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Journal articles on the topic 'Injection Induced Pain'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Bailey, Craig R. "Propofol-Induced Injection Pain." Survey of Anesthesiology 49, no. 3 (2005): 155–56. http://dx.doi.org/10.1097/01.sa.0000165246.53116.5c.

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Kim, Hee Kee, Yan Ping Zhang, Young Seob Gwak, and Salahadin Abdi. "Phenyl N -tert-butylnitrone, a Free Radical Scavenger, Reduces Mechanical Allodynia in Chemotherapy-induced Neuropathic Pain in Rats." Anesthesiology 112, no. 2 (2010): 432–39. http://dx.doi.org/10.1097/aln.0b013e3181ca31bd.

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Background Paclitaxel is a widely used chemotherapeutic drug for breast and ovarian cancer. Unfortunately, it induces neuropathic pain, which is a dose-limiting side effect. Free radicals have been implicated in many neurodegenerative diseases. The current study tests the hypothesis that a free radical scavenger plays an important role in reducing chemotherapy-induced neuropathic pain. Methods Neuropathic pain was induced by intraperitoneal injection of paclitaxel (2 mg/kg) on four alternate days (days 0, 2, 4, and 6) in male Sprague-Dawley rats. Phenyl N-tert-butylnitrone (PBN), a free radica

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CHOHEDR, ABDUL HAMEED, M. MASJEDI, and M. SEYEDI. "PROPOFOL INDUCED PAIN;." Professional Medical Journal 15, no. 02 (2008): 205–10. http://dx.doi.org/10.29309/tpmj/2008.15.02.2809.

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Introduction: Propofol causes pain on injection in 28% - 90% ofpatients. A number of techniques have been tried for minimizing propofol-induced pain with variable results.Objectives:To compare the use of premixed lidocaine-propofol with metoclopramide pretreatment for the reduction of pain duringinjection of propofol in adult patients. Design: A prospective, double blind, randomized, placebo-controlled study.Setting: Shiraz University Hospital, Department of Anesthesiology, Shiraz, Iran. Period: From Jan 2007 to Dec 2007.Materials & Methods: 202 subjects (ASA I-II) scheduled for elective o

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Qu, Ning, René Lindstrøm, Rogerio Pessoto Hirata, and Thomas Graven-Nielsen. "Experimental neck muscle pain increase pressure pain threshold over cervical facet joints." Scandinavian Journal of Pain 16, no. 1 (2017): 182–83. http://dx.doi.org/10.1016/j.sjpain.2017.04.052.

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AbstractAimsEvaluate pressure pain threshold (PPT) over cervical facet joints before and after injection of experimental pain in the trapezius and multifidus muscles.MethodsFourteen healthy subjects (6 women) received randomized ultrasound-guided injections of hypertonic saline (5.8%), in the right multifidus muscle medial to C4/C5 facet joint and in the right trapezius muscle at the midpoint between C7 spinous process and acromion. The saline-induced pain intensity was assessed on a VAS scale. Before and during saline-induced pain PPTs were assessed by pressure algometry bilaterally over C2/C

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Zhang, Kaibo, Jiang Yu, Jian Li, and Weili Fu. "The Combined Intraosseous Administration of Orthobiologics Outperformed Isolated Intra-articular Injections in Alleviating Pain and Cartilage Degeneration in a Rat Model of MIA-Induced Knee Osteoarthritis." American Journal of Sports Medicine 52, no. 1 (2024): 140–54. http://dx.doi.org/10.1177/03635465231212668.

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Background: Intra-articular (IA) platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) injections have shown efficacy and safety in treating osteoarthritis (OA). However, the effectiveness and mechanisms of combined intraosseous (IO) administration of these orthobiologics have yet to be explored. Purpose/Hypothesis: The purpose of this study was to evaluate the effect on pain, cartilage, synovium/infrapatellar fat pad (IFP), and subchondral bone in rat knee OA, comparing isolated IA with combined IA and IO (IA+IO) injections of PRP or BMAC. It was hypothesized that combined in

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Feda, May, Najlaa Al Amoudi, Aly Sharaf, et al. "A Comparative Study of Children's Pain Reactions and Perceptions to AMSA Injection using CCLAD versus Traditional Injections." Journal of Clinical Pediatric Dentistry 34, no. 3 (2010): 217–22. http://dx.doi.org/10.17796/jcpd.34.3.3201l74255560520.

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Pain control is an important part of dentistry, particularly in pediatric dentistry. Recently, a computer-controlled local anesthetic delivery system (CCLAD) has been developed to reduce pain related to the local anesthetic injection. In conjunction with this technology, a new approach to the anterior and middle superior alveolar nerves (AMSA) has been induced. Studies evaluating the CCLAD in pediatric dentistry showed variable results regarding its use in pediatric dentistry. Further evaluation of this technique is needed to provide sound scientific evidence on the use of the CCLAD at this sp

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Jensen, Kai, and Michael Norup. "Experimental Pain in Human Temporal Muscle Induced by Hypertonic Saline, Potassium and Acidity." Cephalalgia 12, no. 2 (1992): 101–6. http://dx.doi.org/10.1046/j.1468-2982.1992.1202101.x.

