To see the other types of publications on this topic, follow the link: Inhibitory and tolerant effect.

Journal articles on the topic 'Inhibitory and tolerant effect'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Inhibitory and tolerant effect.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Voorde, J. Van de, S. Vyt, and B. Vanheel. "The basal endothelial inhibitory influence on vascular tone is not affected in nitroglycerin-tolerant rat aorta." Canadian Journal of Physiology and Pharmacology 72, no. 9 (1994): 1094–97. http://dx.doi.org/10.1139/y94-153.

Full text
Abstract:
Prolonged exposure to nitrovasodilators produces tolerance and dependence. Nitrovasodilators exert their action on vascular smooth muscle cells by activation of guanylyl cyclase. Nitrates share this mechanism with endothelial NO, which exerts a continuous inhibitory influence on vascular tone. Whether the basal inhibitory endothelial influence might be affected in rat aorta exposed in vitro to a tolerance-inducing concentration of nitroglycerin was investigated in this study. It was found that the basal inhibitory influence, assessed as its inhibitory influence on norepinephrine-induced contra
APA, Harvard, Vancouver, ISO, and other styles
2

Jacobs, Janette L., and George W. Sundin. "Effect of Solar UV-B Radiation on a Phyllosphere Bacterial Community." Applied and Environmental Microbiology 67, no. 12 (2001): 5488–96. http://dx.doi.org/10.1128/aem.67.12.5488-5496.2001.

Full text
Abstract:
ABSTRACT The effect of solar UV-B radiation on the population dynamics and composition of the culturable bacterial community from peanut (Arachis hypogeae L.) was examined in field studies using plants grown under UV-B−transmitting (UV-B+) or UV-B−excluding (UV-B−) plastic filters. Our data demonstrate that solar UV-B selection alters phyllosphere bacterial community composition and that UV tolerance is a prevalent phenotype late in the season. The total bacterial population size was not affected by either UV-B treatment. However, isolates from the UV-B+ plots (n = 368) were significantly more
APA, Harvard, Vancouver, ISO, and other styles
3

Georgieva, Natalia, and Ivelina Nikolova. "Allelopathic tolerance of pea cultivars to Sorghum halepense L. (Pers.) extracts." Pesticidi i fitomedicina 31, no. 1-2 (2016): 59–67. http://dx.doi.org/10.2298/pif1602059g.

Full text
Abstract:
In order to evaluate the allelopathic effect of Sorghum halepense extracts on germination and initial growth of six pea (Pisum sativum subsp. sativum, Pisum sativum subsp. arvense) cultivars and to identify tolerant cultivars, a laboratory experiment was conducted. The studied cultivars revealed different levels of susceptibility to allelopathic impact of root and aboveground biomass extracts of S. halepense. Root growth parameters (length and weight) of the pea cultivars exhibited greater susceptibility to weed extracts than stem parameters. The inhibitory effects of the extracts on germ leng
APA, Harvard, Vancouver, ISO, and other styles
4

Azevedo, Geraldo Magela, Raquel Alves Costa, Mariana Araujo Resende, Claudiney Melquiades Rodrigues, Nelson Monteiro Vaz, and Cláudia Rocha Carvalho. "Indirect Effects of Oral Tolerance Inhibit Pulmonary Granulomas toSchistosoma mansoniEggs." Clinical and Developmental Immunology 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/293625.

Full text
Abstract:
Parenteral injection of tolerated proteins into orally tolerant mice inhibits the initiation of immunological responses to unrelated proteins and blocks severe chronic inflammatory reactions of immunological origin, such as autoimmune reactions. This inhibitory effect which we have called “indirect effects of oral tolerance” is also known as “bystander suppression.” Herein, we show that i.p. injection of OVA + Al(OH)3minutes before i.v. injection ofSchistosoma mansonieggs into OVA tolerant mice blocked the increase of pulmonary granulomas. In addition, the expression of ICAM-1 in lung parenchy
APA, Harvard, Vancouver, ISO, and other styles
5

Varma, Tushar K., Tracy E. Toliver-Kinsky, Cheng Y. Lin, Aristides P. Koutrouvelis, Joan E. Nichols, and Edward R. Sherwood. "Cellular Mechanisms That Cause Suppressed Gamma Interferon Secretion in Endotoxin-Tolerant Mice." Infection and Immunity 69, no. 9 (2001): 5249–63. http://dx.doi.org/10.1128/iai.69.9.5249-5263.2001.

Full text
Abstract:
ABSTRACT Endotoxin (lipopolysaccharide [LPS]) tolerance is a state of altered immunity characterized, in part, by suppression of LPS-induced gamma interferon (IFN-γ) expression. However, the cellular mediators regulating LPS-induced production of IFN-γ in normal mice and the effect of LPS tolerance on these mediators has not been well characterized. Our studies show that macrophage dysfunction is the primary factor causing suppressed IFN-γ expression in LPS-tolerant mice. Specifically, LPS-tolerant macrophages have a markedly impaired ability to induce IFN-γ secretion by T cells and NK cells o
APA, Harvard, Vancouver, ISO, and other styles
6

Nguyen, Uyen T., Iwona B. Wenderska, Matthew A. Chong, Kalinka Koteva, Gerard D. Wright, and Lori L. Burrows. "Small-Molecule Modulators of Listeria monocytogenes Biofilm Development." Applied and Environmental Microbiology 78, no. 5 (2011): 1454–65. http://dx.doi.org/10.1128/aem.07227-11.

Full text
Abstract:
ABSTRACTListeria monocytogenesis an important food-borne pathogen whose ability to form disinfectant-tolerant biofilms on a variety of surfaces presents a food safety challenge for manufacturers of ready-to-eat products. We developed here a high-throughput biofilm assay forL. monocytogenesand, as a proof of principle, used it to screen an 80-compound protein kinase inhibitor library to identify molecules that perturb biofilm development. The screen yielded molecules toxic to multiple strains ofListeriaat micromolar concentrations, as well as molecules that decreased (≤50% of vehicle control) o
APA, Harvard, Vancouver, ISO, and other styles
7

Alguacil, L. F., M. P. Lopez-Ruiz, J. C. Prieto, C. Alamo, and E. Cuenca. "Effect of morphine and acetylcholine on contractile activity and cyclic AMP in guinea-pig ileum." Bioscience Reports 10, no. 1 (1990): 113–19. http://dx.doi.org/10.1007/bf01116859.

