Relevant bibliographies by topics / Interaction Env

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Interaction Env'

Author: Grafiati
Published: 4 June 2021
Last updated: 10 February 2022

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Journal articles on the topic "Interaction Env"

1

Lavillette, Dimitri, Bertrand Boson, Stephen J. Russell, and François-Loı̈c Cosset. "Activation of Membrane Fusion by Murine Leukemia Viruses Is Controlled in cis or in trans by Interactions between the Receptor-Binding Domain and a Conserved Disulfide Loop of the Carboxy Terminus of the Surface Glycoprotein." Journal of Virology 75, no. 8 (April 15, 2001): 3685–95. http://dx.doi.org/10.1128/jvi.75.8.3685-3695.2001.

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ABSTRACT Cell entry of retroviruses is initiated by the recognition of cellular receptors and the subsequent membrane fusion between viral and cellular membranes. These two steps are mediated by the surface (SU) and transmembrane (TM) subunits of the retroviral envelope glycoprotein (Env), respectively. Determinants regulating membrane fusion have been described throughout SU and TM, but the processes coupling receptor recognition to fusion are still elusive. Here we establish that a critical interaction is formed between the receptor-binding domain (RBD) and the major disulfide loop of the carboxy-terminal domain (C domain) of the murine leukemia virus SU. Receptor binding causes an alteration of this interaction and, in turn, promotes further events of Env fusion activation. We characterize mutations which, by lowering this interaction and reducing the compatibility between the RBD and C domains of Env glycoprotein chimeras, affect both Env fusogenicity and sensitivity to receptor interference. Additionally, we demonstrate that suboptimal interactions in such mutant Env proteins can be compensated in trans by soluble RBDs in a manner that depends on their compatibility with the C domain. Our results therefore indicate that RBD/C domain interactions may occur in cis, via the proper RBD of the viral Env itself, or in trans, via a distinct RBD expressed by virion-free Env glycoproteins expressed endogenously by the infected cells or provided by neighboring Env trimers.
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Vincent, Martin J., Lawrence R. Melsen, Annelet S. Martin, and Richard W. Compans. "Intracellular Interaction of Simian Immunodeficiency Virus Gag and Env Proteins." Journal of Virology 73, no. 10 (October 1, 1999): 8138–44. http://dx.doi.org/10.1128/jvi.73.10.8138-8144.1999.

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ABSTRACT In polarized epithelial cells, the assembly and release of human immunodeficiency virus type 1 (HIV-1) occur at the basolateral side of the plasma membrane, and the site of assembly is determined by the site of expression of the Env protein. In order to investigate whether the expression of the Env proteins exclusively in the endoplasmic reticulum (ER) can alter the site of virus assembly, we coexpressed the simian immunodeficiency virus (SIV) Gag protein and mutant SIV Env proteins having an ER retrieval signal (KKXX motif). In cells expressing the wild-type (wt) Env protein or coexpressing Env and Gag proteins, the Env protein was processed into the surface (SU) and transmembrane (TM) proteins. In contrast, in cells expressing the mutant Env proteins alone or in combination with Gag, the Env proteins were retrieved to the ER and were not proteolytically processed. Coexpression of the Gag and ER-retained mutant Env proteins resulted in a transient decrease in the release of the Gag protein into the medium, suggesting an interaction between the Gag and ER-retrieved Env proteins. Using saponin-permeabilized cells coexpressing Gag and Env proteins, we obtained further evidence for Env-Gag interaction. A monoclonal antibody specific to the SIV Gag protein was found to coimmunoprecipitate both the Gag and Env proteins. The interaction was specific, as coexpressed SIV Env proteins without the cytoplasmic tail or a chimeric HIV-1 Env proteins with the CD4 cytoplasmic tail were not coimmunoprecipitated by the Gag-specific antibody. Electron microscopic analyses indicated that assembly of virus particles occurred only at the surfaces of cells in which the Gag protein was coexpressed with either the wt or ER-retrieved mutant Env protein. These data indicate that although the Env and Gag proteins interact intracellularly, the site of assembly of SIV is not redirected to an intracellular organelle by the retrieval of the Env protein to the ER.
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Ugarte, M. D., T. Goicoa, J. Etxeberria, and A. F. Militino. "Testing for space-time interaction in conditional autoregressive models." Environmetrics 23, no. 1 (July 28, 2011): 3–11. http://dx.doi.org/10.1002/env.1126.

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Murphy, R. Elliot, Alexandra B. Samal, Gunnar Eastep, Ruba H. Ghanam, Peter E. Prevelige, and Jamil S. Saad. "Structural Basis for Env Incorporation into HIV-1 Particles." Proceedings 50, no. 1 (July 2, 2020): 114. http://dx.doi.org/10.3390/proceedings2020050114.

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During the late phase of the HIV-1 replication cycle, the Gag polyproteins are transported to the plasma membrane (PM) for assembly. Gag targeting and assembly on the PM is dependent on interactions between its matrix (MA) domain and phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2). Subsequent to Gag assembly, the envelope (Env) protein is recruited to the PM for incorporation into virus particles. Evidence suggests that the incorporation of the Env protein is mediated by interactions between the MA domain of Gag and the cytoplasmic tail of the gp41 subunit of Env (gp41CT), a mechanism that remains to be elucidated. Trimerization of the MA domain of Gag appears to be an obligatory step for this interaction. The interplay between gp41CT, the MA trimer, and the membrane has yet to be determined. Our lab has pioneered methods and approaches to investigate, at the molecular level, how the retroviral MA domains of Gag interact with membranes, a key requirement for understanding the Gag assembly and Env incorporation. Herein, we devised innovative approaches that will enable the structural characterization of the gp41CT–MA–membrane interactions. We employed structural biology (NMR and cryo-electron microscopy, biophysical methods, and biochemical tools to generate a macromolecular picture of how the MA domain of Gag binds to the membrane and how it interacts with gp41CT. To this end, we: (i) determined the three-dimensional structure of HIV-1 gp41CT and characterized its interaction with the membrane, (ii) engineered trimeric constructs of gp41CT and the MA to recapitulate the native and functional states of the proteins, and (iii) utilized membrane nanodisc technology to anchor the MA and gp41CT proteins. Our studies will allow for a detailed structural characterization of the gp41CT–MA–membrane interactions, which will advance our knowledge of HIV-1 Gag assembly and Env incorporation.
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Douagi, Iyadh, Mattias N. E. Forsell, Christopher Sundling, Sijy O'Dell, Yu Feng, Pia Dosenovic, Yuxing Li, et al. "Influence of Novel CD4 Binding-Defective HIV-1 Envelope Glycoprotein Immunogens on Neutralizing Antibody and T-Cell Responses in Nonhuman Primates." Journal of Virology 84, no. 4 (December 2, 2009): 1683–95. http://dx.doi.org/10.1128/jvi.01896-09.

