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Journal articles on the topic 'Inhibitor chemokinu'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Calkins, Casey M., Denis D. Bensard, Julie K. Heimbach, et al. "l-Arginine attenuates lipopolysaccharide-induced lung chemokine production." American Journal of Physiology-Lung Cellular and Molecular Physiology 280, no. 3 (2001): L400—L408. http://dx.doi.org/10.1152/ajplung.2001.280.3.l400.

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Chemokines stimulate the influx of leukocytes into tissues. Their production is regulated by nuclear factor-κB (NF-κB), an inducible transcription factor under the control of inhibitory factor κB-α (IκB-α). We have previously demonstrated that l-arginine (l-Arg) attenuates neutrophil accumulation and pulmonary vascular injury after administration of lipopolysaccharide (LPS). We hypothesized thatl-Arg would attenuate the production of lung chemokines by stabilizing IκB-α and preventing NF-κB DNA binding. We examined the effect of l-Arg on chemokine production, IκB-α degradation, and NF-κB DNA b

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2

Gewirtz, AM, J. Zhang, J. Ratajczak, et al. "Chemokine regulation of human megakaryocytopoiesis." Blood 86, no. 7 (1995): 2559–67. http://dx.doi.org/10.1182/blood.v86.7.2559.2559.

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Abstract We have previously shown that platelet factor 4 (PF4), a platelet-specific CXC chemokine, can directly and specifically inhibit human megakaryocyte colony formation. We therefore hypothesized that PF4 might function as a negative autocrine regulator of megakaryocytopoiesis. Herein we present additional studies characterizing the inhibitory effect of CXC chemokines on human megakaryocyte development. We first corroborated our initial studies by showing that recombinant human (rH) PF4, like the native protein, inhibited megakaryocytopoiesis. We then examined the inhibitory properties of

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Gewirtz, AM, J. Zhang, J. Ratajczak, et al. "Chemokine regulation of human megakaryocytopoiesis." Blood 86, no. 7 (1995): 2559–67. http://dx.doi.org/10.1182/blood.v86.7.2559.bloodjournal8672559.

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We have previously shown that platelet factor 4 (PF4), a platelet-specific CXC chemokine, can directly and specifically inhibit human megakaryocyte colony formation. We therefore hypothesized that PF4 might function as a negative autocrine regulator of megakaryocytopoiesis. Herein we present additional studies characterizing the inhibitory effect of CXC chemokines on human megakaryocyte development. We first corroborated our initial studies by showing that recombinant human (rH) PF4, like the native protein, inhibited megakaryocytopoiesis. We then examined the inhibitory properties of other CX

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4

Chen, Xin, Lu Yang, Ning Zhang, et al. "Shikonin, a Component of Chinese Herbal Medicine, Inhibits Chemokine Receptor Function and Suppresses Human Immunodeficiency Virus Type 1." Antimicrobial Agents and Chemotherapy 47, no. 9 (2003): 2810–16. http://dx.doi.org/10.1128/aac.47.9.2810-2816.2003.

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ABSTRACT Shikonin is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities, including inhibition of human immunodeficiency virus (HIV) type 1 (HIV-1). G protein-coupled chemokine receptors are used by HIV-1 as coreceptors to enter the host cells. In this study, we assessed the effects of shikonin on chemokine receptor function and HIV-1 replication. The results showed that, at nanomolar concentrations, shikonin inhibited monocyte chemotaxis and calcium flux in response to a variety of CC chemokin

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5

Wu, X., G. J. Dolecki, and J. B. Lefkowith. "GRO chemokines: a transduction, integration, and amplification mechanism in acute renal inflammation." American Journal of Physiology-Renal Physiology 269, no. 2 (1995): F248—F256. http://dx.doi.org/10.1152/ajprenal.1995.269.2.f248.

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We recently observed that cytokine-induced neutrophil chemoattractant (CINC), a GRO chemokine, contributes to neutrophil migration into the inflamed glomerulus in rat. Therefore, we sought to clarify how expression of the GRO chemokines, CINC and macrophage inflammatory protein-2 (MIP-2), is regulated in mesangial cells in vitro and the kidney in vivo. Mesangial cells expressed both GRO chemokine mRNAs in response to mediators of acute renal inflammation [interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and lipopolysaccharides (LPS)], but not chronic renal inflammation

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RECKLESS, Jill, and David J. GRAINGER. "Identification of oligopeptide sequences which inhibit migration induced by a wide range of chemokines." Biochemical Journal 340, no. 3 (1999): 803–11. http://dx.doi.org/10.1042/bj3400803.

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We have identified an amino acid sequence, termed peptide 3, corresponding to amino acids 51-62 of the mature human monocyte chemoattractant protein-1 (MCP-1), which inhibits human mononuclear-cell and THP-1-cell migration induced by a wide range of chemokines. For example, peptide 3 inhibited MCP-1-induced THP-1 migration in a transwell assay with an ED50 of approx. 8 μM. Peptide 3 binds directly to THP-1 cells with an association constant of approx. 10 μM, and is therefore likely to be a direct receptor antagonist for CC and CXC chemokine receptors. By performing a structure-function analysi

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7

Kim, Jung-Hoon, Hye-Sun Lim, Hyekyung Ha, Chang-Seob Seo та Hyeun-Kyoo Shin. "Inulae Flos and Its Compounds Inhibit TNF-α- and IFN-γ-Induced Chemokine Production in HaCaT Human Keratinocytes". Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/280351.

