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Dissertations / Theses on the topic 'Inhibitory and tolerant effect'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Miller, Melissa A. "Examining the Vulnerability of Inhibitory Control to the Impairing Effects of Alcohol." UKnowledge, 2014. http://uknowledge.uky.edu/psychology_etds/46.

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There is growing evidence that acute changes in fundamental mechanisms of impulse control contribute to the transition from social drinking to abusive drinking. One component of impulsivity concerns the ability to inhibit maladaptive behaviors (i.e., inhibitory control). Inhibitory mechanisms are reliably shown to be sensitive to the impairing effects of alcohol, and studies have begun to show that this impairment fails to recover at the same speed as other aspects of behavior. However, the degree to which inhibitory control develops tolerance to alcohol has only been examined under limited co

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2

Russell, Matthew. "DIAPHRAGMATIC BREATHING AND ITS EFFECT ON INHIBITORY CONTROL." UKnowledge, 2014. http://uknowledge.uky.edu/psychology_etds/53.

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Evidence suggests that slow paced diaphragmatic breathing (DB) can significantly affect prefrontal cortex functions through increasing an individual’s physiological self-regulatory capacity. The current research demonstrates the effects of paced DB on inhibitory control, which is considered to be a reliable measure of behavioral self-regulation. Eighty healthy participants were randomly assigned to one of two conditions (20 males and females each). Participants were instructed on either DB at a pace of six-breaths per minute (BPM) or instructions on environmental awareness and asked to breathe

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3

Okolo, Bartholomew Ndubuisi. "Alcohol tolerance in yeast : on factors influencing the inhibitory and toxic effects of alcohols on distilling yeast." Thesis, University of Strathclyde, 1986. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=24267.

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An investigation of the factors influencing the inhibitory and toxic effects of ethanol and higher alcohols, byproducts of alcoholic fermentation, on yeast, is presented. The relative potency of alcohols was found to correlate strongly with the carbon chain-length or molecular size and the lipid solubility of the respective alcohols. Higher alcohols act synergistically with each other and with ethanol in causing cell death of suspensions of non-growing Saccharomyces cerevisiae. The presence of higher alcohols in fermented broth, even at low concentrations, and other by-products of alcoholic fe

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4

Correia, Giovanna Riello Barbosa. "Inhibitory effect in vitro of farnesol against Burkholderia pseudomallei biofilms." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16814.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>A intrÃnseca resistÃncia apresentada pela bactÃria Burkholderia pseudomallei Ã um grave empecilho para o tratamento da melioidose. Muitas pesquisas focam na busca de adjuvantes que aumentem a sensibilidade desta bactÃria aos antimicrobianos. Nesse contexto, a aÃÃo inibitÃria do farnesol frente Ãs cepas de B. pseudomallei, na forma planctÃnica, jÃ foi relatada em estudo prÃvio. Diante disso, esse estudo objetivou analisar a atividade in vitro do farnesol contra cepas de B. pseudomallei na forma de biofilme. Aliado Ã anÃlise da aÃÃo

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5

Sirakata, Yoshiharu. "Inhibitory effect of plasma FKBP12 on immunosuppressive activity of FK506." Kyoto University, 1997. http://hdl.handle.net/2433/202225.

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6

OKUMURA, NOBUYOSHI, TAKAHARU KONDO, AIJI NODA та TETUO HAYAKAWA. "Effects of Acarbose, an α-Glucosidase Inhibitor (BAY G 5421), on Orally Loaded Glucose, Maltose and Sucrose and on Blood Glucose Control in Non-Insulin-Dependent Diabetics". Nagoya University School of Medicine, 1985. http://hdl.handle.net/2237/17475.

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7

Mishra, Priyambada. "Study of Inhibitory Effect of Epididymal Cres on Pc4/Pcsk4 Activity." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19954.

