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1

Ramsden, J. J. "The bio–nano interface." Nanotechnology Perceptions 5, no. 2 (2009): 151–65. http://dx.doi.org/10.4024/n11ra09a.ntp.05.02.

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2

Leszczynski, Jerzy. "Nano meets bio at the interface." Nature Nanotechnology 5, no. 9 (2010): 633–34. http://dx.doi.org/10.1038/nnano.2010.182.

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3

Prinz Setter, Ofer, and Ester Segal. "Halloysite nanotubes – the nano-bio interface." Nanoscale 12, no. 46 (2020): 23444–60. http://dx.doi.org/10.1039/d0nr06820a.

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4

Al-Mufti, A. Wesam, U. Hashim, Md Mijanur Rahman, and Tijjani Adam. "Nano–bio interface: the characterization of functional bio interface on silicon nanowire." Microsystem Technologies 21, no. 8 (2014): 1643–49. http://dx.doi.org/10.1007/s00542-014-2241-5.

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5

Torimitsu, Keiichi. "Nano-Bio Interface - Neural & Molecular Functions." Advances in Science and Technology 53 (October 2006): 91–96. http://dx.doi.org/10.4028/www.scientific.net/ast.53.91.

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This paper briefly introduces the nano-bio related-research being carried out in our research group. The work is based on a fusion of neuroscience and bio-molecular science with nanotechnology. This interdisciplinary research is extremely promising for creating a new technology and developing a new knowledge. Nano-bio research could be a key to understanding the signal processing mechanism that lies behind memory and the learning system in our brain. Developing a novel biocompatible device that runs with biological functions is one of our research goals.
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6

Wu, Rongrong, Mingdong Dong, and Lei Liu. "Nano–Bio Interface of Molybdenum Disulfide for Biological Applications." Coatings 13, no. 6 (2023): 1122. http://dx.doi.org/10.3390/coatings13061122.

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The unique nano–bio interfacial phenomena play a crucial role in the biosafety and bioapplications of nanomaterials. As a representative two-dimensional (2D) nanomaterial, molybdenum disulfide (MoS2) has shown great potential in biological applications due to its low toxicity and fascinating physicochemical properties. This review aims to highlight the nano–bio interface of MoS2 nanomaterials with the major biomolecules and the implications of their biosafety and novel bioapplications. First, the nano–bio interactions of MoS2 with amino acids, peptides, proteins, lipid membranes, and nucleic acids, as well as the associated applications in protein detection, DNA sequencing, antimicrobial activities, and wound-healing are introduced. Furthermore, to facilitate broader biomedical applications, we extensively evaluated the toxicity of MoS2 and discussed the strategies for functionalization through interactions among MoS2 and the variety of macromolecules to enhance the biocompatibility. Overall, understanding the nano–bio interface interaction of two-dimensional nanomaterials is significant for understanding their biocompatibility and biosafety, and further provide guidance for better biological applications in the future.
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7

Mohapatra, Shyam S. "EDITORIAL: NANOBIO COLLABORATIVE EXPLORES NANO-BIO INTERFACE." Technology & Innovation 13, no. 1 (2011): 1–3. http://dx.doi.org/10.3727/194982411x13003853540117.

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8

Rouse, Ian, David Power, Erik G. Brandt, et al. "First principles characterisation of bio–nano interface." Physical Chemistry Chemical Physics 23, no. 24 (2021): 13473–82. http://dx.doi.org/10.1039/d1cp01116b.

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We present a multiscale computational approach for the first-principles study of bio-nano interactions. Using titanium dioxide as a case study, we evaluate the affinity of titania nanoparticles to water and biomolecules through atomistic and coarse-grained techniques.
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9

Wang, Jing, Waseem Akthar Quershi, Yiye Li, Jianxun Xu, and Guangjun Nie. "Analytical methods for nano-bio interface interactions." Science China Chemistry 59, no. 11 (2016): 1467–78. http://dx.doi.org/10.1007/s11426-016-0340-1.

