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Dissertations / Theses on the topic 'Inhibitory neurotransmitters'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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1

Jordan, Russell S. (Russell Stall). "Investigation of Inhibitory Influences in Neuronal Monolayer Networks Cultured from Mouse Spinal Cord." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc500431/.

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The effects of the inhibitory neurotransmitters gammaamino butyric acid (GABA) and glycine were characterized on spontaneous activity recorded from mouse spinal cord cultures. The GABA concentration which completely inhibited burst activity was chosen as a quantifiable measure of culture drug response and was used to 1) assess interculture and intraculture variability, 2) determine the influence of culture age and initial activity on GABA responses, and 3) compare the GABA responses between networks obtained from whole spinal cord and ventral half spinal cord. Results showed that 1) no signifi

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2

Hudman, Diane. "Physiological and behavioural actions of putative inhibitory neurotransmitters in sea anemones." Thesis, University of Hull, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363274.

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3

Chung, Seo-Kyung. "Molecular and biophysical characterization of the glycinergic inhibitory system." Thesis, Swansea University, 2009. https://cronfa.swan.ac.uk/Record/cronfa42277.

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Glycinergic neurotransmission is a major inhibitory influence in the CNS and defects are associated with paroxysmal neuromotor disorder, hyperekplexia with mutations in subunits of the inhibitory glycine receptor which facilitates postsynaptic ligand-binding, ion-channels. This study investigates the human glycinergic system by; 1) Mutation analysis of glycinergic candidate genes in hyperekplexia: the DNA sequencing of GLRAl in 88 hyperekplexia patients revealed 30 sequence variants; 21 were inherited in recessive mode or part of compound heterozygosity, indicating that recessive hyperekplexia

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4

De, Faoite Andrew. "Modulation of spontaneous activity in the rabbit urethra by excitatory and inhibitory neurotransmitters." Thesis, Queen's University Belfast, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517278.

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5

Zhao, Wei. "The inhibitory mechanisms of sound processing in the dorsal cochlear nucleus of the guinea pig." Thesis, Keele University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297207.

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6

Ellenberger, Claudia. "Inhibitory and excitatory neurotransmitters in the cerebrospinal fluid of dogs with genetic and primary (idiopathic) epilepsy /." [S.l.] : [s.n.], 2002. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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7

Kurcyus, Katarzyna [Verfasser], Valentin [Akademischer Betreuer] Riedl, Helmuth [Gutachter] Adelsberger, and Markus [Gutachter] Ploner. "Using magnetic resonance spectroscopy to study neural activity: The role of inhibitory and excitatory neurotransmitters for systems-level brain dynamics / Katarzyna Kurcyus ; Gutachter: Helmuth Adelsberger, Markus Ploner ; Betreuer: Valentin Riedl." München : Universitätsbibliothek der TU München, 2017. http://d-nb.info/1172880034/34.

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8

Bavro, Vassiliy Nikolaevitch. "Structural studies of molecules involved in clustering and trafficking of inhibitory neurotransmitter receptors." Université Joseph Fourier (Grenoble), 2003. http://www.theses.fr/2003GRE10180.

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9

Li, Libin Reith Maarten E. A. "Regulation of the human dopamine transporter." Normal, Ill. Illinois State University, 2002. http://wwwlib.umi.com/cr/ilstu/fullcit?p3064534.

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Thesis (Ph. D.)--Illinois State University, 2002.<br>Title from title page screen, viewed February 3, 2006. Dissertation Committee: Maarten E.A. Reith (chair), Hou Tak Cheung, Paul A. Garris, Stephen M. Lasley, Brian J. Wilkinson. Includes bibliographical references and abstract. Also available in print.

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10

Garcia, Adrian Dante. "Neural correlates of visual perceptual learning and inhibitory neurotransmitter in humans using magnetic resonance spectroscopy." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7770/.

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The role of excitatory processes in human visual learning has been well characterised through the use of technologies such as functional magnetic resonance imaging (fMRI). However, established imaging modalities do not distinguish excitatory processes from the inhibitory ones that are also involved. Here we investigate inhibitory processes using magnetic resonance spectroscopy (MRS) and the MEGA-PRESS pulse sequence. We measure concentrations of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in different brain regions as functional markers of inhibitory potential. We then inves

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11

Mavencamp, Terri Lynn. "Design, synthesis and biological evaluation of a family of excitatory amino acid transporter 3 (EAAT3) preferring inhibitors." [Missoula, Mont.] : The University of Montana, 2008. http://etd.lib.umt.edu/theses/available/etd-03212009-152926/unrestricted/Mavencamp_umt_0136D_10009.pdf.

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12

Rosner, Elisabeth [Verfasser], and Boris [Akademischer Betreuer] Chagnaud. "Inhibitory and modulatory neurotransmitter in the brain of socially communicating fishes / Elisabeth Rosner ; Betreuer: Boris Chagnaud." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1208150448/34.

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13

Kühn, Claudia [Verfasser]. "Localization of excitatory and inhibitory neurotransmitter receptors in an identified motoneuron of the Drosophila Flight System / Claudia Kühn." Berlin : Freie Universität Berlin, 2012. http://d-nb.info/1029793298/34.

