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Journal articles on the topic 'INSPOC'

Author: Grafiati

Published: 26 July 2024

Last updated: 31 July 2025

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1

Lakin-Thomas, P. L. "Effects of inositol starvation on the levels of inositol phosphates and inositol lipids in Neurospora crassa." Biochemical Journal 292, no. 3 (1993): 805–11. http://dx.doi.org/10.1042/bj2920805.

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An inositol-requiring strain of Neurospora crassa was labelled during growth in liquid medium with [3H]inositol, and the levels of inositol phosphates and phosphoinositides were determined under inositol-sufficient and inositol-starved conditions. Because the mutant has an absolute requirement for inositol, the total mass of inositol-containing compounds could be determined. Inositol-containing lipids were identified by deacylation and co-migration with standards on h.p.l.c.; PtdIns3P, PtdIns4P, and PtdIns(4,5)P2 were found in approximately equal amounts, in addition to large amounts of PtdIns

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Tonk, Miray, James J. Valdés, Alejandro Cabezas-Cruz, and Andreas Vilcinskas. "Potent Activity of Hybrid Arthropod Antimicrobial Peptides Linked by Glycine Spacers." International Journal of Molecular Sciences 22, no. 16 (2021): 8919. http://dx.doi.org/10.3390/ijms22168919.

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Arthropod antimicrobial peptides (AMPs) offer a promising source of new leads to address the declining number of novel antibiotics and the increasing prevalence of multidrug-resistant bacterial pathogens. AMPs with potent activity against Gram-negative bacteria and distinct modes of action have been identified in insects and scorpions, allowing the discovery of AMP combinations with additive and/or synergistic effects. Here, we tested the synergistic activity of two AMPs, from the dung beetle Copris tripartitus (CopA3) and the scorpion Heterometrus petersii (Hp1090), against two strains of Esc

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3

McAllister III, James Thomas, and Nancy Stephanie Diaz. "Hosting Inspec on Engineering Village or Web of Science." Reference Services Review 48, no. 2 (2020): 307–17. http://dx.doi.org/10.1108/rsr-08-2019-0050.

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Purpose As library budgets continue to constrict, librarians will need to become more familiar with comparing database host platforms. This paper aims to compare Inspec on Elsevier’s Engineering Village (EV) and Clarivate’s Web of Science (WOS) from a novice user experience. The main objectives are to identify some R1 institutions that subscribe to Inspec and highlight some of the key differences between the two platforms. Design/methodology/approach Information on Inspec was gathered from various sources such as the home website, IET, and the host platform websites of Elsevier and Clarivate A

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4

Liu, Zongkai, Qian Lin, Chao Yu, et al. "Offline Multi-Agent Reinforcement Learning via In-Sample Sequential Policy Optimization." Proceedings of the AAAI Conference on Artificial Intelligence 39, no. 18 (2025): 19068–76. https://doi.org/10.1609/aaai.v39i18.34099.

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Offline Multi-Agent Reinforcement Learning (MARL) is an emerging field that aims to learn optimal multi-agent policies from pre-collected datasets. Compared to single-agent case, multi-agent setting involves a large joint state-action space and coupled behaviors of multiple agents, which bring extra complexity to offline policy optimization. In this work, we revisit the existing offline MARL methods and show that in certain scenarios they can be problematic, leading to uncoordinated behaviors and out-of-distribution (OOD) joint actions. To address these issues, we propose a new offline MARL al

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Zhou, Li Ying, Wen Ge Zuo, Qing Feng Wei, and Chang Shou Luo. "Research Profiling of Carbon Nanotubes from 2000 to 2013." Advanced Materials Research 941-944 (June 2014): 385–90. http://dx.doi.org/10.4028/www.scientific.net/amr.941-944.385.

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In order to profile the research status of carbon nanotubes (CNTs), and gasp the development direction of the subject, based on the database of INSPEC, with the help of INSPEC thesaurus, using co-word clustering, 8 important subfields of CNTs are identified in this paper. Furthermore, the trends of each subfield with time was showed as well as the journal distribution of each subfield was analyzed. The result should be focused on to provide the institutions, researchers and decision makers of CNTs with useful reference.

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Pérez Alvarez-Ossorio, J. R., M. L. Gómez Caridad, M. J. Martín Sempere, C. Galbán Ferrús, M. C. Urdin Caminos, and A. L. Sobrado Presa. "La producción de la Universidad española en Física, reflejada en las publicaciones españolas y extranjeras." Revista española de Documentación Científica 14, no. 4 (2020): 428. http://dx.doi.org/10.3989/redc.1991.v14.i4.428.

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Se analiza la producción científica de la Universidad española en el campo de la Física, y en el período 1986-88, a través de dos bases de datos: INSPEC, que recoge lo publicado en revistas extranjeras y también, aunque de modo selectivo, en cierto número de revistas españolas; e ICYT, que recoge exhaustivamente todos los trabajos originales publicados en revistas españolas. La comparación entre ambas series de datos permite deducir tendencias de publícación en el extranjero. Asimismo se analizan comparativamente los periodos 1982-85 y 1986-88, con los datos obtenidos de INSPEC.

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7

Kaznacheyeva, Elena, Vitalie D. Lupu, and Ilya Bezprozvanny. "Single-Channel Properties of Inositol (1,4,5)-Trisphosphate Receptor Heterologously Expressed in HEK-293 Cells." Journal of General Physiology 111, no. 6 (1998): 847–56. http://dx.doi.org/10.1085/jgp.111.6.847.