Full text
Abstract:
Neither acute nor prolonged exposure to morphine altered cAMP content or spontaneous movements of longitudinal muscle-myenteric plexus strips of the guinea-pig ileum. By contrast, exogenous acetylcholine or electrical stimulation of the strips elicited both a decrease of cAMP concentration and a twitch response. Atropine blocked the effects of stimulation on these parameters. Addition of morphine to electrically stimulated strips inhibited the twitch response but did not affect cAMP levels. Incubation with morphine led to the development of tolerance to the inhibitory effect on twitch activity
APA, Harvard, Vancouver, ISO, and other styles
8

El-Masry, Eman A., Ahmed E. Taha, and Soma E. Ajlan. "The Effect of Triclosan Adaptation on Antimicrobial Resistance among Clinical Escherichia coli Isolates from Egyptian Patients." Journal of Pure and Applied Microbiology 15, no. 4 (2021): 2394–402. http://dx.doi.org/10.22207/jpam.15.4.64.

Full text
Abstract:
There is a possible link between exposure to Triclosan (TCS) and changes in antimicrobial susceptibility. The change in the tolerance of clinical Escherichia coli (n=45) isolates to the biocide TCS, changes in antibiotic resistance and differences in the efflux pump mechanism were analyzed. 45 E. coli isolates were obtained. The minimum inhibitory concentration (MIC), the minimum bactericidal concentration (MBC) of TCS, and the expression of four efflux pump encoding genes in antibiotic-resistant isolates were determined before and after TCS adaptation. The number of TCS-tolerant isolates was
APA, Harvard, Vancouver, ISO, and other styles
9

Chanda, Kakoli, Atifa Begum Mozumder, Ringhoilal Chorei, Ridip Kumar Gogoi, and Himanshu Kishore Prasad. "A Lignocellulolytic Colletotrichum sp. OH with Broad-Spectrum Tolerance to Lignocellulosic Pretreatment Compounds and Derivatives and the Efficiency to Produce Hydrogen Peroxide and 5-Hydroxymethylfurfural Tolerant Cellulases." Journal of Fungi 7, no. 10 (2021): 785. http://dx.doi.org/10.3390/jof7100785.

Full text
Abstract:
Fungal endophytes are an emerging source of novel traits and biomolecules suitable for lignocellulosic biomass treatment. This work documents the toxicity tolerance of Colletotrichum sp. OH toward various lignocellulosic pretreatment-derived inhibitors. The effects of aldehydes (vanillin, p-hydroxybenzaldehyde, furfural, 5-hydroxymethylfurfural; HMF), acids (gallic, formic, levulinic, and p-hydroxybenzoic acid), phenolics (hydroquinone, p-coumaric acid), and two pretreatment chemicals (hydrogen peroxide and ionic liquid), on the mycelium growth, biomass accumulation, and lignocellulolytic enzy
APA, Harvard, Vancouver, ISO, and other styles
10

Khan, Mohd Kamran, Anamika Pandey, Mehmet Hamurcu, et al. "Nutrient Homeostasis of Aegilops Accessions Differing in B Tolerance Level under Boron Toxic Growth Conditions." Biology 11, no. 8 (2022): 1094. http://dx.doi.org/10.3390/biology11081094.

Full text
Abstract:
Boron (B) is a crucial microelement for several biological processes in plants; however, it becomes hazardous when present in excess in the soil. B toxicity adversely affects the wheat yield all around the world, particularly in the arid and semiarid regions. Aegilops, the nearest wild wheat relatives, could be an efficient source to develop B toxicity tolerance in modern cultivars. However, to potentially utilize these species, it is necessary to understand the underlying mechanisms that are involved in providing them tolerance. Other than hampering cellular and physiological activities, high
APA, Harvard, Vancouver, ISO, and other styles
11

Oláhné Horváth, B., E. Fazekas, N. Kellner, and I. Magyar. "Influence of medium chain fatty acids on some botrytised wine-related yeast species and on spontaneous refermentation of Tokaj essence." Acta Alimentaria 49, no. 3 (2020): 339–47. http://dx.doi.org/10.1556/066.2020.49.3.13.

Full text
Abstract:
Medium chain fatty acids are candidates of partial sulphur dioxide replacement in wine, as a solution to the growing consumer concerns about chemical additives. In botrytised sweet wine specialties, large amount of sulphur dioxide addition is one of the effective practices to stop alcoholic fermentation. Increasing medium chain fatty acid levels up to 80 mg l-1 was tested as a sole inhibitor on solid agar surface. S. bacillaris seemed to be the most sensitive, S. cerevsisiae and S. bayanus were more tolerant, while Z. bailii showed the highest tolerance. Then, increasing medium chain fatty aci
APA, Harvard, Vancouver, ISO, and other styles
12

Rangaraj, N., H. Kalant та F. Beaugé. "α1-Adrenergic receptor involvement in norepinephrine–ethanol inhibition of rat brain Na+-K+ ATPase and in ethanol tolerance". Canadian Journal of Physiology and Pharmacology 63, № 9 (1985): 1075–79. http://dx.doi.org/10.1139/y85-176.

Full text
Abstract:
Norepinephrine (NE) sensitization of rat brain Na+–K+ ATPase to ethanol (EtOH) inhibition appears to be mediated by α1-adrenoreceptors, since it was reversed by prazosin and WB-4101 (α1-receptor antagonists) in a concentration-dependent manner, but not by yohimbine and piperoxan (α2-receptor antagonists). In addition, clonidine (α2-agonist) and methoxamine (central receptor type uncertain) produced very little sensitization. Chronic EtOH administration to rats for 3 weeks produced tolerance to the hypothermic effect of test doses of EtOH (3 g/kg, i.p.) and a decreased inhibitory effect of NE +
APA, Harvard, Vancouver, ISO, and other styles
13

Mathur, Megha, Neha Rawat, Tanushree Saxena, et al. "Effect of Arsenic on Fluoride Tolerance in Microbacterium paraoxydans Strain IR-1." Toxics 11, no. 11 (2023): 945. http://dx.doi.org/10.3390/toxics11110945.

