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Salb, Katharina [Verfasser], Jens [Akademischer Betreuer] Schlossmann, and Achim [Akademischer Betreuer] Göpferich. "Funktion von IRAG für cGMP-Kinase-I-Komplexe sowie für die InsP3R-I-Phosphorylierung / Katharina Salb. Betreuer: Jens Schlossmann ; Achim Göpferich." Regensburg : Universitätsbibliothek Regensburg, 2011. http://d-nb.info/1025386124/34.
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Gouin, Olivier. "Etude du rôle de PAR-2 dans l'inflammation neurogène cutanée." Thesis, Brest, 2017. http://www.theses.fr/2017BRES0030/document.
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L’inflammation neurogène cutanée (INC) est une inflammation de la peau induite par l’activation des fibres nerveuses intra-épidermiques qui secrètent des neuropeptides tels que la substance P (SP). L’INC est impliquée dans des dermatoses inflammatoires prurigineuses comme le psoriasis, la dermatite atopique (DA) et le syndrome de Netherton (SN). Un nouveau concept émerge, suggérant que les kératinocytes sont également des acteurs majeurs de l’INC. Le récepteur activé par des protéases de type 2 (PAR-2) est fortement incriminé dans l’INC associée à ces dermatoses, ce qui permet de comprendre les voies du prurit non-histaminergique. Les enjeux thérapeutiques sont de taille puisqu’il n’existe actuellement aucun traitement efficace permettant la prise en charge spécifique du prurit histamino-indépendant au cours des dermatoses prurigineuses associées à l’INC.Bien que le rôle de PAR-2 dans la sécrétion de neuropeptides à partir des neurones sensoriels soit clairement établi, son implication dans la modulation de gènes pouvant contribuer à l’entretien ou l’amplification de l’INC reste méconnue. Le rôle inflammatoire de PAR-2 a également été démontré sur des kératinocytes cultivés en monocouche via la sécrétion de cytokines par des mécanismes dépendants du Ca2+. La surexpression de PAR-2 et la perte d’expression de certains canaux calciques impliqués dans sa réponse calcique dans les kératinocytes différenciés suggèrent des mécanismes d’action de PAR-2 différents pour ceux-ci. Dans le but d’étudier le rôle pro-inflammatoire de PAR-2 au cours des dermatoses prurigineuses, nous avons analysé l’effet de son activation sur des monocultures de neurones sensoriels issus de ganglions rachidiens dorsaux (GRD) de rat et de kératinocytes humains différenciés (DhPK), en criblant l’expression de médiateurs de l’inflammation. Pour approfondir, les voies calciques de PAR-2 sous-jacente à la modulation d’expression dans les kératinocytes différenciés, des expériences d’imagerie calcique ont été réalisées et différents antagonistes ont été utilisés pour analyser les acteurs impliqués.Dans le cadre d’un partenariat avec les laboratoires dermatologiques d’Uriage, nous avons testé les effets de l’eau thermale d’Uriage sur la modulation de gènes induite par PAR-2 dans les DhPK. Nous avons également utilisé une lignée de PC12 différenciables en neurones par le NGF afin de les utiliser comme alternatives des neurones sensoriels issus des GRD de rat pour l’étude de l’INC.L’ensemble des résultats obtenus au cours du criblage des gènes modules par PAR-2 confirme le rôle pro-inflammatoire de PAR-2 dans les neurones sensoriels de rat et dans les DhPK. La découverte d’une nouvelle voie calcique de PAR-2 dans les DhPK offre de nouvelles pistes thérapeutiques pour les dermatoses prurigineuses telles que le psoriasis, la DA et le NS. Les résultats obtenus avec l’eau thermale d’Uriage peuvent présenter une perspective thérapeutique pour les patients souffrants de dermatoses prurigineuses réfractaires aux traitements conventionnels. L’utilisation d’une lignée neuronale comme lesPC12 pour l’étude de l’INC serait une alternative utile dans le développement des tests cosmétiques avec les industriels pour notre laboratoireCutaneous neurogenic inflammation (CNI) is an inflammation of the skin induced by the activation of intraepidermal nerve fibers that release neuropeptides such as substance P (SP). CNI is involved in pruritic inflammatory skin disorders such as psoriasis, atopic dermatitis (AD) and Netherton syndrome (NS). A new concept is growing, suggesting that keratinocytes could also trigger INC. The proteases activated receptor 2 (PAR-2) is strongly incriminated in CNI associated with these dermatoses, which allow to understand the histamine-independent itching pathways. The therapeutic stakes are high since there is currently no effective treatment allowing the specific management of histamine-independent pruritus during skin disorders associated with CNI.Although the role of PAR-2 in the secretion of neuropeptides from sensory neurons is clearly established, its involvement in the modulation of genes involved in the maintenance or amplification of CNI remains unknown. The inflammatory role of PAR-2 on keratinocytes has also been demonstrated through the production of cytokines in a Ca2+-dependent mechanisms. The overexpression of PAR-2 and the loss of ORAI1 expression, a calcium channel following keratinocytes differentiation suggest different signaling pathways downstream to PAR-2 activation between undifferentiated and differentiated keratinocytes.In order to study the pro-inflammatory role of PAR-2 during pruritic dermatoses, we analyzed the effect of its activation on rat primary sensory neurons from dorsal spinal ganglia (DRG) and on differentiated human primary keratinocytes (DhPK) by screening the expression of inflammatory mediators. To deepen the Ca2+ pathways underlying PAR-2-mediated inflammatory mediator modulation in DhPK, we performed Ca2+ imaging experiments and different antagonists were used to analyze the involvement of intracellular actors. In a partnership with the dermatological laboratories of Uriage, we tested the effects of Uriage thermal water on PAR-2-induced gene modulation in DhPK. We also used a PC12 cell line differentiable in neurons by the NGF in order to use them as alternatives of rat primary sensory neurons from DRG for the study of INC. We also used a PC12 cell line differentiable in neurons by the NGF use them as alternatives of rat primary sensory neurons from DRG for the study of INC.The results obtained during the screening of the PAR-2-modulated genes confirmed the proinflammatory role of PAR-2 in rat primary sensory neurons and in DhPK. The discovery of a new PAR-2-mediated Ca2+ pathway in DhPK offers new therapeutic pathways for pruritic dermatoses such as psoriasis, AD and NS. The results obtained with the thermal water of Uriage can present a therapeutic perspective for patients suffering from pruritic dermatoses refractory to conventional treatments. The use of a neuronal cell line as the PC12 for the study of INC would be an useful alternative in the development of cosmetic tests
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Kilari, Rajagopal Sharada. "Roles of inositol diphosphates in DNA repair and effects of aspirin analogues on oesophageal cancer." Thesis, University of Wolverhampton, 2014. http://hdl.handle.net/2436/346328.
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Inositol phosphates (IPs) are important signalling molecules with various biological roles in a cell. One such role it is often associated with is DNA repair. The DNA repair process following DNA insult is considered crucial for the genomic integrity and stability. Failure to perform this task will result in mutations and possibly disease. Thus, it is important that we expand our knowledge on how these repair processes occur and identify the key factors involved in its regulation. The aim of this project was to investigate whether DNA repair was mediated by inositol diphosphates (IDPs). Using a family of yeast knockout mutants with modulated levels of IPs, it was found that IDPs are crucial in repair of DNA following insult with bleomycin and 5-fluorouracil. The observed sensitivity of the mutants was thought to be due to lack of functional repair protein, UDG-like or APE-like, in the absence of essential cofactor such as IDPs. Experiments conducted revealed that the hypersensitive kcs1Δ contain both the repair proteins required to process the DNA lesions. However, extreme extraction methods were required to access these proteins, suggesting that the proteins are mislocalised and unavailable to access the damage site and perform DNA repair. GFP-tagging the proteins Ung1, Apn1 and Rad52 in kcs1Δ proved to be of little use as it failed to show exact localisation, movement and functionality status of these proteins following bleomycin insult. The enzymes accountable for the dephosphorylation of the IDPs in vivo are the diphosphoinositol polyphosphate phosphohydrolases (DIPPs). Little is known regarding the Michaelis-Menten kinetics parameters for Ddp1p/DIPPs. In this study, using improved methods for the enzymatic synthesis and electrophoretic purification of 1-InsP7, 5-InsP7 and InsP8, the DIPP family has been kinetically characterised. Each DIPP was found to ii display similar Km values for every substrate tested (range: 35-148 nM). The rank order of Kcat values (1-InsP7 > 5-InsP7 = InsP8) was identical for each enzyme, although DIPP-1 activity was observed to be 10- to 60-fold more than DIPP-2α/β and DIPP-3α/β, irrespective of the substrate. This study reveals that Ddp1, the yeast DIPP, is capable of hydrolysing not only 5-InsP7 but also 1-InsP7 and InsP8 to a single product, InsP6. The HPLC data found InsP7 accumulation to be relatively little during InsP8 breakdown by DIPPs. Such low build-up was found to be due to rapid conversion of InsP7 to InsP6. Through this study it is also clear that InsP8 prefers to dephosphorylate through 1-InsP7. In contrary, metabolically and functionally significant steady-state route of InsP8 synthesis was observed to be via 5-InsP7. Oesophageal cancer is considered as one of the deadliest cancers worldwide because of its aggressive nature and low survival rate. Epidemiologic studies have shown that low-dose daily intake of aspirin can decrease the incidence of oesophageal cancer. The data presented in this study show the effects of a number of in-house synthesized novel aspirin analogues on oesophageal cancer cell lines, squamous cell carcinoma (SSC) and adenocarcinoma (ADC). The aspirin analogues, fumaryldiaspirin (PN517) and benzoylsalicylates (PN524, PN528 and PN529), were observed to be more potent against the oesophageal cell lines than aspirin itself. Both, quantitative and qualitative apoptosis experiments conducted revealed that these compounds largely induced apoptosis, although some necrosis was evident with PN528 and PN529. Failure to recover following the treatment with these analogues emphasized that these drugs are largely cytotoxic in nature. The SSC cells (oe21) displayed increased sensitivity to the aspirin analogues compared to the ADC cell lines (flo-1 and oe33). The anticancer properties of these novel aspirin compounds appear to not involve the COX-enzymes at the tested concentrations. These initial findings support further studies into the potential of these aspirin analogues as chemotherapeutic agents against oesophageal cancer.
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Keddie, Neil S. "The synthesis and biological evaluation of d-myo-inositol 1,4,5-trisphosphate receptor ligands." Thesis, University of St Andrews, 2010. http://hdl.handle.net/10023/963.