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ABSTRACT The high-affinity in vivo interaction between soluble HIV-1 envelope glycoprotein (Env) immunogens and primate CD4 results in conformational changes that alter the immunogenicity of the gp120 subunit. Because the conserved binding site on gp120 that directly interacts with CD4 is a major vaccine target, we sought to better understand the impact of in vivo Env-CD4 interactions during vaccination. Rhesus macaques were immunized with soluble wild-type (WT) Env trimers, and two trimer immunogens rendered CD4 binding defective through distinct mechanisms. In one variant, we introduced a mutation that directly disrupts CD4 binding (368D/R). In the second variant, we introduced three mutations (423I/M, 425N/K, and 431G/E) that disrupt CD4 binding indirectly by altering a gp120 subdomain known as the bridging sheet, which is required for locking Env into a stable interaction with CD4. Following immunization, Env-specific binding antibody titers and frequencies of Env-specific memory B cells were comparable between the groups. However, the quality of neutralizing antibody responses induced by the variants was distinctly different. Antibodies against the coreceptor binding site were elicited by WT trimers but not the CD4 binding-defective trimers, while antibodies against the CD4 binding site were elicited by the WT and the 423I/M, 425N/K, and 431G/E trimers but not the 368D/R trimers. Furthermore, the CD4 binding-defective trimer variants stimulated less potent neutralizing antibody activity against neutralization-sensitive viruses than WT trimers. Overall, our studies do not reveal any potential negative effects imparted by the in vivo interaction between WT Env and primate CD4 on the generation of functional T cells and antibodies in response to soluble Env vaccination.
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Estrella-Luna, Neenah. "Public Participation and Communicative Interaction: The Structural Mechanisms of Institutional Bias." Environmental Justice 3, no. 4 (December 2010): 135–40. http://dx.doi.org/10.1089/env.2010.0009.

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Poon, Selina, Carlos G. Moscoso, Li Xing, Elaine Kan, Yide Sun, Prasanna R. Kolatkar, Anders G. Vahlne, Indresh K. Srivastava, Susan W. Barnett, and R. Holland Cheng. "Putative role of Tat–Env interaction in HIV infection." AIDS 27, no. 15 (September 2013): 2345–54. http://dx.doi.org/10.1097/01.aids.0000432453.60733.b2.

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Murakami, Tsutomu, Sherimay Ablan, Eric O. Freed, and Yuetsu Tanaka. "Regulation of Human Immunodeficiency Virus Type 1 Env-Mediated Membrane Fusion by Viral Protease Activity." Journal of Virology 78, no. 2 (January 15, 2004): 1026–31. http://dx.doi.org/10.1128/jvi.78.2.1026-1031.2004.

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ABSTRACT We and others have presented evidence for a direct interaction between the matrix (MA) domain of the human immunodeficiency virus type 1 (HIV-1) Gag protein and the cytoplasmic tail of the transmembrane envelope (Env) glycoprotein gp41. In addition, it has been postulated that the MA domain of Gag undergoes a conformational change following Gag processing, and the cytoplasmic tail of gp41 has been shown to modulate Env-mediated membrane fusion activity. Together, these results raise the possibility that the interaction between the gp41 cytoplasmic tail and MA is regulated by protease (PR)-mediated Gag processing, perhaps affecting Env function. To examine whether Gag processing affects Env-mediated fusion, we compared the ability of wild-type (WT) HIV-1 Env and a mutant lacking the gp41 cytoplasmic tail to induce fusion in the context of an active (PR+) or inactive (PR−) viral PR. We observed that PR− virions bearing WT Env displayed defects in cell-cell fusion. Impaired fusion did not appear to be due to differences in the levels of virion-associated Env, in CD4-dependent binding to target cells, or in the formation of the CD4-induced gp41 six-helix bundle. Interestingly, truncation of the gp41 cytoplasmic tail reversed the fusion defect. These results suggest that interactions between unprocessed Gag and the gp41 cytoplasmic tail suppress fusion.
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Ilinskaya, Anna, Gisela Heidecker, and David Derse. "Opposing Effects of a Tyrosine-Based Sorting Motif and a PDZ-Binding Motif Regulate Human T-Lymphotropic Virus Type 1 Envelope Trafficking." Journal of Virology 84, no. 14 (May 12, 2010): 6995–7004. http://dx.doi.org/10.1128/jvi.01853-09.