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The inositol (1,4,5)-trisphosphate receptor (InsP3R) mediates Ca2+ release from intracellular stores in response to generation of second messenger InsP3. InsP3R was biochemically purified and cloned, and functional properties of native InsP3-gated Ca2+ channels were extensively studied. However, further studies of InsP3R are obstructed by the lack of a convenient functional assay of expressed InsP3R activity. To establish a functional assay of recombinant InsP3R activity, transient heterologous expression of neuronal rat InsP3R cDNA (InsP3R-I, SI− SII+ splice variant) in HEK-293 cells was comb

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8

Bimboese, Patricia, Craig J. Gibson, Stefan Schmidt, Wanqing Xiang, and Barbara E. Ehrlich. "Isoform-specific Regulation of the Inositol 1,4,5-Trisphosphate Receptor by O-Linked Glycosylation." Journal of Biological Chemistry 286, no. 18 (2011): 15688–97. http://dx.doi.org/10.1074/jbc.m110.206482.

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The inositol 1,4,5-trisphosphate receptor (InsP3R), an intracellular calcium channel, has three isoforms with >65% sequence homology, yet the isoforms differ in their function and regulation by post-translational modifications. We showed previously that InsP3R-1 is functionally modified by O-linked β-N-acetylglucosamine glycosylation (O-GlcNAcylation) (Rengifo, J., Gibson, C. J., Winkler, E., Collin, T., and Ehrlich, B. E. (2007) J. Neurosci. 27, 13813–13821). We now report the effect of O-GlcNAcylation on InsP3R-2 and InsP3R-3. Analysis of AR4-2J cells, a rat pancreatoma cell line expressi

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Feriod, Colleen N., Lily Nguyen, Michael J. Jurczak, et al. "Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is reduced in obese mice, but metabolic homeostasis is preserved in mice lacking InsP3R-II." American Journal of Physiology-Endocrinology and Metabolism 307, no. 11 (2014): E1057—E1064. http://dx.doi.org/10.1152/ajpendo.00236.2014.

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Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is the most prevalent isoform of the InsP3R in hepatocytes and is concentrated under the canalicular membrane, where it plays an important role in bile secretion. We hypothesized that altered calcium (Ca2+) signaling may be involved in metabolic dysfunction, as InsP3R-mediated Ca2+ signals have been implicated in the regulation of hepatic glucose homeostasis. Here, we find that InsP3R-II, but not InsP3R-I, is reduced in the livers of obese mice. In our investigation of the functional consequences of InsP3R-II deficiency, we found that o

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Wagner, Larry E., Wen-Hong Li, Suresh K. Joseph, and David I. Yule. "Functional Consequences of Phosphomimetic Mutations at Key cAMP-dependent Protein Kinase Phosphorylation Sites in the Type 1 Inositol 1,4,5-Trisphosphate Receptor." Journal of Biological Chemistry 279, no. 44 (2004): 46242–52. http://dx.doi.org/10.1074/jbc.m405849200.

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Regulation of Ca2+release through inositol 1,4,5-trisphosphate receptors (InsP3R) has important consequences for defining the particular spatio-temporal properties of intracellular Ca2+signals. In this study, regulation of Ca2+release by phosphorylation of type 1 InsP3R (InsP3R-1) was investigated by constructing “phosphomimetic” charge mutations in the functionally important phosphorylation sites of both the S2+ and S2- InsP3R-1 splice variants. Ca2+release was investigated following expression in Dt-40 3ko cells devoid of endogenous InsP3R. In cells expressing either the S1755E S2+ or S1589E

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11

Mak, Don-On Daniel, Sean McBride, and J. Kevin Foskett. "Regulation by Ca2+ and Inositol 1,4,5-Trisphosphate (Insp3) of Single Recombinant Type 3 Insp3 Receptor Channels." Journal of General Physiology 117, no. 5 (2001): 435–46. http://dx.doi.org/10.1085/jgp.117.5.435.

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The inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R) is an endoplasmic reticulum–localized Ca2+-release channel that controls complex cytoplasmic Ca2+ signaling in many cell types. At least three InsP3Rs encoded by different genes have been identified in mammalian cells, with different primary sequences, subcellular locations, variable ratios of expression, and heteromultimer formation. To examine regulation of channel gating of the type 3 isoform, recombinant rat type 3 InsP3R (r-InsP3R-3) was expressed in Xenopus oocytes, and single-channel recordings were obtained by patch-clamp elect

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12

Lee, B., PG Bradford, and SG Laychock. "Characterization of inositol 1,4,5-trisphosphate receptor isoform mRNA expression and regulation in rat pancreatic islets, RINm5F cells and betaHC9 cells." Journal of Molecular Endocrinology 21, no. 1 (1998): 31–39. http://dx.doi.org/10.1677/jme.0.0210031.

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The inositol 1,4,5-trisphosphate receptor (InsP3R) is an intracellular Ca2+ channel that plays a role in the regulation of insulin secretion. In rat isolated pancreatic islets the expression of types I, II and III InsP3R mRNA was identified by reverse transcriptase-polymerase chain reaction and confirmed by cDNA cloning and sequencing. The islet ratios of types I, II and III InsP3R mRNA to beta-actin mRNA were 0.08 +/- 0.02, 0.08 +/- 0.03 and 0.25 +/- 0.04 respectively. Types I, II and III InsP3R mRNA were also expressed in rat (RINm5F) and mouse (betaHC9) pancreatic beta-cell lines, and rat c

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13

Fujimoto, T., A. Miyawaki, and K. Mikoshiba. "Inositol 1,4,5-trisphosphate receptor-like protein in plasmalemmal caveolae is linked to actin filaments." Journal of Cell Science 108, no. 1 (1995): 7–15. http://dx.doi.org/10.1242/jcs.108.1.7.

