Dissertations / Theses on the topic 'Instabilité structurale'
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Ravy, Sylvain. "Étude des instabilités structurales dans les conducteurs organiques." Paris 11, 1988. http://www.theses.fr/1988PA112333.
Full textSchneider, Dominique. "Plasticité génomique chez streptomyces ambofaciens dsm40697 : analyses structurale et transcriptionnelle d'un point chaud de délétion." Nancy 1, 1993. http://www.theses.fr/1993NAN10244.
Full textRebib, Farida. "Etude structurale, optique et électrique de couches minces d'oxynitrure de silicium déposées par pulvérisation cathodique radiofréquence réactive." Phd thesis, Université Blaise Pascal - Clermont-Ferrand II, 2006. http://tel.archives-ouvertes.fr/tel-00717306.
Full textBonello, Bernard. "Instabilites structurales induites sous pression dans les composes de structure perovskite." Paris 6, 1989. http://www.theses.fr/1989PA066557.
Full textMohamed, Salah-Eldin A. "Elastic-plastic instability of plane frames." Diss., Georgia Institute of Technology, 1989. http://hdl.handle.net/1853/12092.
Full textKhumbah, Fidelis Morfaw. "Instability of three-dimensional frameworks." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315305.
Full textKasperski, Johan. "Confrontation des données de terrain et de l'imagerie multi-sources pour la compréhension de la dynamique des mouvements de versants." Phd thesis, Université Claude Bernard - Lyon I, 2008. http://tel.archives-ouvertes.fr/tel-00380467.
Full textHuard, Mickaël. "Instabilités structurales de cristaux moléculaires apériodiques." Rennes 1, 2009. http://www.theses.fr/2009REN1S144.
Full textThis thesis concerns the study of the urea – alkane family which are prototypes composites. Their main characteristic is the incommensurability which exists between the cell parameters of the two host guest sublattices. Since the 1980's, it's known that aperiodic crystals get back periodicity in crystallography superspaces of dimensions larger than 3. In this work, we focus on the phase transitions within these superspaces showing the multiplication of structural solutions. With the help of the versatility of the guest family (alkane molecules) within the host matrix, we illustrate the competition between the antagonistic interactions which favour incommensurability or lock-in. The very high spatial resolution needed for such studies was obtained combining cold neutron diffraction, high resolution X ray and synchrotron diffraction and coherent diffraction on synchrotron source
Marcel, Thibaud. "Simulation numérique et modélisation de la turbulence statistique et hybride dans un écoulement de faisceau de tubes à nombre de Reynolds élevé dans le contexte de l'interaction fluide-structure." Thesis, Toulouse, INPT, 2011. http://www.theses.fr/2011INPT0109/document.
Full textThe prediction of fluid-elastic instabilities that develop in a tube bundle is of major importance for the design of modern heat exchangers in nuclear reactors, to prevent accidents associated with such instabilities. The fluid-elastic instabilities, or flutter, cause material fatigue, shocks between beams and damage to the solid walls. These issues are very complex for scientific applications involving the nuclear industry. This work is a collaboration between EDF, CEA and IMFT. It aims to improve the numerical simulation of the fluid-structure interaction in the tube bundle, in particular in the range of critical parameters contribute to the onset of damping negative system and the fluid-elastic instability
Podevin, Marie. "Instabilité structurelle et économétrie des politiques économiques." Paris 1, 2004. http://www.theses.fr/2004PA010053.
Full textZhu, Huaxiang. "Prise en compte d'une échelle intermédiaire dans la modélisation micro-structurelle des sols granulaires." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAI094/document.
Full textGranular materials exhibit a wide spectrum of constitutive features under various loading paths. Developing constitutive models which succeed to characterize these features has been challenging scientists for decades. A promising direction of achieving this can be the multi-scale approach. Through which the constitutive model is formulated in the way that relating material's macroscopic properties to their micro-scale essences, namely, corresponding micro-structure properties.To better characterize the micro-structure and formulate the relation between different scales, a comprehensive investigation have been carried out on the basis of numerical biaxial tests using 2D discrete element method (DEM), in order to ascertain the micro-structure characteristics of the granular material, the way they evolve versus loading and their corresponding rules in the macroscopic behaviors. In a meso-scale, intermediate between the single contact scale and the macro-scale, the force transmission network (force-chains) and area element enclosed by contacts branches (meso-loops) are highlighted in terms of their significant influences on material's macro-scale behavior. Meso-loops herein are tessellated from the whole area of the granular assembly by the contact branch network, and are subsequently categorized according to their side number.The development of meso-loops is observed to be intimately related to material's volumetric evolution, especially the plastic part. Then, the interaction between force-chains and meso-loops and its significance to the global volumetric behavior are revealed. Otherwise, in critical state, an identical meso-structure is found in the failure area of both localized and diffuse failure mode. Meso-loops with 3 sides (L3) appear to be indispensable for the force-chain stability, meanwhile, meso-loops with more than or equal to 6 sides (L6+) contribute much to the volume expansion and accelerate the force-chain buckling. The interplay between L3 and L6+ largely embody, or are representative of, the various mechanical performance of the granular material.A constitutive model has been developed by modifying the H-directional model. In this model, individual hexagons, representatives of L6+, construct the fabric as distributing along different directions in the space. Then multi-scale approach is then used to relate macroscopic properties from local ones, and eventually, to give the constitutive relation. This model is then validated in different loading paths, and eventually proved satisfying
Andreopoulos, Spyridon. "Aggregate labour market dynamics and structural instability." Thesis, Birkbeck (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439103.