Full text
Abstract:
Fluoride (F) and arsenic (As) are two major contaminants of water and soil systems around the globe, causing potential toxicity to humans, plants, animals, and microbes. These contaminated soil systems can be restored by microorganisms that can tolerate toxic stress and provide rapid mineralization of soil, organic matter, and contaminants, using various tolerance mechanisms. Thus, the present study was undertaken with the arsenic hyper-tolerant bacterium Microbacterium paraoxydans strain IR-1 to determine its tolerance and toxicity to increasing doses of fluoride, either individually or in co
APA, Harvard, Vancouver, ISO, and other styles
14

Kang, Joyeon, Doyeon Lee, Kyoung Jin Lee, et al. "Tumor-Suppressive Effect of Metformin via the Regulation of M2 Macrophages and Myeloid-Derived Suppressor Cells in the Tumor Microenvironment of Colorectal Cancer." Cancers 14, no. 12 (2022): 2881. http://dx.doi.org/10.3390/cancers14122881.

Full text
Abstract:
Myeloid-derived suppressor cells (MDSCs) and M2 macrophages in the tumor microenvironment contribute to tumor progression by inducing immune tolerance to tumor antigens and cancer cells. Metformin, one of the most common diabetes drugs, has shown anti-inflammatory and anti-tumor effects. However, the effects of metformin on inflammatory cells of the tumor microenvironment and its underlying mechanisms remain unclarified. In this study, we investigated the effect of metformin on M2 macrophages and MDSCs using monocyte THP-1 cells and a dextran sodium sulfate (DSS)-treated ApcMin/+ mouse model o
APA, Harvard, Vancouver, ISO, and other styles
15

El Rasafi, Taoufik, Mohamed Nouri, Said Bouda, and Abdelmajid Haddioui. "The Effect of Cd, Zn and Fe on Seed Germination and Early Seedling Growth of Wheat and Bean." Ekológia (Bratislava) 35, no. 3 (2016): 213–23. http://dx.doi.org/10.1515/eko-2016-0017.

Full text
Abstract:
AbstractThis study was conducted to evaluate the effect of metals on wheat and bean species. The method uses seed germination and early seedling growth of these plants in the presence of various levels (10, 50, 100, 250, 500, 750 and 1000 mg/L) of Cadmium (Cd), Iron (Fe) and Zinc (Zn). The inhibition caused by these metals was depending on the concentration used, the metal itself and the plant species. The species had reduced seed germination, root and shoot lengths, tolerance index and percentphyto-toxicity with increasing concentrations of metals. Cadmium was determined to be the most inhibi
APA, Harvard, Vancouver, ISO, and other styles
16

Tereshchenko, T. V., O. O. Zholobova, and I. V. Mogilevskaya. "In vitro study of the effect of NaCl on interspecific Populus L. hybrids." Agricultural Science Euro-North-East 26, no. 2 (2025): 295–305. https://doi.org/10.30766/2072-9081.2025.26.2.295-305.

Full text
Abstract:
In conditions of climate aridisation and desertification of territories leading to secondary soil salinisation, more and more lands are subjected to premature degradation and their further withdrawal from agricultural use. In vitro modelling of stress factors for selection of tolerant lines of salt-tolerant genotypes of tree species helps to accelerate the breeding process. In the study, the effect of NaCl on morphogenesis of regenerant plants of poplar F1 interspecific hybrids (Populus L.) was investigated, and in vitro selection of potentially co-tolerant genotypes was carried out. After con
APA, Harvard, Vancouver, ISO, and other styles
17

Xu, Bin, Brett Kaiser, and Roland K. Strong. "Dissecting the integration of Natural Killer cell receptor signaling (41.52)." Journal of Immunology 182, no. 1_Supplement (2009): 41.52. http://dx.doi.org/10.4049/jimmunol.182.supp.41.52.

Full text
Abstract:
Abstract Natural Killer cell is a major component of the innate immune system. It plays important roles in rejection of cancerous and viral-infected cells. NK cells express numerous surface receptors that can be activating or inhibitory. To investigate how activating and inhibitory NK receptors integrate signals in the decision to activate or to be tolerant, we studied the activating/inhibitory effects of NKG2D-MIC and NKG2A/CD94-peptide-HLA-E pathways, both alone or in combination using human NKL leukemia cell line and in vitro purified protein ligands. Our results demonstrate NKG2D receptors
APA, Harvard, Vancouver, ISO, and other styles
18

Chen, Peiwen, Yichun Zhu, Jieyuan Yang, and Yafen Lai. "Effect of Low-intensity Ultrasound on Cd Tolerance of Partial Nitrification Sludge." Journal of Physics: Conference Series 2468, no. 1 (2023): 012133. http://dx.doi.org/10.1088/1742-6596/2468/1/012133.

Full text
Abstract:
Abstract Cadmium (Cd) is a typical nitrification inhibitor, which has a strong inhibitory effect on partial nitrification (PN). The discrepancy on Cd tolerance of PN sludge caused by low-intensity ultrasound (LIU) was studied. It suggested that the half inhibitory concentration (IC50) of sludge was increased from 24.51 to 29.07 mg/L by 35 days of ultrasonic treatment, and the Cd tolerance of sludge was enhanced. Further analysis indicated that contents of extracellular polymeric substances (EPS) rose substantially because of LIU, which played a catalytic role on increasing adsorption capacity
APA, Harvard, Vancouver, ISO, and other styles
19

Haneda, K., K. Sano, G. Tamura, T. Sato, S. Habu, and K. Shirato. "TGF-beta induced by oral tolerance ameliorates experimental tracheal eosinophilia." Journal of Immunology 159, no. 9 (1997): 4484–90. http://dx.doi.org/10.4049/jimmunol.159.9.4484.