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The present study is to investigate which kinds of solvent extracts of Inulae Flos inhibit the chemokine productions in HaCaT cell and whether the inhibitory capacity of Inulae Flos is related with constitutional compounds. The 70% methanol extract showed comparatively higher inhibition of thymus and activation-regulated chemokine (TARC/CCL17) in HaCaT cells, therefore this extract was further partitioned with n-hexane, chloroform, ethyl acetate, butanol, and water. The ethyl acetate fraction inhibited TARC, macrophage-derived chemokine (MDC/CCL22), and regulated on activation of normal T-cell

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8

Chen, Jing-Yi, You-Syuan Lai, Pei-Yi Chu, Shih-Hsuan Chan, Lu-Hai Wang, and Wen-Chun Hung. "Cancer-Derived VEGF-C Increases Chemokine Production in Lymphatic Endothelial Cells to Promote CXCR2-Dependent Cancer Invasion and MDSC Recruitment." Cancers 11, no. 8 (2019): 1120. http://dx.doi.org/10.3390/cancers11081120.

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Breast cancer-derived vascular endothelial growth factor-C (VEGF-C) has been shown to enhance lymphangiogenesis in lymph nodes to accelerate cancer metastasis. However, the remodeling of lymph node microenvironments by VEGF-C remains elusive. By in vivo selection, we established a subline (named as “LC”) with strong lymphatic tropism and high VEGF-C expression from the human MDA-MB-231 breast cancer cell line. Co-culture with LC cells or treatment with LC-conditioned medium upregulated the expression of CXC chemokines in lymphatic endothelial cells (LECs), which could be inhibited by pre-incub

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9

Liu, Dongxiang, Navid Madani, Ying Li, et al. "Crystal Structure and Structural Mechanism of a Novel Anti-Human Immunodeficiency Virus and d-Amino Acid-Containing Chemokine." Journal of Virology 81, no. 20 (2007): 11489–98. http://dx.doi.org/10.1128/jvi.02845-06.

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ABSTRACT Chemokines and their receptors play important roles in normal physiological functions and the pathogeneses of a wide range of human diseases, including the entry of human immunodeficiency virus type 1 (HIV-1). However, the use of natural chemokines to probe receptor biology or to develop therapeutic drugs is limited by their lack of selectivity and the poor understanding of mechanisms in ligand-receptor recognition. We addressed these issues by combining chemical and structural biology in research into molecular recognition and inhibitor design. Specifically, the concepts of chemical

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10

Watanabe, Toshio, Kazuhide Higuchi, Masaki Hamaguchi та ін. "Monocyte chemotactic protein-1 regulates leukocyte recruitment during gastric ulcer recurrence induced by tumor necrosis factor-α". American Journal of Physiology-Gastrointestinal and Liver Physiology 287, № 4 (2004): G919—G928. http://dx.doi.org/10.1152/ajpgi.00372.2003.

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TNF-α has numerous biological activities, including the induction of chemokine expression, and is involved in many gastric injuries. C-C chemokines [monocyte chemotactic protein (MCP)-1 and macrophage inflammatory protein (MIP)-1α] and C-X-C chemokines [MIP-2 and cytokine-induced neutrophil chemoattractant (CINC)-2α] mediate chemotaxis of monocytes and neutrophils, respectively. We examined the roles of TNF-α and dynamics of chemokine expression in gastric ulceration including ulcer recurrence and indomethacin-induced injury. Rats with healed chronic gastric ulcers received intraperitoneal TNF

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Chiou, Wen-Fei, Han-Chieh Ko, and Bai-Luh Wei. "Evodia rutaecarpaand Three Major Alkaloids Abrogate Influenza A Virus (H1N1)-Induced Chemokines Production and Cell Migration." Evidence-Based Complementary and Alternative Medicine 2011 (2011): 1–10. http://dx.doi.org/10.1093/ecam/nep238.

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Evodia rutaecarpais commonly used as an anti-inflammatory herbal remedy in traditional Chinese medicine. In this study, the ethanol extract ofE. rutaecarpa(ER) and three major quinazoline alkaloids dehydroevodiamine (DeHE), evodiamine (Evo) and rutaecarpine (Rut), isolated from ER were employed to study their inhibitory effects against influenza A virus (H1N1)-induced chemokines production in A549 lung epithelial cells as well as on chemokines-evoked cell recruitment in HL-60-differentiated macrophages. The results showed that ER was a potent inhibitor of RANTES secretion by H1N1-inoculated A5

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Golding, Hana, Julio Aliberti, Lisa R. King, et al. "Inhibition of HIV-1 infection by a CCR5-binding cyclophilin from Toxoplasma gondii." Blood 102, no. 9 (2003): 3280–86. http://dx.doi.org/10.1182/blood-2003-04-1096.

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AbstractThe activation of murine dendritic cells by Toxoplasma gondii has recently been shown to depend on a parasite protein that signals through the chemokine receptor CCR5. Here we demonstrate that this molecule, cyclophilin-18 (C-18), is an inhibitor of HIV-1 cell fusion and infection with cell-free virus. T gondii C-18 efficiently blocked syncytium formation between human T cells and effector cells expressing R5 but not X4 envelopes. Neither human nor Plasmodium falciparum cyclophilins possess such inhibitory activity. Importantly, C-18 protected peripheral blood leukocytes from infection

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Kowalska, M. Anna, Mariusz Z. Ratajczak, Marcin Majka, et al. "Stromal cell–derived factor-1 and macrophage-derived chemokine: 2 chemokines that activate platelets." Blood 96, no. 1 (2000): 50–57. http://dx.doi.org/10.1182/blood.v96.1.50.

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Abstract Platelets play roles in both thrombosis and inflammation, and chemokines that are released at sites of inflammation could potentially activate platelets. Among the chemokine receptors expressed on platelets, the CXCR4 is the receptor for chemokine stromal cell-derived factor-1 (SDF-1), and the CCR4 is the receptor for macrophage-derived chemokine (MDC). Of the chemokines tested, SDF-1 and MDC were the only 2 that activated platelets. Both are weak agonists, but they enhanced response to low-dose adenosine 5′-diphosphate (ADP), epinephrine, or serotonin. When SDF-1 and MDC were added t

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Kowalska, M. Anna, Mariusz Z. Ratajczak, Marcin Majka, et al. "Stromal cell–derived factor-1 and macrophage-derived chemokine: 2 chemokines that activate platelets." Blood 96, no. 1 (2000): 50–57. http://dx.doi.org/10.1182/blood.v96.1.50.013k40_50_57.

