Academic literature on the topic 'Insulin action'

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Journal articles on the topic "Insulin action"

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Meyts, Pierre De, Claus T. Christoffersen, Hans Tornqvist, and Klaus Seedorf. "Insulin receptors and insulin action." Current Opinion in Endocrinology and Diabetes 3, no. 5 (1996): 1. http://dx.doi.org/10.1097/00060793-199610000-00003.

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Kucera, Michelle L., and John P. Graham. "Insulin Lispro, a New Insulin Analog." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 18, no. 3 (1998): 526–38. http://dx.doi.org/10.1002/j.1875-9114.1998.tb03116.x.

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Insulin lispro is a rapid‐acting insulin analog to regular insulin. Inversion of the proline‐lysine amino acid sequence at positions 28 and 29 on the B chain is responsible for its more rapid absorption, faster onset, and shorter duration of action compared with regular insulin. The fast onset of action allows for greater flexibility in dosing and mealtime scheduling. Insulin lispro provides equivalent or slightly improved glycemic control in patients with types I and II diabetes mellitus compared with regular insulin, without subsequent increases in hypoglycemic episodes. It also results in g
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Bailey, CJ. "Improved Insulin Action." Emerging Therapeutic Targets 1, no. 1 (1997): 229–33. http://dx.doi.org/10.1517/14728222.1.1.229.

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Taylor, Roy. "Insulin action 1991." Clinical Endocrinology 34, no. 2 (1991): 159–71. http://dx.doi.org/10.1111/j.1365-2265.1991.tb00287.x.

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Hausmann, Simone, and Siegfried Ussar. "Insulin receptor trafficking steers insulin action." Molecular Metabolism 5, no. 4 (2016): 253–54. http://dx.doi.org/10.1016/j.molmet.2016.02.004.

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Dedov, I. I., and M. V. Shestakova. "On the centenary of the insulin discovery." Diabetes mellitus 24, no. 1 (2021): 11–16. http://dx.doi.org/10.14341/dm12733.

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The discovery of insulin and the beginning of its use in 1921–1922 made a revolution in endocrinology and in medicine in general. This significant event gave millions of patients with diabetes not only the opportunity to live, but also the hope that their life with this disease would be full.The article examines the history of insulin discovery, as well as the evolution of several generations of insulin preparations and the advantages of each of the generations that have radically changed not only life expectancy, but also its quality.The first generation — insulins of animal origin and the so
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Liu, Jia, and Zhenqi Liu. "Muscle Insulin Resistance and the Inflamed Microvasculature: Fire from Within." International Journal of Molecular Sciences 20, no. 3 (2019): 562. http://dx.doi.org/10.3390/ijms20030562.

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Insulin is a vascular hormone and regulates vascular tone and reactivity. Muscle is a major insulin target that is responsible for the majority of insulin-stimulated glucose use. Evidence confirms that muscle microvasculature is an important insulin action site and critically regulates insulin delivery to muscle and action on myocytes, thereby affecting insulin-mediated glucose disposal. Insulin via activation of its signaling cascade in the endothelial cells increases muscle microvascular perfusion, which leads to an expansion of the endothelial exchange surface area. Insulin’s microvascular
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Hirsch, Irl B., Rattan Juneja, John M. Beals, Caryl J. Antalis, and Eugene E. Wright. "The Evolution of Insulin and How it Informs Therapy and Treatment Choices." Endocrine Reviews 41, no. 5 (2020): 733–55. http://dx.doi.org/10.1210/endrev/bnaa015.

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Abstract Insulin has been available for the treatment of diabetes for almost a century, and the variety of insulin choices today represents many years of discovery and innovation. Insulin has gone from poorly defined extracts of animal pancreata to pure and precisely controlled formulations that can be prescribed and administered with high accuracy and predictability of action. Modifications of the insulin formulation and of the insulin molecule itself have made it possible to approximate the natural endogenous insulin response. Insulin and insulin formulations had to be designed to produce ei
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Ming, Zhi, and W. Wayne Lautt. "HISS, not insulin, causes vasodilation in response to administered insulin." Journal of Applied Physiology 110, no. 1 (2011): 60–68. http://dx.doi.org/10.1152/japplphysiol.00714.2010.

