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Journal articles on the topic 'Intercalators'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 April 2022

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1

Sugawara, Yuuki, Takanori Tamaki, and Takeo Yamaguchi. "DNA molecular recognition of intercalators affects aggregation of a thermoresponsive polymer." Polym. Chem. 5, no. 16 (2014): 4612–16. http://dx.doi.org/10.1039/c4py00600c.

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2

Wink, Michael. "Potential of DNA Intercalating Alkaloids and Other Plant Secondary Metabolites against SARS-CoV-2 Causing COVID-19." Diversity 12, no. 5 (2020): 175. http://dx.doi.org/10.3390/d12050175.

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Many plants produce secondary metabolites (PSMs) with antiviral activities. Among the antiviral PSMs, lipophilic terpenoids in essential oils can disturb the lipid envelope of viruses. Phenols and polyphenols (flavonoids, rosmarinic acid and tannins) attack viral proteins present in the viral membrane or inside the virus particle. Both phenolics and essential oils are active against free viral particles but not—or to a lesser degree—after a virus has entered a host cell. Another group of PSMs is directed against DNA or RNA. These are DNA intercalators such as sanguinarine, berberine, emetine a

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3

Wilson, W. David. "ChemInform Abstract: DNA Intercalators." ChemInform 32, no. 5 (2001): no. http://dx.doi.org/10.1002/chin.200105275.

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4

TAKENAKA, Shigeori, Kunihiko DOHTSU, and Makoto TAKAGI. "Intercalator-induced gel-electrophoretic retardation of synthetic double-stranded oligonucleotides and comingration of intercalators." Analytical Sciences 6, no. 1 (1990): 139–41. http://dx.doi.org/10.2116/analsci.6.139.

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5

Takagi, Makoto. "Threading intercalation to double-stranded DNA and the application to DNA sensing. Electrochemical array technique." Pure and Applied Chemistry 73, no. 10 (2001): 1573–77. http://dx.doi.org/10.1351/pac200173101573.

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Electrochemical labeling of double-stranded (ds) DNA is achieved by redox-active DNA intercalators. Threading intercalators derived from naphthalenediimide appended with ferrocene reporter group in the side arms are particularly useful for this purpose. This allows a sensitive electrochemical detection of DNA hybridization on an array, providing a great potential for low-cost, high-throughput, and quick DNA screening technique in post-genome study.

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6

Gilad, Yocheved, and Hanoch Senderowitz. "Docking Studies on DNA Intercalators." Journal of Chemical Information and Modeling 54, no. 1 (2013): 96–107. http://dx.doi.org/10.1021/ci400352t.

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7

Liu, Hong-Ke, and Peter J. Sadler. "Metal Complexes as DNA Intercalators." Accounts of Chemical Research 44, no. 5 (2011): 349–59. http://dx.doi.org/10.1021/ar100140e.

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8

Zeglis, Brian M., Valerie C. Pierre, and Jacqueline K. Barton. "Metallo-intercalators and metallo-insertors." Chemical Communications, no. 44 (2007): 4565. http://dx.doi.org/10.1039/b710949k.

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9

Cory, Michael, TerriA Fairley, StevenC Zimmerman, and CarolR Lamberson. "Studies on polyfunctional DNA intercalators." Journal of Molecular Graphics 7, no. 3 (1989): 173–74. http://dx.doi.org/10.1016/0263-7855(89)80030-x.

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10

Terbrueggen, Robert H., Timothy W. Johann, and Jacqueline K. Barton. "Functionalized Rhodium Intercalators for DNA Recognition." Inorganic Chemistry 37, no. 26 (1998): 6874–83. http://dx.doi.org/10.1021/ic980837j.

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11

Shade, Chad M., Robert D. Kennedy, Jessica L. Rouge, et al. "Duplex-Selective Ruthenium-Based DNA Intercalators." Chemistry - A European Journal 21, no. 31 (2015): 10983–87. http://dx.doi.org/10.1002/chem.201502095.

