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Dissertations / Theses on the topic 'Interactive toxicity'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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1

Lyle, Zoe Jean. "The interactive toxicity of benzo(a)pyrene and ultraviolet radiation : an in vitro investigation." Thesis, University of Plymouth, 2008. http://hdl.handle.net/10026.1/2203.

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The work presented here adopted an in vitro approach with cell types from different species (fish: Epithelioma Papillosum Cyprini (EPCA1), Rainbow Trout Gonad (RTG-2); mammals: Chinese Hamster Ovary (CHO-K01), primary human fibroblast cells (84BR)) to elucidate the potential genotoxic effects of the interaction of the polycyclic aromatic hydrocarbon (PAH), benzo(a)pyrene (B(a)P) (0.0, 0.1, 1.0 and 3.2 µg mlˉ¹) with ultraviolet radiation (UVA/UVB) (typically 25, 50, 100, 200, 500, 1000, 2000, 4000, 6000, 8000 J mˉ²). Initially the experimental techniques and conditions were optimised and valida

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2

Betancourt-Lozano, Miguel. "Interactive toxicity of a triazole-derivative fungicide and an organophosphate pesticide in the marine shrimp Litopenaeus vannamei (Boone, 1931)." Thesis, University of Stirling, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365004.

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3

Vevers, William F. "Deoxynivalenol : toxicological profile and potential for reducing cereal grain contamination using bacterial additives in fermented animal feed." Thesis, University of Plymouth, 2015. http://hdl.handle.net/10026.1/4305.

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Deoxynivalenol (DON) contamination of grain destined for animal feeds is a major toxicological risk to monogastrics and is suspected of restricting productivity in ruminants. Whereas bacterial additives have been developed that can detoxify DON in the rumen and lower intestine, there are currently no commercial inoculants able to perform this task in crimped grain (CG) silage, a regionally important method of moist grain preservation based on homo- and heterofermentative lactic acid bacteria or chemical additives. Determining whether this ensiling process alongside the action of detoxifying ba

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4

Howarth, Julie Anne. "Aspects of the interaction between cadmium and the acute inflammatory response." Thesis, University of Surrey, 1988. http://epubs.surrey.ac.uk/847535/.

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The main aims of this thesis were to establish whether an acute inflammatory response is provoked in rats by the subcutaneous administration of cadmium, and to evaluate the possible role that such a response might play in the alterations in metal homeostasis and the development of anaemia which accompanies the use of this model of cadmium intoxication. An intense local reaction to the subcutaneous administration of cadmium was found. Many of the systemic changes, most notably in haematological parameters and in levels of iron, copper and plasma proteins, mimicked those seen in the acute inflam

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5

Perdrizet, Isabelle. "Toxicité du cisplatine." Paris 5, 1988. http://www.theses.fr/1988PA05P113.

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6

Santos, Bárbara Rosa da Fonseca. "Toxicity interaction of cooper and salinity on Perez frog life stages." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/7519.

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Mestrado em Ecologia, Biodiversidade e Gestão de Ecossistemas<br>Populations of amphibians are declining worldwide. Among the major causes for such decline are chemical contamination and climate changes (e.g. increase in temperature, salinization of coastal freshwater ecosystems). Actually, the group of amphibians may be very sensitive to these stressors as they possess a thin and permeable skin with no physical protection that allows cutaneous respiration but also the diffusion of chemical agents present in the environment. Furthermore, their biphasic life cycle exposes amphibains both to aqu

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7

Waterman, Kellie Lynne. "Interaction of Gold Nanoparticles with a Supported Lipid Bilayer Using Quartz Crystal Microblance with Dissipation." Digital WPI, 2013. https://digitalcommons.wpi.edu/etd-theses/291.

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Nanoparticle toxicity has become a major topic of interest due to the inevitable exposure of these nanomaterials to both humans and the environment. Nanotechnology is a rapidly growing industry with diverse material resources and an extensive market for commercialization and introduction of nanomaterials into consumer products. The problem with this flourishing technology is that it has far outgrown research based on the safety and toxicity of the nanomaterials, which in bulk are generally nontoxic. The need for research in determining the toxic effects on cells and the implications it may hav

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8

Tashjian, Diran Hovsep. "Selenium toxicokinetics, chronic toxicity, and interaction with salinity stress in white sturgeon /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2005. http://uclibs.org/PID/11984.

