Academic literature on the topic 'Inflammatory Fibrous Hyperplasia'

BACKGROUND: Inflammatory fibrous hyperplasia associated with the use of removable dental prosthesis (IFH) is an adaptive lesion caused by long-term trauma exerted by a poorly adapted removable prosthesis on the oral mucosa, usually in the vestibular sulcus. Its diagnosis and treatment is imperative, due to its potential to cause discomfort to the patient, altering aesthetics, phonectics and chewing. CASE REPORTS: A 41-year-old denture wearer woman was referred due to discomfort in the right lower vestibular sulcus, the clinical examination showed a bilobed enlargement with an invagination where the edge of the prosthesis fits, the patient has worn the prosthesis for 15 years. EVOLUTION: Resection with scalpel (conventional technique) was performed. The histopathological examination reported inflammatory fibrous hyperplasia and a new total removable bimaxillary prosthesis was made for the patient. CONCLUSIONS: HFI is one of the main oral lesions in older adults denture wearers and it causes aesthetic and functional alterations; it is produced by the constant irritation caused by the settlement of the prosthesis borders on the mucovestibular sulcus as a consequence of alveolar resorption. Treatment is meant to eliminate the injury and its etiology; the absence of lesions on the mucosa and the bottom of the sulcus is completely necessary.

Abstract Aim The purpose of this report is to present a case of surgical and prosthetic treatment of a woman with inflammatory fibrous hyperplasia (IFH) and her evaluation during a six month period. Background IFH is a benign pathology, prevalent in female patients, and principally associated with ill-fitting prosthetic devices in need of adjustment. It is common for patients to require surgical removal of the hyperplastic tissue and fabrication of a new prosthesis. Case Report A 55-year-old female with a history of smoking presented with a chief complaint of missing the scheduled adjustment of her maxillary complete denture and the presence of moveable tissue under the denture. Surgical excision of the hyperplastic tissue followed with fixation of the prosthesis for six months to guide the healing of the soft tissue and to reshape the contours of the maxillary supporting tissues. Summary Surgical removal of hyperplasic soft tissue is a routine procedure, and the fixation of the prosthesis for the support of tissue during healing improves intraoral conditions for the fabrication of a new prosthesis in the future. Citation Jaimes M, Muñante J, Rodriguez-Chessa JG, Olate S, de Albergaria-Barbosa JR, Mazzonetto R, Klüppel LE. Inflammatory Fibrous Hyperplasia Treated with a Modified Vestibuloplasty: A Case Report. J Contemp Dent Pract 2008 March; (9)3:135-141.

Gingival enlargement, the currently accepted terminology for an increase in the size of the gingiva, is a common feature of gingival disease. Local and systemic factors influence the gingival conditions of the patient. These factors results in a spectrum of diseases that can be developmental, reactive and inflammatory to neoplastic. In this case report, the history, etiology, clinical features, treatment strategies and preventive protocol of inflammatory hyperplasia are discussed.

ABSTRACT Benign fibrous overgrowths are often found in the oral cavity. Majority of the fibromas occurring in the oral cavity are reactive in nature and represent inflammatory hyperplasia of fibrous connective tissue in response to local irritation or trauma rather than being a true neoplasm. True fibroma of the oral mucosa is an extremely rare benign neoplasm, only a few cases have been reported in the literature so far. Here, we report an exceptional case of relatively large true fibroma on the palate in an 80-yearold male patient, which was mimicking a hemangioma, not reported earlier in the literature. How to cite this article Jain M. True Fibroma on the Palate: A Unique Case. Int J Experiment Dent Sci 2016;5(1):69-71.

In the oral cavity, fibroma is the most common type of connective tissue tumor. The size of these proliferative benign connective tissue tumors varies from tiny to large, contingent upon the degree of presence of one or more components of the inflammatory response. They are usually asymptomatic.It is a locally confined hyperplasia of fibrous connective tissue brought on by persistent inflammation or local trauma. This lesion is more typically observed in men, with a preference for buccal mucosa, labial mucosa, and tongue . This lesion preferentially affects the tongue, buccal mucosa, and labial mucosa. A traumatic or irritating fibroma develops from an inflammatory hyperplastic lesion that can occur at any age and in almost any soft tissue location.