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Meal-induced sensitization to the dynamic actions of insulin results from the peripheral actions of a hormone released by the liver (hepatic insulin sensitizing substance or HISS). Absence of meal-induced insulin sensitization results in the pathologies associated with cardiometabolic risk. Using three protocols that have previously demonstrated HISS metabolic action, we tested the hypothesis that HISS accounts for the vasodilation that has been associated with insulin. The dynamic metabolic actions of insulin and HISS were determined using a euglycemic clamp in response to a bolus of 100 mU/k
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Cheatham, B. "Insulin action and the insulin signaling network." Endocrine Reviews 16, no. 2 (1995): 117–42. http://dx.doi.org/10.1210/er.16.2.117.

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Dissertations / Theses on the topic "Insulin action"

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Baynes, Christospher. "Insulin action and dyslipidaemia in non-insulin-dependent diabetes." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316405.

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Tavare, J. M. "The insulin receptor and insulin stimulated protein kinase : Their role in insulin action." Thesis, University of Bristol, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370675.

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Chowdhury, S. A. "Studies of insulin action in muscle." Thesis, University of Newcastle Upon Tyne, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377653.

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Taylor, Roy. "Cellular insulin action in metabolic disease." Thesis, University of Edinburgh, 1985. http://hdl.handle.net/1842/20241.

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Ng, Foong Loo Yvonne Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Insulin action: unravelling AKT signalling in Adipocytes." Awarded by:University of New South Wales. Biotechnology & Biomolecular Sciences, 2009. http://handle.unsw.edu.au/1959.4/44628.

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The Ser/Thr kinase Akt plays an important role in many of insulin's actions including GLUT4 translocation to the plasma membrane (PM). However, there are several features of Akt's regulation of GLUT4 translocation that remain unclear. The goal of my thesis was to resolve some of the following questions: Is activation of Akt sufficient to stimulate GLUT4 translocation? What is the quantitative relationship in signal transmission between individual components within the Akt cascade? What is the role of Akt in insulin resistance? To determine if activation of Akt is sufficient to mediate GLUT4 tr
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Whitelaw, Donald C. "Aspects of insulin secretion and action in non-insulin-dependent diabetes mellitus." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/22738.

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In a cross-sectional survey of coronary risk factors in subjects with recently diagnosed NIDDM I confirm the high prevalence of individual risk factors described by others, and show a broadly normal distribution pattern for the clustering of risk factors forming Reaven's Syndrome X, in contrast to that reported in other populations. I suggest that hyperinsulinaemia and hypertriglyceridaemia are the best markers of high coronary risk and note the association of obesity and other risk factors. In a study to examine the effects of the new oral hypoglycaemic drug A4166 in NIDDM I confirm its major
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Westerbacka, Jukka. "Insulin action on large artery stiffness in normal and insulin resistant subjects." Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/westerbacka/.

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Melvin, Alison Jane. "Phospholipid fatty acid composition and insulin action." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413198.

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Thorn, Hans. "Caveolae structure and importance in insulin action /." Linköping : Univ, 2004. http://www.bibl.liu.se/liupubl/disp/disp2004/med875s.pdf.

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Argyraki, M. "Studies of insulin action in human muscle." Thesis, University of Newcastle Upon Tyne, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234398.

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Books on the topic "Insulin action"

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Srivastava, Ashok K., and Barry I. Posner, eds. Insulin Action. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5647-3.

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K, Srivastava Ashok, and Posner Barry I. 1937-, eds. Insulin action. Kluwer Academic Publishers, 1998.