Full textWang, Lixiao. "From protein sequence to structural instability and disease." Doctoral thesis, Umeå : Department of Chemistry, Umeå University, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-33845.
Full textStults, Dawn Michelle. "STRUCTURAL INSTABILITY OF HUMAN RIBOSOMAL RNA GENE CLUSTERS." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_diss/68.
Full textCorner, Quinten. "Torsional buckling and instability of steel structural members." Master's thesis, University of Cape Town, 2003. http://hdl.handle.net/11427/5056.
Full textHe, Mingzhe. "Insight into galloping instability of a multi-degree-of-freedom slender structure with structural and aerodynamic couplings." Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.705480.
Full textWu, Hongbo. "The effects of structural dynamics for the flutter instability of fundamental structural sections." 京都大学 (Kyoto University), 2005. http://hdl.handle.net/2433/145386.
Full text0048
新制・課程博士
博士(工学)
甲第11227号
工博第2438号
新制||工||1327(附属図書館)
22836
UT51-2004-U433
京都大学大学院工学研究科環境地球工学専攻
(主査)教授 松本 勝, 教授 稲室 隆二, 助教授 白土 博通
学位規則第4条第1項該当
Cerqueira, Stéphane. "Étude du couplage aéro-mécanique au sein des moteurs à propergol solide." Thesis, Paris, ENMP, 2012. http://www.theses.fr/2012ENMP0011/document.
Full textFluid Structure Interaction of an inhibitor with the internal flow induced by wall injection was studied in an axisymmetric cold flow apparatus. Experiments were carried out over a wide range of injection velocities in order to underline how the obstacle not only modifies the mean flowfield but also its entire dynamic behaviour.The resulting instability (from the interaction of the unstable shear layer with the Taylor-Culick flow) exhibits a significant shift with respect to the Taylor-Culick instability and therefore emphasizes the strong impact of the inhibitor on hydrodynamics.The mecanisms responsible of such behaviour are studied in this thesis with the help of global linear stability analysis and multi-physics numerical computations
Doaré, Olivier. "Instabilités locales et globales en interaction fluide-structure." Palaiseau, Ecole polytechnique, 2001. http://www.theses.fr/2001EPXX0038.
Full textPinettes, Claire. "Magnétisme itinérant : frustration, instabilité et anisotropie." Grenoble 1, 1993. http://www.theses.fr/1993GRE10035.
Full textDelon, Antoine. "Instabilité de flapping : origine et effets sur la structure et le spray d'un jet atomisé." Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAI074/document.
Full textJet or sheet atomized by a fast coaxial gas jet is currently used in industry, like aeronautical propulsion (turbofan) or spatial propulsion (cryotechnic rocket engine). Many physical processes allows liquid coherent structure fragmentation into drops. Stripping, which appears downstream near injector, has been largely studied (Marmottant et Villermaux 2004, Hong & al 2004), mecanisms has been correctly described.However, the origin of large scale - or 'flapping' instabilities - intervening further downstream, instabilities that are causing the production of large drops, remains poorly understood. This is particularly true for cylindrical jets which, unlike the case of sheets, have been the subject of very few studies. We are therefore committed to understand the origin of the "flapping", to analyze its relationship with interfacial shear instabilities, and to quantify its impact on the structure of the jet as well as on the drops produced. For this, experiments were carried out in water/air on wide set of parameters, both in terms of phasic speed than the dimensions of the gas gap and liquid diameter. Special care were made to the internal flow control.For all the geometries, we showed that the length of the liquid cone is driven by the large scale displacements and not by the stripping process. Furthermore, the length of brokenness jet presents a decline marked with the gas speed, then remains constant beyond a critical gas speed. A model was proposed for this asymptotic behavior in which the break-up length is driven by the report of the liquid injection speed to a capillary speed built on the liquid diameter.Measurement of the frequency of large scale displacement technology has been implemented from images acquired by shadowgraphy proved operational over the gas velocity range considered. This frequency, which varies not spatially, present two behaviors: a first where it increases with the speed of the gas, and a second where it remains independent of the gas speed. This second scheme is not mentioned in the literature. For the original plan, the link between flapping and shear instability has been demonstrated based on analyses of stability. The associated Strouhal number is controlled by the shear gas side. The dependence of the frequency of heartbeat to the thickness of vorticity gas side is thus established when shear instability is driven by an inviscide mechanism. For the second scheme, the opportunistic nature of the flapping has been demonstrated using forcing experience: the flapping amplifies liquid structures of wavelength greater than those associated with shear instability. A Strouhal number built on liquid jet diameter and the speed of the liquid jet at break distance has been proposed. Finally, the ratio of the diameter of the liquid jet at the wavelength of the shear instability seems relevant to define the border between these two regimes.Sizes drops produced on the symmetry axis were measured using an optical probe. It appears that granulometric distribution is evolving strongly with speed gas, and it is multi-modal, reflecting the presence of several mechanisms of brokenness. The average size of the drops decreases overall as UG - 2, in the limit of strong numbers of aerodynamic Weber. This medium size is also very sensitive to geometry: it decreases when the thickness of the gas increases until it reaches a floor value, and it grows with the liquid diameter. Finally, by forcing large amplitude lateral displacement, the average radial distribution of sizes of drops has been made much more homogeneous, and the average size of the drops on the axis has been reduced by a factor of 2. These results therefore open opportunities in terms of control of atomization
Gunes, G. "Genome structure and instability associated with transposition in Streptomyces." Thesis, Swansea University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.637187.