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12

Bolhuis, Albert, Lorna Hand, Julia E. Marshall, Adair D. Richards, Alison Rodger, and Janice Aldrich-Wright. "Antimicrobial activity of ruthenium-based intercalators." European Journal of Pharmaceutical Sciences 42, no. 4 (2011): 313–17. http://dx.doi.org/10.1016/j.ejps.2010.12.004.

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13

Viglasky, Viktor, and Patrik Danko. "Intercalators: Contra cruciform extrusion in DNA." Analytical Biochemistry 360, no. 1 (2007): 7–13. http://dx.doi.org/10.1016/j.ab.2006.10.023.

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14

Satange, Roshan, Chien-Ying Chuang, Stephen Neidle, and Ming-Hon Hou. "Polymorphic G:G mismatches act as hotspots for inducing right-handed Z DNA by DNA intercalation." Nucleic Acids Research 47, no. 16 (2019): 8899–912. http://dx.doi.org/10.1093/nar/gkz653.

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Abstract DNA mismatches are highly polymorphic and dynamic in nature, albeit poorly characterized structurally. We utilized the antitumour antibiotic CoII(Chro)2 (Chro = chromomycin A3) to stabilize the palindromic duplex d(TTGGCGAA) DNA with two G:G mismatches, allowing X-ray crystallography-based monitoring of mismatch polymorphism. For the first time, the unusual geometry of several G:G mismatches including syn–syn, water mediated anti–syn and syn–syn-like conformations can be simultaneously observed in the crystal structure. The G:G mismatch sites of the d(TTGGCGAA) duplex can also act as

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15

Singh, Jasdeep, Ankit Srivastava, Pankaj Sharma, Prashant Pradhan, and Bishwajit Kundu. "DNA intercalators as amyloid assembly modulators: mechanistic insights." RSC Advances 7, no. 1 (2017): 493–506. http://dx.doi.org/10.1039/c6ra26313e.

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16

Totta, Xanthippi, Antonios G. Hatzidimitriou, Athanasios N. Papadopoulos, and George Psomas. "Nickel(ii)–naproxen mixed-ligand complexes: synthesis, structure, antioxidant activity and interaction with albumins and calf-thymus DNA." New Journal of Chemistry 41, no. 11 (2017): 4478–92. http://dx.doi.org/10.1039/c7nj00257b.

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17

Ghanem, Aml, Hamdy A. Emara, Shaden Muawia, Ahmed I. Abd El Maksoud, Ahmed A. Al-Karmalawy, and Mohamed F. Elshal. "Tanshinone IIA synergistically enhances the antitumor activity of doxorubicin by interfering with the PI3K/AKT/mTOR pathway and inhibition of topoisomerase II: in vitro and molecular docking studies." New Journal of Chemistry 44, no. 40 (2020): 17374–81. http://dx.doi.org/10.1039/d0nj04088f.

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18

al-Rashida, Mariya, and Sana Ahsen. "In search of a docking protocol to distinguish between DNA intercalators and groove binders: genetic algorithm vs. shape-complementarity based docking methods." RSC Advances 5, no. 88 (2015): 72394–404. http://dx.doi.org/10.1039/c5ra09929c.

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19

Kimball, Joseph D., Badri Maliwal, Sangram L. Raut, et al. "Enhanced DNA detection using a multiple pulse pumping scheme with time-gating (MPPTG)." Analyst 143, no. 12 (2018): 2819–27. http://dx.doi.org/10.1039/c8an00136g.

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20

Zhu, Haimei, Yuanbo Song, Yuji Wang та ін. "Design, synthesis and evaluation of a novel π–π stacking nano-intercalator as an anti-tumor agent". MedChemComm 7, № 2 (2016): 247–57. http://dx.doi.org/10.1039/c5md00507h.

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21

Derrat, Hanan S., Craig C. Robertson, Anthony J. H. M. Meijer, and Jim A. Thomas. "Turning intercalators into groove binders: synthesis, photophysics and DNA binding properties of tetracationic mononuclear ruthenium(ii)-based chromophore–quencher complexes." Dalton Transactions 47, no. 35 (2018): 12300–12307. http://dx.doi.org/10.1039/c8dt02633e.

