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1

Troller, Simone. Lost in transit: Insufficient protection for unaccompanied migrant children at Roissy Charles de Gaulle Airport. New York, NY: Human Rights Watch, 2009.

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2

Clayton, Matthew. Is Ethical Independence Enough? Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198794394.003.0010.

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Ronald Dworkin’s argument for a general right of ethical independence, in contrast to a special right of religious freedom, represents an important liberal view of the significance of religion within political morality. This chapter seeks to understand and defend Dworkin’s ideal of ethical independence, particularly against those who claim that it provides individuals with insufficient protection to pursue their religious commitments. It does so by integrating ethical independence with other features of Dworkin’s conception of political morality, such as his critique of majoritarianism and his account of equality. In addition, it develops a response to the most prominent version of the insufficiency objection, namely, that the political community ought to give special protection to individuals who seek to honour the dictates of their conscience, or their perceived ethical duties.
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3

Office, General Accounting. Water pollution: State revolving funds insufficient to meet wastewater treatment needs : report to the chairman, Committee on Public Works and Transportation, House of Representatives. Washington, D.C: GAO, 1992.

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4

Moreno-Lax, Violeta. Conclusions. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198701002.003.0011.

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This chapter summarizes the overall conclusions to which the findings arrived at in previous chapters lead. The research points to a persistent disregard of the particular position of exiles in relation to pre-border controls. It emphasizes how the general references to human rights and refugee law introduced in each of the instruments analyzed in Part I are insufficient to guarantee the rights identified in Part II. While ‘integrated border management’ (IBM) measures include some recognition of their potential impact on access to asylum in the Member States, no provision is made for adequate procedures and remedies through which compliance with the protection obligations imposed by EU law would be ensured in practice. On this basis, the chapter closes with a final assessment of IBM tools as currently operationalised, suggesting that either these be adapted to the fundamental rights acquis or abandoned as incompatible with the founding values of the EU.
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5

Hillsdon, Melvyn, and Tim Anstiss. Physical activity and its role in disease prevention. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0337.

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Regular physical activity is one of the most powerful protective and therapeutic factors known to medicine—protecting people from a wide range of health problems and benefitting over 20 conditions and diseases, including coronary heart disease, stroke, diabetes, and cancer. It is also associated with mental well-being and a healthy body weight. Insufficient physical activity, therefore, is a powerful risk factor for a wide range of diseases and health conditions. It is widely prevalent and contributes significantly to burdens of disease and cost. It is detectable and reducible in individuals and groups.
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6

Williams, Jacqueline, and Paul Martin, eds. Defending the Social Licence of Farming. CSIRO Publishing, 2011. http://dx.doi.org/10.1071/9780643104549.

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Issues including climate variability, water scarcity, animal welfare and declining biodiversity have led to increasing demands on farmers to conduct and communicate their farming practices so as to protect their ‘social licence to farm’. Farmers are increasingly expected to demonstrate their social and environmental responsibility as a pre-condition to being allowed to carry out their preferred farming and commercial practices. Current examples include the live animal export trade, battles over protection of aquifers from mining, and contests over rural carbon emissions. In Defending the Social Licence of Farming, authors from Australia, the USA, Europe and Iceland document the diverse issues associated with the 'social licence to farm'. They provide examples of different sectors’ strategies and experiences, and give specific indications of what is involved in coping successfully with this political and legal dimension of farming. As resources become scarce and society’s expectations more diverse and demanding, farming can expect that social licence issues will become both more difficult and more important. The book suggests that the old models of response, largely focused on defensive positions, will often be insufficient to protect the interests of both farmers and the community. This book will provide a useful stimulus for innovation and proactive policies to defend the social licence of the farm sector.
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7

Oliveira, Edinamar Rezende de, and Sônia M. Gomes Sousa. Atendimento Psicossocial às Crianças Vítimas de Abuso sexual. Brazil Publishing, 2021. http://dx.doi.org/10.31012/978-65-5861-412-8.