Full text
Abstract:
Abstract Induction of peripheral tolerance is one of the feasible approaches for the control of autoimmunities and allergies. Therapeutic applications of oral tolerance to autoimmunities are in progress both experimentally and clinically, while those to allergies have been poorly investigated. We examined the induction of CD4+ T cells with suppressive properties by oral tolerance and the mechanism by which these cells down-regulated Ag-induced eosinophilia in the trachea. Feeding of mice transgenic for anti-OVA TCR with high doses of OVA inhibited the airway eosinophilic inflammation induced b
APA, Harvard, Vancouver, ISO, and other styles
20

Ratz, Jodan D., Michael A. Adams, and Brian M. Bennett. "Effect of in vivo nitrate tolerance on hypersensitivity to NO donors after NO-synthase blockade." Canadian Journal of Physiology and Pharmacology 80, no. 11 (2002): 1106–18. http://dx.doi.org/10.1139/y02-141.

Full text
Abstract:
Animals treated with nitric oxide synthase (NOS) inhibitors exhibit marked hypersensitivity to the blood pressure lowering effects of exogenous nitric oxide (NO) donors. We used this model as a sensitive index to evaluate the relative importance of reduced biotransformation of glyceryl trinitrate (GTN) to NO in the development of nitrate tolerance. NOS-blockade hypertension using NG-nitro-L-arginine methyl ester (L-NAME) caused a marked enhancement of the mean arterial pressure (MAP) decrease mediated by GTN in nontolerant rats. However, even large doses of GTN were unable to change the MAP in
APA, Harvard, Vancouver, ISO, and other styles
21

L., I. Storozhyk, I. Voitovska V., S. Tereshchenko I., and V. Zavhorodnia S. "Biochemical composition and allelopathic properties of sweet sorghum seeds [Sorghum bicolor (L.) Moench]." Plant varieties studying and protection 18, no. 1 (2022): 66–74. https://doi.org/10.21498/2518-1017.18.1.2022.257589.

Full text
Abstract:
<strong>Aim.</strong>&nbsp;To establish the main composition of allelochemicals and the activity of their aqueous extracts from sweet sorghum seeds &ndash; hybrids with high and medium sugar content &lsquo;Sugargraze ARG&rsquo; (Argentina), &lsquo;Sioux&rsquo; (USA) and &lsquo;Ananas&rsquo; (Ukraine) on germination energy and seed germination of test crops (peas, clover). <strong>Methods.</strong>&nbsp;Allelopathic, physiological-biochemical, agrochemical and statistical methods were used. The allelopathic activity of extracts (water-soluble) from the seeds of the studied sorghum hybrids was d
APA, Harvard, Vancouver, ISO, and other styles
22

Qureshi, Asad Sarwar, and Ashenafi Worku Daba. "Evaluating Growth and Yield Parameters of Five Quinoa (Chenopodium quinoa W.) Genotypes Under Different Salt Stress Conditions." Journal of Agricultural Science 12, no. 3 (2020): 128. http://dx.doi.org/10.5539/jas.v12n3p128.

Full text
Abstract:
Soil salinization is a global problem which restricts the choice of crop for cultivation. Management and reclamation of salinity using costly techniques may not be affordable by subsistence farmers. Therefore, it is important to look for new alternate crops like &amp;ldquo;quinoa&amp;rdquo; which are more salt-tolerant. As crops vary in their tolerance to salinity, they need to be evaluated for different salinity conditions. This study was conducted to evaluate five quinoa (Chenopodium quinoa W.) genotypes (ICBA-Q1, ICBA-Q2), ICBA-Q3, ICBA-Q4 and ICBA-Q5) for salinity tolerance under four arti
APA, Harvard, Vancouver, ISO, and other styles
23

Aoki, Terumichi, and Kinji Uchida. "Inhibitory effect of sodium chloride on methylammonium uptake by a salt-tolerant yeast: Zygosaccharomyces rouxii." Journal of Fermentation and Bioengineering 72, no. 2 (1991): 87–91. http://dx.doi.org/10.1016/0922-338x(91)90314-7.

Full text
APA, Harvard, Vancouver, ISO, and other styles
24

Parera, Victoria, Carlos Alberto Parera, and Gabriela Egly Feresin. "Germination and Early Seedling Growth of High Andean Native Plants under Heavy Metal Stress." Diversity 15, no. 7 (2023): 824. http://dx.doi.org/10.3390/d15070824.

Full text
Abstract:
The development of large-scale mining activity along the Central Andes of Argentina (CAA) has generated significant amounts of waste materials containing heavy metals. Phytoremediation is a promising eco-friendly, low-cost, and effective technology for the removal of heavy metals. The present study aimed to identify two native dominant species from the CCA, Adesmia subterranea and A. pinifolia, as metal-tolerant plant species for the first time, by evaluating the germination and early seedling growth at different concentrations (ppm) of Cd (3, 4.5 and 6), Ni (150, 225 and 300), As (20, 30 and
APA, Harvard, Vancouver, ISO, and other styles
25

MANDAL, MP, SANJAY KUMAR MANDAL, and KIRAN KIRAN. "Allelopathic effects of medicinal plant species on seed germination and seedling growth of wheat varieties." Journal of Medicinal and Aromatic Plant Sciences 37, no. 2 (2015): 35–40. http://dx.doi.org/10.62029/jmaps.v37i2.mandal.

Full text
Abstract:
Allelopathic effect of three medicinal plant species viz. Costus speciosus, Tinospora cordifolia and Coleus forskohli was examined on seed germination and seedling growth of four popular varieties (Pusa gold, HD2733, VL-914, RSP 561) of wheat (Triticum aestivum L.). The aqueous leaf extracts reduced the seed germination and seedling growth of wheat. On the basis of value of per cent reduction in seed germination and germination relative index (GRI), the inhibitory effect of different leaf extracts was maximum in susceptible varieties (VL-914&amp; RSP 561) followed by tolerant varieties (Pusa g
APA, Harvard, Vancouver, ISO, and other styles
26

Mauser-Bunschoten, EP, HK Nieuwenhuis, G. Roosendaal, and HM van den Berg. "Low-dose immune tolerance induction in hemophilia A patients with inhibitors." Blood 86, no. 3 (1995): 983–88. http://dx.doi.org/10.1182/blood.v86.3.983.983.