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Platelets play roles in both thrombosis and inflammation, and chemokines that are released at sites of inflammation could potentially activate platelets. Among the chemokine receptors expressed on platelets, the CXCR4 is the receptor for chemokine stromal cell-derived factor-1 (SDF-1), and the CCR4 is the receptor for macrophage-derived chemokine (MDC). Of the chemokines tested, SDF-1 and MDC were the only 2 that activated platelets. Both are weak agonists, but they enhanced response to low-dose adenosine 5′-diphosphate (ADP), epinephrine, or serotonin. When SDF-1 and MDC were added together,

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Alejo, Alí, Carolina Sánchez, Sylvie Amu, Padraic G. Fallon, and Antonio Alcamí. "Addition of a Viral Immunomodulatory Domain to Etanercept Generates a Bifunctional Chemokine and TNF Inhibitor." Journal of Clinical Medicine 9, no. 1 (2019): 25. http://dx.doi.org/10.3390/jcm9010025.

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The inhibition of tumor necrosis factor (TNF) through the use of either antibodies or soluble receptors is a highly effective strategy for the clinical control of chronic inflammatory conditions such as rheumatoid arthritis. Different viruses have similarly exploited this concept by expressing a set of specifically tailored secreted TNF decoy receptors to block host inflammatory responses. Poxviruses have been shown to encode at least two distinct molecules, termed Cytokine response modifier D (CrmD) and CrmB, in which a TNF inhibitor is combined with a chemokine inhibitor on the same molecule

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Tremblay, Cécile L., Françoise Giguel, Christopher Kollmann, et al. "Anti-Human Immunodeficiency Virus Interactions of SCH-C (SCH 351125), a CCR5 Antagonist, with Other Antiretroviral Agents In Vitro." Antimicrobial Agents and Chemotherapy 46, no. 5 (2002): 1336–39. http://dx.doi.org/10.1128/aac.46.5.1336-1339.2002.

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ABSTRACT SCH-C (SCH 351125) is a small-molecule antagonist of the human immunodeficiency virus type 1(HIV-1) coreceptor CCR5. It has in vitro activity against R5 viruses with 50% inhibitory concentrations ranging from 1.0 to 30.9 nM. We have studied anti-HIV-1 interactions of SCH-C with other antiretroviral agents in vitro. Synergistic interactions were seen with nucleoside reverse transcriptase inhibitors (zidovudine and lamivudine), nonnucleoside reverse transcriptase inhibitors (efavirenz), and protease inhibitors (indinavir) at all inhibitory concentrations evaluated. We have also studied

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Ghobrial, Irene, Ujjal Singha, Yazan Alsayed, et al. "Molecular Mechanisms Regulating Migration and Adhesion in Response to the Chemokine SDF-1 in Multiple Myeloma (MM)." Blood 106, no. 11 (2005): 2491. http://dx.doi.org/10.1182/blood.v106.11.2491.2491.

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Abstract Malignant plasma cells home to the bone marrow (BM). However, the mechanisms by which cells are recruited into and confined to the BM are not well understood. The G-protein coupled receptor CXCR4 and its chemokine SDF-1 regulate migration in lymphocytes. In this study, we explore the molecular mechanisms involved in migration and adhesion of plasma cells in response to SDF-1. The following inhibitors were used: the Gi protein inhibitor pertussis toxin, PTX (Sigma, Aldrich, MO) 50–100ng/ml for 16 hrs; the PI3K inhibitor LY294002 (EMD Biosciences, CA) 25–50uM for 20 minutes; the mTOR in

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Huang, Ziwei, Santosh Kumar, Won-Tak Choi, et al. "A New Class of Chemokine Analogs as Useful Research Tools to Study Chemokine Receptor Function and Promising Therapeutic Agents." Blood 104, no. 11 (2004): 3839. http://dx.doi.org/10.1182/blood.v104.11.3839.3839.

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Abstract Chemokine receptors play important roles in many physiological processes and are implicated in a wide range of human diseases including acute respiratory distress syndrome, allergic asthma, psoriasis, arthritis, multiple sclerosis, cancer, atherosclerosis and most notably AIDS. To enable the applications of chemokine ligands as probes of receptor biology and pharmacology, and inhibitors of diseases mediated by chemokine receptors, a major problem with the lack of receptor selectivity of these natural chemokines must be overcome. In this study, we have developed a chemical approach com

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Ramnath, Raina Devi, Jia Sun, Sharmila Adhikari, Liang Zhi та Madhav Bhatia. "Role of PKC-δ on substance P-induced chemokine synthesis in pancreatic acinar cells". American Journal of Physiology-Cell Physiology 294, № 3 (2008): C683—C692. http://dx.doi.org/10.1152/ajpcell.00360.2007.

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Interaction of the neuropeptide substance P (SP) with its high-affinity neurokinin-1 receptor (NK1R) plays an important role in the pathophysiology of acute pancreatitis. SP is known to stimulate the production of chemokines monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1α, and MIP-2 in pancreatic acinar cells via the activation of NF-κB. However, the signaling mechanisms by which the SP-NK1R interaction induces NF-κB activation and chemokine production remain unclear. To that end, in the present study, we investigated the participation of PKC in SP-induced

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Sun, Jia, Raina Devi Ramnath, and Madhav Bhatia. "Neuropeptide substance P upregulates chemokine and chemokine receptor expression in primary mouse neutrophils." American Journal of Physiology-Cell Physiology 293, no. 2 (2007): C696—C704. http://dx.doi.org/10.1152/ajpcell.00060.2007.

