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1

Lee, Chang Hoon, Chin Saeng Cho, Kyung-You Park, Joon Woo Kim, Gwan Won Lee, Byung Kwon Lee, and Jae Soo Lee. "The Role of Insulin-Like Growth Factor I and Binding Protein in Cholesteatoma Fibroblasts." Journal of Clinical Otolaryngology Head and Neck Surgery 14, no. 1 (May 2003): 113–17. http://dx.doi.org/10.35420/jcohns.2003.14.1.113.

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2

Purwana, Arie, Budiono Budiono, Jose RL Batubara, and Muhammad Faizi. "Association of Growth Velocity with Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Children with a Vegan Diet." Journal of Biomedicine and Translational Research 6, no. 1 (February 6, 2020): 6–10. http://dx.doi.org/10.14710/jbtr.v6i1.5474.

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Background: The vegan diet in children provides the benefit of reducing the risk of being overweight and improving the fat profile. The risk that can occur in the provision of a vegan diet in children is anthropometric size below reference and low caloric intake. Growth hormone (GH) and Insulin like Growth Factors (IGFs) are powerful stimulators for longitudinal growth of bone and require insulin-like growth factor binding protein (IGFBPs) which acts as a transport protein for IGF-1. A vegan diet with lower calorie intake in children has lower IGF-I levels than children with an omnivorous diet
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3

Kostecká, Z., and J. Blahovec. "Animal insulin-like growth factor binding proteins and their biological functions." Veterinární Medicína 47, No. 2 - 3 (March 30, 2012): 75–84. http://dx.doi.org/10.17221/5807-vetmed.

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Insulin-like growth factor (IGF-I, IGF-II) action is influenced by until today known eight forms of insulin-like growth factor binding proteins (IGFBPs). They have been obtained not only from some human and animal tissues and body fluids but also from conditioned medium of cell cultures. An important biological property of the IGFBPs is their ability to increase the circulating half-life of the IGFs. They are able to act as potentiators of cell proliferation. As IGFBPs bind to cell surfaces, they may act either to deliver the IGFs to those surfaces for activation of specific receptors or to ac
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4

Haugaard, Steen B., Ove Andersen, Birgitte R. Hansen, Hans Ørskov, Ulrik B. Andersen, Sten Madsbad, Johan Iversen, and Allan Flyvbjerg. "Insulin-like growth factors, insulin-like growth factor-binding proteins, insulin-like growth factor-binding protein-3 protease, and growth hormone-binding protein in lipodystrophic Human Immunodeficiency Virus-infected patients." Metabolism 53, no. 12 (December 2004): 1565–73. http://dx.doi.org/10.1016/j.metabol.2004.06.025.

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5

Rutanen, Eeva-Marja. "Insulin-Like Growth Factor Binding Protein-1." Seminars in Reproductive Medicine 10, no. 02 (May 1992): 154–63. http://dx.doi.org/10.1055/s-2007-1018871.

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6

Clay Bunn, R., and John L. Fowlkes. "Insulin-like growth factor binding protein proteolysis." Trends in Endocrinology & Metabolism 14, no. 4 (May 2003): 176–81. http://dx.doi.org/10.1016/s1043-2760(03)00049-3.

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7

Wang, Hsin-Shih, Jing-Der Lee, Bor-Jen Cheng, and Yung-Kuei Soong. "Insulin-like growth factor-binding protein 1 and insulin-like growth factor-binding protein 3 in pre-eclampsia." BJOG: An International Journal of Obstetrics and Gynaecology 103, no. 7 (July 1996): 654–59. http://dx.doi.org/10.1111/j.1471-0528.1996.tb09833.x.

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8

Kobayashi, S., D. R. Clemmons, and M. A. Venkatachalam. "Colocalization of insulin-like growth factor-binding protein with insulin-like growth factor I." American Journal of Physiology-Renal Physiology 261, no. 1 (July 1, 1991): F22—F28. http://dx.doi.org/10.1152/ajprenal.1991.261.1.f22.

