Relevant bibliographies by topics / Interaction ligand/enzyme

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Interaction ligand/enzyme'

Author: Grafiati
Published: 10 September 2022

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Journal articles on the topic "Interaction ligand/enzyme"

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Kuznetsov, Aleksei, and Jaak Järv. "Ligand structure controlled allostery in cAMP-dependent protein kinase catalytic subunit." Open Life Sciences 4, no. 2 (2009): 131–41. http://dx.doi.org/10.2478/s11535-009-0012-6.

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AbstractProtein kinase A (cAMP dependent protein kinase catalytic subunit, EC 2.7.11.11) binds simultaneously ATP and a phosphorylatable peptide. These structurally dissimilar allosteric ligands influence the binding effectiveness of each other. The same situation is observed with substrate congeners, which reversibly inhibit the enzyme. In this review these allosteric effects are quantified using the interaction factor, which compares binding effectiveness of ligands with the free enzyme and the pre-loaded enzyme complex containing another ligand. This analysis revealed that the allosteric ef
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Merugu, Ramchander, Uttam Kumar Neerudu, Karunakar Dasa, and Kalpana V. Singh. "Molecular docking studies of deacetylbisacodyl with intestinal sucrase-maltase enzyme." International Journal of Advances in Scientific Research 2, no. 12 (2017): 191. http://dx.doi.org/10.7439/ijasr.v2i12.3821.

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Molecular docking of sucrase-isomaltase with ligand deacetylbisacodyl when subjected to docking analysis using docking server, predicted in-silico result with a free energy of -3.36 Kcal/mol which was agreed well with physiological range for protein-ligand interaction, making bisacodyl probable potent anti-isomaltase molecule. According to docking server Inhibition constant is 5.98Mm. which predicts that the ligand is going to inhibits enzyme and result in a clinically relevant drug interaction with a substrate for the enzyme. Hydrogen bond with bond length 3.45is formed between Pro 64 (A) of
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Mulyati, Budi, та Riong Seulina Panjaitan. "Studi Penambatan Molekul Flavonoid Pada Reseptor α-Glukosidase menggunakan PLANTS". JURNAL KIMIA MULAWARMAN 18, № 2 (2021): 68. http://dx.doi.org/10.30872/jkm.v18i2.1004.

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ABSTRACT 
 
 Plants that contain flavonoids are widely used in traditional medicine. Flavonoids can reduce blood glucose levels with their ability as anti-oxidants. The purpose of this study was to determine natural compounds from flavonoid derivatives that have good affinity and conformation and their interactions in inhibiting α-glucosidase (an enzyme that breaks down carbohydrates into glucose) and determine the sequence of ligands that interact more strongly with α protein / enzyme α-glucosidase. Molecular docking is a computational method that aims to imitate the interaction of
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BOUGIE, Isabelle, Amélie PARENT, and Martin BISAILLON. "Thermodynamics of ligand binding by the yeast mRNA-capping enzyme reveals different modes of binding." Biochemical Journal 384, no. 2 (2004): 411–20. http://dx.doi.org/10.1042/bj20041112.

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RNA-capping enzymes are involved in the synthesis of the cap structure found at the 5′-end of eukaryotic mRNAs. The present study reports a detailed study on the thermodynamic parameters involved in the interaction of an RNA-capping enzyme with its ligands. Analysis of the interaction of the Saccharomyces cerevisiae RNA-capping enzyme (Ceg1) with GTP, RNA and manganese ions revealed significant differences between the binding forces that drive the interaction of the enzyme with its RNA and GTP substrates. Our thermodynamic analyses indicate that the initial association of GTP with the Ceg1 pro
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HOWES, Barry D., Nigel C. VEITCH, Andrew T. SMITH, Christopher G. WHITE, and Giulietta SMULEVICH. "Haem-linked interactions in horseradish peroxidase revealed by spectroscopic analysis of the Phe-221→Met mutant." Biochemical Journal 353, no. 2 (2001): 181–91. http://dx.doi.org/10.1042/bj3530181.