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The intracellular second messenger InsP₃ is a vital molecule in the regulation of Ca²⁺ signalling. Ca²⁺ mediates a wide range of cellular activities from fertilisation and cell differentiation through to apoptoisis. Using X-ray crystal structure data and molecular modelling, a series of novel InsP₃ analogues were designed as selective InsP₃R-antagonists. Two novel synthetic routes have been developed for the synthesis of these analogues. The first route uses a Ferrier-II rearrangement to provide enantiopure inositol intermediates, whereas, the second route employs a diastereomeric resolution to obtain the enantiopure inositols. The successful synthesis of InsP₃ and a series of 5-position modified analogues are reported herein.
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Wegiriya, Hemantha Chandani. "Dietary effects on instar number, instar duration and adult performance in Helicoverpa armigera." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385175.
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Rückl, Martin. "Interaction of Ca2+ with fully stochastic InsP3 receptor dynamics." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19236.
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Intrazelluläre Calcium Signale bilden einen der wichtigsten Bestandteile vieler Signalwege in der Zellbiologie. Der Fokus dieser Arbeit liegt auf der hierachischen Struktur der Calcium Muster, welche durch die Rückkopplung von Ip3 Rezeptor (Ip3R) mit Calcium verursacht wird. Auf der obersten Stufe stehen zellweite Wellen aus Calcium. Das zweite Level der Hierarchie bilden sogenante Puffs oder Sparks und entspricht der Freisetzung von Calcium von einzelnen Clustern. Das untere Ende wird durch Blibs gebildet: kleine Calcium Signale einzelner Kanäle. Die Entstehung der Calcium Wellen und der Zusammenhang mit den Ip3 Bindungszuständen individueller Ip3 Kanäle stehen dabei im Vordergund.
Ein erstes Modell verwendet ein System von Reaktions-Diffusions-Gleichungen zur Beschreibung der Calciumentwicklung in der Umgebung einzelner Cluster. Es wird festgestellt, dass ein Cluster nicht-stereotype Puffs erzeugen kann, wobei Dauer und Amplitude durch die Ip3-Konzentration moduliert werden. Stärkere Ip3-Stimulation erhöht die Wahrscheinlichkeit, lang anhaltende Freisetzungsereignisse zu beobachten, welche als die Quelle der Wellenbildung identifiziert werden. Die simulierten Daten werden mit experimentellen Ergebnissen aus Xenopus-Oozyten verglichen, wo eine ähnliche Durchsetzung der Wellen- und Puff-Muster beobachtet werden kann.
Ein zweites grobkörniges und phänomenologisches Modell auf Basis von ODEs ermöglicht das Sampling langer Trajektorien für ein größeres System aus gekoppelten Clustern mit vertretbarem Rechenaufwand. Auf einem Gitter von Clustern wird gezeigt, dass die wellenartigen Freisetzungsereignisse sich synchronisieren. Während die Wellenfrequenz mit Ip3 zunimmt, gibt es eine optimale Synchronisation für die mittlere Ip3-Anregung. Dieses Modell zeigt, dass die Terminierung der Wellen durch Dissosation von Ip3 erreicht werden kann, was dazu führt, dass sich Kanäle nicht mehr öffnen, und somit eine anhaltende Freisetzung von Ca2+ verhindert wird.The dynamics of intracellular calcium represent one of the most important signal pathways in cell biology. Within this work, the focus lies on the hierarchical structure of calcium release events emerging from the feedback of Ip3 receptor Ca2+ ion channel with Ca2+ itself. The head of this hierarchy consists of calcium waves or global oscillations. Release events from individual clusters of channels, constitute the intermediate level. Single channel release events are called blibs. This work investigates the emergence and termination of waves by using a stochastic Ip3R model with non-equilibrium Ip3 binding and discrete individual channel states. First, a system of reaction diffusion equations of calcium and buffers around a single cluster is used as a description of the calcium evolution. It is found, that a cluster can produce non stereotype puffs, where duration and amplitude are modulated by the Ip3 concentration. For increasing Ip3 stimulation, the likelihood to observe long lasting release events increases, and these events are identified as the source of wave formation. The simulated data is compared to experimental results from Xenopus oocytes, where a similar interspersion of puffs between waves can be observed. Specifically, experiments and simulations support the hypothesis of wave-like events already on a single cluster scale. The insights of the first model are then used to develop a second coarse grained and phenomenological model based on ODEs. It allows sampling of long trajectories of a system of coupled clusters with reasonable computational effort. Within a grid of coupled clusters, it is showed that the wave-like release events synchronize. While the wave frequency increases with Ip3, there is an optimal synchronization for intermediate Ip3 excitation. This model indicates that wave termination is achieved by unbinding of Ip3 from the receptor, which renders the channel unable to open, and hence prohibits any further sustained release.
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Fajnorová, Markéta. "Návrh marketingové strategie firmy Inspur Group Co. ltd. pro český trh." Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-82017.
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The diploma thesis is structured into three chapters, while the first chapter informs about theoretical concept of B-2-B marketing, defines basic specifics of B-2-B market and concerns about actual trends and frequent mistakes, which are made while preparing B-2-B marketing strategy. Next chapter informs about actual situation on the server market in the Czech Republic and mainly focuses on the external and internal environment of the firm. The last chapter is based on the personal discussion with potential distribution and service partners that provided useful information about the concurrence, actual situation on the market and defined trade requirements towards Inspur.
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Olsson, Oskar. "Samhällsnyttan av geografisk information och INSPIRE." Thesis, Uppsala universitet, Kulturgeografiska institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-167773.
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Rusch, Thomas, and Achim Zeileis. "Discussion on Fifty Years of Classification and Regression Trees." Wiley, 2014. http://dx.doi.org/10.1111/insr.12062.
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In this discussion paper, we argue that the literature on tree algorithms is very fragmented. We identify possible causes and discuss good and bad sides of this situation. Among the latter is the lack of free open-source
implementations for many algorithms. We argue that if the community adopts a standard of creating and sharing free open-source implementations for their developed algorithms and creates easy access to these programs the bad sides of the fragmentation will be actively combated and will benefit the whole scientific community. (authors' abstract)
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Funk, Annika. "Mitbestimmung in EU-Auslandsgesellschaften nach "Inspire Art" /." Baden-Baden : Nomos, 2007. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=015734153&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
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Leyman, Alexandre. "Contribution à une nouvelle voie de signalisation de l'InsP5/InsP6 via la caractérisation de l'inositol phosphate multikinase." Doctoral thesis, Universite Libre de Bruxelles, 2011. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209897.
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L’étude des inositols hautement phosphorylés est un domaine en pleine expansion. Leurs essors ne datent que d’une dizaine d’années, mais de nombreuses fonctions y sont déjà associées bien qu’ils en restent sans doute encore à découvrir. Les inositols phosphates (incluant les inositols hautement phosphorylés) s’inscrivent dans un cycle dont le représentant le plus connu est inositol 1,4,5-trisphosphate (Ins(1,4,5)P3). De ce fait, chaque inositol phosphate influence directement ou indirectement les autres membres de ce cycle.Au cours de la thèse, nous avons pu éclaircir une controverse de la littérature sur la voie de synthèse des inositols hautement phosphorylés. Grâce à un modèle de cellules MEF (mouse embryonic fibroblast) n’exprimant aucune des trois isoformes de l’inositol 1,4,5-trisphosphate 3-kinase (ITPK) et à l’aide des cellules souches déficientes pour l’inositol polyphosphate multikinase (IPMK), nous avons pu révéler le rôle majeur de cette dernière dans la génération de l’InsP5 et l’InsP6.
Dans un second temps, nous avons comparé la neurogenèse de ces cellules souches IPMK+/+ et IPMK-/- mises dans un milieu de différenciation par défaut (DDM). Les cellules dépourvues de l’IPMK entrent en apoptose et se différencient très difficilement en progéniteurs neuronaux et en neurones. Afin de comprendre le mécanisme sous-jacent pouvant expliquer ce phénomène, nous avons réalisé des PCRs quantitatives qui ont montré une sous expression des gènes du neuroectoderme ainsi qu’une augmentation de l’expression de gènes du mésoderme dans les cellules IPMK-/- par rapport aux cellules IPMK+/+. De plus, nous avons découvert que le phénomène d’apoptose observé au cours de la différenciation en DDM était spécifique à ce milieu. En effet, nous n’avons pas pu mettre en évidence un tel phénomène au cours de la différenciation en corps embryoïdes.
Durant la thèse, nous avons également développé des anticorps dirigés contre l’isoforme B de l’inositol 1,4,5-trisphosphate 3-kinase et contre la forme native de l’IPMK. Ceci nous a permis de mener à bien nos expériences et d’ouvrir de futures perspectives de recherche.
En conclusion, nous avons démontré le rôle majeur de l’IPMK dans la voie de synthèse des inositols hautement phosphorylés. Nous avons également découvert que l’IPMK est très importante pour la survie de ces cellules souches en cours de différenciation et nous avons également introduit une nouvelle fonction pour l’IPMK dans la neurogenèse.
Doctorat en Sciences biomédicales et pharmaceutiques
info:eu-repo/semantics/nonPublished
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Raijmakers, Sebastiaan W. J. J. "Design Documentaries : Using documentary film to inspire design." Thesis, Royal College of Art, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503021.
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Vanhoutte, Erik. "Microdrone équipé d'un système visuel inspiré des abeilles." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0431/document.
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De nos jours, l'engouement pour la robotique autonome ne cesse d'augmenter en particulier pour les microdrones. En effet, ces aéronefs de petite taille font l'objet de nombreuses recherches afin de les miniaturiser et de rendre leur navigation plus autonome. Ainsi, cette thèse explore un système de vision parcimonieux dédié à la navigation courte portée au moyen de capteurs visuels auto-adaptatifs innovants composés de seulement 12 pixels aux propriétés optiques inspirées de celles de l'abeille. Deux algorithmes de mesure de flux optique sont ensuite comparés en conditions idéales sur 5 décades d'irradiance et 3 décades de vitesses optiques, puis testés en conditions réelles de vol. L'algorithme le plus robuste et le plus efficace, de par ses très faibles besoins calculatoires, a été embarqué à bord d'un micro quadrirotor pesant environ 400 g et équipé d'un système visuel parcimonieux de 96 pixels stabilisé via une nacelle articulée en roulis et tangage pour compenser les rotations du quadrirotor. Les stratégies de navigation observées chez l'abeille ont ensuite été simulées dans des environnements virtuels (tunnel de longueur 6 m ou 12 m pour une section minimale de 25 ou 50 cm) et la preuve de faisabilité de la détection du flux optique à bord d'un microdrone a été démontrée en conditions réelles de vol en salle expérimentale (vol de 4 m de long à une distance minimale de 50 cm). Couplé à des stratégies de navigation inspirées de l’abeille, ce système visuel innovant dédié à la perception du mouvement permettra dans un futur proche de naviguer dans des environnements encombrés ou exigusThe interest in autonomous robotics is continually expanding, especially in the domain of micro air vehicles. Indeed, much research focuses on these small-size aircraft in order to miniaturize them and to make their navigation more autonomous. This PhD thesis explores a parsimonious vision system dedicated to short range navigation using innovative self-adaptive visual sensors composed of only 12 pixels with optical properties inspired by those of honeybees. Two optic flow measurement algorithms are first compared under ideal conditions over 5 decades of irradiance and 3 decades of optical velocity, then tested under real flight conditions. The most robust and efficient algorithm, due to its very low computing requirements, was embedded on board a micro quadrotor weighing about 400 g and equipped with a parsimonious visual system of 96 pixels stabilized via an articulated gimbal in roll and pitch to compensate the quadrotor rotations. The navigation strategies observed in honeybees were simulated in virtual environments (6 m or 12 m long tunnel for a minimum section of 25 or 50 cm) and the feasibility of the detection of the optic flow on board a micro quadrotor was demonstrated in real flight conditions in experimental room (flight of 4 m long at a minimum distance of 50 cm). Coupled with navigation strategies inspired by the honeybee, this innovative visual system dedicated to the perception of movement will in the near future allow to navigate in cluttered or cramped environments
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Santos, Leandro Alves Rodrigues dos. "Psicanálise: uma inspira-ação para a psicologia escolar?" Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/47/47131/tde-30112009-161320/.