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Neuropeptides play an important role in the active communication between the nervous and immune systems. Substance P (SP) is a prominent neuropeptide involved in neurogenic inflammation and has been reported to exert various proinflammatory actions on inflammatory leukocytes including neutrophils. The present study further investigated the modulatory effect of SP (1 μM) on chemokine production and chemokine receptor expression in primary mouse neutrophils. Our results showed that SP primed neutrophils for chemotactic responses not only to the CXC chemokine macrophage inflammatory protein (MIP)

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Zhang, Songen, Milladur Rahman, Su Zhang, Bengt Jeppsson, Heiko Herwald, and Henrik Thorlacius. "Streptococcal M1 Protein Triggers Farnesyltransferase-Dependent Formation of CXC Chemokines in Alveolar Macrophages and Neutrophil Infiltration of the Lungs." Infection and Immunity 80, no. 11 (2012): 3952–59. http://dx.doi.org/10.1128/iai.00696-12.

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ABSTRACTThe M1 serotype ofStreptococcus pyogenesplays an important role in streptococcal toxic shock syndrome. Simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has been shown to inhibit streptococcal M1 protein-induced acute lung damage, although downstream mechanisms remain elusive. Protein isoprenylation, such as farnesylation and geranylgeranylation, has been suggested to regulate anti-inflammatory effects exerted by statins. Here, we examined the effect of a farnesyltransferase inhibitor (FTI-277) on M1 protein-triggered lung inflammation. Male C57BL/6 mi

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Guzzo, Christina, Jamie C. Fox, Huiyi Miao, Brian F. Volkman та Paolo Lusso. "Structural Determinants for the Selective Anti-HIV-1 Activity of the All-β Alternative Conformer of XCL1". Journal of Virology 89, № 17 (2015): 9061–67. http://dx.doi.org/10.1128/jvi.01285-15.

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ABSTRACTHIV-1 replication is regulatedin vivoby a complex network of cytokines and chemokines. XCL1/lymphotactin, a unique metamorphic chemokine, was recently identified as a broad-spectrum endogenous HIV-1 inhibitor that blocks viral entry via direct interaction with the gp120 envelope glycoprotein. HIV-1 inhibition by XCL1 requires access to the alternative all-β conformation, which interacts with glycosaminoglycans (GAGs) but not with the specific XCL1 receptor, XCR1. To investigate the structural determinants of the HIV-inhibitory function of XCL1, we performed a detailed structure-functio

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Hosokawa, Yoshitaka, Ikuko Hosokawa, Kazumi Ozaki та Takashi Matsuo. "IL-27 Modulates Chemokine Production in TNF-α -Stimulated Human Oral Epithelial Cells". Cellular Physiology and Biochemistry 43, № 3 (2017): 1198–206. http://dx.doi.org/10.1159/000481760.

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Background/Aims: Interleukin-27 (IL-27) is a cytokine which belongs to the IL-12 family. However, the role of IL-27 in the pathogenesis of periodontal disease is uncertain. The aim of this study was to examine the effect of IL-27 on chemokine production in TNF-α-stimulated human oral epithelial cells (TR146). Methods: We measured chemokine production in TR146 by ELISA. We used western blot analysis to detect the phosphorylation levels of signal transduction molecules, including STAT1 and STAT3 in TR146. We used inhibitors to examine the role of STAT1 and STAT3 activation. Results: IL-27 increa

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Galdo, Francesco Del, Peter J. Wermuth, Sankar Addya, Paolo Fortina та Sergio A. Jimenez. "NFκB activation and stimulation of chemokine production in normal human macrophages by the gadolinium-based magnetic resonance contrast agent Omniscan: possible role in the pathogenesis of nephrogenic systemic fibrosis". Annals of the Rheumatic Diseases 69, № 11 (2010): 2024–33. http://dx.doi.org/10.1136/ard.2010.134858.

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ObjectiveNephrogenic systemic fibrosis (NSF) is a generalised fibrotic disorder occurring in certain individuals with renal insufficiency exposed to gadolinium-based contrast agents (GdBCA) for MRI. Histopathological examination of affected tissues shows increased numbers of activated macrophages. To elucidate the mechanisms responsible for macrophage activation, the effects of the GdBCA Omniscan on normal human macrophage global gene expression, chemokine production and nuclear factor κB (NFκB) activation was examined.MethodsNormal human monocyte-derived macrophages were incubated with Omnisc

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Aliberti, Júlio C. S., Fabiana S. Machado, Janeusa T. Souto та ін. "β-Chemokines Enhance Parasite Uptake and Promote Nitric Oxide-Dependent Microbiostatic Activity in Murine Inflammatory Macrophages Infected with Trypanosoma cruzi". Infection and Immunity 67, № 9 (1999): 4819–26. http://dx.doi.org/10.1128/iai.67.9.4819-4826.1999.

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ABSTRACT In the present study, we describe the ability of Trypanosoma cruzi trypomastigotes to stimulate the synthesis of β-chemokines by macrophages. In vivo infection with T. cruzi led to MIP-1α, RANTES, and JE/MCP1 mRNA expression by cells from peritoneal inflammatory exudate. In addition, in vitro infection with T. cruzi resulted in expression of β-chemokine MIP-1α, MIP-1β, RANTES, and JE mRNA by macrophages. The expression of the β-chemokine MIP-1α, MIP-1β, RANTES, and JE proteins by murine macrophages cultured with trypomastigote forms ofT. cruzi was confirmed by immunocytochemistry. Int

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Hosokawa, Yoshitaka, Ikuko Hosokawa, Kazumi Ozaki та Takashi Matsuo. "The Polymethoxy Flavonoid Sudachitin Inhibits Interleukin-1β-Induced Inflammatory Mediator Production in Human Periodontal Ligament Cells". BioMed Research International 2021 (28 січня 2021): 1–6. http://dx.doi.org/10.1155/2021/8826586.