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The study was aimed at developing a reference model for experimental pain and tenderness in the human temporal muscle by the local injection of hypertonic saline, potassium chloride and acidic phosphate buffer, using isotonic saline as control. The design was randomized and double-blind. Twenty healthy subjects had 0.2 ml test solution injected into one temporal muscle and saline into the other. Following each injection, pain was rated on a 10-point ordinal scale and pressure-pain thresholds were measured every minute for 10 min by a pressure algometer. Hypertonic saline ( n = 11) and potassiu

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Zhao, Ya-Qun. "The Analgesic Effects of Celecoxib on the Formalin-induced Short- and Long-term Inflammatory Pain." May 2017 4, no. 20;4 (2017): E575–584. http://dx.doi.org/10.36076/ppj.2017.584.

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The non-steroidal anti-inflammatory drug celecoxib has long been used for reducing pain, in spite of moderate gastrointestinal side effects. In previous studies, it has been shown that celecoxib can inhibit formalin-induced spontaneous pain and secondary hyperalgesia. Injecting formalin into a rodent’s hind paw not only induces acute pain behaviors, but also produces long-lasting hyperalgesia. Whether celecoxib can also have long-lasting effects is still unknown. Our results show that pretreatment with an intraperitoneal injection of celecoxib at one hour before formalin injection induced inhi

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Nishi, Keita, Takefumi Moriuchi, Ryohei Okamura, et al. "Mirror Therapy Reduces Pain and Preserves Corticomotor Excitability in Human Experimental Skeletal Muscle Pain." Brain Sciences 14, no. 3 (2024): 206. http://dx.doi.org/10.3390/brainsci14030206.

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Approaches to preserve corticomotor excitability (CE) are attracting interest as a treatment for pain-induced changes in neural plasticity. We determined the effects of mirror therapy (MT) on skeletal muscle pain. Fifteen healthy adults who received hypertonic saline injections (5.8% NaCl, 0.2 mL) into the first dorsal interosseous (FDI) muscle of the right hand to induce experimental skeletal muscle pain were assigned to either the “MT and injection” or “injection only” group. Post-injection, the “MT and injection” group observed their left index finger abducting and adducting for 4 min, crea

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Ford, Brendon, Milton Cohen, Mark Halaki, Joanna Diong, and Karen A. Ginn. "Experimental shoulder pain models do not validly replicate the clinical experience of shoulder pain." Scandinavian Journal of Pain 20, no. 1 (2019): 167–74. http://dx.doi.org/10.1515/sjpain-2019-0055.

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AbstractBackground and aimsPeople with shoulder pain often present with abnormal shoulder muscle function. It is not known whether shoulder pain causes or is the result of muscle dysfunction. If pain leads to muscle dysfunction, therapeutic interventions that produce shoulder pain may be contraindicated. Experimentally induced nociception can be used to investigate a causal relationship between shoulder pain and muscle dysfunction. However, the validity of current experimental shoulder pain protocols has not been established. The aim of this study was to determine whether current experimental

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Ishida, Takashi, Natsuko Watanabe, Satoshi Tanaka, and Mikito Kawamata. "Skin cooling and topical application of menthol can reduce propofol injection-induced pain, a randomized trial." Medicine 104, no. 24 (2025): e42809. https://doi.org/10.1097/md.0000000000042809.

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Background: Skin cooling has an analgesic effect on propofol injection-induced pain. We evaluated the analgesic effectiveness of topical menthol application and skin cooling for reducing propofol injection-induced pain. Methods: Patients (n = 120) were randomized to a cooling group, a room temperature group (non-cooling group), a menthol group, and a solvent group. In the cooling group, a cooling gel pad (7°C) was applied to the forearm. In the non-cooling group, a gel pad (25°C) was used. In the menthol group, 30% menthol was applied to the forearm. In the solvent group, a solvent was applied

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Sørensen, Line Bay, Parisa Gazerani, Kathleen A. Sluka, and Thomas Graven-Nielsen. "Repeated Injections of Low-Dose Nerve Growth Factor (NGF) in Healthy Humans Maintain Muscle Pain and Facilitate Ischemic Contraction–Evoked Pain." Pain Medicine 21, no. 12 (2020): 3488–98. http://dx.doi.org/10.1093/pm/pnaa315.

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Abstract Objective Nerve growth factor (NGF) is essential for generating and potentiating pain responses. This double-blinded crossover study assessed NGF-evoked pain in healthy humans after repeated NGF injections in the tibialis anterior (TA) muscle compared with control injections of isotonic saline. Subjects Twenty healthy subjects participated in two experimental phases; each consisted of seven sessions over 21 days. Methods At day 0, day 2, and day 4, a low-dose NGF (1 µg) was injected. Data on daily self-reported muscle pain (using a Likert scale) were collected. Data on pressure pain t

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Xue, Yan, Sailin Dai, Jiexian Liang, and Wenjin Ji. "Effect of reactive oxygen species of the psoas major muscle in complete Freund’s adjuvant-induced inflammatory pain in rats." Molecular Pain 16 (January 2020): 174480692092924. http://dx.doi.org/10.1177/1744806920929246.