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We reported that a plasmalemmal inositol 1,4,5-trisphosphate receptor-like protein (PM InsP3R-L) is localized in caveolae of various non-neuronal cells in vivo (Fujimoto et al. (1992) J. Cell Biol. 119, 1507–1513). In the present study, we investigated the distribution of PM InsP3R-L in cultured cells. In mouse epidermal keratinocytes (Pam 212) cultured in standard Ca2+ (1.8 mM), PM InsP3R-L was distributed densely in the vicinity of cell-to-cell contacts. In contrast, when Pam cells were cultured in low Ca2+ (0.06 mM) without making cell-to-cell contacts, PM InsP3R-L was observed randomly; by

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DeLisle, S., O. Blondel, F. J. Longo, W. E. Schnabel, G. I. Bell, and M. J. Welsh. "Expression of inositol 1,4,5-trisphosphate receptors changes the Ca2+ signal of Xenopus oocytes." American Journal of Physiology-Cell Physiology 270, no. 4 (1996): C1255—C1261. http://dx.doi.org/10.1152/ajpcell.1996.270.4.c1255.

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The receptors for the second messenger inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] form a family of closely related proteins that play an important role in regulating the free intracellular Ca2+ concentration. To test the hypothesis that changing the expression level of Ins(1,4,5)P3 receptors could alter the Ins(1,4,5)P3-mediated Ca2+ signal, we overexpressed Ins(1,4,5)P3 receptor type 1 (InsP3R-1) or type 3 (InsP3R-3) in Xenopus laevis oocytes. Expression of InsP3R-1 increased the velocity of the propagating waves of intracellular Ca2+ release but did not affect the Ins(1,4,5)P3-induced entry

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Mak, Don-On Daniel, Sean McBride, and J. Kevin Foskett. "Atp-Dependent Adenophostin Activation of Inositol 1,4,5-Trisphosphate Receptor Channel Gating." Journal of General Physiology 117, no. 4 (2001): 299–314. http://dx.doi.org/10.1085/jgp.117.4.299.

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The inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R) is a ligand-gated intracellular Ca2+ release channel that plays a central role in modulating cytoplasmic free Ca2+ concentration ([Ca2+]i). The fungal metabolite adenophostin A (AdA) is a potent agonist of the InsP3R that is structurally different from InsP3 and elicits distinct calcium signals in cells. We have investigated the effects of AdA and its analogues on single-channel activities of the InsP3R in the outer membrane of isolated Xenopus laevis oocyte nuclei. InsP3R activated by either AdA or InsP3 have identical channel conduct

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Joseph, J. Donald, Yi Peng, Don-On Daniel Mak, et al. "General Anesthetic Isoflurane Modulates Inositol 1,4,5-Trisphosphate Receptor Calcium Channel Opening." Anesthesiology 121, no. 3 (2014): 528–37. http://dx.doi.org/10.1097/aln.0000000000000316.

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Abstract Background: Pharmacological evidence suggests that inhalational general anesthetics induce neurodegeneration in vitro and in vivo through overactivation of inositol trisphosphate receptor (InsP3R) Ca2+-release channels, but it is not clear whether these effects are due to direct modulation of channel activity by the anesthetics. Methods: Using single-channel patch clamp electrophysiology, the authors examined the gating of rat recombinant type 3 InsP3R (InsP3R-3) Ca2+-release channels in isolated nuclei (N = 3 to 15) from chicken lymphocytes modulated by isoflurane at clinically relev

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S. Jude, Yasser, and Wafaa Al-Hameed. "Toward Salient Key Phrase for Candidate Topic Detection." Kufa Journal of Engineering 16, no. 2 (2025): 215–33. https://doi.org/10.30572/2018/kje/160213.

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With exponential growth of digital information, the need for efficient methods for automatic keyphrase extraction has become increasingly important. Key phrase candidate topic detection (KPCTD) aims to automatically identify key phrases, i.e., phrases that capture the central meaning of a text document and associate them with their corresponding topics. We have developed an innovative method that combines statistical with contextual approaches ( position and distance criteria in addition to semantic information). We present a comprehensive approach to text analysis; it enables the use of a har

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Mak, Don-On Daniel, Sean McBride, and J. Kevin Foskett. "Atp Regulation of Recombinant Type 3 Inositol 1,4,5-Trisphosphate Receptor Gating." Journal of General Physiology 117, no. 5 (2001): 447–56. http://dx.doi.org/10.1085/jgp.117.5.447.

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A family of inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R) Ca2+ release channels plays a central role in Ca2+ signaling in most cells, but functional correlates of isoform diversity are unclear. Patch-clamp electrophysiology of endogenous type 1 (X-InsP3R-1) and recombinant rat type 3 InsP3R (r-InsP3R-3) channels in the outer membrane of isolated Xenopus oocyte nuclei indicated that enhanced affinity and reduced cooperativity of Ca2+ activation sites of the InsP3-liganded type 3 channel distinguished the two isoforms. Because Ca2+ activation of type 1 channel was the target of regulati

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Bezprozvanny, I., and B. E. Ehrlich. "Inositol (1,4,5)-trisphosphate (InsP3)-gated Ca channels from cerebellum: conduction properties for divalent cations and regulation by intraluminal calcium." Journal of General Physiology 104, no. 5 (1994): 821–56. http://dx.doi.org/10.1085/jgp.104.5.821.