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Investiga a possibilidade de uma inspiração pelo referencial psicanalítico na prática do psicólogo escolar. Parte da narrativa e problematização de uma intervenção realizada entre os anos de 1996 e 1997, junto a um grupo de 10 professores de primeiro grau em uma escola pública. Em 2002, retorna a essa unidade escolar e efetua pesquisa com os professores que participaram da experiência, fazendo uso de entrevistas abertas. Por meio desses testemunhos, analisa as conseqüências desse modelo de intervenção, a viabilidade dessa inspiração pelo referencial psicanalítico e a amplitude da possibilidade da extensão dos conceitos psicanalíticos na Cultura. Conclui, com base nos dados obtidos, articulando-os com a sustentação teórica dos pesquisadores do campo da intersecção entre psicanálise e educação, que a experiência possibilitou desvelar aspectos que devem ser tomados como objeto de reflexão: a formação do psicólogo para além da repetição de técnicas; a possível relação do psicólogo com a psicanálise, as implicações da transmissão dessa teoria na graduação de psicologia e as questões subjetivas de cada psicólogo que podem estar ligadas às suas escolhas. Por fim, sugere alterações na forma de transmissão de saber que ocorre nos cursos de psicologia.It investigates the possibility of an inspiration by the psychoanalitical reference at the practice of the school psychologist. Part of the narrative and problems involved which took place between 1996 and 1997, with a group of 10 teachers from elementary school in a public school. In 2002 there is a return to this school and a research with the teachers who took part in such experience is made, by means of interviews. Through these witnesses, there is an analysis of the consequences of this type of survey, the viability of this inspiration by the psychoanalitical reference and the amplitude of the possibility of the extension of the psychoanalitical concepts in Culture. It concludes that, based on data that we obtained by articulating them with the theorical backup of the field researchers of the intersection between psychoanalysis and education, which the experience made it possible to find out variables that must be taken as an objective of reflection: the background of the psychologist to the repetition of these techniques; the possible relationship between the psychologist and the psychoanalysis, the implications of the transmission of this theory at the graduation of psychology and the subjective issues of each psychologist that may be connected with their choices. Finally, is suggests changes in the ways of transmitting knowledge, which occurs in the courses of psychology.
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Scheid, Eder John. "INSpIRE : an integrated NFV-based intent refinement environment." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/169284.
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Muitos aspectos da gestão de redes de computadores, como a Qualidade de Serviço (QoS) e segurança, devem ser levados em consideração para garantir que a rede atenda às exigências de usuários e clientes. Felizmente, soluções de gestão de rede foram desenvolvidas para lidar com estes aspectos, tais como Redes Baseadas em Intenção (Intent-based Networking - IBN). IBN é um novo paradigma de rede que abstrai configurações de rede, permitindo que administradores especifiquem como a rede deve se comportar e não o que ele deve fazer. Nesta dissertação, apresentamos uma solução de IBN chamada INSpIRE (Integrated NFV-based Intent Refinement Envirorment). INSpIRE implementa uma técnica de refinamento para traduzir intenções em um conjunto de configurações para executar uma desejada cadeia de serviço em ambos, ambientes homogêneos (somente funções virtualizadas) e ambientes heterogêneos (funções virtualizadas e middleboxes físicas). A técnica de refinamento baseia-se em Requisitos Não Funcionais (Non-Functional Requirements - NFRs) e clustering para determinar quais funções de rede deverão compor a cadeia de serviços. Nossa solução é capaz de (i) determinar as funções específicas necessárias para o cumprimento de uma intenção, (ii) encadear estas funções de acordo com suas dependências e (iii) apresentar informações de baixo nível suficientes para que dispositivos de rede possam posteriormente orientar o tráfego de rede por essa cadeia de serviço. Além disso, para avaliar a viabilidade da nossa solução, estudos de caso no qual refletem situações de gestão do mundo real e uma avaliação da escalabilidade do processo de refinamento são detalhados. Por fim, os resultados mostraram que INSpIRE é capaz de fornecer uma cadeia de serviços que atende aos requisitos especificados na intenção em cenários pequenos e grandes.Many aspects of the management of computer networks, such as quality of service and security, must be taken into consideration to ensure that the network meets the users and clients demands. Fortunately, management solutions were developed to address these aspects, such as Intent-Based Networking (IBN). IBN is a novel networking paradigm that abstracts network configurations by allowing administrators to specify how the network should behave and not what it should do. In this dissertation, we introduce an IBN solution called INSpIRE (Integrated NFV-based Intent Refinement Environment). INSpIRE implements a refinement technique to translate intents into a set of configurations to perform a desired service chain in both homogeneous environments (virtualized functions only) and heterogeneous environments (virtualized functions and physical middleboxes). This refinement technique relies on Non- Functional Requirements (NFRs) and clustering to determine the network functions that will compose the service chain. Our solution is capable of (i) determining the specific functions required to fulfill an intent, (ii) chaining these functions according to their dependencies, and (iii) presenting enough low-level information to network devices for posterior traffic steering. Furthermore, to assess the feasibility of our solution we detail case studies that reflects realworld management situations and evaluate the scalability of the refinement process. Finally, the results showed that INSpIRE is capable of delivering a service chain that meets the requirements specified in the intent in small and large scenarios.
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Illert, Andreas. "Stand von INSPIRE und Geodaten-Lizenzpolitik des Bundes." Rhombos-Verlag, 2018. https://slub.qucosa.de/id/qucosa%3A35843.
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Die INSPIRE-Richtlinie der Europäischen Kommission trat 2007 in Kraft. Sie setzt den rechtlichen Rahmen für den Aufbau von Geodateninfrastrukturen und fördert damit die Interoperabilität und die gemeinsame Nutzung von Geodaten über Staatsgrenzen und Fachdisziplinen hinweg. Die Umsetzung von INSPIRE ist für deutsche Behörden verpflichtend.
Dank INSPIRE sind Geodateninfrastrukturen in Bund und Ländern inzwischen als Aufgabe der Verwaltung anerkannt. Ihr Betrieb ist durch Gesetze oder Verordnungen nachhaltig gesichert. Allerdings erfolgt die Nutzung von INSPIRE-transformierten Daten derzeit noch nicht in dem Umfang wie erhofft. Die Europäische Kommission und die Geodateninfrastruktur Deutschland haben Maßnahmen eingeleitet, um dem entgegenzuwirken.
Die gemeinsame Nutzung von Geodaten wird durch unterschiedliche Lizenzbedingungen erheblich beeinträchtigt. Sowohl innerhalb von Europa als auch innerhalb von Deutschland gibt es erhebliche Unterschiede bei den Gebühren für Geodaten. Der Bund hat für seine von INSPIRE betroffenen Geodaten im Geodatenzugangsgesetz festgelegt, dass sie grundsätzlich geldleistungsfrei über INSPIRE-konforme Dienste bereitgestellt werden.
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Williams, Sarah Phoebe. "Connections Between Inositol Phosphate Signaling and Energy Responses in Plants." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/77625.
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The ability for an organism to sense and respond appropriately to its environment is often critical for survival. One mechanism for this is the inositol phosphate (InsP) signaling pathway. This work focuses on the role of InsP signaling in maintaining energy homeostasis in the plant. InsP signaling is connected to energy sensing in plants via a protein complex containing both the inositol polyphosphate 5-phosphatases (5PTase13) and the Sucrose non-Fermenting Related Kinase 1 (SnRK1). SnRK1 is considered a fuel gauge for the plant cell that senses energy status and reprograms growth appropriately. While the SnRK1.1 gene has been well studied, the role other SnRK1 isoforms play in energy or stress signaling is less well understood. This work examined the role of 3 SnRK1 isoforms in energy signaling, finding that SnRK1.1 and SnRK1.2 are regulated and function differently in Arabidopsis. The second part of this work focuses on the inositol pyrophosphates, which are a novel group of InsP signaling molecules containing diphosphate or triphosphate chains (i.e. PPx) attached to the inositol ring. These PPx-InsPs are emerging as critical players in the integration of cellular metabolism and stress signaling in non-plant eukaryotes. Most eukaryotes synthesize the precursor molecule, myo-inositol (1,2,3,4,5,6)-hexakisphosphate (InsP6), which can serve as a signaling molecule or as storage compound of inositol, phosphorus, and minerals. Even though plants produce huge amounts of InsP6 in seeds, almost no attention has been paid to whether PPx-InsPs exist in plants, and if so, what roles these molecules play. This work details the presence of PPx-InsPs in plants and delineates two Arabidopsis gene products (AtVip1 and AtVip2) capable of PP-InsP5 synthesis. We further examined the subcellular location of enzymes connected to PPx-InsP synthesis as well as the developmental and tissue specific patterns of expression of the genes that encode these enzymes. We localized the enzymes involved in InsP6 and PPx-InsP production to the nucleus and endoplasmic reticulum (ER). The subcellular compartmentalization of PPx-InsP signaling may be unique to plants. An increased understanding in the pathways involved in energy sensing and metabolic response may reveal novel strategies to improve crops for yield and viability in the future.Ph. D.
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Thamm, Tarvo. "Untersuchungen zur Regulation des Insl3-Gens." [S.l.] : [s.n.], 2002. http://webdoc.sub.gwdg.de/diss/2003/thamm/thamm.pdf.
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Nockles, Victoria. "Investigating continental deformation using PS-InSAR." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:a6b19ec0-1310-4c66-8803-88c2430cf1d2.
