Relevant bibliographies by topics / Institute of Organic Chemistry and Biochemistry

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Institute of Organic Chemistry and Biochemistry'

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Published: 4 June 2021
Last updated: 8 February 2022

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Journal articles on the topic "Institute of Organic Chemistry and Biochemistry"

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Mlinac-Jerković, Kristina, Vladimir Damjanović, Svjetlana Kalanj-Bognar, and Jasna Lovrić. "Marking a Century of the Department of Chemistry and Biochemistry at School of Medicine in Zagreb." Croatica chemica acta 92, no. 3 (2019): 435–42. http://dx.doi.org/10.5562/cca3554.

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In 2018 the Department of Chemistry and Biochemistry at Zagreb School of Medicine celebrated 100 years since it was established by professor Fran Bubanović. This essay is focused on his successors, outstanding teachers and scientists, professors Tomislav Pinter and Mihovil Proštenik, members of Yugoslavian (today Croatian) Academy of Sciences and Arts. Tomislav Pinter was a prominent physical chemist who had an original approach and gave novel interpretation of van der Waals and Wohl’s equations. He also served as the president of Croatian Chemical Society. Neurobiochemist Mihovil Proštenik started as an organic chemist at “Prelog’s Zagreb School of Organic Chemistry”. He collaborated with two Croatian Nobel prize winners in chemistry: his PhD thesis supervisor Vladimir Prelog and Lavoslav Ružička. He was the founder of “Zagreb School of Lipidology”, discovered a new sphingoid base C20-sphingosine, and had a major role in the establishment of Ruđer Bošković Institute. Herein we honor their contributions to Croatian science and beyond, and share so far unpublished valuable material from the Department archive.
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Spichenkova, N. E., and V. E. Vaskovsky. "Bioorganic chemistry: Institutes, journals, publications, a short scientific metric analysis on the 50th anniversary of the Institute of Natural Compound Chemistry, Institute of Bioorganic Chemistry." Russian Journal of Bioorganic Chemistry 35, no. 2 (March 2009): 258–67. http://dx.doi.org/10.1134/s1068162009020162.

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Buchanan, J. Grant. "Sir James Baddiley. 15 May 1918 — 19 November 2008." Biographical Memoirs of Fellows of the Royal Society 56 (January 2010): 3–23. http://dx.doi.org/10.1098/rsbm.2010.0010.

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James Baddiley was a biochemist who used the methods and insight of the organic chemist to answer important questions in biology, notably coenzyme structure and the structure and function of bacterial cell walls. A graduate of Manchester University, he moved to Cambridge in 1944 with A. R. Todd, where he synthesized adenosine triphosphate, the nucleotide concerned with essential energy transformations in all forms of life. As an independent researcher at the Lister Institute in London he elucidated the structure of coenzyme A and other coenzymes. He was appointed Professor of Organic Chemistry in Newcastle, where the exploration of the structures of two cytidine nucleotides led to the discovery of the teichoic acids, major components of the cell walls and membranes of Gram-positive bacteria. These discoveries were extended to cover the structures, biosynthesis, function and immunology of the teichoic acids. Baddiley became Professor of Chemical Microbiology in 1977. Moving to Cambridge after his retirement, he was able to continue his researches in the Department of Biochemistry. He was elected a Fellow of Pembroke College and as an elder statesman undertook extensive committee work, often as chairman, both in Cambridge University and nationally. He was knighted in 1977.
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Zhang, Youshang. "Insulin research in China and the U.K." Biochemical Society Transactions 39, no. 5 (September 21, 2011): 1323–26. http://dx.doi.org/10.1042/bst0391323.

