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Journal articles on the topic 'Innervation of the skin'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Corniani, Giulia, and Hannes P. Saal. "Tactile innervation densities across the whole body." Journal of Neurophysiology 124, no. 4 (2020): 1229–40. https://doi.org/10.1152/jn.00313.2020.

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The skin is our largest sensory organ and innervated by afferent fibers carrying tactile information to the spinal cord and onto the brain. The density with which different classes of tactile afferents innervate the skin is not constant but varies considerably across different body regions. However, precise estimates of innervation density are only available for some body parts, such as the hands, and estimates of the total number of tactile afferent fibers are inconsistent and incomplete. Here we reconcile different estimates and provide plausible ranges and best estimates for the number of d

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2

Leibovich, Hodaya, Nahum Buzaglo, Shlomo Tsuriel, et al. "Abnormal Reinnervation of Denervated Areas Following Nerve Injury Facilitates Neuropathic Pain." Cells 9, no. 4 (2020): 1007. http://dx.doi.org/10.3390/cells9041007.

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An injury to peripheral nerves leads to skin denervation, which often is followed by increased pain sensitivity of the denervated areas and the development of neuropathic pain. Changes in innervation patterns during the reinnervation process of the denervated skin could contribute to the development of neuropathic pain. Here, we examined the changes in the innervation pattern during reinnervation and correlated them with the symptoms of neuropathic pain. Using a multispectral labeling technique—PainBow, which we developed, we characterized dorsal root ganglion (DRG) neurons innervating distinc

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3

Corniani, Giulia, and Hannes P. Saal. "Tactile innervation densities across the whole body." Journal of Neurophysiology 124, no. 4 (2020): 1229–40. http://dx.doi.org/10.1152/jn.00313.2020.

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The skin is our largest sensory organ and innervated by afferent fibers carrying tactile information to the spinal cord and onto the brain. The density with which different classes of tactile afferents innervate the skin is not constant but varies considerably across different body regions. However, precise estimates of innervation density are only available for some body parts, such as the hands, and estimates of the total number of tactile afferent fibers are inconsistent and incomplete. Here we reconcile different estimates and provide plausible ranges and best estimates for the number of d

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4

Ivanov, A. N., I. E. Shutrov, and I. A. Norkin. "Skin flap autografting as a method of microcirculation biostimulation in the conditions of normal and impaired innervation." Regional blood circulation and microcirculation 14, no. 3 (2015): 59–65. http://dx.doi.org/10.24884/1682-6655-2015-14-3-59-65.

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The purpose of the study. The estimation of biostimulating effect of skin flap autografting (SFA) on microcirculation in white rats in the condition of normal and impaired innervation. Materials and methods. The experiments were conducted on 5 groups of white rats: two comprison groups - the animals exposed to sciatic nerve neurorhaphy in the acute and delayed periods, and three experimental - animals with SFA in interscapular region without sciatic nerve damaging and together with acute and delayed neurorhaphy respectively. Skin microcirculation was analyzed by Lazer Doppler flowmetry (LDF).

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5

Abdelmotalab, Mohammed. "Absence of the Musculocutaneous Nerve; Two Case Reports and Literature Review." AL-Kindy College Medical Journal 20, no. 1 (2024): 71–73. http://dx.doi.org/10.47723/2zj9sm98.

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The musculocutaneous nerve is important in the upper extremity because it provides motor innervation to the musculature of the anterior arm region and sensory innervation to the skin on the lateral side of the forearm region. During the dissection of approximately 74 aged male cadaver for the 2021-2022 academic year at the Department of Anatomy, Faculty of Medicine, International University of Africa, Sudan. Considerable variation was present; the musculocutaneous nerve was observed to be absent in both upper extremities. The median nerve replaces the musculocutaneous nerve innervation’s role

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6

Hara, M., M. Toyoda, M. Yaar, et al. "Innervation of melanocytes in human skin." Journal of Experimental Medicine 184, no. 4 (1996): 1385–95. http://dx.doi.org/10.1084/jem.184.4.1385.