Full text
Abstract:
Abstract In patients with hemophilia A and inhibitory alloantibodies against factor VIII, various dosage schedules are used to obtain immune tolerance. In this study, we have evaluated the results of 13 years of low-dose immune tolerance induction and factors that are predictive of a positive result. The effect of immune tolerance induction in relation to age at inhibitor development, number of exposure days, age at start of therapy, maximum inhibitor titer, factor VIII products involved, and virologic status were determined. We evaluated 24 patients with severe hemophilia A and inhibitors who
APA, Harvard, Vancouver, ISO, and other styles
27

Mauser-Bunschoten, EP, HK Nieuwenhuis, G. Roosendaal, and HM van den Berg. "Low-dose immune tolerance induction in hemophilia A patients with inhibitors." Blood 86, no. 3 (1995): 983–88. http://dx.doi.org/10.1182/blood.v86.3.983.bloodjournal863983.

Full text
Abstract:
In patients with hemophilia A and inhibitory alloantibodies against factor VIII, various dosage schedules are used to obtain immune tolerance. In this study, we have evaluated the results of 13 years of low-dose immune tolerance induction and factors that are predictive of a positive result. The effect of immune tolerance induction in relation to age at inhibitor development, number of exposure days, age at start of therapy, maximum inhibitor titer, factor VIII products involved, and virologic status were determined. We evaluated 24 patients with severe hemophilia A and inhibitors who were tre
APA, Harvard, Vancouver, ISO, and other styles
28

Bie, Bihua, and Zhizhong Z. Pan. "Increased Glutamate Synaptic Transmission in the Nucleus Raphe Magnus Neurons from Morphine-Tolerant Rats." Molecular Pain 1 (January 1, 2005): 1744–8069. http://dx.doi.org/10.1186/1744-8069-1-7.

Full text
Abstract:
Currently, opioid-based drugs are the most effective pain relievers that are widely used in the treatment of pain. However, the analgesic efficacy of opioids is significantly limited by the development of tolerance after repeated opioid administration. Glutamate receptors have been reported to critically participate in the development and maintenance of opioid tolerance, but the underlying mechanisms remain unclear. Using whole-cell voltage-clamp recordings in brainstem slices, the present study investigated chronic morphine-induced adaptations in glutamatergic synaptic transmission in neurons
APA, Harvard, Vancouver, ISO, and other styles
29

Oren, Nadav, Stefan Timm, Marcus Frank, Oliver Mantovani, Omer Murik, and Martin Hagemann. "Red/far-red light signals regulate the activity of the carbon-concentrating mechanism in cyanobacteria." Science Advances 7, no. 34 (2021): eabg0435. http://dx.doi.org/10.1126/sciadv.abg0435.

Full text
Abstract:
Desiccation-tolerant cyanobacteria can survive frequent hydration/dehydration cycles likely affecting inorganic carbon (Ci) levels. It was recently shown that red/far-red light serves as signal-preparing cells toward dehydration. Here, the effects of desiccation on Ci assimilation by Leptolyngbya ohadii isolated from Israel’s Negev desert were investigated. Metabolomic investigations indicated a decline in ribulose-1,5-bisphosphate carboxylase/oxygenase carboxylation activity, and this was accelerated by far-red light. Far-red light negatively affected the Ci affinity of L. ohadii during desic
APA, Harvard, Vancouver, ISO, and other styles
30

Dorotenko, A. R., I. M. Sukhanov, A. A. Savchenko, O. A. Dravolina, and I. V. Belozertseva. "Tolerance to paradoxical increase in motor activity caused by inhibition of phosphodiesterase 10a in a model of hypodopaminergy." Scientific Notes of the Pavlov University 30, no. 4 (2023): 32–42. http://dx.doi.org/10.24884/1607-4181-2023-30-4-32-42.

Full text
Abstract:
Introduction. Phosphodiesterases (PDEs) are a group of enzymes that hydrolyze the phosphodiester bond in cyclic nucleotides. PDE10A is mainly present in the medium-sized spiny neurons of the striatum. Functionally, PDE10A inhibition imitates the effect of D1-like agonists and D2-like dopamine receptor antagonists, and simultaneously modulating “direct” and “indirect” striato-thalamo-cortical brain pathway. To date, the effects of PDE10A inhibition have been characterized mainly, reproducing the inhibitory motor activity of D2-like dopamine receptor antagonists.The objective was to evaluate the
APA, Harvard, Vancouver, ISO, and other styles
31

Ferreira, Mariana AM, Maria LS Pereira, and Kênia V. dos Santos. "Drug-induced tolerance: the effects of antibiotic pre-exposure in Stenotrophomonas maltophilia." Future Microbiology 15, no. 7 (2020): 497–508. http://dx.doi.org/10.2217/fmb-2019-0253.

Full text
Abstract:
Aim: To investigate if the prior use of nontargeted antibiotics induces cross-tolerance in Stenotrophomonas maltophilia. Methods: Antibiotic induction was performed to evaluate daptomycin and vancomycin as possible tolerance-inducing drugs measured by minimum bactericidal concentration/minimum inhibitory concentration (MIC) ratio, adapted disk-diffusion tests and time–kill curves. Results: After antibiotic exposure, three potentially tolerant strains were isolated, maintaining the same MIC value of levofloxacin, with minimum bactericidal concentration/MIC ratio slightly higher than the parenta
APA, Harvard, Vancouver, ISO, and other styles
32

Ng, Gervase, Jonathan Yeow, Jiangtao Xu, and Cyrille Boyer. "Application of oxygen tolerant PET-RAFT to polymerization-induced self-assembly." Polymer Chemistry 8, no. 18 (2017): 2841–51. http://dx.doi.org/10.1039/c7py00442g.

