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Dissertations / Theses on the topic 'Insulin – Mechanism of action – Research'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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1

Carr, Kelley. "The Mechanism of the Prolonged Action of the Single-Chain Insulin, 70-01." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1511982660839103.

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2

Hall, David A. 1968. "Insulin-mimetic peroxovanadium compounds : synthesis, reactivity,and mechanism of action." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40355.

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The insulin mimetic bisperoxovanadium (bpV) complexes $ rm K sb2 lbrack VO(O sb2) sb2(OHpic) rbrack (OHpic = 3$-hydroxypicolinato) and $ rm K sb3 lbrack VO(O sb2) sb2(L$-$ rm L sp prime ) rbrack $ have been prepared and characterized, where L-$ rm L sp prime$ is a pyridinedicarboxylate (2,3-pdc, 2,4-pdc, and 2,5-pdc) or 3-acetatoxypicolinato (acetpic). The single crystal X-ray structures of three of the compounds have been determined: bpV(OHpic), bpV(2,4-pdc) and bpV(acetpic). These complexes, with the addition of one other previously reported unsubstituted bpV(pic) complex, comprise two serie

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3

Patel, Payal R. "A Role for CEACAM2 in Insulin Homeostasis and Action." University of Toledo Health Science Campus / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=mco1279320879.

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4

Gray, Alison Mary. "Studies on the efficacy and mechanism of action of traditional plant treatments for diabetes mellitus." Thesis, University of Ulster, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390120.

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5

Ghanem, Simona S. "A Role for CEACAM2 protein in Insulin Secretion, Clearance and Action." University of Toledo Health Science Campus / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=mco1491497714470047.

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6

Sampson, Louise E. "Investigations into the mechanism of action of tumour necrosis factor." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304660.

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7

Cadagan, David. "The molecular mechanism of insulin action in human theca and adipocyte cells in polycycstic ovarian syndrome." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/28112/.

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PCOS is one of the leading causes of infertility worldwide affecting 1 in 10 women of a reproductive age. One of the fundamental abnormalities in women with PCOS can be seen within hormonal irregularities, which may include hyperandrogenemia hyperinsulinemia and hyper secretion of luteinising hormone (LH); and it is hypothesised that a defect in steroid secreting ovarian theca cells is involved due to their contribution in non-PCOS hormonal synthesis. Hyperinsulinemia has been associated with hyper-androgenemia through in vitro studies of cultured PCOS theca, where it has been suggested that i

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8

Racoma, Ira Oliva. "Targeting Glioblastoma Survival Signaling: A Novel Mechanism of Action of Thymoquinone." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1369923513.

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9

Wright, David C. "The role of PLC, cPKC, L-type calcium channels and CAMKII in insulin stimulated glucose transport in skeletal muscle." Virtual Press, 2002. http://liblink.bsu.edu/uhtbin/catkey/1233206.

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10

Al-Share, Qusai Y. "Reduction of Hepatic CEACAM1 Levels: an Early Mechanism of Insulin Resistance Induced by High-Fat Diet." University of Toledo Health Science Campus / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=mco1201787222.

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11

Lohmeyer, Matthias. "The mechanism of action of antitumour lipid agents related to platelet-activating factor (PAF)." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319528.

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12

Baker, Richard Henry James. "An investigation into the efficacy and mechanism of action of insulin as an agent for the prevention or reduction of cutaneous scarring." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1444257/.

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Cutaneous scars can be itchy, painful, disfiguring, psychologically damaging and even pathological. The myofibroblast cell phenotype, that differentiates from fibroblasts during healing, is central to the formation of normal and pathological scars. However, there remains no reliably effective therapy that prevents scarring. This research explores the efficacy and mechanism of action of a potential new antiscarring agent - insulin. Research at the RAFT Institute of Plastic Surgery has demonstrated that insulin inhibits differentiation of skin fibroblasts into myofibroblasts in both human and mo

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13

Mosinski, J. David. "INSIGHTS TO THE MECHANISM OF TYPE 2 DIABETES REMISSION FOLLOWING ROUX-EN-Y GASTRIC BYPASS SURGERY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1460547248.