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22

Liwinska, Wioletta, Michał Symonowicz, Iwona Stanislawska, Marek Lyp, Zbigniew Stojek, and Ewelina Zabost. "Environmentally sensitive nanohydrogels decorated with a three-strand oligonucleotide helix for controlled loading and prolonged release of intercalators." RSC Advances 6, no. 93 (2016): 91045–59. http://dx.doi.org/10.1039/c6ra16592c.

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23

Choi, Hoi Kil, Yuna Oh, Hana Jung, et al. "Influences of carboxyl functionalization of intercalators on exfoliation of graphite oxide: a molecular dynamics simulation." Physical Chemistry Chemical Physics 20, no. 45 (2018): 28616–22. http://dx.doi.org/10.1039/c8cp05436c.

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24

Leung, Euphemia, Lisa I. Pilkington, Mohinder M. Naiya, et al. "The cytotoxic potential of cationic triangulenes against tumour cells." MedChemComm 10, no. 11 (2019): 1881–91. http://dx.doi.org/10.1039/c9md00305c.

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25

Sun, Hang, Mohammad Fawad Ansari, Narsaiah Battini, Rammohan R. Yadav Bheemanaboina, and Cheng-He Zhou. "Novel potential artificial MRSA DNA intercalators: synthesis and biological evaluation of berberine-derived thiazolidinediones." Organic Chemistry Frontiers 6, no. 3 (2019): 319–34. http://dx.doi.org/10.1039/c8qo01180j.

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26

Mati|, Josipa, Lidija-Marija Tumir, Marijana Radi| Stojkovi|, and Ivo Piantanida. "Advances in Peptide-based DNA/RNA-Intercalators." Current Protein & Peptide Science 17, no. 2 (2016): 127–34. http://dx.doi.org/10.2174/138920371702160209124439.

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27

Ferguson, Lynnette R., and William A. Denny. "Genotoxicity of non-covalent interactions: DNA intercalators." Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 623, no. 1-2 (2007): 14–23. http://dx.doi.org/10.1016/j.mrfmmm.2007.03.014.

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28

Pages, Benjamin J., K. Benjamin Garbutcheon-Singh, and Janice R. Aldrich-Wright. "Platinum Intercalators of DNA as Anticancer Agents." European Journal of Inorganic Chemistry 2017, no. 12 (2017): 1613–24. http://dx.doi.org/10.1002/ejic.201601204.

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29

Suseela, Y. V., Shubhajit Das, Swapan K. Pati, and T. Govindaraju. "Imidazolyl-Naphthalenediimide-Based Threading Intercalators of DNA." ChemBioChem 17, no. 22 (2016): 2162–71. http://dx.doi.org/10.1002/cbic.201600478.

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30

Netz, Paulo Augusto. "Benzothiadiazoles as DNA intercalators: Docking and simulation." International Journal of Quantum Chemistry 112, no. 20 (2012): 3296–302. http://dx.doi.org/10.1002/qua.24174.

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31

Waring, Michael J., and Christian Bailly. "DNA recognition by intercalators and hybrid molecules." Journal of Molecular Recognition 7, no. 2 (1994): 109–22. http://dx.doi.org/10.1002/jmr.300070208.

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32

Pedersen, E. B., A. M. A. Osman, D. Globisch, et al. "Triplex glue by synthesizing conjugated flexible intercalators." Nucleic Acids Symposium Series 52, no. 1 (2008): 37–38. http://dx.doi.org/10.1093/nass/nrn019.

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33

Csuk, René, Alexander Barthel, Thorsten Brezesinski, and Christian Raschke. "Synthesis of pathogen inactivating nucleic acid intercalators." European Journal of Medicinal Chemistry 39, no. 11 (2004): 975–88. http://dx.doi.org/10.1016/j.ejmech.2004.07.011.