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Lower limb pain is a common clinical disease that affects millions of people worldwide. It is found in previous studies that reactive oxygen species is closely related to neuropathic, cancer, chemotherapy, and inflammatory pain, which can be relieved by reactive oxygen species scavengers. Furthermore, acupuncture or electroacupuncture on the psoas major muscle has a great effect on adjuvant-induced arthritis and lower back pain. In our study, we investigated the function of reactive oxygen species scavengers locally injecting into the ipsilateral psoas major muscle on complete Freund’s adjuvan

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Iwashita, Narihito, and Natsu Koyama. "Pain and axon reflex induced by subcutaneous injection of glutamate." PAIN RESEARCH 19, no. 3 (2004): 91–97. http://dx.doi.org/10.11154/pain.19.91.

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Dehghani, Rouhullah, Tahereh Khamechian, Azar Dehghani, Mojtaba Limoee, Mazdak Limoee, and Hooshyar Hossini. "Investigation of the Behavioral and Clinical Effects of Black Scorpion Venom in Albino Rats." Iranian Journal of Toxicology 14, no. 3 (2020): 165–70. http://dx.doi.org/10.32598/ijt.14.3.684.1.

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Background: Aggressive behaviors in human and experimental animals have previously been described following induced pain. Aggression in rodents has been attributed to genetic and environmental factors, such as pain. A major complication of scorpion envenomation is severe pain in animals and humans. Considering that envenomation by black scorpion (Androctonus crassicauda) induces severe pain, the present study was conducted to investigate the effects of the venom on inducing aggressive behaviors in rats due to the pain from stinging. Methods: Rats in the control (n=20) and experimental groups (

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Richebé, Philippe, Cyril Rivat, Jean-Paul Laulin, Pierre Maurette, and Guy Simonnet. "Ketamine Improves the Management of Exaggerated Postoperative Pain Observed in Perioperative Fentanyl-treated Rats." Anesthesiology 102, no. 2 (2005): 421–28. http://dx.doi.org/10.1097/00000542-200502000-00028.

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Background Although opioids are unsurpassed analgesics, experimental and clinical studies suggest that opioids activate N-methyl-d-aspartate pronociceptive systems leading to pain hypersensitivity and short-term tolerance. Because it is difficult in humans to differentiate pain from hyperalgesia during the postoperative period, the authors performed experimental studies with fentanyl using the rat incisional pain model for evaluating relations between hyperalgesia and short-term tolerance. Because N-methyl-d-aspartate receptor antagonists oppose both pain hypersensitivity and tolerance induced

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Navarro-Alvarez, Nalú, Beatriz M. M. Gonçalves, Alec R. Andrews, David H. Sachs, and Christene A. Huang. "A CFA-Induced Model of Inflammatory Skin Disease in Miniature Swine." International Journal of Inflammation 2018 (June 24, 2018): 1–8. http://dx.doi.org/10.1155/2018/6916920.

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Similarities between porcine and human skin make the pig an ideal model for preclinical studies of cutaneous inflammation and wound healing. Complete Freund’s adjuvant (CFA) has been used to induce inflammation and to study inflammatory pain in several animal models. Here, we evaluated the inflammation caused by CFA injected in different layers of skin and subcutaneous (SC) tissue in a large-animal model. The degree of inflammation was evaluated at early and late time points by visual inspection and histopathologic analysis. In addition, the side effects of CFA injections were evaluated based

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Christidis, Nikolaos, Pegah Baghernejad, Aylin Deyhim, and Hajer Jasim. "Salivary Alpha-Amylase in Experimentally-Induced Muscle Pain." Diagnostics 10, no. 9 (2020): 722. http://dx.doi.org/10.3390/diagnostics10090722.

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Salivary alpha-amylase (sAA) is a marker of psychological stress and might also be a potential marker for pain-associated stress due its non-invasive, cost-effective, and stress-free collection. The current study aimed to investigate whether the levels of sAA are influenced by experimentally induced muscle pain. In this study, 26 healthy, pain-free and age-matched participants (23.8 ± 2.6 years) were included, 13 women and 13 men. Prior to the experiment, questionnaires assessing health and anxiety were completed. Muscle pain was then induced through intramuscular injection of 0.4 mL hypertoni

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Benyamin, Ramsin. "Corticosteroid Induced Psychosis in the Pain Management Setting." December 2008 6;11, no. 12;6 (2008): 917–20. http://dx.doi.org/10.36076/ppj.2008/11/917.