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Communication between the nervous system and epidermal melanocytes has been suspected on the basis of their common embryologic origin and apparent parallel involvement in several disease processes, but never proven. In this study, confocal microscopic analysis of human skin sections stained with antibodies specific for melanocytes and nerve fibers showed intraepidermal nerve endings in contact with melanocytes. This intimate contact was confirmed by electron microscopy, which further demonstrated thickening of apposing plasma membranes between melanocytes and nerve fibers, similar to synaptic

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7

English, Kathleen B., Naida Stayner, Gerald G. Krueger, and Robert P. Tuckett. "Functional Innervation of Cultured Skin Grafts." Journal of Investigative Dermatology 99, no. 2 (1992): 120–28. http://dx.doi.org/10.1111/1523-1747.ep12616765.

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8

Bjørn, Siska, Thomas Dahl Nielsen, Anne Errboe Jensen, et al. "The Anterior Branch of the Medial Femoral Cutaneous Nerve Innervates Cutaneous and Deep Surgical Incisions in Total Knee Arthroplasty." Journal of Clinical Medicine 13, no. 11 (2024): 3270. http://dx.doi.org/10.3390/jcm13113270.

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Background/Objectives: The intermediate femoral cutaneous nerve (IFCN), the saphenous nerve, and the medial femoral cutaneous nerve (MFCN) innervate the skin of the anteromedial knee region. However, it is unknown whether the MFCN has a deeper innervation. This would be relevant for total knee arthroplasty (TKA) that intersects deeper anteromedial genicular tissue layers. Primary aim: to investigate deeper innervation of the anterior and posterior MFCN branches (MFCN-A and MFCN-P). Secondary aim: to investigate MFCN innervation of the skin covering the anteromedial knee area and medial parapat

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9

Wallengren, J., A. Akesson, A. Scheja, and F. Sundler. "Occurrence and distribution of peptidergic nerve fibers in skin biopsies from patients with systemic sclerosis." Acta Dermato-Venereologica 76, no. 2 (1996): 126–28. http://dx.doi.org/10.2340/0001555576126128.

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Systemic sclerosis is characterized by vascular dysfunction. Itch is sometimes present in early stages of the disease. This prompted us to study the innervation of the skin by immunocytochemistry. Antibodies to neuropeptide Y and vasoactive intestinal peptide were used for autonomic nerves. Sensory innervation was studied using antibodies to substance P and calcitonin gene-related peptide. Protein gene product 9.5 was used as a general neuronal marker. Skin biopsies from affected (lower arm) and non-affected (upper back) sites on 10 patients with systemic sclerosis and from corresponding sites

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10

Huseynova, G. "EARLY MYELINATION OF THE MUSCULOCUTANEOUS AND SUPERFICIAL PERONEAL NERVES." Sciences of Europe, no. 164 (May 14, 2025): 41–43. https://doi.org/10.5281/zenodo.15401276.

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The musculocutaneous and superficial peroneal nerves are studied at 3-4-month fetus in the proximal and distal parts. In the proximal part both nerves consist of the fibers intended for an innervation of muscles and skin. Distal part this nerves consists of the fibers of an innervation which is consists of only skin and it’s derivate. The pieces musculocutaneous and the superficial peroneal nerves were investigated by a light and electron microscopic methods. According to a research, process of myelination of nerve fibers results from the difficult interaction of a neurolemmocyte with an

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11

Komar, T. V. "Fetal Topography of Cutaneous Nerves of Lower Leg Region." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 7, no. 2 (2022): 54–58. http://dx.doi.org/10.26693/jmbs07.02.054.

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The purpose of the study was to determine the topographic and anatomical relationships of the cutaneous nerves of the lower leg in human fetuses of 4-6 months. Materials and methods. The study was performed on 27 preparations of human fetuses of 81.0-230.0 mm parietal-coccygeal length, using the methods of macromicroscopic preparation and morphometry. Results and discussion. In most of the studied fetuses, there was a classic variant of innervation of the skin of the lower leg region, both on the right and left. In other fetuses, variability in the number and length of cutaneous nerves in the

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12

Griffin, John W., Justin C. McArthur, and Michael Polydefkis. "Assessment of cutaneous innervation by skin biopsies." Current Opinion in Neurology 14, no. 5 (2001): 655–59. http://dx.doi.org/10.1097/00019052-200110000-00016.

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13

Alves de Medeiros, M., C. M. Startin, and N. D. Jeffery. "Innervation of canine skin: an immunohistochemical study." Veterinary Record 165, no. 11 (2009): 314–18. http://dx.doi.org/10.1136/vr.165.11.314.