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This work is the result of a Stricto Sensu Graduate Program research study in psychology at the Pontifical Catholic University of Goiás (PUC Goiás). It aimed to capture the methodologies used and the meanings experienced by psychology professionals while performing psychosocial work on child victims of sexual abuse. In this scenario, the referred research was developed seeking to provoke reflections, expressions and co-production of meanings in relation to this theme. This study is based on the vigotskian socio-historical conception and bibliographical, documentary and empirical research was used as methodological support for data collection. The study concluded that, in several aspects of the psychosocial care offered by Creas, there are numerous challenges for the professionals involved, such as: lack of training for the expected performance, lack of physical structure for most units, lack of diverse resources, lack of specialized materials and lack of collaboration between the different parties within the child care and protection network of the city. Failure in family adherence is an obstacle in treatments according to psychologists. In addition, there are insufficient materials, space and human resources to provide quality care. Finally, the collaboration in the network is pointed as a crucial key for efficiency in treatment.
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8

Beauchamp, Tom L., and David DeGrazia. Principles of Animal Research Ethics. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780190939120.001.0001.

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This book is the first to present a framework of general principles for animal research ethics together with an analysis of the principles’ meaning and moral requirements. This new framework of six moral principles constitutes a more suitable set of moral guidelines than any currently available, including the influential framework presented in the Principles of Humane Experimental Technique published in 1959 by zoologist and psychologist William M. S. Russell and microbiologist Rex L. Burch. Their “principles”—commonly referred to as the Three Rs—are better described as specific directives than as general moral principles, and they are insufficient as a moral framework of basic values in the context of contemporary biomedical and behavioral research. The framework presented in Principles of Animal Research Ethics is more comprehensive in addressing ethical requirements pertaining to societal benefit (the most important consideration in justifying the harming of animals in research) and features a more thorough, ethically defensible program of animal welfare (the area on which Russell and Burch focus). The present framework is also more likely than the Three Rs to foster extensive agreement between the biomedical and animal protection communities—an agreement deeply needed at the present time. The book features commentaries on the framework of principles written by eminent figures in animal research ethics representing an array of relevant disciplines: veterinary medicine, biomedical research, biology, zoology, comparative psychology, primatology, law, and bioethics. The seven commentators on the authors’ Principles are Larry Carbone, Frans B. M. de Waal, Rebecca Dresser, Joseph P. Garner, Brian Hare, Margaret S. Landi, and Julian Savulescu.
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9

van der Vossen, Bas, and Jason Brennan. Economic Objections to Open Borders. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190462956.003.0003.

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The chapter discusses an important set of economic objections to the case for open borders. These objections focus on protecting the wages of domestic workers, maintaining a welfare state, and the effects of admitting migrants who come from illiberal societies. All these objections are shown to be insufficient to overcome the basic case for free movement. They either rely on false empirical claims, or assume—rather than establish—that countries can close their borders to immigrants. As a result, the presumption in favor of free movement, established in the previous chapter, remains undefeated. This concludes the case for open borders.
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10

Henry, M. Stress fractures. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199550647.003.012017.

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♦ Stress fractures are fractures occurring as the result of repetitive, submaximal loads, in the absence of a specific precipitating traumatic event.♦ These fractures can be subdivided into two groups on the basis of aetiology. Whereas ‘fatigue fractures’ result from the excessive repetitive (i.e. abnormal) loading of normal bone, ‘insufficiency fractures’ are fractures resulting from normal forces acting on abnormal bone.♦ Early diagnosis allows the initiation of effective treatment that can prevent prolonged pain and disability, as well as avoiding the progression to displacement or a non-union.♦ While management decisions are generally focused on activity modification, protection of weight bearing, and immobilization, there is a subset of fractures at high risk for progression to complete fracture, non-union, or delayed union. These high-risk stress fractures, including tension-side femoral neck fractures and anterior tibial cortex fractures, require aggressive treatment to prevent the sequelae of poor healing.
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11

Frise, Matthew C., and Jonathan B. Salmon. Disorders of potassium in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0251.