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I use Persistant Scatterer Interferometric Synthetic Aperture Radar (PS InSAR) to measure interseismic strain accumulation across the Kunlun Fault, observe and model the postseismic signal associated with the Mw 7.8 2001 Kokoxili earthquake, and map strain in Western Turkey. PS InSAR selects pixels whose echo is dominated by a single scatterer in a series of interferograms (Hooper et al., 2004). To date most tectonic signals measured with InSAR have used Differential InSAR (DifSAR) rather than PS InSAR. I compare PS InSAR and DifSAR across the Kunlun Fault to obtain equivalent slip rates of 9.5 mm/yr and 10.5 mm/yr, respectively. I show that regions which are incoherent in DifSAR, are coherent using PS InSAR. Knowledge of slip rates along faults has important implication in terms of seismic hazard and is key to our understanding of the mechanical behaviour of the crust and mantle; for example they can be used to test the prediction of various models (Van Der Woerd et al., 2002). I show slip rate variability on the eastern Kunlun Fault in Tibet with rates reducing eastwards by upwards of 9 mm/yr over a region of upwards of 80 km to a slip rate of 2.4 mm/yr towards the fault tip. To date both afterslip and viscoelastic relaxation have been proposed as plausible mechanisms (Wen et al., 2012) for the Kokoxili earthquake. I model afterslip across the Kunlun Pass Fault using rate and state friction to create a series of models with various preseismic slip rates and frictional parameters. I then perform a parameter space search to find the best fitting models to ENVISAT data from 2003-2010. I compare the best fit afterslip model with viscoelastic relaxation to show that viscoelastic relaxation gives a better fit to the data. A number of studies have looked at interseismic strain accumulation across the North Anatolian and East Anatolian faults, e.g. Walters et al. (2014); Yamasaki et al. (2013), but relatively little work has been done on a fault scale across the grabens in Western Turkey. GPS data for the region shows fairly uniform strain (Aktug et al., 2009). I compare PS InSAR with GPS data to see whether the spatial resolution of the GPS is too low to resolve strain localisation. I then combine the two data sets to generate velocity and strain rate maps, which can be used for seismic hazard assessment, and to distinguish between different dynamic models of continental deformation.
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Lawlor, Fiona. "Implementation of the metadata elements of the INSPIRE directive." [Denver, Colo.] : Regis University, 2008. http://165.236.235.140/lib/FLawlor2008.pdf.
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SVENINGSON, EMIL. "Using digital tools to motivate, inspire and inform employees." Thesis, KTH, Skolan för industriell teknik och management (ITM), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-232483.
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Venkateswaran, Swaminath. "Conception d'un robot bio-inspiré pour l'inspection des canalisations." Thesis, Ecole centrale de Nantes, 2020. http://www.theses.fr/2020ECDN0024.
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Les robots d'inspection de canalisations jouent un rôle important dans des industries telles que le nucléaire, la chimie et les eaux usées. Ils peuvent opérer avec précision dans un environnement irradié ou pollué, réduisant ainsi les risques pour les humains. Cette thèse porte sur la conception d'un robot bio-inspiré pour l'inspection des canalisations. La thèse commence par l'étude du cas d'un robot d'inspection bio-inspiré rigide qui a été développé au LS2N, France pour AREVA. Des modèles statiques et dynamiques sont développés pour comprendre les forces de serrage et les couples des actionneurs du robot. Des validations expérimentales sont également effectuées sur le prototype pour interpréter les forces d’actionnement en temps réel. Pour améliorer sa mobilité, l'architecture du robot est rendue flexible par l'ajout d'un mécanisme de tenségrité. Deux types de mécanismes de tenségrité sont proposés et analysés avec des méthodes algébriques pour comprendre leurs limites d'inclinaison et pour connaître l’influence des paramètres de conception. Des expériences sont réalisées sur l'un des prototypes des mécanismes de tenségrité développés au LS2N avec deux types de trajectoire en positions horizontale et verticale. Ensuite, une optimisation est réalisée pour identifier les moteurs qui peuvent permettre du robot d'inspection de canalisation flexible de passer les coudes et les jonctions pour une plage donnée de diamètres de tuyaux. Une maquette numérique du robot flexible est réalisée dans un logiciel de CAOPiping inspection robots play an important role in industries such as nuclear, chemical and sewage. They can perform the assigned task with better accuracy and at the same time, they can operate within an irradiated or a polluted environment thereby reducing the risks for humans. This doctoral thesis focuses on the design of a bio-inspired robot for the inspection of pipelines. The thesis begins with the case study of a rigid bio-inspired piping inspection robot which was developed at LS2N, France for a project with AREVA. Static and dynamic force models are developed to understand the clamping forces and the torques on the actuators of the robot. Experimental validations are then done on the prototype to interpret the real-time actuator forces. In order to improve mobility, the robot architecture is made flexible by the addition of a Tensegrity mechanism. Two types of Tensegrity mechanisms are proposed and analyzed using algebraic methods to understand their tilt limits and to identify the influences on the design parameters. Experiments are performed on one of the prototypes of the Tensegrity mechanism developed at LS2N for two types of trajectories in the vertical and horizontal orientations. An optimization approach is then being implemented to identify the sizes of motors that can permit the flexible piping inspection robot to overcome bends and junctions for a given range of pipeline diameters. A digital model of the flexible robot is then realized in CAD software
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Houle, Marilyn. "Un modèle d'évaluation globale inspiré de la psychologie positive." Thèse, Université de Sherbrooke, 2010. http://savoirs.usherbrooke.ca/handle/11143/2826.
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Le modèle pathologique, inspiré du domaine médical, est actuellement dominant en psychologie. Ce modèle, en laissant peu de place aux aspects positifs de la personne, entraîne des biais importants dans la pratique psychothérapeutique et ceux-ci se manifestent dès le premier acte du psychologue, lors de l'évaluation psychologique. Par ailleurs, les recherches actuelles démontrent que l'évaluation des aspects positifs aurait des impacts bénéfiques tant sur le client que sur le processus thérapeutique. Certaines innovations ont récemment été proposées par l'approche positive afin d'inclure les aspects positifs de l'individu dans l'évaluation psychologique.Le présent projet vise trois principaux objectifs : l'élaboration d'un modèle d'évaluation globale inspiré de la psychologie positive, l'exploration des impacts de ce modèle sur la compréhension clinique, ainsi qu'une observation de ses impacts sur les stratégies thérapeutiques utilisées. Il s'inscrit dans le paradigme qualitatif et est de nature exploratoire. Il consiste en une recherche-action basée sur une méthodologie praxéologique qui vise à contribuer au développement des connaissances sur l'évaluation globale en psychothérapie et au développement d'un savoir professionnel en cours d'action. Au terme de cette recherche, sont ressortis un outil d'évaluation globale et un modèle de compréhension clinique, tous deux inspirés de la psychologie positive.
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Oveisgharan, Shadi. "Estimating snow accumulation from InSAR correlation observations /." May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
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Frisancho, Aldave Jorge Luis, Bernardo Cabrera Aarón Guido Israel Mendoza, and Solís Fernando Iván Valdez. "Valorización de Insur Compañía de Seguros S.A." Master's thesis, Universidad del Pacífico, 2017. http://hdl.handle.net/11354/1708.
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Insur Compañía de Seguros S.A. inició operaciones en el Perú en agosto de 2009, actualmente se dedica a la venta de pólizas de seguros de crédito interno, crédito a la exportación y cauciones. En los primeros dos casos es la empresa líder del mercado, mientras que en las cauciones, a pesar de ocupar el cuarto lugar en participación, presenta la mayor rentabilidad técnica (resultado técnico sobre primas retenidas). Asimismo, es la segunda empresa más rentable en inversiones a nivel sistema por debajo de Secrex, uno de sus competidores directos. En el presente trabajo se realizó una valorización a Insur a través del método de flujos de caja descontados y de múltiplos comparables. Respecto del primer método, se obtuvo un valor por acción de S/ 5,32; además, se realizó un análisis de sensibilidad utilizando el modelo de Montecarlo cuyos resultados no distan del escenario base. Respecto del segundo método, se seleccionaron las siguientes empresas “comparables”: Rímac, La Positiva y Mapfre Perú. El valor por acción obtenido por este método considerando el indicador enterprise value/utilidad operativa es de S/ 4,09 y, considerando el indicador enterprise value/ventas, es de S/ 1,70. Es importante resaltar que existen empresas comparables similares a Insur (es decir, que solo venden pólizas de crédito y cauciones), pero que no cotizan en sus bolsas respectivas.
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Evanshen, Pamela, and Janet Faulk. "Transforming an Elementary School: Using Constructivist Principles to Inspire Change." Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etsu-works/4362.
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Rivière, Valentin. "Vers un robot aérien autonome bio-inspiré à morphologie variable." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0061/document.
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Ce manuscrit traite de la conception d’un robot quadrirotor bio-inspiré. Ce robot, nommé QuadMorphing, s’inspire de l’oiseau et possède la capacité de se replier en vol afin de diminuer son envergure. Cette particularité est intéressante pour des problématiques d’évitement d’obstacles dans des milieux encombrés.Le travail présenté ici contient une présentation du robot où la plateforme mécatronique y est décrite en détails. Puis, des résultats expérimentaux sont présentés et commentés afin de quantifier les performances du prototype QuadMorphing durant des scénarios de franchissement d’obstacles.La deuxième partie de cette thèse traite de l’estimation de la taille d’obstacles en vol grâce à une perception visuelle monoculaire. Deux algorithmes d’estimation ont été simulés afin d’être validés pour être ensuite mis en place sur une nouvelle version du robot qui a été testée expérimentalement. Ces estimations permettent par la suite de rendre le robot plus autonome pour éviter les collisions avec son environnement et actionner son système de changement de forme si cela est nécessaireThis paper describes a bio-inspired quadrotor design. This robot, called QuadMorphing, is inspired by birds and has the ability to fold its mechanical structure to reduce its wingspan during the flight. This feature could be useful for obstacle avoidance task in cluttered environments.The work presented here contains a full description of the mechatronic structure. Then, experimental results are presented and discussed in order to quantify the QuadMorphing performances during obstacle avoidance scenarios.The second part of this thesis deals with estimating obstacle size during flight using monocular visual perception. Two estimation algorithms were simulated in order to be validated and then implemented for experimental testing on a new version of the robot. In order to make the robot autonomous, the estimation of the size of the obstacle allows the robot to avoid collisions with its environment and to perform its morphological reduction if necessary
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Copeland, Ian R. "Educate, Inspire, Change: A Musical Ethnography of World Camp, Inc." Oberlin College Honors Theses / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=oberlin1323129593.
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Drerup, Klaus. "Setup and test of a WFS for NatureSDI+ according to INSPIRE." Thesis, Högskolan i Gävle, Institutionen för teknik och byggd miljö, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-7673.