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Insulin has been extensively studied since it was discovered by Banting and Best in 1921. Early in 1934, Dorothy Crowfoot and John Desmond Bernal obtained the first X-ray diffraction photograph of an enzyme protein: pepsin. In 1935, they took another photograph of a protein hormone: insulin. The chemical structure of protein was unknown until the amino acid sequence of bovine insulin was solved by Fred Sanger and colleagues in 1955. In 1958, the chemical synthesis of bovine insulin started in China through a nationwide collaboration of three institutions: the Institute of Biochemistry in Shanghai, the Institute of Organic Chemistry in Shanghai and Beijing University. The total synthesis of bovine insulin in crystalline form was accomplished in 1965. The success of the synthesis of the first protein in vitro greatly encouraged young researchers in China. Not long afterwards, the project of structural analysis of insulin crystal was carried out in China through the collaboration of the Institute of Biophysics, the Institute of Physics and Beijing University, and succeeded in 1971. In Dorothy Hodgkin's laboratory in Oxford, X-ray diffraction studies of insulin crystals were resumed after about 30 years, and the structure of rhombohedral insulin crystal was solved in 1969. Through insulin research, the Institute of Biophysics in Beijing and the Institute of Biochemistry in Shanghai established scientific collaboration and personal friendship with Dorothy Hodgkin's laboratory in Oxford, and later Guy Dodson's laboratory in York and Tom Blundell's laboratory in London. In 1975, Dorothy Hodgkin wrote a short note, ‘Chinese work on insulin’ in Nature, anticipating closer scientific exchange between the East and the West. In 1982, a bilateral meeting between the Biochemical Societies in the U.K. and China was held in Oxford. Now, the second bilateral meeting held in Shanghai will further promote the collaboration between our two countries.
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Kawaguchi, Kichitaro, and Tatsuya Yamagata. "Drs. Sadako and Yasuo Inoue Move to the Institute of Biological Chemistry, Academia Sinica, Taiwan, R. O. C." Trends in Glycoscience and Glycotechnology 8, no. 40 (1996): 143–46. http://dx.doi.org/10.4052/tigg.8.143.

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Wilson, Brice A. P., Christopher C. Thornburg, Curtis J. Henrich, Tanja Grkovic, and Barry R. O'Keefe. "Creating and screening natural product libraries." Natural Product Reports 37, no. 7 (2020): 893–918. http://dx.doi.org/10.1039/c9np00068b.

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Wu, Yanqi, Yuehua Wan, and Fengzhi Zhang. "Characteristics and Trends of C-H Activation Research: A Review of Literature." Current Organic Synthesis 15, no. 6 (August 29, 2018): 781–92. http://dx.doi.org/10.2174/1570179415666180426115417.

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Background: C-H activation has attracted great interests over the past two decades, which resulted in an explosive growth in both quality and quantity of published papers related to this topic. Objective: In this review, a bibliometric analysis was performed to evaluate the publications in this field from 1996 to 2015 based on the Science Citation Index (SCI) Expanded database. This work presented a detailed overview of C-H activation from aspects of types of articles, citations, h-indices, languages, years, journals, institutions, countries and author keywords. Conclusion: The results showed that the USA took the leading position in this research field, followed by P. R. China and German. Chinese Academy of Science had the most publications and the highest h-index, Scripps Research Institute won the first place as far as the highest average citation per paper is concerned. Organometallics, Angewandte Chemie International Edition and Journal of the American Chemical Society were the most productive journals in this field, and Chemistry was the most frequently used subject category. Keywords analysis indicated that most research focused on the Palladium, Rhodium and Copper catalyzed cross-coupling synthetic method development for the heterocycle synthesis. The research about exploring the asymmetric C-H functionalization, mechanism investigation and solving the regioselectivity issue is the development trend in this area.
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Tressaud, Alain. "The laureate of the International Moissan Prize 2009 is Herbert W. Roesky, Professor of Chemistry at the Institute for Inorganic Chemistry, Gottingen University, Germany." Journal of Fluorine Chemistry 131, no. 3 (March 2010): 295. http://dx.doi.org/10.1016/j.jfluchem.2009.11.016.

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Conboy, Darren, and Fawaz Aldabbagh. "6-Imino-1,2,3,4,8,9,10,11-octahydropyrido[1,2-a]pyrido[1′,2′:1,2]imidazo[4,5-f]benzimidazole-13-one: Synthesis and Cytotoxicity Evaluation." Molbank 2020, no. 1 (March 5, 2020): M1118. http://dx.doi.org/10.3390/m1118.

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The first report of an iminoquinone of imidazo[4,5-f]benzimidazole is described. The 2D-NOESY spectrum of 1,2,3,4,8,9,10,11-octahydropyrido[1,2-a]pyrido[1’,2’:1,2]imidazo[4,5-f]benzimidazol-6-amine was used to confirm the location of the imine moiety at the C-6 position of the title compound. Cytotoxicity data from the National Cancer Institute are included.
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Djoussé, Luc, Richard H. Myers, Hilary Coon, Donna K. Arnett, Michael A. Province, and R. Curtis Ellison. "Smoking influences the association between apolipoprotein E and lipids: The national heart, lung, and blood institute family heart study." Lipids 35, no. 8 (August 2000): 827–31. http://dx.doi.org/10.1007/s11745-000-0591-1.

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Dissertations / Theses on the topic "Institute of Organic Chemistry and Biochemistry"

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Easton, Christopher J. "Aspects of biological and organic chemistry, particularly amino acid, cyclodextrin, and free radical chemistry /." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09S.D/09s.de13.pdf.

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Ding, Xiao Dong. "Synthesis and characterization of heme models and spectroelectrochemical studies of heme proteins." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/282523.