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Sudachitin, which is a polymethoxylated flavonoid found in the peel of Citrus sudachi, has some biological activities. However, the effect of sudachitin on periodontal resident cells is still uncertain. The aim of this study was to examine if sudachitin could decrease the expression of inflammatory mediators such as cytokines, chemokines, or matrix metalloproteinase (MMP) in interleukin- (IL-) 1β-stimulated human periodontal ligament cells (HPDLC). Sudachitin inhibited IL-1β-induced IL-6, IL-8, CXC chemokine ligand (CXCL)10, CC chemokine ligand (CCL)2, MMP-1, and MMP-3 production in HPDLC. On

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Lemay, Serge, Tatiana V. Lebedeva та Ajay K. Singh. "Inhibition of Cytokine Gene Expression by Sodium Salicylate in a Macrophage Cell Line through an NF-κB-Independent Mechanism". Clinical Diagnostic Laboratory Immunology 6, № 4 (1999): 567–72. http://dx.doi.org/10.1128/cdli.6.4.567-572.1999.

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ABSTRACT Macrophage-derived cytokines and chemokines are involved at multiple steps of immune and inflammatory responses, and the transcriptional factor NF-κB appears to play a pivotal role in their coordinated upregulation. The anti-inflammatory agents salicylates have been proposed to act in part by inhibiting NF-κB. We have therefore studied the effects of sodium salicylate on lipopolysaccharide (LPS)-induced κB-binding activity and on cytokine and chemokine gene expression in the RAW264.7 murine macrophage cell line and compared them to those of an established NF-κB inhibitor, pyrrolidine

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Choi, Young Bong, and John Nicholas. "Autocrine and Paracrine Promotion of Cell Survival and Virus Replication by Human Herpesvirus 8 Chemokines." Journal of Virology 82, no. 13 (2008): 6501–13. http://dx.doi.org/10.1128/jvi.02396-07.

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ABSTRACT Human herpesvirus 8 (HHV-8), which is associated with the endothelial tumor Kaposi's sarcoma, encodes three CC/β-chemokines. These are expressed early during productive (lytic) infection and are believed to be involved in immune evasion, in addition to viral pathogenesis via induction of angiogenic cytokines. Here we report that two of the HHV-8 chemokines, CCR8 agonists vCCL-1 and vCCL-2, have direct effects on endothelial survival and virus replication. The v-chemokines stimulated virus replication when added to infected cultures exogenously, and CCR8 knockdown absent v-chemokine su

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Trkola, Alexandra, William A. Paxton, Simon P. Monard, et al. "Genetic Subtype-Independent Inhibition of Human Immunodeficiency Virus Type 1 Replication by CC and CXC Chemokines." Journal of Virology 72, no. 1 (1998): 396–404. http://dx.doi.org/10.1128/jvi.72.1.396-404.1998.

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ABSTRACT We have studied the breadth and potency of the inhibitory actions of the CC chemokines macrophage inhibitory protein 1α (MIP-1α), MIP-1β, and RANTES against macrophage-tropic (M-tropic) primary isolates of human immunodeficiency virus type 1 (HIV-1) and of the CXC chemokine stromal cell-derived factor 1α against T-cell-tropic (T-tropic) isolates, using mitogen-stimulated primary CD4+T cells as targets. There was considerable interisolate variation in the sensitivity of HIV-1 to chemokine inhibition, which was especially pronounced for the CC chemokines and M-tropic strains. However, t

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Coates, Matthew S., Eric W. F. W. Alton, Garth W. Rapeport, Jane C. Davies, and Kazuhiro Ito. "Pseudomonas aeruginosa induces p38MAP kinase-dependent IL-6 and CXCL8 release from bronchial epithelial cells via a Syk kinase pathway." PLOS ONE 16, no. 2 (2021): e0246050. http://dx.doi.org/10.1371/journal.pone.0246050.

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Pseudomonas aeruginosa (Pa) infection is a major cause of airway inflammation in immunocompromised and cystic fibrosis (CF) patients. Mitogen-activated protein (MAP) and tyrosine kinases are integral to inflammatory responses and are therefore potential targets for novel anti-inflammatory therapies. We have determined the involvement of specific kinases in Pa-induced inflammation. The effects of kinase inhibitors against p38MAPK, MEK 1/2, JNK 1/2, Syk or c-Src, a combination of a p38MAPK with Syk inhibitor, or a novel narrow spectrum kinase inhibitor (NSKI), were evaluated against the release

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Goldman, David, Xianyuan Song, Ryuhei Kitai, Arturo Casadevall, Meng-Liang Zhao та Sunhee C. Lee. "Cryptococcus neoformans Induces Macrophage Inflammatory Protein 1α (MIP-1α) and MIP-1β in Human Microglia: Role of Specific Antibody and Soluble Capsular Polysaccharide". Infection and Immunity 69, № 3 (2001): 1808–15. http://dx.doi.org/10.1128/iai.69.3.1808-1815.2001.

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ABSTRACT We characterized the expression of the β-chemokines macrophage inflammatory protein 1α (MIP-1α), MIP-1β, and RANTES by primary human microglia after exposure to Cryptococcus neoformans. In the absence of specific antibody, C. neoformans failed to elicit a chemokine response, while in the presence of specific antibody, microglia produced MIP-1α and MIP-1β in amounts comparable to those induced by lipopolysaccharide. RANTES was also induced but at much lower levels. In addition to MIP-1α and MIP-1β mRNA, we observed a robust induction of monocyte chemoattractant protein 1 and interleuki

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Rosengren, Sanna, Maripat Corr, Gary S. Firestein, and David L. Boyle. "The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon." Annals of the Rheumatic Diseases 71, no. 3 (2011): 440–47. http://dx.doi.org/10.1136/ard.2011.150284.