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PC4/PCSK4 is the major Proprotein Convertase (PC) enzyme that plays a key role in mammalian fertilisation. It is detected in the acrosomal granules of round spermatids, acrosomal ridges of elongated spermatids and sperm plasma membrane overlying the acrosome with K-X-K/X-R as its preferred cleavage motif. Such motifs are present in male germ cell proteins ADAMs, proPACAP and proIGF-1/2 and these precursor proteins are processed most likely by PC4 during spermatogenesis, sperm maturation and sperm-egg interaction. For fertilization to occur, the mature sperm must penetrate the Zona Pelucida (ZP

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8

林浩強 and Ho-keung Lam. "Inhibitory effect of tetramethylpyrazine (TMP) on nitric oxide production in macrophages." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31970163.

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9

Lam, Ho-keung. "Inhibitory effect of tetramethylpyrazine (TMP) on nitric oxide production in macrophages." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23295041.

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10

Yuh, Seon Hee. "Cloning genes differentially expressed in freezing tolerant orchids." Virtual Press, 1996. http://liblink.bsu.edu/uhtbin/catkey/1020165.

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Genes responsible for differences in gene regulation and expression in normal cells and freezing tolerant cells were identified using two related wintergreen orchid species, Aplectrum hyemale and Tipularia discolor. Changes in gene expression observed in field-collected tissues obtained from different seasons were compared as were changes observed in plants subjected to cold shock in a laboratory environmental chamber. In order to clone these differentially expressed genes which may confer photosynthesis cold tolerance, the recently developed technique, mRNA differential display was employed.

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11

DU, BOYANG. "Fault Tolerant Electronic System Design." Doctoral thesis, Politecnico di Torino, 2016. http://hdl.handle.net/11583/2644047.

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Due to technology scaling, which means reduced transistor size, higher density, lower voltage and more aggressive clock frequency, VLSI devices may become more sensitive against soft errors. Especially for those devices used in safety- and mission-critical applications, dependability and reliability are becoming increasingly important constraints during the development of system on/around them. Other phenomena (e.g., aging and wear-out effects) also have negative impacts on reliability of modern circuits. Recent researches show that even at sea level, radiation particles can still induce soft

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12

Westmoreland, Martin. "Development of a fault tolerant MOS field effect power semiconductor switching transistor." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/55310/.

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This work describes the development of a semiconductor switch to replace an electromechanical contactor as used within the electrical power distribution system of the More Electric Aircraft (MEA; a project begun in the 1990‟s by the United States Air Force). The MEA is safety critical and therefore requires highest reliability components and systems, but subsequent to a short circuit load fault the electro-mechanical contactor switch often welds shut. This risk is increased when using high discharge energy lithium ion dc batteries. Predominately the semiconductor switch controls inductive load

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13

Dalidjan, Mulyani. "Caries inhibitory effect of fluoride co-crystallized sucrose : establishing a field trial /." Title page, contents and summary only, 1995. http://web4.library.adelaide.edu.au/theses/09PH/09phd143.pdf.

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14

Oberholzer, Ian Dewald. "Evaluation of the enzyme inhibitory effect of carboxymethylated chitosan / Ian Dewald Oberholzer." Thesis, North-West University, 2003. http://hdl.handle.net/10394/245.

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Degradation of peroral administered drugs by various enzymes in the gastrointestinal tract has proven to be troublesome for the absorption' and bioavailability of protein and peptide drugs. Mucoadhesive polymers such as poly(acrylates) have proven to inhibit protease enzymes responsible for initiating digestion of peptide drugs. Enzyme inhibitors have unique chemical properties enabling it to interact with enzymes to form complexes with such enzymes prohibiting it from functioning properly. Anionic carboxymethylated chitosan derivatives such as N,N-dicarboxymethyl chitosan and N, O-carboxymeth

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15

Gurney, Angela. "The effect of challenging inhibitory tasks on subsequent susceptibility to unconscious influences." Thesis, University of Sussex, 2018. http://sro.sussex.ac.uk/id/eprint/76490/.

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Previous research has examined a variety of behavioural effects, thought to stem from mental exhaustion, following the prior use of inhibitory control. Here we attempt to examine whether such effects are apparent in unconscious behaviours. Chapter 1 demonstrates no effect of prior use of inhibitory control on subsequent susceptibility to subliminal priming of neutral (Experiment 1) and reward (Experiment 2) terms. Chapter 2 explores whether the prior use of inhibitory control influences the degree of susceptibility to an alternative source of influence, hypnotic induction, and provides the nov

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16

Saunders, Jo. "Inhibitory processes in the misinformation effect : negative consequences of an adaptive process." Thesis, University of St Andrews, 2004. http://hdl.handle.net/10023/13122.