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To better understand the relationship between the structure and electronic properties of the iron center and the functions of heme proteins, both naturally occurring heme proteins and synthetically prepared heme models have been studied. The reduction potential (E°') and the pH dependence of E°' of nitrophorin 1 (NP1) and myoglobin (Mb) were determined by spectroelectrochemical techniques. The difference in the electrostatic interaction of the Fe(III) center with buried charged groups in the heme pocket of Mb and NP1 is the major factor that causes the 300 mV difference in E°. The pH dependence of the E°' determined between pH 5.5 and 7.5 is small for both Mb and NP1 because they have the same axial ligands. Three meso-ortho-phenyl substituted porphyrins, (o-F), (o-CF₃) and (2,6-Cl₂)(p-OCH₃)₃TPP and one meso-para-phenyl substituted porphyrin, (p-OCH₃)₄TPP, were synthesized as models of cytochrome b₅ . Cyclic voltammetry was used to measure their reduction potentials. The overall formation constants, logβ₂III and logβ₂II, have been calculated based on the reduction potentials of the iron(III)/(II) couple as a function of N-methylimidazole concentration. The values of logβ₂III are in the order of o-F > o-CF₃ > p-OCH₃ ≈ 2,6-Cl₂, indicating that the electron-donating ability is in the order of o-F < o-CF₃ < p-OCH₃ ≈ 2,6-Cl₂. The overlap and direct transfer of electron density from the halogen to the iron in the product reduces the Lewis acidity of iron(III), resulting in decreased logβ₂III. The order of logβ₂II for N-methylimidazole complexed Fe(II) porphyrinates is similar to that of the Fe(III) complexes, indicating no major difference in the Lewis acidity of Fe(II) as compared to Fe(III). Basket handle porphyrinates with covalently bound methionine and aliphatic amine model ligands (RCH₂SCH₃, RCH₂SCH₃ and RNH₂, RNH₂) were chosen as precusor of cytochrome c and f. The Fe(III) complexes were to be prepared and investigated by electrochemical and spectroscopic techniques. The precursor porphyrin was synthesized. Several schemes were investigated for the synthesis of the handles having methylthioether and aliphatic amine without success, and it was decided not to continue this project. Therefore, no final basket handle porphyrin was available for further characterization.
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Sua, Andy. "Using Metal-Organic Framework Film as a Drug-Eluting Stent Coating." Thesis, California State University, Long Beach, 2019. http://pqdtopen.proquest.com/#viewpdf?dispub=10975741.

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Metal-organic frameworks have a wide range of applications including gas separation, gas capture, catalysis and drug delivery. Due to the in-stent thrombosis of the current drug-eluting stents we propose replacing the toxic polymer with a more biodegradable MOF thin film consisting of MIL-88b. The MIL-88b thin film was formed on functionalized gold through a direct crystallization method and was confirmed using x-ray diffraction (XRD) and Fourier- transform infrared spectroscopy (FTIR). Possible ibuprofen encapsulation and elution was confirmed through FTIR and UV-VIS spectroscopy. The MIL-88b thin film was also formed on medical grade stainless steel to mimic conditions of the current DES. The surface area, using N2 gas isotherm at 770K, of MIL-88b and MIL-53 was compared to validate the favorable porosity for drug delivery application.

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Agha, Kazim Ally. "Synthesis, physicochemical and biochemical properties of C3'-modified 2',5'-linked oligonucleotides." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84457.

