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Relevant bibliographies by topics / Insulin metabolism / Dissertations / Theses

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Dissertations / Theses on the topic 'Insulin metabolism'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Vidal, Alabró Anna. "Estudi de l’activació de la glucocinasa (GKA456V) en fetge perivenós." Doctoral thesis, Universitat de Barcelona, 2011. http://hdl.handle.net/10803/32022.

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La GK és clau en la regulació del metabolisme glucídic tant per la seva funció al pàncrees en què determina la secreció d’insulina, com per la seva funció al fetge on controla les vies d’utilització i d’emmagatzematge de glucosa. Per aquest motiu és una bona diana per a la teràpia de la diabetis, i diverses companyies farmacèutiques estan desenvolupant activadors sintètics de la GK (GKA) pel tractament de la diabetis de tipus 2. Els estudis de GKAs existents avaluen l’activació de la GK a nivell sistèmic i no es coneixen els seus efectes específis sobre la GK al fetge. Per indagar-los, com q

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2

Collison, Mary Williamson. "Insulin signalling in insulin resistance and cardiovascular disease syndromes." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366184.

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3

Kershner, David. "Oral Glucose Insulin Secretion Test for Identifying Patients with Insulin Resistance." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/5634.

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Insulin resistance is an increasing public health issue with the current literature, suggesting reduced sensitivity of insulin leads to adult onset diabetes and associated downstream pathologies that reduce life expectancy. The main objectives of this study were to evaluate the ability of the Oral Glucose Insulin Secretion Test (OGIST) to identify insulin resistance and examine differences in the insulin sensitivity based on gender, age, and ethnicity. This study was supported by the insulin resistance theory which focuses on the reduced ability of insulin to bind to the cellular insulin recep

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4

Mashhedi, Haider. "Implicating insulin in neoplastic growth and metabolism." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104681.

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In view of accumulating evidence that links obesity to increased cancer burden, there is interest in delineating the mechanisms by which obesity influences neoplastic growth. Increased insulin levels are commonly associated with obesity or ‘the metabolic syndrome' and thus the insulin receptor has been viewed as a potentially important molecular target for the treatment of certain cancers. To study the effects of insulin signaling attenuation on the growth of the experimental insulin-responsive mouse 4T1 breast cancer cells in vivo, we compared the effects of alloxan-induced insulin deficiency

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5

Shmueli, Ehoud. "Glucose metabolism and insulin resistance in cirrhosis." Thesis, University of Newcastle Upon Tyne, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308777.

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6

Laberge, Marie-Kristine. "Nck1 is required for ER stress-induced insulin resistance and regulation of IRS1-dependent insulin signalling." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111950.

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Activation of the Unfolded Protein Response (UPR) following stress in the Endoplasmic Reticulum (ER) is an important mechanism by which obesity results in insulin resistance and type II diabetes. We uncovered a role for the adaptor protein Nck in modulating the UPR. In this study, we report that obese Nck1-/- mice, which show lower levels of UPR in liver and adipose tissue, present improved insulin signalling in these tissues. We established that the effect of Nck1 is cell autonomous by showing that HepG2 cells treated with Nck1 siRNA have reduced ER stress-induced UPR and Insulin Receptor Sub

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7

Sanderson, Alison Louise. "Regulation of skeletal muscle metabolism." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318615.

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8

Field, Polly Ann. "The effects of insulin resistance on chylomicron metabolism." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302120.

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9

DeAngelis, Anthony Michael. "CEACAM1 : a link between insulin and lipid metabolism." Connect to full text in OhioLINK ETD Center, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1243943993.

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Dissertation (Ph.D.)--University of Toledo, 2009.<br>"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biomedical Sciences." Title from title page of PDF document. Bibliography: p. 57-61, p. 20-145.

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10

Denti, Paolo. "Nonlinear Mixed-Effects Modelling of Glucose-Insulin Metabolism." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3426016.