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A gene encoding a Phe-221-to-Met substitution in the haem enzyme horseradish peroxidase has been constructed and expressed in Escherichia coli. In the wild-type enzyme the side chain of Phe-221 is tightly stacked against the imidazole ring of His-170, which provides the only axial ligand to the haem iron atom. The Phe-221 → Met enzyme is active, and forms characteristic complexes with typical peroxidase ligands (CO, cyanide, fluoride), and with benzhydroxamic acid. Significant differences between the mutant and wild-type enzymes can be detected spectroscopically. These include a change in the
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Tharuni, Boya, T. Sathish, G. Nadana Raja Vadivu, and K. Vasumathi. "IN SILICO ANALYSIS OF DELTA 6 DESATURASE - A KEY ENZYME FOR OMEGA €“3/6€“ FATTY ACID PRODUCTION." International Journal of Advanced Research 9, no. 02 (2021): 818–23. http://dx.doi.org/10.21474/ijar01/12519.

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Delta 6 desaturase is a key enzyme involved in the production of omega 3/6 fatty acids and it is the rate-limiting step. The study aims to characterize the delta 6 desaturase enzyme and to find the binding affinity of various ligand with the protein by docking. It is found that delta 6 desaturase enzyme sequence is very unique and has less similarity with the other desaturase protein. The structural analysis was performed by Ramachandran plot and SCOPe structure prediction. Modeller is used to determine the DOPE score of the selected enzyme. The lowest DOPE score protein is chosen to determine
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Veniere, Sylvie, Christophe Ampe, Joël Vandekerckhove, and Anja Lambrechts. "The Interaction of Proline-Rich Ligands with Profilin Probed with an Enzyme-Linked Immunosorbent Assay." Journal of Biomolecular Screening 14, no. 4 (2009): 350–59. http://dx.doi.org/10.1177/1087057109332594.

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To detect interactions of different proline-rich ligands with profilins, the authors developed a simple analytical antibody-based screening method. Profilin I or profilin IIa was coated in microplates, and ligand binding was monitored via antibody detection. Using purified components, the authors show that the assay is very sensitive as nanomolar concentrations of recombinant profilin ligands can be used. They further apply this technique to detect interaction of profilin with various proline-rich partners, either endogenously present or ectopically expressed as tagged fusions, using lysates.
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SYGUSCH, Jurgen, and Danielle BEAUDRY. "Subunit interaction in mammalian aldolases." Biochemical Journal 323, no. 3 (1997): 671–76. http://dx.doi.org/10.1042/bj3230671.

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Enzyme inactivation was utilized to study subunit interaction in the homotetrameric glycolytic enzyme, aldolase. Isoenzymes from rabbit liver and skeletal muscle were inactivated in the presence of Pi and d-glyceraldehyde-P to a maximum stoichiometry of one modification per aldolase subunit. Subunit modification increased net negative charge on each subunit surface and was used to resolve modified aldolase isoenzymes into various chromatographic species. A combination of anion-(Mono Q) and cation- (Mono S) exchange chromatography separated the modified aldolase homotetramers into three distinc
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Aziz, Fitri Kusvila, Cantika Nukitasari, Fauziyah Ardli Oktavianingrum, Lita Windy Aryati, and Broto Santoso. "Hasil In Silico Senyawa Z12501572, Z00321025, SCB5631028 dan SCB13970547 dibandingkan Turunan Zerumbon terhadap Human Liver Glycogen Phosphorylase (1l5Q) sebagai Antidiabetes." Jurnal Kimia VALENSI 2, no. 2 (2016): 120–24. http://dx.doi.org/10.15408/jkv.v2i2.4170.

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Abstrak Human Liver Glycogen Phosphorylase (HLGP), suatu katalis glikogen yang mengontrol pelepasan glukosa-1-fosfat glikogen dari hati. Enzim ini mempunyai peran sentral dalam luaran glukosa hati sehingga menjadi target obat antidiabetik. Kajian docking dilakukan pada komputer dengan prosesor Intel Pentium, RAM 1 GB dan Windows 7. Ligan yang digunakan adalah senyawa obat (Z12501572, Z00321025, SCB5631028 dan SCB13970547), dataset pembanding aktif glycogen phosphorylase outer dimer site (PYGL-out) dan decoysdari www.dekois.com dan turunan zerumbon. Protein dipisahkan dari ligan nativ dan semua
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Vadivelu, Annapoorna. "Molecular docking studies of 1,3,4 -thiadiazoles as myeloperoxidase inhibitors." Journal of Pharmaceutical and Biological Sciences 9, no. 1 (2021): 63–69. http://dx.doi.org/10.18231/j.jpbs.2021.008.