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We report the localization of insulin-like growth factor I (IGF-I) and a 25-kDa form of insulin-like growth factor-binding protein (IGF-BP-1) in adult rat kidney. The antigens were localized using a rabbit anti-human IGF-I antibody, and a rabbit anti-human IGF-BP-1 antibody raised against human 25-kDa IGF-BP-1 purified from amniotic fluid. Immunohistochemistry by the avidin-biotin peroxidase conjugate technique showed that both peptides are located in the same nephron segments, in the same cell types. The most intense staining was in papillary collecting ducts. There was moderate staining also
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9

Ryu, Hye-Young, Hye-Jung Hwang, In-Hye Kim, Hong-Soo Ryu, and Taek-Jeong Nam. "Effects of Glucose on Insulin-like Growth Factor Binding-5 Expression in Human Fibroblasts." Journal of Life Science 17, no. 9 (September 30, 2007): 1224–31. http://dx.doi.org/10.5352/jls.2007.17.9.1224.

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10

Conover, C. A., J. T. Clarkson, and L. K. Bale. "Factors regulating insulin-like growth factor-binding protein-3 binding, processing, and potentiation of insulin-like growth factor action." Endocrinology 137, no. 6 (June 1996): 2286–92. http://dx.doi.org/10.1210/endo.137.6.8641177.

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11

Zumkeller, Walter, and Kerstin Hall. "Immunoreactive insulin-like growth factor II in urine." Acta Endocrinologica 123, no. 5 (November 1990): 499–503. http://dx.doi.org/10.1530/acta.0.1230499.

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Abstract. Insulin-like growth factor II and insulin-like growth factor binding protein-1 were identified and quantified in the urine of 23 healthy subjects between 17 and 76 years of age. IGF-II was measured after separation by gel chromatography at low pH and compared with IGF-I levels in the same samples, whereas IGF binding protein-1 was measured in dialysed urine. Urinary IGF-II was found at much higher concentrations than IGF-I (mean ±sem: 717±69 vs 110±5 ng/mmol creatinine). The chromatographic profile indicates that pro-IGF-II may also be present. The concentrations of IGF-II appear to
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12

Cohen, Pinchas. "Insulin-Like Growth Factor Binding Protein-3: Insulin-Like Growth Factor Independence Comes of Age." Endocrinology 147, no. 5 (May 1, 2006): 2109–11. http://dx.doi.org/10.1210/en.2006-0195.

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13

Hasegawa, Yukihiro. "Relationship between Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-3." Clinical Pediatric Endocrinology 5, Supple8 (1996): 89–93. http://dx.doi.org/10.1297/cpe.5.supple8_89.

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14

Bach, L. "Insulin-Like Growth Factor Binding Protein-6: The “Forgotten” Binding Protein?" Hormone and Metabolic Research 31, no. 02/03 (January 1999): 226–34. http://dx.doi.org/10.1055/s-2007-978723.

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15

Bereket, Abdullah, Yasar Cesur, Behzat Ozkan, Erdal Adal, Serap Turan, Sertac Hanedan Onan, Hakan Döneray Doneray, Teoman Akcay, and Goncagul Haklar. "Circulating Insulin-like Growth Factor Binding Protein-4." Journal of Clinical Research in Pediatric Endocrinology 2, no. 1 (March 12, 2010): 17–20. http://dx.doi.org/10.4274/jcrpe.v2i1.17.

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16

Rosenfeld, Ron G., Vivian Hwa, Elizabeth Wilson, Stephen R. Plymate, and Youngman Oh. "The insulin-like growth factor-binding protein superfamily." Growth Hormone & IGF Research 10 (January 2000): S16—S17. http://dx.doi.org/10.1016/s1096-6374(00)90007-8.

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17

Ricort, Jean-Marc. "Insulin-like growth factor binding protein (IGFBP) signalling." Growth Hormone & IGF Research 14, no. 4 (August 2004): 277–86. http://dx.doi.org/10.1016/j.ghir.2004.02.002.

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18

Gabbitas, Bari, and Ernesto Canalis. "Insulin-like growth factors sustain insulin-like growth factor-binding protein-5 expression in osteoblasts." American Journal of Physiology-Endocrinology and Metabolism 275, no. 2 (August 1, 1998): E222—E228. http://dx.doi.org/10.1152/ajpendo.1998.275.2.e222.

