Relevant bibliographies by topics / Inhibitory proteinkináz

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Academic literature on the topic 'Inhibitory proteinkináz'

Author: Grafiati
Published: 4 June 2021
Last updated: 12 February 2022

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Dissertations / Theses on the topic "Inhibitory proteinkináz"

1

Janoušková, Adéla. "Studium vlivu vybraných inhibitorů proteinkináz na lékovou rezistenci zprostředkovanou cytochromy P450." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-397863.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Adéla Janoušková Supervisor: RNDr. Jakub Hofman, Ph.D. Title of diploma thesis: Study on impact of selected protein kinase inhibitors on drug resistance mediated by cytochromes P450 Pharmacokinetic drug resistance often leads to failure of an anticancer therapy. One of the mechanisms is increased efflux of drugs from tumour cells, whereas some studies suggest that increased drug conversion to an inactive metabolite might be another contributing mechanism. The aim of this work was to define
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2

Vejrychová, Kateřina. "Syntéza a biologické hodnocení purinových inhibitorů fosfatidylinositol-3-kinas a příbuzných proteinkinas II." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-356210.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Student: Kateřina Vejrychová Supervizor: Assoc. Prof. RNDr. Veronika Opletalová, Ph.D. Consultant: Mgr. Martin Andrš Title of diploma thesis: Synthesis and biological evaluation of purine inhibitors of phosphatidylinositol-3-kinases and related protein kinases II Cancer is a serious disease with an uncertain prognosis and difficult treatment. Nowadays, cancer is one of the most common causes of death worldwide. Options of therapies are evolving every year; nevertheless, we still do
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3

Poledníková, Michaela. "Syntéza a biologické hodnocení purinových inhibitorů fosfatidylinositol-3-kinas a příbuzných proteinkinas I." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-356217.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Student: Michaela Poledníková Supervisor: Assoc. Prof. RNDr. Veronika Opletalová, Ph.D. Consultant: Mgr. Martin Andrš Title of diploma thesis: Synthesis and biological evaluation of purine inhibitors of phosphatidylinositol 3-kinases and related protein kinases I. Cancer is a group of diseases characterized by the uncontrolled, abnormal growth of cells. Anticancer chemotherapy is one of the basic methods for treatment, but its mechanism of action is not specific and targets rapidly
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4

Kráčmarová, Jana. "Role MAPK v regulaci cytoplazmatické polyadenylace během meiotického zrání savčích oocytů." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-355662.

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Mammalian oocytes undergoing meiotic maturation are transcriptionally silent and gene expression is therefore regulated at the level of translation. One of the well established mechanisms employed in translational regulation of maternal mRNAs in oocytes is cytoplasmic polyadenylation. This process is generally controlled by phosphorylation and activation of cytoplasmic polyadenylation element binding protein (CPEB). The aim of this thesis is to determine the role of mitogen-activated protein kinase (MAPK) in regulation of CPEB-mediated cytoplasmic polyadenylation in maturing mouse and porcine
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5

Berehovska, Olena. "Vliv proteinu HBx viru hepatitidy B na aktivaci MEK1/2-ERK signalizace a inhibici IFN typu I v hepatocelulární linii Huh7." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-404204.

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Hepatitis B virus (HBV) infection is one of the major causes of chronic and cancerous liver disease. Elimination of HBV from chronically infected patients by recombinant interferon α (IFNα) monotherapy shows that the mechanisms of the innate immunity play an important role in suppressing viral infection. However, the mechanisms of recognition of the HBV genome and its escape from the mechanisms of natural immunity are still little known. One of the principal factors enabling the virus to escape from cellular restriction mechanisms is the HBx viral protein. HBx is a 154 amino acid pleiotropic m
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