Full textBéziel, Wilfried. "Instabilité autophobique et structure de l'interface de films minces de polymères." Doctoral thesis, Universite Libre de Bruxelles, 2010. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210134.
Full textUn ralentissement de la dynamique du démouillage a été montré pour les plus faibles épaisseurs de films de polystyrène linéaire. Nous avons observé que l’angle de contact du polystyrène linéaire sur le réseau augmente avec le temps alors que la longueur de glissement diminue. Les phénomènes mis en jeu pour ces variations d’angle de contact et de longueur de glissement sont reliés à la structure de l’interface. Il a été mesuré que pendant le démouillage il y a une pénétration des chaînes de polystyrène dans le réseau plus importante avec de plus faible densité de réticulation. Cette pénétration a pour effet d’étirer les mailles du réseau et ainsi de diminuer l’entropie de la surface, ce qui favorise le mouillage en augmentant l’angle de contact. En même temps, les chaînes qui ont partiellement pénétrer vont jouer le rôle de connecteur entre le film et le réseau en créant des points d’enchevêtrement avec les chaînes du film, ce qui ralentit la cinétique du démouillage.
Le démouillage pour les systèmes avec la densité de réticulation la plus faible (taux d’azoture 17%), a un comportement de type semi-idéal pour la vitesse de démouillage ("v∝" "t" ^"-1/3" ). Le gonflement d’un réseau plus dense (taux d’azoture de 62%) est moins efficace :la saturation complète est impossible, même pour les temps longs.
Nous avons également étudié la cinétique de la formation d’une interface entre deux films de polymère dans le cas stable. Le polymère utilisé est la polyoléfine, c’est un copolymère statistique d’éthylène et de butène. Le ratio entre les deux monomères dans les films va modifier le degré d’immiscibilité du système. L’épaisseur de l’interface est liée à une partie intrinsèque qui se forme rapidement, et une autre aux ondes capillaires. Nous avons pu observer leurs croissances pour un système proche du point critique d’immiscibilité, et ainsi remonté aux propriétés viscoélastiques du système.
Doctorat en Sciences
info:eu-repo/semantics/nonPublished
Pons, Benoit. "Etude de l'activité de la Cytolethal Distending Toxin et des dommages induits en mitose." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30170.
Full textThe Cytolethal Distending Toxin (CDT) is a virulence factor produced by several Gram-negative pathogenic bacteria. CDT is involved in the pathogenicity of producing bacteria and promotes long-term persistence of infection and inflammation. Moreover, CDT can to induce DNA damage in infected cells, classifying CDT as a genotoxin. CDT thus induces genomic instability which, concomitantly with inflammation promotion, is probably the cause of the reported association between CDT and carcinogenesis. The effects of the genotoxin rely on the CdtB catalytic subunit, but uncertainty however persists on its exact mode of action. Based on sequence and structure alignment with DNase I, CdtB has been proposed to be a nuclease and its activity is supposedly measureable by an in vitro bacterial plasmid degradation assay. This test has been largely used in literature, but inconsistencies have been reported in nuclease activity evaluation. Moreover, sequence alignment with specific phosphatases targeting phosphoinositides suggested a similar activity for CdtB. However, the significance of each biochemical activity on CDT toxicity is not yet characterized, and overall, their impacts on CDT-associated pathologies are not well understood to this day. In order to characterize the biochemical activities of CdtB, we generated and used several mutated toxins. In a first study, comparison between cellular effects and in vitro plasmid digestion assay determined that this test is unsuited to study CdtB biochemical activity. We instead propose to use cellular assays relying on the evaluation of CDT-induced DNA damage response. These tests were then used to evaluate the impact of different mutations on CdtB activity. Most of these mutations aimed to decouple both activities, especially by targeting residues potentially involved in substrates binding. The mutants allowed to determine that toxicity is mainly linked to nuclease activity while phosphatase activity is probably involved in intracellular trafficking of the toxin. Other generated mutants targeted a region strictly conserved with a human endonuclease presenting similar characteristic with CdtB, and preliminary results are presented. Finally, the last part of my thesis focused on the study of CDT impact on cell cycle and genomic instability. This project, based on a live-cell time-lapse microscopy approach, highlighted the CDT-induced mitotic defaults, especially an increase of metaphase/anaphase transition duration. In conclusion, this thesis permitted firstly to better characterize the relationship between CdtB biochemical activities and CDT toxic effects, and secondly to study its participation in genomic instability induction. Overall, this characterization of CDT mode of action represents a first step to get more insight on the pathogenesis it can induce
Dikandé, Alain Moïse. "Fluctuations quantiques et instabilités structurales dans les conducteurs à basse dimensionalité." Thèse, Université de Sherbrooke, 2004. http://hdl.handle.net/11143/5832.