Full text
Abstract:
The inhibitory effects of molecular oxygen in PET-RAFT polymerization can be overcome by the addition of singlet oxygen quenchers. This oxygen tolerant approach is compatible with a range of organic solvents and can be used to synthesize nanoparticles according to a PISA process.
APA, Harvard, Vancouver, ISO, and other styles
33

Ghezel Sefloo, Negar, Krzysztof Wieczorek, Siegrid Steinkellner, and Karin Hage-Ahmed. "Serendipita Species Trigger Cultivar-Specific Responses to Fusarium Wilt in Tomato." Agronomy 9, no. 10 (2019): 595. http://dx.doi.org/10.3390/agronomy9100595.

Full text
Abstract:
The endophytic fungi Serendipita indica and S. vermifera have recently gained increasing attention due to their beneficial effects on plant growth and plant health. Little is known about other species, such as S. williamsii and S. herbamans. To test their biocontrol and growth-promoting potential, susceptible and tolerant tomato cultivars (Kremser Perle and Micro-Tom, respectively) were inoculated with S. williamsii, S. herbamans, S. indica, or S. vermifera and challenged with the soilborne pathogen Fusarium oxysporum f. sp. lycopersici (Fol) in greenhouse experiments. Furthermore, in vitro as
APA, Harvard, Vancouver, ISO, and other styles
34

Scott, Jon E., Leslie A. Weston, Joseph Chappell, and Kathleen Hanley. "Effects of Clomazone on IPP Isomerase and Prenyl Transferase Activities in Cell Suspension Cultures and Cotyledons of Solanaceous Species." Weed Science 42, no. 4 (1994): 509–16. http://dx.doi.org/10.1017/s0043174500076864.

Full text
Abstract:
Laboratory assays were conducted to determine the sensitivity of tomato and tobacco cell suspension cultures and tomato and pepper cotyledons to clomazone. A comparison of fresh weight and carotenoid content indicated up to a three-fold difference between the clomazone-tolerant tobacco and clomazone-susceptible tomato cell suspension cultures. In contrast, an approximate 60-fold difference between the tolerant pepper and susceptible tomato cotyledons was observed when total chlorophyll and carotenoid contents were measured. The effect of clomazone and its possible metabolites on in vivo and in
APA, Harvard, Vancouver, ISO, and other styles
35

Björklund, Andreas T., Marie Schaffer, Cyril Fauriat, et al. "NK cells expressing inhibitory KIR for non–self-ligands remain tolerant in HLA-matched sibling stem cell transplantation." Blood 115, no. 13 (2010): 2686–94. http://dx.doi.org/10.1182/blood-2009-07-229740.

Full text
Abstract:
Abstract Natural killer (NK)–cell alloreactivity in recipients of hematopoietic stem cell grafts from HLA-identical siblings is intriguing and has suggested breaking of NK-cell tolerance during the posttransplantation period. To examine this possibility, we analyzed clinical outcomes in a cohort of 105 patients with myeloid malignancies who received T cell–replete grafts from HLA-matched sibling donors. Presence of inhibitory killer cell immunoglobulin-like receptors (KIRs) for nonself HLA class I ligands had no effect on disease-free survival, incidence of relapse, or graft-versus-host diseas
APA, Harvard, Vancouver, ISO, and other styles
36

White, Kylie, Gina Nicoletti, and Hugh Cornell. "Antibacterial Profile of a Microbicidal Agent Targeting Tyrosine Phosphatases and Redox Thiols, Novel Drug Targets." Antibiotics 10, no. 11 (2021): 1310. http://dx.doi.org/10.3390/antibiotics10111310.

Full text
Abstract:
The activity profile of a protein tyrosine phosphatase (PTP) inhibitor and redox thiol oxidant, nitropropenyl benzodioxole (NPBD), was investigated across a broad range of bacterial species. In vitro assays assessed inhibitory and lethal activity patterns, the induction of drug variants on long term exposure, the inhibitory interactions of NPBD with antibiotics, and the effect of plasma proteins and redox thiols on activity. A literature review indicates the complexity of PTP and redox signaling and suggests likely metabolic targets. NPBD was broadly bactericidal to pathogens of the skin, resp
APA, Harvard, Vancouver, ISO, and other styles
37

Iturritxa, Eugenia, Nebai Mesanza, and María-Jesús Torija. "The Potential of Wild Yeasts as Promising Biocontrol Agents against Pine Canker Diseases." Journal of Fungi 9, no. 8 (2023): 840. http://dx.doi.org/10.3390/jof9080840.

Full text
Abstract:
Native wild yeasts from forest ecosystems represent an interesting potential source of biocontrol organisms in synergy with disease-tolerant forest materials. Yeasts have a combination of competitive mechanisms and low requirements for their biotechnological application as biocontrol agents. The current study aimed to increase the number of biocontrol candidates against Fusarium circinatum and Diplodia sapinea. The enzymatic and antagonistic activities of the biocontrol candidates were evaluated using different screening methods, in which the direct impact on the growth of the pathogen was mea
APA, Harvard, Vancouver, ISO, and other styles
38

Dias, Mirela B., Maria C. Almeida, Evelin C. Carnio, and Luiz G. S. Branco. "Role of nitric oxide in tolerance to lipopolysaccharide in mice." Journal of Applied Physiology 98, no. 4 (2005): 1322–27. http://dx.doi.org/10.1152/japplphysiol.01243.2004.