Inflammatory fibrous hyperplasia or fissured epulis is a very common lesion in patients who use maladapted removable prostheses. It consists of a connective tissue overgrowth as a response to constant trauma in a specific area. Clinically, it is presented as an exophytic process or a well-defined elevation. It is generally, sessile-based and asymptomatic. Its consistency varies from firm to flaccid, with smooth surface or occasionally ulcerated, and its color is similar to the adjacent mucosa or erythematous. The most recommended treatment is surgical removal, however there are other methods such as cryotherapy, micro-abrasion and laser therapy. The aim of this work is to describe the stages of diagnosis and treatment, from the surgical technique for removing inflammatory fibrous hyperplasia to the patient's rehabilitation, with new prostheses. This is a case report of a 79-year-old female patient who attended the clinic at Faculdade Patos de Minas (FPM) reporting dissatisfaction with the loss of lip support and the aesthetics of her complete denture prosthetics. During the clinical examination, a nodular tissue growth was identified in the bottom region of the anterior maxillary vestibule’s sac. As a proposed treatment, an excisional biopsy was performed, confirming the diagnosis of inflammatory fibrous hyperplasia through histopathological analysis. After healing, new prostheses were produced, intending to meet the patient's requirements. The present study is expected to emphasize the importance of a thorough clinical examination, so that all changes in the patient are identified and, when necessary, perform a biopsy and histopathological analysis. In summary, it is essential to adjust or produce new prosthetic parts to prevent tissue trauma or cause negative consequences. The patient's postoperative period was uneventful, with favorable healing, and after the new prosthetic devices were put in place, function and aesthetics were restored.

Fibrous histiocytoma, as the name suggests, is a lesion which is prominently composed of a combination of fibroblastic & histiocytic cells. Fibrous histiocytoma can usually be seen as either cutaneous types or involving deep tissues. The diagnosis of fibrous histiocytoma is only confirmed after surgical excision. It is imperative to differentiate this lesion from the other aggressive forms of fibrohistiocytic neoplasms. Atypical Fibrous Histiocytoma (AFH) comes in the spectrum of fibrous histiocytic lesion ranging from benign to malignant lesions. Atypical Fibrous Histiocytoma in oral cavity is distinctly uncommon. This uncommon occurrence of the lesion needs to be made known of, to prevent inappropriate treatment. Hence, here we present an uncommon case report of Atypical oral fibrous histiocytoma which presented clinically as epulis fissuratum/ Inflammatory fibrous hyperplasia

The benign and exophytic-looking irritation fibroma, also known as traumatic fibroma, is a frequent oral lesion. It can appear at any age and develops as a result of tissue damage. It is the final result of the inflammatory hyperplastic lesion after healing. The buccal mucosa, any soft tissue location, tongue, and gingiva are the most often affected sites. There is a preference for women. The preferred course of treatment for this reactive lesion is surgical excision. The purpose of this case report is to describe a benign lesion in a 54-yearold female patient who visited the department complaining of pain and swelling around the right upper front tooth for five months. Upon examination, the lesion was found to be well-circumscribed, smooth, firm, and reddish pink swelling measuring 0.5cmX0.5cm in the area of the right canine and premolar. Using a diode laser, the lesion was removed. One month after surgery, there was no sign of a recurrence. As it clinically mimics numerous illnesses including peripheral giant cell granuloma, pyogenic granuloma, or odontogenic tumours, histopathol

Gingival enlargements are quite common and may be either inflammatory, noninflammatory, or a combination of both. Gingival hyperplasia is a bizarre condition causing esthetic, functional, psychological, and masticatory disturbances of the oral cavity. Causes of gingival enlargement can be due to plaque accumulation, due to poor oral hygiene, inadequate nutrition, or systemic hormonal stimulation (Bakaeen and Scully, 1998). It can occur as an isolated disease or as part of a syndrome or chromosomal abnormality. A progressive fibrous enlargement of the gingiva is a facet of idiopathic fibrous hyperplasia of the gingiva (Carranza and Hogan, 2002; Gorlin et al., 1976). It is described variously asfibromatosis gingivae, gingivostomatitis, hereditary gingival fibromatosis, idiopathic fibromatosis, familial elephantiasis,anddiffuse fibroma. We present a case of idiopathic gingival fibromatosis with its multidisciplinary approach of management.