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10

Wang, Yan-Wen, Huan Tang, Di Wu, et al. "Enhanced bactericidal toxicity of silver nanoparticles by the antibiotic gentamicin." Environmental Science: Nano 3, no. 4 (2016): 788–98. http://dx.doi.org/10.1039/c6en00031b.

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11

Liang, Jieying, and Kang Liang. "Nano-bio-interface engineering of metal-organic frameworks." Nano Today 40 (October 2021): 101256. http://dx.doi.org/10.1016/j.nantod.2021.101256.

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12

Hennig, Andreas, Sheshanath Bhosale, Naomi Sakai, and Stefan Matile. "CD Methods Development at the Bio-Nano Interface." CHIMIA International Journal for Chemistry 62, no. 6 (2008): 493–96. http://dx.doi.org/10.2533/chimia.2008.493.

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13

Shang, Li, and G. Ulrich Nienhaus. "Small fluorescent nanoparticles at the nano–bio interface." Materials Today 16, no. 3 (2013): 58–66. http://dx.doi.org/10.1016/j.mattod.2013.03.005.

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14

Nel, Andre E., Lutz Mädler, Darrell Velegol, et al. "Understanding biophysicochemical interactions at the nano–bio interface." Nature Materials 8, no. 7 (2009): 543–57. http://dx.doi.org/10.1038/nmat2442.

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15

Pulido-Reyes, Gerardo, Francisco Leganes, Francisca Fernández-Piñas, and Roberto Rosal. "Bio-nano interface and environment: A critical review." Environmental Toxicology and Chemistry 36, no. 12 (2017): 3181–93. http://dx.doi.org/10.1002/etc.3924.

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16

Lin, Ziliang, Wenting Zhao, Lindsey Hanson, Chong Xie, Yi Cui, and Bianxiao Cui. "At the Nano-Bio Interface: Probing Live Cells with Nano Sensors." Biophysical Journal 106, no. 2 (2014): 225a. http://dx.doi.org/10.1016/j.bpj.2013.11.1318.

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17

Wang, Miaoyi, Ove J. R. Gustafsson, Emily H. Pilkington, et al. "Nanoparticle–proteome in vitro and in vivo." Journal of Materials Chemistry B 6, no. 38 (2018): 6026–41. http://dx.doi.org/10.1039/c8tb01634h.

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18

Zheng, Yongfang, Yuchen Lin, Yimin Zou, Yanlian Yang, and Chen Wang. "Peptide-/protein-mediated nano-bio interface and its applications." Chinese Science Bulletin 63, no. 35 (2018): 3783–98. http://dx.doi.org/10.1360/n972018-00835.

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19

Zhang, Liangliang, Xingcan Shen, Changchun Wen, Chunfang Wei, Hong Liang, and Shichen Ji. "SERS studies of the inorganic nano-bio interface interaction." SCIENTIA SINICA Chimica 47, no. 2 (2017): 183–90. http://dx.doi.org/10.1360/n032016-00153.

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20

Zhou, Ruhong, Thomas Weikl, and Yu-qiang Ma. "Theoretical modeling of interactions at the bio-nano interface." Nanoscale 12, no. 19 (2020): 10426–29. http://dx.doi.org/10.1039/d0nr90092c.

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21

Kumar, Rajiv, Chinenye Adaobi Igwegbe, and Shri Krishna Khandel. "Nanotherapeutic and Nano–Bio Interface for Regeneration and Healing." Biomedicines 12, no. 12 (2024): 2927. https://doi.org/10.3390/biomedicines12122927.