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Recent research has suggested the seemingly ironic possibility that in order to be able to remember effectively, we must be able to forget. Despite the fact that forgetting is typically conceived of as a wholly negative experience it may, nonetheless, have adaptive consequences for the efficient updating of memory. Without a method for setting aside out-of-date or unwanted information, we may be unable to satisfy current memorial goals. Recent research suggests that inhibitory processes operating during retrieval may be responsible for the temporary forgetting of unwanted information so that d

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17

Morita, Tateo 1958. "Effect of inbreeding on germination salt tolerance in alfalfa." Thesis, The University of Arizona, 1987. http://hdl.handle.net/10150/276644.

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The performance of an alfalfa (Medicago sativa L.) population has been improved by recurrent selection for germination salt tolerance. However, recurrent selection may lead to increased inbreeding. Since alfalfa is subject to severe inbreeding depression, accumulation of inbreeding during the selection process may negatively affect performance. This experiment was designed to determine the effects of inbreeding on germination performance in alfalfa under saline and non-saline conditions. The germination performance of seed having three different levels of inbreeding as examined. No adverse eff

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18

Ferenz, Hans-Jörg, and Martin G. Peter. "The inhibitory effect of sinefungin on juvenile hormone biosynthesis and development in locusts." Universität Potsdam, 1987. http://opus.kobv.de/ubp/volltexte/2008/1681/.

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The antibiotic fungal metabolite sinefungin is a potent inhibitor of S-adenosylmethionine-acceptor methyltransferases. Its effect on insect metabolism and especially on corpora allata farnesoic acid methyltransferase, which catalyzes the penultimate step of juvenile hormone biosynthesis, was investigated in Locusta migratoria. Injection of sinefungin results in a delay of imaginal molt and in suppression of ovary development. Isolated corpora allata are unable to synthesize juvenile hormone III in the presence of more than 1.0 mM sinefungin. In a cell-free system containing the S-adenosylmethi

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19

Virgo, Gordon. "Traditional Scandinavian Beer Brewing: Microbial Inhibitory effect of Myrica gale and Rhodondendron tomentosum." Thesis, Uppsala universitet, Systematisk biologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-141807.

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20

Hidir, Saadiah M. "The inhibitory effect of cyclic 3',5' adenosine monophosphate and putrescine in inflammation." Thesis, Aston University, 1985. http://publications.aston.ac.uk/12501/.

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21

Abu-Elteen, Khalid Hussein. "Effect of sub-inhibitory concentrations of antifungal drugs on adherence of Candida species." Thesis, Loughborough University, 1991. https://dspace.lboro.ac.uk/2134/33210.

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The adherence of three Candida species to human buccal epithelial cells (BECs) following treatment of the yeast with sub-inhibitory concentrations of amphotericin B, nystatin, miconazole nitrate, 5-fluorocytosine, octenidine and pirtenidine was investigated in vitro. Pre-incubation of C. albicans (two strains), C. tropicalis or C.kefyr with these antifungal drugs inhibited their adherence to varying degrees (reduction between 17% and 78% of the control value). Pre-treatment of yeast for a short period (l hr) had less effect on adhesion than pre-treatment for a long period (24 hr). Furthermore,

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22

Kodawara, Takaaki. "Inhibitory effect of ciprofloxacin on β-glucuronidase-mediated deconjugation of mycophenolic acid glucuronide". Kyoto University, 2015. http://hdl.handle.net/2433/198935.

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23

Pan, Hui-Ru, and 潘慧如. "Study on inhibitory mechanism on acetylcholinesterase by comparing inhibitory effect of territrem B modified compounds." Thesis, 1992. http://ndltd.ncl.edu.tw/handle/63487848936207063127.

