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Dissertations / Theses on the topic 'Inhibition cycle'

Author: Grafiati

Published: 11 December 2022

Last updated: 19 July 2025

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1

Griffith, Jennifer Kristine. "Inhibition studies of the tubulin detyrosination/tyrosination cycle." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50033.

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Microtubules are a highly dynamic component of the cytoskeleton, which are crucial for many cellular processes. Microtubules are comprised of α/β-tubulin heterodimers, which are subject to multiple post-translational modifications including the detyrosination/tyrosination cycle. This cycle involves the removal of an RNA-encoded C-terminal α-tubulin tyrosine residue by tubulin carboxypeptidase, followed by the reattachment of the tyrosine residue by tubulin tyrosine ligase. This research project is focused on the development of an inhibitor against tubulin tyrosine ligase and tubulin carboxy

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2

ANGUS, STEVEN PATRICK. "THE MECHANISM OF RB-MEDIATED CELL CYCLE INHIBITION." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1061224578.

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3

Cot, Emilie. "Inhibition chimique des Cdk : mécanisme biochimiques et conséquences cellulaires." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20054.

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Les kinases dépendantes des Cyclines (Cdk) contrôlent le déroulement du cycle cellulaire, mais leur étude est difficile car des mécanismes de compensation se développent lorsqu'une Cdk est absente. Cdk2 est principalement impliquée dans la phase de réplication de l'ADN, cependant l'ablation génétique de Cdk2 chez la souris n'a pas d'effet sur leur développement: les fonctions de Cdk2 sont compensées par d'autres Cdk. L'inhibition chimique permet de bloquer une Cdk et de limiter les compensations. Pour étudier les rôles de Cdk2, nous l'avons inhibé avec NU6102 qui sélectif pour Cdk2 dans le mod

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4

Luo, Lingfei. "Inhibition of Hox function by the cell cycle regulator geminin." Doctoral thesis, [S.l.] : [s.n.], 2004. http://webdoc.sub.gwdg.de/diss/2004/luo/luo.pdf.

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5

Kim, Sehyun. "Nde1-mediated inhibition of ciliogenesis controls cell cycle re-entry." Oklahoma City : [s.n.], 2009.

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6

Pardali, Katerina. "Mechanisms of Regulation of the Cell Cycle Inhibitor p21Waf1/Cip1 in TGF-β-Mediated Cell Growth Inhibition". Doctoral thesis, Uppsala universitet, Ludwiginstitutet för cancerforskning, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5892.

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TGF-β is the founding member of a multifunctional family of cytokines that regulate many aspects of cell physiology, including cell growth, differentiation, motility and death and play important roles in many developmental and pathological processes. TGF-β signals by binding to a heterotetrameric complex of type I and type II serine/threonine kinase receptors. The type I receptor is phosphorylated and activated by the type II receptor and propagates the signal to the nucleus by phosphorylating and activating receptor-regulated Smad proteins (R-Smads). Once activated, the R-Smads translocate to

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7

Larrat, Sylvie. "Inhibition du cycle lytique du Virus Epstein-Barr par ARN interférence." Phd thesis, Grenoble, 2010. http://www.theses.fr/2010GRENV014.

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Le cycle lytique de l'EBV joue un rôle important dans les pathologies associées à ce virus. Participant à la fabrication de la capside virale, la protéase (PR) est essentielle à la production de virions infectieux. Elle représente ainsi une cible de choix pour une stratégie thérapeutique visant à inhiber la réplication virale. Dans ce travail, l'efficacité thérapeutique de siRNA ciblant EBV-PR a été évaluée sur des cellules épithéliales 293 transfectées avec le génome d'EBV B95-8. La diminution de l'ARNm PR a été mesurée par RT-PCR quantitative, la quantité de protéine exprimée, par Western bl

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8

Larrat, Sylvie. "Inhibition du cycle lytique du Virus Epstein-Barr par ARN interférence." Phd thesis, Grenoble, 2010. http://tel.archives-ouvertes.fr/tel-00502326.