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The INSPIRE initiative requires that every European member state establishes a national SDI and related web services. Among these a WFS must be implemented to query spatial data. Therefore several Quality of Service specifications must be fullled by this web service, among these are performance, capacity and availability. In this study work a WFS will be implemented for Nature SDI plus. In this European project the WFS will provide spatial data from several data specications of ANNEX I and III. The main object is to test the conformance to the INSPIRE specification. Therefore load and performance tests will be performed.
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McWhinnie, Susan B. "Using knowledge building to inspire community inquiry in an IB classroom." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B5017695X.
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This study examines a five‐month process in which students from an International Baccalaureate (IB) school were introduced to Knowledge Building. The study occurred throughout three of the six Units of Inquiry that students cover over one year in the IB program. The transition from independent inquiry in the IB system to collective inquiry using knowledge building was aided by the Knowledge Forum software. The participants were 26 students from an international school in Hong Kong. Findings indicate that students responded positively to the knowledge building process, and showed significant of gains in knowledge in two units. Contributions to the knowledge building wall and Knowledge Forum showed evidence of some of the principles of knowledge building. Results also indicate more could have been done on the part of the teacher to promote the program. A number of recommendations for future implementations have been made.published_or_final_version
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Gallagher, Geraldine. "The alchemy of college philanthropy| What dynamics inspire the transformational gift?" Thesis, Capella University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3614800.
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Modest inquiry exists to elucidate why donors make large contributions to community colleges. Of every charitable dollar donated to education, two-year colleges receive 2 to 4 cents. This grounded theory study included 30 major donors to 23 colleges in 18 states. The questions were comprehensive: why donors and how donors make major gifts; internal and external factors, and how they work together; important synergies for cultivation, invitation, and stewardship; and why contributors choose community colleges. Six themes emerged: family history and role modeling; relationships with the college and its leaders; the desire to make a meaningful difference; the institution's role as an economic driver; a wish to give back; and donor recognition tailored to each individual. Forty percent of donors who made six- and seven-figure gifts were never invited to contribute; these extraordinary donations were unsolicited. The findings also suggest myriad recommendations for practice. Opportunities and models exist for staff to understand what inspires each unique donor. Volunteers may engage through storytelling and activism. Connections can deepen through core mission work. Colleges may expand interaction with students and faculty through shared experiences. Nurturing close relationships with major benefactors may help to engage their circles of influence. Leaders should challenge the myth that alumni give only to universities. Involving families may result in allies today and contributors tomorrow. College retirees often are excellent prospects. Donors prefer personalized recognition. Professional advisers can serve as influencers, potential conduits, and roadblocks. The two-year college fiscal model speaks to bottom-line donors. And the crucial message? It pays to ask.
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NETO, VINICIUS FREIRE. "A STORY TO TELL, MANY FOLLOWERS TO INSPIRE: A CASE STUDY." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2017. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=29946@1.
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Este trabalho tem como objetivo analisar a aplicação de storytelling pela liderança e compreender o papel desta ferramenta na disseminação e internalização dos valores organizacionais. A partir da revisão da literatura de storytelling, cultura e liderança organizacional foi realizado um estudo de caso de uma empresa privada do segmento marítimo, portuário e logístico. A pesquisa qualitativa coletou dados secundários referentes a história da organização e dados primários a partir de entrevistas semiestruturadas com quinze líderes escolhidos por conveniência e acessibilidade. Identificamos que todos os líderes entrevistados utilizam o storytelling - em maior ou menor proporção - entretanto, a grande maioria não o faz de forma consciente ou estruturada. As principais utilizações do storytelling, no estudo de caso, foram para modificação de práticas ou comportamentos, internalização de valores organizacionais e motivação da equipe, utilizando-se de histórias reais seja da própria pessoa, seja de algum gestor de nível hierárquico superior e ferramentas de apoio, tais como vídeos e fotos. Verificou-se, também, que: (1) os gestores de negócio contam histórias relativas a própria organização enquanto os gestores do corporativo utilizam histórias pessoais ou de experiências passadas e que (2) mesmo em uma organização com um passado rico e um longo caminho de histórias organizacionais, muitos dos líderes não as conhecem ou não as utilizam em suas narrativas para com seus seguidores. Por fim, recomendou-se a instrução dos principais agentes de mudança, os líderes, sobre a ferramenta de storytelling e suas melhores formas de aplicação.The present work s purpose is to analyze the application of storytelling by leaders and to comprehend the role of this tool in the dissemination and internalization of organizational values. A case study of a private company in the maritime, port terminals and logistics industries has been done considering a detailed study regarding storytelling, organizational culture and leadership. The qualitative research had collected secondary data regarding the company s history and primary data from semi-structured interviews with fifteen leaders chosen for convenience and accessibility. We identify that all interviewed leaders use storytelling - to a greater or lesser extent - however, most of them do it so in an unconscious or structured way. The interviews have showed that the reasons mentioned for using storytelling are behavioral and practices change, internalization of organizational values and team motivation, and that the stories used are mostly based on facts, like their own stories, their superior s stories or other resources (inspirational videos and photographs). It was also found that: (1) business managers tell stories about the company itself while corporate managers tell personal stories or past experiences and (2) even in an organization with vast selection of stories itself, many of the leaders do not know them or use them in their narratives. Finally, this work ends its purpose with a recommendation for the company that was to train the main agents of change, the leaders, about the tool of storytelling and its best ways of application.
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Cavnar-Lewandowski, Zoé, and Kelsey Gavin. "The Potential of Refugee Art to Inspire Empathy and Social Action." Digital Commons at Loyola Marymount University and Loyola Law School, 2017. https://digitalcommons.lmu.edu/etd/299.
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This research seeks to utilize an art experiential to explore the potential of art and art making as a means to stimulate empathy towards refugee populations. Researchers attempt to show how art can evoke empathy and inspire social action by communicating the experiences of marginalized communities, specifically Syrian refugees. This research follows a qualitative approach utilizing appropriate quantitative methodologies for data analysis. The research design includes experiential art based focus groups, implementation of guided relational viewing (Potash & Ho, 2011), surveys, response art, and verbal discussion. The data analysis observes for common themes among the three parts of the experiential, and assesses for graphic empathy (Potash & Ho, 2011) and empathic imagination (Kapitan, 2012). Our inquiry explores how participants from two groups, undergraduate studio art majors and first year art therapy graduate students, understand and relate with the experience of Syrian refugee children through art viewing and making. Researchers’ examine how these processes may act as a way to stimulate empathy and act as a catalyst for social action. After analyzing the participants’ response art and their discussions about the art viewing and making process, researchers identified four major themes distinguishing the two groups, and three major themes the groups had in common. Researchers’ examination of pre- and post-surveys on attitudes and behaviors towards refugees indicated changes that informed the conclusions of this research. Researchers conclude with a discussion of the results and how the results inform answers to the research questions and future implications.
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Khacef, Lyes. "Exploration du calcul bio-inspiré avec des architectures neuromorphiques auto-organisées." Thesis, Université Côte d'Azur, 2020. http://www.theses.fr/2020COAZ4085.
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La plasticité corticale du cerveau est l'une des principales caractéristiques qui nous permettent d'apprendre et de nous adapter à notre environnement. En effet, le cortex cérébral a la capacité de s'auto-organiser grâce à deux formes de plasticité : la plasticité structurelle qui crée ou coupe les connexions synaptiques entre les neurones, et la plasticité synaptique qui modifie la force des connexions synaptiques. Ces mécanismes sont très probablement à la base d'une caractéristique extrêmement intéressante du développement du cerveau humain : l'association multimodale. Malgré la diversité des modalités sensorielles, comme la vue, le son et le toucher, le cerveau arrive aux mêmes concepts. De plus, les observations biologiques montrent qu'une modalité peut activer la représentation interne d'une autre modalité lorsque les deux sont corrélées. Pour modéliser un tel comportement, Edelman et Damasio ont proposé respectivement la réentrance et la zone de convergence/divergence où les communications neurales bidirectionnelles peuvent conduire à la fois à la fusion multimodale (convergence) et à l'activation intermodale (divergence). Néanmoins, ces cadres théoriques ne fournissent pas de modèle de calcul au niveau des neurones.L'objectif de cette thèse est d'abord d'explorer les fondements de l'auto-organisat-ion inspirée par le cerveau en termes (1) d'apprentissage multimodal non supervisé, (2) de calcul massivement parallèle, distribué et local, et (3) de traitement efficace sur le plan énergétique. Sur la base de ces lignes directrices et d'une étude des modèles neuronaux de la littérature, nous choisissons la carte auto-organisée (SOM) proposée par Kohonen comme composant principal de notre système. Nous introduisons la grille itérative, une architecture entièrement distribuée avec une connectivité locale entre les neurones matériels qui permet un calcul cellulaire dans le SOM, et donc un système qui passe à l'échelle en termes de temps de traitement et de connectivité.Ensuite, nous évaluons la performance du SOM dans le problème de l'apprentissage non supervisé post-étiqueté : aucun label n'est disponible pendant l'entrainement, puis très peu de labels sont disponibles pour étiqueter les neurones du SOM. Nous proposons et comparons différentes méthodes d'étiquetage afin de minimiser le nombre d'étiquettes tout en conservant la meilleure précision. Nous comparons nos performances à une approche différente utilisant des réseaux neuronaux à spike (SNN).Ensuite, nous proposons d'améliorer les performances du SOM en utilisant des caractéristiques extraites au lieu de données brutes. Nous menons une étude comparative sur la classification du SOM avec extraction non-supervisée de caractéristiques à partir de la base de données MNIST en utilisant deux approches différentes : une approche d'apprentissage machine avec des auto-encodeurs convolutionnels et une approche bio-inspirée avec des SNN.Pour prouver la capacité du SOM à classifier des données plus complexes, nous utilisons l'apprentissage par transfert dvec la base de données mini-ImageNet.Enfin, nous passons au mécanisme d'association multimodale. Nous construisons le modèle bio-inspiré ReSOM basé sur les principes de réentrance en utilisant les SOMs et l'apprentissage Hebbien. Nous proposons et comparons différentes méthodes de calcul pour l'apprentissage et l'inférence multimodale non supervisée, puis nous quantifions le gain des mécanismes de convergence et de divergence sur trois bases de données multimodales. Le mécanisme de divergence est utilisé pour étiqueter une modalité à partir de l'autre, tandis que le mécanisme de convergence est utilisé pour améliorer la classification globale du système. Nous comparons nos résultats avec des SNNs, puis nous montrons le gain de la plasticité dite matérielle induite par notre modèle, où la topologie du système n'est pas fixée par l'utilisateur mais apprise au fil de l'expérience du système par l'auto-organisationThe brain's cortical plasticity is one of the main features that enable our capability to learn and adapt in our environment. Indeed, the cerebral cortex has the ability to self-organize itself through two distinct forms of plasticity: the structural plasticity that creates (sprouting) or cuts (pruning) synaptic connections between neurons, and the synaptic plasticity that modifies the synaptic connections strength. These mechanisms are very likely at the basis of an extremely interesting characteristic of the human brain development: the multimodal association. In spite of the diversity of the sensory modalities, like sight, sound and touch, the brain arrives at the same concepts. Moreover, biological observations show that one modality can activate the internal representation of another modality when both are correlated. To model such a behavior, Edelman and Damasio proposed respectively the Reentry and the Convergence Divergence Zone frameworks where bi-directional neural communications can lead to both multimodal fusion (convergence) and inter-modal activation (divergence). Nevertheless, these theoretical frameworks do not provide a computational model at the neuron level.The objective of this thesis is first to explore the foundations of brain-inspired self-organization in terms of (1) multimodal unsupervised learning, (2) massively parallel, distributed and local computing, and (3) extremely energy-efficient processing. Based on these guidelines and a review of the neural models in the literature, we choose the Self-Organizing Map (SOM) proposed by Kohonen as the main component of our system. We introduce the Iterative Grid, a fully distributed architecture with local connectivity amongst hardware neurons which enables cellular computing in the SOM, and thus a scalable system is terms of processing time and connectivity complexity.Then, we assess the performance of the SOM in the problem of post-labeled unsupervised learning: no label is available during training, then very few labels are available for naming the SOM neurons. We propose and compare different labeling methods so that we minimize the number of labels while keeping the best accuracy. We compare our performance to a different approach using Spiking Neural Networks (SNNs) with Spike Timing Dependant Plasticity (STDP) learning.Next, we propose to improve the SOM performance by using extracted features instead of raw data. We conduct a comparative study on the SOM classification accuracy with unsupervised feature extraction from the MNIST dataset using two different approaches: a machine learning approach with Sparse Convolutional Auto-Encoders using gradient-based learning, and a neuroscience approach with SNNs using STDP learning.To prove the SOM ability to handle more complex datasets, we use transfer learning in the mini-ImageNet few shot classification benchmark to exploit a Wide Residual Network backbone trained on a base dataset as a feature extractor, then we use the SOM to classify the obtained features from the target dataset.Finally, we move into the multimodal association mechanism. We build the Reentrant SOM (ReSOM), a brain-inspired neural system based on the Reentry principles using SOMs and Hebbian-like learning. We propose and compare different computational methods for multimodal unsupervised learning and inference, then quantify the gain of both convergence and divergence mechanisms on three multimodal datasets. The divergence mechanism is used to label one modality based on the other, while the convergence mechanism is used to improve the overall accuracy of the system. We compare our results to SNNs with STDP learning and different fusion strategies, then we show the gain of the so-called hardware plasticity induced by our model, where the system's topology is not fixed by the user but learned along the system's experience through self-organization
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Rollinson, Benedict Douglas. "Digital media to inspire and sustain sport participation in urban areas." Master's thesis, Faculty of Commerce, 2021. http://hdl.handle.net/11427/33007.