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9

Hsieh, Gin-Chang. "The Immunological and Neurochemical Toxicity of Benzene and its Interaction with Toluene in Mice." DigitalCommons@USU, 1988. https://digitalcommons.usu.edu/etd/4645.

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Benzene and toluene are known groundwater contaminants . Male CD-I mice were continuously exposed to 0, 31, 166, and 790 mg/ L benzene and 0, 17, 80, and 405 mg/L toluene, respectively, in drinking water for four weeks. Benzene caused a reduction of leukocytes, lymphocytes and erythrocytes, and resulted in a macrocytic anemia. Lymphocyte response to both B- and T-cell mitogens, mixed lymphocyte response to alloantigens, and the ability of cytotoxic lymphocytes to lyse tumor cells were enhanced at the lowest dose of benzene and depressed in the higher dosage animals. Benzene at doses of 166 and

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10

Md, Amin Roswati. "Copepods in Skeletonema-dominated food webs : Toxicity and nutritional quality as factors controlling copepod-diatom interactions." Doctoral thesis, Umeå universitet, Institutionen för ekologi, miljö och geovetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-49411.

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My thesis focuses on copepod-diatom interactions, specifically on the effects of food quality and toxicity on copepod feeding, reproductive success and behavior but as a frame, also includes a quantitative evaluation of copepod carbon requirements compared to other trophic plankton groups. My aim was to evaluate the function of copepods in diatom-dominated spring blooms. I thereby used a series of mesocosm and laboratory experiments. For a realistic extrapolation of the results to natural environments I used different strains of a diatom species, Skeletonema marinoi, which is a common spring b

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11

Johansson, Niclas. "Neonatal Exposure to Highly Brominated Diphenyl Ethers and Perfluorinated Compounds : Developmental Dependent Toxicity and Interaction." Doctoral thesis, Uppsala universitet, Ekotoxikologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-99255.

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This thesis investigated the developmental neurotoxic effects of neonatal exposure to highly brominated diphenyl ethers (PBDEs) and perfluorinated compounds (PFCs), alone or in combinations, during a critical period of the brains’ rapid growth and development, in mice. The compounds investigated were the decaBDE (PBDE 209), nonaBDE (PBDE 206), octaBDE (PBDE 203), heptaBDE (PBDE 183), and three PFCs, PFOS, PFOA, and PFDA. PBDEs and PFCs have been identified as emerging classes of persistent environmental compounds, present in wildlife as well as humans, and present at higher levels in infants/c

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12

Schilling, Judith [Verfasser]. "The Mutant HTT mRNA-Protein Interactome : Implications in RNA Toxicity in Huntington’s Disease / Judith Schilling." Bonn : Universitäts- und Landesbibliothek Bonn, 2017. http://d-nb.info/1171900392/34.

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13

Swann, Jonathan Richard. "Influence of gene-environment interaction on the gut microflora-mammalian contribution to metabolism and toxicity." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/8595.

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Gut microbial composition and activity exert a strong influence on the metabolic phenotype of the host, and variation in the metabolic phenotype is a major factor underlying inter-individual variation in drug responses. In this thesis, the role of gut microflora on the mammalian metabolic system was explored with specific focus on the influence on xenobiotic metabolism and toxicity. Systems biology approaches were utilised to examine microfloral-mammalian interactions and mechanisms of drug toxicity. Multi-omic techniques, namely transcriptomics and metabonomics, were employed to characterise

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14

Legrand, Philippe. "Amphotéricine B et amphotéricine B vectorisée : autoassociation, toxicité et interaction avec les macrophages." Paris 11, 1994. http://www.theses.fr/1994PA114820.

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15

Harley, Rachel. "Ion transport physiology and its interaction with trace element accumulation and toxicity in inanga (Galaxias maculatus)." Thesis, University of Canterbury. School of Biological Sciences, 2015. http://hdl.handle.net/10092/10738.

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Inanga (Galaxias maculatus) are a culturally and economically important fish species in New Zealand and abroad. However, very little is known about their ability to deal with trace element contamination. As a scaleless fish with the ability to survive in relatively extreme environments, they may not fit toxicity models (such as the biotic ligand model; BLM) based on other fish species. The aim of this study was to determine how this fish responds to elevated trace elements in both the laboratory and field in order to determine the applicability of these toxicity models. In order to determine

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16

Crevecoeur, Sophie. "Toxicologie de l'érythromycine." Paris 5, 1991. http://www.theses.fr/1991PA05P025.