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Le cycle lytique de l'EBV joue un rôle important dans les pathologies associées à ce virus. Participant à la fabrication de la capside virale, la protéase (PR) est essentielle à la production de virions infectieux. Elle représente ainsi une cible de choix pour une stratégie thérapeutique visant à inhiber la réplication virale. Dans ce travail, l'efficacité thérapeutique de siRNA ciblant EBV-PR a été évaluée sur des cellules épithéliales 293 transfectées avec le génome d'EBV B95-8. La diminution de l'ARNm PR a été mesurée par RT-PCR quantitative, la quantité de protéine exprimée, par Western bl

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9

Winks, Joanna Shaw. "Agonist-induced inhibition of the m-current : involvement of the phosphoinositide cycle." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405561.

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10

Onofrillo, Carmine <1984&gt. "Ribosome Biogenesis and cell cycle regulation: Effect of RNA Polymerase III inhibition." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5422/1/Carmine_Onofrillo_Tesi_Dottorato.pdf.

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In cycling cells positive stimuli like nutrient, growth factors and mitogens increase ribosome biogenesis rate and protein synthesis to ensure both growth and proliferation. In contrast, under stress situation, proliferating cells negatively modulate ribosome production to reduce protein synthesis and block cell cycle progression. The main strategy used by cycling cell to coordinate cell proliferation and ribosome biogenesis is to share regulatory elements, which participate directly in ribosome production and in cell cycle regulation. In fact, there is evidence that stimulation or inhibition

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11

Onofrillo, Carmine <1984&gt. "Ribosome Biogenesis and cell cycle regulation: Effect of RNA Polymerase III inhibition." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5422/.

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In cycling cells positive stimuli like nutrient, growth factors and mitogens increase ribosome biogenesis rate and protein synthesis to ensure both growth and proliferation. In contrast, under stress situation, proliferating cells negatively modulate ribosome production to reduce protein synthesis and block cell cycle progression. The main strategy used by cycling cell to coordinate cell proliferation and ribosome biogenesis is to share regulatory elements, which participate directly in ribosome production and in cell cycle regulation. In fact, there is evidence that stimulation or inhibition

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12

Thompson, Ruth Helen. "Inhibition of Chk1 abrogates differential cell cycle responses to cisplatin whilst enhancing cytotoxicity." Thesis, University of Sheffield, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527234.

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13

Pardali, Katerina. "Mechanisms of Regulation of the Cell Cycle Inhibitor p21^Waf1/Cip1 in TGF-β-Mediated Cell Growth Inhibition". Doctoral thesis, Uppsala University, Ludwig Institute for Cancer Research, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5892.

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<p>TGF-β is the founding member of a multifunctional family of cytokines that regulate many aspects of cell physiology, including cell growth, differentiation, motility and death and play important roles in many developmental and pathological processes. TGF-β signals by binding to a heterotetrameric complex of type I and type II serine/threonine kinase receptors. The type I receptor is phosphorylated and activated by the type II receptor and propagates the signal to the nucleus by phosphorylating and activating receptor-regulated Smad proteins (R-Smads). Once activated, the R-Smads translocate

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14

Harshman, D. K., B. M. Rao, J. E. McLain, G. S. Watts, and J. Y. Yoon. "Innovative qPCR using interfacial effects to enable low threshold cycle detection and inhibition relief." AAAS, 2015. http://hdl.handle.net/10150/621255.

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UA Open Access Publishing Fund<br>Molecular diagnostics offers quick access to information but fails to operate at a speed required for clinical decision-making. Our novel methodology, droplet-on-thermocouple silhouette real-time polymerase chain reaction (DOTS qPCR), uses interfacial effects for droplet actuation, inhibition relief, and amplification sensing. DOTS qPCR has sample-to-answer times as short as 3 min 30 s. In infective endocarditis diagnosis, DOTS qPCR demonstrates reproducibility, differentiation of antibiotic susceptibility, subpicogram limit of detection, and thermocycling spe

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15

Atkins, Benjamin David. "Inhibition of Cdc42 during mitotic exit is required for cytokinesis in Saccharomyces cerevisiae." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11257.