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ObjectivesThe objective of this study was to investigate the effect of the novel Janus kinase inhibitor CP-690,550 in fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA).MethodsRA FLSs were isolated from tissue obtained by arthroplasty, cultured and serum-starved 48 h prior to stimulation. Messenger RNA and protein levels were determined by quantitative PCR and ELISA or multiplex bead assay, respectively. Phosphorylation of STAT (signal transducers and activators of transcription) proteins was determined by western blot.ResultsInterleukin-6-induced phosphorylation

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Lateef, Zabeen, Margaret A. Baird, Lyn M. Wise, Andrew A. Mercer, and Stephen B. Fleming. "Orf virus-encoded chemokine-binding protein is a potent inhibitor of inflammatory monocyte recruitment in a mouse skin model." Journal of General Virology 90, no. 6 (2009): 1477–82. http://dx.doi.org/10.1099/vir.0.009589-0.

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The parapoxvirus orf virus causes pustular dermatitis in sheep and is transmissible to humans. The virus encodes a secreted chemokine-binding protein (CBP). We examined the ability of this protein to inhibit migration of murine monocytes in response to CC inflammatory chemokines, using chemotaxis assays, and its effects on monocyte recruitment into the skin, using a mouse model in which inflammation was induced with bacterial lipopolysaccharide. CBP was shown to bind murine chemokines CCL2, CCL3 and CCL5 with high affinity by surface plasmon resonance and it completely inhibited chemokine-indu

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Talbott, Heather, Abigail Delaney, Pan Zhang, et al. "Effects of IL8 and immune cells on the regulation of luteal progesterone secretion." REPRODUCTION 148, no. 1 (2014): 21–31. http://dx.doi.org/10.1530/rep-13-0602.

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Recent studies have suggested that chemokines may mediate the luteolytic action of prostaglandin F2α (PGF). Our objective was to identify chemokines induced by PGFin vivoand to determine the effects of interleukin 8 (IL8) on specific luteal cell typesin vitro. Mid-cycle cows were injected with saline or PGF, ovaries were removed after 0.5–4 h, and expression of chemokine was analyzed by qPCR.In vitroexpression of IL8 was analyzed after PGF administration and with cell signaling inhibitors to determine the mechanism of PGF-induced chemokine expression. Purified neutrophils were analyzed for mig

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Feng, L., Y. Xia, J. I. Kreisberg, and C. B. Wilson. "Interleukin-1 alpha stimulates KC synthesis in rat mesangial cells: glucocorticoids inhibit KC induction by IL-1." American Journal of Physiology-Renal Physiology 266, no. 5 (1994): F713—F722. http://dx.doi.org/10.1152/ajprenal.1994.266.5.f713.

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To assess the possible role of the production of chemokines by intrinsic glomerular cells in the generation of inflammation in glomerulonephritis, the chemokine, KC, was cloned from a rat macrophage cDNA library. Transfection of rat KC into COS-7 cells resulted in increased neutrophil chemotactic activity. The KC cDNA was expressed as a fusion protein in Escherichia coli for generation of an antibody. By using a riboprobe derived from the cDNA and the antibody, interleukin-1 (IL-1) was found to induce the expression of KC in rat mesangial cells. The induction of KC by IL-1 could be inhibited b

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Greco, Giampaolo, Carl Mackewicz та Jay A. Levy. "Sensitivity of human immunodeficiency virus infection to various α, β and γ chemokines". Journal of General Virology 80, № 9 (1999): 2369–73. http://dx.doi.org/10.1099/0022-1317-80-9-2369.

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Examination of a large panel of chemokines indicates that in addition to RANTES, MIP-1α and MIP-1β, the β-chemokine MCP-2 and, to a lesser extent, the γ-chemokine lymphotactin also show anti-human immunodeficiency virus (HIV) activity in cell culture. The amount of chemokine needed to suppress HIV replication by ≤50% was generally greater (≤250 ng/ml) than that required for inhibition of virus infection by RANTES, MIP-1α and MIP-1β. The β-chemokine MCP-3 was found to enhance the replication of both non-syncytium-inducing (NSI) and syncytium-inducing (SI) viruses at high concentrations (0·5–5 μ

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Crilly, Anne, Susan E. Robertson, James H. Reilly, et al. "Phosphodiesterase 4 (PDE4) regulation of proinflammatory cytokine and chemokine release from rheumatoid synovial membrane." Annals of the Rheumatic Diseases 70, no. 6 (2011): 1130–37. http://dx.doi.org/10.1136/ard.2010.134825.

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BackgroundThe cAMP-metabolising enzyme, phosphodiesterase 4 (PDE4), has been implicated in a number of immune responses, including tumour necrosis factor α (TNFα) production. To date, few data have directly addressed whether synovial cytokine and chemokine production is modified by PDE4.ObjectiveUsing specific PDE4 inhibitors, roflumilast plus two novel inhibitors, INH 0061 and INH 0062, the authors studied the effect of PDE4 inhibition on proinflammatory cytokine and chemokine release from primary rheumatoid arthritis (RA) synovial digest suspensions and in a macrophage T cell co-culture assa

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Burger, Jan A., Meike Burger, and Thomas J. Kipps. "Chronic Lymphocytic Leukemia B Cells Express Functional CXCR4 Chemokine Receptors That Mediate Spontaneous Migration Beneath Bone Marrow Stromal Cells." Blood 94, no. 11 (1999): 3658–67. http://dx.doi.org/10.1182/blood.v94.11.3658.