O objetivo do presente trabalho é analisar os componentes celulares e de fibras do tecido conjuntivo nas hiperplasias inflamatórias (HI), nos fibromas (F) e na fibromatose gengival hereditária (FGH), além de investigar a imunocompetência e efetuar análises moleculares de pacientes com FGH. Para atingir os objetivos foram desenvolvidos 4 artigos, com diferentes metodologias e universos amostrais. No 1º artigo, pretendeu-se estabelecer critérios microscópicos válidos para diferenciar F e HI. Foram avaliadas em microscópio óptico 136 lesões coradas pela Hematoxilina-eosina (HE) e pelo Tricrômico de Masson quanto às características microscópicas. Os resultados mostraram que uma área central de fibras colágenas dispostas de forma enovelada e mais densa, circundada por uma camada de fibras dispostas de forma paralela são características dos F, enquanto a presença de hiperplasia epitelial, infiltrado inflamatório e fibras colágenas organizadas de forma paralela são características das HI. Tais resultados motivaram o 2º artigo, no qual estudamos 18 lesões de F e 13 de HI, que foram preparadas histologicamente e coradas pelo picrosírius red e pelo direct blue para avaliação quantitativa das fibras colágenas e de fibras do sistema elástico, respectivamente, em microscopia a laser confocal. Os resultados confirmaram a disposição estrutural das fibras colágenas observada no 1º artigo, além de apontarem diferenças nas áreas ocupadas pelas fibras colágenas em todas as regiões estudadas. A fim de proceder a uma avaliação dos componentes fibroso e celular das 3 lesões fibrosas, foi desenvolvido o 3º artigo. Espécimes das 3 lesões foram estudados em microscopia ótica, a fim de avaliar suas populações de fibroblastos e de células inflamatórias e os seguintes componentes fibrosos do tecido conjuntivo: fibras colágenas, sistema de fibras elásticas, fibras reticulares e fibras oxitalânicas. Os resultados mostraram disposição e concentração diferente das fibras colágenas nas 3 lesões e uma maior concentração de fibras reticulares na FGH. A análise dos componentes celulares mostrou um maior número de fibroblastos no F e uma maior contagem de células inflamatórias na HI. A partir do encaminhamento de uma família com FGH, optouse por inclui-la no estudo, tendo em vista serem lesões do mesmo grupo. Com isso, foi desenvolvido um 4º estudo, que utilizou uma avaliação morfológica semelhante à dos 2 artigos anteriormente descritos. Dos pacientes com FGH foi obtido sangue periférico para avaliação da proliferação celular de linfócitos através do teste do MTT e para o sequenciamento do gene SOS-1. Os resultados mostraram hiperplasia epitelial na porção externa da gengiva dos pacientes com FGH, maior concentração de fibras colágenas e poucas células inflamatórias. Os 3 pacientes com FGH não mostraram diferenças no seu índice de proliferação de linfócitos em relação aos controles e não apresentaram a mutação descrita no gene SOS-1 de outras famílias com FGH. Pode se concluir que as 3 lesões apresentam estrutura conjuntiva diferente tanto no aspecto quantitativo quanto na disposição estrutural de seus componentes.<br>The objective of this study was to analyze the cellular and fibrous components of connective tissue in inflammatory hyperplasia (IH), oral fibroma (OF) and hereditary gingival fibromatosis (HGF), and to investigate the immunocompetence and to perform molecular analysis in HGF patients. To achieve the goals were developed 4 articles, with different methodologies and sample universes. In the 1st article, we intended to establish microscopic criteria to differentiate F and IH. The microscopic characteristics of the lesions (n=136) stained by hematoxylin-eosin (HE) and Masson trichrome were evaluated in an optical microscope. The results showed that a central area of wound collagen fibers and arranged in a higher density, surrounded by a layer of parallel fibers are characteristic of F, while the presence of epithelial hyperplasia, inflammatory infiltrate and parallel collagen fibers are characteristics of HI. These results led the 2nd article, which studied 18 F and 13 and IH, histologically prepared and stained by picrosírius red and direct blue for the direct quantitative assessment of collagen fibers and elastic fibers of the system, respectively, in the confocal laser microscope. The results confirmed the structural arrangement of collagen fibers found in Article 1, and indicate differences in the areas of collagen fibers in all regions studied. In order to evaluate the cellular and fibrous components of the 3 fibrous lesions, was developed the 3rd article. Specimens of the 3 lesions were studied in optical microscopy, to assess their populations of fibroblasts and inflammatory cells and the following components of fibrous connective tissue: collagen fibers, elastic fiber system, reticular fibers and oxytalan fibers. The results showed different arrangement and concentration of collagen fibers in the 3 lesions and a higher concentration of reticular fibers in HGF. The analysis of cellular components showed a greater number of fibroblasts in F and a higher count of inflammatory cells in IH. With the identification of a family with HGF, we chose to include it in the study because the lesions belong to the group of benign fibrous lesions. With that, it developed a 4th study, which used a similar morphologic evaluation of the 2 articles described above. Periferic blood was extracted from the HGF patients in order to determine the proliferative capacity of the peripheral lymphocytes, by the MTT test, and in order to sequence the SOS1 gene. The 3 HGF affected patients did not present the described mutation for the SOS1 gene, and the lymphocyte proliferative capacity in HGF patients was similar to those on controls. The results showed epithelial hyperplasia in the outer portion of the gingiva of patients with HGF, greater concentration of collagen fibers and few inflammatory cells. We can conclude that the 3 lesions present a different connective structure, considering both the quantitative aspect and the architectural disposition of their components.

Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent arterial or venous thrombosis and/or pregnancy loss, accompanied by laboratory evidence of antiphospholipid antibodies (aPL), namely anticardiolipin antibodies (aCL), lupus anticoagulant (LA), and antibodies directed against beta-2 glycoprotein 1 (β‎‎‎2GP1). APS may occur as a ‘primary’ form, ‘antiphospholipid syndrome,’ without any known systemic disease or may occur in the context of systemic lupus erythematosus (SLE), ‘SLE-related APS’. APS may affect any organ system and displays a broad spectrum of thrombotic manifestations, ranging from isolated lower extremity deep vein thrombosis to the ‘thrombotic storm’ observed in catastrophic antiphospholipid syndrome. Less frequently, patients present with non-thrombotic manifestations (e.g. thrombocytopaenia, livedo reticularis, pulmonary hypertension, valvular heart disease, chorea, and recurrent fetal loss).The kidney is a major target organ in both primary and SLE-related APS. Renal involvement is typically caused by thrombosis occurring at any location within the renal vasculature, leading to diverse effects, depending on the size, type, and site of vessel involved. The renal manifestations of APS include renal artery stenosis and/or renovascular hypertension, renal infarction, APS nephropathy (APSN), renal vein thrombosis, allograft vasculopathy and vascular thrombosis, and thrombosis of dialysis access.Typical vascular lesions of APSN may be acute, the so-called thrombotic microangiopathy, and/or chronic, such as arteriosclerosis, fibrous intimal hyperplasia, tubular thyroidization, and focal cortical atrophy. The spectrum of renal lesions includes non-thrombotic conditions, such as glomerulonephritis. Furthermore, renal manifestations of APS may coexist with other pathologies, especially proliferative lupus nephritis.Early diagnosis of APS requires a high degree of clinical suspicion. The diagnosis requires one clinical (vascular thrombosis or pregnancy morbidity) and at least one laboratory (LA, aCL, and/or anti-β‎‎‎2GP1) criterion, positive on repeated testing.The aetiology of APS is not known. Although aPL are diagnostic of, and pathogenic in, APS, a ‘second hit’ (usually an inflammatory event) may trigger thrombosis in APS. The pathogenesis of the thrombotic tendency in APS remains to be elucidated, but may involve a combination of autoantibody-mediated dysregulation of coagulation, platelet activation, and endothelial injury.Treatment of APS remains centred on anticoagulation; however, it has also included the use of corticosteroids and other immunosuppressive therapy. The prognosis of patients with primary APS is variable and unpredictable. The presence of APS increases morbidity (renal and cerebral) and mortality of SLE patients.