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Insulin-like growth factors (IGFs) I and II are considered to be autocrine regulators of bone cell function. Recently, we demonstrated that IGF-I induces IGF-binding protein-5 (IGFBP-5) expression in cultures of osteoblast-enriched cells from 22-day fetal rat calvariae (Ob cells). In the present study, we postulated that IGFs play an autocrine role in the maintenance of IGFBP-5 basal expression in Ob cells. IGFBP-2 and -3, at concentrations that bind endogenous IGFs, decreased IGFBP-5 mRNA levels, as determined by Northern blot analysis, and protein levels, as determined by Western immunoblots
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19

Janssen, J. A. M. J. L., R. P. Stolk, H. A. P. Pols, D. E. Grobbee, and S. W. J. Lamberts. "Serum Free and Total Insulin-Like Growth Factor-I, Insulin-Like Growth Factor Binding Protein-1 and Insulin-Like Growth Factor Binding Protein-3Levels in Healthy Elderly Individuals." Gerontology 44, no. 5 (1998): 277–80. http://dx.doi.org/10.1159/000022026.

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20

Iglesias, P., C. Bayón, J. Méndez, P. González Gancedo, C. Grande, and J. J. Díez. "Serum Insulin-Like Growth Factor Type 1, Insulin-Like Growth Factor-Binding Protein-1, and Insulin-Like Growth Factor-Binding Protein-3 Concentrations in Patients with Thyroid Dysfunction." Thyroid 11, no. 11 (November 2001): 1043–48. http://dx.doi.org/10.1089/105072501753271734.

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21

Pirazzoli, P., E. Cacciari, R. De Iasio, M. C. Pittalis, P. Dallacasa, S. Zucchini, S. Gualandi, S. Salardi, C. David, and S. Boschi. "Developmental pattern of fetal growth hormone, insulin-like growth factor I, growth hormone binding protein and insulin-like growth factor binding protein-3." Archives of Disease in Childhood - Fetal and Neonatal Edition 77, no. 2 (September 1, 1997): F100—F104. http://dx.doi.org/10.1136/fn.77.2.f100.

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22

Zimmermann, E. M., L. Li, Y. T. Hou, N. K. Mohapatra, and J. B. Pucilowska. "Insulin-like growth factor I and insulin-like growth factor binding protein 5 in Crohn's disease." American Journal of Physiology-Gastrointestinal and Liver Physiology 280, no. 5 (May 1, 2001): G1022—G1029. http://dx.doi.org/10.1152/ajpgi.2001.280.5.g1022.

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Insulin-like growth factor (IGF)-I and its binding protein IGF binding protein 5 (IGFBP-5) were highly expressed in inflamed and fibrotic intestine in experimental Crohn's disease. IGF-I induced proliferation and increased collagen synthesis by smooth muscle cells and fibroblasts/myofibroblasts in vitro. Here we studied IGF-I and IGFBP-5 in Crohn's disease tissue. Tissue was collected from patients undergoing intestinal resection for Crohn's disease. IGF-I and IGFBP-5 mRNAs were quantitated by RNase protection assay and Northern blot analysis, respectively. In situ hybridization was performed
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23

Storch, Stephan, Bernd Kübler, Stefan Höning, Michael Ackmann, Jürgen Zapf, Werner Blum, and Thomas Braulke. "Transferrin binds insulin-like growth factors and affects binding properties of insulin-like growth factor binding protein-3." FEBS Letters 509, no. 3 (November 29, 2001): 395–98. http://dx.doi.org/10.1016/s0014-5793(01)03204-5.

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24

Morimoto, L. M. "Variation in Plasma Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3: Genetic Factors." Cancer Epidemiology Biomarkers & Prevention 14, no. 6 (June 1, 2005): 1394–401. http://dx.doi.org/10.1158/1055-9965.epi-04-0694.

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25

Weinzimer, Stuart A., Tara Beers Gibson, Paulo F. Collett-Solberg, Aruna Khare, Bingrong Liu, and Pinchas Cohen. "Transferrin Is an Insulin-Like Growth Factor-Binding Protein-3 Binding Protein1." Journal of Clinical Endocrinology & Metabolism 86, no. 4 (April 1, 2001): 1806–13. http://dx.doi.org/10.1210/jcem.86.4.7380.