Full text
Abstract:
The injection of repeated doses of lipopolysaccharide (LPS) results in attenuation of the febrile response, which is called endotoxin tolerance. We tested the hypothesis that nitric oxide (NO) arising from inducible NO synthase (iNOS) plays a role in endotoxin tolerance, using not only pharmacological trials but also genetically engineered mice. Body core temperature was measured by biotelemetry in mice treated with NG-monomethyl-l-arginine (l -NMMA, 40 mg/kg; a nonselective NO synthase inhibitor) or aminoguanidine (AG, 10 mg/kg; a selective iNOS inhibitor) and in mice deficient in the iNOS ge
APA, Harvard, Vancouver, ISO, and other styles
39

Smith, Alison J., Michael K. Hancock, Kun Bi, John Andrews, Paula Harrison, and Tristan J. Vaughan. "Feasibility of Implementing Cell-Based Pathway Reporter Assays in Early High-Throughput Screening Assay Cascades for Antibody Drug Discovery." Journal of Biomolecular Screening 17, no. 6 (2012): 713–26. http://dx.doi.org/10.1177/1087057112442962.

Full text
Abstract:
Implementing functional cell-based screens in early antibody discovery has become increasingly important to select antibodies with the desired profile. However, this is limited by assay tolerance to crude antibody preparations and assay sensitivity. The current study aims to address this challenge and identify routes forward. Two common types of high-throughput screening (HTS) antibody sample, derived from either phage display or hybridoma techniques, have been screened across a wide range of CellSensor beta-lactamase reporter assays in a variety of cell backgrounds to more extensively charact
APA, Harvard, Vancouver, ISO, and other styles
40

Alhaddad, Fedae, Talaat Ahmed, Samir Jaoua, Mohammad A. Al-Ghouti, Roda Al-Thani, and Mohammed Abu-Dieyeh. "Isolation of the Endophytic Fungus Aspergillus terreus from a Halophyte (Tetraena qatarensis) and Assessment of Its Potential in Tomato Seedling Protection." Plants 13, no. 16 (2024): 2218. http://dx.doi.org/10.3390/plants13162218.

Full text
Abstract:
Living in diverse environmentally harsh conditions, the plant exhibits a unique survival mechanism. As a result, the endophytes residing within the plant produce specific compounds that promote the plant’s growth and defend it against pathogens. Plants and algae symbiotically harbor endophytes, i.e., microbes and microorganisms living within them. The objective of this study is to isolate endophytic fungi, specifically strains of Aspergillus terreus, from the leaves of the salt-tolerant plant Tetraena qatarensis and to explore the salt tolerance, antagonistic activity, and growth promotion pro
APA, Harvard, Vancouver, ISO, and other styles
41

Azuma, Momoyo, Keiji Murakami, Rina Murata, et al. "Clinical Significance of Carbapenem-Tolerant Pseudomonas aeruginosa Isolated in the Respiratory Tract." Antibiotics 9, no. 9 (2020): 626. http://dx.doi.org/10.3390/antibiotics9090626.

Full text
Abstract:
We often come across difficult to treat infections—even after administering appropriate antibiotics according to the minimal inhibitory concentration of the causative bacteria. Antibiotic tolerance has recently started to garner attention as a crucial mechanism of refractory infections. However, few studies have reported the correlation between clinical outcomes and antibiotic tolerance. This study aims to clarify the effect of antibiotic tolerance on clinical outcomes of respiratory tract infection caused by Pseudomonas aeuginosa (P. aeruginosa). We examined a total of 63 strains isolated fro
APA, Harvard, Vancouver, ISO, and other styles
42

Gao, Canhong, Mohamed S. Sheteiwy, Chen Lin, Yajing Guan, Zaid Ulhassan, and Jin Hu. "Spermidine Suppressed the Inhibitory Effects of Polyamines Inhibitors Combination in Maize (Zea mays L.) Seedlings under Chilling Stress." Plants 10, no. 11 (2021): 2421. http://dx.doi.org/10.3390/plants10112421.

Full text
Abstract:
Chilling stress greatly inhibited the seed germination, plant growth, development and productivity in this study. The current research aimed to study the effects of different polyamine (PA) inhibitor combinations (Co), e.g., D-arginine (D-Arg), difluoromethylormithine (DFMO), aminoguanidine (Ag) and methylglyoxyl–bis-(guanyhydrazone) (MGBG) at different doses, i.e., 10 µM Co, 100 µM Co, 500 µM Co, 1000 µM Co and 1000 µM Co + 1 mM Spd (Spermidine) in two inbred lines of maize (Zea mays L.), i.e., Mo17 and Huang C, a sensitive and tolerant chilling stress, respectively. The combination treatment
APA, Harvard, Vancouver, ISO, and other styles
43

Flores-Bocanegra, Laura, Rafael Torres-Colín, Martin González-Andrade, José S. Calderón та Rachel Mata. "In Vivo and In Vitro α-Glucosidase Inhibitory Activity of Perfoliatin a from Melampodium Perfoliatum". Natural Product Communications 14, № 1 (2019): 1934578X1901400. http://dx.doi.org/10.1177/1934578x1901400102.

Full text
Abstract:
As part of our effort to discover new α-glucosidase inhibitors from natural sources, it was found that an aqueous extract from Melampodium perfoliatum (Cavanilles) Kunth (Asteraceae) inhibited the activity of rat-intestinal α-glucosidases in a concentration dependent manner (IC50= 958 μg/mL). Fractionation of the active extract led to the isolation of perfoliatin A (1), which was active against the mammal α-glucosidases and a recombinant α-glucosidase with maltase-glucoamylase activity obtained from Ruminococcus obeum. Kinetic analysis revealed that the interaction of 1 with R. obeum-α-glucosi
APA, Harvard, Vancouver, ISO, and other styles
44

Singer, Susan R., and Carl N. McDaniel. "Analyzing growth in cell cultures. II. Effect of initial cell mass on growth." Canadian Journal of Botany 64, no. 1 (1986): 238–41. http://dx.doi.org/10.1139/b86-034.

