; RODRÍGUEZ-LUNA, 1997). O Cebus apella, animal das matas do continente sul-americano, geogra. camente distribuído por quase todo o Brasil, adapta-se bem à vida em cative

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Béguin, Pauline. "Caractère biphasique de l'hypoxie intermittente : mécanismes cardioprotecteurs induits par une exposition aiguë et conséquences inflammatoires d'une exposition chronique." Phd thesis, Université Claude Bernard - Lyon I, 2006. http://tel.archives-ouvertes.fr/tel-00149355.

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L'hypoxie intermittente (HI) est une composante majeure du syndrome d'apnées obstructives du sommeil (SAOS). Cette pathologie affectant 5% de la population générale, correspond à des épisodes répétitifs de collapsus du pharynx pendant le sommeil, à l'origine d'une hypoxie. Le SAOS est associé à une augmentation du risque cardiovasculaire. <br />Le but de ce travail est de caractériser d'une part, les effets sur la fonction cardiaque d'une exposition aiguë chez le rat, et d'autre part, les conséquences inflammatoires, marqueurs précoces de l'athérogenèse, d'une exposition chronique chez la sour

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Yang, Liqun. "Characterization of the Physiologic Function of NF-κB2 p100". University of Toledo Health Science Campus / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=mco1263334529.

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Pereira, Simone Machado. "Morfologia dos órgãos genitais masculinos do tucuxi amazônico (Sotalia fluviatilis)." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-08072008-103909/.

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Sotalia fluviatilis é o único Delphinidae que ocorre em água doce, sendo endêmico da região amazônica. É considerada pela IUCN como espécie insuficientemente conhecida (dados deficientes), estando incluída no Apêndice I da CITES como espécie ameaçada de extinção. Atualmente, vem sendo alvo de caça ilegal para utilização como isca na pesca de um bagre, conhecido como piracatinga. Sendo assim, toda medida para melhor compreensão da biologia desta espécie é de suma importância para assegurar medidas eficazes de conservação no futuro. Neste trabalho foi realizada a descrição morfológica dos órgãos

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Pinaud, Frédéric. "MECANOTRANSDUCTION DE LA PRESSION ET DU DÉBIT DANS LA MICROCIRCULATION : RÔLE DE LA PULSATILITÉ." Phd thesis, Université d'Angers, 2012. http://tel.archives-ouvertes.fr/tel-00999425.

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L'utilisation de la circulation extracorporelle (CEC) en chirurgie cardiaque est indispensable. Cependant le bénéfice de maintenir ou pas la pulsatilité durant la CEC reste controversé. Par ailleurs, la mécanotransduction du flux et de la pression dans la microcirculation fait l'objet de peu d'études. La pulsatilité, caractéristique essentielle de la perfusion physiologique est donc importante à prendre en considération dans ces études. L'objectif de ce travail a été d'étudier les effets de la pulsatilité sur la pharmacologie et la mécanotransduction ( dilation au flux, tonus myogénique ) des

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Lacraz, Grégory. "Relation entre Stress Oxydant et Homéostasie Glucidique au cours du Diabète de Type 2 : Adaptation de la Cellule β Pancréatique". Phd thesis, Université Paris-Diderot - Paris VII, 2009. http://tel.archives-ouvertes.fr/tel-00433556.

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Le but de ce travail a été d'étudier l'adaptation β-cellulaire au stress oxydant (SO) dans un modèle animal de diabète de type 2, le rat GK/Par. Dans le premier volet de cette thèse, nous avons évalué le stress oxydant insulaire et l'impact des espèces réactives de l'oxygène (ERO) sur la sécrétion de l'insuline. Les îlots de rats diabétiques GK/Par apparaissent protégés contre le SO, car (i) les marqueurs de SO ciblent essentiellement la périphérie insulaire (aires vasculaires et inflammatoires) ; (ii) l'accumulation d"ERO est plus faible comparativement aux îlots témoins (Wistar) ; (iii) leur

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Mahmood, Dler Faieeq Darweesh. "Thioredoxin-1 (Trx1) : a new target in the treatment of cardiovascular diseases." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2014. http://tel.archives-ouvertes.fr/tel-01069096.

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The cardiovascular diseases (CVDs), resulting from complications of atherosclerosis, remain the leading cause of morbidity and death worldwide. Atherosclerosis as a chronic inflammatory disease, involves both innate and adaptive arms of immunity in which macrophages play the orchestral role in modulating lesion initiation, progression, and potentially devastating thrombotic complications. Available evidences support the notion of a central role of oxidative stress, due mainly to the imbalance between antioxidants and reactive oxygen species (ROS) in CVDs. Furthermore, the pathology is frequent

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Акімова, В. М. "Імунні механізми в патогенезі запалення органів черевної порожнини". Thesis, Львівський національний медичний університет ім. Данила Галицького, 2019. http://essuir.sumdu.edu.ua/handle/123456789/74588.

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У дисертаційній роботі вирішене важливе завдання – покращення диференційної діагностики запальних процесів органів черевної порожнини, шляхом виявлення імунних механізмів патогенезу гострого і хронічного запалення. Було обстежено 226 хворих на гострий неспецифічний запальний процес органів черевної порожнини (гострий апендицит, гострий калькульозний холецистит, гострий мезаденіт) і 60 осіб хворих на абдомінальний туберкульоз, який представляє специфічне хронічне запалення. Встановлено, що гостре запалення супроводжується нейтрофільним типом гемограми, активацією гуморальної та кілерної ланок і

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Merritt, Thomas J. S. "Regulation of the development of sex-specific genital muscles by the doublesex gene." Thesis, 1994. http://hdl.handle.net/1957/35205.

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Reynolds, Paul N. (Paul Nigel). "The role of tachykinins in airway inflammation and bronchial hyper-responsiveness." 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phr464.pdf.

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Bibliography: leaves 217-244. Tachykinins are implicated in the mediation of airway inflammatory responses and may have roles in airway remodeling and healing. The actions of tachykinins are mediated by specific receptors, designated NK1, NK2 and NK3. Tachykinin degredation, an important mechanism for limiting the effects of these peptides, is principally mediated by neutral endopeptidase (NEP). This thesis investigates the role of tachykinins, in vivo, in an ovine model and in human airway epithelium. Results show that the nett effect of tachykinins in the airway will depend on the relative b

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Reynolds, Paul Nigel. "The role of tachykinins in airway inflammation and bronchial hyper-responsiveness / Paul N. Reynolds." Thesis, 1999. http://hdl.handle.net/2440/19548.

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Bibliography: leaves 217-244.<br>x, 246 leaves : ill. (chiefly col.) ; 30 cm.<br>Tachykinins are implicated in the mediation of airway inflammatory responses and may have roles in airway remodeling and healing. The actions of tachykinins are mediated by specific receptors, designated NK1, NK2 and NK3. Tachykinin degredation, an important mechanism for limiting the effects of these peptides, is principally mediated by neutral endopeptidase (NEP). This thesis investigates the role of tachykinins, in vivo, in an ovine model and in human airway epithelium. Results show that the nett effect of tach

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Yang, Ming. "Molecular mechanisms regulating eosinophil migration and airways hyperreactivity in mice." Phd thesis, 2003. http://hdl.handle.net/1885/148761.

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