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Espinal, J. Understanding Insulin Action. Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-1475-2.

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Saltiel, Alan R., and Jeffrey E. Pessin. Mechanisms of Insulin Action. Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-72204-7.

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Joseph, Goren H., Hollenberg Morley D. 1942-, and Roncari Daniel A. K, eds. Insulin action and diabetes. Raven Press, 1988.

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Sudhesh, Kumar, and O'Rahilly S, eds. Insulin resistance: Insulin action and its disturbances in disease. J. Wiley, 2005.

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Czech, Michael P., ed. Molecular Basis of Insulin Action. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-4874-0.

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P, Czech Michael, ed. Molecular basis of insulin action. Plenum Press, 1985.

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Iwar, Klimes, ed. Dietary lipids and insulin action. New York Academy of Sciences, 1993.

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Kleinridders, André. Physiological Consequences of Brain Insulin Action. CRC Press, 2022. http://dx.doi.org/10.1201/9781003079927.

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Book chapters on the topic "Insulin action"

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White, Morris F. "The IRS-signalling system: A network of docking proteins that mediate insulin action." In Insulin Action. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5647-3_1.

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Goldstein, Barry J., Faiyaz Ahmad, Wendi Ding, Pei-Ming Li, and Wei-Ren Zhang. "Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases." In Insulin Action. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5647-3_10.

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Byon, John C. H., Anasua B. Kusari, and Jyotirmoy Kusari. "Protein-tyrosine Phosphatase-1B acts as a negative regulator of insulin signal transduction." In Insulin Action. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5647-3_11.

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Fantus, I. George, and Evangelia Tsiani. "Multifunctional actions of vanadium compounds on insulin signaling pathways: Evidence for preferential enhancement of metabolic versus mitogenic effects." In Insulin Action. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5647-3_12.

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Sweeney, Gary, and Amira Klip. "Regulation of the Na+/K+- ATPase by insulin: Why and how?" In Insulin Action. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5647-3_13.

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Srivastava, Ashok K., and Sanjay K. Pandey. "Potential mechanism (S) involved in the regulation of glycogen synthesis by insulin." In Insulin Action. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5647-3_14.

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Charron, Maureen J., and Ellen B. Katz. "Metabolic and therapeutic lessons from genetic manipulation of GLUT4." In Insulin Action. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5647-3_15.

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Zierath, Juleen R., Anna Krook, and Harriet Wallberg-Henriksson. "Insulin action in skeletal muscle from patients with NIDDM." In Insulin Action. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5647-3_16.

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Lamothe, Betty, Bertrand Duvillié, Nathalie Cordonnier, et al. "Genetic manipulation of insulin action and β-cell function in mice." In Insulin Action. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5647-3_17.

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Peraldi, Pascal, and Bruce Spiegelman. "TNF-α and insulin resistance: Summary and future prospects." In Insulin Action. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5647-3_18.

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Conference papers on the topic "Insulin action"

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Lin, J., P. Docherty, A. Le Compte, et al. "Modeled Insulin Sensitivity and Interstitial Insulin Action from a Pilot Study of Dynamic Insulin Sensitivity Tests." In UKACC International Conference on CONTROL 2010. Institution of Engineering and Technology, 2010. http://dx.doi.org/10.1049/ic.2010.0358.

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Stahl, Fredrik, Rolf Johansson, and Mona Landin Olsson. "Predicting Nocturnal Hypoglycemia Using a Non-parametric Insulin Action Model." In 2015 IEEE International Conference on Systems, Man, and Cybernetics (SMC). IEEE, 2015. http://dx.doi.org/10.1109/smc.2015.280.

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Bogdanova, N. V., V. V. Sagan, and O. A. Sokolovich. "INFLUENCE OF PHYSICO-CHEMICAL FACTORS ON THE PROCESS OF FIBRILLATION OF THE INSULIN MOLECULE." In SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2021. http://dx.doi.org/10.46646/sakh-2021-2-24-27.