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14

Chang, Yang-Chyuan, Whei-Min Lin, and Sung-Tsang Hsieh. "Effects of aging on human skin innervation." NeuroReport 15, no. 1 (2004): 149–53. http://dx.doi.org/10.1097/00001756-200401190-00029.

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15

Scott, Sheryl A. "The development of skin sensory innervation patterns." Trends in Neurosciences 10, no. 11 (1987): 468–73. http://dx.doi.org/10.1016/0166-2236(87)90102-0.

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16

Hsieh, Sung-Tsang, and Whei-Min Lin. "Modulation of Keratinocyte Proliferation by Skin Innervation." Journal of Investigative Dermatology 113, no. 4 (1999): 579–86. http://dx.doi.org/10.1046/j.1523-1747.1999.00737.x.

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17

Wang, Lei, Ronald Millecchia, and Paul B. Brown. "Correlation of Peripheral Innervation Density and Dorsal Horn Map Scale." Journal of Neurophysiology 78, no. 2 (1997): 689–702. http://dx.doi.org/10.1152/jn.1997.78.2.689.

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Wang, Lei, Ronald Millecchia, and Paul B. Brown. Correlation of peripheral innervation density and dorsal horn map scale. J. Neurophysiol. 78: 689–702, 1997. Dorsal horn map scale and peripheral innervation density were compared to test a hypothesized linear relationship. In anesthetized cats, low-threshold mechanoreceptive peripheral nerve innervation fields (IFs) were measured by outlining areas of skin from which action potentials could be elicited in cutaneous nerves. The same nerves were processed histologically and used to count myelinated axons. Innervation density for each nerve was ca

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18

Berthod, François. "Tissueengineered skin and the treatment of burns: Skin doctor." Biochemist 29, no. 1 (2007): 4–6. http://dx.doi.org/10.1042/bio02901004.

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The increasing survival rates of extensively burnt patients due to the progress in intensive care has amplified the need to find alternative strategies to cover these deep burns. Tissueengineered skin models have been developed; culturing keratinocytes over a collagen gel or sponge populated with fibroblasts. Some of these models have been commercialized as biomaterials or highly sophisticated wound dressings, demonstrating the feasibility of tissueengineered skin development from bench to bedside. Investigations now aim to optimize these models to overcome some limitations encoun tered in the

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19

Sommer, Claudia, and Nurcan Üçeyler. "Small fiber pathology in fibromyalgia syndrome." PAIN Reports 10, no. 1 (2024): e1220. https://doi.org/10.1097/pr9.0000000000001220.

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Abstract About 50% of women with fibromyalgia syndrome have reduced skin innervation. This finding is consistent in patient cohorts from different regions of the world. Small fiber function may also be affected, as shown by various studies using different methods, such as quantitative sensory testing or special small fiber neurophysiology such as C-fiber microneurography. Microneurography in particular has shown increased spontaneous activity, mechanosensitivity, and enhanced activity-induced slowing in C fibers of patients with fibromyalgia. Generalized reduction of skin innervation, ie, prox

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20

Savage, M. V., G. L. Brengelmann, A. M. Buchan, and P. R. Freund. "Cystic fibrosis, vasoactive intestinal polypeptide, and active cutaneous vasodilation." Journal of Applied Physiology 69, no. 6 (1990): 2149–54. http://dx.doi.org/10.1152/jappl.1990.69.6.2149.

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The transmitter substance for the active cutaneous vasodilation that accompanies sweating during hyperthermia in humans is unknown. Hokfelt et al. (Nature Lond. 284: 515-521, 180) hypothesized that it is vasoactive intestinal polypeptide (VIP) that is cotransmitted with acetylcholine. Heinz-Erian et al. (Science Wash. DC 229: 1407-1408, 1985) reported that VIP innervation is sparse in the skin of persons with cystic fibrosis (CF). A corresponding attenuation of active vasodilation in these subjects would be evidence that VIP is involved in this effector mechanism of human thermor-regulation. I

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21

Bayramiçli, Mehmet, Ian T. Jackson, and Barry Herschman. "Innervation of skin grafts over free muscle flaps." British Journal of Plastic Surgery 53, no. 2 (2000): 130–36. http://dx.doi.org/10.1054/bjps.1999.3204.

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22

Hsieh, Sung-Tsang, Whei-Min Lin, Hou-Yu Chiang, et al. "Skin Innervation and Its Effects on the Epidermis." Journal of Biomedical Science 4, no. 5 (1997): 264–68. http://dx.doi.org/10.1159/000457011.