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The conduction properties of inositol (1,4,5)-trisphosphate (InsP3)-gated calcium (Ca) channels (InsP3R) from canine cerebellum for divalent cations and the regulation of the channels by intraluminal Ca were studied using channels reconstituted into planar lipid bilayers. Analysis of single-channel recordings performed with different divalent cations present at 55 mM on the trans (intraluminal) side of the membrane revealed that the current amplitude at 0 mV and the single-channel slope conductance fell in the sequence: Ba (2.2 pA, 85 pS) &gt; Sr (2.0 pA, 77 pS) &gt; Ca (1.4 pA, 53 pS)

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Vais, Horia, J. Kevin Foskett, and Don-On Daniel Mak. "Unitary Ca2+ current through recombinant type 3 InsP3 receptor channels under physiological ionic conditions." Journal of General Physiology 136, no. 6 (2010): 687–700. http://dx.doi.org/10.1085/jgp.201010513.

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The ubiquitous inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R) channel, localized primarily in the endoplasmic reticulum (ER) membrane, releases Ca2+ into the cytoplasm upon binding InsP3, generating and modulating intracellular Ca2+ signals that regulate numerous physiological processes. Together with the number of channels activated and the open probability of the active channels, the size of the unitary Ca2+ current (iCa) passing through an open InsP3R channel determines the amount of Ca2+ released from the ER store, and thus the amplitude and the spatial and temporal nature of Ca2+

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Striggow, F., and B. E. Ehrlich. "The inositol 1,4,5-trisphosphate receptor of cerebellum. Mn2+ permeability and regulation by cytosolic Mn2+." Journal of General Physiology 108, no. 2 (1996): 115–24. http://dx.doi.org/10.1085/jgp.108.2.115.

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The inositol 1,4,5-trisphosphate receptor (InsP3R), an intracellular calcium release channel, is found in virtually all cells and is abundant in the cerebellum. We used Mn2+ as a tool to study two aspects of the cerebellar InsP3R. First, to investigate the structure of the ion pore, Mn2+ permeation through the channel was determined. We found that Mn2+ can pass through the InsP3R; the selectivity sequence for divalent cations is Ba2+ &gt; Sr2+ &gt; Ca2+ &gt; Mg2+ &gt; Mn2+. Second, to begin characterization of the cytosolic regulatory sites responsible for the Ca(2+)-dependent

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Ramos-Franco, Josefina, Daniel Galvan, Gregory A. Mignery, and Michael Fill. "Location of the Permeation Pathway in the Recombinant Type 1 Inositol 1,4,5-Trisphosphate Receptor." Journal of General Physiology 114, no. 2 (1999): 243–50. http://dx.doi.org/10.1085/jgp.114.2.243.

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The inositol 1,4,5-trisphosphate receptor (InsP3R) forms ligand-regulated intracellular Ca2+ release channels in the endoplasmic reticulum of all mammalian cells. The InsP3R has been suggested to have six transmembrane regions (TMRs) near its carboxyl terminus. A TMR-deletion mutation strategy was applied to define the location of the InsP3R pore. Mutant InsP3Rs were expressed in COS-1 cells and single channel function was defined in planar lipid bilayers. Mutants having the fifth and sixth TMR (and the interceding lumenal loop), but missing all other TMRs, formed channels with permeation prop

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MACKRILL, John J., Robert A. WILCOX, Atsushi MIYAWAKI, Katsuhiko MIKOSHIBA, Stefan R. NAHORSKI, and R. A. John CHALLISS. "Stable overexpression of the type-1 inositol 1,4,5-trisphosphate receptor in L fibroblasts: subcellular distribution and functional consequences." Biochemical Journal 318, no. 3 (1996): 871–78. http://dx.doi.org/10.1042/bj3180871.

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InsP3 receptor (InsP3R)/Ca2+-release channels differ markedly in abundance in different tissues/cell types and InsP3R expression levels may be modulated in response to a variety of external cues. Cell lines overexpressing InsP3Rs will provide useful models for the study of the influence of receptor density and subtype on InsP3-mediated Ca2+ signalling. We have investigated the properties of InsP3Rs in mouse L fibroblast cell lines transfected with either type-1 InsP3R cDNA (L15) or vector control (Lvec). L15 cells express approximately eightfold higher levels of the type-1 InsP3R protein than

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Ionescu, Lucian, Carl White, King-Ho Cheung, et al. "Mode Switching Is the Major Mechanism of Ligand Regulation of InsP3 Receptor Calcium Release Channels." Journal of General Physiology 130, no. 6 (2007): 631–45. http://dx.doi.org/10.1085/jgp.200709859.

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The inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R) plays a critical role in generation of complex Ca2+ signals in many cell types. In patch clamp recordings of isolated nuclei from insect Sf9 cells, InsP3R channels were consistently detected with regulation by cytoplasmic InsP3 and free Ca2+ concentrations ([Ca2+]i) very similar to that observed for vertebrate InsP3R. Long channel activity durations of the Sf9-InsP3R have now enabled identification of a novel aspect of InsP3R gating: modal gating. Using a novel algorithm to analyze channel modal gating kinetics, InsP3R gating can be se

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Mak, Don-On Daniel, Sean McBride, Viswanathan Raghuram, Yun Yue, Suresh K. Joseph, and J. Kevin Foskett. "Single-Channel Properties in Endoplasmic Reticulum Membrane of Recombinant Type 3 Inositol Trisphosphate Receptor." Journal of General Physiology 115, no. 3 (2000): 241–56. http://dx.doi.org/10.1085/jgp.115.3.241.