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Oligoribonucleotides comprising of 2',5' -linked internucleotide linkages are known to bind selectively to RNA over DNA. The ability to bind to RNA renders them suitable as probes for many biological applications, such as 'antisense technology'. Little is known about the effect of sugar structure (and conformation) on the binding properties of 2',5'-linked oligonucleotides. To get insight into the role of sugar conformation, 2 ',5'-linked oligonucleotides modified at the C3'-position of the furanose ring were synthesized via solid phase synthesis and their binding to complementary single stranded DNA and RNA was studied. Their application as antisense oligonucleotides was also evaluated.
The first analogue studied was the C3'-epimer of 2',5'-linked ribonucleic acids (2 ',5'-RNA), that is, an oligonucleotide in which the ribofuranose sugar is replaced by xylofuranose (2' ,5'-XNA). This was followed by the synthesis and analysis of the C3'-fluorinated xylofuranose analogue (2',5'-FXNA). The sugar conformation in these oligonucleotides are believed to have a very high population of the C3'-endo ('extended') conformation. Consistent with this notion, CD structural studies indicated that 2 ',5,'-linked XNA and FXNA show structural similarities to the 'extended' C2'- endo form of DNA. We found that both 2',5 '-XNA and 2',5'-FXNA bound weakly to complementary single stranded DNA and RNA. Neither of the xylooligomers resulted in RNaseH activated degradation of RNA.
The last modified oligonucleotide to be studied was the C3' -fluorinated-2',5'-linked ribonucleic acids (2',5'-FRNA), which has a compact C2'-endo sugar conformation. In contrast to 2',5'-FXNA, 2 ',5'-FRNA bound strongly to complementary oligonucleotides and showed structural similarities to RNA (CD spectroscopy). Our studies showed that it did not cause RNaseH based degradation of RNA.
These studies are consistent with the notion that the effect of sugar conformation in 2',5'-oligonucleotides is opposite to that of 3',5'-oligonucleotides. In other words, a C3'-endo sugar conformation in 2',5'-oligomers renders the oligonucleotide as 'extended' and portrays itself equivalent to the 'extended' DNA conformation (which has C2'-endo conformation), whereas a C2'-endo 2 ',5'-oligonucleotide adopts a 'compact' conformation that is equivalent to that seen in 3',5 '-oligonucleotides adopting the C3'- endo pucker (e.g. RNA).
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Morley, Krista Louise. "Focusing mutagenesis into the active site to improve hydrolase selectivity." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111830.

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Occasionally, researchers need to modify enzymes through amino acid substitutions to make them more efficient catalysts for organic synthesis. There is still debate over the best protein engineering strategy for improving enzyme enantioselectivity: rational design or directed evolution. Rational design experiments focus mutations close to the active site, while directed evolution experiments often find mutations far from the active site.
In this thesis, a combination of the two strategies improved Pseudomonas fluorescens esterase (PFE) for production of a useful synthetic building block for organic synthesis. Random mutagenesis within the active site increased enantioselectivity more effectively (up to 5-fold reaching E = 61) than random mutagenesis of the entire protein (only 1.5-fold reaching E = 19). A general survey of previously published enzyme improvements showed that closer mutations were more effective than distant mutations for improving enantioselectivity. On this basis, we proposed that random mutagenesis focused in the active site may dramatically increase the success rate in future directed evolution experiments. The X-ray crystal structures of three improved PFE mutants showed that mutations directly in the active site can increase enantioselectivity without significantly altering the shape of the binding pocket. For rationalizing the improved enantioselectivity, a crystal structure of a transition state analogue-complex provided the conformation of the fast reacting enantiomer and computer modeling determined the conformation of the slow reacting enantiomer.
When novel esterases are discovered from directed evolution experiments, they are screened with libraries of esters to identify their preferred substrates. A convenient method for the parallel synthesis of esters was developed by using solid-supported reagents to eliminate traditional purification.
Acetyl xylan esterase (AxeA) was examined as a potential catalyst for the production of chitosan, a biopolymer with many commercial applications. Screening for chitin deacetylase activity showed that AxeA preferentially deacetylates chitosan oligosaccharides over alkali-treated chitin and crystalline chitin.
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Roman, Miguel Angel. "Synthesis of branched nucleosides and oligonucleotides containing flexible alkylamine linkers on the heterocyclic bases." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22797.

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The N3 position of thymidine was alkylated with different sized bromoalkyl phthalimide linkers in generally good yields, with no alkylation observed on the sugar ring. The free amino group, available after methylamine deprotection of the phthalimide linker, was protected with the levulinyl protecting group (e.g., 20). Branched 'Y'-shaped nucleic acids containing branching monomer 20 were synthesized using standard solid phase synthetic methodology and complexes of these branched nucleic acids with one and two mole-equivalents of linear complement dA$ sb{10}$ are investigated by thermal melting. At the branching point the levulinic amide exhibited poor lability to Letsinger's hydrazine solution and proved to be incompatible with the solid phase synthesis of branched nucleic acids. The primary amino group provided a handle which was used to extend the size of the linker incorporating a primary hydroxyl group at the site of levulinic protection (e.g., 37, 38). The levulinic ester showed much better lability to hydrazinolysis rendering it more compatible with the solid phase synthesis of branched nucleic acids. An extensive one and two dimensional NMR characterization of the functionalized nucleosides is reported.
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Park, Seongsoon. "Enhancing hydrolase activity and selectivity by medium, substrate, and protein engineering." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=83088.