Full text
Abstract:
Numerous factors must be considered when analyzing growth in a cultured cell system. One extremely critical factor is the initial cell mass. The effect of initial mass (10 to 400 mg) on growth rate was assessed for cell lines tolerant and susceptible to the herbicides 3-amino-1,2,4-triazole (amitrole) and N-(phosphonomethyl)glycine (glyphosate). For a given cell line, the relationship between initial mass and growth rate was comparable in the presence and absence of the growth inhibitors. However, among cell lines the response varied. For one amitrole- and glyphosate-tolerant cell line, increa
APA, Harvard, Vancouver, ISO, and other styles
45

Mashima, Tetsuo, Risa Iwasaki, Naomi Kawata, et al. "In silico chemical screening identifies epidermal growth factor receptor as a therapeutic target of drug-tolerant CD44v9-positive gastric cancer cells." British Journal of Cancer 121, no. 10 (2019): 846–56. http://dx.doi.org/10.1038/s41416-019-0600-9.

Full text
Abstract:
Abstract Background Tumours consist of heterogeneous cancer cells and are likely to contain drug-tolerant cell subpopulations, causing early relapse. However, treatment strategies to eliminate these cells have not been established. Methods We established gastric cancer patient-derived cells (PDCs) to examine the contribution of CD44 splicing variant 9 (CD44v9)-positive cells in gastric cancer drug tolerance. We performed gene expression signature-based in silico screening using JFCR_LinCAGE, our anticancer compound gene expression database and subsequent validation in BALB/c-nu/nu mouse xenogr
APA, Harvard, Vancouver, ISO, and other styles
46

Jamil, Nuzhat, Muhammad Yasir, and Ambreen Ahmed. "Heavy Metal Resistant PGPR Bioinoculants as Promising Bioremediating Agents for Modulation in Plant Growth under Chromium Metal Stress." Plant Health 1, no. 1 (2022): 01–08. http://dx.doi.org/10.33687/planthealth.01.01.4533.

Full text
Abstract:
Chromium generally hinders plant growth, but bacterial inoculations by following different mechanisms can enhance tolerance against heavy metal stress in plants. Characterization and identification of the bacterial strains which have capability to improve growth of plants growing under chromium stressed environment by reducing uptake of metal was the main objective of this present study. For this purpose, chromium tolerant bacterial strains were isolated from tannery effluents from industrial area Kasur, Pakistan and finally three competent bacterial isolates showing minimum inhibitory concent
APA, Harvard, Vancouver, ISO, and other styles
47

Chen, Hongxu, Shensi Shen, Sara Faouzi, et al. "Abstract 3268: Biomarkers of drug-tolerant persistent melanoma cells in human, correlation with tumor microenvironment and response to treatment." Cancer Research 83, no. 7_Supplement (2023): 3268. http://dx.doi.org/10.1158/1538-7445.am2023-3268.

Full text
Abstract:
Abstract Introduction: Drug tolerant cancer persister cells can be silent for years but constitute a reservoir of genetic resistance and can eventually result in tumor relapse. We showed that targeted therapy (TT)-tolerant BRAFV600 melanoma persister cells (MPC) have a reduced global mRNA translation activity but an increased translation efficiency of a subset of mRNAs encoding proteins involved in transcription, chromatin remodeling and epigenetic changes. Here, we identify protein markers of MPC in patient biopsies treated either with TT or with immune checkpoint inhibitors (ICI). Since pers
APA, Harvard, Vancouver, ISO, and other styles
48

IKHIDE, Evbonmai Charles, Joshua OLU, Hajara Oyiza Yusuf, Zainab BELLO, and Millicent Chekwube ONYEKWULE. "Antimicrobial effect of Sodium hypochlorite and Aloe vera (Aloe barbadensis miller) under varying conditions on coliform isolated from Oil polluted water from Apapa, Lagos." Environmental Studies Journal 1, no. 1 (2022): 36–45. http://dx.doi.org/10.36108/esj/2202.10.0130.

Full text
Abstract:
This study aims at evaluating the antimicrobial effect of Aloe vera and Sodium hypochlorite under varying parameters on coliform isolated from oil polluted water. Presumptive test was carried out on the oil polluted water sample obtained from Ibafon in Apapa, Lagos, Nigeria to determine the presence of coliforms; confirmatory test was done on the positive samples to determine the coliform thermo-tolerant characteristics. A Completed test was carried out to isolate Escherichia coli O157:H7. The oil polluted water shows a coliform count of &gt;1800 cfu/100ml. Thermo-tolerant E. coli (TE), pathog
APA, Harvard, Vancouver, ISO, and other styles
49

Li, Mei Hua, Apeng Liang, Kai Wang, et al. "Abstract 5329: Development of a novel selective CDK4 inhibitor for HR+/HER2- breast cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 5329. https://doi.org/10.1158/1538-7445.am2025-5329.

Full text
Abstract:
Abstract Introduction: FDA approved CDK4/6 inhibition medicines has demonstrated significant clinical benefits in patients with HR+/HER2- breast cancer. However, the dual CDK4/6 inhibitors also present severe on-target toxicity leading to severe adverse effects (SAE) in the clinic, such as neutropenia. Clinical studies with palbociclib reported grade 3-4 neutropenia events in 60-66% of patients receiving the treatment. To dissect the cause of the clinical toxicity of CDK4/6, it has been found that CDK6, not CDK4, is directly involved in the differentiation of myeloid cell in which CDK6 express
APA, Harvard, Vancouver, ISO, and other styles
50

Georgieva, Natalia, Ivelina Nikolova, and Valentin Kosev. "Variation in allelopathic tolerance of vetch cultivars to Sorghum halepense L. (Pers.) extracts." Pesticidi i fitomedicina 33, no. 1 (2018): 65–74. http://dx.doi.org/10.2298/pif1801065g.

Full text
Abstract:
Using allelopathic tolerance of crops and cultivars is considered a promising supplement to weed control strategies. In order to evaluate the allelopathic tolerance of vetch cultivars to Sorghum halepense extracts in germination and initial growth of the crop, a multi-factorial lab experiment was carried out based on a completely randomized design with four replications. The experimental factors were nine vetch cultivars (?Liya?, ?Lorina?, ?Moldovskaya?, ?Obrazets 666?, ?Asko?, ?Violeta?, ?Viola?, ?Beta WP?, and ?Panonskaya?), two aqueous extracts (of shoot and root biomass of S. halepense) an
APA, Harvard, Vancouver, ISO, and other styles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!