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Rho GTPases are highly conserved regulators of cell polarity and the actin cytoskeleton. The role of the Rho GTPase Cdc42 and its regulation during cell division is not well understood. Using biochemical and imaging approaches in budding yeast, I demonstrate that Cdc42 activation peaks during the G1/S transition and during anaphase, but drops during mitotic exit and cytokinesis. Cdc5/Polo kinase is an important upstream cell cycle regulator that suppresses Cdc42 activity. Failure to downregulate Cdc42 during mitotic exit prevents the normal localization of key cytokinesis regulators - Iqg1 and

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16

Karkare, Swagata. "Direct inhibition of Retinoblastoma phosphorylation by Nimbolide causes cell cycle arrest and suppresses Glioblastoma growth." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1380613326.

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17

Mackey, Maureen Taylor. "Inhibition of HIV infection by co-ordinated blockade of multiple steps in the virus life-cycle." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415839.

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18

Nepon-Sixt, Brook Samuel. "Cell Cycle Arrest by TGFß1 is Dependent on the Inhibition of CMG Helicase Assembly and Activation." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6336.

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Tumorigenesis is a multifaceted set of events consisting of the deregulation of several cell-autonomous and tissue microenvironmental processes that ultimately leads to the acquisition of malignant disease. Transforming growth factor beta (TGFß) and its family members are regulatory cytokines that function to ensure proper organismal development and the maintenance of homeostasis by controlling cellular differentiation, proliferation, adhesion, and survival, as well as by modulating components of the cellular microenvironment and immune system. The pleiotropic control by TGFß of these cell int

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19

Allary, Marina. "Expression de l'aminopeptidase PfA-M1 au cours du cycle érythrocytaire de plasmodium falciparum et inhibition sélective." Lille 2, 2002. http://www.theses.fr/2002LIL2MT19.

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20

Gribble, Elizabeth J. "Cell cycle inhibition as a mode of abnormal development : the role of cell cycle checkpoint proteins and cyclin-dependent kinase inhibitors in neurodevelopmental toxicant defense /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/8466.

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21

Baghdassarian, Nathalie. "Inhibition de la prolifération des cellules lymphoïdes par les glucocorticoïdes." Lyon 1, 1999. http://www.theses.fr/1999LYO1T117.

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22

Kumari, Geeta [Verfasser], and Stefan [Gutachter] Gaubatz. "Molecular Characterization of the Induction of Cell Cycle Inhibitor p21 in Response to Inhibition of the Mitotic Kinase Aurora B / Geeta Kumari. Gutachter: Stefan Gaubatz." Würzburg : Universität Würzburg, 2014. http://d-nb.info/1109750013/34.

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23

Stoner, Terri Dorene. "Indole-3-Carbinol Inhibition of Herpes Simplex Virus Replication." Kent State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=kent1228328838.

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24

Bannbers, Elin. "The Effect of Steroid Hormones in the Female Brain During Different Reproductive States." Doctoral thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-175409.

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Women are twice as likely as men to suffer from depression and anxiety disorders and have an increased risk of onset during periods associated with hormonal changes, such as the postpartum period and the menopausal transition. Furthermore, some women seem more sensitive to normal hormone fluctuations across the menstrual cycle, since approximately 3-5% suffers from premenstrual dysphoric disorder (PMDD). Why these disorders are so common in women has not been established but there is a probable involvement of the ovarian hormones. The aim of this thesis was to investigate the effect of the ova

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Osiki, Prisca Ofure. "The effect of beta-oxidation or TCA cycle inhibition on mitochondrial function and the sensitivity of high resolution respiratory detection." Master's thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/30944.

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INTRODUCTION: A dysfunction in fatty acid beta-oxidation (β-oxidation), particularly medium chain acyl-CoA dehydrogenase (MCAD) dysfunction is a major cause of mortality and its diagnosis is usually achieved by measuring specific protein activities or metabolites in blood and/or urine samples. However, these methods do not account for secondary defects that accompany primary deficiency; such as where measures of disruption in fatty acid metabolism do not account for defects in the TCA cycle and oxidative phosphorylation. These metabolic pathways are connected and dysfunction in one pathway (pr

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26

Conti, Audrey. "Etude fonctionnelle de l'Ubinucléine, partenaire cellulaire du facteur de transcription EB1 du virus d'Epstein-Barr et inhibition du cycle lytique viral." Phd thesis, Université de Grenoble, 2012. http://tel.archives-ouvertes.fr/tel-00819882.