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Researchers use enzymes for enantio- and regioselective reactions because of their high selectivity and activity toward natural substrates. However, researchers sometimes need to modify the reaction system or the enzyme itself to get reliable selectivity and activity when they deal with unnatural substrates. To obtain researcher's need, one can change the solvent, modify the substrates, or alter the enzyme itself. These processes are called medium, substrate, and protein engineering, respectively.
This thesis deals with hydrolases, which are classified by EC 3. We applied the proper approach to improve their activity and selectivity depending on the reactions. For the first approach, highly polar ionic liquids were applied to lipase-catalyzed acylation. Ionic liquids worked reliably in enantio- and regioselective lipase-catalyzed reactions. In particular, ionic liquids dissolved polar substrates such as glucose and L-ascorbic acid, thereby facilitating their acylations. In the second approach to improving enantioselectivity of CAL-B (Candida antarctica lipase B) in beta-lactam ring opening reactions, we changed the nucleophile from water to a range of alcohols. Longer, secondary alcohols increased the reaction rate as well as the enantioselectivity. Molecular modeling revealed that the high enantioselectivity of CAL-B and the critical role of alcohols. For the last approach, structure-guided random mutagenesis was applied to increase the enantioselectivity of PFE ( Pseudomonas fluorescens esterase) toward MBMP (methyl 3-bromo-2-methylpropionate). The homology model was used to select amino acid residues for mutagenesis near the stereocenter of the docked tetrahedral intermediate of the substrate. Randomization of these residues yielded a Val122Ser mutant with E increased to 61 (from 12 of wild type enzyme), as well as a Val122Met mutant to 36.
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Zhou, Wen-Qiang. "The synthesis of amide-linked 2',3'-cyclopropanated dinucleosides and the effect of their incorporation into DNA-strands on duplexation." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40024.

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In order to establish if binding affinity could be improved by conformationally restricting the amide backbone, exo-amide-linked and endo-amide-linked 2$ sp prime$,3$ sp prime$-cyclopropanated dinucleoside analogs (e.g. dimers 35, 54, and 55) have been studied. The dimers were synthesized by coupling the corresponding cyclopropyl acids (5$ sp prime$-end building unit) with aminothymidines (3$ sp prime$-end building unit) by standard peptide synthesis methodology. After proper functionalizations, the dimers were incorporated into DNA sequences, and the effects of their incorporation into DNA-strands on binding to complementary DNA and RNA were evaluated.
Different strategies were explored to prepare the carboxylic acid-functionalized 2$ sp prime,3 sp prime$-cyclopropanated nucleoside analogs as the 5$ sp prime$-end building block. It was found that reaction of the $ alpha, beta$-unsaturated selenonyl uridine with the anions of 2-substituted acetates could efficiently yield the ester-functionalized cyclopropanes (e.g. 32 and 49) in a stereoselective manner, through a Michael-type cyclopropanation mechanism. Proper transformations of the ester precursor successfully provided the desired acid derivatives (e.g. 33, 52 and 53).
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Mangos, Maria M. "Factors governing the design, selection and cleavage of sugar-modified duplexes by ribonuclease H." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85579.

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The antisense principle bases its premise in the exquisite complementarity of a synthetic, chemically-modified oligonucleotide to tightly bind with a unique target RNA sequence. Rapid and selective genetic discrimination, as driven by the formation of multiple points of target contact, constitutes a central goal of oligonucleotide therapies. Most synthetic designs have, however, provided little structural insight on the role of the antisense oligonucleotide (AON) in triggering RNA cleavage of preformed hybrids, as catalyzed by a ubiquitous, intracellular enzyme known as ribonuclease H. The use of RNase H to assist AON inhibition of gene expression is crucial to mainstream antisense technologies, yet the precise mode by which this enzyme acts on AON/RNA duplexes remains unclear.
To address the role of substrate structure on enzyme activation, a dominant theme of this thesis highlights the design, synthesis and structural studies of novel AONs comprised of rigid 2'-deoxy-2'-fluoroarabino (2'F-ANA) or native (DNA) nucleotides, containing interspersed flexible (e.g. "2',3'-seconucleotides") or anucleosidic (e.g. butyl) residues. This unique AON class combines both pre-organization & flexibility within the hosting heteroduplex, which on their own usually prove detrimental towards enzyme trigger. Their combination, however, synergistically activates both E. coli and human RNases H, leading to potent destruction of duplexed RNA. These compounds thus represent the first examples of modified AONs lacking deoxyribose sugars that elicit RNase H activity comparably to the native (DNA) systems. DNA-derived AONs with acyclic residues also amplify enzyme-catalyzed target degradation, suggesting the added flexibility imparted to the substrate structure to be vital for ameliorating the protein/nucleic acid interaction. Melting and circular dichroic experiments have revealed that the enhanced dynamics associated with a particular acyclic modification remain globally undetectable, indicating the acyclic residues induce only local structural deformations to the helix architecture.
Intricate comparisons of the structural and biological properties of various acyclic residues (e.g. butyl, propyl and ethyl interresidue spacers) designed to locally compress or expand the AON helix backbone at a defined axial site has enabled a deeper understanding of the conformational factors that underlie the observed enhancements.
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Kutterer, Kristina M. K. "Urea and carbamate backbone modified DNA & work towards a synthesis of polyoxin L and analogues." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28808.