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17

Frisk, Peter. "Expressions of mercury-selenium interaction in vitro." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-4913-1/.

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18

TenBrook, Patti Lyn. "Clomazone : toxicity, biotransformation, resistance and interaction with P450 inhibitors in rice (Oryza sativa) and watergrasses (Echinochloa spp.) /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2005. http://uclibs.org/PID/11984.

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19

Anjum, Farida. "Relative toxicity of insecticides to crucifer pests and their natural enemies : interaction of insecticide and insect behaviours." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/24773.

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Pesticides remain a necessary component of many agricultural systems and used judiciously they can play an important role in Integrated Pest Management (IPM) programmes. The aim of the present study was to investigate factors influencing the differential toxicity of insecticides against a cosmopolitan insect pest of crucifer crops, the diamondback moth, Plutella xylostella, and its respective hymenopteran parasitoid, Cotesia vestalis. Such knowledge can help in the effective use of insecticides with biological control agents in IPM. Three insecticides regarded as being compatible with some nat

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20

Hessler, Christopher Mark. "The Influence of Capsular Extracellular Polymeric Substances on the Toxicological Interaction Between Titanium Dioxide Nanoparticles and Planktonic Bacteria." University of Toledo / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1321645743.

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Ta, Ha Phuong. "Etude de la relation structure - toxicité des protéines amyloïdes en interaction avec des membranes modèles." Thesis, Bordeaux 1, 2011. http://www.theses.fr/2011BOR14361/document.

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Ce mémoire rapporte les études de protéines amyloïdes en interaction avec des membranes modèle afin d’établir une relation structure toxicité. Nous avons choisi différents modèles membranaires (monocouches, bicouches) de composition lipidique et charges différentes et utilisé différentes méthodes physico-chimiques afin de caractériser les interactions des protéines amyloïdes avec les membranes.Nous avons montré l’importance de la contribution électrostatique dans les interactions de la protéine amyloïde HET-s (218-289) et ses mutants avec les membranes modèles.L’ellipsométrie a démontré que le

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22

Le, Thanh Huong. "Toxicity of the cocktail of contaminants deoxynivalenol & cadmium to mammals with in vitro models." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30034.

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Le Cd est un métal lourd toxique très répandu. L'homme peut être exposé à ce contaminant environnemental par la fumée, la nourriture et l'eau. Le déoxynivalénol (DON) est l'une des mycotoxines les plus répandues dans les céréales. Si de nombreuses études ont étudié la toxicité du DON et du Cd individuellement, leur toxicité combinée est très peu connue. Cependant, les consommateurs peuvent être exposés à un mélange DON et Cd. Dans la présente étude, nous nous sommes concentrés sur les effets du DON et du Cd, seuls ou en combinaison, en utilisant une approche in vitro. Différentes lignées cellu

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23

Jonsson, Karl. "Are nAChRs and NMDA receptors involved in low dose ethanol-nicotine toxicity in SH-SY5Y cells?" Thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-193048.

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Consumption of alcohol and tobacco is common all around the world and these drugs are frequently consumed concomitantly. It has been estimated that 70-80 % of alcoholics are smokers and non-alcoholic drinkers are more often smokers than teetotallers. Alcohol and tobacco may affect the risk of developing neurological diseases and might influence this risk differently when combined compared to when only one of these compounds is consumed. Some in vitro-research have shown that non-toxic concentrations of ethanol and nicotine, in combination, can exert toxicity, and might do so in a synergistic w

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HUBERT, NOELLA. "Interaction fer et hepatocytes en culture : regulation des proteines du metabolisme du fer et toxicite cellulaire." Rennes 1, 1992. http://www.theses.fr/1992REN10144.

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De nombreuses inconnues subsistent dans le cadre de l'hemochromatose genetique (hg) ou une surcharge hepatocytaire en fer est observee. En effet, le gene responsable de cette maladie n'est toujours pas caracterise, les modifications de l'expression des proteines du metabolisme du fer lors de la surcharge ne sont pas clairement definies et enfin, les mecanismes impliques dans le developpement du carcinome hepatocellulaire restent a preciser. Afin d'apporter des elements de reponse a certaines de ces inconnues, nous avons developpe des modeles cellulaires de surcharge en fer faisant appel a des

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25

Taylor, Cameron S. "Characterisation of engineered nanoparticles and their interaction with natural biological and non-biological material." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:03810528-de65-4094-907c-8c0d4e0386c8.