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This research looks to understand the role digital media plays to inspire and sustain sports participation and how digital media could be used as a socially inclusive tool. The study explores if strategically packaged digital media could be used in a socially inclusive way to increase or sustain sports participation. This would address one of the problems facing sports organisations, as sports participation is decreasing or at least stagnating both in South Africa and on a global scale. This study followed an exploratory, inductive approach, using Self-determination Theory (SDT) developed by Deci and Ryan (1985) as a theoretical framework. The paper looks to understand what research has been done to understand how people are motivated to participate in sport and the proven theories that have been tested (Pelletier et al., 1995) to understand the role of intrinsic motivation has as a powerful indicator of intention. This study made use of a qualitative, cross-sectional design and data was collected through semi-structured interviews with active participants based in Langa, Cape Town. The findings of this study showed the participants regularly accessed digital media in a manner which strongly aligned with the literature and has been shown to increase intrinsic motivation, which leads to action. The findings further show that sports media can be used as a tool for social inclusion, despite the participants socio-economic status they regularly accessed online sports content for motivational and learning purposes. Based on the findings of this research, sports organisations need to consider digital media as a viable and socially inclusive way to sustain or even increase sports participation.
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Syrén, Dania. "Creating Concept Sketches for Game Developers : Sketches that inform and inspire." Thesis, Mälardalens högskola, Akademin för innovation, design och teknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-35263.
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The objective of this project is to understand how information design– specifically informative illustration– can contribute to producing concept sketches for a science-fiction/puzzle game called Sky’s Edge. Through theoretical studies and research methods, I aimed to deepen my understanding of what makes a concept image a good one, and from that, I aimed to determine how informative illustration can help in designing and sketching the ideas that the job requester needed. The conducted theoretical studies indicated that a good concept image is one that contains ideas which are easily understood/communicated, can inspire the team, and in turn generate further discussion. They also revealed the vast advantages of thumbnail sketching– which can lead to the development of stronger ideas and compositions. Refined sketches and drawings are produced thereafter to present these ideas to the development team. The purpose of the resulting collection of concept images was to unify the visual direction of the team responsible for developing the game.
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Loiselle, Stéphane. "Traitement bio-inspiré de la parole pour système de reconnaissance vocale." Thèse, Université de Sherbrooke, 2010. http://savoirs.usherbrooke.ca/handle/11143/1952.
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Cette thèse présente un traitement inspiré du fonctionnement du système auditif pour améliorer la reconnaissance vocale. Pour y parvenir, le signal de la parole est filtré par un banc de filtres et compressé pour en produire une représentation auditive. L'innovation de l'approche proposée se situe dans l'extraction des éléments acoustiques (formants, transitions et onsets ) à partir de la représentation obtenue. En effet, une combinaison de détecteurs composés de neurones à décharges permet de révéler la présence de ces éléments et génère ainsi une séquence d'événements pour caractériser le contenu du signal. Dans le but d'évaluer la performance du traitement présenté, la séquence d'événements est adaptée à un système de reconnaissance vocale conventionnel, pour une tâche de reconnaissance de chiffres isolés prononcés en anglais. Pour ces tests, la séquence d'événements agit alors comme une sélection de trames automatique pour la génération des observations (coefficients cepstraux). En comparant les résultats de la reconnaissance du prototype et du système de reconnaissance original, on remarque que les deux systèmes reconnaissent très bien les chiffres prononcés dans des conditions optimales et que le système original est légèrement plus performant. Par contre, la différence observée au niveau des taux de reconnaissance diminue lorsqu'une réverbération vient affecter les données à reconnaître et les performances de l'approche proposée parviennent à dépasser celles du système de référence. De plus, la sélection de trames automatique offre de meilleures performances dans des conditions bruitées. Enfin, l'approche proposée se base sur des caractéristiques dans le temps en fonction de la nature du signal, permet une sélection plus intelligente des données qui se traduit en une parcimonie temporelle, présente un potentiel fort intéressant pour la reconnaissance vocale sous conditions adverses et utilise une détection des caractéristiques qui peut être utilisée comme séquence d'impulsions compatible avec les réseaux de neurones à décharges.
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Becek, Kazimierz. "Biomass Representation in Synthetic Aperture Radar Interferometry Data Sets." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-62707.
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This work makes an attempt to explain the origin, features and potential applications of the elevation bias of the synthetic aperture radar interferometry (InSAR) datasets over areas covered by vegetation.
The rapid development of radar-based remote sensing methods, such as synthetic aperture radar (SAR) and InSAR, has provided an alternative to the photogrammetry and LiDAR for determining the third dimension of topographic surfaces. The InSAR method has proved to be so effective and productive that it allowed, within eleven days of the space shuttle mission, for acquisition of data to develop a three-dimensional model of almost the entire land surface of our planet. This mission is known as the Shuttle Radar Topography Mission (SRTM). Scientists across the geosciences were able to access the great benefits of uniformity, high resolution and the most precise digital elevation model (DEM) of the Earth like never before for their a wide variety of scientific and practical inquiries.
Unfortunately, InSAR elevations misrepresent the surface of the Earth in places where there is substantial vegetation cover. This is a systematic error of unknown, yet limited (by the vertical extension of vegetation) magnitude. Up to now, only a limited number of attempts to model this error source have been made. However, none offer a robust remedy, but rather partial or case-based solutions. More work in this area of research is needed as the number of airborne and space-based InSAR elevation models has been steadily increasing over the last few years, despite strong competition from LiDAR and optical methods.
From another perspective, however, this elevation bias, termed here as the “biomass impenetrability”, creates a great opportunity to learn about the biomass. This may be achieved due to the fact that the impenetrability can be considered a collective response to a few factors originating in 3D space that encompass the outermost boundaries of vegetation. The biomass, presence in InSAR datasets or simply the biomass impenetrability, is the focus of this research.
The report, presented in a sequence of sections, gradually introduces terminology, physical and mathematical fundamentals commonly used in describing the propagation of electromagnetic waves, including the Maxwell equations. The synthetic aperture radar (SAR) and InSAR as active remote sensing methods are summarised. In subsequent steps, the major InSAR data sources and data acquisition systems, past and present, are outlined. Various examples of the InSAR datasets, including the SRTM C- and X-band elevation products and INTERMAP Inc. IFSAR digital terrain/surface models (DTM/DSM), representing diverse test sites in the world are used to demonstrate the presence and/or magnitude of the biomass impenetrability in the context of different types of vegetation – usually forest. Also, results of investigations carried out by selected researchers on the elevation bias in InSAR datasets and their attempts at mathematical modelling are reviewed.
In recent years, a few researchers have suggested that the magnitude of the biomass impenetrability is linked to gaps in the vegetation cover. Based on these hints, a mathematical model of the tree and the forest has been developed. Three types of gaps were identified; gaps in the landscape-scale forest areas (Type 1), e.g. forest fire scares and logging areas; a gap between three trees forming a triangle (Type 2), e.g. depending on the shape of tree crowns; and gaps within a tree itself (Type 3). Experiments have demonstrated that Type 1 gaps follow the power-law density distribution function. One of the most useful features of the power-law distributed phenomena is their scale-independent property. This property was also used to model Type 3 gaps (within the tree crown) by assuming that these gaps follow the same distribution as the Type 1 gaps. A hypothesis was formulated regarding the penetration depth of the radar waves within the canopy. It claims that the depth of penetration is simply related to the quantisation level of the radar backscattered signal. A higher level of bits per pixels allows for capturing weaker signals arriving from the lower levels of the tree crown.
Assuming certain generic and simplified shapes of tree crowns including cone, paraboloid, sphere and spherical cap, it was possible to model analytically Type 2 gaps. The Monte Carlo simulation method was used to investigate relationships between the impenetrability and various configurations of a modelled forest. One of the most important findings is that impenetrability is largely explainable by the gaps between trees. A much less important role is played by the penetrability into the crown cover.