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Abstract Chemokines play a central role for lymphocyte trafficking and homing. The mechanisms that direct the tissue localization of B cells from patients with chronic lymphocytic leukemia (B-CLL) are unknown. We found that CLL B cells express functional CXCR4 receptors for the chemokine stromal cell-derived factor-1 (SDF-1), as demonstrated by receptor endocytosis, calcium mobilization, and actin polymerization assays. Moreover, CLL B cells displayed chemotaxis to this chemokine that could be inhibited by monoclonal antibodies (MoAbs) against CXCR4, pertussis toxin, or Wortmannin, a phosphati

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Burger, Jan A., Meike Burger, and Thomas J. Kipps. "Chronic Lymphocytic Leukemia B Cells Express Functional CXCR4 Chemokine Receptors That Mediate Spontaneous Migration Beneath Bone Marrow Stromal Cells." Blood 94, no. 11 (1999): 3658–67. http://dx.doi.org/10.1182/blood.v94.11.3658.423k11_3658_3667.

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Chemokines play a central role for lymphocyte trafficking and homing. The mechanisms that direct the tissue localization of B cells from patients with chronic lymphocytic leukemia (B-CLL) are unknown. We found that CLL B cells express functional CXCR4 receptors for the chemokine stromal cell-derived factor-1 (SDF-1), as demonstrated by receptor endocytosis, calcium mobilization, and actin polymerization assays. Moreover, CLL B cells displayed chemotaxis to this chemokine that could be inhibited by monoclonal antibodies (MoAbs) against CXCR4, pertussis toxin, or Wortmannin, a phosphatidylinosit

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Rajajendram, Revathee, Chau Ling Tham, Mohamad Nadeem Akhtar, Mohd Roslan Sulaiman та Daud Ahmad Israf. "Inhibition of Epithelial CC-Family Chemokine Synthesis by the Synthetic Chalcone DMPF-1 via Disruption of NF-κB Nuclear Translocation and Suppression of Experimental Asthma in Mice". Mediators of Inflammation 2015 (2015): 1–15. http://dx.doi.org/10.1155/2015/176926.

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Asthma is associated with increased pulmonary inflammation and airway hyperresponsiveness. The interaction between airway epithelium and inflammatory mediators plays a key role in the pathogenesis of asthma.In vitrostudies evaluated the inhibitory effects of 3-(2,5-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one (DMPF-1), a synthetic chalcone analogue, upon inflammation in the A549 lung epithelial cell line. DMPF-1 selectively inhibited TNF-α-stimulated CC chemokine secretion (RANTES, eotaxin-1, and MCP-1) without any effect upon CXC chemokine (GRO-αand IL-8) secretion. Western blot ana

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Ngo, Hai, Evdoxia Hatjiharissi, Xavier Leleu, et al. "The CXCR4/SDF-1 Axis Regulates Migration and Adhesion in Waldenstrom Macroglobulinemia." Blood 108, no. 11 (2006): 2418. http://dx.doi.org/10.1182/blood.v108.11.2418.2418.

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Abstract Background: Waldenstrom Macroglobulinemia (WM) is characterized by widespread involvement of the bone marrow (BM), and lymphadenopathy in 20% of the patients, implying continuous trafficking of WM cells into and out of the BM and lymph nodes. The normal process of B-cell homing is regulated by cytokines, chemokines, and adhesion molecules. One of the most extensively studied chemokines in migration is stromal derived factor SDF-1 and its receptor CXCR4. Here we study the role of chemokine receptors, and the SDF-1/CXCR4 axis on migration and adhesion in WM. Methods: Flow cytometry for

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Salinthone, Sonemany, Cherie A. Singer, and William T. Gerthoffer. "Inflammatory gene expression by human colonic smooth muscle cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 287, no. 3 (2004): G627—G637. http://dx.doi.org/10.1152/ajpgi.00462.2003.

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Intestinal mucosal cells and invading leukocytes produce inappropriate levels of cytokines and chemokines in human colitis. However, smooth muscle cells of the airway and vasculature also synthesize cytokines and chemokines. To determine whether human colonic myocytes can synthesize proinflammatory mediators, strips of circular smooth muscle and smooth muscle cells were isolated from human colon. Myocytes and muscle strips were stimulated with 10 ng/ml of IL-1β, TNF-α, and IFN-γ, respectively. Expression of mRNA for IL-1β, IL-6, IL-8, and cyclooxygenase-2 (COX-2) was induced within 2 h and con

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Vargaftig, B. Boris, and Monique Singer. "Leukotrienes, IL-13, and chemokines cooperate to induce BHR and mucus in allergic mouse lungs." American Journal of Physiology-Lung Cellular and Molecular Physiology 284, no. 2 (2003): L260—L269. http://dx.doi.org/10.1152/ajplung.00226.2002.

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In mice, intratracheal challenges with antigen (ovalbumin) or recombinant murine interleukin-13 (IL-13) induce lung inflammation, bronchial hyperreactivity (BHR), and mucus accumulation as independent events (Singer M, Lefort J, and Vargaftig BB. Am J Respir Cell Mol Biol 26: 74–84, 2002), largely mediated by leukotrienes (LT). We previously showed that LTC4 was released 15 min after ovalbumin, and we show that it induces the expression of monocyte chemoattractant proteins 1 and 5 and KC in the lungs, as well as IL-13 mRNA. Instilled intratracheally, these chemokines induced BHR and mucus accu

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Iwakura, Takamasa, Zhibo Zhao, Julian A. Marschner, Satish Kumar Devarapu, Hideo Yasuda, and Hans Joachim Anders. "Dipeptidyl peptidase-4 inhibitor teneligliptin accelerates recovery from cisplatin-induced acute kidney injury by attenuating inflammation and promoting tubular regeneration." Nephrology Dialysis Transplantation 34, no. 10 (2019): 1669–80. http://dx.doi.org/10.1093/ndt/gfy397.