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Form, mobility, toxicity and the eventual fate of engineered nanomaterials in environmental ecosystems are currently not well defined and are needed to improve risk assessment and legislation. The present study subjected uncoated zinc oxide (ZnO) nanoparticles (30nm and 200nm) and coated silver (Ag) nanoparticles (Paraffin: 3-8nm and citrate/PVP: 50nm) to different ionic strength media and different types of algal/bacterial extracellular-polymeric species (EPS) at long (6 months) and short (2 weeks) timescales. Changes in particle size distribution and stability were examined using a multi-met

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Yang, Zhongbao [Verfasser]. "The interaction between aluminium toxicity and drought stress in common bean (Phaseolus vulgaris L.) : physiological and molecular aspects / Zhongbao Yang." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover (TIB), 2011. http://d-nb.info/1015447910/34.

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27

Potdevin, Sophie. "Interaction des derives du platine avec les systemes de transport de la cellule tubulaire proximale renale." Paris 5, 1998. http://www.theses.fr/1998PA05N136.

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Le, Quang Dieu. "Métabolisme de la cyclosporine A et propriétés toxicopharmacologiques de ses métabolites." Paris 5, 1998. http://www.theses.fr/1998PA05P250.

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29

Bounab, Yacine. "CRMP1 protein complexes modulate polyQ-mediated Htt aggregation and toxicity in neurons." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16185.

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Chorea Huntington (HD) ist eine neurodegenerative Erkrankung, die durch Ablagerungen von N-terminal Polyglutamin-reichen Huntingtin (Htt) -Fragmenten in den betroffenen Neuronen charakterisiert ist. Das mutierte Htt (mHtt) Protein wird ubiquitär exprimiert. Das zellspezifische Absterben von „medium-sized spiny neurons“ (MSN) wird jedoch im Striatum von HD Patienten verursacht (Albin, 1995). Es wird angenommen, dass Striatum-spezifische Proteine, die mit Htt interagieren, eine wichtige Rolle in der Pathogenese von HD spielen (Ross, 1995). Protein-Protein-Interaktionsstudien haben gezeigt, dass

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Ferrec, Romain, and Petrus Oskam. "Building Relationships : Assessing the quality of the relationship between leaders and followers as an indication of authenticity vs. toxicity." Thesis, Linnéuniversitetet, Institutionen för organisation och entreprenörskap (OE), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-34708.

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Relationships are so entrenched in the social interaction between individuals that most people do not pay attention to them until they experience trouble in their relationship. Humans create new relationships and end old ones all the time in conscious and unconscious processes. This thesis will give a theoretical and practical overview to reveal the process of social interaction which shapes relationships between a leader and a follower. We focus on the necessary components as well as on the process in which the relationship is built. We approach the process of social interaction from both the

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Russ, Jenny. "Systematic interaction mapping reveals novel modifiers of neurodegenerative disease processes." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16631.

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Neurodegenerative Erkrankungen (NDs) wie Alzheimer (AD), Parkinson (PD), und amyotrophe lateral Sklerose (ALS) sind Hirnerkrankungen, die durch unlösliche Proteinaggregate in Neuronen oder im Extrazellularraum charakterisiert sind. In dieser Arbeit habe ich für verschiede bekannte und vorhergesagte neurodegenerative Krankheitsproteine (NDPs) Proteininteraktionsnetzwerke erstellt, um mögliche gemeinsame Krankheitsmechanismen genauer zu studieren. Mit Hilfe eines automatisierten Hefe-Zwei-Hybrid-Systems (Y2H) konnte ich 18.663 Protein-Protein-Interaktionen (PPIs) für 449 wildtyp und 22 mutierte

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Renzi, Maria Teresa. "Effects of pesticides on honey bees (Apis mellifera L.) : study of a specific route of exposure and evaluation of biochemical-physiological changes in the assessment of the pesticides toxicity." Phd thesis, Université d'Avignon, 2013. http://tel.archives-ouvertes.fr/tel-01002986.