Full textBurrell, R. A. "Replication stress links structural and numerical chromosomal instability in colorectal cancer." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1383596/.
Full textINCH, OSCAR FABRICIO ZULETA. "FINITE ELEMENTS WITH SPLINE FUNCTIONS APPLIED TO STRUCTURAL DYNAMICS AND INSTABILITY." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2008. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=12139@1.
Full textCOORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR
No presente trabalho se estuda um elemento finito subparamétrico que aproxima o campo de deslocamentos com funções spline, implementando um programa que pode ser utilizado para calculo estático, dinâmico e de instabilidade de estruturas compostas de placas, vigas de paredes finas, vigas caixão e em geral em elementos alongados (pontes e perfis metálicos). O grau de liberdade de rotação perpendicular ao plano do elemento é introduzido na formulação para possibilitar uma análise tridimensional. Apresenta-se um método que serve como base para determinar a constante de rigidez correspondente. Nos exemplos apresentados avalia-se a precisão obtida utilizando pouco número de divisões longitudinais do continuo, vantagem que justifica o uso desses elementos em estudos de pré-projeto ou otimização de estruturas. Comparam-se os resultados com soluções teóricas ou resultados de outros programas estruturais, permitindo apreciar as possibilidades e limitações da modelagem usando elementos finitos com funções spline. As diferenças observadas, que surgem principalmente em placas espessas, são explicadas pela aproximação da deformação de cisalhamento encontrada na literatura para os elementos utilizados na comparação. Mostra-se também exemplos de instabilidade analisados em três dimensões que permitem considerar diferentes condições de apoio e discutir os resultados de fórmulas conhecidas.
The present work presents a subparametric finite element model with spline displacement functions, implemented for static, dynamic and instability analysis of folded plates, thin-walled beams, box girders, and elongated structures such as bridges and structural shapes. A drilling degree of freedom (rotation about an axis perpendicular to the plane of the element) is introduced in the formulation to allow for three-dimensional analysis. A method for determining the corresponding contribution to the stiffness matrix is presented. The examples presented evaluate the accuracy obtained using a small number of longitudinal subdivisions of the continuum, convenient in the case of analyses for preliminary design and optimization. The results obtained are compared to theoretical solutions or results of standard structural analysis programs, allowing for an appraisal of the advantages and limitations of modeling with use of spline functions. The differences in the results, observed specially in the case of thick plates, are explained by the approximations for the shear strain in the elements used for comparison. From the examples it is possible to comment results of threedimensional modeling of instability problems with different boundary conditions.
ORLANDO, DIEGO. "NONLINEAR DYNAMICS, INSTABILITY AND CONTROL OF STRUCTURAL SYSTEMS WITH MODAL INTERACTION." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2010. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=16177@1.
Full textO objetivo desta tese de doutorado é estudar a influência do acoplamento de modos de flambagem no comportamento estático e particularmente no comportamento dinâmico não-linear de elementos estruturais suscetíveis a flambagem. Para isto, usam-se dois modelos discretos conhecidos por seu complexo comportamento não-linear: o modelo de Augusti e um modelo de torre estaiada com dois graus de liberdade. Inicialmente estuda-se a estabilidade dos dois modelos perfeitos, incluindo a obtenção de todos os caminhos de equilíbrio pré- e pós-críticos e o efeito das imperfeições na capacidade de carga da estrutura e na estabilidade dos diversos caminhos de equilíbrio. O objetivo desta análise é entender como as diversas soluções pós-críticas instáveis e as imperfeições influenciam a geometria da superfície de energia potencial, o contorno do vale potencial pré-crítico e a integridade da estrutura frente a inevitáveis perturbações externas. A seguir estuda-se o comportamento dos modelos em vibração livre. Após a identificação das freqüências naturais, dos modos lineares de vibração e das ressonâncias internas, estuda-se, com o objetivo de entender a dinâmica dos modelos, usando as ferramentas da mecânica Hamiltoniana, a geometria da região segura que circunda a posição de equilíbrio pré-crítica, cuja estabilidade se deseja preservar, e as variedades invariantes dos pontos de sela que definem esta região. Ainda, no contexto da análise das vibrações livres, determinam-se todos os modos não-lineares de vibração, sua estabilidade e sua relação freqüência-amplitude. Estes modos não-lineares estáveis e instáveis, que surgem em virtude do acoplamento modal e das simetrias dos modelos, controlam e explicam a sua dinâmica sob vibração forçada. Com base nesses resultados, estuda-se o comportamento dos modelos sob uma excitação de base, através de um estudo sistemático de bifurcações globais e locais, e a integridade das soluções estáveis através da evolução e estratificação das bacias de atração e das medidas de integridade dinâmica. Finalmente estuda-se como aumentar a segurança da estrutura através do controle das bifurcações globais homoclínicas e heteroclínicas. A presente tese revela um conjunto de comportamentos que são típicos dos dois modelos e que podem ser entendidos como fenômenos característicos de estruturas que exibem acoplamento modal. Assim, a principal contribuição deste trabalho reside na identificação de algumas características e aspectos particulares dessa classe de estruturas, assunto inédito na literatura.