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ABSTRACT Human T-lymphotropic virus type 1 (HTLV-1) envelope (Env) glycoprotein mediates binding of the virus to its receptor on the surface of target cells and subsequent fusion of virus and cell membranes. To better understand the mechanisms that control HTLV-1 Env trafficking and activity, we have examined two protein-protein interaction motifs in the cytoplasmic domain of Env. One is the sequence YSLI, which matches the consensus YXXΦ motifs that are known to interact with various adaptor protein complexes; the other is the sequence ESSL at the C terminus of Env, which matches the consensus PDZ-binding motif. We show here that mutations that destroy the YXXΦ motif increased Env expression on the cell surface and increased cell-cell fusion activity. In contrast, mutation of the PDZ-binding motif greatly diminished Env expression in cells, which could be restored to wild-type levels either by mutating the YXXΦ motif or by silencing AP2 and AP3, suggesting that interactions with PDZ proteins oppose an Env degradation pathway mediated by AP2 and AP3. Silencing of the PDZ protein hDlg1 did not affect Env expression, suggesting that hDlg1 is not a binding partner for Env. Substitution of the YSLI sequence in HTLV-1 Env with YXXΦ elements from other cell or virus membrane-spanning proteins resulted in alterations in Env accumulation in cells, incorporation into virions, and virion infectivity. Env variants containing YXXΦ motifs that are predicted to have high-affinity interaction with AP2 accumulated to lower steady-state levels. Interestingly, mutations that destroy the YXXΦ motif resulted in viruses that were not infectious by cell-free or cell-associated routes of infection. Unlike YXXΦ, the function of the PDZ-binding motif manifests itself only in the producer cells; AP2 silencing restored the incorporation of PDZ-deficient Env into virus-like particles (VLPs) and the infectivity of these VLPs to wild-type levels.
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West, John T., Sally K. Weldon, Stephanie Wyss, Xiaoxu Lin, Qin Yu, Markus Thali, and Eric Hunter. "Mutation of the Dominant Endocytosis Motif in Human Immunodeficiency Virus Type 1 gp41 Can Complement Matrix Mutations without Increasing Env Incorporation." Journal of Virology 76, no. 7 (April 1, 2002): 3338–49. http://dx.doi.org/10.1128/jvi.76.7.3338-3349.2002.

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ABSTRACT The human immunodeficiency virus type 1 transmembrane glycoprotein (TM) is efficiently endocytosed in a clathrin-dependent manner. Internalization is mediated by a tyrosine-containing motif within the cytoplasmic domain, and replacement of the cytoplasmic tyrosine by cysteine or phenylalanine increased expression of mutant glycoprotein on the surface of transfected cells by as much as 2.5-fold. Because interactions between the cytoplasmic domain of Env and the matrix protein (MA) have been suggested to mediate incorporation of Env in virus particles, we examined whether perturbation of endocytosis would alter incorporation. Proviruses were constructed to contain the wild-type or mutant Env in conjunction with point mutations in MA that had previously been shown to block Env incorporation. These constructs were used to evaluate the effect of glycoprotein endocytosis on incorporation into virus particles and to test the necessity for a specific interaction between Env and MA to mediate incorporation. Viruses produced from transfected 293T cells were used to infect various cell lines, including MAGI, H9, and CEMx174. Viruses encoding both a disrupted endocytosis motif signal and mutations within MA were significantly more infectious in MAGI cells than their counterparts encoding a mutant MA and wild-type Env. This complementation of infectivity for the MA incorporation mutant viruses was not due to increased glycoprotein incorporation into particles but instead reflected an enhanced fusogenicity of the mutated Env proteins. Our findings further support the concept that a specific interaction between the long cytoplasmic domain of TM and MA is required for efficient incorporation of Env into assembling virions. Alteration of the endocytosis signal of Env, and the resulting increase in cell surface glycoprotein, has no effect on incorporation despite demonstrable effects on fusion, virus entry, and infectivity.
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Dissertations / Theses on the topic "Interaction Env"

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Lu, Karyn Y. "Interaction Design Principles for Interactive Television." Thesis, Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/6962.

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Interactive television (iTV) is an umbrella term used to cover the convergence of television with digital media technologies such as computers, personal video recorders, game consoles, and mobile devices, enabling user interactivity. Increasingly, viewers are moving away from a "lean back" model of viewing to a more active "lean forward" one. When fully realized on a widespread scale in the United States, our current experience of watching television will be dramatically transformed. Because iTV is a new medium in its own right, however, standards for iTV programming and interaction in the United States remain undefined. This document identifies and articulates interaction design principles for interactive television programming in the United States. Chapter one presents a brief survey of the field as it stands in 2005. In chapters two and three, I categorize iTV by platforms and by persistent television genres, and present representative examples for each category. In chapter four, I provide an overview of existing design standards in related areas. Insights from chapters two, three, and four all serve to inform chapter five, in which I propose principles for iTV interaction design by looking closely at existing designs (both deployed and prototyped), conventions, and patterns of interaction. My analyses are rooted in visual culture and human-computer interaction design principles, and the design principles I offer are abstracted from the applications I analyze within this framework. Finally, in chapter six, I offer some conclusions and thoughts for future directions.
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Mawson, Mark. "Interactive fluid-structure interaction with many-core accelerators." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/interactive-fluidstructure-interaction-with-manycore-accelerators(a4fc2068-bac7-4511-960d-41d2560a0ea1).html.

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The use of accelerator technology, particularly Graphics Processing Units (GPUs), for scientific computing has increased greatly over the last decade. While this technology allows larger and more complicated problems to be solved faster than before it also presents another opportunity: the real-time and interactive solution of problems. This work aims to investigate the progress that GPU technology has made towards allowing fluid-structure interaction (FSI) problems to be solved in real-time, and to facilitate user interaction with such a solver. A mesoscopic scale fluid flow solver is implemented on third generation nVidia ‘Kepler’ GPUs in two and three dimensions, and its performance studied and compared with existing literature. Following careful optimisation the solvers are found to be at least as efficient as existing work, reaching peak efficiencies of 93% compared with theoretical values. These solvers are then coupled with a novel immersed boundary method, allowing boundaries defined at arbitrary coordinates to interact with the structured fluid domain through a set of singular forces. The limiting factor of the performance of this method is found to be the integration of forces and velocities over the fluid and boundaries; the arbitrary location of boundary markers makes the memory accesses during these integrations largely random, leading to poor utilisation of the available memory bandwidth. In sample cases, the efficiency of the method is found to be as low as 2.7%, although in most scenarios this inefficiency is masked by the fact that the time taken to evolve the fluid flow dominates the overall execution time of the solver. Finally, techniques to visualise the fluid flow in-situ are implemented, and used to allow user interaction with the solvers. Initially this is achieved via keyboard and mouse to control the fluid properties and create boundaries within the fluid, and later by using an image based depth sensor to import real world geometry into the fluid. The work concludes that, for 2D problems, real-time interactive FSI solvers can be implemented on a single laptop-based GPU. In 3D the memory (both size and bandwidth) of the GPU limits the solver to relatively simple cases. Recommendations for future work to allow larger and more complicated test cases to be solved in real-time are then made to complete the work.
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Pinheiro, Clemilton Lopes. "Integração de fatos formulativos e interacionais na construção do texto : um estudo a partir da topicalidade /." Assis : [s.n], 2003. http://hdl.handle.net/11449/102480.