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In this study, some important aspects of the relationship between honey bees (Apis mellifera L.) and pesticides have been investigated. In the first part of the research, the effects of the exposure of honey bees to neonicotinoids and fipronil contaminated dusts were analyzed. In fact, considerable amounts of these pesticides, employed for maize seed dressing treatments, may be dispersed during the sowing operations, thus representing a way of intoxication for honey bees. In particular, a specific way of exposure to this pesticides formulation, the indirect contact, was taken into account. To

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33

Fresneau, Brice. "Analyses pronostiques en oncologie pédiatrique : Identification de facteurs de susceptibilité tumorale ou individuelle à l’efficacité et/ou à la toxicité des traitements anticancéreux utilisés chez l’enfant Investigating the Heterogeneity of Alkylating Agents' Efficacy and Toxicity Between Sexes: A Systematic Review and Meta-Analysis of Randomized Trials Comparing Cyclophosphamide and Ifosfamide (MAIAGE Study) Is Alpha-Fetoprotein Decline a Prognostic Factor of Childhood Non-Seminomatous Germ Cell Tumours? Results of the French TGM95 Study New Insight into Severe Ototoxicity after Childhood Cancer. Is there an Impact of Melphalan and Busulfan? A French Childhood Cancer Survivor Study A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated with High-Dose Methotrexate: Data from the OS2006/Sarcoma-09 Trial." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASS034.

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Les progrès thérapeutiques en oncologie pédiatrique ont permis une amélioration des taux de survie qui dépassent aujourd’hui 80%. De façon à augmenter les taux de guérison et diminuer les complications et séquelles des traitements, des efforts collaboratifs internationaux ont permis le développement de protocoles thérapeutiques stratifiés sur les facteurs pronostiques majeurs incluant des facteurs biologiques tumoraux issus des analyses moléculaires et notamment génomiques. Cependant, si les traitements utilisés prennent de plus en plus en compte la biologie tumorale, leur adaptation aux facte

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Oudin, Philippe. "Interactions entre polychlorobiphényles et micro-organismes : modification expérimentale de la paroi de deux souches de levure Rhodotorula glutinis et Saccharomyces cerevisiae en vue de l'optimisation du phénomène de bioaccumulation." Nancy 1, 1998. http://www.theses.fr/1998NAN10361.

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Clift, Martin James David. "Quantum dots : an investigation into how differing surface characteristics affect their interaction with macrophages in vitro." Thesis, Edinburgh Napier University, 2009. http://researchrepository.napier.ac.uk/Output/2557.

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Quantum dots (QDs) are potentially advantageous tools for both diagnostics and therapeutics due to their light emitting characteristics. The impact of QDs on biological systems however, is not fully understood. The aim of this project therefore, was to investigate the interaction of a series of different surface modifies QDs with macrophages and their subsequent toxicity. CdTe/CdSe (core), ZnS (shell) QDs with either an organic, COOH or NH2 polyethylene glycol (PEG) surface coatings were used. Fluorescent COOH polystyrene beads (PBs) at (Ø) 20nm and 200nm were also studied. J774.A1 murine ‘mac

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CHAHINE, RAMEZ. "Recherches toxicologiques et pharmacologiques sur les effets de la metabolisation de la nicotine." Toulouse 3, 1989. http://www.theses.fr/1989TOU30008.

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Deon, Magnus Dall'Igna. "Crescimento e nutrição mineral da soja submetida a excesso de P, S, K, Ca e Mg em solução nutritiva." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/11/11140/tde-19072007-094401/.

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Um sistema de cultivo eficiente depende do correto manejo da nutrição das plantas. Desordens nutricionais podem ser induzidas por manejo da fertilização inadequada e excessiva, dentre elas toxidez e deficiência induzida de um nutriente por outro. Com o objetivo de avaliar o comportamento da soja cultivar CD-208 ao excesso de cinco macronutrientes em solução nutritiva, foi realizado um experimento em casa de vegetação. Os tratamentos constituíram-se de um controle baseado na solução nutritiva de Hoagland e Arnon (1950) e soluções nutritivas iguais a essa, com a adição de 1,5; 3,0; 4,5 e 6,0 mmo

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Rima, Wael. "Apport de la microscopie electronique dans la compréhension des mécanismes d’interactions entre nanoparticules et cellules biologiques." Thesis, Lyon, INSA, 2012. http://www.theses.fr/2012ISAL0131/document.