The aim of this thesis is to study the influence of coupled buckling modes on the static and particularly on the nonlinear dynamic behavior of structural components liable to buckling. For this, two discrete two degrees of freedom models known for their complex nonlinear behavior are selected: the well-known Augusti’s model and a simplified model of cable-stayed tower. Initially, the stability analysis of the perfect models is conducted, including the identification of all pre- and post-critical equilibrium paths, and the effect of imperfections on the load capacity of the structure and stability of the various equilibrium paths. The purpose of this analysis is to understand how the various unstable post-critical solutions and imperfections influence the geometry of the potential energy surface, the contour of the pre-buckling potential well and the integrity of the structure under the inevitable external disturbances. Then the behavior of the models in free vibration is investigated, including the identification of the natural frequencies, linear vibration modes and possible internal resonance. To understand the dynamics of the models, the geometry of the safe region surrounding the pre-buckling equilibrium position and the invariant manifolds of saddle points that define this region are obtained using the tools of Hamiltonian mechanics. Also, as part of the free vibrations analysis, all stable and unstable nonlinear vibration modes and their frequency-amplitude relations are obtained. These nonlinear stable and unstable modes, which arise due to modal coupling and the symmetries of the models, control and explain the dynamics of the model under forced vibration. Based on these results, we study the behavior of the models subjected to a base excitation through a systematic study of the global and local bifurcations, and the integrity of stable solutions through the evolution and stratification of the basins of attraction and dynamic integrity measures. Finally, we study how to increase the safety of the structure through the control of global homoclinic and heteroclinic bifurcations. This thesis identifies a number of behaviors that are typical of the two models and can be understood as characteristic phenomena of structures exhibiting modal coupling. Thus the main contribution of this work is to identify certain characteristics and particular aspects of this class of structures, a first contribution to this research area.
Saury, Eléonore. "Turbulence et instabilité thermique du milieu interstellaire atomique neutre : une approche numérique." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00784196.
Full textKortava, Ekaterina. "Structural instability in the pricing-to-market and exchange rate pass-through." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4787/.
Full textGuo, Rongbing. "Biochemical and structural characterization of BLM Helicase." Paris 11, 2008. http://www.theses.fr/2008PA112168.
Full textBloom's syndrome (BS) is an autosomal recessive disorder, showing high frequency of sister chromatid exchange in lymphocyte of the patients. Since BS is preposition of a wide spectrum of cancer, the syndrome has been studied for understanding of the mechanism of cancer extensively. Ln the first part, we proved the existence of a zinc-binding domain in which a zinc ion is coordinated by four cysteines residues in RecQ-Ct domain of BLM. This conclusion is drawn from our biophysical and biochemical studies. We modeled the 3D structure of BLM protein based on that of E. Coli RecQ helicase, which revealed a similar structural domain in both helicases that coordinate zinc. The results from experiments with three mutants showed that their enzymatic activities were severely reduced or abrogated. The demetalization of zinc from BLM had no influence on the activities of BLM, but it would decrease the themostability of the protein. Ln conclusion, BLM contains a zinc binding domain with one zinc ion in each protein. The second part of our studies includes the work for understanding of causative molecular mechanism of missense mutations which happened in helicase domain of BLM found in BS patients. On the basis of the work inthe fist part, we further modeled the 3D structure of BLM in complex with A TPyS and DNA. With the model, we deduced the possible causative mechanism of mutants. We produced mutant proteins and purified them to homogeneity. The A TPase activity, A TP binding activity, DNA binding activity and helicase activity ofthe mutants were ail checked. Ln conclusion 1 showed that: 1. BLM642-129o possibly employ an "inchworm" model mechanism; 2. Amino acid residues from 861 to 901 are imprtant for DNA binding; 3. DNA binding ofBLM is mainly controlled by lobe2 and lobe3, lobel contribute to a transient ssDNA binding; 4. The annealing activity of RecQ helicase suggests a weak DNA binding activity
Woodward, Jessica Christina. "Cell-lineage-specific chromosomal instability in condensin II mutant mice." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/22921.
Full textChiu, Hsin-Yao. "Family Structure and Family Instability: Evaluating Their Influence on Adult Outcomes." BYU ScholarsArchive, 2012. https://scholarsarchive.byu.edu/etd/3398.