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Diabetes mellitus is not only a very serious disease, causing discomfort and pain to millions across the world, but with the aging of the population and the prevalence of a sedentary lifestyle, it is assuming the proportion of a real epidemic, becoming a public health and social emergency. In answer to this call, research on diabetes has been intensely carried out in the past decades and the knowledge and understanding of its etiology have been significantly improved. However, investigation is still ongoing, many important questions are still unanswered, and the causes eliciting the pathogenes

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11

Nygren, Jonas. "The sites and mechanisms of postoperative insulin resistance /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2695-6.

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12

Yang, Yan. "CEACAM1: A Molecular Link Between Fat Metabolism and Insulin Clearance." University of Toledo Health Science Campus / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=mco1115060085.

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13

Wang, Mengjie. "Brain Insulin-Like Growth Factor 1 Receptor and Insulin Receptor in Metabolism and Reproduction." University of Toledo Health Science Campus / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=mco1564676824418256.

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14

Busquets, Figueras Oriol. "Estudi del paper de les proteïnes JNK en el desenvolupament de trastorns metabòlics i cognitius = Study on the role of the JNK proteins in the development of metabolic and cognitive disruptions." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/668381.

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Molts estudis previs sobre el paper de les cinases c-JUN N-terminal (JNK) no tenien en compte les diferències existents en l’activitat de cadascuna de les isoformes. Això va provocar que les propostes terapèutiques que regulaven les JNK de manera inespecífica es trobessin amb problemes importants. L’objectiu de la present tesi doctoral era ampliar els coneixements que es tenen actualment sobre el paper individual de les isoformes de les JNK i, avaluar qualsevol interès terapèutic que pugui derivar de la seva modulació per a l’epilèpsia del lòbul temporal i afectacions cognitives derivades del

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15

Parpal, Santiago. "Mechanisms of insulin signaling and the role of caveolae /." Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/med684s.pdf.

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16

Dai, Tong. "Differential Role of CEACAM Proteins in Regulating Insulin Metabolism." University of Toledo Health Science Campus / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=mco1139336269.

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17

Dai, Tong. "Differential role of CEACAM1 and CEACAM2 in insulin metabolism." Connect to full-text via OhioLINK ETD Center, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1139336269.

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Thesis (Ph.D.)--Medical University of Ohio, 2004.<br>"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Medical Sciences." Major advisor: Sonia M. Najjar. Includes abstract. Document formatted into pages: v, 217 p. Title from title page of PDF document. Bibliography: pages 158-216.

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18

Tan, Kathryn Choon Beng. "Postprandial lipoprotein metabolism in non-insulin-dependent diabetes mellitus." Thesis, Cardiff University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323795.

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19

Aiston, Susan Michelle. "Regulation of hepatic glucose metabolism by leptin and insulin." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341441.

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20

Tyler-Rubinstein, Nadia. "The role of insulin receptor substrate signalling in metabolism." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/54894.

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Background/Aims: In order to mediate a diverse range of growth and metabolic functions, insulin receptor substrate (IRS) proteins recruit a complex network of intracellular signalling molecules including PI3-kinase and the Grb2 adaptor protein. These studies proposed to answer the question to what extent are the different phenotypes observed in Irs1 and Irs2 knockout mice due to the loss of the whole protein or due to the loss of specific signalling interactions between IRS proteins and either p85 (the regulatory subunit of PI3K) or Grb2? Determining which interactions mediate which biological

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21

Potts, Jennifer Lucy. "Lipoprotein metabolism in human adipose tissue." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334875.

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22

Needham, Elise. "Personalised phosphoproteomics of skeletal muscle metabolism." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/28191.

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Protein phosphorylation dynamically integrates environmental and intracellular information to control virtually all biological processes. Challenges in determining the upstream regulation and downstream effects of phosphorylation obscures our functional understanding of cellular communication. In this thesis, I developed approaches to contextualise and prioritise phosphorylation events, focusing on the dynamic regulation of skeletal muscle metabolism by insulin and exercise. I measured phosphoproteomes of an in vitro panel of exercise-like stimuli to dissect upstream influences on exercise sig

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23

Strömmer, Lisa. "Insulin action and secretion after surgical trauma : an experimental study in the rat /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4295-1/.

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24

Soop, Mattias. "Effects of perioperative nutrition on insulin action in postoperative metabolism /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-529-8/.