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24

Wang, Sheng-Horng, and 王勝弘. "Inhibitory Effect of Phenylacetylamino Acids on Methionine Adenosyltransferase." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/67033437412702169109.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>87<br>A series of Phenylacetylamino acids were tested for the inhibition of methionine adenosyltransferase (MAT) activity. The results demonstrate that some of these tested compounds exhibited significant inhibitory activities. Among them, compounds 4, 10, 11, 12, 15, 21, 22, 25, 26, 27 showed more potent activity than phenylacetic acid. HPLC was also employed in this study trying to establish a different mode of investigation other than traditional isotopic evaluation. Differences between HPLC and the isotopic method were compared with this comparison, effective ass

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25

Chyi, Yang Horng, and 楊鴻旗. "The Inhibitory Effect of Butenin in Cancer Metastasis." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/43242761799248092751.

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碩士<br>慈濟大學<br>藥理暨毒理學碩士班/博士班<br>102<br>3,4,2’,4’-Tetrahydroxychalcone (butein) is a type of chalcone derivatives which is a group of flavonoid. Flavonoid is one such agent of polyphenol from the numerous plants tissues including stem-bark of cashews (Semecarpus anacardium), the heartwood of Dalbergia odorifera and including Caragana jubata and Rhus verniciflua stokes in traditional Chinese and Tibetan medicinal herbs. The extract of native butein predominantly contains the potent chalcone with the reported benefits include antioxidant activity, anti-inflammatory activity, elicitation of endothe

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26

Huang, Shu-jung, and 黃姝榕. "Inhibitory effect of gallic acid on HSC proliferation." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/54167982501008315831.

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碩士<br>國立暨南國際大學<br>生物醫學科技研究所<br>95<br>Modern medical technology improves health and wellness of human beings. Certain diseases, however, still require more attentions and studies. Liver diseases, including acute and chronic, are most common diseases in Taiwan. Many efforts have been made to treat these diseases. Among the chronic liver diseases, liver fibrosis is a critical point of the disease progress. The formation of fibrosis is the result of imbalanced synthesis and degradation of extra cellular matrix proteins, for example, collagen. Excessive accumulation and abnormal distribution of col

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27

Chen, Yun-Yu, and 陳韻伃. "The inhibitory effect of phytochemicals on adipocyte differentiation." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/qam3z7.

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博士<br>國立陽明大學<br>生化暨分子生物研究所<br>100<br>The incidence of obesity dramatically rising worldwide and is a major contributor to the global burden of metabolic disorders. Excessive accumulation of adipose tissue mass contributes to the development of obesity. Adipogenesis, combines with adipocyte differentiation and proliferation, is an important mechanism that leading to the increase of adipocytes. Therefore, inhibition of adipogenesis is the key way to prevent obesity. Several studies have been discussed the therapeutic potentials of essential oil and their volatile components, including anti-obesi

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28

Lin, Yu-Hsuan, and 林育萱. "Growth Inhibitory Effect on Bacteria of Natural Products." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/ww2ft4.

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29

Chang, Heng-Jia, and 張恆嘉. "Growth Inhibitory Effect of ZC008 Active Extracts on ActivatedGrowth Inhibitory Effect of ZC008 Active Extracts on Activated Rat Hepatic Stellate Cells." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/18611477979193822894.

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碩士<br>國立暨南國際大學<br>應用化學系<br>94<br>Liver disease is a common disease in Taiwan. Based on the statistic figures, there are more than 5,000 people died in liver cancer and 4,000 died in cirrhosis each year. Chronic liver diseases and cirrhosis are ranked the sixth of the ten leading causes of death in Taiwan. Moreover, liver cancer is the first leading cause of death of male malignant tumor, and is the second in female population, subsequent to the pneumonia. Hepatic stellate cells are activated while liver is damaged. These cells will further turn into myo-fibroblasts, which will produce lots of

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30

Wang, Chien-Chun, and 王建鈞. "The inhibitory effect of polymethoxyflavone derivatives on pancreatic tumorigenesis." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/qb94j7.