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Possui anexo em volume separado
Orientador: Clélia Cândida Abreu Spinardi Jubran
Banca: José Gaston Hilgert
Banca: Ingedore Grunfeld Villaça Koch
Banca: Maria Helena de Moura Neves
Banca: Odilon Helou Fleury Curado
Resumo: Neste trabalho, investigo a integração de fatos formulativos e interacionais, na construção do texto, a partir da análise da sua organização tópica. A análise da organização tópica leva em consideração a identificação e delimitação de segmentos tópicos e dos procedimentos pelos quais esses segmentos se distribuem na linearidade do texto e se recobrem hierarquicamente. A maneira como os segmentos tópicos, nível intertópico, e os enunciados que compõem esses segmentos, nível intratópico, se vinculam lingüisticamente na materialidade do texto constitui a estratégia textual-interativa que denomino de articulação tópica. Tomo, então, a articulação tópica como uma estratégia de formulação textual que apresenta demandas pragmáticas, e detecto os mecanismos pelos quais ela se atualiza em diferentes usos da língua, analisando-os como fatos textuais-interativos. Os postulados da Pragmática, da Lingüística Textual de orientação mais recente e da perspectiva textual-interativa formam o tripé teórico que orienta o trabalho. Os dados foram coletados em um corpus constituído de textos selecionados entre gêneros textuais prototípicos de fala e de escrita e intermediários: carta pessoal, artigo de opinião, artigo científico, conversação espontânea, aula, palestra, entrevista falada e escrita e reportagem, de televisão e de revista. Os resultados mostraram que, como mecanismos de articulação tópica, são empregados marcadores discursivos, formas referenciais, formulações metadiscursivas, perguntas e paráfrases, que realizam, tanto no plano da constituição interna dos segmentos tópicos mínimos, intratópico, como no plano da articulação desses segmentos entre si, intertópico, movimentos que sinalizam a construção textual, relacionados a diversos aspectos do processo interacional.
Abstract: In this work, I investigate the integration of facts formulativos and interactive, in the operation of the text, starting from the analysis of its topical organization. The analysis of the topical organization takes in consideration the identification and delimitation of topical segments and of the procedures for the which those segments are distributed in the sequencing of the text and is recovered hierarchically. The way as the topical segments, level intertopical, and the statements that compose those segments, level intratopical, is linguistically linked in the text surface constitutes the textual-interactive strategy that denominate of topical articulation. I take, then, the topical articulation as a strategy of textual formulation that it presents pragmatic demands, and I detect the mechanisms for the which she is used in different instances of the language, analyzing them as textual-interactive facts. The postulates of the Pragmatic, of the Textual Linguistics of more recent orientation and of the textual-interactive perspective they form the theoretical tripod that guides the work. The data were collected within a corpus constituted of texts selected among spoken, written and intermediate prototypical textual genres: personal letter, opinion article, scientific article, spontaneous conversation, class, lecture, written and spoken interviews and of magazines and televisions report. The results showed that, as mechanisms of topical articulation, discursive markers, referential forms, formulations metadiscursivas, questions and paraphrases are used. This mechanisms accomplish, so much in the plan of the internal constitution of the minimum topical segments, intratopical, as in the plan of the articulation of those segments to each other, intertopical, movements that signal the textual construction, related to several aspects of the process interactive.
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Fabre, John B., and n/a. "Designing time at the user interface a study of temporal aspects of usability." Swinburne University of Technology, 2000. http://adt.lib.swin.edu.au./public/adt-VSWT20060712.121947.

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This thesis is concerned with temporal factors from the perspective of the interactive designer/interface designer and usability as a construct for guiding design activity. The research reported herein examines the many factors which emerge when considering the name of interaction at the user interface. Temporal Aspects of Usability (TAU) is presented as a multivariate construct. It is neither a property that exists 'in the head alone' not is it an aspect of the system but rather an emergent property arising from task based interactions. From a theoretical perspective, it is argued that the inclusion of temporal considerations to the task model more fully specifies 'Usability' as a design construct. A model of TAU is evolved and validated utilizing situated interviews with designers. This resulted in an Enhanced model of TAU. A method for developing temporally informed task models, KAT-LITTER (Leveraging Interactions Through Effective Responses), provides temporal design heuristics as the confluence of, KAT (Knowledge Analysis of Task) a task analysis method, and the enhanced TAU model. As a method, KAT-LITTER is device independent, data centered, domain specific and necessarily independent of existing implementations. A process evaluation of KAT-LITTER showed that it influenced the design process in two significant ways: firstly, designers using KAT-LITTER spent more time reasoning about temporal issues than designers using KAT alone, and secondly these same designers considered a broader spectrum of temporal issues. The development of TAU, its accompanying method, KAT-LITTER, complete with a notational system for analysis represent a significant step forward.
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Galloway, Dayna. "Establishing methodologies for the analysis and development of interactive documentary." Thesis, Abertay University, 2013. https://rke.abertay.ac.uk/en/studentTheses/9e5996a7-e9e9-4538-a4bb-c940cacc1f7a.

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This work explores the interactive documentary as a hybrid, emergent cultural form that has been shaped by the growth of digital interactive entertainment. Through investigation and analysis of the historical background of documentary, the research discusses the development of documentary film, examining the notions of truth, objectivity and authorship in factual media, and their relationship with existing understandings of interactivity. Critical parameters are then derived to objectify the process of deconstructing interactive and documentary media forms. An inclusive view is taken on the categorisation and classification of interactive documentary, informed by the fundamental constructs of both traditional documentary and interactive media. The constructs and structures of interaction and narrative are highlighted to facilitate the identification and examination of existing examples of factual interactive entertainment– from computer generated documentary games to navigable filmic forms. The thesis proposes a range of characterisation frameworks for the study of interactive documentary and these are applied towards case study analysis of sixteen interactive productions. The final work presented in this thesis proposes a theoretical framework for the analysis and development of immersive, interactive documentary experiences, encompassing the processes of content creation and consumption from the perspectives of both audience and director.
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Mohamed, Shamim P. "End-user specification of interactive displays." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186439.

