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Journal articles on the topic 'Inflammatory Nasal Polyp'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Kim, Si-Yeon, Jun Yeong Hong, Sang-Jun Na, and Soo Hwan Yim. "Recurrent Bacterial Meningitis Associated with Inflammatory Nasal Polyp." Journal of the Korean Neurological Association 40, no. 3 (2022): 247–50. http://dx.doi.org/10.17340/jkna.2022.3.6.

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In case of no head trauma history and intact immunity, adultonset recurrent bacterial meningitis is scarce. Parameningeal infection is the crucial latent cause of recurrent bacterial meningitis in adults. Nasal polyp can cause a variety of nasal symptoms, depending on its location and size. Chronic sinusitis with nasal polyp tends to have more severe symptoms than those without nasal polyp. We report a case of adult onset third recurrent bacterial meningitis associated with inflammatory nasal polyp.

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2

International, Journal of Medical Science and Innovative Research (IJMSIR). "Sinonasal polyp with osseous metaplasia – A rare case with review of literature." International Journal of Medical Science and Innovative Research (IJMSIR) 9, no. 3 (2024): 16–18. https://doi.org/10.5281/zenodo.15401834.

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<strong>Abstract</strong> Inflammatory nasal polypsare quite rare arising from the nasal septum especially with osseous metaplasia. They can extent to the oropharynx, when they are larger in size. We report a case of inflammatory nasal polyp arising from the nasal septum showing osseous metaplasia in a 65year old male patient. Thepolyp was larger in size extending into oropharynx, which resulted in difficulty in swallowing along with nasal obstruction. Surgical excision was done and histopathological examination proved it to be inflammatory nasal polyp with osseous metaplasia.

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Fernández-Bertolín, L., J. Mullol, I. Alobid, J. Roca-Ferrer, C. Picado, and L. Pujols. "Impact of cell culture methods on the outcomes of the in vitro inflammatory response in nasal polyps." Rhinology journal 49, no. 5 (2011): 562–69. http://dx.doi.org/10.4193/rhino11.036.

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Background: In vitro culture of nasal polyp cells is frequently used in the investigation of inflammatory mechanisms and effect of treatments in nasal polyposis. Research outcomes may, however, be influenced by the culture methodology used. Methods: Nasal polyp and nasal mucosa in vitro fibroblast cultures were pre-treated with foetal bovine serum (FBS)-free culture medium or medium supplemented with either FBS or charcoal-stripped (cs) FBS. Cells were then stimulated with FBS or csFBS, with or without different doses of dexamethasone for 4 and 24h. IL-6, IL-8, GM-CSF and VEGF release and cell

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4

Jitendra Pratap Singh Chauhan, Ritu Gupta, and Abhay Kumar. "Nasal polyps and its histopathological classification: A retrospective study." Asian Journal of Medical Sciences 14, no. 8 (2023): 164–69. https://doi.org/10.71152/ajms.v14i8.3682.

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Background: The diagnosis of nasal polyp is made according to clinical and radiological criteria, while histopathologic examination is important for an accurate diagnosis. Histological classification of nasal polyps and its clinical implications are very rarely reported in the literature. Aims and Objectives: The aim of this study was to study clinical presentation and site of occurrence of nasal polyps and histologically classify nasal polyps in relation to studies published in the literature. We classified the histological changes as described by Davidson and Hellquist. Materials and Methods

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Jitendra Pratap Singh Chauhan, Ritu Gupta, and Abhay Kumar. "Nasal polyps and its histopathological classification: A retrospective study." Asian Journal of Medical Sciences 14, no. 8 (2023): 164–69. http://dx.doi.org/10.3126/ajms.v14i8.52615.

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Background: The diagnosis of nasal polyp is made according to clinical and radiological criteria, while histopathologic examination is important for an accurate diagnosis. Histological classification of nasal polyps and its clinical implications are very rarely reported in the literature. Aims and Objectives: The aim of this study was to study clinical presentation and site of occurrence of nasal polyps and histologically classify nasal polyps in relation to studies published in the literature. We classified the histological changes as described by Davidson and Hellquist. Materials and Methods

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Sofyan, Ferryan, Delfitri Munir, Imam Budi Putra та ін. "Effect of Thymoquinone and Transforming Growth Factor-β1 on the Cell Viability of Nasal Polyp-Derived Fibroblast". Open Access Macedonian Journal of Medical Sciences 10, B (2022): 1392–98. http://dx.doi.org/10.3889/oamjms.2022.9516.

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BACKGROUND: Nasal polyps are benign masses in the nasal cavity and the abnormal growth of sinonasal tissue due to a chronic inflammatory process. Many fibroblasts populate the nasal polyp stroma release cytokines such as Transforming Growth Factor (TGF) and producing a variety of cytokines resulting in inflammatory cell infiltration. Thymoquinone (TQ) is the main active component in Nigella sativa oil and has the ability to reduces cell viability in many cancer cell line. AIM: The purpose of this study was to determine the effect of TQ and TGF-β1 on cell viability of Nasal Polyp-Derived Fibrob

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Rizzi, Angela, Luca Gammeri, Raffaele Cordiano, et al. "Therapeutic Strategies to Prevent the Recurrence of Nasal Polyps after Surgical Treatment: An Update and In Vitro Study on Growth Inhibition of Fibroblasts." Journal of Clinical Medicine 12, no. 8 (2023): 2841. http://dx.doi.org/10.3390/jcm12082841.