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碩士<br>嘉南藥理大學<br>生物科技系<br>105<br>Some polymethoxylated flavones, such as sinensetin (5,6,7,3',4'-pentamethoxyflavone), isolated from citrus, have been shown to possess anti-cancer activity and lower toxicity. We synthesized 4'-hydroxy-5,6,7,3'-tetramethoxyflavone, a sinensetin analog, from 3,4,5-trimethoxyphenol. The anti-tumorigenesis activity of compounds used and produced in the process of synthesis reactions was tested by soft agar colony formation assay. The results showed that all the compounds, but not 3,4,5-trimethoxyphenol and 1-(6-Hydroxy-2,3,4-trimethoxy-phenyl)-ethanone, had inhibit

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31

Hsieh, Yen-Pin, and 謝燕萍. "Synthesis of Isoflavones and Study on Tyrosinase Inhibitory effect." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/83985646446148451670.

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碩士<br>大仁科技大學<br>製藥科技研究所<br>100<br>Eight isoflavones were synthesized by one-pot approach and tested to find out the inhibiting effect to mushroom tyrosinase and B16F10 cell viability . These isoflavones were 7,8-dihydroxylated and 5,7-dihydroxylated series based on the ring A system with various ring B substitution. 7,8- dihydroxylated series includes 7,8-Dihydroxyisoflavone (1), 7,8-Dihydroxy- 4''-methoxyisoflavone (2), 7,8-Dihydroxy-3''-methoxyisoflavone (3) and 3'',7,8-Trihydroxyisoflavone (4). 5,7-dihydroxylated series includes 5,7-Dihydroxyisoflavone (5), 5,7

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32

Chan, Meng-Han, та 詹孟翰. "α-Glucosidase inhibitory effect by the extract ofAntrodia cinnamomea". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/02762973528853811650.

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碩士<br>中國文化大學<br>生物科技研究所<br>102<br>Epidemiological studies indicate that diabetes two indicators on blood sugar balance , one is fasting glucose, another is postprandial glucose level. Postprandial glucose level is more important to control blood sugar after a meal, when α-glucosidase inhibitors would reduce its effect. Taking the α-glucosidase inhibitors to manage blood glucose level result in hypoglycemic symptoms of gastrointestinal discomfort,and many studies have pointed out the synthestic of α-glucosidase inhibitors may would increase kidney tumors, severe liver injury and the occurrence

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WEI-CHIA, WANG, and 王暐嘉. "Inhibitory Effect of Soybean Peptide on Enterovirus 71 Infection." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/s3vz77.

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碩士<br>輔英科技大學<br>生物科技系碩士班<br>107<br>Enterovirus 71 is an important human pathogenic virus. Among hundreds of enteroviruses, Enterovirus 71 causes the most serious complications and deaths. Its complications include meningitis, acute cardiopulmonary failure, Acute limb paralysis syndrome. Currently there is no effective vaccine and standard treatment for enterovirus 71, therefore, prevention is usually the most important issue. Soybeans are high in nutritional value and popularity of legumes. Their peptides have been shown to have anti-cancer, antihypertensive, anti-diabetic, cholesterol-lowerin

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34

Shen, Ching-Hui, та 沈靜慧. "The Role of TNF-α in Morphine Tolerance: Effect of TNF-α inhibitor Etanercept and its therapeutic implication". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/07173379106776361678.

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博士<br>國防醫學院<br>醫學科學研究所<br>100<br>Opioids are potent and effective analgesics; they are widely used in clinical pain management. Long-term exposure to morphine leads to analgesic tolerance. There are two possible mechanisms for drug tolerance; within-system and between-system adaptation. Recent investigations on the mechanisms of within-opioid system adaptation include downregulation of G-protein coupled receptors, G protein uncoupling, and β-arrestin binding and internalization of opioid receptors. Studies of between-system adaptation have focused on glutamatergic synaptic transmission via dow

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35

Gao, Xin-Yu, and 高欣羽. "The Neighborhood Size Effect in Chinese Character Recognition：Facilitative or Inhibitory?" Thesis, 2016. http://ndltd.ncl.edu.tw/handle/m8734y.