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Presenting data graphically can often increase its understandability--well-designed graphics can be more effective than a tabular display of numbers. It is much easier to get an understanding of the relationships and groupings in data by looking at a pictorial representation than at raw numbers. Most visualization systems to date, however, have allowed users to only choose from a small number of pre-defined display methods. This does not allow the easy development of new and innovative display techniques. These systems also present a static display--users cannot interact with and explore the data. More innovative displays, and the systems that implement them, tend to be extremely specialised, and closely associated with an underlying application. We propose techniques and a system where the user can specify most kinds of displays. It provides facilities to integrate user-input devices into the display, so that users can interact and experiment with the data. This encourages an exploratory approach to data understanding. Most users of such systems have the sophistication to use advanced techniques, but conventional programming languages are too hard to learn just for occasional use. It is well known that direct manipulation is a powerful technique for novice users; systems that use it are much easier to learn and remember for occasional use. We provide a system that uses these techniques to provide a visualization tool. Extensions to the WYSIWYG (What You See Is What You Get) metaphor are provided to handle its shortcomings, the difficulty of specifying deferred actions and abstract objects. In the data graphics domain, the main drawbacks of WYSIWYG systems are the difficulty of allowing a variable number of data items, and specifying conditional structures. This system also encourages re-use and sharing of commonly used display idioms. Pre-existing displays can be easily incorporated into new displays, and also modified to suit the users' specific needs. This allows novices and unsophisticated users to modify and effectively use display techniques that advanced users have designed.
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Mandage, Rajendra 1984. "Understanding interactions between EBV and human genomic variation." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/586328.

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The EBV has been linked to multiple human disease phenotypes and has been associated with cancers and other infections. Recently single gene analysis and genome-wide analysis studies have been exploited to uncover the human genetic variants that are linked with EBV diseases. It also suggested the substantial role of individual host genetics and also provided a clue in understanding the interaction between virus and human. Furthermore, the outcome of the EBV infection is a complex phenomenon governs by the variation in the genetic architecture of the viral and human genomes and/or the interacting environmental factors. Therefore, this PhD work is mainly a large-scale effort towards the understanding of the human and EBV genetic architecture to uncover the role of genetic variation in EBV associated infections, disease susceptibility, immune recognition and invasion. Our results also provide a framework on the impact of human and EBV genetic variation and their unusual interactions that highlight the human genetic influence affecting viral load reflecting the clinical behavior of EBV in LCLs and the other side viral antigenic variation modulating immune response to sustain persistence infection. This EBV-human perturbation is essential to follow-up in the context of the susceptibility of individual populations to a specific EBV associated pathology.
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McKenzie, Graeme. "EHV-1 and its interactions with cellular membranes." Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604289.

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Equine herpes virus 1 (EHV-1) causes abortion and neurological disease in horses, largely through the infection of endothelial cells and consequent inflammation which leads to a disruption of the vascular supply to the pregnant uterus and spinal cord. Although many different cell types are susceptible to infection, it is the cell associated viraemia which disseminates virus to these sites of secondary replication. Therefore, in recent years a great deal of research has focused on understanding the binding and entry of EHV-1 to several mammalian cell types. Like other alphaherpes viruses, EHV-1 has been shown to utilise several binding receptors and uptake mechanisms to infect its many permissible cell types. In the current study the physical characteristics of EHV-1 were determined and the mechanism of viral binding and fusion into rabbit kidney 13 cells (RK13s) and resting and activated peripheral blood mononuclear cells (PBMC) was observed. EHV-1 was identified as being 266 nm in diameter and had a zeta potential of -33 mV. Heat inactivated (HI) EHV-1 was shown to co -localise with GM-1 suggesting that it may associate with lipid rafts. Following infection of PBMC collected from horses with homozygous major histocompatibility complex class 1 (MHC-1) serological haplotypes (A2, A3 and A9) withEHV-1 strain RacL11 expressing green fluorescent protein (GFP) in place of glycoprotein 2(.1gp2), no apparent difference in infection was observed. Various fluorescence ii based fusion and endocytosis experiments were carried out using HI EHV- l Ab4 to infect RK13s and equine PBMC to examine the mechanisms involved, but the techniques proved too insensitive. The data suggest that initially, EHV-l associates with rafts and that MHC- l haplotype has no effect on viral infection of PBMCs. It was concluded that heat inactivation may damage viral glycoproteins sufficiently to reduce viral fusion and that future experiments should use live, infectious virus. ii
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Popov, Igor. "End-user data-centric interactions over linked data." Thesis, University of Southampton, 2013. https://eprints.soton.ac.uk/361729/.

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The ability to build tools that support gathering and querying information from distributed sources on the Web rests on the availability of structured data. Linked Data, as a way for publishing and linking distributed structured data sources on the Web, provides an opportunity to create this kind of tools. Currently, however, the ability to complete such tasks over Linked Data sources is limited to users with advanced technical skills, resulting in an online information space largely inaccessible to non-technical end users. This thesis explores the challenges of designing user interfaces for end users, those without technical skills, to use Linked Data to solve information tasks that require combining information from multiple sources. The thesis explores the design space around interfaces that support access to Linked Data on demand, suggests potential use cases and stakeholders, and proposes several direct manipulation tools for end users with diverse needs and skills. User studies indicate that the tools built offer solutions to various challenges in accessing Linked Data that are identified in this thesis.
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Palmquist, Lena. "Exploring self-efficacy in end-user programming : a feminist approach." Licentiate thesis, Umeå universitet, Institutionen för datavetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-91504.