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Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) possesses both growth-inhibitory and -potentiating effects on cells that are independent of IGF action and are mediated through specific IGFBP-3 binding proteins/receptors located at the cell membrane, cytosol, or nuclear compartments and in the extracellular matrix. We have here characterized transferrin (Tf) as one of these IGFBP-3 binding proteins. Human serum was fractionated over an IGFBP-3 affinity column, and a 70-kDa protein was eluted, sequenced, and identified (through database searching and Western immunoblot) as human Tf.
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26

Platz, Elizabeth A., Michael N. Pollak, Walter C. Willett, and Edward Giovannucci. "Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3." Journal of the American Academy of Dermatology 42, no. 6 (June 2000): 1003–7. http://dx.doi.org/10.1067/mjd.2000.103987.

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27

Duron, Emmanuelle, Benoît Funalot, Nadège Brunel, Joel Coste, Laurent Quinquis, Cécile Viollet, Joel Belmin, et al. "Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Protein-3 in Alzheimer's Disease." Journal of Clinical Endocrinology & Metabolism 97, no. 12 (December 1, 2012): 4673–81. http://dx.doi.org/10.1210/jc.2012-2063.

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28

Akmal, Sharifah Noor, Kankatsu Yun, Janet MacLay, Yoshikazu Higami, and Takayoshi Ikeda. "Insulin-like growth factor 2 and insulin-like growth factor binding protein 2 expression in hepatoblastoma." Human Pathology 26, no. 8 (August 1995): 846–51. http://dx.doi.org/10.1016/0046-8177(95)90005-5.

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29

Zhang, Jing, Fanghui Ding, Dan Jiao, Qiaozhi Li, and Hong Ma. "The Aberrant Expression of MicroRNA-125a-5p/IGF2BP3 Axis in Advanced Gastric Cancer and Its Clinical Relevance." Technology in Cancer Research & Treatment 19 (January 1, 2020): 153303382091733. http://dx.doi.org/10.1177/1533033820917332.

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RNA-binding proteins have been associated with cancer development. The overexpression of a well-known RNA-binding protein, insulin-like growth factor 2 messenger RNA–binding protein 3, has been identified as an indicator of poor prognosis in patients with various types of cancer. Although gastric cancer is a relatively frequent and potentially fatal malignancy, the mechanism by which insulin-like growth factor 2 messenger RNA–binding protein 3 regulates the development of this cancer remains unclear. This study aimed to investigate the role and regulatory mechanism of insulin-like growth facto
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30

Radulović, Ž. M., L. M. Porter, T. K. Kim, M. Bakshi, and A. Mulenga. "Amblyomma americanumtick saliva insulin-like growth factor binding protein-related protein 1 binds insulin but not insulin-like growth factors." Insect Molecular Biology 24, no. 5 (June 25, 2015): 539–50. http://dx.doi.org/10.1111/imb.12180.

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31

Weinzimer, S. A. "Transferrin Is an Insulin-Like Growth Factor-Binding Protein-3 Binding Protein." Journal of Clinical Endocrinology & Metabolism 86, no. 4 (April 1, 2001): 1806–13. http://dx.doi.org/10.1210/jc.86.4.1806.

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32

McCusker, R. H. "Controlling Insulin-Like Growth Factor Activity and the Modulation of Insulin-Like Growth Factor Binding Protein and Receptor Binding." Journal of Dairy Science 81, no. 6 (June 1998): 1790–800. http://dx.doi.org/10.3168/jds.s0022-0302(98)75748-0.

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33

Thomas, A. G., J. M. Holly, F. Taylor, and V. Miller. "Insulin like growth factor-I, insulin like growth factor binding protein-1, and insulin in childhood Crohn's disease." Gut 34, no. 7 (July 1, 1993): 944–47. http://dx.doi.org/10.1136/gut.34.7.944.