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Découvert en 1964, le virus d'Epstein-Barr appartient à la famille des gamma-herpèsvirus. Ce virus à ADN présente une forte prévalence (90% de la population adulte est infectée). Ce fut le premier virus identifié comme associé à des cancers (lymphome de Burkitt et d'Hodgkin, carcinome gastrique et de l'oropharynx). Ce virus a pour spécificité de posséder deux cycles distincts : latent et lytique (production de particules virales). Le facteur de transcription viral EB1 (ou Zebra) est un élément clé lors de l'initiation du cycle lytique et semble une cible importante pour l'élaboration de nouvea

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Dust, Sofia [Verfasser]. "Biochemical characterization, regulation, and inhibition of human transcription kinases CDK12 and CDK13 and human cell cycle-related kinase CDK14 / Sofia Dust." Bonn : Universitäts- und Landesbibliothek Bonn, 2019. http://d-nb.info/1223538028/34.

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28

Grinfeld, Simone. "Etude du blocage en phase G du premier cycle cellulaire, induit par les rayons X dans l'oeuf de souris." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb376057177.

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29

Diallo, Alghassimou. "Identification d’une nouvelle fonction de la protéine kinase Aurora-A." Thesis, Rennes 1, 2013. http://www.theses.fr/2013REN1S111/document.

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Les protéines kinases « Aurora » sont des régulatrices clés du cycle cellulaire. Alors que l'activité de Aurora-A est requise en début de la mitose, Aurora-B et -C sont nécessaires pour la fin de mitose. Toute perturbation de leur activité peut conduire au processus de tumorisation. Plus spécifiquement, Aurora-A se comporte à la fois comme oncogène et suppresseur de tumeur. Par conséquent, la connaissance du rôle de Aurora-A durant cycle cellulaire est essentielle. Toutefois, peu d'études ont exploré, jusque là, le rôle de Aurora-A dans les phases tardives de la mitose. En fait, l'inhibition d

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Riaño, Canalias Ferran. "The effect of inhibition of nucleotide synthesis on ribosome biogenesis and the induction of p53." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/457972.

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Ribosome biogenesis is one of the most energy consuming anabolic processes in a cell, required for the generation of the translational machinery to grow and proliferate. Moreover, this process necessitates the coordination of protein and nucleotide synthesis to generate ribosomal proteins (RPs) and ribosomal RNA (rRNA). Critically, increased rates of ribosome biogenesis are a hallmark of c-Myc driven CRC required to sustain exacerbated growth and proliferation, with recent studies showing that drugs that target ribosome biogenesis are clinically efficacious. We have previously shown that upon

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Lansink, Lianne Ida Maria. "Blood-stage Plasmodium parasite control by antibody-mediated inhibition and impaired maturation in response to host inflammation in vivo." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/228523/1/Lianne%20Ida%20Maria_Lansink_Thesis.pdf.

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This thesis examined the molecular mechanisms that are at the basis of parasite-host interactions during malaria infection, specifically focussing on antibody function and interactions during inflammation. Plasmodium parasites were recently discovered to grow slower during acute infection. This project built on that evidence and identified a role for inflammation as well as detected an initial response by the parasite to inflammation.

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32

Lata, Jean-Christophe. "Interactions entre processus microbiens, cycle des nutriments et fonctionnement du couvert herbacé: cas de la nitrification dans les sols d'une savane humide de Côte d'Ivoire sous couvert à Hyparrhenia diplandra." Phd thesis, Université Pierre et Marie Curie - Paris VI, 1999. http://tel.archives-ouvertes.fr/tel-00576611.