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Plasma potassium levels are maintained in health between 3.5 and 5.0 mmol/L, and reflect total body potassium only in stable states at normal pH. Most true hyperkalaemia results from renal insufficiency. The goals of therapy are myocardial protection and return of plasma potassium to a safe level. Measures are commonly initiated above 5.5 mmol/L; above 6.5 mmol/L, aggressive measures should be adopted and calcium salts given if there are cardiac dysrhythmias or QRS-broadening. Glucose-insulin infusions and beta-2-agonists promote potassium shifts into cells. Diuretics and sodium bicarbonate may be helpful, but persistent hyperkalaemia is an indication for renal replacement therapy. Hypokalaemia may lead to dangerous arrhythmias, skeletal muscle weakness, ileus, and reduced vascular smooth muscle contractility. Rapid replacement should only be undertaken for severe hypokalaemia or in the context of arrhythmias. Once the extracellular deficit is corrected, there will usually be a continuing need for potassium supplementation to replenish intracellular stores.
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12

Esen, Figen. Disorders of magnesium in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0252.

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Plasma potassium levels are maintained in health between 3.5 and 5.0 mmol/L, and reflect total body potassium only in stable states at normal pH. Most true hyperkalaemia results from renal insufficiency. The goals of therapy are myocardial protection and return of plasma potassium to a safe level. Measures are commonly initiated above 5.5 mmol/L; above 6.5 mmol/L, aggressive measures should be adopted and calcium salts given if there are cardiac dysrhythmias or QRS-broadening. Glucose-insulin infusions and beta-2-agonists promote potassium shifts into cells. Diuretics and sodium bicarbonate may be helpful, but persistent hyperkalaemia is an indication for renal replacement therapy. Hypokalaemia may lead to dangerous arrhythmias, skeletal muscle weakness, ileus, and reduced vascular smooth muscle contractility. Rapid replacement should only be undertaken for severe hypokalaemia or in the context of arrhythmias. Once the extracellular deficit is corrected, there will usually be a continuing need for potassium supplementation to replenish intracellular stores.
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13

Follesdal, Andreas. Appreciating the Margin of Appreciation. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198713258.003.0017.

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The European Court of Human Rights (ECtHR) has a practice of granting states a ‘Margin of Appreciation:’ the Court grants states the authority to decide, in some cases, whether they are in compliance with their obligations under the European Convention on Human Rights. This deference by the ECtHR toward states merits philosophical attention: it is criticized by some for being too respectful of state sovereignty and insufficiently protective of human rights, and by others for the reverse. In addition, the ECtHR seems to be employing this practice more frequently. What precisely is this practice, why did it arise, and is it—or can it be made—normatively legitimate? The chapter seeks to specify some vague aspects of the practice, in light of a justification for the legal practice which acknowledges the value of democratic deliberation.
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14

Grzywacz, Joseph G., Abdallah M. Badahdah, and d. Azza O. Abdelmoneium. Work Family Balance: Challenges, Experiences, and Implications for Families. 2nd ed. Hamad Bin Khalifa University Press, 2019. http://dx.doi.org/10.5339/difi_9789927137952.