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34

Abufarag, Ahmed, and Jan Reedijk. "Ruthenium complexes tethered to organic DNA intercalators." Journal of Inorganic Biochemistry 59, no. 2-3 (1995): 137. http://dx.doi.org/10.1016/0162-0134(95)97245-l.

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35

Tao, Zhi-Fu, Xuhong Qian, and Jun Tang. "Synthesis of furonaphthalimides as novel DNA intercalators." Dyes and Pigments 30, no. 4 (1996): 247–52. http://dx.doi.org/10.1016/0143-7208(95)00082-8.

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36

Zhang, Ling, Kannekanti Vijaya Kumar, Syed Rasheed, Shao-Lin Zhang, Rong-Xia Geng, and Cheng-He Zhou. "Correction: Design, synthesis, and antibacterial evaluation of novel azolylthioether quinolones as MRSA DNA intercalators." MedChemComm 6, no. 7 (2015): 1405–6. http://dx.doi.org/10.1039/c5md90029h.

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37

Ghosh, Subhajit, Tapas Das, Shishu K. Suman, Chandan Kumar, Haladhar D. Sarma, and Ashutosh Dash. "Targeted Tumor Therapy with Radiolabeled DNA Intercalator: A Possibility? Preclinical Investigations with 177Lu-Acridine." BioMed Research International 2020 (July 25, 2020): 1–13. http://dx.doi.org/10.1155/2020/9514357.

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Objective. A DNA intercalating agent reversibly stacks between the adjacent base pairs of DNA and thus is expected to exhibit preferential localization in the tumorous lesions as tumors are associated with enhanced DNA replication. Therefore, radiolabeled DNA intercalators are supposed to have potential to be used in targeted tumor therapy. Working in this direction, an attempt was made to radiolabel 9-aminoacridine, a DNA intercalator, with 177Lu, one of the most useful therapeutic radionuclides, and study the potential of 177Lu-acridine in targeted tumor therapy. Experiments. 9-Aminoacridine

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38

Li, Jiahe, Hao Yan, Zhiyuan Wang, et al. "Copper chloride complexes with substituted 4′-phenyl-terpyridine ligands: synthesis, characterization, antiproliferative activities and DNA interactions." Dalton Transactions 50, no. 23 (2021): 8243–57. http://dx.doi.org/10.1039/d0dt03989f.

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Eleven copper chloride complexes with substituted 4′-phenyl-terpyridine ligands: high antiproliferative activities against five human carcinoma cell lines, strong affinity for binding with DNA as intercalators and multiple molecular docking results.

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39

Deo, Krishant, Benjamin Pages, Dale Ang, Christopher Gordon, and Janice Aldrich-Wright. "Transition Metal Intercalators as Anticancer Agents—Recent Advances." International Journal of Molecular Sciences 17, no. 11 (2016): 1818. http://dx.doi.org/10.3390/ijms17111818.

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40

Fisher, Dianne M., Ronald R. Fenton, and Janice R. Aldrich-Wright. "Platinum(II) intercalators as potential anti-cancer agents." Journal of Inorganic Biochemistry 96, no. 1 (2003): 131. http://dx.doi.org/10.1016/s0162-0134(03)80613-x.

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41

Gianolio, D. "Tethered naphthalene diimide intercalators enhance DNA triplex stability." Bioorganic & Medicinal Chemistry 9, no. 9 (2001): 2329–34. http://dx.doi.org/10.1016/s0968-0896(01)00135-3.

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42

Takenaka, Shigeori, and Makoto Takagi. "Threading Intercalators as a New DNA Structural Probe." Bulletin of the Chemical Society of Japan 72, no. 3 (1999): 327–37. http://dx.doi.org/10.1246/bcsj.72.327.

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43

Csuk, René, Christian Raschke, Gunnar Göthe, and Stefan Reißmann. "Synthesis of Monomeric Acridine Derived Nucleic Acid Intercalators." Zeitschrift für Naturforschung B 60, no. 1 (2005): 83–88. http://dx.doi.org/10.1515/znb-2005-0113.