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La nitrification dans les sols est un processus particulièrement critique dans les systèmes pauvres en nutriments comme la savane de Lamto (Afrique de l'Ouest) où l'azote est considéré comme le facteur limitant principal de la production primaire. Les faciès dominés par la Graminée Hyparrhenia diplandra sont connus pour exprimer de faibles potentiels de nitrification et ainsi éviter les pertes de nitrate. Nous avons utilisé des sites à faible/fort potentiel de nitrification comme modèles afin d'étudier si la végétation pouvait inhiber la nitrification, et les possibles conséquences en termes d

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33

Argaud, Doriane. "Inhibition de la gluconéogenèse au niveau du cycle phosphoénolpyruvate/pyruvate : étude du mécanisme d'action de deux molécules, le phénobarbital et la metformine, sur hépatocytes isolés." Grenoble 1, 1992. http://www.theses.fr/1992GRE10055.

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La gluconeogenese hepatique a un role majeur dans le maintien de l'homeostasie glucidique aussi bien pendant le jeune qu'a l'etat nourri (glucose paradox). Les processus qui regulent la gluconeogenese, a court comme a long terme, interviennent principalement sur les cycles phosphoenolpyruvate/pyruvate et fructose 6-phosphate/fructose 1,6-diphosphate. Alors qu'a court terme, le flux gluconeogenique depend principalement des substrats (qualite et quantite) arrivant au foie et de la phosphorylation des enzymes (regulation hormonale), la regulation a long terme se caracterise principalement par de

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Hwang, Yung. "The Role of S-phase Speed During an Erythroid Transcriptional Switch." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1058.

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The cell division cycles of differentiating cells are coordinated so as to generate sufficient numbers of mature cells. The cell cycle may also regulate the process of differentiation, in ways that are not well understood. We previously discovered that during erythropoiesis, the cell cycle is synchronized with a specific developmental switch, where erythroid progenitors known as colony-forming-unit-erythroid (CFU-e) transition from a self-renewal state to a state of erythroid terminal differentiation (ETD). This switch takes place during a single cell cycle S phase and is dependent on S-phase

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35

Véquaud, Éloïse. "Étude de la réponse des cellules cancéreuses mammaires au ciblage de la Survivine par ARN interférence et inhibition pharmacologique : mise en évidence d'une régulation de la recombinaison homologue par la Survivine." Nantes, 2014. https://archive.bu.univ-nantes.fr/pollux/show/show?id=592390f7-be78-4f21-9982-1e2831fde494.

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La Survivine joue un rôle sur la survie cellulaire et la régulation du cycle cellulaire. Sa fréquente surexpression dans les cancers est associée à un mauvais pronostic et à la résistance aux traitements génotoxiques, ce qui en fait une cible thérapeutique anticancéreuse intéressante. Nous avons étudié les conséquences fonctionnelles de la déplétion en Survivine par ARN interférence et par utilisation d'un inhibiteur pharmacologique de son expression, le YM155. Nous avons mis en évidence, dans des lignées du cancer du sein déplétées en Survivine l'apparition de cassures double brin de l’ADN, a

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CHIAVETTA, Roberta. "Study of the combined effects of CDK1 inhibitors and senolytic drugs for the clearance of aneuploid-senescent cells." Doctoral thesis, Università degli Studi di Palermo, 2022. http://hdl.handle.net/10447/533837.

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Despite the progresses in discovering new therapeutic drugs and treatments, cancer is still one of the main causes of death. The biggest part of available treatments, moreover, is not always effective against tumour spread and it also has negative effects on the healthy tissues of the individual. For this reason, it is extremely relevant to find new strategies to avoid side effects during the anti-cancer therapies. Aneuploidy, an aberrant number of chromosomes in the cell, is a typical condition of cancer cells caused mainly by segregation errors and chromosomal instability (CIN). CIN is a pro

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37

Jüppner, Jessica [Verfasser], Lothar [Akademischer Betreuer] Willmitzer, and Patrick [Akademischer Betreuer] Giavalisco. "Characterization of metabolomic dynamics in synchronized Chlamydomonas reinhardtii cell cultures and the impact of TOR inhibition on cell cycle, proliferation and growth / Jessica Jüppner ; Lothar Willmitzer, Patrick Giavalisco." Potsdam : Universität Potsdam, 2015. http://d-nb.info/1218399023/34.