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As a result of the research, data on the dynamics of fibrillation of insulin molecules under different temperature conditions are presented. The influence of the pH of the medium and mechanical action on the processes of amyloid formation is also studied. In vitro experiments revealed three stages of fibrillation of insulin molecules.
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Kullmann, S., L. Wagner, R. Veit, et al. "Exercise improves brain insulin action in sedentary overweight and obese adults." In Diabetes Kongress 2019 – 54. Jahrestagung der DDG. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1688160.

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Martin, Jason, Ralf Veit, Andreas L. Birkenfeld, Martin Heni, Hubert Preissl, and Stephanie Kullmann. "Brain insulin action increases communication in reward associated brain regions independent of age and peripheral insulin sensitivity in healthy adults." In Diabetes Kongress 2023 - 57. Jahrestagung der DDG. Georg Thieme Verlag, 2023. http://dx.doi.org/10.1055/s-0043-1767831.

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Rashid, Mudassir, Iman Hajizadeh, and Ali Cinar. "Predictive Control with Variable Delays in Plasma Insulin Action for Artificial Pancreas." In 2018 IEEE Conference on Decision and Control (CDC). IEEE, 2018. http://dx.doi.org/10.1109/cdc.2018.8619230.

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Moretti, Matteo, Robert Hauffe, Lydia Häußler, Julia Sophie Meßner, and André Kleinridders. "Investigating the impact of GPx3 on selenite induced insulin action in adipocytes." In Diabetes. Umwelt. Leben. Perspektiven aus allen Blickwinkeln. Georg Thieme Verlag KG, 2024. http://dx.doi.org/10.1055/s-0044-1785341.

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Urzeala, Constanta, and Mihaela Vlaiculescu. "TELEMEDICINE AND PHYSICAL EXERCISE FOR THE CHILD WITH DIABETES." In eLSE 2016. Carol I National Defence University Publishing House, 2016. http://dx.doi.org/10.12753/2066-026x-16-241.

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This paper is a case study that highlights our concern for increasing the quality of life of the child with diabetes, using telemedicine devices. The central objective is to emphasize the efficiency of the Omnipod wireless insulin pump in the case of a child who, together with the diabetes care team, appropriately manages this metabolic disease and whose treatment also includes physical exercise. Our interest is oriented towards proving the effects derived from the practice of physical exercises on decreasing the amount of insulin administered during the days when the child participates in mot
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HASSAN, Neeran F. "USING INCRETIN IN TREATMENT OF DIABETES MELLITUS DISEASE." In IV.International Scientific Congress of Pure,Appliedand Technological Sciences. Rimar Academy, 2022. http://dx.doi.org/10.47832/minarcongress4-29.

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Incretin hormones are gut peptides secreted in response to nutrient ingestion, which play a key role in the regulation of islet function and blood glucose levels. In humans, the major incretin hormones are glucagon-like peptide (GLP)-1 and glucose- dependent insulinotropic polypeptide (GIP), and together they fully account for the incretin effect which is defined as the phenomenon whereby orally ingested glucose elicits a much greater insulin response than that obtained when glucose is infused intravenously to give identical blood glucose levels. there is evidence to suggest that impairments i
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Diniz, Clebiana Alves e. silva, Poliana Silva de Brito, Tainan de Andrade Rocha, Suzana Maria de Oliveira Costa Meneses, and Julia Maria Pacheco Lins Magalhães. "Elderly people with diabetes: an analysis of the factors that are associated with lower limb amputation." In II INTERNATIONAL SEVEN MULTIDISCIPLINARY CONGRESS. Seven Congress, 2023. http://dx.doi.org/10.56238/homeinternationalanais-028.