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Chronic rhinosinusitis with nasal polyps (CRSwNP) is the most bothersome phenotype of chronic rhinosinusitis, which is typically characterized by a Type 2 inflammatory reaction, comorbidities and high rates of nasal polyp recurrence, causing severe impact on quality of life. Nasal polyp recurrence rates, defined as the number of patients undergoing revision endoscopic sinus surgery, are 20% within a 5 year period after surgery. The cornerstone of CRSwNP management consists of anti-inflammatory treatment with local corticosteroids. We performed a literature review regarding the therapeutic stra

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Narzary, Musuka G., Prakash Saikia, Kathiravan G, et al. "Unilateral nasal mass beyond 4th decade: A comprehensive clinicopathological study." IP Journal of Otorhinolaryngology and Allied Science 7, no. 4 (2024): 74–78. https://doi.org/10.18231/j.ijoas.2024.019.

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Unilateral nasal mass may be a common presentation in children and young adults, and the majority of them are inflammatory polyps. But as the age advances, unilateral nasal complaints should alert the physician to the possibility of an underlying neoplastic mass lesion. To study the etiopathology and clinical features of unilateral nasal mass in patients above 40 years of age. The study was conducted in the department of otorhinolaryngology, Tezpur Medical College & Hospital. A total of 27 patients with unilateral nasal mass who are above 40 years of age are included in the study. The clin

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Radhika, S., Selva Guru Lakshmi, M. Saranya, and Rajalakshmi Preethi G. "Atypical stromal cells, a pseudosarcomatous change in sinonasal polyp causing diagnostic dilemma - A case report and review of literature." IP Journal of Diagnostic Pathology and Oncology 9, no. 4 (2024): 230–33. https://doi.org/10.18231/j.jdpo.2024.047.

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Nasal polyposis is a commonly encountered non-neoplastic inflammatory disease of the nose and paranasal sinuses presenting with various clinical manifestations like nasal obstruction, rhinorrhea, headache, anosmia/hyposmia, etc. The two most common etiologies of nasal polyps includes allergy and infections. The incidence of nasal polyposis in the general population is 0.5 to 4%. The histological diagnosis of benign inflammatory polyps of the nasal cavity usually doesnot pose any diagnostic difficulties. However, certain unusual histological features can be observed rarely which might be a huge

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Kamarudin, Intan Kartika, and Noor Shahira Mohamad Fuzi. "Nasal Polyposis Showing Aggressive Behaviour – Inflammatory or Inverted Papilloma?" International Journal of Human and Health Sciences (IJHHS) 8, no. 20 (2024): 56. http://dx.doi.org/10.31344/ijhhs.v8i20.702.

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Nasal polyposis affects 0.2-1% of the general population. Inflammatory nasal polyp rarely behaves aggressively causing expansion to the surrounding structures without evidence of invasion. We report a case of an aggressive nasal polyp which was mistaken for inverted papilloma. A 48-year-old gentleman with underlying ischemic heart disease on aspirin presented with one month history of progressive left nasal block. He started to have frequent sneezing triggered by exposure to cold and dust. He had unilateral left straw-coloured rhinorrhea which was copious, and he was treated with oral antibiot

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Bolk, Kody G., and Sarah K. Wise. "Biologic Therapies across Nasal Polyp Subtypes." Journal of Personalized Medicine 14, no. 4 (2024): 432. http://dx.doi.org/10.3390/jpm14040432.

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Chronic rhinosinusitis with nasal polyposis is a common inflammatory condition, with subtypes like aspirin-exacerbated respiratory disease, allergic fungal rhinosinusitis, and central compartment atopic disease sharing a common type 2 inflammatory pathway. Respiratory biologic therapies have been developed that target type 2 inflammation. In this article, we discuss the use of respiratory biologic therapies for nasal polyposis in general, as well as within the various subtypes of nasal polyps. Further, we discuss future roles of novel biologic therapies targeting type 2 inflammation in nasal p

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Karthikeyan, Padmanabhan, Sneha Mary Joy, Davis Thomas Pulimootil, and Neelima Vijayan. "Bleeding angiomatous polyps of the maxillary sinus: Review of literature and a rare case report." Romanian Journal of Rhinology 9, no. 35 (2019): 145–49. http://dx.doi.org/10.2478/rjr-2019-0017.

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Abstract ENT surgeons frequently encounter a variety of neoplastic, non-neoplastic and inflammatory masses involving the nasal cavity, the paranasal sinuses or the nasopharynx. Among these, the angiomatous polyp or angiectatic nasal polyps are rare and account for 4-5% of all inflammatory nasal polyps. They have variable growth patterns and clinical features. In angiomatous nasal polyps, there is a prominent component of dilated capillary-type blood vessels. We present a review of the literature regarding the most important features of this pathology and an unusual case of a large angiomatous

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Miller, Chase H., Deborah R. Pudiak, Fadi Hatem, and Richard J. Looney. "Accumulation of Interferon Gamma-Producing TH1 Helper T Cells in Nasal Polyps." Otolaryngology–Head and Neck Surgery 111, no. 1 (1994): 51–58. http://dx.doi.org/10.1177/019459989411100111.