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碩士<br>國立臺灣大學<br>心理學研究所<br>104<br>In recent years, there has been an increase of research investigating neighborhood effect in Chinese character recognition. As for whether orthographic neighborhood size (NS) effect reveals facilitative or inhibitory in Chinese character recognition, opinions vary and the question is still under debate (Bi, Hu & Weng, 2006; Zhang & Jiang, 2008; Bi & Weng, 2008; Zhang & Wang, 2010; Li, Bi & Zhang, 2010; Li, Bi, Wei & Chen, 2011). To clarify this topic, the present study implemented two experiments, the materials of which respectively were irregular & inconsisten

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Liu, Ju-Chi, and 劉如濟. "The mechanisms of inhibitory effect of trilinolein on cardiomyocyte hypertrophy." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/43977996122896897753.

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博士<br>臺北醫學大學<br>醫學研究所<br>95<br>Cardiac hypertrophy is a major clinical feature of many cardiovascular diseases. Cardiac hypertrophy can cause heart dysfunction, cardiac arrhythmia, and even sudden death. Trilinolein, an unsaturated triacylglyceride, is found in the root of Sanchi (Panax notoginseng), which has been used as a traditional herbal medicine for treating cardiovascular disorder among Chinese for hundreds of years. Previous studies have demonstrated that trilinolein possessed antioxidative ability, which protected cardiovascular cells against hypoxic injury. However, the intracellula

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Chuang, Wen-Yuan, and 莊文元. "Inhibitory Effect of LUC on Superoxide Anion Generation in Neutrophils." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/27613647530315919991.

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碩士<br>國立中興大學<br>生命科學系<br>94<br>In the present study, the inhibition of superoxide anion generation by a novel synthetic compound LUC in rat neutrophils was examined. LUC inhibited formyl-Met-Leu-Phe (fMLP)-induced superoxide anion genera¬tion in a time- and concentration-dependent manner with an IC50 value of 4.5 ± 0.6 μM. LUC had no effect on phorbol 12-myristate 13-acetate (PMA)-induced response. Inhibition by LUC was irreversible and not caused by cytotoxic effect. LUC did not scavenge the generated superoxide during dihydroxyfumaric acid (DHF) autoxidation. LUC had no effect on the phospho

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Huang, Cheng-Yi, and 黃鉦益. "Inhibitory Effect of LCY50 on Superoxide Anion Generation in Neutrophils." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/61283270964443533939.

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碩士<br>中山醫學大學<br>醫學研究所<br>92<br>LCY50 inhibited the formyl-Met-Leu-Phe (fMLP)-induced superoxide anion generation in a concentration-, with IC50 value of 10.7 ± 0.8 μM, but not time-dependent manner in rat neutrophils, while had no effect on phorbol 12-myristate 13-acetate (PMA)-induced response. The inhibition by LCY50 was reversed by washing. LCY50 did not release of lactate dehydrogenase during the reaction time. LCY50 had no effect on the superoxide anion generation during dihydroxyfumaric acid autoxidation and in arachidonic acid stimulated cell-free system. LCY50 did not affect the fMLP-s

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Hsiao, Arlene, and 蕭雅蔆. "Inhibitory Effect of TIH on Superoxide Anion Generation in Neutrophils." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/48761777305377966762.

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碩士<br>中山醫學大學<br>醫學研究所<br>92<br>A synthetic chalcone derivative TIH inhibited formyl-Met-Leu-Phe (fMLP)-induced superoxide anion generation in a time- and concentration-dependent manner in rat neutrophils with an IC50 value of 1.4 ± 0.1 μM. Inhibition by TIH was reversible and not caused by cytotoxic effect. TIH also inhibited phorbol 12-myristate 13-acetate (PMA)-induced superoxide anion generation in a concentration-dependent manner with an IC50 value of 2.8 ± 0.3 μM. TIH (1-10 μM) had no appreciable effect on the superoxide anion generation during dihydroxyfumaric acid (DHF) autoxidation, in

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Lin, Yu-Chen, and 林玉真. "Inhibitory Effect of Hinokitiol on Glycoprotein VI in Human Platelets." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/20918902917526183260.