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Urea, N-methylurea and carbamate linked thymidine dimers, 38, 37 and 39 respectively, were synthesized efficiently and incorporated into 12- and 19-mer DNA oligonucleotide strands, via solid-phase synthesis. Thermal denaturation studies utilizing complementary single stranded DNA, RNA and duplex DNA, indicated selectivity of binding of all three backbone modified oligomers to single stranded DNA. The oligomer containing dimer 37 exhibited the strongest binding to single stranded DNA. Carbamate and 5$ sp prime$-N-methylurea modified dimers suitable for the preparation of longer nucleoside homopolymers were efficiently prepared from either thymidine or 3$ sp prime$-azido-3$ sp prime$-deoxythymidine.
Three efficient syntheses of precursors (7, 33, 36) of carbamoylpolyoxamic acid starting from L-arabinose were developed. Utilizing uridine as the starting material, an expedient synthesis of a precursor (44) to the nucleoside moiety of polyoxin L was also achieved. The conversion of cyanides to carboxylic acids was extensively investigated.
Protected polyoxamic acid 17 was synthesized in 11 steps from L-arabinose.* ftn*Please refer to the dissertation for diagrams.
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Books on the topic "Institute of Organic Chemistry and Biochemistry"

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General organic & biochemistry. [Belmont, CA]: Thomson Brooks/Cole, 2007.

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P, Rogers Elizabeth, ed. General, organic, and biochemistry. 3rd ed. Monterey, Calif: Brooks/Cole Pub. Co., 1987.

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Bettelheim, Frederick A. Introduction to organic & biochemistry. 4th ed. Fort Worth: Saunders College Pub, 2001.

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Denniston, K. J. General, organic, and biochemistry. 7th ed. Dubuque, IA: McGraw-Hill, 2011.

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J, Topping Joseph, and Caret Robert L. 1947-, eds. General, organic, and biochemistry. 6th ed. Dubuque, IA: McGraw-Hill, 2008.

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J, Topping Joseph, and Caret Robert L. 1947-, eds. General, organic, and biochemistry. 4th ed. Boston: McGraw-Hill Higher Education, 2004.

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J, Topping Joseph, Woodrum Kim 1963-, and Caret Robert L. 1947-, eds. General, organic, and biochemistry. New York, NY: McGraw-Hill Companies, 2014.

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Denniston, K. J. General, organic, and biochemistry. 7th ed. Dubuque, IA: McGraw-Hill, 2011.

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1929-, March Jerry, ed. Introduction to organic & biochemistry. 3rd ed. Fort Worth: Saunders College Pub., 1998.

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Bettelheim, Frederick A. Introduction to organic & biochemistry. 2nd ed. Fort Worth: Saunders College Pub., 1995.

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Book chapters on the topic "Institute of Organic Chemistry and Biochemistry"

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Noble, W. J. "Organic Synthesis at High Pressure." In High Pressure Chemistry and Biochemistry, 295–310. Dordrecht: Springer Netherlands, 1987. http://dx.doi.org/10.1007/978-94-009-3827-4_12.

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Gupta, M. N. "Enzyme function in organic solvents." In Interface between Chemistry and Biochemistry, 49–65. Basel: Birkhäuser Basel, 1995. http://dx.doi.org/10.1007/978-3-0348-9061-8_3.

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Noble, W. J. "Kinetics of Organic Reactions at High Pressure." In High Pressure Chemistry and Biochemistry, 279–93. Dordrecht: Springer Netherlands, 1987. http://dx.doi.org/10.1007/978-94-009-3827-4_11.

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Heimbach, Paul, and Tamás Bartik. "Information from Alternatives in Biochemistry." In Reactivity and Structure Concepts in Organic Chemistry, 165–74. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-83806-4_9.

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Jenner, G. "The Future of High Pressure Organic Synthesis." In High Pressure Chemistry, Biochemistry and Materials Science, 367–92. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1699-2_19.

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Kirby, Anthony J. "The Organic Chemistry of Phosphate Transfer." In Ciba Foundation Symposium 57 - Phosphorus in the Enviroment: Its Chemistry and Biochemistry, 117–37. Chichester, UK: John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470720387.ch7.

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Chuchvalec, Pavel, Kvetoslav Ruzicka, Stanislav Labik, and Vlastimil Ruzicka. "Physico-Chemical Property Data Bank of the Prague Institute of Chemical Technology." In Physical Property Prediction in Organic Chemistry, 89–94. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-74140-1_8.