Full textMazel, Vincent. "Structure et dynamique du ruissellement sous un surplomb." Paris 7, 1999. http://www.theses.fr/1999PA077160.
Full textSantos, Andreia Esteves. "Modeling and numerical simulation of the flexibility and structural instability of cardiovascular stents." Master's thesis, Universidade de Aveiro, 2018. http://hdl.handle.net/10773/23678.
Full textCardiovascular disease is currently one of the major causes of death in developed countries. Atherosclerosis is one of these diseases and results from an unhealthy lifestyle a ecting predominantly medium size arteries, such as the coronary or the carotid artery. It consists on the deployment of layers of fat in the vessel walls, narrowing the blood vessel and limiting the blood ow. Stents are small expandable devices that, when placed inside the artery, allow it to expand almost to its original form. There are two types of stents: ballon expandable stents and self-expanding stents. Self-expanding stents were the ones studied in this Dissertation and their major di erence relies on the material they were made of. Shape memory alloys have been researched for the past decades due to their unique features. They are known for being able to recover their original form after su ering a large deformation, through the application of a stimulus that can either be magnetic or of temperature. The main goal of this Dissertation was to study the shape memory alloys in order to have a better understanding of their behavior and unique properties, so that it can be applied in numerical simulation software (in this case Femap with NX Nastran). Therefore, it was performed a bending test on two commercially available models. Di erent types of analysis and options provided by the software, as well as three di erent mesh sizes, allowed to take di erent conclusions. It was possible to conclude that, for the theoretically more exible model, the obtained results were similar to the ones used as a reference. Nevertheless, for the other model the results were a bit di erent than the ones expected. It was also noted that the mesh size has noticeable in uences on the results.
As doenças cardiovasculares correspondem atualmente a uma das maiores causas de morte nos países desenvolvidos. A aterosclerose é uma destas doenças e resulta, essencialmente, de um estilo de vida pouco saudável afetando predominantemente as artérias de médio calibre: coronárias, carótidas, renais, entre outras, e consiste no acumulamento de gordura no interior do vaso sanguíneo até este ficar completamente obstruído. Os stents são pequenos dispositivos expansíveis que, uma vez colocados na artéria, expandem permitindo assim que este vaso _que desobstruído. Existem essencialmente dois tipos de stents: os que são expandidos através de um balão e os que expandem automaticamente. Estes últimos foram estudados no âmbito da proposta dissertação, estando a sua grande diferença no material de que são feitos. Os materiais com memória de forma têm sido alvo de pesquisa durante as últimas décadas devido às suas características únicas. Distinguem-se por, após terem sofrido uma deformação elevada, conseguirem recuperar a sua forma original apenas através da aplicação de um estímulo, que pode ser magnético ou de temperatura. O âmbito desta dissertação consistiu em estudar os materiais com memória de forma, de modo a perceber o seu comportamento e as suas propriedades bem como a sua aplicação no software de simulação numérica Femap with NX Nastran. Foram então estudados dois modelos disponíveis comercialmente, através da execução de um teste de flexão. Diferentes tipos de análises e opções do software foram testadas, assim como diferentes malhas para o mesmo modelo. Foi possível concluir que, para o modelo teoricamente mais flexível, os resultados foram semelhantes à referência utilizada, enquanto que para o outro modelo foram encontradas algumas diferenças. De notar ainda a influência do tamanho da malha nos resultados obtidos.
Nicholls, Ursula Joy. "An investigation of a structural phase transition : the R-point instability in KMnF₃." Thesis, University of Edinburgh, 1987. http://hdl.handle.net/1842/15519.
Full textWillshaw, Stephen Kilgour. "On pattern-switching phenomena in complex elastic structures." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/on-patternswitching-phenomena-in-complex-elastic-structures(d013e89e-c413-4612-a1f7-9fc55739cdfb).html.
Full textDe, Felice Valerio Francesco. "Il vortice a superficie libera in quanto instabilità." Toulouse 3, 2008. http://thesesups.ups-tlse.fr/253/.
Full textThe spontaneous genesis of free surface whirlpools represents a traditional hydrodynamic phenomenon of which the causes are not yet completely clarified. The scientists supposed for a long time that the rotation was due to the gradual concentration of the vorticity, coming from the upstream flow, which through a mechanism of convention was accumulated on the axis of the rising whirlpool. One second assumption supposes that the formation is due to an hydrodynamic instability; this possibility has been analyzed in an experimental work and some numerical simulations in the case of an axisymmetric flow. In this work it's shown that, in the presence of non uniform boundary conditions, as the Reynolds number is increased, an instability, which lead to a rotation in the flow, is observed. In the first part of the work is made a linear analysis of stability on the flow in an axisymmetric conditions. Is then considered a flow with non uniform inlet conditions in the azimuthal direction: the least stable eigenvalue (and the associated eigenfunction) of the system is calculated and it's also calculated the Reynolds number at which the flow becomes unstable. In the second part is described the experimental work made at the IMFT on the same geometry and flow. The experimental results agree with the numerical results to confirm the thesis which the swirls can be generated by a phenomenon d' instabilited
Englehart, Michael. "Beyond Family Structure: Examining the Association between Family Instability and Childhood Delinquency." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1462895401.