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25

Yang, Yan. "CEACAM1 : a molecular link between fat metabolism and insulin clearance." Connect to full-text via OhioLINK ETD Center, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1115060085.

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Thesis (Ph.D.)--Medical College of Ohio, 2004.<br>In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Medical Sciences. Major advisor: Sonia Najjar. Includes abstract. Document formatted into pages: v, 167 p. Bibliography: pages 117-165.

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26

Loos, Caroline Margot Marcelle. "THE IMPACT OF INSULIN DYSREGULATION ON PROTEIN METABOLISM IN HORSES." UKnowledge, 2018. https://uknowledge.uky.edu/animalsci_etds/83.

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Insulin plays a vital role in whole-body metabolism and provides a major anabolic stimulus for cellular signaling pathways, including those involved in the metabolism of glucose and protein. Consequently, insulin dysregulation (ID) is known to alter molecular signal transduction in insulin-sensitive tissues such as skeletal muscle, thereby disrupting glucose metabolism and compromising protein synthetic capacity. Our first objective was to induce ID in healthy horses by administering dexamethasone (DEX), a potent glucocorticoid, for 21 days. We evaluated the effects on insulin-stimulated muscl

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27

Cazzo, Everton 1979. "Impacto do Bypass Gastrojejunal em Y de Roux sobre a Síndrome Metabólica e seus componentes : análise de resultados." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309054.

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Orientador: Elinton Adami Chaim<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-23T03:30:35Z (GMT). No. of bitstreams: 1 Cazzo_Everton_M.pdf: 2625294 bytes, checksum: 2f57e795cce0f0c4c5a74d56bad92609 (MD5) Previous issue date: 2013<br>Resumo: A Síndrome Metabólica é um conjunto de fatores interconectados que elevam diretamente o risco de doenças cardiovasculares e diabetes mellitus tipo II. Estes fatores são alterações no metabolismo glicídico, elevação da pressão arterial, níveis elevados de triglicerídeos e

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28

Reis, Sabrina Karen 1989. "Efeitos da suplementação com l-glutamina nos níveis séricos de hormônios relacionados ao metabolismo energético em indivíduos com sobrepeso e obesidade." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/244476.

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Orientador: Patricia de Oliveira Prada<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Aplicadas<br>Made available in DSpace on 2018-08-25T21:25:58Z (GMT). No. of bitstreams: 1 Reis_SabrinaKaren_M.pdf: 2044889 bytes, checksum: 02eeb1437ecda9df9b2500ae61a282e8 (MD5) Previous issue date: 2014<br>Resumo: Obesidade está associada à inflamação crônica de baixo grau e ao desenvolvimento da resistência à insulina. A suplementação com L-glutamina tem sido utilizada para reduzir a inflamação em pacientes críticos. No entanto, os efeitos da suplementação deste amin

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29

Gil, Paulo César Nunes. "Uso da maltodextrina na substituição do amido em dieta para eqüinos." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/10/10135/tde-21092010-133608/.

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O objetivo deste estudo foi determinar os efeitos da suplementação com maltodextrina, na substituição do amido na dieta de eqüinos avaliando a digestibilidade aparente total da matéria seca e nutriente e as diferenças nas respostas glicêmicas e insulinêmicas das dietas determinadas. Foram utilizados quatro eqüinos fêmeas com idade aproximada de 30 meses, peso médio de 400 kg, pertencentes ao rebanho da USP. Os animais foram imunizados contra tétano, vermifugados e pulverizados contra ectoparasitos. A dieta foi composta por 50% de concentrado e 50% de volumoso, formulada para atender as exigê

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30

Rincón, Viatela Jorge E. "Regulation of glucose transport and insulin-stimulated glut4 translocation in skeletal muscle /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3297-2/.

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31

Kamel, Ashraf Fawzy. "Insulin and growth hormone : regulation of adipocyte metabolism during infancy and childhood /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3485-1/.

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32

Osei, Michael. "A study of dietary fat metabolism in healthy and insulin resistant subjects." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708531.