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AbstractBackgroundCisplatin is an effective chemotherapeutic agent. However, acute kidney injury (AKI) and subsequent kidney function decline limits its use. Dipeptidyl peptidase-4 (DPP-4) inhibitor has been reported to attenuate kidney injury in some in vivo models, but the mechanisms-of-action in tubule recovery upon AKI remain speculative. We hypothesized that DPP-4 inhibitor teneligliptin (TG) can facilitate kidney recovery after cisplatin-induced AKI.MethodsIn in vivo experiment, AKI was induced in rats by injecting 5 mg/kg of cisplatin intravenously. Oral administration of 10 mg/kg of TG

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Schols, Dominique, Sofie Struyf, Jo Van Damme, José A. Esté, Geoffrey Henson, and Erik De Clercq. "Inhibition of T-tropic HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4." Journal of Experimental Medicine 186, no. 8 (1997): 1383–88. http://dx.doi.org/10.1084/jem.186.8.1383.

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Bicyclams are a novel class of antiviral compounds that are highly potent and selective inhibitors of the replication of HIV-1 and HIV-2. Surprisingly, however, when the prototype compound AMD3100 was tested against M-tropic virus strains such as BaL, ADA, JR-CSF, and SF-162 in human peripheral blood mononuclear cells, the compound was completely inactive. Because of the specific and potent inhibitory effect of AMD3100 on T-tropic viruses, but not M-tropic viruses, it was verified that AMD3100 interacts with the CXC-chemokine receptor CXCR4, the main coreceptor used by T-tropic viruses. AMD310

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Jamaluddin, Mohammad, Sanjeev Choudhary, Shaofei Wang та ін. "Respiratory Syncytial Virus-Inducible BCL-3 Expression Antagonizes the STAT/IRF and NF-κB Signaling Pathways by Inducing Histone Deacetylase 1 Recruitment to the Interleukin-8 Promoter". Journal of Virology 79, № 24 (2005): 15302–13. http://dx.doi.org/10.1128/jvi.79.24.15302-15313.2005.

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ABSTRACT Respiratory syncytial virus (RSV) is a paramyxovirus that produces airway inflammation, in part by inducing interleukin-8 (IL-8) expression, a CXC-type chemokine, via the NF-κB/RelA and STAT/IRF signaling pathways. In RSV-infected A549 cells, IL-8 transcription attenuates after 24 h in spite of ongoing viral replication and persistence of nuclear RelA, suggesting a mechanism for transcriptional attenuation. RSV infection induces B-cell lymphoma protein -3 (Bcl-3) expression 6 to 12 h after viral infection, at times when IL-8 transcription is inhibited. By contrast, 293 cells, deficien

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O'Hayre, Morgan, Catherina L. Salanga, Tracy M. Handel, and Samantha J. Allen. "Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment." Biochemical Journal 409, no. 3 (2008): 635–49. http://dx.doi.org/10.1042/bj20071493.

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Inappropriate chemokine/receptor expression or regulation is linked to many diseases, especially those characterized by an excessive cellular infiltrate, such as rheumatoid arthritis and other inflammatory disorders. There is now overwhelming evidence that chemokines are also involved in the progression of cancer, where they function in several capacities. First, specific chemokine–receptor pairs are involved in tumour metastasis. This is not surprising, in view of their role as chemoattractants in cell migration. Secondly, chemokines help to shape the tumour microenvironment, often in favour

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Braunersreuther, Vincent, Graziano Pelli, Katia Galan, et al. "Treatment with the CC chemokine-binding protein Evasin-4 improves post-infarction myocardial injury and survival in mice." Thrombosis and Haemostasis 110, no. 10 (2013): 807–25. http://dx.doi.org/10.1160/th13-04-0297.

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summaryChemokines trigger leukocyte trafficking and are implicated in cardiovascular disease pathophysiology. Chemokine-binding proteins, called “Evasins” have been shown to inhibit both CC and CXC chemokinemediated bioactivities. Here, we investigated whether treatment with Evasin-3 (CXC chemokine inhibitor) and Evasin-4 (CC chemokine inhibitor) could influence post-infarction myocardial injury and remodelling. C57Bl/6 mice were submitted in vivo to left coronary artery permanent ligature and followed up for different times (up to 21 days). After coronary occlusion, three intraperitoneal inje

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Villalta, Fernando, Yuan Zhang, Kartz E. Bibb, John C. Kappes та Maria F. Lima. "The Cysteine-Cysteine Family of Chemokines RANTES, MIP-1α, and MIP-1β Induce Trypanocidal Activity in Human Macrophages via Nitric Oxide". Infection and Immunity 66, № 10 (1998): 4690–95. http://dx.doi.org/10.1128/iai.66.10.4690-4695.1998.

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ABSTRACT This paper describes a new role for the cysteine-cysteine (CC) chemokines RANTES, MIP-1α, and MIP-1β on human macrophage function, which is the induction of nitric oxide (NO)-mediated trypanocidal activity. In a previous report, we showed that RANTES, MIP-1α and MIP-1β enhance Trypanosoma cruzi uptake and promote parasite killing by human macrophages (M. F. Lima, Y. Zhang, and F. Villalta, Cell. Mol. Biol. 43:1067–1076, 1997). Here we study the mechanism by which RANTES, MIP-1α, and MIP-1β activate human macrophages obtained from healthy individuals to kill T. cruzi. Treatment of huma

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Ottersbach, Katrin, John Mclean, Neil W. Isaacs, and Gerard J. Graham. "A310 helical turn is essential for the proliferation-inhibiting properties of macrophage inflammatory protein-1 alpha (CCL3)." Blood 107, no. 4 (2006): 1284–91. http://dx.doi.org/10.1182/blood-2005-08-3112.

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Despite possessing marked structural similarities, the chemokines macrophage inflammatory protein-1α (MIP-1α; CCL3) and RANTES (CCL5) display differential activity in hematopoietic progenitor-cell-inhibitory assays, with MIP-1α being active and RANTES inactive in this context. We have sought to identify the key structural determinants of this property of MIP-1α. This has involved constructing MIP-1α/RANTES chimeras by swapping structural domains between the 2 proteins. Results indicate that, in contrast to other chemokine functions, neither the N nor the C termini are key determinants of inhib

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