Full textHochet, Antoine. "Etude des courants océaniques transitoires de grande échelle : structure verticale, interaction avec la topographie et le courant moyen, forçage par instabilité barocline." Thesis, Brest, 2015. http://www.theses.fr/2015BRES0015/document.
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Monnier, Antoine. "Calcul par la méthode asymptotique numérique des instabilités en interaction fluide-structure." Thesis, Lorient, 2018. http://www.theses.fr/2018LORIS484/document.
Full textThis thesis is a first contribution to the bifurcation analysis of fluid flows by taking into account fluid-structure interactions. Instability with fluid-structure interactions appears in many areas of everyday life or industry such as, for example: flag floating in the wind, flow within heat exchangers for energy production, flow around submarine cables for the extraction of raw materials or the fixing of off-shore platforms, flow around aeronautical or naval structures. In these situations, complex vortex-induced vibrations of the structures can occur. The aim of the thesis is to propose an algorithm allowing stability analysis of such systems. Thus, an original coupling of a high order perturbation method (Asymptotic Numerical Method - ANM) to a spatial discretization which takes into account fluid-structure interactions is proposed. For this purpose, a purely Eulerian description of the motion is retained. Fluid-structure interaction is described using an immersed boundary method (IBM) with continuous forcing (penalization method) and discrete (Ghost-Cell method) forcing. The presence of bodies within the flow is obtained by means of the Level-Set method. In addition, a time integrator of the governing equations associating ANM, IBM and homotopy technique is proposed. All these algorithms are applied to analyse incompressible flows, at low Reynolds number, of a Newtonian viscous fluid in the presence of rigid solids (fixed or moving). Bifurcation analysis of flows in a channel with sudden expansion / contraction (stationary bifurcation), or around a cylinder (Hopf bifurcation) are carried out. Transient analysis of a flow around a moving rigid cylinder is also proposed. Our results make it possible to evaluate accuracy and performance of the proposed algorithms. Thus, thesis results allow to conclude on the validity of the proposed approach. Finally, this thesis work constitutes a first step towards flow stability analysis in the presence of complex structures, representative of real situations
PONTE, ELAINE CRISTINA RODRIGUES. "EVALUATION OF REFINED MODELS FOR INSTABILITY AND VIBRATION OF TWO-DIMENSIONAL STRUCTURE." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2007. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=11334@1.
Full textEste trabalho consiste em desenvolver e avaliar modelos clássicos de elementos finitos combinados com funções polinomiais adicionais, para a obtenção de cargas críticas de instabilidade e freqüências naturais de estruturas planas, com seus respectivos modos. O objetivo consiste em buscar uma sistemática confiável para obter estimativas de deformações localizadas em regime próximo ao colapso. Utiliza-se o método dos Elementos Finitos em combinação com o método clássico de Rayleigh-Ritz. Como elemento fundamental para tal estudo, emprega-se o elemento retangular de Barber-Weaver, que contém quatro nós, cada nó com duas translações e duas rotações independentes (equivalentes a uma rotação e uma distorção angular). Esse elemento é enriquecido com funções de deslocamentos adicionais internas e de contorno, em forma de séries polinomiais gerais. Esse conjunto de funções é incorporado nas expressões de energia para levar ao estabelecimento de matrizes de rigidez elástica, geométrica e de massa. Tais matrizes permitem estabelecer problemas generalizados de autovalor para obtenção de cargas críticas e freqüências, e respectivos modos de flambagem e vibração. Para os estudos numéricos comparativos apresentados nos exemplos, são implementadas diversas rotinas usando o software Maple 9.0. Os resultados mostram que a metodologia apresentada pode ser usada no desenvolvimento de uma técnica aplicável à obtenção de modos globais e localizados de instabilidade, quando há a combinação de efeitos não lineares geométricos e de material.
This work consists in developing and evaluating classical of finite element models combined with additional polynomial functions, to obtain critical loads of instability and natural frequencies of plane structures, and respective modes. The objective is to search for a reliable technique to get estimates of localized deformations near to collapse. The Finite Elements method is used in combination with the classic method of Rayleigh-Ritz. As a basic element for such study, the rectangular element of Barber-Weaver is used, containing four nodes, each one with two translations and two independent rotations (equivalents to a rotation and an angular distortion). This element is enriched with additional internal displacement functions and with functions on the boundary, forming general polynomial series. These nodal functions are incorporated in the energy expressions leading to the establishment of elastic stiffness, geometric, and mass matrices. Such matrices allow the establishment of generalized eigenvalue problems to obtain critical loads and frequencies, and the respective modes of buckling and vibration. For the comparative numerical studies presented in the examples, several routines are implemented using software Maple 9.0. The results show that the methodology presented herein can be used in the development of an applicable technique to the ascertainment of instability in global and located modes, when there is a combination of geometric nonlinear and material effects.