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Background: Synthetic corticosteroids are commonly utilized in interventional pain management procedures. These substances have potential side-effects including psychological adverse events. Objective: We describe a case of substance-induced psychotic disorder resulting from corticosteroids administration. Design: Case Report Methods: We describe a 67-year-old male that, six months prior to being consulted at our center, received a cervical epidural, 4 level medial branch blocks, 4 trigger point injections and a tendon injection in the shoulder all including corticosteroids all in one treatmen

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Ma, Yurong, Wenwen Liu, Lingzhi Liang, et al. "Synergistic Antinociceptive Effects of Indomethacin–Pregabalin and Meloxicam–Pregabalin in Paclitaxel-Induced Neuropathic Pain." Biomedicines 10, no. 6 (2022): 1413. http://dx.doi.org/10.3390/biomedicines10061413.

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Neuropathic pain is often closely associated with nerve injury or inflammation, and the role of traditional nonsteroidal anti-inflammatory drugs as adjuvants for treating chemotherapy-induced peripheral neuropathic pain remains unclear. In this study, the potential synergistic antinociceptive effects of indomethacin–pregabalin and meloxicam–pregabalin were evaluated in paclitaxel-induced neuropathic pain and carrageenan-induced inflammatory pain in rodents. Although indomethacin and meloxicam alone only slightly relieved mechanical allodynia in the above two models, isobolographic analysis sho

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Leenaars, P. P. A. M., M. A. Koedam, P. W. Wester, V. Baumans, E. Claassen, and C. F. M. Hendriksen. "Assessment of side effects induced by injection of different adjuvant/antigen combinations in rabbits and mice." Laboratory Animals 32, no. 4 (1998): 387–406. http://dx.doi.org/10.1258/002367798780599884.

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We evaluated the side effects induced by injection of Freund's adjuvant (FA) and alternative adjuvants combined with different antigens. Rabbits and mice were injected subcutaneously, intramuscularly (rabbits) and intraperitoneally (mice) with different adjuvants (FA, Specol, RIBI, TiterMax, Montanide ISA50) in combination with several types of antigens (synthetic peptides, autoantigen, glycolipid, protein, mycoplasma or virusesl. The effects of treatment on the animals' well-being were assessed by clinical and behavioural changes (POT and LABORAS assays) and gross and histopathological change

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Lee, Seung Jae, Yeoung Su Lyu, Hyung Won Kang, et al. "Antinociception of Heterotopic Electro-Acupuncture Mediated by the Dorsolateral Funiculus." American Journal of Chinese Medicine 35, no. 02 (2007): 251–64. http://dx.doi.org/10.1142/s0192415x07004795.

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We investigated the inhibitory pathways that mediate the antinociceptive effects of heterotopic electro-acupuncture (EA) on formalin injection-induced pain in rats. EA (2 ms, 10 Hz, 3 mA) was delivered to heterotopic acupoints HT7 and PC7 for 30 min; this was followed immediately by subcutaneous injection of formalin into the left hind paw of rats. Naltrexone (10 mg/kg, i.p.), an opioid receptor antagonist, was administered to evaluate the involvement of endogenous opioids. The dorsolateral funiculus (DLF), which is a descending pathway that inhibits pain, was transected at the ipsilateral T10

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Rasmussen, Keith G., and Matthew J. Ritter. "Anesthetic-Induced Pain on Injection in Electroconvulsive Therapy." Journal of ECT 30, no. 3 (2014): 203–9. http://dx.doi.org/10.1097/yct.0000000000000088.

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Honarmand, Azim, and Mohammadreza Safavi. "Prevention of Propofol-Induced Injection Pain by Sufentanil." Clinical Drug Investigation 28, no. 1 (2008): 27–35. http://dx.doi.org/10.2165/00044011-200828010-00004.

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Liu, Xinhe, Ning Wang, Jinyan Wang, and Fei Luo. "Formalin-induced pain prolongs sub- to supra-second time estimation in rats." PeerJ 9 (March 2, 2021): e11002. http://dx.doi.org/10.7717/peerj.11002.

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Background Temporal estimation can be influenced by pain, which is a complex psychological and physiological phenomenon. However, the time range in which perception is most sensitive to pain remains unclear. Methods In the present study, we explored the effects of acute inflammatory pain on time perception in the sub- to supra-second (0.6–2.4-s) and supra-second (2–8-s) ranges in rats. Plantar formalin injection was used to induce acute inflammatory pain, and a temporal bisection task was used to measure time perception. Task test sessions were held for five consecutive days (one per day): the

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Kaur, Harpuneet, and Rashmeet Kaur. "A survey to evaluate and compare patients perception to pain, pressure and discomfort induced by types of injection techniques used for mandibular anaesthesia." International Journal of Oral Health Dentistry 8, no. 4 (2022): 284–87. http://dx.doi.org/10.18231/j.ijohd.2022.054.

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Local anaesthesia makes the patient and the dentist comfortable to do treatment with least amount of discomfort, but dental patient’s most frequent fear is of receiving local anaesthetic injections. The present study attempted to evaluate and compare patient’s perception to pain, pressure and discomfort induced by three types of injections (Infiltration, mental nerve block and inferior alveolar nerve block injection) for mandibular anaesthesia. Patients were asked to grade pain, pressure and discomfort associated with injection insertion on visual analog scale. Inferior alveolar nerve block wa

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Zhang, Zongchun, Xiaoxiao Jia, Dylan Treger, and Mizhou Hui. "Low molecular weight 35 kDa hyaluronan fragment HA35 in the treatment of bone metastasis pain: A case report." Medicine 103, no. 31 (2024): e39145. http://dx.doi.org/10.1097/md.0000000000039145.