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23

Evdokimov, Dimitar, Philine Dinkel, Johanna Frank, Claudia Sommer, and Nurcan Üçeyler. "Characterization of dermal skin innervation in fibromyalgia syndrome." PLOS ONE 15, no. 1 (2020): e0227674. http://dx.doi.org/10.1371/journal.pone.0227674.

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24

Andre-Frei, Valerie, Christine Jeanmaire, Jean-Pierre Pennec, et al. "Re-innervation of a skin model: Functionality study." Journal of Dermatological Science 84, no. 1 (2016): e128. http://dx.doi.org/10.1016/j.jdermsci.2016.08.384.

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25

Hsieh, Sung-Tsang, Whei-Min Lin, Hou-Yu Chiang, et al. "Skin innervation and its effects on the epidermis." Journal of Biomedical Science 4, no. 5 (1997): 264–68. http://dx.doi.org/10.1007/bf02253428.

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26

Donadio, Vincenzo, Maria Nolano, Vincenzo Provitera, et al. "Skin sympathetic adrenergic innervation: An immunofluorescence confocal study." Annals of Neurology 59, no. 2 (2006): 376–81. http://dx.doi.org/10.1002/ana.20769.

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27

Manger, Paul R., Janet R. Keast, John D. Pettigrew, and Louise Troutt. "Distribution and putative function of autonomic nerve fibres in the bill skin of the platypus ( Ornithorhynchus anatinus )." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 353, no. 1372 (1998): 1159–70. http://dx.doi.org/10.1098/rstb.1998.0273.

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The electroreceptors located in the bill skin of the platypus are modified secretory glands. The electroreceptive nerve terminals form bare endings in close proximity to the duct of these glands. In this study, we describe the autonomic innervation of the glands and a separate specialized autonomic innervation of the epidermal portion of the glandular duct. A range of immunohistochemical labels showed that the gland cells of the electroreceptors have a non–noradrenergic (putative parasympathetic) innervation. Phalloidin labelling revealed a ‘phincter’ of epidermal luminal cells that labelled s

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28

Schmelz, M., R. Schmidt, A. Bickel, H. E. Torebjörk, and H. O. Handwerker. "Innervation Territories of Single Sympathetic C Fibers in Human Skin." Journal of Neurophysiology 79, no. 4 (1998): 1653–60. http://dx.doi.org/10.1152/jn.1998.79.4.1653.

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Schmelz, M., R. Schmidt, A. Bickel, H. E. Torebjörk, and H. O. Handwerker. Innervation territories of single sympathetic C fibers in human skin. J. Neurophysiol. 79: 1653–1660, 1998. Microneurography techniques were used to record action potentials from unmyelinated nerve fibers (C fibers) in the cutaneous fascicles of the peroneal nerve in healthy volunteers. C units were identified by their long latency responses to electrical stimulation of their terminals in the skin. Their responsiveness to mechanical or heat stimuli applied to the skin or to sympathetic reflex provocation tests was deter

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29

Bikbova, Guzel, Toshiyuki Oshitari, Takayuki Baba, and Shuichi Yamamoto. "Neuronal Changes in the Diabetic Cornea: Perspectives for Neuroprotection." BioMed Research International 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/5140823.

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Diabetic neuropathy is associated with neurotrophic ulcerations of the skin and cornea. Decreased corneal sensitivity and impaired innervation lead to weakened epithelial wound healing predisposing patients to ocular complications such as corneal infections, stromal opacification, and surface irregularity. This review presents recent findings on impaired corneal innervation in diabetic individuals, and the findings suggest that corneal neuropathy might be an early indicator of diabetic neuropathy. Additionally, the recent findings for neuroprotective and regenerative therapy for diabetic kerat

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30

Schmidt, Roland, Martin Schmelz, Matthias Ringkamp, Hermann O. Handwerker, and H. Erik Torebjörk. "Innervation Territories of Mechanically Activated C Nociceptor Units in Human Skin." Journal of Neurophysiology 78, no. 5 (1997): 2641–48. http://dx.doi.org/10.1152/jn.1997.78.5.2641.