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The inositol 1,4,5-trisphosphate receptor (InsP3R) is an intracellular Ca2+-release channel localized in endoplasmic reticulum (ER) with a central role in complex Ca2+ signaling in most cell types. A family of InsP3Rs encoded by several genes has been identified with different primary sequences, subcellular locations, variable ratios of expression, and heteromultimer formation. This diversity suggests that cells require distinct InsP3Rs, but the functional correlates of this diversity are largely unknown. Lacking are single-channel recordings of the recombinant type 3 receptor (InsP3R-3), a wi

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Badia, Giovanna. "Multiple Databases are Needed to Search the Journal Literature on Computer Science." Evidence Based Library and Information Practice 10, no. 4 (2015): 241. http://dx.doi.org/10.18438/b8p31c.

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A Review of: Cavacini, A. (2015). What is the best database for computer science journal articles? Scientometrics 102(3): 2059-2071. http://dx.doi.org/10.1007/s11192-014-1506-1  Objective – To compare the coverage of computer science literature in four bibliographic databases by checking the indexing of a selection of journal articles. The purpose of this comparison was to identify the most comprehensive database in computer science and determine whether more than one database is needed to search for articles on computer science topics.   Design – Comparative data

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Delti Kurnia, Septika Rudiamon, and Ramesh Prasad Adhikary. "Utilizing the Inshot Application as A Distance Learning Video." Journal International Inspire Education Technology 1, no. 1 (2022): 11–20. http://dx.doi.org/10.55849/jiiet.v1i1.28.

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Distance learning at this time results in low delivery of learning materials and learning objectives are not achieved optimally, because teachers only give assignments without learning video learning media, so students do not really understand the learning material, teachers must make learning media at the same time. distance learning by utilizing advanced technology such as using inshot editing applications in learning videos. The goal is for teachers to better know, understand, and increase knowledge about the use of the inshot video editing application as a learning video editing applicatio

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Mak, Don-On Daniel, Sean M. J. McBride, Nataliya B. Petrenko, and J. Kevin Foskett. "Novel Regulation of Calcium Inhibition of the Inositol 1,4,5-trisphosphate Receptor Calcium-release Channel." Journal of General Physiology 122, no. 5 (2003): 569–81. http://dx.doi.org/10.1085/jgp.200308808.

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The inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R), a Ca2+-release channel localized to the endoplasmic reticulum, plays a critical role in generating complex cytoplasmic Ca2+ signals in many cell types. Three InsP3R isoforms are expressed in different subcellular locations, at variable relative levels with heteromultimer formation in different cell types. A proposed reason for this diversity of InsP3R expression is that the isoforms are differentially inhibited by high cytoplasmic free Ca2+ concentrations ([Ca2+]i), possibly due to their different interactions with calmodulin. Here, w

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Lièvremont, J. P., A. M. Hill, M. Hilly, and J. P. Mauger. "The inositol 1,4,5-trisphosphate receptor is localized on specialized sub-regions of the endoplasmic reticulum in rat liver." Biochemical Journal 300, no. 2 (1994): 419–27. http://dx.doi.org/10.1042/bj3000419.

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Inositol 1,4,5-trisphosphate (InsP3) is involved in the mobilization of Ca2+ from intracellular non-mitochondrial stores. In rat liver, it has been shown that the InsP3-binding site co-purifies with the plasma membrane. This suggests that in the liver the InsP3 receptor (InsP3R) associates with plasma membrane. We studied the subcellular distribution of the liver InsP3R by measuring the maximal binding capacity of [3H]InsP3 and using antibodies against the 14 C-terminal residues of the type 1 InsP3R. The antibodies recognized a large amount of an InsP3R protein of 260 kDa in a membrane fractio

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Rezi, Melisa, and Adam Mudinilllah. "Utilization of the Inshot Application as a Learning Media." Al-Madrasah: Jurnal Pendidikan Madrasah Ibtidaiyah 6, no. 2 (2022): 278. http://dx.doi.org/10.35931/am.v6i2.949.

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<p><em>This study aims to explain the use and how to edit the inshot video editing application as a learning medium in elementary schools during the COVID-19 pandemic. This study uses a qualitative descriptive research method by describing the inshot application to receive an explanation of the use and use of the inshot application in making a video-based learning media. In the current era, digital technology has developed very rapidly in the world, including Indonesia. And this includes education as a result, due to the COVID-19 pandemic. So, the solution given by the government a

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Guntoro, Tri Setyo, Ansar C. S, and Nasruddin Nasruddin. "PENINGKATAN KETERAMPILAN MEMBUAT VIDEO PENDUKUNG PEMBELAJARAN MENGGUNAKAN APLIKASI INSHOT DAN VN BAGI GURU OLAHRAGA DI MGMP KOTA JAYAPURA." Journal of Community Empowerment 1, no. 2 (2022): 75. http://dx.doi.org/10.31764/joce.v1i2.11203.

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ABSTRAK Kegiatan Pengabdian kepada Masyarakat ini bertemakan “peningkatan keterampilan membuat video pendukung pembelajaran menggunakan aplikasi Inshot dan VN bagi Guru Olahraga di MGMP Kota Jayapura”. Tujuan pengabdian yaitu peserta dapat: (1) Memahami pengertian editing video, jenis-jenis editing video, tujuan dan Manfaat editing video, (2) Memahami dan mempraktekkan Aplikasi Inshot dalam pembuatan media pembelajaran PJOK, (3) Memahami dan mempraktekkan Aplikasi VN dalam pembuatan media pembelajaran PJOK. Menggunakan metode presentasi dengan tiga tahapan yaitu, (1) Fasilitator mempresentasik

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Hidayah, Nurul, Nur Hasanah, and M. Fuat Asnawi. "EVALUASI USABILITY DALAM USER EXPERIENCE DENGAN METODE SYSTEM USABILITY SCALE PADA APLIKASI INSHOT." Journal of Economic, Business and Engineering (JEBE) 4, no. 1 (2022): 162–71. https://doi.org/10.32500/jebe.v4i1.5600.