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Rationale: Late-stage cancer patients often experience severe pain due to bone metastasis, caused by structural damage and cancer-induced inflammation. Hyaluronan, known to alleviate pain by blocking the TRVP1 calcium channel, faces limitations due to its high molecular weight. However, 35 kDa low molecular weight hyaluronan fragment (HA35) have shown promise in relieving various pains, including cancer-related pain. Nonetheless, evidence regarding their efficacy in bone metastasis pain remains scarce. Patients concerns: A 52-year-old female with a rectal malignant tumor and multiple secondary

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Nazemroaya, Behzad, and Hossein Dehghani Poudeh. "Comparison of the effect of lidocaine and its combination with melatonin and the Valsalva maneuver on etomidate induced injection pain." Anaesthesia, Pain & Intensive Care 28, no. 5 (2024): 842–49. http://dx.doi.org/10.35975/apic.v28i5.2279.

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Background & Objective: Etomidate is commonly used in anesthesia practice because of its rapid recovery time, low incidence of apnea, and lower incidence of allergic reactions; but pain upon injection is one of the unfavorable complications of this drug, which can cause both physical and mental discomfort to the patients. It is imperative to use appropriate means to lower the pain at the injection site of etomidate in patients undergoing anesthesia. We conducted this study to compare the effects of lidocaine, lidocaine and the Valsalva maneuver, with a combination of lidocaine, melatonin a

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Cunicelli, Marco, Elizabeth Piwowarski, and Tejal Raju. "A Case of Priapism After Intrathecal Morphine Injection." Pain Medicine Case Reports 5, no. 5 (2021): 273–75. http://dx.doi.org/10.36076/pmcr.2021.5.273.

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BACKGROUND: Data on the frequency of priapism after spinal injections is lacking. Priapism may occur as a rare complication following intrathecal narcotic administration. This report describes an uncommon adverse reaction to intrathecal morphine injection uniquely without concurrent local anesthetic. CASE REPORT: A 74-year-old male presented to the pain management office for a scheduled intrathecal bolus trial to monitor for response prior to permanent placement of an intrathecal pump. Following an intrathecal injection of a bolus dose of 100 mcg of morphine, the patient noted the development

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Byas-Smith, Michael G., Gary J. Bennett, Richard H. Gracely, Mitchell B. Max, Elaine Robinovitz, and Ronald Dubner. "Tourniquet Constriction Exacerbates Hyperalgesia-related Pain Induced by Intradermal Capsaicin Injection." Anesthesiology 91, no. 3 (1999): 617. http://dx.doi.org/10.1097/00000542-199909000-00010.

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Background When capsaicin is injected intradermally, hyperalgesia develops around the injection site. The authors observed that volunteers report painful sensations in the skin remote from the injection site during tourniquet constriction of the affected extremity. Methods Each volunteer received an intradermal injection of capsaicin on the volar forearm, followed by intermittent tourniquet constriction of the extremity. In some participants, the tourniquet position was rotated between different sites on the upper extremities. Laser Doppler measurements were made in the skin to measure capilla

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Sumigawa, Hisashi, Toshiaki Takahashi, Kiyoko Hirabayashi, Atsushi Isshiki, and Yasuo Watanabe. "Intrathecal injection of D-serine on formalin induced flinching response in rats." PAIN RESEARCH 19, no. 5 (2004): 197–207. http://dx.doi.org/10.11154/pain.19.197.

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Vogel, Simon, Walter Magerl, Rolf-Detlef Treede, and Andreas Schilder. "Dose-Dependent Pain and Pain Radiation after Chemical Stimulation of the Thoracolumbar Fascia and Multifidus Muscle: A Single-Blinded, Cross-Over Study Revealing a Higher Impact of Fascia Stimulation." Life 12, no. 3 (2022): 340. http://dx.doi.org/10.3390/life12030340.

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Acute low back pain can be experimentally induced by injections of hypertonic saline into deep tissues of the back, such as fascia and muscle. The current study investigated the dose-dependency of peak-pain and spatial extent of concomitant radiating pain following 50, 200 and 800 μL bolus injections of hypertonic saline (5.8%) into the thoracolumbar fascia and multifidus muscle, since data on dose-dependency is lacking in humans. Sixteen healthy subjects rated (11 female, 5 male; 23.3 ± 3.1 years, mean ± SD) intensity and spatial extent of pain. Injections into the fascia resulted in signific

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Berke, M. S., and Klas S. P. Abelson. "Buprenorphine alleviation of pain does not compromise the rat monoarthritic pain model." Scandinavian Journal of Pain 16, no. 1 (2017): 167. http://dx.doi.org/10.1016/j.sjpain.2017.04.011.