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SUBRA, FREDERIC. "Molecules hybrides : netropsine-intercalant. etudes physico-chimiques: interaction avec des polynucleotides et avec l'adn. etudes biologiques: inhibition du cycle viral d'un derive du virus de la leucemie murine de moloney." Paris 6, 1991. http://www.theses.fr/1991PA066641.

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Dans le cadre de travaux concernant le developpement de molecules capables d'interagir directement sur le support de l'information genetique (adn ou arn), nous avons synthetise des molecules hybrides composees d'une chaine oligopeptidique du type netropsine, reliee a un chromophore intercalant oxazolopyridocarbazole (opc). Parmi les molecules synthetisees, l'une d'elles, la net-opc presente les proprietes suivantes: sur le plan physico-chimique: elle a une constante d'association extremement elevee pour l'adn double brin riche en paires de bases a-t (6. 10#8m##1); elle possede une reconnaissan

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Macé, Katherine. "Réplication du virus de l'immunodéficience humaine (HIV-1) dans les cellules promonocytaires U937 : inhibition du cycle viral par les interférons et rôle de la protéine Tat sur la différenciation cellulaire." Lyon 1, 1991. http://www.theses.fr/1991LYO1T010.

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Zhao, Song. "Part 1 Design, Synthesis and Bioactivity of a Phosphorylated Prodrug for the Inhibition of Pin1; Part 2 Conformational Specificity of Cdc25c Substrate for Cdc2 Kinase using LC-MS/MS." Diss., Virginia Tech, 2007. http://hdl.handle.net/10919/25989.

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The phosphorylation-dependent PPIase (peptidyl prolyl isomerase), Pin1 (Protein interacting with NIMA#1), has been found to regulate cell cycle through a simple conformational change, the cis-trans isomerization of phospho-Ser/Thr-Pro amide bonds. A variety of key cell cycle regulatory phosphoproteins, including Cdc25 phosphatase,Cdc27, p53 oncogene, c-Myc oncogene, Wee1 kinase, Myt1 kinase, and NIMA kinas, have been confirmed as substrates of Pin1. Pin1 was also observed to be overexpressed in a variety of cancer cell lines, and the inhibitors of Pin1 showed antiproliferative activities towar

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Wang, Xiaodong. "Design, Syntheses, and Bioactivities of Conformationally Locked Pin1 Ground State Inhibitors." Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/26625.

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Pin1 (protein interacting with NIMA 1) is a peptidyl-prolyl isomerase involved in mitosis. As a potential anti-cancer drug target, Pin1 interacts and regulates the activity of an increasing number of cell cycle enzymes by an unknown mechanism. These cell cycle enzymes include Cdc25, Cdc27, Cyclin D1, Myt1, Wee1, NIMA, Cdc2, Plk1 and c-Myc. Recent research has revealed that Pin1 is overexpressed in a variety of cancer cell lines and Pin1 inhibitors inhibit proliferation activity of several cancer cells overexpressing Pin1. The most potent Pin1 inhibitors identified so far are in the micromolar

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Zhang, Suyang. "Mechanism of APC/C activation and substrate specificity in mitosis." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275479.

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In eukaryotes, cell proliferation and cell cycle transitions are strictly controlled by the anaphase-promoting complex/cyclosome (APC/C). The APC/C is an E3 ubiquitin ligase that regulates chromatid segregation at the metaphase to anaphase transition, exit from mitosis and the establishment and maintenance of G1. The APC/C’s catalytic activity and substrate specificity are controlled by its interactions with two coactivators, Cdc20 and Cdh1. In contrast to Cdh1, APC/C activation by Cdc20 during mitosis requires hyper-phosphorylation of APC/C subunits by cyclin-dependent kinase (Cdk) and polo k

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López, Lorenzo Ximena. "Mapping the Expression of Cyclin Dependent Kinase Inhibitors in High-Risk Neuroblastoma Cell Lines : Dynamics on Cell-Fate Decisions on Proliferation/Cell Cycle Arrest." Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-278705.