Another important finding is that the impenetrability strongly correlates with the vegetation density. Using this feature, a method for vegetation density mapping called the mean maximum impenetrability (MMI) method is proposed. Unlike the traditional methods of forest inventories, the MMI method allows for a much more realistic inventory of vegetation cover, because it is able to capture an in situ or current situation on the ground, but not for areas that are nominally classified as a “forest-to-be”. The MMI method also allows for the mapping of landscape variation in the forest or vegetation density, which is a novel and exciting feature of the new 3D remote sensing (3DRS) technique.
Besides the inventory-type applications, the MMI method can be used as a forest change detection method. For maximum effectiveness of the MMI method, an object-based change detection approach is preferred. A minimum requirement for the MMI method is a time-lapsed reference dataset in the form, for example, of an existing forest map of the area of interest, or a vegetation density map prepared using InSAR datasets.
Preliminary tests aimed at finding a degree of correlation between the impenetrability and other types of passive and active remote sensing data sources, including TerraSAR-X, NDVI and PALSAR, proved that the method most sensitive to vegetation density was the Japanese PALSAR - L-band SAR system. Unfortunately, PALSAR backscattered signals become very noisy for impenetrability below 15 m. This means that PALSAR has severe limitations for low loadings of the biomass per unit area.
The proposed applications of the InSAR data will remain indispensable wherever cloud cover obscures the sky in a persistent manner, which makes suitable optical data acquisition extremely time-consuming or nearly impossible.
A limitation of the MMI method is due to the fact that the impenetrability is calculated using a reference DTM, which must be available beforehand. In many countries around the world, appropriate quality DTMs are still unavailable. A possible solution to this obstacle is to use a DEM that was derived using P-band InSAR elevations or LiDAR. It must be noted, however, that in many cases, two InSAR datasets separated by time of the same area are sufficient for forest change detection or similar applications.
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Rückl, Martin [Verfasser], Benjamin [Gutachter] Lindner, Martin [Gutachter] Falcke, and Barbara [Gutachter] Ehrlich. "Interaction of Ca2+ with fully stochastic InsP3 receptor dynamics / Martin Rückl ; Gutachter: Benjamin Lindner, Martin Falcke, Barbara Ehrlich." Berlin : Humboldt-Universität zu Berlin, 2018. http://d-nb.info/1185668144/34.
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Girau, Bernard. "Du parallélisme connexionniste à une pratique de calcul distribué numérique bio-inspiré." Habilitation à diriger des recherches, Université Nancy II, 2007. http://tel.archives-ouvertes.fr/tel-00337399.
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De nombreux travaux portent sur les réseaux de neurones artificiels appliqués à des systèmes fortement contraints (systèmes ambulatoires, systèmes autonomes, systèmes adaptatifs, etc), pour lesquels le caractère élémentaire et massivement distribué des calculs neuronaux s'avère un atout. De façon plus large, ce caractère définit la nature même des calculs connexionnistes : une puissance de calcul et une robustesse fondées sur un parallélisme massif à grain très fin où les unités de calcul s'insèrent dans un flux d'informations très dense. Il est donc indispensable de pouvoir pleinement exploiter ce parallélisme connexionniste, à la fois en termes de potentiel de calcul et en termes de perspectives d'implantations embarquées efficaces. Une partie de ces travaux s'attache à définir différentes approches d'implantation massivement parallèle de réseaux neuronaux. Une approche globale de la pratique de calcul connexionniste ne peut pas faire l'économie d'une réflexion sur les fondements de la conception des architectures connexionnistes susceptibles de résoudre un problème donné. L'essentiel des travaux sur les réseaux de neurones s'est concentré sur la définition de familles de modèles neuronaux dont l'apprentissage permet de traiter des tâches telles que classification, régression, discrimination, auto-régression, etc. Ces modèles restent d'actualité, ne serait-ce que par la variété des applications dans lesquelles ils jouent encore un rôle central, et les travaux rapportés dans ce manuscrit portent en partie sur ces modèles. Néanmoins, ils n'apparaissent le plus souvent que comme des outils de traitement statistique de données, au même titre que de nombreux autres modèles. Ils se heurtent ainsi à une barrière de complexité dans les problèmes qu'ils sont susceptibles de résoudre. Franchir "à l'aveuglette" cette barrière, c'est à dire proposer ex nihilo des architectures connexionnistes capables de réaliser des tâches cognitives complexes, ne semble pas raisonnable. De nombreux chercheurs suggèrent alors de prendre appui sur des exemples naturels de systèmes distribués capables de réaliser ces tâches. Les neurosciences sont une orientation possible. C'est cette inspiration sur la base des mécanismes observés dans le cerveau qui est proposée dans une partie des travaux rapportés dans ce manuscrit. L'objet de ces travaux n'est pas de faire le tour de l'apport possible des neurosciences pour la conception des modèles connexionnistes, mais de montrer que même dans le cas de modèles d'inspiration corticale, la défense du parallélisme connexionniste passe par une étude focalisée sur les mécanismes locaux de gestion du flux d'informations sous-jacent à ces modèles.
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Wilms, Tobias. "Die englische Ltd. in deutscher Insolvenz : nach Centros, Überseering und Inspire Art /." Baden-Baden : Nomos, 2006. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=014952715&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
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Paterson, Bethany A. "Evidence of hysteresis in the neuromuscular system of 3rd instar Sarcophaga bullata /." Connect to online version, 2008. http://ada.mtholyoke.edu/setr/websrc/pdfs/www/2008/262.pdf.
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Brahams, Caryn M. "Inspire. Empower. Live.: A design solution for the deaf and hearing-impaired." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/honors/264.
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Being "deaf" is defined as the inability to hear, but it can also be defined as a culture centered around sensibilities and shared life experiences. This endeavor seeks to integrate the hearing-impaired and hearing communities through the application of "Deaf Space" and other design theories. The result is an inspiring, empowering, and lively solution.
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Feuvrier, Audrey. "Contrôle bio-inspiré d’un sillage turbulent par stratégie passive ou auto-adaptative." Thesis, Orléans, 2015. http://www.theses.fr/2015ORLE2059/document.
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Les décollements autour d’un corps en mouvement sont à l’origine de détériorations des performances aérodynamiques, de fatigues structurelles ou de nuisances sonores. La compréhension de ces phénomènes reste encore aujourd’hui l’un des enjeux majeurs de la recherche en aérodynamique. Le développement de systèmes permettant de contrôler l’écoulement et d’altérer ou de réduire les décollements apparaît comme une solution prometteuse en vue d’améliorer les performances aérodynamiques. On distingue les systèmes de contrôles passifs, simples d’utilisation mais incapables de s’adapter aux modifications de l’écoulement, des systèmes actifs qui disposent d’une grande adaptabilité mais nécessitent un apport extérieur d’énergie pour fonctionner. La stratégie du contrôle auto-adaptif s’apparente à un compromis entre ces deux méthodes. En s’inspirant de mécanismes présents dans la nature, elle permet d’associer amélioration des performances aérodynamiques, adaptabilité et autonomie. Ce travail de thèse porte sur l’étude expérimentale du contrôle du sillage turbulent d’un corps épais à l’aide d’actionneurs bio-inspirés avec un double objectif : i. déterminer les paramètres optimaux du dispositif de contrôle qui prend la forme d’un couple de volets flexibles, ii. Identifier les mécanismes physiques d’interactions entre l’actionnement et l’écoulement. Pour mener à bien cet objectif, de nombreux instruments de mesure complémentaires ont été mis en oeuvre. Une étude paramétrique a permis de démontrer l’efficacité du dispositif pour différentes configurations (fixes et auto-adaptatives) et d’identifier des configurations d’intérêt. La caractérisation de l’écoulement autour et dans le sillage du cylindre carré sans et avec contrôle a révélé un allongement de la longueur de recirculation à l’arrière du cylindre et la réduction de l’expansion du sillage. L’un des résultats majeurs de l’étude est que la réduction de traînée obtenue est principalement liée à une action du système sur l’anisotropie des fluctuations de l’écoulement et plus particulièrement sur l’entrainement du fluide dans le sillage de l’obstacleFlow separations around moving bodies lead to detrimental effects such as aerodynamic performances loss, structural fatigue and noises production. The understanding of these phenomena remains one of the most challenging issue of modern fluid dynamics. A promising solution to improve aerodynamic performances relies on the development of flow control devices able to prevent or mitigate the effects of separation. One can distinguish the passive flow control strategy, with easy to use devices but unable to adapt to the flow changes, from the active flow control strategy which benefits from a great adaptability but requires external power supply. Self-adaptive flow control appears to be a good compromise between those two strategies. Inspired from mechanisms at play in Nature, it combines good aerodynamic performances, self-adaptability and self-sustainability. This PhD thesis is dedicated to the experimental investigation of the turbulent flow over a bluff-body controlled by means of bio-inspired devices. The objective is two-folds : i. Design the control device which consists of a couple of compliant flaps, ii. Identify the physical mechanisms governing the interactions between the flow and the devices. A great number of complementary measurement techniques have been used in order to achieve these objectives. The efficiency of the devices for different configurations – locked and self-adaptive flaps - has been demonstrated through a parametric study. It has led to the identification of the main parameters involved in the control mechanism. The flow characterization around and in the wake of both uncontrolled and controlled cylinder revealed an increase in the length of the recirculation region and the reduction of the wake width. One of the major findings of this study is that the control essentially modifies the turbulent velocity field leading to a reduction of the lateral flow entrainment in the wake of the obstacle
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Pommier, Hugo. "Placement et stockage de l'information bio-inspiré : une approche orientée agent mobile." Caen, 2010. http://www.theses.fr/2010CAEN2032.
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Cette thèse aborde la problèmatique de la gestion de l'information dans les réseaux pair à pair. L'objectif de notre approche est de fournir des mécanismes de placement et de recherche de l'information dynamiques, intelligents, robustes, et totalement décentralisés. Nous proposons une architecture en couches composée d'un réseau pair à pair responsable de la décentralisation du service, d'applications héritées de la théorie de l'information pour assurer la disponibilité et la sûreté des données, et d'agents mobiles transportant l'nformation. Nous proposons un algorithme reposant sur le déplacement en nuée des oiseaux pour placer l'information dans un réseau. Nous associons à chaque déplacement d'agent un dépôt de phéromones permettant une répartition de charge efficace, et l' établissement d'une mesure de confiance envers les pairs du réseau. Nous enrichissons ce modèle en proposant deux agents de recherche de données. Le premier agent suit une marche aléatoire également appelée chaîne de Markov. Le second agent se déplace aléatoirement et utilise ses capacités d'interaction avec l'environnement en déposant des phéromones pour marquer les pairs déjà parcourus. Enfin, nous présentons une application déployée sur un réseau physique permettant l'observation du comportement de nos agents et la validation de nos algorithmesThis thesis addresses the problem of information management in peer-to-peer networks. The goal of our approach is to provide dynamic, intelligent, strong and fully decentralized mechanisms for data placement and retrieval. We propose a layered architecture composed of a peer-to-peer network responsible of the service decentralization, applications inherited of information theory to insure data availability and reliability and mobile agents to transport data. We propose an algorithm based on the motion of bird ocks for the emplacement of information in a network. We associate to each agent movement a pheromone deposit allowing an efficient load balancing and the establishment of a trust measure between the network peers. We improve this model by proposing two data retrieval agents. The first agent follows a random walk also called Markov chain. The second one moves randomly and uses these interaction capabilities with the environment by depositing pheromones to mark visited peers. Finally, we present an application deployed on a physical network allowing the observation of our agents and the validation of our algorithms
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McClendon, Karen Susan. "Not power but beauty| How systemic sensing and engaging inspire therapeutic change." Thesis, University of Louisiana at Monroe, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10111804.