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Abstract Aims This study investigated the effects of buprenorphine treatment on pain and welfare parameters and model specific parameters in a rat model of monoarthritis to eliminate unnecessary pain from this model. Methods 32 male Sprague Dawley rats were divided into four groups: (1) A negative control without arthritis receiving no analgesia. (2) A positive monoarthritic control group receiving no analgesia, but subcutaneous saline injections twice a day. (3) A positive control with monoarthritis receiving subcutaneous carprofen once a day and saline once a day. (4) A group with monoarthri

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Bolanthakodi, Chethana, Murali Shankar Bhat, Sheba Cherian, and Raghavendra R. Huchchannavar. "Evaluation of the effect of cold normal saline as a carrier fluid in reducing propofol induced pain." Indian Journal of Clinical Anaesthesia 11, no. 4 (2024): 453–57. http://dx.doi.org/10.18231/j.ijca.2024.085.

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: Pain or discomfort during intravenous injection is a common unwanted result of Propofol, and can lead to dissatisfaction. Various methods are used to reduce ‘pain on propofol injection’ (POPI), among which mixing lignocaine with propofol is commonly used. However mixing lignocaine destabilises propofol, leading to reduced anaesthetic properties of propofol, warranting the use of other methods. Cold temperatures reduce nerve conduction velocity resulting in decreased pain signal transmission and have vasoconstrictive properties which reduce local tissue irritation, potentially minimizing pain

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Jasper, Joseph F. "Lumbar Retrodiscal Transforaminal Injection." Pain Physician 3;10, no. 5;3 (2007): 501–10. http://dx.doi.org/10.36076/ppj.2007/10/501.

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Background: Spinal injections are commonly used to treat lumbar radiculitis and back pain. Delivery of medication to specific targeted pathology is considered important for a successful therapeutic outcome. A variety of routes of injection have been devised for epidural injection of corticosteroid. Objectives: The author demonstrates a variation of the transforaminal injection technique. The radiographic spread of contrast is described using a more oblique and ventral caudad approach in the epidural space “retrodiscal.” It is suggested that the radiographic findings of this technique for disco

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Lee, Elmo Wing-Yiu, Lin Wang, Jessica Ai-Jia Liu, and Chi-Wai Cheung. "iNOS Mediates High-Fat Diet-Associated Aggravation of Complete Freund’s Adjuvant-Induced Inflammatory Pain." International Journal of Molecular Sciences 26, no. 11 (2025): 5422. https://doi.org/10.3390/ijms26115422.

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Chronic inflammatory pain (IP) remains a therapeutic challenge under the worldwide prevalence of the high-fat dietary lifestyle. This study aimed at identifying mediators of the IP augmented by short-term high-fat diet (HFD). IP was induced on C57BL/6J mice by unilateral, intra-plantar, injection of Complete Freund’s Adjuvant (CFA). Von Frey test for mechanical hyperalgesia and Hargreaves’ test for thermal hyperalgesia were performed at pre-injection baseline and post-injection 6th h. and days 1/3/5/7/10/14. Ad libitum HFD feeding started 2 weeks pre-injection in assigned groups. Body weight a

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Jung, Jaehak, Byoungryun Kim, Seong Nam Park, et al. "Impact of the Timing of Rocuronium Injection after Propofol Administration on Temporal Summation of Pain in Gynecologic Laparoscopic Surgery: A Prospective and Controlled Study." Pain Research and Management 2020 (December 9, 2020): 1–6. http://dx.doi.org/10.1155/2020/6642460.

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Purpose. Temporal summation of pain, which is defined as the perception of greater pain evoked by repetitive painful stimuli, varies among individuals. This study aimed at determining the impact of the timing of rocuronium after induction with propofol on the temporal summation of pain. Methods. One hundred patients aged 19–60 years underwent gynecologic laparoscopic surgery. Patients were randomly assigned to one of the two groups: group PRi received immediate injections of rocuronium after propofol administration and group PRd received rocuronium injections when the bispectral index score (B

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Bittencourt da Silva, L., D. Kulas, A. Karshenas, et al. "Time-course of analgesic effects of botulinum neurotoxin type A (BoNTA) on human experimental model of pain induced by injection of glutamate into temporalis muscle." Scandinavian Journal of Pain 3, no. 3 (2012): 187. http://dx.doi.org/10.1016/j.sjpain.2012.05.037.

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Abstract Background/aims Analgesic effects of BoNTA develop within few hours in animal studies and within days in human studies. We have previously shown that BoNTA can block glutamate-induced mechanical sensitization and neurogenic vasodilation in rat temporalis muscle within 3 h. The present translational study was designed to explore the time-course of analgesic effects of BoNTA on pain, sensitization and vasomotor responses in a glutamateevoked human pain model. Methods BoNTA (5U) and saline were injected (30 min interval) into the left and right temporalis muscles of 12 healthy males (24.