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Myeloperoxidase (MPO) is a heterodimeric, cationic and glycosylated haeme enzyme which gets released under increased oxidative stress producing neutrophil oxidant, hypochlorous acid having the capacity to modify various biomolecules by chlorination and/or oxidation of sulfhydryl groups in proteins causing their inactivation and promoting inflammatory tissue damage. Different levels of hypochlorus acid are used as a trait marker for prescribing the disorders e.g. atherosclerosis, rheumatoid arthritis, lung cancer, Immuno-reactivity. Mini library of 22500 2,5disubstituted 1,3,4 thiadiazoles were
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Dissertations / Theses on the topic "Interaction ligand/enzyme"

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Hermansson, Anders. "Calculating Ligand-Protein Binding Energies from Molecular Dynamics Simulations." Thesis, KTH, Skolan för kemivetenskap (CHE), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-170722.

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Indications that existing parameter sets of extended Linear Interaction Energy (LIE) models are transferable between lipases from Rhizomucor Miehei and Thermomyces Lanigunosus in complex with a small set of vinyl esters are demonstrated. By calculat- ing energy terms that represents the cost of forming cavities filled by the ligand and the complex we can add them to a LIE model with en established parameter set. The levels of precision attained will be comparable to those of an optimal fit. It is also demonstrated that the Molecular Mechanics/Poisson Boltzmann Surface Area (MM/PBSA) and Molecu
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Rodrigues, Fábio Henrique dos Santos 1986. "Derivados de quinazolinas na inibição da adenosina quinase." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248424.

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Orientador: Ljubica Tasic<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-19T12:26:39Z (GMT). No. of bitstreams: 1 Rodrigues_FabioHenriquedosSantos_M.pdf: 24628982 bytes, checksum: f6b1490bc6bf2bf5497e5cad40a40daa (MD5) Previous issue date: 2011<br>Resumo: A Adenosina Quinase (ADK) é uma enzima importante (EC 2.7.1.20), cuja ação pode estar relacionada a diversas doenças, tais como inflamações, derrame, infarto, entre outras. Desse modo, a inibição de sua atividade é de grande importância, e desperta interesse científ
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Anissimova, Marya. "Application du ligand pseudo-biospécifique (IDA-ME (II)) à l'étude de la relation structure/fonction des protéines natives et modifiées." Compiègne, 1999. http://www.theses.fr/1999COMP1228.

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L’étude de la structure des protéines présente un intérêt majeur en biochimie pour permettre de comprendre et d'interpréter leur fonctionnement. Dans ce travail, les relations structure/fonction d'enzymes natives et modifiées ont été étudiées par le biais de leurs interactions avec les ions métalliques immobilisés. Notre première exploitation des interactions métaux chélatés - protéines a été l'application de l'électrophorèse d'affinité sur gel avec les ions métalliques immobilisés (IMAGE) comme outil d'étude des changements dans la topographie des résidus histidine dans les ribonucléases micr
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Le, Thao Nhi. "Le frelon asiatique (Vespa velutina nigrithorax) : Stratégies d’études sur l’identification de nouvelles molécules actives pour la dermacosmétique." Thesis, Orléans, 2020. http://www.theses.fr/2020ORLE3143.

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La recherche de nouveaux composés pour prévenir ou atténuer le vieillissement de la peau est une priorité des recherches actuelles dans les cosmétiques. Dans ce contexte, le venin de frelon asiatique (Vespa velutina nigrithorax) a été étudié comme une source particulière de molécules potentiellement bioactives d’intérêt dermacosmétique. La première étude a tout d’abord porté sur la mise en œuvre d’un protocole fiable d’extraction et récupération du venin. Puis, la fraction peptidique et petites molécules a été sélectionnée afin d’évaluer, en comparaison avec le venin brut, la présence de moléc
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Zhou, Min. "Understanding non-covalent interactions : cooperativity in ligand binding and enzyme catalysis." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615013.

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Ferey, Justine. "Développement d'outils analytiques basés sur la spectrométrie de masse pour le suivi d'interactions enzyme-ligand dans le domaine de la santé." Thesis, Orléans, 2017. http://www.theses.fr/2017ORLE2051/document.

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Les enzymes et leur diversité d’actions sont appréciées dans des domaines d’applications variés allant del’agroalimentaire à la thérapeutique. Ainsi, une attention toute particulière est portée à leur étude afin d’améliorer uneaction (contre le vieillissement de la peau, antivirale, anticancéreuse…) ou un procédé de synthèse. Ce projet derecherche s’inscrit dans une démarche de développement d’outils analytiques basés sur la spectrométrie de masse,permettant le suivi rapide et sensible d’interactions enzyme-ligand.Dans une première étude, l’approche TLC couplée à une détection par UV a été éva
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Yagnik, Asutosh Trilochan. "Molecular modelling applications in rational drug design and the study of enzyme-ligand interactions." Thesis, University of Exeter, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245931.