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Penelitian ini dilakukan guna mengetahui tingkat kelayakan dan kegunaan aplikasi editor video berbasis mobile menggunakan metode System Usability Scale (SUS) dengan interpretasi percentiles rank, grades, adjectives, acceptable, Net Promotore Score (NPS). Evaluasi Usability ini bertujuan untuk mengetahui apakah aplikasi InShot masih memerlukan perbaikan atau tidak. Selain itu, tingkat kenyaman juga perlu diketahui berdasarkan pengalaman pengguna. Hasil penelitian tentang Evaluasi Usability Dalam User Experience Pada Aplikasi Mobile InShot Dengan Metode System Usability Scale, dapat diketahui ba

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Nurviyani, Vina, and Luthfita Aulia Dewia. "Composing Digital Multimodal Notices Using the InShot Application as Learning Media." Linguistics and ELT Journal 10, no. 2 (2022): 41. http://dx.doi.org/10.31764/leltj.v10i2.11974.

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Digital technology has become very influential globally, particularly in developing learners' writing skills. This study investigated the implementation of the InShot application in creating digital multimodal notices. Moreover, it explored the strengths and weaknesses of the InShot app applied as the learning media in composing digital multimodal notices. The study used qualitative design (a case study) involving 27 students studying at a junior high school in West Java. Observations, open-ended questionnaires, and documents were applied to the data collection. The result shows that implement

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Олексій, Васильєв, та Чьочь Вікторія. "НАУКОМЕТРИЧНІ ТА ПАТЕНТНІ ДОСЛІДЖЕННЯ ПРОБЛЕМ КІБЕРБЕЗПЕКИ В ЕНЕРГЕТИЦІ". Моделювання та інформаційні технології, № 88 (25 грудня 2019): 21–25. https://doi.org/10.5281/zenodo.3873101.

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У статті  представлені результати науково-метричного  та патентного аналізу науково-технічних публікацій (патентних документів), що проіндексовані у базах даних INSPEC та PatentScope  і присвячені проблемам кібербезпеки енергетичних систем та енергетичного обладнання. Проаналізовано бібліометричні дані за двадцять років (1999 – 2019 рр). Визначені хронологічна динаміка публікування (патентування), рейтинг країн реєстрації авторів публікацій  і визначені тенденції.

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Valério, Patricia, C. C. P. Mendes, Marivalda Pereira, Alfredo Goes, and M. Fatima Leite. "Glutamate Release by Osteoblasts in the Presence of Ionic Products from Bioactive Glass 60S." Key Engineering Materials 284-286 (April 2005): 537–40. http://dx.doi.org/10.4028/www.scientific.net/kem.284-286.537.

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Osteoblasts constitutively release glutamate and this release appears to be regulated by calcium entry. In this work we investigated if the bioactive glass with 60% of silicon (BG60S) could alter glutamate release by osteoblasts. We demonstrated that osteoblasts incubated with medium containing ionic products from the dissolution of BG60S showed lower release of glutamate when compared to control. Since intracellular calcium (Cai 2+) increase is required for glutamate release we investigated the subcellular distribution of the calcium channel inositol triphosphate receptors (InsP3Rs) in the pr

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Maria, Anly, and Muhamad Azis Nurahman. "Penggunaan Multimedia Inshot Dalam Meningkatkan Pemahaman Siswa Pada Mata Pelajaran Al-Qur’an Hadis." Masagi 2, no. 1 (2023): 193–202. http://dx.doi.org/10.37968/masagi.v2i1.534.

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Pemahaman siswa merupakan kemampuan memahami masalah, menginterpretasikan dan menyatakan kembali dengan kata-kata sendiri. Dalam pemahaman keterampilan yang harus dikuasai oleh siswa adalah keterampilan menerjemahkan, menghubungkan, dan menafsikan. Namun, kenyataanya pemahaman siswa pada mata pelajaran Al Qur’an Hadis kelas XI MIPA di MA Al-Musaddadiyah Garut masih rendah, hal ini dibuktitkan dengan temuan peneliti terhadap rendahnya pemahaman siswa, seperi: tidak bisa menjelaskan materi yang telah disampaikan dan menyimpulkan materi menggunakan kata-kata sendiri. Hasil dari observasi niali ul

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Szabat, Marta, Dan S. Luciani, James M. Piret та James D. Johnson. "Maturation of Adult β-Cells Revealed Using a Pdx1/Insulin Dual-Reporter Lentivirus". Endocrinology 150, № 4 (2008): 1627–35. http://dx.doi.org/10.1210/en.2008-1224.

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The enigmatic process of β-cell maturation has significant implications for diabetes pathogenesis, and potential diabetes therapies. This study examined the dynamics and heterogeneity of insulin and pancreatic duodenal homeobox (Pdx)-1 gene expression in adult β-cells. Insulin and Pdx1 expression were monitored in human and mouse islet cells and MIN6 cells using a Pdx1-monomeric red fluorescent protein/insulin-enhanced green fluorescent protein dual-reporter lentivirus. The majority of fluorescent cells were highly positive for both Pdx1 and insulin. Cells expressing Pdx1 but little or no insu

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Van Pelt, R. E., E. M. Evans, K. B. Schechtman, A. A. Ehsani, and W. M. Kohrt. "Contributions of total and regional fat mass to risk for cardiovascular disease in older women." American Journal of Physiology-Endocrinology and Metabolism 282, no. 5 (2002): E1023—E1028. http://dx.doi.org/10.1152/ajpendo.00467.2001.