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Wound and injury healing processes are intricate and multifaceted, involving a sequence of events from coagulation to scar tissue formation. Effective wound management is crucial for achieving favorable clinical outcomes. Understanding the cellular and molecular mechanisms underlying wound healing, inflammation, and regeneration is essential for developing innovative therapeutics. This review explored the interplay of cellular and molecular processes contributing to wound healing, focusing on inflammation, innervation, angiogenesis, and the role of cell surface adhesion molecules. Additionally, it delved into the significance of calcium signaling in skeletal muscle regeneration and its implications for regenerative medicine. Furthermore, the therapeutic targeting of cellular senescence for long-term wound healing was discussed. The integration of cutting-edge technologies, such as quantitative imaging and computational modeling, has revolutionized the current approach of wound healing dynamics. The review also highlighted the role of nanotechnology in tissue engineering and regenerative medicine, particularly in the development of nanomaterials and nano–bio tools for promoting wound regeneration. Moreover, emerging nano–bio interfaces facilitate the efficient transport of biomolecules crucial for regeneration. Overall, this review provided insights into the cellular and molecular mechanisms of wound healing and regeneration, emphasizing the significance of interdisciplinary approaches and innovative technologies in advancing regenerative therapies. Through harnessing the potential of nanoparticles, bio-mimetic matrices, and scaffolds, regenerative medicine offers promising avenues for restoring damaged tissues with unparalleled precision and efficacy. This pursuit marks a significant departure from traditional approaches, offering promising avenues for addressing longstanding challenges in cellular and tissue repair, thereby significantly contributing to the advancement of regenerative medicine.
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22

Barkhade, Tejal, Ambadas Phatangare, Shailendra Dahiwale, Santosh Kumar Mahapatra, and Indrani Banerjee. "Nano‐bio interface study betweenFecontentTiO2nanoparticles and adenosine triphosphate biomolecules." Surface and Interface Analysis 51, no. 9 (2019): 894–905. http://dx.doi.org/10.1002/sia.6663.

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23

Hou, Ji-Dan, Yun-Ping Zhang, and Chun-Ju Tang. "New polymer nano-biomaterials in rehabilitation nursing of orthopedic surgery injuries." Materials Express 12, no. 1 (2022): 173–77. http://dx.doi.org/10.1166/mex.2022.2130.

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Changes in nano-bio materials’ surface electronic structure and crystal structure produce small-size effects that macroscopic objects do not have. This makes it have a series of excellent macroscopic properties such as force, magnetism, electricity, optics, chemistry, and biology that traditional materials do not have. This article studies the application of new polymer nano-bio materials in orthopedic trauma. We study the effect of nanolevel hydroxyapatite gradient coating on the expression of osteoblast phenotypic factors. The shear strength of the implant-bone interface is better than the titanium alloy group and the titanium alloy group. So we can conclude that the nano-grade hydroxyapatite gradient coating material has good biological characteristics. It can promote the early healing of the bone trauma interface. This material is worthy of clinical application.
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24

He, Xiaojia, Winfred G. Aker, Peter P. Fu, and Huey-Min Hwang. "Toxicity of engineered metal oxide nanomaterials mediated by nano–bio–eco–interactions: a review and perspective." Environmental Science: Nano 2, no. 6 (2015): 564–82. http://dx.doi.org/10.1039/c5en00094g.

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25

Harris, Alexander W., and Jennifer N. Cha. "Bridging bio-nano interactions with photoactive biohybrid energy systems." Molecular Systems Design & Engineering 5, no. 6 (2020): 1088–97. http://dx.doi.org/10.1039/d0me00031k.

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26

Lu, Chih-Hao, Christina E. Lee, Melissa L. Nakamoto, and Bianxiao Cui. "Cellular Signaling at the Nano-Bio Interface: Spotlighting Membrane Curvature." Annual Review of Physical Chemistry 76, no. 1 (2025): 251–77. https://doi.org/10.1146/annurev-physchem-090722-021151.

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No longer viewed as a passive consequence of cellular activities, membrane curvature—the physical shape of the cell membrane—is now recognized as an active constituent of biological processes. Nanoscale topographies on extracellular matrices or substrate surfaces impart well-defined membrane curvatures on the plasma membrane. This review examines biological events occurring at the nano-bio interface, the physical interface between the cell membrane and surface nanotopography, which activates intracellular signaling by recruiting curvature-sensing proteins. We encompass a wide range of biological processes at the nano-bio interface, including cell adhesion, endocytosis, glycocalyx redistribution, regulation of mechanosensitive ion channels, cell migration, and differentiation. Despite the diversity of processes, we call attention to the critical role of membrane curvature in each process. We particularly highlight studies that elucidate molecular mechanisms involving curvature-sensing proteins with the hope of providing comprehensive insights into this rapidly advancing area of research.
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27

Nanda, Sitansu Sekhar, and Dong Kee Yi. "Recent Advances in Synergistic Effect of Nanoparticles and Its Biomedical Application." International Journal of Molecular Sciences 25, no. 6 (2024): 3266. http://dx.doi.org/10.3390/ijms25063266.