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Prasannan, Charulata Bhaskaran. "Modulation of restriction enzyme PvuII activity by metal ion cofactors." Diss., St. Louis, Mo. : University of Missouri--St. Louis, 2009. http://etd.umsl.edu/r4461.

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Geitmann, Matthis. "Biosensor Studies of Ligand Interactions with Structurally Flexible Enzymes : Applications for Antiviral Drug Development." Doctoral thesis, Uppsala universitet, Institutionen för naturvetenskaplig biokemi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5797.

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The use of a surface plasmon biosensor fills a missing link in kinetic studies of enzymes, since it measures directly the interaction between biomolecules and allows determination of parameters that are determined only indirectly in activity assays. The present thesis deals with kinetic and dynamic aspects of ligand binding to two viral enzymes: the human cytomegalovirus (HCMV) protease and the human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT). The improved description of interactions presented herein will contribute to the discovery and development of antiviral drugs. The b
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Li, Quinn. "Elucidating enzyme catalytic power and protein-ligand dynamics of human glucokinase: the role of modern allostery." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6461.

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Glucokinase (GK) is an enzyme that catalyzes the ATP-dependent phosphorylation of glucose to form glucose-6-phosphate, and it is a tightly regulated checkpoint in glucose homeostasis. The monomeric enzyme possesses a highly exotic kinetic profile, with a sigmoidal dependence on glucose, which has been the source of vigorous investigation and debate in the last several decades. This unique regulatory behavior can be thought of as a remarkable glucose sensor, which may result in hyperglycemia when it is not active enough and hypoglycemia when it is too active. This interdisciplinary study, which
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Books on the topic "Interaction ligand/enzyme"

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Kim, Sung-Kun (Sean), Dong-Woo Lee, and Ki Duk Park, eds. Interactions Between Small Molecule Ligands and Target Enzymes. Frontiers Media SA, 2021. http://dx.doi.org/10.3389/978-2-88966-685-0.

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Lambert, David G. Mechanisms and determinants of anaesthetic drug action. Edited by Michel M. R. F. Struys. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0013.

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This chapter is broken into two main sections: a general description of the principles of ligand receptor interaction and a discussion of the main groups of ‘targets’; and explanation of some common pharmacological interactions in anaesthesia, critical care, and pain management. Agonists bind to and activate receptors while antagonists bind to receptors and block the effects of agonists. Antagonists can be competitive (most common) or non-competitive/irreversible. The main classes of drug target are enzymes, carriers, ion channels, and receptors with examples of anaesthetic relevance interacti
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(Editor), Jonathan B. Chaires, and Michael J. Waring (Editor), eds. Drug-Nucleic Acid Interactions (Methods in Enzymology, Volume 340) (Methods in Enzymology). Academic Press, 2001.

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Book chapters on the topic "Interaction ligand/enzyme"

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Hussain, Rohanah, Charlotte S. Hughes, and Giuliano Siligardi. "Enzyme–Ligand Interaction Monitored by Synchrotron Radiation Circular Dichroism." In Methods in Molecular Biology. Springer US, 2019. http://dx.doi.org/10.1007/978-1-0716-0163-1_6.

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Guillemer, Sabrina, Cécile Persillon, Jean-Michel Masson, and Gilles Ravot. "Cell-Free Protein-Based Enzyme Discovery and Protein–Ligand Interaction Study." In Methods in Molecular Biology. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-782-2_8.

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Hussain, Rohanah, Charlotte S. Hughes, and Giuliano Siligardi. "Correction To: Enzyme–Ligand Interaction Monitored by Synchrotron Radiation Circular Dichroism." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0163-1_19.

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Kopperschläger, G., J. Kirchberger, T. Kriegel, and M. Naumann. "Dye-Ligand Affinity Partitioning — A Powerful Method for Studying Enzyme-Dye Interaction." In Protein-Dye Interactions: Developments and Applications. Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-1107-9_17.

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Bonomo, R. P., G. Impellizzeri, D. Mendola, et al. "Functional Mimics of Cu, Zn- Superoxide Dismutase Enzymes." In Metal-Ligand Interactions. Springer Netherlands, 2003. http://dx.doi.org/10.1007/978-94-010-0191-5_3.

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Cooper, Alan. "Microcalorimetry of Protein-Ligand Interactions." In The Enzyme Catalysis Process. Springer US, 1989. http://dx.doi.org/10.1007/978-1-4757-1607-8_25.