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Schmidt, Roland, Martin Schmelz, Matthias Ringkamp, Hermann O. Handwerker, and H. Erik Torebjörk. Innervation territories of mechanically activated C nociceptor units in human skin. J. Neurophysiol. 78: 2641–2648, 1997. Innervation territories of single mechanically activated C nociceptors in the skin of the leg and foot were explored in normal human subjects. Microneurographic recordings were obtained in the peroneal nerve from 70 mechano-heat responsive (CMH) and 7 mechano-(but not heat) responsive (CM) units. Units were identified by their constant long-latency response to intracutaneous el

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31

McCarthy, B. G., S. T. Hsieh, A. Stocks, et al. "Cutaneous innervation in sensory neuropathies: Evaluation by skin biopsy." Neurology 45, no. 10 (1995): 1848–55. http://dx.doi.org/10.1212/wnl.45.10.1848.

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32

Cruz, V. S., J. C. Cardoso, L. B. M. Araújo, P. R. Souza, M. S. B. Silva, and E. G. Araújo. "Anatomical aspects of the nerves of the leg and foot of the giant anteater (Myrmecophaga tridactyla, Linnaeus, 1758)." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 66, no. 5 (2014): 1419–26. http://dx.doi.org/10.1590/1678-6481.

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Although distal stifle joint nerve distribution has been well established in domestic animals, this approach is scarcely reported in wild animals. Therefore, the aim of this study was to describe the nerves of the leg and foot of Myrmecophaga tridactyla with emphasis on their ramification, distribution, topography and territory of innervation. For this purpose, six adult cadavers fixed and preserved in 10% formalin solution were used. The nerves of the leg and foot of the M. tridactylawere the saphenous nerve (femoral nerve branch), fibular and tibial nerves and lateral sural cutaneous nerve (

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33

Fantini, F., A. Baraldi, C. Sevignani, A. Spattini, C. Pincelli, and A. Giannetti. "Cutaneous innervation in chronic renal failure patients. An immunohistochemical study." Acta Dermato-Venereologica 72, no. 2 (1992): 102–5. http://dx.doi.org/10.2340/0001555572102105.

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Most chronic renal failure patients suffer from generalized pruritus. An involvement of cutaneous nerve terminals in the pathogenesis of uremic pruritus has been suggested. Skin specimens from 24 uremic patients and 10 healthy subjects were processed with an indirect immunofluorescence method to investigate the presence and distribution of a number of neuronal markers and neuropeptides. No difference was found between the two groups in the distribution pattern of the positive nerve fibres. However, a reduction in the total number of skin nerve terminals in the uremic patients was detected. No

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34

Albertin, Giovanna, Barbara Ravara, Helmut Kern, et al. "Trauma of Peripheral Innervation Impairs Content of Epidermal Langerhans Cells." Diagnostics 12, no. 3 (2022): 567. http://dx.doi.org/10.3390/diagnostics12030567.

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Langerhans cells represent the first immune cells that sense the entry of external molecules and microorganisms at the epithelial level in the skin. In this pilot case-study, we evaluated Langerhans cells density and progression of epidermal atrophy in permanent spinal cord injury (SCI) patients suffering with either lower motor neuron lesions (LMNSCI) or upper motor neuron lesions (UMNSCI), both submitted to surface electrical stimulation. Skin biopsies harvested from both legs were analyzed before and after 2 years of home-based Functional Electrical Stimulation for denervated degenerating m

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35

Botchkarev, Vladimir A., Stefan Eichm�ller, Olle Johansson, and Ralf Paus. "Hair cycle-dependent plasticity of skin and hair follicle innervation in normal murine skin." Journal of Comparative Neurology 386, no. 3 (1997): 379–95. http://dx.doi.org/10.1002/(sici)1096-9861(19970929)386:3<379::aid-cne4>3.0.co;2-z.

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36

Vojvodic, Aleksandra, Michael Tirant, Veronica Di Nardo, Torello Lotti, and Uwe Wollina. "Immunocompromised Districts of Skin: A Case Series and a Literature Review." Open Access Macedonian Journal of Medical Sciences 7, no. 18 (2019): 2969–75. http://dx.doi.org/10.3889/oamjms.2019.680.