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14

Ares, Jeffrey Joseph. "Part 1: Synthesis of irreversible inhibitors of Aldose reductase with subsequent development of carbon-13 NMR protein probe. Part 2: Synthesis of selenium analogs of dopamine as potential dopamine receptor agonists /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487268021748119.

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15

Quérée, Philip. "Feedback control in the central 5-HT system : evidence for a role of 5-HT₂c receptors." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670061.

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16

Mesfioui, Abdelhalem ben Mehdi. "Contribution à l'étude des mécanismes mis en jeu dans les flux transmembranaires de neurotransmetteurs : Action de l'amphétamine, de la phényléthylamine et de la tranylcypromine sur la libération des catécholamines et l'activité des composantes du système de l'adénosine triphosphatase." Nancy 1, 1988. http://www.theses.fr/1988NAN10187.

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De façon classique, la libération des neurotransmetteurs au niveau synaptique implique un mécanisme d'exocytose nécessitant la médiation d'ions calcium. Cette libération peut se produire en absence de calcium extracellulaire ; elle dépend alors du gradient sodique trasmembranaire et sera modulée par tout paramètre affectant l'amplitude de ce gradient notamment l'activité (Na+,K+)-ATPasique, expression enzymatique de la pompe à sodium. Nous avons entrepris une analyse de ce mécanisme par une expérimentation in vivo et in vitro portant sur l'action de l'amphétamine et de composés apparentés (phé

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17

Pigeon, Dominique. "Etude des enzymes de synthèse des catécholamines et phosphorylation de la tyrosine hydroxylase de phéochromocytome de rat." Paris 6, 1986. http://www.theses.fr/1986PA066168.

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La structure et le régulation des enzymes de synthèse des catécholamines ont été étudiées dans le phéochromocytome de rat. Nous avons mis au point un protocole permettant la séparation des trois premiers enzymes de la voie de synthèse. Ceci a permis de purifier partiellement la dopamine beta -hydroxylase et de mettre en évidence son inhibiteur endogène, qui a été décrit pour la première fois. Nous avons montré qu'une activité protéine kinase était copurifiée avec la tyrosine hydroxylase, qu'elle phosphoryle. Cette activité a été caractérisé et la séquence primaire du site de phosphorylation a

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18

Miksa, Michael. "N-Methyl-D-Aspartat-Antagonisten induzierten apoptotische Zelluntergänge im Gehirn junger Ratten." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2004. http://dx.doi.org/10.18452/15030.

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Der wichtigste exzitatorische Neurotransmitter Glutamat spielt eine grosse Rolle in der Gehirnentwicklung, wie neuronale Migration und Synaptogenese. Ob glutamaterge Stimulation für das Überleben entwickelnder Neuronen notwendig ist, war bislang jedoch unbekannt. Um zu untersuchen, ob eine Hemmung von Glutamatrezeptoren im unreifen Gehirn zu Neurodegeneration führt, wurden Ratten im Alter von 1 bis 31 Tagen für 24 Stunden mit dem N-Methyl-D-Aspartat-(NMDA) Glutamatrezeptorantagonisten Dizocilpin (MK801) behandelt. Die Dichte neuronaler Degeneration wurde mikroskopisch in Kupfer-Silber- und TUN

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19

Joseph, Deepthi. "Structural, mechanistic and pharmacological studies of inhibitory neurotransmitter transporters." Thesis, 2021. https://etd.iisc.ac.in/handle/2005/5770.

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Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system (CNS). The synaptic levels of GABA are controlled by the activity of GABA transporters (GATs) present in the presynaptic and glial membranes. Impaired GABAergic signaling leads to hypersynchronous excitatory discharges that can result in epileptic conditions. Other than the roles in CNS, GABA plays an important role in hormone homeostasis, regulation of muscle tone, neural development and inflammation. GAT1, GAT2 and GAT3 are the most studied isoforms of GATs and 75% of the GABA reuptake is pe

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20

Canal, Clinton Ernest. "Protein synthesis inhibitors impair memory by disrupting release of neurotransmitters important for memory modulation /." 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3250216.

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Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2006.<br>Source: Dissertation Abstracts International, Volume: 68-02, Section: B, page: 0791. Adviser: Paul E. Gold. Includes bibliographical references (leaves 101-134) Available on microfilm from Pro Quest Information and Learning.

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21

Juniku, Rajan B. "Part I: Synthesis and evaluation of synosutine as an inhibitor of serotonin, norepinephrine, and dopamine transporters Part II: Asymmetric approach to the tetracyclic core of neomangicol A." Thesis, 2012. http://hdl.handle.net/1957/30439.

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Part I: Racemic and asymmetric syntheses of a new substance with prospective antidepressant properties were achieved. In vitro assays with synthetic racemates (±)-25 and (±)-26 suggested that the former is a relatively selective inhibitor of serotonin transporter whereas the latter is a more balanced inhibitor of both serotonin and norepinephrine transporter. An initial approach to enantiomers of 25 and 26 via resolution of carboxylic acids 21 and 22 was unsuccessful but a de novo strategy which introduced asymmetry by means of Charette enantioselective cyclopropanation led to (+)-25, (-)-25,

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