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34

Chen, DongFeng, Yingqian Li, and Eric Zhao. "Emerging roles for insulin-like growth factor binding protein like protein 1." Neural Regeneration Research 14, no. 2 (2019): 258. http://dx.doi.org/10.4103/1673-5374.244787.

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35

Ryu, Hye-Young, Hye-Jung Hwang, In-Hye Kim, Hong-Soo Ryu, and Taek-Jeong Nam. "Effects of glucose on metabolism and Insulin-like growth factor binding-3 expression in human fibroblasts." Journal of Life Science 17, no. 5 (May 25, 2007): 687–93. http://dx.doi.org/10.5352/jls.2007.17.5.687.

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36

HIZUKA, Naomi. "Serum Growth Hormone Binding Protein (GHBP)and Insulin-like Growth Factor Binding Protein (IGFBP)." Folia Endocrinologica Japonica 68, no. 10 (1992): 1073–81. http://dx.doi.org/10.1507/endocrine1927.68.10_1073.

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37

Barrios, V., J. Argente, J. Pozo, F. Hervás, M. T. Muñoz, J. I. Sánchez, and M. Hernández. "Insulin-Like Growth Factor I, Insulin-Like Growth Factor Binding Proteins, and Growth Hormone Binding Protein in Spanish Premature and Full-Term Newborns." Hormone Research 46, no. 3 (1996): 130–37. http://dx.doi.org/10.1159/000185009.

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38

Khosravi, M. Javad, Anastasia Diamandi, and Jehangir Mistry. "Immunoassay of insulin-like growth factor binding protein-1." Clinical Chemistry 43, no. 3 (March 1, 1997): 523–32. http://dx.doi.org/10.1093/clinchem/43.3.523.

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Abstract Accurate measurement of insulin-like growth factor (IGF) binding protein-1 (IGFBP-1) is important for precise definition of its physiological roles and potential diagnostic values. Because altered phosphorylation results in altered IGFBP-1 immunoreactivity, current assays may significantly underestimate or fail to detect physiological changes in the IGFBP-1 concentrations. We developed three ELISAs (ELISA 1–3) using a common capture but three different detection antibodies. IGFBP-1 in serum, synovial fluid (SF), cerebrospinal fluid (CSF), and amniotic fluid (AF) were measured before a
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39

Hwa, V. "The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily." Endocrine Reviews 20, no. 6 (December 1, 1999): 761–87. http://dx.doi.org/10.1210/er.20.6.761.

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40

Bach, Leon A., Ping Fu, and Zhiyong Yang. "Insulin-like growth factor-binding protein-6 and cancer." Clinical Science 124, no. 4 (October 31, 2012): 215–29. http://dx.doi.org/10.1042/cs20120343.

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The IGF (insulin-like growth factor) system is essential for physiological growth and it is also implicated in a number of diseases including cancer. IGF activity is modulated by a family of high-affinity IGF-binding proteins, and IGFBP-6 is distinctive because of its marked binding preference for IGF-II over IGF-I. A principal role for IGFBP-6 is inhibition of IGF-II actions, but recent studies have indicated that IGFBP-6 also has IGF-independent effects, including inhibition of angiogenesis and promotion of cancer cell migration. The present review briefly summarizes the IGF system in physio
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41

Hwa, Vivian, Youngman Oh, and Ron G. Rosenfeld. "The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily*." Endocrine Reviews 20, no. 6 (December 1, 1999): 761–87. http://dx.doi.org/10.1210/edrv.20.6.0382.

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42

Fowlkes, John L., Kathryn M. Thrailkill, Delila M. Serra, and Hideaki Nagase. "Insulin-like growth factor binding protein (IGFBP) substrate zymography." Endocrine 7, no. 1 (August 1997): 33–36. http://dx.doi.org/10.1007/bf02778059.

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43

Ranke, Michael B. "Insulin-like growth factor binding-protein-3 (IGFBP–3)." Best Practice & Research Clinical Endocrinology & Metabolism 29, no. 5 (October 2015): 701–11. http://dx.doi.org/10.1016/j.beem.2015.06.003.