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A key objective of the study of work-family balance detailed in this report was to build an evidence base to inform policy creation or refinement targeting work-family balance and related implementation standards to ensure the protection and preservation of Qatari families. Two complementary projects were designed and implemented to achieve this key objective. The first project was a qualitative study involving in-depth interviews with 20 Qatari working adults (10 males and 10 females). The interviews were designed to learn the meaning of work-family balance among Qataris, identify the factors shaping work-family balance or the lack thereof, and collect firsthand detailed information on the use and value of policy-relevant work-family balance sup - ports for working Qataris. The second component was a survey designed to describe work-family balance among working Qatari adults, determine potential health and well-being consequences of poor work-family balance, and characterize Qataris’ use of and preferences for new work-family balance supports. The data from the qualitative interviews tell a very clear story of work-family balance among Qataris. Work-family balance is primarily viewed as working adults’ ability to meet responsibilities in both the work and family domains. Although work-fam - ily balance was valued and sought after, participants viewed work-family balance as an idyllic goal that is unattainable. Indeed, when individuals were asked about the last time they experienced balance, the most common response was “during my last vacation or extended holiday.” The challenge of achieving work-family balance was equally shared by males and females, although the challenge was heightened for females. Qataris recognized that “work” was essential to securing or providing a desirable family life; that is, work provided the financial wherewithal to obtain the features and comforts of contemporary family life in Qatar. However, the cost of this financial wherewithal was work hours and a psychological toll characterized as “long” and “exhausting” which left workers with insufficient time and energy for the family. Participants commented on the absolute necessity of paid maternity leave for work-family balance, and suggested it be expanded. Participants also discussed the importance of high-quality childcare, and the need for greater flexibility for attending to family responsibilities during the working day. Data from the quantitative national survey reinforce the results from the qualitative interviews. Work-family balance is a challenge for most working adults: if work-fam - ily balance were given scores like academic grades in school, the majority of both males and females would earn a "C" or lower (average, minimal pass or failure). As intimated in the qualitative data, working females’ work-family balance is statistically poorer than that of males. Poor work-family balance is associated with poorer physical and mental health, with particularly strong negative associations with depression. It appears the Human Resource Law of 2016 was effective in raising awareness of and access to paid maternity leave. However, a substantial minority of working Qataris lack access to work-family balance supports from their employer, and the supports that are provided by employers do not meet the expectations of the average Qatari worker.
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15

Wójcik-Gładysz, Anna. Ghrelin – hormone with many faces. Central regulation and therapy. The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 2020. http://dx.doi.org/10.22358/mono_awg_2020.

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Discovered in 1999, ghrelin, is one of the peptides co-creating the hypothalamicgastrointestinal axis, otherwise known as the brain-gut axis. Ghrelin participates in many physiological processes and spectrum of its activity is still being discovered. This 28 amino acid peptide ‒ a product of the ghrl gene, was found in all vertebrates and is synthesized and secreted mainly from enteroendocrine X/A cells located in the gastric mucosa of the stomach. Expression of the ghrelin receptor has been found in many nuclei of the hypothalamus involved in appetite regulation. Therefore it’s presumed that ghrelin is one of the crucial hormones deciphering the energy status required for the maintenance of organism homeostasis. Ghrelin acts as a signal of starvation or energy insufficiency and its level in plasma is reduced after the meal. Neuropeptide Y (NPY) and agouti-related peptide (AgRP; NPY/AgRP) neurons located in the arcuate nucleus (ARC) area are the main target of ghrelin in the hypothalamus. This subpopulation of neurons is indispensable for inducing orexigenic action of ghrelin. Moreover ghrelin acting as a neurohormone, mainly in the hypothalamus area, plays an important role in the regulation of growth and reproduction processes. Indeed, ghrelin action on reproductive processes has been observed in the systemic effects exerted at both hypothalamus-pituitary and gonadal levels. Similarly the GH-releasing ghrelin action was observed both on the hypothalamus level and directly on the somatotrophic cells in the pituitary and this dose-related GH releasing activity was found in in vitro as well as in in vivo experiments. In recent years, numerous studies revealed that ghrelin potentially takes part in the treatment of diseases associated with serious disturbances in the organism energy balance and/or functioning of the gastrointestinal tract. It was underlined that ghrelin may be a hormone with a broad spectrum of therapeutic effect on obesity and anorexia nervosa, as well as may also have protective effect on neurodegenerative diseases, inflammatory disorders or functional changes in the body caused by cancers. In overall, ghrelin treatment has been tested in over 100 preclinical studies with healthy volunteers as well as patients with various types of cancer, eating disorders such as anorexia nervosa and bulimia nervosa. It was observed that ghrelin has an excellent clinical safety profile and emerging side effects occurred only in 3–10% of patients and did not constitute a sufficient premise to discontinue the therapy. In general, it can be concluded that ghrelin may be sufficiently used as a prescription drug.
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