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We investigated the mechanisms involved in the formation of nasal polyps by examining T-cell clones and their production of soluble mediators in nasal polyps. Recently, the allergic origin of nasal polyps has been challenged. To study this question we characterized T cells from polyp tissue of allergic individuals in terms of their cytokine pattern. Nasal polyp T cells were cloned from allergic individuals undergoing polypectomy. Polyp tissue was dispersed enzymatically, and T cells were stimulated with mitogen and interleukin-2. Control T cells were obtained from peripheral blood of nonallerg

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Dhingra, Preeti, Naresh Palapalle, Dilroop K. Poyyil, and Rakesh Katna. "Sinonasal angiomatous polyp: a case report." International Journal of Otorhinolaryngology and Head and Neck Surgery 8, no. 12 (2022): 1000. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20223052.

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<p>Sinonasal angiomatous polyp (SAP) is a rare variant of sino-nasal polyp. Sinonasal inflammatory polyps are classified histo-pathologically into 5 types: edematous, glandular, fibrous, cystic and angiomatous. They present with various different patterns and clinical features like epistaxis, nasal discharge, nasal blockage and characterised histo-pathologically by presence of prominent dilated capillary-type blood vessels. It constitutes about 4-5% of all nasal polyps. They usually present as a unilateral, painless, soft, gelatinous, translucent and polypoidal mass in nasal cavity. Thes

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15

Naik, Mahendra S., and Sulabha M. Naik. "An Unusual Presentation of Nasal Polyp Arising from Floor of Nasal Cavity." An International Journal of Otorhinolaryngology Clinics 3, no. 2 (2011): 129–31. http://dx.doi.org/10.5005/jp-journals-10003-1071.

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ABSTRACT Introduction Nasal polyps are pedunculated, edematous, prolapsed mucosa of the paranasal sinuses. These polyps commonly arise around the ostia of the paranasal sinuses in the middle meatus. Discussion The commonest sites of polyp formation are the ethmoid sinuses and maxillary sinus. Rarely polyps may also arise from the other paranasal sinuses. Sites in the nasal mucosa other than the paranasal sinuses are very rare, though polyps arising from the septum have also been reported. The etiology of nasal polyposis is believed to be due to an inflammatory reaction of the nasal and paranas

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16

Bernstein, Joel M., Janet Gorfien, and Bernice Noble. "Role of Allergy in Nasal Polyposis: A Review." Otolaryngology–Head and Neck Surgery 113, no. 6 (1995): 724–32. http://dx.doi.org/10.1016/s0194-59989570012-9.

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We propose a multivariate theory for the pathogenesis of nasal polyps. Turbulent flow of air in the lateral wall of the nose or viral-bacterial-host interactions produce an inflammatory change in the mucosa of the lateral wall of the nose. Ulceration and prolapse of the submucosa with reepithelialization and new gland formation may then follow. The structural cells of the nasal polyp, including epithelial cells and fibroblasts, have the ability to produce messenger RNA for granulocyte-monocyte colony-stimulating factor and other cytokines. Stimulation of such an effector capability by structur

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Sukhachev, P. A., O. S. Sergeev, I. O. Prokhorenko, and M. I. Panina. "MORPHOLOGY OF NASAL POLYPS IN PATIENTS WITH ALTERED IMMUNOLOGICAL REACTIVITY." Morphological newsletter 25, no. 4 (2017): 22–26. http://dx.doi.org/10.20340/mv-mn.2017(25).4.22-26.

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Morphological-functional characteristics of nasal polyps were studied in 88 patients with rhinosinusitis polyps. The tissue of a polyp had typical picture, multi-rows ciliated epithelium with a large number of goblet celts. Different stages of polyp maturation were observed: from edematous to perivascular and diffuse cellular infiltrates consisting of eosinophils, lymphocytes and mast cells. Their presence proves allergic nature of rhinosinusitis, which as any pathology process by stress is accompanied. At the early stage, chronic stress downregulate pro-inflammatory cytokines, while upregulat

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18

Huriyati, Effy, Eryati Darwin, Yanwirasti Yanwirasti, and Irza Wahid. "Differences in Expression of Inflammatory Mediator in Mucosal and Polyp Tissue between Chronic Rhinosinusitis and Recurrent Chronic Rhinosinusitis." Open Access Macedonian Journal of Medical Sciences 7, no. 11 (2019): 1733–38. http://dx.doi.org/10.3889/oamjms.2019.341.

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BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) remains a challenging clinical entity with its propensity for recurrence. This disease decreases the patients’ quality of life and creates a high economic burden. An effort to investigate the aetiology of recurrent polyps have to be more alert. AIM: This study aims to prove the differences in expression of IL-5, IL-8, IL-17A and TGF-β1 in mucosal and polyp tissue between CRSwNP and recurrent CRSwNP and also to determine which expression of cytokines that have the main role in mucosal and polyp tissue in recurrent CRSwNP.

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Pavlush, D. G., and I. V. Dyuizen. "Inflammatory markers in the nasal mucosa and polyp-modified tissues in chronic rhinosinusitis with nasal polyps." CLINICAL AND EXPERIMENTAL MORPHOLOGY 10, no. 3 (2021): 29–38. http://dx.doi.org/10.31088/cem2021.10.3.29-38.

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Introduction. To date, chronic rhinosinusitis with nasal polyps (CRSwNP) has not yet been extensively studied: the molecular factors and mechanisms involved in the initiation of polypous transformations in nasal mucosa (NM) and sustaining their recurrence probability are still to be determined. Simultaneously, it is necessary to understand the molecular rearrangement in NM tissues to make clinical prognosis and choose an adequate therapeutic or surgical strategy for CRSwNP treatment. The aim of the study was to identify the features of how inflammatory markers localize and are distributed in t

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Pavlush, D. G., and I. V. Dyuizen. "Inflammatory markers in the nasal mucosa and polyp-modified tissues in chronic rhinosinusitis with nasal polyps." CLINICAL AND EXPERIMENTAL MORPHOLOGY 10, no. 3 (2021): 29–38. http://dx.doi.org/10.31088/cem2021.10.3.29-38.