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44

Marinaro, Joe A., Gary P. Jamieson, P. Mark Hogarth, and Leon A. Bach. "Differential dissociation kinetics explain the binding preference of insulin-like growth factor binding protein-6 for insulin-like growth factor-II over insulin-like growth factor-I." FEBS Letters 450, no. 3 (May 7, 1999): 240–44. http://dx.doi.org/10.1016/s0014-5793(99)00499-8.

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45

Aziz, Kamran Mahmood Ahmed. "Growth Hormone and Growth Retardation in Autoimmune Type-1 Diabetes. Insulin an Important Endocrine Growth Factor." Diabetes & Obesity International Journal 8, no. 1 (2023): 1–7. http://dx.doi.org/10.23880/doij-16000267.

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Growth hormone (GH) secretory alterations and dysregulations with insulin-like growth factor-I (IGF-1) axis among type-1 diabetic children and adolescents is well established. In this poorly controlled abnormal metabolic state, GH hypersecretion is observed with decreased levels of Insulin-like Growth Factors (IGFs), IGF binding proteins-3 (IGFBP-3), and growth hormone binding protein (GHBP). These all factors results in decreased growth velocity and growth retardation in type-1 diabetic children and adolescents. Insulin is the most important metabolic regulator of this system. Absolute insuli
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46

SNYDER, DAVID K., and DAVID R. CLEMMONS. "Insulin-Dependent Regulation of Insulin-Like Growth Factor-Binding Protein-1*." Journal of Clinical Endocrinology & Metabolism 71, no. 6 (December 1990): 1632–36. http://dx.doi.org/10.1210/jcem-71-6-1632.

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47

Cara, José F. "Insulin-Like Growth Factors, Insulin-Like Growth Factor Binding Proteins and Ovarian Androgen Production." Hormone Research 42, no. 1-2 (1994): 49–54. http://dx.doi.org/10.1159/000184145.

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48

Rosen, Clifford J. "Serum Insulin-like Growth Factors and Insulin-like Growth Factor-binding Proteins: Clinical Implications." Clinical Chemistry 45, no. 8 (August 1, 1999): 1384–90. http://dx.doi.org/10.1093/clinchem/45.8.1384.

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Abstract The last decade has been characterized by a major investigative thrust into the physiology of two unique but ubiquitous peptides, insulin-like growth factor (IGF)-I and IGF-II. The regulatory systems that control the tissue bioactivity of the IGFs have been delineated, and subcellular signaling mechanisms have been clarified. Clearly, both tissue and circulating growth factor concentrations are important in defining the relationship between IGF-I and cell activity. Bone, liver, and circulatory IGF-I have received the most attention by investigators, in part because of the ease of meas
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49

Roelen, Corné A., Hans P. Koppeschaar, Wouter R. de Vries, Pierre M. Zelissen, Yvonne E. Snel, Manorath E. Doerga, Jos H. Thijssen, and Rien A. Blankenstein. "High-affinity growth hormone binding protein, insulin-like growth factor I and insulin-like growth factor binding protein 3 in adults with growth hormone deficiency." European Journal of Endocrinology 135, no. 1 (July 1996): 82–86. http://dx.doi.org/10.1530/eje.0.1350082.

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Roelen CA, Koppeschaar HP, de Vries WR, Zelissen PM, Snel YE, Doerga ME, Thijssen JH, Blankenstein RA. High-affinity growth hormone binding protein, insulin-like growth factor I and insulin-like growth factor binding protein 3 in adults with growth hormone deficiency. Eur J Endocrinol 1996;135:82–6. ISSN 0804–4643 The high-affinity growth hormone binding protein (GHBP) circulates in human blood and represents the extracellular domain of the growth hormone (GH) receptor. The effects of GH deficiency on GHBP in adults are not clear. The aim of this study was to evaluate serum GHBP levels in adul
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50

Mofid, MohammadReza, Elham Jafari, Ali Gheysarzadeh, Karim Mahnam, Rezvan Shahmohammadi, Amir Ansari, and Hadi Bakhtyari. "In silico interaction of insulin-like growth factor binding protein 3 with insulin-like growth factor 1." Research in Pharmaceutical Sciences 13, no. 4 (2018): 332. http://dx.doi.org/10.4103/1735-5362.235160.

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