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BACKGROUND: The concept of immunocompromised districts of skin has been developed by Ruocco and helps to explain certain aspects of the macromorphology of skin diseases. This concept unites the isomorphic response of Koebner and the isotopic response of Wolf. CASE REPORTS: We present different cutaneous conditions which can lead to immunocompromised districts of skin such as scars, radiodermatitis, lymphedema, disturbed innervation or mechanical friction etc. Typical and rarer skin disorders associated with them are discussed and illustrated by their observations. CONCLUSION: At th

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37

Hryhorieva, Pavlina V., Тatiana V. Khmara, Аlina О. Palamar, Тetyana B. Sykyrytska, and Maryna Yu Leka. "ANATOMICAL VARIABILITY OF CUTANEOUS NERVES OF ANTERIOR FEMORAL REGION IN HUMAN FETUSES." Wiadomości Lekarskie 74, no. 2 (2021): 207–12. http://dx.doi.org/10.36740/wlek202102106.

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The aim: Is to find out the features of innervation of the skin of the anterior femoral region and the fascia lata during the fetal period of human development. Materials and methods: The study was carried out on 64 preparations of the lower extremities of human fetuses of 4-10 months using macromicroscopic preparation and morphometry. Macropreparations of the skin nerves of the lower extremities of different age fetuses with anatomical variants were subject to photo documentation. Results: The features of cutaneous nerve fetal topography of the anterior femoral region and the broad fascia of

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38

Saad El-Dien, Heba M., Mahmoud Rezk Abdelwahed Hussein, and Mahmoud El-Oteify. "Sensory Innervation of the Female Human Umbilical Skin: Morphological Studies." Ultrastructural Pathology 37, no. 1 (2011): 62–69. http://dx.doi.org/10.3109/01913123.2011.553351.

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39

Halata, Zdenek. "Sensory Innervation of the Hairy Skin (Light- and Electronmicroscopic Study)." Journal of Investigative Dermatology 101, s1 (1993): 75S—81S. http://dx.doi.org/10.1111/1523-1747.ep12362877.

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40

Schmidt, R. "Innervation territories of mechanoresponsive C nociceptor units in human skin." Electroencephalography and Clinical Neurophysiology 103, no. 1 (1997): 180. http://dx.doi.org/10.1016/s0013-4694(97)88849-2.

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41

Schmidt, R., M. Schmelz, C. Weidner, H. O. Handwerker, and H. E. Torebjörk. "Innervation Territories of Mechano-Insensitive C Nociceptors in Human Skin." Journal of Neurophysiology 88, no. 4 (2002): 1859–66. http://dx.doi.org/10.1152/jn.2002.88.4.1859.

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Microneurographic recordings were obtained in the peroneal nerve from 20 mechano-insensitive units (CMi) and six mechano-heat responsive C units (CMH) in healthy human subjects. Their innervation territories in the skin of the leg or foot were assessed by transcutaneous electrical stimulation with a pointed probe at intensities of 10 to 100 mA (0.2 ms) and, when applicable, by mechanical von Frey hair stimulation. Electro-receptive fields (eRFs) of CMH units had a median area of 1.95 cm2 when mapped with 10 mA that coincided approximately with mechano-receptive fields (mRFs) as mapped with a 7

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42

Maklad, Adel, Jodi R. Nicolai, Kyle J. Bichsel, et al. "The EGFR Is Required for Proper Innervation to the Skin." Journal of Investigative Dermatology 129, no. 3 (2009): 690–98. http://dx.doi.org/10.1038/jid.2008.281.

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43

Cahoon-Metzger, Sharon M., Guoying Wang, and Sheryl A. Scott. "Contribution of BDNF-Mediated Inhibition in Patterning Avian Skin Innervation." Developmental Biology 232, no. 1 (2001): 246–54. http://dx.doi.org/10.1006/dbio.2001.0172.

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44

Halata, Zdenek. "Sensory innervation of the hairy skin (light-and electronmicroscopic study)." Journal of Investigative Dermatology 101, no. 1 (1993): S75—S81. http://dx.doi.org/10.1016/0022-202x(93)90505-c.

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45

Shavit-Stein, Efrat, Shany Guly Gofrit, Alexandra Gayster, et al. "Treatment of Diabetic Neuropathy with A Novel PAR1-Targeting Molecule." Biomolecules 10, no. 11 (2020): 1552. http://dx.doi.org/10.3390/biom10111552.