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33

Nesin, April Erwin. "Relationship between Emotional Competence and Metabolic Control in Adolescents with Insulin Dependent Diabetes Mellitus (IDDM)." Fogler Library, University of Maine, 2004. http://www.library.umaine.edu/theses/pdf/NesinAE2004.pdf.

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34

Lemley, Caleb Owens. "Alterations in progesterone catabolic enzymes by insulin." Morgantown, W. Va. : [West Virginia University Libraries], 2007. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5286.

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35

Isaksson, Bengt. "Insulin resistance in pancreatic cancer /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-493-3/.

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36

Yamamoto, Daniel L. "Adrenergic signaling in insulin-sensitive tissues." Doctoral thesis, Stockholm : Wenner-Gren Institute for Experimental Biology, Stockholm University, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-6668.

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37

Forbes, Johnathon. "Hormonal Regulation of Glucose Kinetics in Rainbow Trout: Effects of Insulin and Glucagon." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39050.

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Mammals and fish rely on hormones to regulate blood glucose levels. The two major glucose regulating hormones are insulin and glucagon. Literature on mammalian insulin and glucagon is quite extensive, however, there is limited information on how these hormones regulate blood glucose levels in fish. The material available for fish mostly pertains to changes in glucose concentration and gene expression of enzymes, but there is no information on the direct influence they have on glucose kinetics. Therefore, the main goal of my thesis is to measure the change in hepatic glucose production and gluc

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38

Kim, Tae-gyu. "Effects of #beta#-casomorphins on metabolism of dairy cows." Thesis, University of Glasgow, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301620.

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39

Cambron, Liz Doralyn. "Factors Affecting Metabolism During Non-Feeding Stages in Insects." Diss., North Dakota State University, 2020. https://hdl.handle.net/10365/31868.

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Although feeding is important for optimal development and growth in insects, there are several points during the insect life cycle that are non-feeding: metamorphosis, pupation, and overwintering. Non-feeding periods also occur in response to internal cues, such as feedback from nutrient thresholds and immune responses being activated. Additionally, as an insect goes through different developmental stages, its nutritional requirements change in response to or in preparation for non-feeding periods. Most physiological responses like feeding are regulated through an interconnection of pathways,

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40

Gomez, Cristina Alexandra Silva. "Tratamento ortodôntico em pacientes diabéticos." Master's thesis, [s.n.], 2015. http://hdl.handle.net/10284/4748.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária<br>A diabetes mellitus é um síndrome ou distúrbio na homeostase da glicose causada por uma deficiência de insulina ou por uma ação anormal desta no metabolismo de hidratos de carbono, proteínas e gordura. É a desordem endrocrino-metabólica mais comum na infância e adolescência, com consequências no desenvolvimento físico e emocional dos seus portadores. (Meyle et alii, 2001) O objetivo do presente trabalho é caracterizar o paciente diabé

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41

Oliveira, Neto Jessika Geisebel. "Impacto da suplementação materna com extrato aquoso de canela durante a lactação sobre a homeostase energética da prole adulta." Niterói, 2017. https://app.uff.br/riuff/handle/1/3779.

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Submitted by Biblioteca do Instituto Biomédico BIB (uffbib@gmail.com) on 2017-06-05T16:57:34Z No. of bitstreams: 1 Dissertação_mestrado-versão_final-_Jessika_Geisebel.pdf: 1194239 bytes, checksum: b59363ae595a444e379ef361c1b537c2 (MD5)<br>Made available in DSpace on 2017-06-05T16:57:34Z (GMT). No. of bitstreams: 1 Dissertação_mestrado-versão_final-_Jessika_Geisebel.pdf: 1194239 bytes, checksum: b59363ae595a444e379ef361c1b537c2 (MD5)<br>A programação metabólica ocorre quando insultos promovem alterações adaptativas nos períodos críticos do desenvolvimento e alteram as funções endócrino-metab

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42

Bevan, Samantha J. "Factors influencing the sensitivity of skeletal muscle glucose metabolism to insulin." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305419.

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43

Glynn, M. J. "The implications of insulin and protein metabolism for clinical nutritional support." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599445.