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Jenner, G. "High Pressure Kinetic Effects as Mechanistic Probes in Organic Chemistry." In High Pressure Chemistry, Biochemistry and Materials Science, 345–66. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1699-2_18.

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Paz, Y., and R. Naaman. "Mode Specifity in Collisions of Aniline with Surfaces covered with Organized Organic Monolayers." In The Jerusalem Symposia on Quantum Chemistry and Biochemistry, 429–41. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-2642-7_30.

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Goddard, William A. "Superconductors: Cuprate High Tc and BEDT-TTF Organic Superconductors." In Computational Materials, Chemistry, and Biochemistry: From Bold Initiatives to the Last Mile, 1203–15. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-18778-1_61.

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Conference papers on the topic "Institute of Organic Chemistry and Biochemistry"

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Москалев, Владимир Борисович. "PREDICTION OF THE CONDITIONS OF CHEMICAL ORGANIC REACTIONS USING THE EDGE ATTENTION GRAPH CONVOLUTION NETWORK." In Наука. Исследования. Практика: сборник избранных статей по материалам Международной научной конференции (Санкт-Петербург, Апрель 2020). Crossref, 2020. http://dx.doi.org/10.37539/srp290.2020.84.35.019.

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Моделирование структуры химической реактивности с точки зрения структуры участвующих веществ имеет важные последствия во всех областях химии и биохимии, от синтеза до понимания метаболических процессов. Для предсказания условий реакций органической химии на основе графов была взята модель графовой сверточной нейронной сети с механизмом внимания на ребрах Edge Attention Graph Convolution Network. Modeling the structure of chemical reactivity from the point of view of the structure of the substances involved has important consequences in all areas of chemistry and biochemistry, from synthesis to understanding metabolic processes. To predict the reaction conditions of organic chemistry based on graphs, we used the model Edge Attention Graph Convolution Network.
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Porto, Caio M., and Nelson H. Morgon. "Quantum Tunneling and Reaction Rates in Selenoxides and Sulfoxides Elimination." In VIII Simpósio de Estrutura Eletrônica e Dinâmica Molecular. Universidade de Brasília, 2020. http://dx.doi.org/10.21826/viiiseedmol202062.

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Selenoxides and sulfoxides elimination reactions are important, not only to Organic Chemistry synthesis, but also to other areas, as Biochemistry. These reactions were studied, using direct dynamics calculations, at the canonical variational theory (CVT) and small curvature tunneling (SCT) level. The calculated rate constants for the selenoxide reaction were in good agreement with experimental data, 8.83 × 10-5 s -1 and 3.20 × 10-5 s -1 , respectively. The rate constants for the sulfoxide reaction are very small at 37°C, namely 2.43 × 10-9 , and there is also a significant tunneling correction, which shows quantum tunneling effects occur in both reactions, although with very different magnitudes. One of the most striking difference comes from the barrier height, which is almost 2000 cm-1 bigger for the sulfoxide elimination, and helps to explain the difference in reaction rates.
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Трофимов, Б., B. Trofimov, Н. Гусарова, and N. Gusarova. "The development of original methodologies of directed synthesis of le-Carbs their analogs and precursors base donacetylene and its derivatives." In Topical issues of translational medicine: a collection of articles dedicated to the 5th anniversary of the day The creation of a department for biomedical research and technology of the Irkutsk Scientific Center Siberian Branch of RAS. Москва: INFRA-M Academic Publishing LLC., 2017. http://dx.doi.org/10.12737/conferencearticle_58be81ec92d17.

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New reactions, which have been discovered and continue to be developed in A.E. Favorsky Irkutsk institute of chemistry SB RAS on the basis of acetylene, a product of oil, gas and coal processing and multi-faceted building block for organic synthesis, have been considered. These reactions provide for the shortest routes to construction of fundamental heterocyclic scaffolds (pyrroles, imidazoles, pyrazoles, indoles, pyridines, dihydropyridines, etc.) with desirable and optimum combination of functional pharmacophoric groups and fragments, which are responsible for antiviral (HIV, flu), antitumor, tuberculostatic and hypotensive activities.
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Braehler, Georg, Ronald Rieck, V. A. Avramenko, V. I. Sergienko, and E. A. Antonov. "Nuclide Separation by Hydrothermal Treatment and Ion Exchange: A Highly Effective Method for Treatment of Liquid Effluents." In ASME 2011 14th International Conference on Environmental Remediation and Radioactive Waste Management. ASMEDC, 2011. http://dx.doi.org/10.1115/icem2011-59217.