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Introduction. To date, chronic rhinosinusitis with nasal polyps (CRSwNP) has not yet been extensively studied: the molecular factors and mechanisms involved in the initiation of polypous transformations in nasal mucosa (NM) and sustaining their recurrence probability are still to be determined. Simultaneously, it is necessary to understand the molecular rearrangement in NM tissues to make clinical prognosis and choose an adequate therapeutic or surgical strategy for CRSwNP treatment. The aim of the study was to identify the features of how inflammatory markers localize and are distributed in t

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Khairunnisa, Salma Yuri, Tofrizal Tofrizal, and Netti Suharti. "Hubungan Jumlah Eosinofil dengan Ukuran Polip Nasal dan Karakteristik Pasien yang Didiagnosis di Sentra Diagnostik PA FK-UNAND Tahun 2017-2019." Jurnal Ilmu Kesehatan Indonesia 2, no. 1 (2021): 33–40. http://dx.doi.org/10.25077/jikesi.v2i1.291.

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 Background: Nasal polyps is a soft masses filled with fluid in nasal mucosa. The incidence is not high, but nasal polyps are related with inflammatory process. Factors that can affect nasal polyps are eosinophils, polyp size, age and gender of the patient. Objective: This study aims to discuss the association between eosinophils with polyp size, age and gender of polyp patient. Methods: The type of this study was an analytic using a cross sectional approach. This research took place from February- October 2020 in the Pathology Anatomy Diagnostic Central of Faculty of Medicin

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Shin, Seung-Heon, Mi-Kyung Ye, Dong-Won Lee, and Mi-Hyun Che. "Effect of Acacia Honey on Transforming Growth Factor-Beta-1-Induced Myofibroblast Differentiation and Matrix Metalloproteinase-9 Production in Nasal Polyp Fibroblasts." American Journal of Rhinology & Allergy 33, no. 5 (2019): 483–89. http://dx.doi.org/10.1177/1945892419843702.

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BackgroundAcacia honey is known to have antioxidant, immune-modulatory, and antiproliferative properties. Nasal fibroblasts participate in local immune responses that control the recruitment of inflammatory cells and the production of extracellular matrix.ObjectivesThe aim of this study was to determine the effect of acacia honey on myofibroblast differentiation and matrix metalloproteinase-9 (MMP-9) production in nasal polyp fibroblasts.MethodsPrimary nasal fibroblasts were isolated from nasal polyps and treated with transforming growth factor-beta 1 (TGF-β1). Reverse transcription-polymerase

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Tan, Bruce, Quan Li, Lydia Suh, et al. "Local autoantibodies in Chronic Rhinosinusitis (CRS) with Nasal Polyps. (48.8)." Journal of Immunology 184, no. 1_Supplement (2010): 48.8. http://dx.doi.org/10.4049/jimmunol.184.supp.48.8.

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Abstract Abstract Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory condition of the nasal passage and paranasal sinuses. It is characterized by a Th2 biased inflammatory infiltrate not currently attributed to autoimmunity. Recent studies from our laboratory demonstrate elevated levels of BAFF, B-lymphocytes, and IgA. The role of these B-cells and the specificities of the immunoglobulins produced are still unknown. Methods: Protein extracts from nasal polyps of 11 patients were compared to nasal tissue obtained from 10 normal controls using autoantibody microar

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Lo, S., S. Di Palma, E. George, and A. W. McCombe. "Immunolocalisation of heme oxygenase isoforms in human nasal polyps." Journal of Laryngology & Otology 123, no. 1 (2008): 131–35. http://dx.doi.org/10.1017/s0022215107001284.

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AbstractBackground:Carbon monoxide is an endogenous vasodilator gas produced by the enzyme heme oxygenase (HO). HO is expressed in human nasal mucosa, but its pathophysiological role in nasal inflammatory diseases is not fully understood. The aim of this study was to detect and compare the expression of HO-1 and -2 isoforms in nasal polyps with normal nasal mucosa.Methods:Immunohistochemical analysis using antibodies specific for HO-1 and -2 was conducted on nasal polyps from nine patients with allergic nasal polyposis, and on normal nasal mucosa from six controls.Results:Intense HO-1 immunore

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Yolazenia, Yolazenia, Inayah Inayah, Febri Romaito Romaito, Retni Tri Handayani, and Novisa Dwi Utami. "EOSINOPHILS PROFILE AND LUND-MACKAY SCORE OF NASAL POLYPS IN ARIFIN ACHMAD HOSPITAL, RIAU PROVINCE." Berkala Kedokteran 18, no. 1 (2022): 67. http://dx.doi.org/10.20527/jbk.v18i1.12820.

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Abstract: Theories suggest that nasal polyps occur as a result of chronic inflammation of the nasal and sinus mucosa. Eosinophils are the main inflammatory cells found in nasal polyp tissue. The severity of nasal polyps can be seen from the CT Scan of the Paranasal Sinus (PNS) using the Lund-Mackay score. The purpose of this study was to determine the description of the eosinophil count of nasal polyp tissue and the Lund-Mackay score of CT Scan PNS of nasal polyps patients in Arifin Achmad Hospital, Riau Province. Examination of the eosinophil count was carried out microscopically using histop

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H, Shah, Baviskar B. P, and Dongre S. D. "Histopathological study of non-neoplastic lesions of nose, paransal sinuses and nasopharynx." International Journal of Clinical and Biomedical Research 1, no. 1 (2019): 1–4. http://dx.doi.org/10.31878/ijcbr.2018.51.01.