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Bennett, S. Paul, and Stephen E. Halford. "Mechanism and Specificity of two Restriction Enzymes, CauI and CauII, that Recognize Asymmetrical DNA Sequences." In DNA—Ligand Interactions. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5383-6_17.

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Liang, Shuguang, Wei Xu, Kurumi Y. Horiuchi, Yuan Wang, and Haiching Ma. "Chemical Microarrays: A New Tool for Discovery Enzyme Inhibitors." In Ligand-Macromolecular Interactions in Drug Discovery. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-244-5_9.

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Compadre, C. M., R. I. Sanchez, C. Bhuvaneswaran, R. L. Compadre, D. Plunkett, and S. G. Novick. "Analysis of enzyme-ligand interactions in organic solvents: A QSAR approach." In Trends in QSAR and Molecular Modelling 92. Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1472-1_15.

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Tirona, Rommel G. "Impact of Nuclear Receptors CAR, PXR, FXR, and VDR, and Their Ligands On Enzymes and Transporters." In Enzyme- and Transporter-Based Drug-Drug Interactions. Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-0840-7_4.

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Conference papers on the topic "Interaction ligand/enzyme"

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Dzichenka, Yaraslau, Michail Shapira, Sergei Usanov, et al. "NOVEL LIGANDS OF HUMAN CYP7 ENZYMES – POSSIBLE MODULATORS OF CHOLESTEROL BLOOD LEVEL: COMPUTER SIMULATION STUDIES." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.435d.

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Our in vitro studies showed that a couple of perspective steroidal derivatives showed previously biomedical potential via enzyme inhibition, receptor binding or antiproliferative effect against the cancer cells of reproductive tissues are able to bind to human CYP7 enzymes – key enzymes taking part in hydroxylation of cholesterol, 25-, 27-hydroxycholesterol and a number of steroidal hormones. In silico screening of binding affinity of the modified steroids toward CYP7 enzymes showed that interaction energy for the new ligands is comparable with consequent values, calculated for the ‘essential’
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Steiner, J., та D. Strickland. "INTERACTION OF PLASMIN WITH ALPHA-2 MACROGLOBULIN (α2 M): EFFECT OF ANTIFIBRINOLYTIC AGENTS". У XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644382.

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Harpel (Harpel, P.C. (1981) J. Clin. Invest 68, 46-55) reported that levels of α2M-plasmin complexes are elevated in patients receiving urokinase. He found that the distribution of plasmin between the two inhibitors, α2M and α2-plasmin inhibitor (α2PI) is dependent upon whether plasmin is added directly to plasma, or whether plasminogen in plasma is activated to plasmin by urokinase. In order to investigate possible mechanisms regulating the distribution of plasmin between these two inhibitors, a study was initiated to examine the effects of antifibrinolytic agents on the reaction of plasmin w
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Riethorst, W., M. W. P. M. te Booy, T. Beugeling, A. Bantjes, J. Over, and W. G. van Aken. "THE ISOLATION OF COAGULATION FACTOR VIII FROM HUMAN BLOOD PLASMA BY AFFINITY CHROMATOGRAPHY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644059.

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The need for high quality concentrates of coagulation factor VIII (FVIII:C) for treatment of haemophilia A is increasing. As the purity of FVIII:C obtained with existing large scale methods is poor and yields are low, another method for the isolation of FVIII is being developed primarily to avoid losses incurred during cryoprecipitation.Affinity gels were prepared by derivatizing Sepharose CL 4B with different positively charged ligand-spacer combinations. The adsorption of FVIII as well as the von Willebrand factor (VWF) from human blood plasma onto these gels was measured by a one-stage assa
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Timmons, Sheila, and Jack Hawiger. "REGULATION OF PLATELET RECEPTORS FOR FIBRINOGEN AND VON WILLEBRAND FACTOR BY PROTEIN KINASE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644674.

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Positive and negative regulation of platelet receptors for adhesive proteins, fibrinogen (F) and von Willebrand Factor (vWF) determines whether binding of these ligands will or will not take place. We have shown previously that ADP stimulates and cyclic AMP inhibits binding of F and vWF to human platelets. Now we show that positive regulation of F and vWF binding to platelets via the glycoprotein 11b/1111a complex is dependent on platelet Protein Kinase C, a calcium- and phospholipid-dependent enzyme. A potent activator of Protein Kinase C, phorbol-12-myristoyl-13-acetate (PMA) induced saturab
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