Boteva, Lora. "Investigating transcription, replication and chromatin structure in determining common fragile site instability." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28803.
Full textBoutillier, Benoît. "Instabilités nivologiques : interaction entre un manteau neigeux et une structure paravalanche souple." Grenoble INPG, 2004. http://www.theses.fr/2004INPG0131.
Full textThis phd thesis deals with the design of snow net systems and improving the prediction of the forces to which these structures are submitted. In this case, only the slow snow movements due to gravity were taken into account. The study was divided into two parts. First, the interaction between the snowpack and the snow net system was described in 2d based on the finite element method. The mechanical behaviour of the snow is represented by the gagliardini and meyssonnier model (lgge, 1997). The structure, is taken into account by mixed boundary conditions linking reactions applied on the downhill nodes of the snowpack to their displacements. This approach allowed to verify that, for the load applied on the cable, the gravity component normal to the slope could be neglected in comparison with the component parallel to the slope. Secondly, this result opened up a new discrete element based approach in which the snowpack is described by a set of parallelepiped elements sliding relatively to each other along the main slope. The lgge model and non-linear maxwell type models are used for describing the mechanical behaviour of the snow. The penetration of the snowpack could also be simulated by this description. This approach was first developed in a two-dimensional case, and then extended to a three-dimensional one. In parallel with these simulations, a large experimental campaign was performed on real structures located in flaine (hte savoie, france). The measurement of forces applied on the structure’s anchors, completed by a steady characterization of the snowpack, allowed to obtain the first elements of comparison, which tend to support the validity of the model
Uzawa, Ken. "Study of modulational instability and structure of zonal flows in fusion plasmas." Kyoto University, 2008. http://hdl.handle.net/2433/135587.
Full text0048
新制・課程博士
博士(エネルギー科学)
甲第13952号
エネ博第173号
新制||エネ||40(附属図書館)
UT51-2008-C868
京都大学大学院エネルギー科学研究科エネルギー基礎科学専攻
(主査)教授 岸本 泰明, 教授 近藤 克己, 教授 福山 淳
学位規則第4条第1項該当
PANINE, PIERRE. "Membranes polymères asymétriques : instabilité diffusionnelle et initiation des macrovides." Université Joseph Fourier (Grenoble), 1998. http://www.theses.fr/1998GRE10010.
Full textPessah-Simonetti, Muriel. "Effets des instabilites structurales sur les proprietes mecaniques du superalliage monocristallin mc2." Paris 11, 1994. http://www.theses.fr/1994PA112474.
Full textWiplier, Olivier. "Étude numérique des instabilités d'un écoulement de couche limite en présence d'une paroi déformable." Lille 1, 1999. https://pepite-depot.univ-lille.fr/LIBRE/Th_Num/1999/50376-1999-297.pdf.
Full textEn effet, mis à part l'onde de Tollmien-Schlichting, d'autres sources d'instabilités issues de l'interaction apparaissent. La résolution du système complet de Navier-Stokes couple au modèle dynamique de la paroi a permis ensuite de simuler simultanément ces sources d'instabilités et leurs interactions. La prise en compte de parois souples de longueurs finies a notamment permis de mettre en évidence des ondes progressives se propageant vers l'amont ou des déformées globales de la surface (induites par les non-linéarités). La recherche d'une instabilité absolue dans le système a été menée de manière systématique, à la fois par une étude linéaire de l'instabilité et par l'injection d'un signal impulsionnel dans le système global fluide-structure. Bien qu'il soit effectivement possible de réduire l'amplification de l'instabilité visqueuse par utilisation de parois souples, la paroi elle-même généré des ondes dont l'interaction avec celle du fluide peut conduire dans certains cas à une détérioration de la paroi par l'apparition possible d'un mécanisme d'instabilité absolue
Chatellier, Ludovic. "Modelisation et contrôle actif des instabilités aéroacoustiques en cavité sous écoulement affleurant." Poitiers, 2002. http://www.theses.fr/2002POIT2285.
Full textThis thesis includes modelization, experimental investigations and active control of the aeroacoustics of cavities under low mach number turbulent flows. A progressive formulation for the stability analysis of the fluid interface separating two uniform flows is first presented. The oscillation stages show dependance to the geometric configuration and to the Mach number. An experimental model of adjustable dimensions is then investigated using pressure measurements. The extensive resulting data partially validate the chosen theoretical analysis. A vibrating apparatus is designed and applied to the active control of the aeroacoustic stages with focus on the fluid-resonant conditions. Proof is given that this system leads to a deterministic modulation of the coupling intensity. Finally, a Particle Image Velocimetry system is synchronized with chosen oscillation stages in order to aerodynamically validate the theoretical approach and the active control efficiency
Caburet, Sandrine. "Structure mosai͏̈que et instabilité de l'ADN ribosomal humain : implications dans la sénescence et la cancérogenèse." Paris 7, 2002. http://www.theses.fr/2002PA077038.
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