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Parmi les nanoparticules aptes à accompagner la radiothérapie en clinique, les nanoparticules à base d’oxyde de gadolinium paraissent pertinentes, de part leur multimodalité en imagerie et leur effet radiosensibilisant prouvé in vitro et in vivo. Cet effet de radiosensibilisation est exceptionnel notamment sur des cellules cancéreuses radiorésistantes de la lignée SQ20B (carcinome squameux tête et cou) et uniquement pour des doses modérées de nanoparticules (aux alentours de 0.6 mM en Gd). Les clichés de microscopie électronique ont montré que ce maximum de radiosensibilisation est dû à une in

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Torres, Arias Marbel. "Signalisation de l'immunité innée et Apicomplexes : Rôle de la protéine adaptatrice MyD88 et de l'inflammasome dans le contrôle de l'infection à Toxoplasma gondii ou à Cryptosporidium parvum." Thesis, Tours, 2013. http://www.theses.fr/2013TOUR3807.

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Les Apicomplexes constituent une vaste famille de parasites protozoaires responsables de nombreuses maladies chez l’Homme et chez les animaux. C’est le cas de Toxoplasma gondii, agent de la toxoplasmose et de Cryptosporidium parvum, responsable de la cryptosporidiose. Ces pathogènes représentent un réel problème de santé publique et vétérinaire. A l’heure actuelle, les seuls moyens de lutte contre ces parasites demeurent la chimiothérapie car il n’existe aucune stratégie prophylactique efficace. L’identification de cibles vaccinales repose sur le décryptage des mécanismes de défense mis en jeu

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Rima, Wael. "Apport de la microscopie electronique dans la compréhension des mécanismes d'interactions entre nanoparticules et cellules biologiques." Phd thesis, INSA de Lyon, 2012. http://tel.archives-ouvertes.fr/tel-00876351.

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Parmi les nanoparticules aptes à accompagner la radiothérapie en clinique, les nanoparticules à base d'oxyde de gadolinium paraissent pertinentes, de part leur multimodalité en imagerie et leur effet radiosensibilisant prouvé in vitro et in vivo. Cet effet de radiosensibilisation est exceptionnel notamment sur des cellules cancéreuses radiorésistantes de la lignée SQ20B (carcinome squameux tête et cou) et uniquement pour des doses modérées de nanoparticules (aux alentours de 0.6 mM en Gd). Les clichés de microscopie électronique ont montré que ce maximum de radiosensibilisation est dû à une in

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Al-Zebari, Nawar. "Production and characterisation of self-crosslinked chitosan-carrageenan polyelectrolyte complexes." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/267918.

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Macromolecular biomaterials often require covalent crosslinking to achieve adequate stability and mechanical strength for their given application. However, the use of auxiliary chemicals may be associated with long-term toxicity in the body. Oppositely-charged polyelectrolytes (PEs) have the advantage that they can self-crosslink electrostatically and those derived from marine organisms are an inexpensive alternative to glycosaminoglycans present in the extracellular matrix of human tissues. A range of different combinations of PEs and preparation conditions have been reported in the literatur

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Willemin, Marie-Émilie. "Modélisation de la toxicocinétique des isomères cis et trans de la perméthrine et de ses métabolites chez le rat et de leur métabolisme sur hépatocytes humains." Thesis, Compiègne, 2014. http://www.theses.fr/2014COMP2149/document.

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Les pyréthrinoïdes sont des insecticides auxquels la population est quotidiennement exposée. Le composé parent est suspecté d’induire des perturbations neuronales et hormonales chez l’homme. Au sein de cette famille, la perméthrine (mélange d’isomère cis et trans) est le composé le plus utilisé dans le traitement des intérieurs de maison. Dans ce travail de thèse, nous proposons de développer un modèle PBPK pour la perméthrine et certains de ses métabolites urinaires, utilisés comme biomarqueurs d’exposition, et d’évaluer les interactions métaboliques des deux isomères. Trois étapes ont été su

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Almasri, Hanine. "Toxicologie des mélanges de pesticides chez des abeilles exposées à un agent pathogène : action combinée de l'agent pathogène Nosema ceranae, de l'insecticide imidaclopride, du fongicide difénoconazole et de l'herbicide glyphosate Mixtures of an insecticide, a fungicide and a herbicide induce high toxicities and systemic physiological disturbances in winter Apis mellifera honey bees Toxicity of the pesticides imidacloprid, difenoconazole and glyphosate alone and in binary and ternary mixtures to winter honey bees: effects on survival and antioxidative defenses Toxicological status changes the susceptibility of the honey bee Apis mellifera to a single fungicidal spray application Physiological effects of the interaction between Nosema ceranae and sequential and overlapping exposure to glyphosate and difenoconazole in the honey bee Apis mellifera." Thesis, Avignon, 2020. http://www.theses.fr/2020AVIG0722.