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14

Sayre, Brian L. "Oxytocin-induced cervical dilation in sheep: mechanism of action and potential use for nonsurgical artificial insemination." Diss., Virginia Tech, 1995. http://hdl.handle.net/10919/40251.

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15

Skeef, Noel Samuel. "Zinc inhibition of cell division : its relevance to cancer cells and possible mechanism of action." Thesis, Rhodes University, 1989. http://hdl.handle.net/10962/d1016266.

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A description of two techniques used extensively in this study namely cell counting with a "cell counting plate" and argentation TLC for the separation of ω -6 -fatty acids is given. Zn supplementation into GM of two malignant (BL-6 and Hep- 350) and a non-malignant (LLC-MK) cell line/s resulted in an increased uptake of Zn by the cells and progressively suppressed proliferation of particularly the malignant cells. Zn chelation by EDTA suppressed in vitro proliferation of all 3 cell line, this effect being more pronounced in the malignant cells. A dietary Zn deficiency resulted in alopecia in

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16

Brancato, Jennifer M. "Defining the Mechanism of Action of Bromodomain and Extraterminal Inhibitors in Triple-Negative Breast Cancers." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1522842642716411.

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17

Martis, Prithy Caroline. "RENCA macrobeads inhibit tumor cell growth via EGFR activation and regulation of MEF2 isoform expression." Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1597229612949836.

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18

Templin, Andrew Thomas. "Mechanisms of translational regulation in the pancreatic β cell stress response". Thesis, 2014. http://hdl.handle.net/1805/6162.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>The islet beta cell is unique in its ability to synthesize and secrete insulin for use in the body. A number of factors including proinflammatory cytokines, free fatty acids, and islet amyloid are known to cause beta cell stress. These factors lead to lipotoxic, inflammatory, and ER stress in the beta cell, contributing to beta cell dysfunction and death, and diabetes. While transcriptional responses to beta cell stress are well appreciated, relatively little is known regarding translational responses in the stressed beta cell. To st

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19

Gabbay, Robert Abraham. "Mechanism of insulin antagonism of cAMP-mediated hormone action." 1985. http://catalog.hathitrust.org/api/volumes/oclc/13014218.html.

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20

Mehdi, Mohamad Z. "Molecular mechanism of insulin-enhancing and -mimetic action of Vanadium compounds." Thèse, 2005. http://hdl.handle.net/1866/15354.

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21

Nelson, Renae. "Exploring the mechanism of action of spore photoproduct lyase." Thesis, 2014. http://hdl.handle.net/1805/4916.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Spore photoproduct lyase (SPL) is a radical SAM (S-adenosylmethionine) enzyme that is responsible for the repair of the DNA UV damage product 5-thyminyl-5,6-dihydrothymine (also called spore photoproduct, SP) in the early germination phase of bacterial endospores. SPL initiates the SP repair process using 5'-dA• (5'-deoxyadenosyl radical) generated by SAM cleavage to abstract the H6proR atom which results in a thymine allylic radical. These studies provide strong evidence that the TpT radical likely receives an H atom from an intrins

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22

Penque, Brent A. "Mechanisms of hexosamine-induced cholesterol accumulation and therapeutic actions of chromium." Thesis, 2014. http://hdl.handle.net/1805/3805.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Excess caloric intake and/or obesity currently remain the largest predisposing risk factors for the development of type 2 diabetes. Discerning the cellular and molecular mechanisms responsible and amendable to therapy represents a growing challenge in medicine. At a cellular level, increased activity of the hexosamine biosynthesis pathway (HBP), a sensor of excess energy status, has been suggested to promote the exacerbation of insulin resistance through increasing adipose tissue and skeletal muscle membrane cholesterol content. This

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23

Chang, Shan-Ching, and 張憲卿. "Research on Action Control of College Students: The Mechanism of Learning Motivation." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/40026468529298160926.