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The synergistic impact of nanomaterials is critical for novel intracellular and/or subcellular drug delivery systems of minimal toxicity. This synergism results in a fundamental bio/nano interface interaction, which is discussed in terms of nanoparticle translocation, outer wrapping, embedding, and interior cellular attachment. The morphology, size, surface area, ligand chemistry and charge of nanoparticles all play a role in translocation. In this review, we suggest a generalized mechanism to characterize the bio/nano interface, as we discuss the synergistic interaction between nanoparticles and cells, tissues, and other biological systems. Novel perceptions are reviewed regarding the ability of nanoparticles to improve hybrid nanocarriers with homogeneous structures to enhance multifunctional biomedical applications, such as bioimaging, tissue engineering, immunotherapy, and phototherapy.
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28

Li, Jianhang, Guanbin Gao, Xintong Tang, Meng Yu, Meng He та Taolei Sun. "Isomeric Effect of Nano-Inhibitors on Aβ40 Fibrillation at The Nano-Bio Interface". ACS Applied Materials & Interfaces 13, № 4 (2021): 4894–904. http://dx.doi.org/10.1021/acsami.0c21906.

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29

Xie, Changjian, Junzhe Zhang, Yuhui Ma, et al. "Bacillus subtilis causes dissolution of ceria nanoparticles at the nano–bio interface." Environmental Science: Nano 6, no. 1 (2019): 216–23. http://dx.doi.org/10.1039/c8en01002a.

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30

Boruah, Jayanta S., Kamatchi Sankaranarayanan, and Devasish Chowdhury. "Insight into carbon quantum dot–vesicles interactions: role of functional groups." RSC Advances 12, no. 7 (2022): 4382–94. http://dx.doi.org/10.1039/d1ra08809b.

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An interaction study at the nano–bio interface involving phosphatidylcholine vesicles (as a model cell membrane) and four different carbon dots bearing different functional groups (–COOH, –NH2, –OH, and BSA-coated).
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31

Thomas, Spencer, Jeffrey Comer, Min Jung Kim, et al. "Comparative functional dynamics studies on the enzyme nano-bio interface." International Journal of Nanomedicine Volume 13 (August 2018): 4523–36. http://dx.doi.org/10.2147/ijn.s152222.

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32

Sanchez-Cano, Carlos, Ramon A. Alvarez-Puebla, John M. Abendroth, et al. "X-ray-Based Techniques to Study the Nano–Bio Interface." ACS Nano 15, no. 3 (2021): 3754–807. http://dx.doi.org/10.1021/acsnano.0c09563.

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33

Najafpour, Mohammad Mahdi, Mohadeseh Zarei Ghobadi, Anthony W. Larkum, Jian-Ren Shen, and Suleyman I. Allakhverdiev. "The biological water-oxidizing complex at the nano–bio interface." Trends in Plant Science 20, no. 9 (2015): 559–68. http://dx.doi.org/10.1016/j.tplants.2015.06.005.

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34

Campbell, Alan S., Chenbo Dong, Fanke Meng, et al. "Enzyme Catalytic Efficiency: A Function of Bio–Nano Interface Reactions." ACS Applied Materials & Interfaces 6, no. 8 (2014): 5393–403. http://dx.doi.org/10.1021/am500773g.

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35

Kwon, Sun Sang, Jae Hyeok Shin, Jonghyun Choi, SungWoo Nam, and Won Il Park. "Nanotube-on-graphene heterostructures for three-dimensional nano/bio-interface." Sensors and Actuators B: Chemical 254 (January 2018): 16–20. http://dx.doi.org/10.1016/j.snb.2017.07.058.