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Digital services and devices are today more spread than ever, forming a basis for new innovations, even among ordinary people. And yet, producers of such services and devices are mostly men with programming skills. Women's participation in development and design of digital products is thus not yet as influential as that of men. An approach to this situation is to offer web-based environments for end-user development where people with no programming experiences have the opportunity to develop their own smartphone applications. The SATIN project, a collaboration between universities and IT-companies, has taken such an approach, with a focus on supporting female end-users. This project has been serving as a case in this research with the purpose of exploring and understanding end-user programming related to self-efficacy and female strategies. Experiences from being a member of the SATIN project are accounted for as well as results from qualitative observation studies capturing subjects’ reactions to the system. In the first set of observations, 9 subjects tested a mock-up version of the so-called SATIN editor, where the actual app building takes place. Later on a second set of observations with 11 subjects focused on how to support computer self-efficacy and end-user programming strategies that women prefer to a higher degree than men. Observations indicate that the women where as positive to making use of the editor as the men. The test subjects also showed signs of motivation as well as creativity while exploring the system. An observation related to design aspects of the system was that the quality of the components that form the smartphone apps seems to be crucial if the system is expected to truly support strategies that women request. Supporting women's own perceptions of self-efficacy related to developing computer-based systems is challenging, still indications of acceptance and enthusiasm for the system were observed. From a design perspective, using strategies and self-efficacy sources as an evaluation framework in the development process shows potential for improved design, and not only when designing for female users, but for diverse groups of users, hopefully paving the way for a more diverse community of producers of computer-based products.
SATIN 2 project
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Books on the topic "Interaction Env"

1

Iachello, Giovanni. End-user privacy in human-computer interaction. Boston: Now Publishers, 2007.

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Ravden, Susannah J. Evaluating usability of human-computer interfaces: A practical method. Chichester: E. Horwood, 1989.

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I, Johnson G., ed. Evaluating usability of human-computer interfaces: A practical method. Chichester [England]: E. Horwood, 1989.

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Faulkner, Ann. Interaction efficace avec les malades. St. Hyacinthe, Qué: Edisem, 1993.

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The end of books--or books without end?: Reading interactive narratives. Ann Arbor: University of Michigan Press, 2000.

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The plural actor. Cambridge, UK: Polity, 2011.

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Burnett, Margaret. Bringing HCI research to bear upon end-user requirement specification. [Corvallis, OR: Oregon State University, Dept. of Computer Science, 2002.

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Public access systems: Bringing computer power to the people. Norwood, N.J: Ablex Pub. Corp., 1994.

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Science and providence: God's interaction with the world. Boston: New Science Library, 1989.

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Science and providence: God's interaction with the world. London: SPCK, 1989.

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Book chapters on the topic "Interaction Env"

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de Sá, Marco, and Luís Carriço. "Supporting End-User Development of Personalized Mobile Learning Tools." In Human-Computer Interaction. Interacting in Various Application Domains, 217–25. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-02583-9_25.

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Eraslan, Sukru, and Chris Bailey. "End-User Evaluations." In Human–Computer Interaction Series, 185–210. London: Springer London, 2019. http://dx.doi.org/10.1007/978-1-4471-7440-0_11.

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Jay, Caroline, Darren Lunn, and Eleni Michailidou. "End User Evaluations." In Human-Computer Interaction Series, 107–26. London: Springer London, 2008. http://dx.doi.org/10.1007/978-1-84800-050-6_8.

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Takács, Árpád, Imre J. Rudas, and Tamás Haidegger. "The Other End of Human–Robot Interaction." In Human–Robot Interaction, 137–70. Boca Raton, FL : CRC Press/Taylor & Francis Group, [2019]: Chapman and Hall/CRC, 2019. http://dx.doi.org/10.1201/9781315213781-10.

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Blackwell, Alan F. "Psychological Issues in End-User Programming." In Human-Computer Interaction Series, 9–30. Dordrecht: Springer Netherlands, 2006. http://dx.doi.org/10.1007/1-4020-5386-x_2.

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Klann, Markus, Fabio Paternò, and Volker Wulf. "Future Perspectives in End-User Development." In Human-Computer Interaction Series, 475–86. Dordrecht: Springer Netherlands, 2006. http://dx.doi.org/10.1007/1-4020-5386-x_21.

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Rode, Jochen, Mary Beth Rosson, and Manuel A. Pérez Qui˜nones. "End User Development of Web Applications." In Human-Computer Interaction Series, 161–82. Dordrecht: Springer Netherlands, 2006. http://dx.doi.org/10.1007/1-4020-5386-x_8.

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Efthimiou, Eleni, Stavroula-Evita Fotinea, Panos Kakoulidis, Theodore Goulas, Athansia-Lida Dimou, and Anna Vacalopoulou. "Sign Search and Sign Synthesis Made Easy to End User: The Paradigm of Building a SL Oriented Interface for Accessing and Managing Educational Content." In Universal Access in Human–Computer Interaction. Designing Novel Interactions, 14–26. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-58703-5_2.

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Zhang, Yuhao, Md Zakir Hossain, and Shafin Rahman. "DeepVANet: A Deep End-to-End Network for Multi-modal Emotion Recognition." In Human-Computer Interaction – INTERACT 2021, 227–37. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-85613-7_16.

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Girgensohn, Andreas. "Modifier: Improving an end-user modifiable system through user studies." In Human Computer Interaction, 141–52. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/3-540-57312-7_65.

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Conference papers on the topic "Interaction Env"

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Pandey, Vishnudatt, Gargi Tiwari, Vijaya Shri Mall, Rakesh Kumar Tiwari, and Rajendra Prasad Ojha. "Interaction between gp120 and ligand in HIV-1 env protein: Molecular dynamics simulations and binding free energy calculations." In ADVANCES IN BASIC SCIENCE (ICABS 2019). AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5122491.

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Wu, Xijia. "A Model of Nonlinear Fatigue-Creep (Dwell) Interactions." In ASME Turbo Expo 2008: Power for Land, Sea, and Air. ASMEDC, 2008. http://dx.doi.org/10.1115/gt2008-51527.