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Abstract Population aging has been occurring extremely rapidlyin developing countries, implying a higher prevalence of chronic-degenerative diseases (NCDs,s). Among these, diabetes mellitus stands out, a syndrome characterized by a chronic state of hyperglycemia and disorders in the metabolism of carbohydrates, lipids and proteins, associated with absolute or relative insulin deficiency and/or its action in the body.
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Reports on the topic "Insulin action"

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Boisclair, Yves R., and Arieh Gertler. Development and Use of Leptin Receptor Antagonists to Increase Appetite and Adaptive Metabolism in Ruminants. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7697120.bard.

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Objectives The original project had 2 major objectives: (1) To determine the effects of centrally administered leptin antagonist on appetite and adaptive metabolism in the sheep; (2) To develop and prepare second-generation leptin antagonists combining high binding affinity and prolonged in vivo half-life. Background Periods of suboptimal nutrition or exaggerated metabolic activity demands lead to a state of chronic energy insufficiency. Ruminants remain productive for a surprisingly long period of time under these circumstances by evoking adaptations sparing available energy and nutrients. Th
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Barash, Itamar, and Robert Rhoads. Translational Mechanisms Governing Milk Protein Levels and Composition. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7696526.bard.

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Original objectives: The long-term goal of the research is to achieve higher protein content in the milk of ruminants by modulating the translational apparatus of the mammary gland genetically, nutritionally, or pharmacologically. The short-term objectives are to obtain a better understanding of 1) the role of amino acids (AA) as regulators of translation in bovine and mouse mammary epithelial cells and 2) the mechanism responsible for the synergistic enhancement of milk-protein mRNA polyadenylation by insulin and prolactin. Background of the topic: In many cell types and tissues, individual A
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Meidan, Rina, and Robert Milvae. Regulation of Bovine Corpus Luteum Function. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7604935.bard.

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The main goal of this research plan was to elucidate regulatory mechanisms controlling the development, function of the bovine corpus luteum (CL). The CL contains two different sterodigenic cell types and therefore it was necessary to obtain pure cell population. A system was developed in which granulosa and theca interna cells, isolated from a preovulatory follicle, acquired characteristics typical of large (LL) and small (SL) luteal cells, respectively, as judged by several biochemical and morphological criteria. Experiments were conducted to determine the effects of granulosa cells removal
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Sooksai, Sarintip, Nanthika Khongchareonporn, Aphichart Karnchanatat, Shongchan Phuthong, Sajee Noitang, and Sawanan Thongyoo. Enhancement of recombinant monomeric insulin production in methylotrophic yeasts by increasing copy number of gene : Completed research report (2nd year). Chulalongkorn University, 2016. https://doi.org/10.58837/chula.res.2016.59.

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Insulin is a hormone that is produced in pancreas. It is important for regulation of blood sugar level. The active form of insulin is monomer which contains 51 amino acids in two peptide chains. Currently, improvement of insulin production was done by using recombinant DNA technology in bacteria and yeasts. The obtained recombinant insulin is easier to be purified than the pancreatic insulin. This research has been using the recombinant yeast, Pichia pastoris KM71H (TP1), which has a cassette of monomeric insulin precursor (MIP) to produce recombinant MIP. The recombinant MIP was induced to be
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Yibchok-anun, Sirinthorn, Wijit Banlunara, and Sirichai Adisakwattana. Antidiabetic effects, mechanisms of of p-methoxy-trans-cinnamic acid. Faculty of Veterinary Science, Chulalongkorn University, 2008. https://doi.org/10.58837/chula.res.2008.81.

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p-Methoxycinnamic acid (p-MCA) is a cinnamic acid derivative that shows various pharmacologic actions such as neuroprotective and hepatoprotective activities. To examine the insulinotropic activity of p-MCA, the perfused rat pancreas and a pancreatic β-cell line, INS-1 were used in the studies. P-MCA increased insulin secretion from the perfused rat pancreas and INS-1 cells in a concentration-dependent manner. In addition, p-MCA increased intracellular Ca²⁺ concentration ([Ca²⁺]i) in INS-1 cells. The p-MCA-induced insulin secretion and rise in [Ca²⁺]i were markedly inhibited in the absence of
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Hansen, Peter J., and Amir Arav. Embryo transfer as a tool for improving fertility of heat-stressed dairy cattle. United States Department of Agriculture, 2007. http://dx.doi.org/10.32747/2007.7587730.bard.