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碩士<br>國立成功大學<br>教育研究所<br>90<br>The purposes of this study had three folds: (1) to construct an indigenous College Students Action Control Scale based on the action control theory, by interview 27 college students in Taiwan. The psychometric properties were then investigated; (2) to investigate, after assigning success or failure condition to 113 college students, the differences of action-oriented, cognitive state-orientated, and emotional state-oriented subjects on working memory capacity, self-efficacy, and negative affective reaction by using 2 × 3 repeated measure design and (3) to test th

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24

Barrows, Douglas Walker. "The Regulation of PREX2 by Phosphorylation." Thesis, 2015. https://doi.org/10.7916/D8PN94WH.

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Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3)-dependent RAC exchanger 2 (PREX2) is a guanine nucleotide exchange factor (GEF) for the Ras-related C3 botulinum toxin substrate 1 (RAC1) GTPase. As a GEF, PREX2 facilitates the exchange of GDP for GTP on RAC1. GTP bound RAC1 then activates its downstream effectors, including p21-activated kinases (PAK). PREX2, RAC1, and PAK kinases all have key roles within the insulin signaling pathway. The insulin receptor is a tyrosine kinase that phosphorylates the insulin receptor substrate (IRS) family of adaptor proteins, leading to the activation

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25

Chang, Mei-Lin, and 張美琳. "An Action Research of Constructing a Chinese Remedial Instruction Supervising Mechanism for Disadvantaged Children." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/13987058038227874626.

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碩士<br>雲林科技大學<br>技術及職業教育研究所碩士班<br>97<br>The present action study targeted on five disadvantaged second-grade students whose Chinese grades were C or D; sixteen weeks of remedial instruction was performed. Accordingly, adopting qualitative research approach, this research utilized classroom observation, assisting teachers’ teaching records, supervising reflection records, personal supervision, group supervision, and interview data for feedback. Moreover, through incessant observing, supervising, and interactive discussing with the assisting teachers, the present research discovered problems, sou

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26

Chen, Yen-Iou, and 陳彥佑. "Feed-forward and Feed-back Mechanism of Virtual Newsroom Operations Management: Action Research Perspective and Implementation." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/32n778.

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碩士<br>國立交通大學<br>傳播研究所<br>92<br>Computers, networks, and digital techniques have brought new development opportunities for the media industries, and have gained much attention from practicing media managers and communication academic researchers. Media managers utilize Information Technology to improve media production performance, while communication researchers focus on observing interactions between online community members. In this article, the author stands on media ecology perspective, which has noted the importance of feed-forward and feed-back mechanism in maintaining systems developing

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27

TSAI, SHING-LING, and 蔡幸玲. "An Action Research of Applying Instant Peer Assessment Mechanism in a Vocational High School Beverage Modulation Course." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/9y99ra.

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碩士<br>國立臺北科技大學<br>技術及職業教育研究所<br>107<br>The purpose of this action research study aimed to analyze the outcome of students’ learning achievement, and the difficulties and countermeasures after implementing instant peer assessment mechanism to teach a beverage modulation course in a vocational high school. Twenty-nine eleventh grade students from the Department of Restaurant Skills undergone a nine-week intervention, with a total of 18 sessions. The results were as follows: In terms of curriculum design, the difficulties and attempted solutions were: (1) The curriculum was condensed; the teachin

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28

Zwi, Leon Jonathan. "The Mechanism of the anti-tumour action of flavone acetic acid and its xanthenone acetic acid analogues." 1992. http://hdl.handle.net/2292/3356.