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Gholamhossein, Falahinia Samira Vash Maryam Farhadiyan Azadeh Mozayanimonfared Azim Azizi. "EFFECT OF SYZYGIUM GEL ON ENOXAPARIN INJECTION PAIN IN ACUTE CORONARY SYNDROME PATIENTS." Indo American Journal of Pharmaceutical Sciences 04, no. 12 (2018): 4826–32. https://doi.org/10.5281/zenodo.1134411.

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The pain resulting from enoxaparin injection is an undesirable experience that has not yet been effectively controlled in spite of the scientific advances. Therefore, this study aimed to investigate the impact of Syzygium gel on intensity of the pain induced by enoxaparin injection in patients with acute coronary syndrome (ACS). This clinical trial was performed with a crossover design in the Cardiology Department of Farshchian Hospital, Hamadan, Iran. Samples were obtained from the ACS patients through convenience method and assigned randomly into two groups of A and B. Prior to the initiatio

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Fonseca, Flavia C. S., and Igor D. G. Duarte. "5,6-, 8,9-, 11,12- and 14,15-Epoxyeicosatrienoic Acids (EETs) Induce Peripheral Receptor-Dependent Antinociception in PGE2-Induced Hyperalgesia in Mice." Pharmacology and Clinical Pharmacy Research 9, no. 2 (2024): 156–69. https://doi.org/10.15416/pcpr.v9i2.57750.

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Epoxyeicosatrienoic acids (EETs) are cytochrome P450-epoxygenase-derived metabolites of arachidonic acid that act as endogenous signaling molecules in multiple biological systems, including their controversial effects on pain, including reports of the central analgesic effect and its action in inducing pain. The aim of this study was to verify the peripheral antinociceptive effect of EETs and the effect of the selective EET receptor antagonist, 14,15-EEZE, on this antinociception. The nociceptive threshold was determined by paw pressure withdrawal, and hyperalgesia was induced by intraplantar

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Lee, Jaesung, Seohyun Chung, Minkyu Hwang, Yeongkag Kwon, Seung Hyun Han, and Sung Joong Lee. "Estrogen Mediates the Sexual Dimorphism of GT1b-Induced Central Pain Sensitization." Cells 12, no. 5 (2023): 808. http://dx.doi.org/10.3390/cells12050808.

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We have previously reported that the intrathecal (i.t.) administration of GT1b, a ganglioside, induces spinal cord microglia activation and central pain sensitization as an endogenous agonist of Toll-like receptor 2 on microglia. In this study, we investigated the sexual dimorphism of GT1b-induced central pain sensitization and the underlying mechanisms. GT1b administration induced central pain sensitization only in male but not in female mice. Spinal tissue transcriptomic comparison between male and female mice after GT1b injection suggested the putative involvement of estrogen (E2)-mediated

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Yoon, Kyung Bong. "High-Dose Daily Opioid Administration and Poor Functional Status Intensify Local Anesthetic Injection Pain in Cancer Patients." May 2013 3;16, no. 3;5 (2013): E247—E256. http://dx.doi.org/10.36076/ppj.2013/16/e247.

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Background: Evidence for opioid-induced hyperalgesia (OIH) has been shown in animal and human studies, but the clinical implications of this phenomenon remain unclear. Objectives: We examined whether cancer patients taking opioids differ in their sensitivity to a clinical pain stimulus using a local anesthetic injection compared to those not taking opioids. We also evaluated the effect of the opioid dose, duration of opioid therapy, and patients’ pain severity and functional status on this clinical pain stimulus. Study Design: Prospective observational study. Setting: University outpatient dep

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Pichler, L., W. Schramm, W. Ulrich, K. Varadi, and H. P. Schwarz. "Antinociceptive Properties of Protein C in a Model of Inflammatory Hyperalgesia in Rats." Thrombosis and Haemostasis 73, no. 02 (1995): 252–55. http://dx.doi.org/10.1055/s-0038-1653760.

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SummaryWe investigated the role of human protein C in an animal model of inflammatory hyperalgesia. Pain was induced by intraplantar injection of carrageenan (3 mg) into the hind paw of rats. The pain threshold was measured by exerting increasing amounts of pressure (in mmHg) on the paw until a struggle reaction was observed. Protein C (8-800 IU/kg) was administered intravenously immediately after carrageenan. Controls received either intraplantar injections of saline (100 µ1) instead of carrageenan or carrageenan alone. Effects on pain threshold were expressed in percent of the pretreatment v

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Zare, Fatemeh, Shahin Hassanpour, Ahmad Asghari, and Alireza Jahandideh. "Anti-nociceptive Activity of Quebracho tannin Extract on Pain Induced by Formalin and Writhing Tests in Mice." Avicenna Journal of Medical Biochemistry 9, no. 2 (2021): 59–64. http://dx.doi.org/10.34172/ajmb.2021.11.