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Background: The various lesions of the nose, paranasal sinuses and nasopharynx were subjected to histopathological evaluation over a period of 5 years (2010 to 2015) at the Department of Pathology, in a rural based hospital. Total 84 specimens were studied over the time of 5 years. Methodology: The formalin fixed specimens were received with complete clinical and radiological features. Routine gross examination and required number of sections were taken and stained with hematoxylin and eosin. Result: In the study, 84 cases were of Inflammatory and Non neoplastic lesions. Nasal polyps were the

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Dr., Shyam Kumar Sah, Deeraj BC Dr., and Ashwini MJ Dr. "Nasal Polyp Nasa Arsha Management Through Ayurveda A Single Case Study." International Journal of Trend in Scientific Research and Development 3, no. 4 (2019): 501–4. https://doi.org/10.31142/ijtsrd23812.

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Nasal polyp is a chronic inflammatory disease affecting about 1-4 of the general population.1 Nasal polyps are fleshy benign growth that develop in the mucosal lining of the nasal passage and paranasal sinuses. Polyps vary in size and having shining pink colour and shaped like tear drops.2,3 The exact etiology remains unclear but it is known to have associations with allergy, asthma, infection, cystic fibrosis and aspirin sensitivity. The common features of the disease are nasal obstruction, anosmia, rhinorrhoea, post nasal drip and less commonly facial pain.4 In Ayurveda it is closely related

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Lou, Hongfei, Yifan Meng, Yingshi Piao, et al. "Cellular phenotyping of chronic rhinosinusitis with nasal polyps." Rhinology journal 54, no. 2 (2016): 150–59. http://dx.doi.org/10.4193/rhino15.271.

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Background: Defining the phenotypes of chronic rhinosinusitis with nasal polyps (CRSwNP) with prognosis may lead to delivery of personalized treatment. This study aimed to identify cellular phenotypes of CRSwNP using cluster analysis and define an algorithm for different clusters associated with polyp recurrence. Methods: Overall, 366 patients with CRSwNP were enrolled in this retrospective analysis. Eighteen variables, including clinical characteristics and tissue/peripheral inflammatory cells assessments, were selected for factor analysis. Unsupervised cluster analysis was performed after va

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Bülbül, T., Ö. Gümüştekin Bülbül, O. Güçlü, A. Serpil Bilsel, and S. Önal Gürsan. "Effect of glucocorticoids on nasal polyposis, with detection of inflammatory response by measurement of nitric oxide levels in nasal polyp tissue." Journal of Laryngology & Otology 127, no. 6 (2013): 584–89. http://dx.doi.org/10.1017/s002221511300073x.

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AbstractObjective:To investigate endoscopic staging, and nitric oxide levels in the polyp tissue, in patients with nasal polyposis undergoing glucocorticoid therapy.Methods:Nasal polyposis was evaluated using endoscopic staging and measurement of polyp tissue nitric oxide levels (chemiluminescence method). Forty-five nasal polyposis patients received either nasal therapy (n = 15), oral therapy (n = 15) or combined therapy (n = 15). Pre-treatment and post-treatment staging and nitric oxide levels were evaluated.Results:Endoscopic grading indicated significant post-treatment staging improvements

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Pezato, Rogério, Danilo Cândido de Almeida, Thiago Freire Bezerra, et al. "Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment." Mediators of Inflammation 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/583409.

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Nasal polyposis is a severe, chronic inflammatory condition of the paranasal sinuses and is frequently associated with asthma and aspirin sensitivity. Mesenchymal stem cells exhibit a potent immunosuppressive effect in several inflammatory conditions, and their role in nasal polyposis remains little explored. Hence, we investigated whether bone marrow-derived mesenchymal stem cells could modulate cell phenotype in the nasal polyp milieu. After coculture with mesenchymal stem cells, the frequency of these inflammatory cells was found to decrease. Furthermore, mesenchymal stem cells promoted str

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Chiarella, Emanuela, Nicola Lombardo, Nadia Lobello, et al. "Nasal Polyposis: Insights in Epithelial-Mesenchymal Transition and Differentiation of Polyp Mesenchymal Stem Cells." International Journal of Molecular Sciences 21, no. 18 (2020): 6878. http://dx.doi.org/10.3390/ijms21186878.

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Chronic rhinosinusitis is a common inflammatory disease of paranasal sinuses, which causes rhinorrhea, nasal congestion, and hyposmia. The genetic predisposition or the exposure to irritants can sustain the inflammatory response and the development of nasal polyposis. Nasal polyps are benign and teardrop-shaped growths that project in the nasal cavities, and originate from the ethmoid sinuses. This inflammatory process is associated with high expression of IL-4, IL-5 and IL-13 and IgE. Antibodies targeting these cytokines or receptors represent a therapeutic strategy in the treatment of nasal

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Alam, Nurul, S. K. Abdullah Ahmed, Monoj K. Deka, and Shah Alam Sheikh. "Histopathological study of nasal masses, a one year retrospective study in a tertiary care centre of Assam." International Journal of Research in Medical Sciences 9, no. 4 (2021): 1122. http://dx.doi.org/10.18203/2320-6012.ijrms20211362.