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A nonlinear creep/dwell-interaction model is derived based on nucleation and propagation of a surface fatigue crack and its coalescence with creep/dwell damages (cavities or wedge cracks) along its path inside the material, which results in the total damage accumulation rate as given by dadN=1+lc+lzλdadNf+dadNenv where (da/dN)f is the pure fatigue crack growth rate, (da/dN)env is the environment-assisted crack growth rate, lc/lz is the cavity/wedge crack size, and λ is the average spacing between the internal cavities or cracks. Since wedge cracks are usually present in the form of dislocation pile-ups at low temperatures and cavitation usually occurs at high temperatures, the model attempts to reconcile the creep/dwell-fatigue phenomena over a broad temperature range of engineering concern. In particular, the model has been used to explain dwell fatigue of titanium alloys and high temperature creep-fatigue interactions in Ni-base superalloys under TCCR, CCCR, THCR and CHCR test conditions (see Annex A for definition of the terminology).
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Yang, Dongming, Yuexian Zou, Can Zhang, Meng Cao, and Jie Chen. "RR-Net: Injecting Interactive Semantics in Human-Object Interaction Detection." In Thirtieth International Joint Conference on Artificial Intelligence {IJCAI-21}. California: International Joint Conferences on Artificial Intelligence Organization, 2021. http://dx.doi.org/10.24963/ijcai.2021/169.

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Human-Object Interaction (HOI) detection devotes to learn how humans interact with surrounding objects. Latest end-to-end HOI detectors are short of relation reasoning, which leads to inability to learn HOI-specific interactive semantics for predictions. In this paper, we therefore propose novel relation reasoning for HOI detection. We first present a progressive Relation-aware Frame, which brings a new structure and parameter sharing pattern for interaction inference. Upon the frame, an Interaction Intensifier Module and a Correlation Parsing Module are carefully designed, where: a) interactive semantics from humans can be exploited and passed to objects to intensify interactions, b) interactive correlations among humans, objects and interactions are integrated to promote predictions. Based on modules above, we construct an end-to-end trainable framework named Relation Reasoning Network (abbr. RR-Net). Extensive experiments show that our proposed RR-Net sets a new state-of-the-art on both V-COCO and HICO-DET benchmarks and improves the baseline about 5.5% and 9.8% relatively, validating that this first effort in exploring relation reasoning and integrating interactive semantics has brought obvious improvement for end-to-end HOI detection.
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Luis Ricardo Ruiz, Fernando De la Rosa R., and Jose Tiberio Hernandez. "Platform integrating interactive applications with gesture-based interaction." In 2012 XXXVIII Conferencia Latinoamericana En Informatica (CLEI). IEEE, 2012. http://dx.doi.org/10.1109/clei.2012.6427129.

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Yang, Dongming, and Yuexian Zou. "A Graph-based Interactive Reasoning for Human-Object Interaction Detection." In Twenty-Ninth International Joint Conference on Artificial Intelligence and Seventeenth Pacific Rim International Conference on Artificial Intelligence {IJCAI-PRICAI-20}. California: International Joint Conferences on Artificial Intelligence Organization, 2020. http://dx.doi.org/10.24963/ijcai.2020/155.

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Human-Object Interaction (HOI) detection devotes to learn how humans interact with surrounding objects via inferring triplets of < human, verb, object >. However, recent HOI detection methods mostly rely on additional annotations (e.g., human pose) and neglect powerful interactive reasoning beyond convolutions. In this paper, we present a novel graph-based interactive reasoning model called Interactive Graph (abbr. in-Graph) to infer HOIs, in which interactive semantics implied among visual targets are efficiently exploited. The proposed model consists of a project function that maps related targets from convolution space to a graph-based semantic space, a message passing process propagating semantics among all nodes and an update function transforming the reasoned nodes back to convolution space. Furthermore, we construct a new framework to assemble in-Graph models for detecting HOIs, namely in-GraphNet. Beyond inferring HOIs using instance features respectively, the framework dynamically parses pairwise interactive semantics among visual targets by integrating two-level in-Graphs, i.e., scene-wide and instance-wide in-Graphs. Our framework is end-to-end trainable and free from costly annotations like human pose. Extensive experiments show that our proposed framework outperforms existing HOI detection methods on both V-COCO and HICO-DET benchmarks and improves the baseline about 9.4% and 15% relatively, validating its efficacy in detecting HOIs.
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El Bani, Wail, and Mohamed Chetouani. "Touch Recognition with Attentive End-to-End Model." In ICMI '20: INTERNATIONAL CONFERENCE ON MULTIMODAL INTERACTION. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3382507.3418834.

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Singh, Ravendra, Indrani Chatterjee, and Smrati. "Reliable End-to-End APNs interaction framework." In 2014 International Conference on Computing for Sustainable Global Development (INDIACom). IEEE, 2014. http://dx.doi.org/10.1109/indiacom.2014.6828098.

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Taveira, Mauricio Cândido. "Las pruebas de usabilidad e interfaz audiovisual en la película interactiva Arthur 2.0." In III Congreso Internacional de Investigación en Artes Visuales :: ANIAV 2017 :: GLOCAL. Valencia: Universitat Politècnica València, 2017. http://dx.doi.org/10.4995/aniav.2017.5758.