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碩士<br>臺北醫學大學<br>醫學科學研究所<br>98<br>Hinokitiol, also known as β-thujaplicin, a tropolone derivative found in the heartwood of cupressaceous plants. Hinokitiol is a metal chelator and has various biological activities, including anti-inflammatory, anti-bacterial, and anti-tumor. It is extensively untilized as clinical products, cosmetics, and food additives. In platelets, hinokitiol acts as a potent inhibitor particularly for the platelet-type 12-lipoxygenase due to its iron chelating activity. In addition, hinokitiol has been demonstrated that it can effectively inhibit platelet aggregation induc

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Lin, Hui-Yi, and 林慧怡. "Inhibitory Effect of FAL on Superoxide Anion Generation in Neutrophils." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/47412682476218149035.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>94<br>FAL, a synthetic 2-phenyl-4-quinolone-3-carboxylic acid derivative, inhibited formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide anion generation in a concentration- and time-dependent manner in rat neutrophils with an IC50 value of 13.2 ?b 1.1 ?嵱. This inhibitory effect was not reversed by washing and not caused by cytotoxicity. FAL had no effect on phorbol 12-myristate 13-acetate (PMA)-induced superoxide anion generation in neutrophils and did not affect the superoxide generation during dihydroxyfumaric acid (DHF) autoxidation in a cell-free s

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Lin, Yu-Yun, and 林育筠. "Inhibitory effect of c-phycocyanin on melanogenesis and its inhibitorymechanism." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/51979227942957565626.

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碩士<br>國立暨南國際大學<br>生物醫學科技研究所<br>94<br>Tyrosinase catalyzes the rate-limiting reaction of melanogenesis. The formation of melanin is regulated by the activity or the expression of the enzyme. Although the whole picture of the signal transduction involved in melanogenesis remains unclear, it is suggested that cAMP plays an important role in the biosynthesis. cAMP modulates melanogenesis in three aspects. Firstly, cAMP activates the expression of microphthalmia associated transcription factor (MITF), which is the transcription factor of tyrosinase. Secondly, cAMP induces MITF degradation through t

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Liu, Wen-Der, and 劉文得. "Kinetics of Inhibitory-Substrate Biodegradation: Salinity Effect and Parameter Identifiability." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/97667247475855554191.

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博士<br>國立臺灣海洋大學<br>河海工程學系<br>94<br>Abstract Although the biodegradation of inhibitory substrates in fresh water has been extensively studied and quantified using a kinetic model, the extent and rate of the degradation of the compounds in saline water have seldom been addressed. This study investigates how salinity affects the biodegradations of three substrates: toluene (characterized with negligible inhibition), phenol (self inhibition) and trichloroethylene (TCE, competitive inhibition). Additionally, parameter identification analysis was performed using approaches of the correlation coeffici

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Chang, Yu-Hsun, and 張昱勛. "Inhibitory Effect of Phenylacetylmethionines and Related Compounds on Methionine Adenosyltransferase." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/21604329064510210528.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>89<br>Cell differentiation agent II (CDA-II), phenylacetylamino acid derivatives and related compounds were examined as potential inhibitors of methionine adenosyltransferase II (MAT II) using radioisotope analysis method. Ming-26-L (M26), Ming-27-D (M27), D-methionine, penicillin G and ethanol with significant inhibitory activity were identified. The kinetic behavior of these compounds for MAT were studied using fluorometric method. The results indicated that D-methionine was a competitive inhibitor of MAT with respect to L-methionine. The achievement supply us to e

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Chao, Hisu-Min, and 趙琇民. "Inhibitory effect of eugenol on osteoclast differentiation and bone resorption." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/18331476710149474836.

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碩士<br>國立陽明大學<br>生化暨分子生物研究所<br>98<br>Several major bone diseases are directly attributable to bone loss, including osteoporosis, bone metastasis, and rheumatoid arthritis. Osteoporosis reflected the enhancement of osteoclast activity. Therefore, blocking the differentiation and maturation of osteoclast is a possible strategy to address this problem. In this study, RAW264.7 macrophage cell line was used as cell model to find anti-osteoclastogenesis effect of essential oil. We found clove oils showed the inhibition effect of osteoclast differentiation, and identified the effective component is eu

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Shih, Chun-Hsuan, and 施珺萱. "The Inhibitory Effect of Nature Compounds fromTraditional Chinese Herbal Medicine on Metastasis of The Inhibitory Effect of Nature Compounds fromThe Inhibitory Effect of Nature Compounds from Traditional Chinese Herbal Medicine on Metastasis of Colorectal Cancer Using Cell Line SW620." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/08535177842896522281.