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Background: Prolapsed lining of the nasal sinuses are defined as nasal polyp. Diseases of the nasal cavity include viral, bacterial and fungal infections, nasal cavity tumors (benign and malignant) as well as inflammations of the nasal mucosa. This study was undertaken to note the various histopathological patterns of nasal masses, their classification and relative distribution of various lesions with regard to age and sex in our setting.Methods: The study is done for a period of 1 year (July 2018 to June 2019). In this study, 30 patients are selected who presented in our hospital with nasal m

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Mohammad Lukmanul Hakim and Irwan Kristyono. "Chronic rhinosinusitis patient with nasal polyps at Dr. Soetomo General Academic Hospital Center." Bali Medical Journal 11, no. 2 (2022): 766–70. http://dx.doi.org/10.15562/bmj.v11i2.3628.

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Background: Nasal polyps are benign chronic inflammatory masses with epithelial tissues of the nasal mucosa and paranasal sinuses. The clinical diagnosis is made based on sinonasal symptoms for more than three months and the presence of polyps in the nasal cavity. The classification of nasal polyps based on the histopathological structure is divided into three types, i.e., oedematous, eosinophilic polyps, inflammatory polyps, and chronic seromucous inflammatory polyps. This study aims to describe the profile of patients with nasal polyps at Dr. Soetomo Public Hospital Surabaya. Methods: This s

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Priyadharshini, V. S., Marcos Alejandro Jiménez-Chobillon, Jos de Graaf, et al. "Transcriptome Analysis Identifies Doublesex and Mab-3 Related Transcription Factor (DMRT3) in Nasal Polyp Epithelial Cells of Patients Suffering from Non-Steroidal Anti-Inflammatory Drug-Exacerbated Respiratory Disease (AERD)." Biomolecules 11, no. 8 (2021): 1092. http://dx.doi.org/10.3390/biom11081092.

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Background: Aspirin-exacerbated respiratory disease (AERD) is a syndrome characterised by chronic rhinosinusitis, nasal polyps, asthma and aspirin intolerance. An imbalance of eicosanoid metabolism with anover-production of cysteinyl leukotrienes (CysLTs) has been associated with AERD. However, the precise mechanisms underlying AERD are unknown. Objective: To establish the transcriptome of the nasal polyp airway epithelial cells derived from AERD patients to discover gene expression patterns in this disease. Methods: Nasal airway epithelial cells were isolated from 12 AERD polyps and 8 AERD no

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Ekinci, Adnan, Huseyin Kayadibi, Emre Demir, and Muge Ozcan. "The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps." Turkish Journal of Biochemistry 46, no. 4 (2021): 473–77. http://dx.doi.org/10.1515/tjb-2019-0204.

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Abstract Objective To compare prolidase enzyme activity (PEA) in serum and polyp specimens of patients with nasal polyps obtained before and after the oral steroid therapy. Materials and methods Thirty three patients with nasal polyps (39 ± 13 years) received 1 mg/kg of oral steroids. Serum samples were collected from each patient, but nasal polyp specimens could be obtained only from 23 patients (38 ± 13 years) before and after the oral steroid therapy. PEA was measured by ELISA method. Results Serum PEA values were 210 (176–242) U/L and 184 (147–217) U/L before and after the oral steroid the

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Taylan, Gun. "Giant antrochoanal polyp presenting as oropharyngeal mass." Archives of Otolaryngology and Rhinology 3, no. 3 (2017): 103–5. https://doi.org/10.17352/2455-1759.000058.

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Antrochoanal polyps are benign mucosal lesions emerging from the maxillary sinus. The primary symptoms are nasal obstruction and rhinorrhea. Endoscopic and radiological appearance of the disease is typical. These polyps are usually presented unilaterally, although bilateral presentation is also possible. In this paper, we report a case of atypically giant antrochoanal polyp in a 13-year-old child. The patient’s primary complaint was a sensation of lump in her throat. The examination revealed a mass behind soft palate. The excised polyp had the histological characteristic of an angiomatou

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Špadijer-Mirković, Cveta, Aleksandar Perić, Biserka Vukomanović-Đurđević, and Ivan Stanojević. "CLINICAL CASE REPORT OF A LARGE ANTROCHOANAL POLYP." Acta Medica (Hradec Kralove, Czech Republic) 57, no. 2 (2014): 78–82. http://dx.doi.org/10.14712/18059694.2014.44.

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Antrochoanal polyps are benign lesions originating from the mucosa of the maxillary sinus. Nasal obstruction and rhinorrhea are their main symptoms. Their endoscopical and radiological appearance makes them relatively easy to diagnose. These polyps are usually presented unilaterally, although bilateral presentation is also possible. We described two cases of atypically giant antrochoanal polyps: in a 15-year-old child and in a 38-year-old man. In both cases, the diagnosis was done by nasal endoscopy and computed tomography (CT) of the paranasal sinuses and supported by histopathological analys

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Yayla, Muhammed, Zekai Halici, Duygu Kose, Arzu Tatar, and Mustafa SitkiGozeler. "5-HT7 receptorsare over-expressed in patients with nasal polyps." Ear, Nose & Throat Journal 96, no. 12 (2017): E14—E18. http://dx.doi.org/10.1177/0145561320919603.