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Les données scientifiques actuelles suggèrent un déclin de la diversité et de l’abondance des insectes, y compris les abeilles domestiques Apis mellifera. Ces dernières sont confrontées à de fortes pertes de colonies dans plusieurs régions du monde telles que l’ouest de l’Europe et les États-Unis. De nombreuses études suggèrent que l’origine du déclin des colonies d’abeilles est multicausale et identifient les pesticides et les agents pathogènes comme étant les principaux contributeurs à ce déclin. La co-exposition des abeilles à de multiples pesticides et l’infection par plusieurs pathogènes

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Ishac, Nicole. "Comment deux lignées cellulaires stromales mésenchymateuses humaines récapitulent in vitro le microenvironnement hématopoïétique ? : Intérêt en ingénierie." Thesis, Tours, 2015. http://www.theses.fr/2015TOUR4038/document.

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L’hématopoïèse se déroule dans un microenvironnement spécialisé appelé niche où les cellules souches hématopoïétiques (CSH) sont en contact étroit avec les cellules stromales mésenchymateuses. Cette interaction cellulaire associée à d’autres facteurs environnementaux, comme la présence des espèces réactives à l’oxygène, est cruciale pour la régulation des CSH normales, mais aussi leucémiques. Pour étudier ce microenvironnement, il est donc important de développer un modèle in vitro de niche humaine qui mime la physiologie in vivo. Nous avons choisi comme modèle deux lignées mésenchymateuses st

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LI, BO-LOU, and 李寶樓. "The interaction of manganese toxicity on inorganic nutrition of soybean plants." Thesis, 1989. http://ndltd.ncl.edu.tw/handle/23005301862998734497.

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Hall, Julie. "The interaction of chronic copper toxicity with nutrient limitation in two chlorophytes." 1987. http://hdl.handle.net/1993/30043.

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Rider, Cynthia V. "Development and application of an integrated addition and interaction model of mixture toxicity." 2005. http://www.lib.ncsu.edu/theses/available/etd-01022006-223335/unrestricted/etd.pdf.

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Fischer, Hans Christian. "Investigating the Interaction of Semiconductor Quantum Dots with in vivo and Cellular Environments to Determine Disposition and Risk." Thesis, 2010. http://hdl.handle.net/1807/26171.

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Nanomaterial toxicity is a major concern and could potentially hamper the progress of biomedical nanotechnology development. Dispelling these concerns requires that the consequences of nanomaterial exposure are evaluated, and the findings will determine whether developmental hurdles can be overcome. This thesis evaluates the both in vivo and in vitro impact of quantum dots (QD , zinc sulphide capped cadmium selenide semiconductor nanocrystals) a fluorescent nanoparticle label with potential as an optical in vivo imaging agent. This work reviews nanoparticle characterization techniques and t

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Fallon, Aurélie. "Pathological implications of the interaction between neurexins and alpha-synuclein in synucleinopathies." Thesis, 2020. http://hdl.handle.net/1866/25679.

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La maladie de Parkinson (PD) et la démence à corps de Lewy (DLB) sont les deuxième et troisième maladies neurodégénératives les plus communes et font partie d’une classe de maladies appelées synucléinopathies. Les synucléinopathies sont associées à une pathologie liée à l’α-synucléine (α-syn) laquelle se caractérise par une accumulation de cette protéine dans les neurones, formant ainsi les corps de Lewy. L’α-syn pathologique se retrouve aussi sous forme d’oligomères et de fibrilles, qui sont toxiques pour les neurones et leurs synapses. L’une des premières anomalies observables chez les patie

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Lee, Chia-Hua, and 李佳樺. "Assessing copper and lead interaction in contaminated sediments and their bioavailability and toxicity to larvae and embryos of medaka." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/sr9nfh.

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碩士<br>國立臺灣大學<br>農業化學研究所<br>107<br>In the river system, sediment is considered as a long-term source of contaminants for aquatic organisms due to its high accumulating capacity. Among all contaminants, heavy metals are of high concern because of their non-biodegradable nature. The bioavailability of these metals may be affected by sediment properties, transportation behavior between sediment-water system and physiology of aquatic organisms. To understand the chemical and biological interaction of sediment-bound contaminants to the aquatic life, this study used the whole-sediment exposure method

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