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The search for new compounds with anti-tumour activity is driven by the high mortality from disseminated visceral carcinomas for which few effective treatments exist. The experimental agent flavone acetic acid (FAA) has stimulated interest because of its broad spectrum of activity against solid tumours in mice. This remarkable activity spectrum suggested an unusual mechanism of action. The aim of the thesis was to elucidate the mechanism of action of FAA and its analogues in mouse tumours, particularly the rapid induction of haemorrhagic necrosis Light and electron microscopic studies of Colon

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29

Yu, Chia-Chi, and 游家綺. "Action Research of the Impact of STEM-based Mechanism Toy Hands-onActivity on Junior High School Students’ Mechanical Aptitude." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/ur2m9t.

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碩士<br>國立臺灣師範大學<br>科技應用與人力資源發展學系<br>105<br>The aim of this action research is to solve the problem that students seldom learn by integrating and applying the relevant knowledge of other subjects in the implementation activities. The researcher developed a STEM-based mechanism toy hands-on activity, then discussed about the impact of the activity on their mechanical aptitude. This result can be used as a valuable reference for junior-high-school technology curriculum in the future. This study was an action research conducted with a quasi-experimental method. The ten-week activity was carried out

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30

Hunag, Ching-Nan, and 黃景南. "An Action Research of the Interactive Mechanism between Urban Universities and Neighbouring Communities – A Case Study on Kaohsiung Medical University and An-Sheng Neighbourhood." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/19274540403463334864.

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碩士<br>樹德科技大學<br>建築與古蹟維護研究所<br>91<br>The main purpose of this research was to explore the interaction between urban universities and neighbouring communities by participating in the informal organization named “CCOT (Creative Campus Organizing Team)” of Kaohsiung Medical University. CCOT was also the platform between the interaction of the university and the community during action research process. The team operational mechanism, the interactive relation, and the effects were further analyzed after suffering the circulating process of friction, conflict, cold war, reconciliation, and cooperat

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31

Brown, Shauna L. "Investigation into the mechanism of action and biological role of Saccharomyces cerevisiae mannoproteins which reduce visible haziness in white wine." 2003. http://hdl.handle.net/2440/37874.

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Heat induced protein haze is a common problem in white wine. Grape derived pathogenesis related proteins slowly denature and aggregate during wine storage and this gives rise to light dispersing haze. Protein haze formation is currently prevented by removing proteins using bentonite, an aluminium silicate clay, but this method has drawbacks. A potential alternative or complementary method is the use of haze protective factors ( HPF ), specific mannoproteins from Saccharomyces cerevisiae that visually reduce protein haze. Hpf1p was originally isolated from Muscat Gordo Blanco wine and Hpf2p fro

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32

Martin, Holly René. "Mechanism of Transformation and Therapeutic Targets for Hematological Neoplasms Harboring Oncogenic KIT Mutation." Thesis, 2014. http://hdl.handle.net/1805/5503.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Gain-of-function mutations in the KIT receptor tyrosine kinase have been associated with highly malignant human neoplasms. In particular, an acquired somatic mutation at codon 816 in the second catalytic domain of KIT involving an aspartic acid to valine substitution is found in patients with systemic mastocytosis (SM) and acute myeloid leukemia (AML). The presence of this mutation in SM and AML is associated with poor prognosis and overall survival. This mutation changes the conformation of the KIT receptor resulting in altered subs

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33

Kabamba, Tshibangu Taiddyslas. "The psycho-social challenges facing HIV/AIDS lay counsellors at a community-based voluntary counselling and testing site in Tshwane." Diss., 2009. http://hdl.handle.net/10500/3385.

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This study focuses on the psycho-social challenges faced by HIV/AIDS lay counsellors at a Voluntary Counselling and Testing (VCT) site in Tshwane, South Africa. A qualitative approach was employed by using semi-structured interviews with open-ended questions to obtain information from four lay counsellors, who provide pre- and post-test counselling at a VCT site. The results indicate that the management of clients’ emotions and needs pose enormous challenges to HIV/AIDS lay counsellors who do not receive any formal psycho-social support at VCT sites. The research participants in this study res

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