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36

El-Fatyany, Aya, Hongzhi Wang, Saied M. Abd El-atty, and Mehak Khan. "Biocyber Interface-Based Privacy for Internet of Bio-nano Things." Wireless Personal Communications 114, no. 2 (2020): 1465–83. http://dx.doi.org/10.1007/s11277-020-07433-9.

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37

Wang, Chunming, and Lei Dong. "Exploring ‘new’ bioactivities of polymers at the nano–bio interface." Trends in Biotechnology 33, no. 1 (2015): 10–14. http://dx.doi.org/10.1016/j.tibtech.2014.11.002.

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38

Yang, Celina, Darren Yohan, and Devika B. Chithrani. "Optimized bio-nano interface using peptide modified colloidal gold nanoparticles." Colloids and Interface Science Communications 1 (August 2014): 54–56. http://dx.doi.org/10.1016/j.colcom.2014.07.003.

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39

Zhang, Junzhe, Xiao He, Peng Zhang, et al. "Quantifying the dissolution of nanomaterials at the nano-bio interface." Science China Chemistry 58, no. 5 (2015): 761–67. http://dx.doi.org/10.1007/s11426-015-5401-2.

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40

Mout, Rubul, and Vincent M. Rotello. "Bio and Nano Working Together: Engineering the Protein-Nanoparticle Interface." Israel Journal of Chemistry 53, no. 8 (2013): 521–29. http://dx.doi.org/10.1002/ijch.201300026.

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41

Koumoulos, E. P., S. A. M. Tofail, C. Silien, et al. "Metrology and nano-mechanical tests for nano-manufacturing and nano-bio interface: Challenges & future perspectives." Materials & Design 137 (January 2018): 446–62. http://dx.doi.org/10.1016/j.matdes.2017.10.035.

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42

Caselli, Lucrezia, Andrea Ridolfi, Gaetano Mangiapia, et al. "Interaction of nanoparticles with lipid films: the role of symmetry and shape anisotropy." Physical Chemistry Chemical Physics 24, no. 5 (2022): 2762–76. http://dx.doi.org/10.1039/d1cp03201a.

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Topological effects are key in driving nano-bio interface phenomena: the symmetry of the lipid membrane (cubic or lamellar) dictates the interaction mechanism, while nanoparticles shape (sphere or rod) modulates the interaction strength.
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43

Tan, Angel, Yuen Yi Lam, Olivier Pacot, Adrian Hawley, and Ben J. Boyd. "Probing cell–nanoparticle (cubosome) interactions at the endothelial interface: do tissue dimension and flow matter?" Biomaterials Science 7, no. 8 (2019): 3460–70. http://dx.doi.org/10.1039/c9bm00243j.

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44

Wang, Wentao, and Hedi Mattoussi. "Engineering the Bio–Nano Interface Using a Multifunctional Coordinating Polymer Coating." Accounts of Chemical Research 53, no. 6 (2020): 1124–38. http://dx.doi.org/10.1021/acs.accounts.9b00641.

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45

Zhao, Lina. "Nano/bio interface study in peptide coated gold cluster nanomedicine design." Nanomedicine: Nanotechnology, Biology and Medicine 14, no. 5 (2018): 1791. http://dx.doi.org/10.1016/j.nano.2017.11.143.

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46

Verderio, Paolo, Svetlana Avvakumova, Giulia Alessio, et al. "Delivering Colloidal Nanoparticles to Mammalian Cells: A Nano-Bio Interface Perspective." Advanced Healthcare Materials 3, no. 7 (2014): 957–76. http://dx.doi.org/10.1002/adhm.201300602.

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47

Mehdinia, Meysam, Mohammad Farajollah Pour, Hossein Yousefi, Ali Dorieh, Anthony J. Lamanna, and Elham Fini. "Developing Bio-Nano Composites Using Cellulose-Nanofiber-Reinforced Epoxy." Journal of Composites Science 8, no. 7 (2024): 250. http://dx.doi.org/10.3390/jcs8070250.