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Liquid low level radioactive effluents, when solidified in e. g. cement matrix, contribute to a significant extent to the waste amount to be disposed of in final repositories. Accordingly, since many years scientists and engineers investigate processes to remove the radioactive nuclides selectively from the effluents, to split the raw solution into two separate fractions: a large fraction with activity concentrations below the limits for free release; and a small fraction, containing the activity in concentrated form on e. g. ion exchanger materials (ion exchange has proven to be the most promising method for such “nuclide separation”). The challenge to be taken up is: When (and this is most often the case) the effluent contains organic materials and complexing agents, the formation of e. g. the 60-Co-EDTA complex prohibits its fixation to the ion exchangers. Accordingly the complexing agent needs to be removed or destroyed. The Institute for Chemistry of the Russian Academy of Sciences has applied the method of hydrothermal treatment (at elevated temperature and pressure, 200 °C, 200 bar), supported by Hydrogen Peroxide oxidation, to allow virtually complete removal of radioactive nuclides on inorganic ion exchangers. Pilot plants have been operated successfully in Russian power stations, and an operational plant has been designed. The method is being extended for an interesting and promising application: spent organic ion exchange resins, loaded up to the medium activity level, represent a serious disposal problem. With the hydrothermal process, in a process cycle, the activity can be stripped from the resins, the organic content is destroyed, and the activity is fixed on an inorganic absorber, well suited for final disposal.
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"Molecular composition - inhibition activity relationships for humic substances narrow fractions sets obtained by solid-phase extraction." In Sixth International Conference on Humic Innovative Technologies "Humic Substances and Eco-Adaptive Technologies ”(HIT – 2021). Non-Commercial Partnership "Center for Biogenic Resources "Humus Sapiens" (NP CBR "Humus Sapiens"), 2021. http://dx.doi.org/10.36291/hit.2021.mikhnevich.001.

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Humic substances (HS) have a wide spectrum of biological activity including inhibitory activity against β-lactamases.1 The latter are capable of hydrolyzing beta-lactam antibiotics and represent one of the main pathways of bacterial antibiotic resistance. HS are characterized by low toxicity and good solubility in water. A use of HS for therapeutic purposes is hindered by extreme molecular heterogeneity and high level of isomeric complexity. Solid-phase extraction (SPE) fractionation in combination with ultra-high resolution mass spectrometry (FTICR MS) is a promising method to simplify this molecular system and isolate the most active components of HS. The aim of this work was to test various SPE fractionation schemes as an approach to directed isolation of the components with the given activity from HS. The sample of coal humic acids (CHA-G) was isolated from the commercial sodium humate “Genesis” and separated using SPE cartridge according to gradients in polarity1 and acidity2 inherent within the molecular components of HS. Inhibitory activity against β- lactamase TEM-1 and its mutants was measured using chromogenic substrate CENTA. Molecular composition of fractions was determined using FTICR mass spectrometer 15 T solariX (Bruker Daltonics) located at the Collective Use Center of Zelinsky Institute of Organic Chemistry of RAS. Molecular assignments were plotted into van Krevelen diagrams. The diagrams were binned into 20 cells are assigned to seven chemotypes, and occupational densities for each chemotype were calculated after Perminova.3 For the fractions separated by polarity, a substantial difference in the molecular composition was observed. Inhibitory activity grew along with an increase in hydrophobicity. The HS activity increased along with an increase in contribution of condensed tannins and phenylisopropanoids (O/C <0.5, H/C <1.4) and decreased along with contribution of hydrolyzed tannins (O/C> 0.5, H/C <1.4). The similar analysis was conducted for the fractions separated with regard to pKa value of the dominating functional groups. The most isomeric complex molecular components were defined, which can be found in different HS fractions, but they are identical in elemental composition. The data obtained make it possible to choose the most efficient fractionation method that effectively lowers the molecular complexity of HS and makes it possible to isolate the most active HS fractions. SPE-fractionation in combination with 2D chromatography is going to be used in our future studies to achieve high resolution separation and more reliable “molecular composition-activity” relationships. Further research might bring substantial advance in the field of directed design of biologically active humic-based materials and compositions. Acknowledgements. This work was supported by the grant of the Russian Science Foundation no 21-73-20202. The center of collective use of the Zelinsky IOC RAS is appreciated. The research was conducted in the framework of the Scientific-Educational School of the Lomonosov MSU “Future of the plant and global environmental change”. References 1. Mikhnevich et al., ACS Omega, 2021, https://doi.org/10.1021/acsomega.1c02841 2. Zherebker et al., Environ. Sci. Technol. 2020, 54, 2667−2677 3. Perminova, I. V. PAC, 2019, 91(5), 851
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