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Nasal polyposis (NP) is an inflammatory disease of the paranasal sinuses and nasal cavity. The primary purpose of our study is to determine the expression of 5-HT7 receptors both in nasal polyps and in healthy tissue in the nasal cavity. The subsequent aim is to compare the expression of 5-HT7 receptors in patients with NP and in inferior turbinate tissue (control).The study included 60 participants (40 with NP and 20 controls) aged 35 to 62 years. Nasal polyp samples were collected from all patients and relative 5-HT7 receptor expression analyses were performed. RT-PCR analysis of nasal polyp

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Sharma, Manuprita, Santosh Raman, Bidhan Ray, Rupali Verma Bagga, Ramesh Kumar Sahu, and Suajoy Kumar De. "Study the relationship between nasal polyps, platelet count, mean platelet volume, neutrophil/lymphocyte ratio in patients attending otolaryngology OPD in a tertiary care teaching hospital, West Bengal." International Journal of Otorhinolaryngology and Head and Neck Surgery 3, no. 2 (2017): 228. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20170453.

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<p class="abstract"><strong>Background:</strong> Nasal obstruction is a common cause of marked nasal septal deviation. It is related strongly with hypoxia. Hypoxic conditions increase mean platelet volume levels. Many studies in literature point out that inflammation related to nasal polyp is mostly dependent on eosinophils and their inflammatory products. Beside eosinophils, platelets may have a role in nasal polyp development. Platelets are involved in hemostasis, tissue repairing and inflammation. Recently, mean platelet volume (MPV) was recognized as a simple inflammatory

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Ishibashi, Toshio, Tadashi Tanaka, Shin-Ichi Ishimoto, Ken-Ichi Nibu, and Kimitaka Kaga. "Keratinocyte Growth Factor and its Receptor Messenger RNA Expression in Nasal Mucosa and Nasal Polyps." Annals of Otology, Rhinology & Laryngology 107, no. 10 (1998): 885–90. http://dx.doi.org/10.1177/000348949810701013.

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To examine the potential biologic role of fibroblast growth factors (FGFs) in nasal polyps and nasal mucosa during chronic inflammatory conditions, we investigated messenger RNA (mRNA) expression of three members of the FGF family — Acidic FGF, basic FGF, and keratinocyte growth factor (KGF) — in nasal polyp tissues, as well as in hyperplastic nasal mucosa. Using the sensitive method reverse transcription-polymerase chain reaction (RT-PCR), we demonstrated that of the examined FGFs, KGF had the most abundant mRNA expression in nasal polyps and nasal mucosa. We also found that significantly hig

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Matveeva, N. Yu, D. G. Pavlush, and S. G. Kalinichenko. "Morphogenesis and molecular regulation of polyposis rhinosinusitis." Russian Journal of Archive of Pathology 87, no. 1 (2025): 68. https://doi.org/10.17116/patol20258701168.

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Polyposis rhinosinusitis (CRSwNP) is a heterogeneous proliferative disease characterized by inflammatory hyperplasia of the nasal mucosa with dysregulation of apoptosis and cell differentiation. The review summarizes data on the molecular cellular mechanisms of CRSwNP and presents the concept of intercellular signaling during polyposis growth. Various factors that form a specific endotype are involved in the development of a polyp. Features of morphogenesis make it possible to distinguish edematous, eosinophilic and fibrous NP. In all cases, markers of neurogenic inflammation, impaired express

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Symon, F. A., G. M. Walsh, S. R. Watson, and A. J. Wardlaw. "Eosinophil adhesion to nasal polyp endothelium is P-selectin-dependent." Journal of Experimental Medicine 180, no. 1 (1994): 371–76. http://dx.doi.org/10.1084/jem.180.1.371.

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Tissue eosinophilia is a characteristic feature of a number of inflammatory diseases including asthma and nasal polyposis. Eosinophil migration into tissues is controlled in part by interactions between eosinophil adhesion receptors and counter-structures on the vascular endothelium. To determine the receptors used by eosinophils to adhere to vascular endothelium in allergic inflammation we have adapted the Stamper-Woodruff frozen section assay (FSA) to study eosinophil adhesion to nasal polyp endothelium. Immunohistology indicated that intercellular adhesion molecule 1 (ICAM-1), E-selectin an

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Lu, Xiaoqing, He Xu, Liang Shan, Jinfeng Gao, and Jun Tong. "DMBT1 Alleviates Nasal Airway Inflammatory Response in the LPS-Induced Nasal Polyp Model." International Archives of Allergy and Immunology 184, no. 8 (2023): 808–13. http://dx.doi.org/10.1159/000529172.

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<b><i>Introduction:</i></b> The aim of this study was to investigate the effects and mechanism of deleted in malignant brain tumors 1 (DMBT1) protein on the mouse model of nasal polyps. <b><i>Methods:</i></b> The mouse model of nasal polyps was induced by intranasal drip intervention of lipopolysaccharide (LPS) 3 times a week for 12 weeks. A total of 42 mice were randomly divided into blank group, LPS group, and LPS+DMBT1 group. DMBT1 protein was applied by intranasal drip intervention in each nostril after LPS. After 12 weeks, 5 mice in each gro

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Allen, Jerilyn S., Roselle Eisma, Gerald Leonard, Denis Lafreniere, and Donald Kreutzer. "Interleukin-8 Expression in Human Nasal Polyps." Otolaryngology–Head and Neck Surgery 117, no. 5 (1997): 535–41. http://dx.doi.org/10.1016/s0194-59989770027-5.