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This study introduces the development of a novel bio-nano composite via the dispersion of cellulose nanofibers (CNF) in epoxy. The surface of cellulose nanofibers was functionalized using a two-step chemical treatment to enhance dispersion. The interfacial characteristics of CNF were improved using alcohol/acetone treatments. The modified CNF (M-CNF) demonstrated enhanced compatibility and improved dispersion in the epoxy matrix as evidenced by scanning electron microscopy. Based on the analysis of X-ray diffraction patterns, M-CNF did not disturb the crystalline phases at the interface. The results of mechanical testing showed that M-CNF worked as a reinforcing agent in the bio-nano composite. The flexural modulus increased from 1.4 to 3.7 GPa when M-CNF was introduced. A similar trend was observed for tensile strength and impact resistance. The optimum performance characteristics were observed at M-CNF of 0.6%. At higher dosages, some agglomeration was observed, which weakened the interfacial properties. This study promotes sustainability and resource conservation while offering CNF as a sustainable reinforcing agent to develop bio-nano composites.
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48

Imperlini, Esther, Christian Celia, Armando Cevenini, et al. "Nano-bio interface between human plasma and niosomes with different formulations indicates protein corona patterns for nanoparticle cell targeting and uptake." Nanoscale 13, no. 10 (2021): 5251–69. http://dx.doi.org/10.1039/d0nr07229j.

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49

Cohen-Karni, Tzahi, and Charles M. Lieber. "Nanowire nanoelectronics: Building interfaces with tissue and cells at the natural scale of biology." Pure and Applied Chemistry 85, no. 5 (2013): 883–901. http://dx.doi.org/10.1351/pac-con-12-10-19.

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The interface between nanoscale electronic devices and biological systems enables interactions at length scales natural to biology, and thus should maximize communication between these two diverse yet complementary systems. Moreover, nanostructures and nanostructured substrates show enhanced coupling to artificial membranes, cells, and tissue. Such nano–bio interfaces offer better sensitivity and spatial resolution as compared to conventional planar structures. In this work, we will report the electrical properties of silicon nanowires (SiNWs) interfaced with embryonic chicken hearts and cultured cardiomyocytes. We developed a scheme that allowed us to manipulate the nanoelectronic to tissue/cell interfaces while monitoring their electrical activity. In addition, by utilizing the bottom-up approach, we extended our work to the subcellular regime, and interfaced cells with the smallest reported device ever and thus exceeded the spatial and temporal resolution limits of other electrical recording techniques. The exceptional synthetic control and flexible assembly of nanowires (NWs) provides powerful tools for fundamental studies and applications in life science, and opens up the potential of merging active transistors with cells such that the distinction between nonliving and living systems is blurred.
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50

Kumar, Rajiv. "Biomedical applications of nanoscale tools and nano-bio interface: A blueprint of physical, chemical, and biochemical cues of cell mechanotransduction machinery." Biomedical Research and Clinical Reviews 4, no. 2 (2021): 01–04. http://dx.doi.org/10.31579/2692-9406/064.

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A dream to have control over the cell behavior by nanoscale tools and nano-bio interface to mimic remodeling of cell mechanotransduction machinery, is an updated approach and the latest theme of current research.[1] To achieve such a goal, the nanofabrication technique plays a key role in designing novel nanoscale tools capable of stimulating the natural extracellular matrix (ECM). These nano-bio tools can create a valuable nanoscale interface, and finally, these advanced tools control cell behavior. Structurally and compositionally, the cells are too complicated and well equipped with remarkable features. It has a lot of complexity in it. The initial hurdle is the natural composition of cells and the surroundings of the nanoscale. The cell is too complicated, and it is a difficult and tough task to determine the features of its areas. The emergence of nanoscale tools, which are capable of analyzing and performing by applying single-molecule with high precision is helping for boosting cellular events for enhancing biomedical claims.[2] These tools and biomedical methods consist of nanomaterials that can perform as nanodevices, expose the cellular environment and simulate the cell-matrix interface. These biomedical methods are now considered major outfits for further analysis. [3] To detect the surface patterning of the cells and concerned topographies of cellular environments, these nanoscale devices, and 3D microporous scaffolds derived from nanomaterials are the main equipment applied to exploit the hidden areas and undiscovered activities of the cell components.
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