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La investigación se ocupa de la película interactiva de diseño interactivo Arthur 2.0 y Pericles Silveira. Examina, a partir de las pruebas de usabilidad, 6 momentos de interacción entre el interactor y el diseño interactivo de la película. Estos momentos se llaman Momentos Interactores (MI) y para comprobar si la interfaz película lleva a cabo de manera eficiente las tareas para las que fue diseñado: para hacer el plano de la película, en estos tiempos, ser lo más neutral posible y que las decisiones y las decisiones de la película provienen de los deseos del interactor y no la interfaz. La recolección de datos enfoca el uso de una combinación de métodos y técnicas - es decir, la observación y cuestionarios en un entorno con el público objetivo: los jóvenes de 12 a 17 años y adultos de 18 a 27 años y también con los espectadores de 28 a 37 años; 38-47 años y 48-68 años. En un sistema de interacción, ¿quién tiene el control? ¿Es el interactor? ¿El diseñador? ¿O el sistema? ¿Qué es un buen diseño interactivo y lo que es un mal diseño de interacción? Son algunas de las consideraciones que el trabajo es a partir de ese estudio.http://dx.doi.org/10.4995/ANIAV.2017.5758
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Pham, Hai Xuan, Yuting Wang, and Vladimir Pavlovic. "End-to-end Learning for 3D Facial Animation from Speech." In ICMI '18: INTERNATIONAL CONFERENCE ON MULTIMODAL INTERACTION. New York, NY, USA: ACM, 2018. http://dx.doi.org/10.1145/3242969.3243017.

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Sertolli, Benjamin, Nicholas Cummins, Abdulkadir Sengur, and Bjoern W. Schuller. "Deep End-to-End Representation Learning for Food Type Recognition from Speech." In ICMI '18: INTERNATIONAL CONFERENCE ON MULTIMODAL INTERACTION. New York, NY, USA: ACM, 2018. http://dx.doi.org/10.1145/3242969.3243683.

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Reports on the topic "Interaction Env"

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Leitch, Paul, Thomas Tassinari, Carole Winterhalter, James Fairneny, and Jean Herbert. Interactive Textiles Front End Analysis. Phase 1. Fort Belvoir, VA: Defense Technical Information Center, November 1998. http://dx.doi.org/10.21236/ada361143.

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Ghanipoor Machiani, Sahar, Aryan Sohrabi, and Arash Jahangiri. Impact of Regular and Narrow AV-Exclusive Lanes on Manual Driver Behavior. Mineta Transportation Institute, October 2020. http://dx.doi.org/10.31979/mti.2020.1922.

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This study attempts to answer the question of how a narrow (9-ft) lane dedicated to Automated Vehicles (AVs) would affect the behavior of drivers in the adjacent lane to the right. To this end, a custom driving simulator environment was designed mimicking the Interstate 15 smart corridor in San Diego. A group of participants was assigned to drive next to the simulated 9-ft narrow lane while a control group was assigned to drive next to a regular 12-ft AV lane. Driver behavior was analyzed by measuring the mean lane position, mean speed, and mental effort (self-reported/subjective measure). In addition to AV lane width, the experimental design took into consideration AV headway, gender, and right lane traffic to investigate possible interaction effects. The results showed no significant differences in the speed and mental effort of drivers while indicating significant differences in lane positioning. Although the overall effect of AV lane width was not significant, there were some significant interaction effects between lane width and other factors (i.e., driver gender and presence of traffic on the next regular lane to the right). Across all the significant interactions, there was no case in which those factors stayed constant while AV lane width changed between the groups, indicating that the significant difference stemmed from the other factors rather than the lane width. However, the trend observed was that drivers driving next to the 12-ft lane had better lane centering compared to the 9ft lane. The analysis also showed that while in general female drivers tended to drive further away from the 9-ft lane and performed worse in terms of lane centering, they performed better than male drivers when right-lane traffic was present. This study contributes to understanding the behavioral impacts of infrastructure adaptation to AVs on non-AV drivers.
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Crook, L. R. Jr, S. Reich, and M. L. Godec. Natural gas storage and end user interaction: A progress report, September 30, 1994--March 31, 1995. Office of Scientific and Technical Information (OSTI), July 1995. http://dx.doi.org/10.2172/105858.

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Lerma Noriega, Claudia Alicia. Implementación del periodismo interactivo en los portales de la prensa mexicana. Revista Latina de Comunicación Social, 2009. http://dx.doi.org/10.4185/rlcs-64-2009-861-787-801.

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Astudillo Estévez, Pablo A. Análisis de conectividad vial en los países de la Región Andina. Inter-American Development Bank, March 2021. http://dx.doi.org/10.18235/0003334.

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Se generó una herramienta computacional, basada en análisis de big data y ciencia de redes, la cual permite el análisis de la conectividad vial de los países de la región andina (Venezuela, Colombia, Ecuador, Perú y Bolivia). Su objetivo final es facilitar la ubicación de áreas geográficas prioritarias en las cuales se pueda focalizar la inversión en infraestructura. Esta herramienta permite identificar de manera interactiva los patrones de movilidad entre ciudades, el potencial de transporte de las vías, la relevancia de las urbes para la conectividad vial nacional y los hubs geográficos y de desarrollo.
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Guirado Zamora, María Remedios. La interacción de los públicos en Facebook. El caso de los periódicos en Andalucía.- The interaction of public in Facebook. The study of newspapers in Andalucía. Revista Internacional de Relaciones Públicas, May 2012. http://dx.doi.org/10.5783/rirp-3-2012-02-27-44.

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Balaguer, J. La territorialidad virtual en la creación participativa: El mapa interactivo y sus paisajes como forma de comunicación. Sociedad Latina de Comunicación Social, February 2020. http://dx.doi.org/10.4185/cac166-1.

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Alaimo, Veronica, María Noel Chaves, and Nicolás Soler. El futuro del trabajo en América Latina y el Caribe: ¿Cómo garantizar los derechos de los trabajadores en la era digital? (versión interactiva). Inter-American Development Bank, December 2019. http://dx.doi.org/10.18235/0002087.

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Amaral, Nicole, Oliver Azuara Herrera, Stephanie González, Carlos Ospino, Carmen Pagés, Graciana Rucci, and Jesica Torres. El futuro del trabajo en América Latina y el Caribe: ¿Cuáles son las ocupaciones y las habilidades emergentes más demandadas en la región? (versión interactiva). Inter-American Development Bank, April 2019. http://dx.doi.org/10.18235/0001677.

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Bustelo, Monserrat, Agustina Suaya, and Mariana Viollaz. El futuro del trabajo en América Latina y el Caribe: ¿Cómo será el mercado laboral para las mujeres? (versión interactiva). Inter-American Development Bank, October 2019. http://dx.doi.org/10.18235/0001933.

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