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Diabetic peripheral neuropathy (DPN) is a disabling common complication of diabetes mellitus (DM). Thrombin, a coagulation factor, is increased in DM and affects nerve function via its G-protein coupled protease activated receptor 1 (PAR1). Methods: A novel PAR1 modulator (PARIN5) was designed based on the thrombin PAR1 recognition site. Coagulation, motor and sensory function and small fiber loss were evaluated by employing the murine streptozotocin diabetes model. Results: PARIN5 showed a safe coagulation profile and showed no significant effect on weight or glucose levels. Diabetic mice spe

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46

Ebendal, T., and H. Persson. "Detection of nerve growth factor mRNA in the developing chicken embryo." Development 102, no. 1 (1988): 101–6. http://dx.doi.org/10.1242/dev.102.1.101.

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Nerve growth factor (beta NGF) is a protein supporting sympathetic and sensory innervation in the peripheral tissues as well as cholinergic innervation in the brain. A DNA probe derived from a genomic clone coding for chicken NGF was used to study NGF mRNA levels during development. NGF mRNA was detected in the chicken embryo as early as day 3.5 of incubation. The level of NGF mRNA in total embryo increased four-fold until day 8, remained high until day 12, and subsequently decreased. No corresponding peak in NGF mRNA expression was found in heart and brain measured separately. Instead these o

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Giampietri, Claudia, Elisa Pizzichini, Francesca Somma, et al. "Roles of Peripheral Nerves in Tumor Initiation and Progression." International Journal of Molecular Sciences 26, no. 15 (2025): 7064. https://doi.org/10.3390/ijms26157064.

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In recent years, a long list of relevant studies has highlighted the engagement of the nervous system in the fine-tuning of tumor development and progression. Several authors have shown that different types of nerve fibres (sympathetic, parasympathetic/vagal or somatosensory fibres) may contribute to tumor innervation affecting cancer initiation, progression and metastasis. A large presence of nerve fibres is frequently observed in tumors with respect to the corresponding healthy tissues. In this regard, it is worth noting that in some cases a reduced innervation may associate with slow tumor

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Dahlke, Erin, and Christian A. Murray. "Facial Nerve Danger Zone in Dermatologic Surgery: Temporal Branch." Journal of Cutaneous Medicine and Surgery 15, no. 2 (2011): 84–86. http://dx.doi.org/10.2310/7750.2011.10064.

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Background: The principal function of cranial nerve 7 (CN VII), the facial nerve, is to provide motor innervation to the muscles of facial expression. The temporal branch of the facial nerve primarily innervates the frontalis muscle, which raises the eyebrow. Objective: To present a case that illustrates the importance of facial nerve anatomy to skin surgery practice. Conclusion: The relevant surgical anatomy of the temporal branch is reviewed, as well as clinical practice points around nerve damage in skin surgery.

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Golderman, Valery, Shani Berkowitz, Shani Guly Gofrit, et al. "Thrombin Activity in Rodent and Human Skin: Modified by Inflammation and Correlates with Innervation." Biomedicines 10, no. 6 (2022): 1461. http://dx.doi.org/10.3390/biomedicines10061461.

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Thrombin is present in peripheral nerves and is involved in the pathogenesis of neuropathy. We evaluated thrombin activity in skin punch biopsies taken from the paws of male mice and rats and from the legs of patients with suspected small-fiber neuropathy (SFN). In mice, inflammation was induced focally by subcutaneous adjuvant injection to one paw and systemically by intraperitoneal lipopolysaccharides (LPS) administration. One day following injection, thrombin activity increased in the skin of the injected compared with the contralateral and non-injected control paws (p = 0.0009). One week f

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Leurcharusmee, Prangmalee, Naraporn Maikong, Perada Kantakam, Pagorn Navic, Pasuk Mahakkanukrauh, and De Q. Tran. "Innervation of the clavicle: a cadaveric investigation." Regional Anesthesia & Pain Medicine 46, no. 12 (2021): 1076–79. http://dx.doi.org/10.1136/rapm-2021-103197.

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BackgroundThis cadaveric study investigated the innervations of the clavicle and clavicular joints (ie, sternoclavicular and acromioclavicular joints).MethodsTwenty cadavers (40 clavicles) were dissected. A skin incision was made to permit exposure of the posterior cervical triangle and infraclavicular fossa. The platysma, sternocleidomastoid, and trapezius muscles were cleaned in order to identify the supraclavicular nerves. Subsequently, the suprascapular and subclavian nerves were localized after removal of the prevertebral layer of the deep cervical fascia. In the infraclavicular region, t

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