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The aim of this study was to determine whether trunk fat mass, measured by dual-energy X-ray absorptiometry (DEXA), is predictive of insulin resistance and dyslipidemia, independently of arm and leg fat mass, in postmenopausal women. Total and regional body composition was measured by DEXA in 166 healthy, postmenopausal women (66 ± 4 yr). Four primary markers of insulin resistance and dyslipidemia were assessed: 1) area under the curve for the insulin (INSAUC) response to an oral glucose tolerance test (OGTT), 2) product of the OGTT glucose and insulin areas (INSAUC×GLUAUC), 3) serum triglycer

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Nur Iman Putri Kertamuda, Dwi Yulianti, and Muhammad Nur Wahiddin. "Pemanfaatan Media Pembelajaran Video Berbantuan Inshot di Bidang MIPA (A Systematic Literature Review)." JURNAL PENDIDIKAN MIPA 14, no. 4 (2024): 1143–52. https://doi.org/10.37630/jpm.v14i4.2125.

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Media pembelajaran adalah alat atau perantara yang mendukung pembelajaran berbasis teknologi antara pendidik dan pelajar. Salah satu contoh media tersebut yakni media audio visual, yang merupakan istilah lain untuk media yang dapat dilihat dan didengar sekaligus. Menonton video setelah atau sebelum membaca buku dapat membantu siswa memahami pelajaran. Tujuan pembuatan artikel adalah untuk memaparkan manfaat dari media video dalam pembelajaran dengan bantuan aplikasi edit Inshot di bidang MIPA. Hasilnya menggunakan deskriptif analisis dan menggunakan Sistematika Literature Review (SLR) untuk me

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Roderick, H. L., and M. D. Bootman. "Bi-directional signalling from the InsP3 receptor: regulation by calcium and accessory factors." Biochemical Society Transactions 31, no. 5 (2003): 950–53. http://dx.doi.org/10.1042/bst0310950.

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Calcium is a pleiotropic messenger controlling a diverse array of intracellular events from fertilization to cell death. One of the main mechanisms by which intracellular calcium is elevated is through InsP3 [Ins(1,4,5)P3]-induced mobilization of calcium from its receptor on the endoplasmic reticulum calcium store. The activity of the InsP3R (InsP3 receptor) is subject to regulation by many factors other than InsP3, most notably calcium itself, which regulates the channel in a bell-shaped dependent manner. InsP3R sensitivity is also regulated by post-translational modifications such as phospho

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Cruz, Pablo, Ulises Ahumada-Castro, Galdo Bustos, et al. "Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells." International Journal of Molecular Sciences 22, no. 2 (2021): 651. http://dx.doi.org/10.3390/ijms22020651.

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T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy whose chemoresistance and relapse persist as a problem despite significant advances in its chemotherapeutic treatments. Mitochondrial metabolism has emerged as an interesting therapeutic target given its essential role in maintaining bioenergetic and metabolic homeostasis. T-ALL cells are characterized by high levels of mitochondrial respiration, making them suitable for this type of intervention. Mitochondrial function is sustained by a constitutive transfer of calcium from the endoplasmic reticulum to mitoc

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Cruz, Pablo, Ulises Ahumada-Castro, Galdo Bustos, et al. "Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells." International Journal of Molecular Sciences 22, no. 2 (2021): 651. http://dx.doi.org/10.3390/ijms22020651.

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T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy whose chemoresistance and relapse persist as a problem despite significant advances in its chemotherapeutic treatments. Mitochondrial metabolism has emerged as an interesting therapeutic target given its essential role in maintaining bioenergetic and metabolic homeostasis. T-ALL cells are characterized by high levels of mitochondrial respiration, making them suitable for this type of intervention. Mitochondrial function is sustained by a constitutive transfer of calcium from the endoplasmic reticulum to mitoc

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DAVIS, Richard J., R. A. John CHALLISS, and Stefan R. NAHORSKI. "Enhanced purinoceptor-mediated Ca2+ signalling in L-fibroblasts overexpressing type 1 inositol 1,4,5-trisphosphate receptors." Biochemical Journal 341, no. 3 (1999): 813–20. http://dx.doi.org/10.1042/bj3410813.

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Mouse L-fibroblast cells stably transfected with either type 1 Ins(1,4,5)P3 receptor (InsP3R) cDNA (L15) or the vector control (Lvec) have been used to investigate the functional consequences of increased InsP3R density on receptor-mediated Ca2+ signalling. L15 cells express approx. 8-fold higher levels of the type 1 InsP3R compared with Lvec cells, which endogenously express essentially only the type 1 InsP3R protein. Stimulation of Lvec and L15 cells with UTP or ATP increased cytosolic Ca2+ concentration to a greater extent in L15 cells at all agonist concentrations. UTP and ATP were equipot

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Ramos, Jorge, Wonyong Jung, Josefina Ramos-Franco, Gregory A. Mignery, and Michael Fill. "Single Channel Function of Inositol 1,4,5-trisphosphate Receptor Type-1 and -2 Isoform Domain-Swap Chimeras." Journal of General Physiology 121, no. 5 (2003): 399–411. http://dx.doi.org/10.1085/jgp.200208718.