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Poor prognosis for high-risk neuroblastoma patients makes it necessary to find novel treatmentstrategies. This work aims to understand the cell cycle behavior of various high-riskneuroblastoma cell lines following chemotherapy treatment. Here, we mapped the expressionof cell cycle dependent proteins, p21 and p27, in seven high-risk neuroblastoma celllines. All cell lines showed an overall impaired growth following doxorubicin treatment.However, regrowth was observed in all cell lines between day 6 to 15 by forming colonies.The expression of p21 and p27 was measured in all cell lines showing an

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Franzén, Åsa. "Regulatory Effects of TGF-β Superfamily Members on Normal and Neoplastic Thyroid Epithelial Cells". Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1624.

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<p>Thyroid growth and function is partly regulated by growth factors binding to receptors on the cell surface. In the present thesis, the transforming growth factor-β (TGF-β) superfamily members have been studied for their role in regulation of growth and differentiation of both normal and neoplastic thyroid epithelial cells.</p><p>TGF-β1 is a negative regulator of thyrocyte growth and function. However, the importance of other TGF-β superfamily members has not been fully investigated. TGF-β1, activin A, bone morphogenetic protein (BMP)-7 and their receptors were found to be expressed in porci

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VILAREM, PUIG MARIE-JOSE. "Etude des mecanismes d'activite cytotoxique et moleculaire du bd-40, une aza-ellipticine douee de pouvoir antitumoral." Paris 6, 1987. http://www.theses.fr/1987PA066219.

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Kask, Kristiina. "Hormones, Mood and Cognition." Doctoral thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9365.

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Ovarian steroid hormones are neuroactive steroids with widespread actions in the brain, and are thus able to influence mood, behavior and cognition. In this thesis the effects of progesterone withdrawal and the direct effects of the progesterone metabolite allopregnanolone are evaluated. Allopregnanolone, through binding to the GABAA receptor complex, enhances inhibitory neurotransmission, thus exerting anxiolytic, sedative and antiepileptic effects. The acoustic startle response (ASR) is a withdrawal reflex evoked by sudden or noxious auditory stimuli, and can be measured in humans as an e

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Schaeffer, Étienne. "Etude des modifications post-traductionnelles de la protéine ATF7." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ017/document.

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L’objectif de ces travaux de thèse est l’étude des modifications post-traductionnelles de la protéine ATF7. Cette protéine est phosphorylée sur les résidus thréonine (T) 51, T53 et T112 lorsque les cellules subissent un stress (UVs, choc osmotique). Cela permet à la protéine d’être active transcriptionnellement. En absence de stress une fraction de la protéine ATF7 est sumoylée et cela induit une inhibition de son activité transcriptionnelle. Le premier projet consiste à développer des outils qui permettent l’étude de la forme sumoylée de la protéine ATF7. Ces travaux ont permis l’élaboration

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Williams, Lisa Marie. "Cell cycle inhibitors in control of chronic gammaherpesvirus infection /." Connect to abstract via ProQuest. Full text not available online, 2007.

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Thesis (Ph.D. in Microbiology) -- University of Colorado Denver, 2007.<br>Typescript. Abstract available online via ProQuest Digital Dissertations. Includes bibliographical references (leaves 207-223).

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Dandeneau, Stéphane Daniel Mulaire. "Toward breaking the vicious cycle of low self-esteem with rejection-inhibiting attentional training." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103374.

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Self-esteem involves a variety of cognitive processes that help people perceive, interpret, and process social information. A central component of people's self-esteem is their sense of belonging and feelings of acceptance. It follows that people react strongly to social rejection and that being attuned to signs of real or potential social rejection can serve a self-protection function. However, being overly attuned and sensitive to social rejection can have a paradoxical effect, whereby aberrant attentional processes can contribute to the perpetuation of the vicious cycle of low self-esteem.

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Zhu, Xi-Ning. "Regulation of cyclin dependent kinase inhibitors during the vertebrate cell cycle : a dissertation /." San Antonio : UTHSC, 2007. http://proquest.umi.com/pqdweb?did=1324370261&sid=1&Fmt=2&clientId=70986&RQT=309&VName=PQD.

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