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The overall objective of the current proposal is to develop procedures to improve the pregnancy rate achieved following transfer of fresh or cryopreserved embryos produced in the laboratory into heat-stress recipients. The overall hypothesis is that pregnancy rate in heat-stressed lactating cows can be improved by use of embryo transfer and that additional gains in pregnancy rate can be achieved through development of procedures to cryopreserve embryos, select embryos most likely to establish and maintain pregnancy after transfer, and to enhance embryo competence for post-transfer survival thr
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Hung, Hsuan-Yu, and Chung-Yu Chen. The impact of Sofosbuvir/Velpatasvir/Voxilaprevir treatment on serum hyperglycemia in HCV infections: A Systematic Review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2021. http://dx.doi.org/10.37766/inplasy2021.12.0109.

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Review question / Objective: To assess the possible cause of events, the incidence of grade 3 hyperglycemia after treating Sofosbuvir/Velpatasvir/Voxilaprevir in HCV infections. Condition being studied: Sofosbuvir, velpatasvir, and voxilaprevir (SOF/VEL/VOX) is an effective, safe rescue therapy regimen for patients have previously been treated failure. Initiating Direct-Acting Antiviral (DAA) treatment for HCV infection with diabetes have experienced hypoglycemia, it could improve insulin resistance due to clean HCV. However, some studies shown that SOF/VEL/VOX has Grade 3 hyperglycemia advers
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Xie, Yunhui, and Peng Pang. A Systematic Review and Network Meta-Analysis: Effect of of GLP-1 drugs on weight loss in obese people. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.6.0074.

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Review question / Objective: 1、Whether GLP-1 drugs have weight loss effect on obese people ? 2、Which GLP-1 drugs are most effective in weight loss among obese people ? Condition being studied: Obesity is an important public health issue that has been on the rise over the last decades. It calls for effective prevention and treatment. Bariatric surgery is the most effective medical therapy for weight loss in morbid obesity, but we are in need for less aggressive treatments. Glucagon-like-peptide-1 receptor agonists are a group of incretin-based drugs that have proven to be productive for obesity
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Lindquist, Christine, and Tasseli McKay. Sexual Harassment Experiences and Consequences for Women Faculty in Science, Engineering, and Medicine. RTI Press, 2018. http://dx.doi.org/10.3768/rtipress.2018.pb.0018.1806.

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In a qualitative study of 40 women faculty in sciences, engineering, and medicine (http://sites.nationalacademies.org/SexualHarrassment.htm), respondents at all career levels and fields reported a range of sexual harassment experiences, including gender-based harassment (e.g., gendered insults, lewd comments), unwanted sexual advances, stalking, and sexual assault by a colleague. Sexual harassment experiences often diminished study participants' scientific productivity as energy was diverted into efforts to process emotional responses, manage the perpetrator, report the harassment, or work to
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O'Connor, Jack, Caitlyn Eberle, Davide Cotti, et al. Interconnected Disaster Risks. United Nations University - Institute for Environment and Human Security (UNU-EHS), 2021. http://dx.doi.org/10.53324/nyhz4182.

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We live in an interconnected world, where disaster risks are increasing every day. In 2020/2021 alone, the world witnessed a number of record-breaking disasters that showed us clearer than ever before how interconnected we are, for better or worse. These disasters are symbols of underlying global issues that we must identify and address in order to better manage risk. This report analyses 10 disastrous events that occurred in 2020/2021 and explains that these events are interconnected with each other, with other larger, underlying societal processes, and with our behaviors and actions. We show
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