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44

Kapan, Neval. "Regulation of insulin producing cells, stress responses and metabolism in Drosophila." Doctoral thesis, Stockholms universitet, Zoologiska institutionen, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-80518.

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In Drosophila, neuropeptides have regulatory roles in development, growth, metabolism and reproduction. This study focused on GABA and the neuropeptides Drosophila tachykinin (DTK), short neuropeptide F (sNPF), adipokinetic hormone (AKH), corazonin (CRZ) and Drosophila insulin-like peptides (DILPs) as possible regulators of metabolic stress responses and homeostasis. We showed that metabotropic GABAB receptors (GBRs) are expressed on brain insulin producing cells (IPCs), suggesting an inhibitory regulation of these cells by GABA. Knockdown of GBR on IPCs shortened lifespan and stress resistanc

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45

Sweeney, Gary. "Protein kinase C isoforms : insulin signalling, cyclic amp metabolism and diabetes." Thesis, University of Glasgow, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306884.

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46

Pennington, S. R. "The effects of insulin on phosphoinositide metabolism in isolated fat cells." Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382660.

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47

Nixon, Mark. "Interactions between glucocorticoid metabolism and inflammation in obesity and insulin resistance." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5593.

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Inflammation plays a key role in the underlying pathogenesis of obesity and its associated health risks, with increased markers of inflammation evident in both liver and adipose tissue. In parallel, there is dysregulation of glucocorticoid metabolism in obesity, with increased adipose levels of the glucocorticoid-regenerating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and increased hepatic levels of 5α-reductase type 1 (5αR1), which catalyses the reduction of glucocorticoids. Both the mechanisms and consequences of this glucocorticoid metabolism dysregulation remain unclear, howe

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48

Dean, John Duncan. "Lipoprotein metabolism and macrovascular disease in non-insulin dependent diabetes mellitus." Thesis, University of Leicester, 1993. http://hdl.handle.net/2381/34322.

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A case control study comparing fasting lipid and apolipoprotein concentrations in NIDDM patients and normal control subjects matched for age, sex and body mass, reveals abnormalities of high density lipoproteins and apolipoprotein B containing lipoproteins despite hypoglycaemic therapy. HDL cholesterol concentration is reduced in these NIDDM patients, whilst apolipoprotein concentrations are similar to the controls. Therefore HDL particles may be cholesterol poor, possibly reflecting reduced reverse cholesterol transport. LDL cholesterol concentration may also be reduced in these patients whil

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49

Penteado, Érica 1973. "Tratamento com topiramato melhora a sensibilidade hipotalâmica à insulina em camundongos obesos." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311559.

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Orientador: Patrícia de Oliveira Prada<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-19T14:40:09Z (GMT). No. of bitstreams: 1 Penteado_Erica_M.pdf: 2591549 bytes, checksum: 18851851d9a1a75cb2bd1ef2c4f7cb86 (MD5) Previous issue date: 2011<br>Resumo: O topiramato (TPM) é utilizado atualmente no tratamento da epilepsia e da enxaqueca por ser antagonista do receptor AMPA/KA e por aumentar o receptor de GABA, desencadeando a estabilização dos canais de sódio e cálcio. O efeito colateral mais conhecido dessa drog

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50

Frias, Flávia de Toledo. "Papel dos microRNAs (miR-1, miR-133, miR-206, miR-208b, miR-499 e miR-223) no músculo esquelético de camundongos C57BL/6 durante o estado de resistência à insulina." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-12092016-085246/.

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No músculo esquelético (ME) resistente à insulina, a disponibilidade elevada de ácidos graxos (AGs) livres observada na obesidade provoca alterações na função mitocondrial. Sendo os microRNAs (miRs) moléculas recentemente apontadas na regulação gênica de vias metabólicas, nosso objetivo foi investigar em ME de camundongos com resistência à insulina (RI) induzida por dieta hiperlipídica durante 8 semanas, tratados com fenofibrato (CF e HF) ou metilcelulose (veículo; grupos C e H) nas duas semanas antes do sacrifício, se os miRs-1a, 133a/b, 206, 208b, 499 e miR-223 participam da patogênese da RI

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