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The InsP3R proteins have three recognized domains, the InsP3-binding, regulatory/coupling, and channel domains (Mignery, G.A., and T.C. Südhof. 1990. EMBO J. 9:3893–3898). The InsP3 binding domain and the channel-forming domain are at opposite ends of the protein. Ligand regulation of the channel must involve communication between these different regions of the protein. This communication likely involves the interceding sequence (i.e., the regulatory/coupling domain). The single channel functional attributes of the full-length recombinant type-1, -2, and -3 InsP3R channels have been defined.

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Park, Hyung Seo, Matthew J. Betzenhauser, Yu Zhang, and David I. Yule. "Regulation of Ca2+ release through inositol 1,4,5-trisphosphate receptors by adenine nucleotides in parotid acinar cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 302, no. 1 (2012): G97—G104. http://dx.doi.org/10.1152/ajpgi.00328.2011.

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Secretagogue-stimulated intracellular Ca2+ signals are fundamentally important for initiating the secretion of the fluid and ion component of saliva from parotid acinar cells. The Ca2+ signals have characteristic spatial and temporal characteristics, which are defined by the specific properties of Ca2+ release mediated by inositol 1,4,5-trisphosphate receptors (InsP3R). In this study we have investigated the role of adenine nucleotides in modulating Ca2+ release in mouse parotid acinar cells. In permeabilized cells, the Ca2+ release rate induced by submaximal [InsP3] was increased by 5 mM ATP.

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Vais, Horia, J. Kevin Foskett, Ghanim Ullah, John E. Pearson, and Don-On Daniel Mak. "Permeant calcium ion feed-through regulation of single inositol 1,4,5-trisphosphate receptor channel gating." Journal of General Physiology 140, no. 6 (2012): 697–716. http://dx.doi.org/10.1085/jgp.201210804.

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The ubiquitous inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R) Ca2+ release channel plays a central role in the generation and modulation of intracellular Ca2+ signals, and is intricately regulated by multiple mechanisms including cytoplasmic ligand (InsP3, free Ca2+, free ATP4−) binding, posttranslational modifications, and interactions with cytoplasmic and endoplasmic reticulum (ER) luminal proteins. However, regulation of InsP3R channel activity by free Ca2+ in the ER lumen ([Ca2+]ER) remains poorly understood because of limitations of Ca2+ flux measurements and imaging techniques. H

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DARGAN, Sheila L., Edward J. A. LEA, and Alan P. DAWSON. "Modulation of type-1 Ins(1,4,5)P3 receptor channels by the FK506-binding protein, FKBP12." Biochemical Journal 361, no. 2 (2002): 401–7. http://dx.doi.org/10.1042/bj3610401.

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FK506-binding protein (FKBP12) is highly expressed in neuronal tissue, where it is proposed to localize calcineurin to intracellular calcium-release channels, ryanodine receptors and Ins(1,4,5)P3 receptors (InsP3Rs). The effects of FKBP12 on ryanodine receptors have been well characterized but the nature and function of binding of FKBP12 to InsP3R is more controversial, with evidence for and against a tight interaction between these two proteins. To investigate this, we incorporated purified type-1 InsP3R from rat cerebellum into planar lipid bilayers to monitor the effects of exogenous recomb

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Yule, D. I., S. V. Straub, and J. I. E. Bruce. "Modulation of Ca2+ oscillations by phosphorylation of Ins(1,4,5)P3 receptors." Biochemical Society Transactions 31, no. 5 (2003): 954–57. http://dx.doi.org/10.1042/bst0310954.

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Activation of InsP3Rs (InsP3 receptors) represents the major mechanism underlying intracellular calcium release in non-excitable cells such as hepatocytes and exocrine cells from the pancreas and salivary glands. Modulation of calcium release through InsP3Rs is therefore a major route whereby the temporal and spatial characteristics of calcium waves and oscillations can potentially be ‘shaped’. In this study, the functional consequences of phosphoregulation of InsP3Rs were investigated. Pancreatic and parotid acinar cells express all three types of InsP3R in differing abundance, and all are po

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О.В., Васильєв, та Чьочь В.В. "Наукометричні та патентні дослідження проблем кібербезпеки в енергетиці". Моделювання та інформаційні технології. Зб. наук. пр. ІПМЕ ім. Г.Є. Пухова НАН України, № 88 (15 грудня 2019): 16–19. https://doi.org/10.5281/zenodo.3859631.

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The article presents the results of scientometric and patent analysis of scientific and technical publications (patent documents), which are indexed in the INSPEC and PatentScope databases and devoted to the problems of cybersecurity of power systems and power equipment. Bibliometric data for twenty years (1999 – 2019) are analyzed. The chronological dynamics of publishing (patenting), the rating of countries of registration of authors of publications have been determined and the trends have been determined.

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Nathanson, M. H., A. F. O'Neill, and A. D. Burgstahler. "Primitive organization of cytosolic Ca(2+) signals in hepatocytes from the little skate Raja erinacea." Journal of Experimental Biology 202, no. 22 (1999): 3049–56. http://dx.doi.org/10.1242/jeb.202.22.3049.

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Cytosolic Ca(2+) (Ca(i)(2+)) signals begin as polarized, inositol 1, 4,5-trisphosphate (InsP3)-mediated Ca(i)(2+) waves in mammalian epithelia, and this signaling pattern directs secretion together with other cell functions. To investigate whether Ca(i)(2+) signaling is similarly organized in elasmobranch epithelia, we examined Ca(i)(2+) signaling patterns and InsP3 receptor (InsP3R) expression in hepatocytes isolated from the little skate, Raja erinacea. Ca(i)(2+) signaling was examined by confocal microscopy, InsP3R expression by immunoblot, and the subcellular distribution of InsP3Rs by imm

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