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碩士<br>國立臺灣大學<br>食品科技研究所<br>101<br>Colorectal cancer (CRC) is the major cancer which causes people dead worldwide. In Taiwan, according to the Bureau of Health Promotion, Department of Health, CRC has reached the first place in cancer incidence. Tumor cell metastasis is the most malignant feature during cancer progression and accounts for the major factor (90%) of mortality. Current cancer treatment includes surgery and chemotherapy, but there are still side effects and recurrence problems. Therefore, nowadays medicine profession pays more attention to the research and development of traditiona

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Huang, Wei-Ting, and 黃偉婷. "Gene Expression and Pathogen Inhibitory Effect of Antimicrobial Peptide (Monodoncin) fromGene Expression and Pathogen Inhibitory Effect of Antimicrobial Peptide (Monodoncin) from Black Tiger Shrimp (Penaeus monodon))." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/29122320809926748356.

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碩士<br>國立海洋大學<br>生物科技研究所<br>91<br>Abstract： Antimicrobial peptides（AMPs）are small cationic molecules that play an important role in innate host defense mechanism of living organisms including plants, vertebrates and invertebrates against invading microorganisms such as bacteria, fungi, parasites and virus. Monodoncin is a member of AMPs isolated from the haemocyte of black tiger shrimp, Penaeus monodon, a mature peptide with 55 residues and 5.8-kDa MW. It contains with a proline-rich amino-terminal domain and a carboxyl-domain containing six cysteines. It has an inhibitor

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"Growth inhibitory effect of docosahexaenoic acid on human melanoma A375 cells." 2007. http://library.cuhk.edu.hk/record=b5896766.

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Tong, Kit Fong.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2007.<br>Includes bibliographical references (leaves 91-104).<br>Abstracts in English and Chinese.<br>Abstract --- p.i<br>Acknowledgements --- p.vi<br>Table of Contents --- p.vii<br>List of Figures --- p.x<br>List of Tables --- p.xii<br>List of Abbreviations --- p.xiii<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter 1.1 --- Cancer --- p.2<br>Chapter 1.1.1 --- Tumor development --- p.2<br>Chapter 1.1.2 --- Cell cycle --- p.4<br>Chapter 1.1.3 --- Apoptosis --- p.9<br>Chapter 1.1.3.1 --- The extrinsic pathwa

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Tsai, Tsen, and 蔡岑. "Effect of time pressure on inhibitory brain control for emergency driving." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/qj2t37.

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碩士<br>國立交通大學<br>影像與生醫光電研究所<br>102<br>How to deal with the upcoming emergency situations is a key to avoid car accidents. Previous study (Chen, 2013) used brain imaging to reveal that the efficiency of inhibition function is responsible for copying such situations. However, other factors, such as stress, on driving inhibition are still unknown. Hence, in this study, we aim to get an insight into brain activities of emergency management in stress conditions. To investigate driver’s brain responses to inhibition function, a modified stop-signal driving task was implemented in a virtual-reality dr

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Liu, Yuh-Chyan, and 劉玉晴. "The inhibitory effect of Ocimum gratissimum L. extract on liver fibrosis." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/36022559474887951771.

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碩士<br>中山醫學大學<br>生物化學研究所<br>92<br>In this study, via the antioxidative property of Ocimum gratissimum L., we test it the effect of anti-hepatic fibrosis in vivo and in vitro. The result showed that Ocimum gratissimum L. inhibited the activation of serum induced primary hepatic stellate cells. The mRNA expression of the fibrosis factors α-SMA and collagen α (Ⅰ) were inhibited. Moreover, in animal model Ocimum gratissimum L. also inhibited the CCl4-induced liver fibrosis. The inhibition of MDA formation, collagen accumulation and α-SMA and collagen α (Ⅰ) mRNA expression, as well as the increase o

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