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The cytokine Interleukin 8 (IL-8) has been shown to be a potent mediator of leukocyte recruitment and neovascularization in inflammatory and neoplastic diseases. In this study we hypothesize that IL-8 produced in the nasal polyp microenvironment is responsible for the leukocyte recruitment seen in nasal polyposis. To test this hypothesis we evaluated nasal polyps for distribution and content of IL-8 antigen with immunohistochemical techniques and radioimmunoassay to determine tissue levels of IL-8. The immunohistochemical results demonstrated that IL-8 antigen staining occurred predominantly w

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Assiri, Kholood S., Abdullah Al-shahrani, Abdullah H. Alwadai, and Mohammad S. Al Ahmari. "Relationship between postoperative recurrence rate and eosinophil density of nasal polyp: a record based retrospective study." International Journal of Otorhinolaryngology and Head and Neck Surgery 6, no. 3 (2020): 434. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20200618.

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<p class="abstract"><strong>Background:</strong> Nasal polyposis is one of the chronic sever airway diseases. It is known as a non-neoplastic inflammatory process of nasal mucosa that eventually leads to the outgrowth of abnormal masses inside the mucosa of nasal cavity and paranasal sinuses. Eosinophils and nasal polyps are believed to affect the surgical outcome of chronic rhinosinusitis (CRS). This study was conducted to determine relationship between postoperative recurrent nasal polyp rate and types of histopathology of nasal polyp.</p><p class="abstract">&lt

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Ahsan, F., H. El-Hakim, and K. W. Ah-See. "Unilateral Opacification of Paranasal Sinus CT Scans." Otolaryngology–Head and Neck Surgery 133, no. 2 (2005): 178–80. http://dx.doi.org/10.1016/j.otohns.2005.02.010.

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Objectives The aim of study was to describe the histopathology in patients with unilateral sinus opacification and to identify variables that may predict neoplastic pathology. Study Design A retrospective review of paranasal sinus CT scans performed between 2000 and 2003 was conducted to identify patients with unilateral sinus opacification. Results Twenty-eight of 1118 CT scans showed unilateral sinus opacification. Twelve patients had neoplastic disease, 13 had inflammatory disease. Nasal discharge was more common in inflammatory than neoplastic disease (P = 0.009). A polyp or mass lesion wa

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Guven, M., Y. Bulut, I. Aladag, K. Yelken, and H. Erdoğan. "Serum leptin levels in patients with nasal polyposis." Journal of Laryngology & Otology 122, no. 6 (2007): 590–92. http://dx.doi.org/10.1017/s002221510700967x.

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AbstractBackground:Nasal polyposis is one of the most common inflammatory pathologies of the nasal cavity. The aetiopathogenetic mechanisms of nasal polyp formation are still unclear.Objectives:The aim of this study was to investigate the serum leptin levels in patients with nasal polyposis.Design:A randomised, prospective study was performed of 28 adult patients with nasal polyposis and 22 control subjects of a similar age, sex and body mass index.Results:Serum leptin levels were 12.10 ± 9.39 ng/ml in the nasal polyposis patients and 6.17 ± 7.68 ng/ml in the controls. A significant difference

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Fan, Judy, William Daniels, Athenea Pascual, et al. "Blood IgE and Eosinophils are not Reliable Predictors of Nasal Tissue Eosinophils in Chronic Rhinosinusitis with Nasal Polyposis." International Archives of Otorhinolaryngology 29, no. 02 (2025): 001–5. https://doi.org/10.1055/s-0044-1801316.

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Abstract Introduction Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a chronic inflammatory condition of the paranasal sinuses that is mainly associated with type-2 inflammation. Immunoglobulin E (IgE) and eosinophils in blood and nasal tissue have been suggested as biomarkers for the prognosis and severity of CRSwNP as well as indications for biological treatment. Objective The present study aims to assess the relationships between blood IgE concentration, blood eosinophil count, and nasal polyp eosinophil count in CRSwNP patients. Methods The present study is retrospective. Nasal po

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Huang, Jingyu, and Yu Xu. "Autoimmunity: A New Focus on Nasal Polyps." International Journal of Molecular Sciences 24, no. 9 (2023): 8444. http://dx.doi.org/10.3390/ijms24098444.

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Chronic rhinosinusitis with nasal polyps (CRSwNP) has long been considered a benign, chronic inflammatory, and hyperplastic disease. Recent studies have shown that autoimmune-related mechanisms are involved in the pathology of nasal polyps. Activated plasma cells, eosinophils, basophils, innate type 2 lymphocytes, mast cells, and proinflammatory cytokine in polyp tissue indicate the mobilization of innate and adaptive immune pathways during polyp formation. The discovery of a series of autoantibodies further supports the autoimmune nature of nasal polyps. Local homeostasis dysregulation, infec

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Chiarella, Emanuela, Nicola Lombardo, Nadia Lobello, et al. "Deficit in Adipose Differentiation in Mesenchymal Stem Cells Derived from Chronic Rhinosinusitis Nasal Polyps Compared to Nasal Mucosal Tissue." International Journal of Molecular Sciences 21, no. 23 (2020): 9214. http://dx.doi.org/10.3390/ijms21239214.

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Chronic rhinosinusitis of the nasal mucosa is an inflammatory disease of paranasal sinuses, which causes rhinorrhea, nasal congestion, and hyposmia, and in some cases, it can result in the development of nasal polyposis. Nasal polyps are benign lobular-shaped growths that project in the nasal cavities; they originate from inflammation in the paranasal mucous membrane and are associated with a high expression of interleukins (IL)-4, IL-5, IL-13, and IgE. Polyps derive from the epithelial–mesenchymal transition of the nasal epithelium resulting in a nasal tissue remodeling. Nasal polyps from thr

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