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The purpose of this dissertation is to provide a rationale and framework for a systemic praxis for Marriage and Family Therapists (MFTs) that can be utilized to increase possibilities for therapeutic change. In a time in which “common factors” are valued and MFTs generally consider themselves eclectic or integrative, there is a need for therapists to learn to cultivate a systemic praxis that allows them to effectively “juggle” all of the elements of and responsibilities inherent in the therapeutic situation. Drawing from cybernetics, systemic theory, and radical constructivism, I develop a systemic praxis for therapists which incorporates systemic ways of perceiving and engaging, improvisation, and Recursive Frame Analysis (Keeney, 1990). I develop a theory regarding the nature, impact, and utilization of what I call “systemic sensing” and ways of engaging that go beyond adherence to various aspects of therapy models. Systemic Sensing constitutes ways of seeing, hearing, sensing, and intuiting that therapists can utilize to co-create, with their clients, opportunities for therapeutic transformation.
In this dissertation, I extend Ray Ison’s (2010) framework for systemic practice to the practice of marriage and family therapy. Ison (2010) provided a metaphor of the systems practitioner as a juggler. MFTs can improve their practice by learning to juggle Maturana’s (2002, 2008) notions of languaging and emotioning, Bateson’s (1972; 1979) notion of distinguishing, and Ison’s (2010) notion of naming; the practice of and responsibilities inherent in systemic sensing; and the tailoring and contextualizing of the practice of therapy to individual clients and moments in time.
What is needed in the field of marriage and family therapy is a way of envisioning and practicing therapy that increases possibilities for change. I call for a reformation that will shift the emphasis in marriage and family therapy from model-based training into more holistic, flexible, and systemic interpersonal practices that are based on inspiring therapeutic change and healing.
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Damoiseaux, Thomas. "Untersuchungen zum Einsatz von Flugzeug-InSAR in der Gebirgskartographie." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2003. http://nbn-resolving.de/urn:nbn:de:swb:14-1044618148109-57636.
Full textAbstract:
The aim of this thesis is to determine to what extent aircraft-borne radar remote sensing can be used as the sole method for making recordings of the surface of the earth as a basis for compiling topographical and relief maps of mountainous areas. This is done using three test areas: the Edelsberg area in the Allgäu Alps and the Silvretta and Verwall Groups in the Central Alps. The basis for discussion is provided by examination of the interaction between the objects to be imaged and the radar signal, the sensor-specific characteristics thereby being taken into account. Following this some data processing and conditioning methods used for extracting information on the relief and surface coverage for preparation of cartographical products are presented. Analysis of the quality of the results shows that, measured against the requirements of mountain cartography, radar remote sensing is a practical and useful tool for making maps in Alpine regions. As the sole source of information, however, aircraft-borne radar remote sensing p roves to date to be inadequate for cartographical applications in high-mountain regionsZiel der vorliegenden Arbeit ist, festzustellen, inwieweit die flugzeuggetragene Radarfernerkundung als alleinige Erfassungsmethode der Erdoberfläche zur Erstellung von topographischen und reliefbeschreibenden Karten in Gebirgslandschaften dienen kann. Dies wird anhand von drei Testgebieten, dem Edelsberggebiet in den Allgäuer Alpen sowie der Silvretta- und Verwallgrupe in den Zentralalpen, untersucht. Die Betrachtung der Interaktion zwischen den abzubildenden Objekten und dem Radar-Signal unter Berücksichtigung der sensorspezifischen Charakteristika bildet dabei die Diskussionsgrundlage. Im weiteren werden Methoden zur Datenprozessierung und -aufbereitung vorgestellt, die eine Informa-tionsextraktion bezüglich des Reliefs und der Oberflächenbedeckung für die Erstellung kartographischer Produkte ermöglichen. Die Qualitätsanalyse der Ergebnisse zeigt, dass die Radarfernerkundung, gemessen an den Anforderungen der Gebirgskartographie, ein sinnvolles und nutzbringendes Werkzeug für die Kartenerstellung in alpinen Regionen ist. Für kartographische Anwendungen in Hochgebirgsregionen erweist sich die flugzeuggetragene Radarfernerkundung als einzige Informationsquelle bislang allerdings als nicht ausreichend
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Damoiseaux, Thomas. "Untersuchungen zum Einsatz von Flugzeug-InSAR in der Gebirgskartographie." Doctoral thesis, Technische Universität Dresden, 2002. https://tud.qucosa.de/id/qucosa%3A24199.
Full textAbstract:
The aim of this thesis is to determine to what extent aircraft-borne radar remote sensing can be used as the sole method for making recordings of the surface of the earth as a basis for compiling topographical and relief maps of mountainous areas. This is done using three test areas: the Edelsberg area in the Allgäu Alps and the Silvretta and Verwall Groups in the Central Alps. The basis for discussion is provided by examination of the interaction between the objects to be imaged and the radar signal, the sensor-specific characteristics thereby being taken into account. Following this some data processing and conditioning methods used for extracting information on the relief and surface coverage for preparation of cartographical products are presented. Analysis of the quality of the results shows that, measured against the requirements of mountain cartography, radar remote sensing is a practical and useful tool for making maps in Alpine regions. As the sole source of information, however, aircraft-borne radar remote sensing p roves to date to be inadequate for cartographical applications in high-mountain regions.Ziel der vorliegenden Arbeit ist, festzustellen, inwieweit die flugzeuggetragene Radarfernerkundung als alleinige Erfassungsmethode der Erdoberfläche zur Erstellung von topographischen und reliefbeschreibenden Karten in Gebirgslandschaften dienen kann. Dies wird anhand von drei Testgebieten, dem Edelsberggebiet in den Allgäuer Alpen sowie der Silvretta- und Verwallgrupe in den Zentralalpen, untersucht. Die Betrachtung der Interaktion zwischen den abzubildenden Objekten und dem Radar-Signal unter Berücksichtigung der sensorspezifischen Charakteristika bildet dabei die Diskussionsgrundlage. Im weiteren werden Methoden zur Datenprozessierung und -aufbereitung vorgestellt, die eine Informa-tionsextraktion bezüglich des Reliefs und der Oberflächenbedeckung für die Erstellung kartographischer Produkte ermöglichen. Die Qualitätsanalyse der Ergebnisse zeigt, dass die Radarfernerkundung, gemessen an den Anforderungen der Gebirgskartographie, ein sinnvolles und nutzbringendes Werkzeug für die Kartenerstellung in alpinen Regionen ist. Für kartographische Anwendungen in Hochgebirgsregionen erweist sich die flugzeuggetragene Radarfernerkundung als einzige Informationsquelle bislang allerdings als nicht ausreichend.
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Garthwaite, Matthew Campbell. "Deformation of Tibet : InSAR analysis and viscous flow models." Thesis, University of Leeds, 2011. http://etheses.whiterose.ac.uk/2611/.
Full textAbstract:
The Tibetan plateau in central Asia is a prime example of the distributed deformation that occurs in the lithosphere as a result of continental collision. Large scale lithospheric deformation can be estimated using viscous continuum models that balance the vertical stress induced by lateral variations of potential energy, and horizontal stress induced by tectonic boundary forces. I find that the 2-dimensional Thin Viscous Sheet (TVS) model gives a good approximation to deformation during continental collision, providing that the indenter half-width is greater than the lithospheric thickness. However even when this ratio approaches one, reasonable correspondence exists when the strain-rate exponent (n) of the rheological constitutive law is ≤ 3. By applying the TVS to model the contemporary deformation of Asia, I find that the first order features of the geodetically-determined velocity field can be explained. Models which can best predict the observed velocity field have n between 2 and 5 Argand numbers of between 1 and 4, and the strength of the Tibetan plateau and Tien Shan is between 3 and 8 times weaker than the foreland regions. Models with these parameters give a value of FL = 7-15x1012 N m-1 for the vertically integrated horizontal driving force on the Himalayan arc. I describe the π-rate method for determining slow linear deformation rates from Interferometric Synthetic Aperture Radar (InSAR) observations and validate it using synthetic data. When using real data, the π-rate method out-performs the conventional stacking method. The RMS difference between the two methods and observed GPS measurements are 3.7 and 7.1 mm/yr for π-rate and stacking respectively. I used the ~rate method to determine the interseismic velocity field across the Tibetan plateau in an approximately north-south orientated, ~1000 km-long swath using ESA Envisat data spanning a period of 6.23 years. The resulting InSAR rate map indicates a factor of 2 variation in the magnitude of line-of-sight (LOS) velocity between the latitudes of 29-40oN. Significant localisation of deformation around mapped fault zones is not observed. A deviation of up to 8 mm/yr in LOS between the InSAR rate map and GPS-derived horizontal velocity field suggests either ~8 mm/yr of vertical uplift, an additional ~20 mm/yr of eastward motion, or a combination of horizontal and vertical motion that has not been measured using horizontal-component campaign GPS data. Comparison of InSAR and GPS observations with predictions of kinematic block and viscous continuum models suggests that the latter provides a more useful description for large-scale continental deformation.
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Kioulos, Ilias P. "Behavioural responses of fourth instar Aedes aegypti (Diptera:Culcidae) larvae to Plagiorchis elegans cercariae." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80304.
Full textAbstract:
Exposure of fourth instar Aedes aegypti larvae to graded concentrations of the entomopathogenic cercariae of the digenean Plagiorchis elegans, induced fundamental changes in the partitioning of time among a number of major behavioural activities. In the absence of the parasite, swimming, breathing and feeding remained stable over time. Grooming was rarely observed. In the presence of cercariae, larvae increased grooming 26-fold. Concomitantly, feeding was reduced to 33% of control values. Times spent swimming and breathing remained unchanged. The increase in grooming activity was attributable to the attachment of cercariae to the surface of the mosquito larvae, but was independent of infection. Grooming reduced cercarial penetration. Seventy-five percent of cercariae were lost to predation by larvae, but their caloric value was insignificant and failed to compensate for the loss of feeding time due to grooming. The findings are discussed in the context of their impact on larval growth, development and survival.