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Background: Based on positive role of the tannins for pain relief, there is no report for possible antinociceptive activity of the Quebracho tannin. Objectives: This study aimed to determine the anti-nociceptive activity of the Quebracho tannin extract (QTE) on pain in mice. Materials and Methods: For this purpose, 340 mice were used for formalin and writhing tests each including 4 experiments with 4 sub-groups. In experiment 1, mice were injected with saline, QTE (100 mg/kg), QTE (200 mg/kg), QTE (400 mg/kg), and morphine (5 mg/kg). In the second experiment, injections included saline, QTE (4

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Cha, Myeounghoon, Kyung Hee Lee, Minjee Kwon, and Bae Hwan Lee. "Possible Therapeutic Options for Complex Regional Pain Syndrome." Biomedicines 9, no. 6 (2021): 596. http://dx.doi.org/10.3390/biomedicines9060596.

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Complex regional pain syndrome (CRPS) describes an array of painful conditions that are characterized by continuing regional pain. CRPS comprises severe and inappropriate pain in cases of complete recovery after trauma. Research on the pharmacological treatment of CRPS, however, has not been well investigated. In this study, we compared the pain relief effects of different drugs (URB597, pyrrolidine dithiocarbamate, and hydralazine) in a rat model of chronic post-ischemic pain-induced CRPS. After drug injection, CRPS-induced mechanical allodynia was significantly recovered. After three repetit

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Abdi, Salahadin. "Pentoxifylline Ameliorates Mechanical Hyperalgesia in a Rat Model of ChemotherapyInduced Neuropathic Pain." Pain Physician 4;19, no. 4;5 (2016): E589—E600. http://dx.doi.org/10.36076/ppj/2019.19.e589.

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Background: Chemotherapy-induced neuropathic pain is difficult to treat. Pentoxifylline inhibits the production of inflammatory cytokines including tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β). Objective: The aims of our study were to investigate the analgesic and preventive effects of pentoxifylline on paclitaxel-induced neuropathic pain in rats and to identify its mechanisms of action. Study Design: Controlled animal study. Methods: Neuropathic pain was induced with intraperitoneally injected paclitaxel on 4 alternate days in male Sprague-Dawley rats. Pentoxifylline was adminis

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Wu, Zong-Sheng, Hung-Jen Wang, Wei-Chia Lee, Hou Lun Luo, Tsu-Kung Lin, and Yao-Chi Chuang. "Low-Energy Shock Wave Suppresses Prostatic Pain and Inflammation by Modulating Mitochondrial Dynamics Regulators on a Carrageenan-Induced Prostatitis Model in Rats." International Journal of Molecular Sciences 24, no. 4 (2023): 3898. http://dx.doi.org/10.3390/ijms24043898.

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A low-energy shock wave (LESW) has therapeutic effects on chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS); however, its mechanism of action remains unclear. We explored the effects of LESW on the prostate and mitochondrial dynamics regulators in a rat model of carrageenan-induced prostatitis. The imbalance of mitochondrial dynamics regulators may affect the inflammatory process and molecules and contribute to CP/CPPS. Male Sprague–Dawley rats received intraprostatic 3% or 5% carrageenan injections. The 5% carrageenan group also received LESW treatment at 24 h, 7 days, and 8 days. Pa

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Cheng, Kuang-I., Hung-Chen Wang, Yi-Chia Wu, et al. "Sciatic Nerve Intrafascicular Lidocaine Injection-induced Peripheral Neuropathic Pain." Clinical Journal of Pain 32, no. 6 (2016): 513–21. http://dx.doi.org/10.1097/ajp.0000000000000293.

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Liu, Libing, Jinghui Huang, Jiao Deng, Yumei Zhou, and Jun Yu. "Suppressive Effects of Intrathecal Application of Diazepam on Visceral Pain and Hyperalgesia Induced by Intracolonic Instillation of Formalin." International Journal of Biomedical Science 2, no. 1 (2006): 64–72. http://dx.doi.org/10.59566/ijbs.2006.2064.

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Using an animal model of colonic inflammation, the effects of intrathecal (i.t.) diazepam (0.02mg/kg, 0.08mg/kg and 0.15mg/kg) on visceral pain-related behaviors and hyperalgesia associated with colonic inflammation were investigated. In this visceral pain model, acute visceral pain response was induced by intracolonic (i.c.) injection of 0.5 ml of dilute formalin (2%, 5% and 10%) in rats, and the peak pain behavioral response and hyperalgesia were evoked by i.c. 5% formalin. I.t. diazepam (0.02mg/kg, 0.08mg/kg and 0.15mg/kg) followed 10 min later by i.c. injection of 5% formalin, attenuated t

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Hajati, Alexandra, Mario Brondani, Lina Angerstig, et al. "Chocolate intake and muscle pain sensation: A randomized experimental study." PLOS ONE 18, no. 5 (2023): e0284769. http://dx.doi.org/10.1371/journal.pone.0284769.

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Background Chocolate, as a cocoa-derived product rich in flavanols, has been used for medical and anti-inflammatory purposes. Therefore, the aim of this study was to investigate if the ingestion of different percentages of cocoa products affects the experimentally induced pain caused by intramuscular hypertonic saline injections in the masseter muscle of healthy men and women. Methods This experimental randomized, double-blind, and controlled study included 15 young, healthy, and pain-free men and 15 age-matched women and involved three visits with at least a 1-week washout. Pain was induced t

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