The oral tissues, for obvious anatomical reasons, are exposed to continuous mechanical and inflammatory traumatic insults. Both reactive and pure traumatic hyperplastic injuries have been dealt with in this chapter. Reactive hyperplastic lesions are tumor-like hyperplasias caused by a tumor-like non-neoplastic proliferation due to chronic irritative stimuli. The most common reactive lesions include morsicatio labiorum, buccarum and traumatic fibroma. Among the purely traumatic ones, hematoma, ecchymosis and mucocele (affecting the minor salivary glands) stand out. These lesions can be generalized to large areas of the mucous membrane of the oral cavity or localized as solitary neoformations. Furthermore, according to the clinical aspect, they can be divided into plain (e.g., keratosis), exophytic (e.g., mucocele and fibroma) and endophytic (e.g., traumatic ulcers). Reactive traumatic injuries often present diagnostic challenges because they mimic other pathologies of a non-traumatic nature.

Introduction: The risk of breast cancer in transgender men is similar to that of cisgender women. The average age at diagnosis is 44 years, suggesting an early incidence with greater tumor aggressiveness. It commonly presents as a palpable mass, years after masculinizing mastectomy, and has a histological subtype of invasive ductal carcinoma and luminal molecular subtype. Although there are no screening and treatment protocols for these cases, similar follow-up to CIS is recommended, including mastectomy, hormone therapy, radiotherapy and chemotherapy. Case report: Patient, 42 years old, woman, transgender, nulliparous, no use of hormones, presented to an appointment asking for aesthetic mastectomy. She reported a family history of aunt and two cousins with breast cancer and a 32 year-old sister with atypical ductal hyperplasia. She identified a mass in the superolateral quadrant of the left breast through self-examination of the breasts. The mammography showed dense breasts, BIRADS 0. Breast ultrasound resulted in a solid, hypoechoic nodule, irregularly contoured, microlobulated, measuring 1.1x0.6 cm, between 2h and 3h, and about 3 cm from the areola of the left breast and BIRADS 5. Resonance imaging showed this hypointense nodule with lobulated contours measuring 1.3 x 0.6 cm, 3.3 cm from the nipple and 1.7 cm from the pectoral muscles. USG-guided thick needle biopsy diagnosed IDC (Invasive ductal carcinoma), histological grade 2, nuclear grade 3, with moderate stromal fibrosis, severe stromal elastosis, mild lymphocytic inflammatory infiltratation and vascular invasion present. It was 100% positive estrogen receptor and 50% positive progesterone receptor, with 12% Ki67 and negative HER-2, luminal molecular subtype A at immunohistochemistry. A bilateral skin and papillary areolar complex saving mastectomy was performed with sentinel node biopsy on the left. Anatomopathological examination showed absence of metastatic neoplasia in the lymph nodes and left breast with IDC in the retroareolar region, with the same characteristics as the previous biopsy. Pathological staging was T1N0M0 and anatomical staging and pathological prognosis was Ia. Oncotype DX Recurrence Score test was equal to 26. The patient was subjected to six cycles of Taxotere plus Cyclophosphamide and is using Tamoxifen and hormone with Androgel. We report a case of subcutaneous mastectomy used in an innovative way with preservation of the areola-papillary complex (APC), with an aesthetic contour of the chest wall and adjustment of the APC, allowing greater satisfaction in the experience of the genus. The same breast pathology that occurs in women should be expected in transgender women. So, we must consider that the focus on the aesthetic result may result in less precaution with the thickness of the remaining dermogreasy flap, with residual breast glandular tissue, and a higher risk of breast cancer.