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A series of antiviral compounds consisting of an intercalating acridine derived part, a spacer region and a reactive EDTA-derived conjugate was synthesized in an easy sequence. In the presence of ascorbate a reduction of the phage-titer of MS2 phages by several logarithmic decades was achieved.

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44

Csuk, René, Thorsten Brezesinski, Gunnar Göthe, Christian Raschke, and Stefan Reißmann. "Synthesis of Dimeric Acridine Derived Nucleic Acid Intercalators." Zeitschrift für Naturforschung B 60, no. 1 (2005): 89–98. http://dx.doi.org/10.1515/znb-2005-0114.

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A series of antiviral compounds consisting of an intercalating acridine derived part, a spacer region and a reactive EDTA-derived conjugate was synthesized in an easy sequence. Suitably monoprotected 1,ω-alkyldiamines gave upon reaction with 6,9-dichloro-2-methoxyacridine (1) followed by deprotection and reaction with EDTA dianhydride the target molecules. In the presence of ascorbate a reduction of the phage-titer of the MS2 phages by > 8 logarithmic decades was achieved.

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45

Greschner, Andrea A., Katherine E. Bujold, and Hanadi F. Sleiman. "Intercalators as Molecular Chaperones in DNA Self-Assembly." Journal of the American Chemical Society 135, no. 30 (2013): 11283–88. http://dx.doi.org/10.1021/ja404402b.

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46

Castaño-Álvarez, Mario, M. Teresa Fernández-Abedul, and Agustín Costa-García. "Electroactive intercalators for DNA analysis on microchip electrophoresis." ELECTROPHORESIS 28, no. 24 (2007): 4679–89. http://dx.doi.org/10.1002/elps.200700160.

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47

Gill, Martin R., Hanan Derrat, Carl G. W. Smythe, Giuseppe Battaglia, and Jim A. Thomas. "Ruthenium(II) Metallo-intercalators: DNA Imaging and Cytotoxicity." ChemBioChem 12, no. 6 (2011): 877–80. http://dx.doi.org/10.1002/cbic.201000782.

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48

Shobha Devi, C., B. Thulasiram, Rajeshwar Rao Aerva, and Penumaka Nagababu. "Recent Advances in Copper Intercalators as Anticancer Agents." Journal of Fluorescence 28, no. 5 (2018): 1195–205. http://dx.doi.org/10.1007/s10895-018-2283-7.

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49

Navarro, Maribel, Efrén José Cisneros-Fajardo, Aníbal Sierralta, et al. "Design of copper DNA intercalators with leishmanicidal activity." JBIC Journal of Biological Inorganic Chemistry 8, no. 4 (2003): 401–8. http://dx.doi.org/10.1007/s00775-002-0427-2.

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50

Hebenbrock, Marian, and Jens Müller. "1H-[1,2,4]Triazolo[4,3-a]pyridin-4-ium and 3H-[1,2,4]triazolo[4,3-a]quinolin-10-ium derivatives as new intercalating agents for DNA." Zeitschrift für Naturforschung B 73, no. 11 (2018): 885–93. http://dx.doi.org/10.1515/znb-2018-0089.

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AbstractTwo new cationic DNA intercalators, 3-phenyl-1-(6-phenylpyridin-2-yl)-1H-[1,2,4]triazolo[4,3-a]pyridin-4-ium (1a)+ and 1-phenyl-3-(6-phenylpyridin-2-yl)-3H-[1,2,4]triazolo[4,3-a]quinolin-10-ium (1b)+, were synthesized from 2-chloropyridine and 2-chloroquinoline, respectively, in a four-step procedure. Generation of the hydrazine, followed by condensation with an aldehyde to give a hydrazone and subsequent Buchwald-Hartwig amination gave a mixture of E- and Z-configured N,N-functionalized hydrazones. Finally, oxidative cyclisation gave rise to the formation of the cationic DNA intercala

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