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Journal articles on the topic 'Interferon-gamma/biosynthesis'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Boeve, Christine M. A., and Marc De Ley. "Modulation of Human Interferon-Gamma; Biosynthesis by Antisense Oligodeoxynucleotides." Molecular Biotechnology 14, no. 2 (2000): 157–64. http://dx.doi.org/10.1385/mb:14:2:157.

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Werner, E. R., G. Werner-Felmayer, D. Fuchs, A. Hausen, G. Reibnegger та H. Wachter. "Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-γ". Biochemical Journal 262, № 3 (1989): 861–66. http://dx.doi.org/10.1042/bj2620861.

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In all of eight tested human cells and cell lines with inducible indoleamine 2,3-dioxygenase (EC 1.13.11.17) tetrahydrobiopterin biosynthesis was activated by interferon-gamma. This was demonstrated by GTP cyclohydrolase I (EC 3.5.4.16) activities and intracellular neopterin and biopterin concentrations. Pteridine synthesis was influenced by extracellular tryptophan. In T 24-cell extracts, submillimolar concentrations of tetrahydrobiopterin stimulated the indoleamine 2,3-dioxygenase reaction.

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Boeve, C. M., A. V. Wyngaerd, and M. De Ley. "Inhibition of human interferon-gamma biosynthesis by an antisense RNA-expressing vector." Molecular Pharmacology 49, no. 1 (1996): 58–62. https://doi.org/10.1016/s0026-895x(25)08693-6.

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4

Reginato, A. M., C. Sanz-Rodriguez, A. Diaz, R. M. Dharmavaram та S. A. Jimenez. "Transcriptional modulation of cartilage-specific collagen gene expression by interferon γ and tumour necrosis factor α in cultured human chondrocytes". Biochemical Journal 294, № 3 (1993): 761–69. http://dx.doi.org/10.1042/bj2940761.

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To examine the possibility that cytokines produced in inflamed joint tissues may contribute to the loss of articular cartilage by causing inhibition of synthesis of cartilage-specific matrix macromolecules, we studied the effects of interferon gamma (IFN gamma) and tumour necrosis factor alpha (TNF alpha), alone and in combination, on the expression of the genes for types-II, -IX and -XI collagens in cultured human chondrocytes. Chondrocytes isolated from human fetal epiphyseal cartilage by sequential enzymic digestions were cultured in the presence of IFN gamma (30 pM), TNF alpha (15 pM) or a

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5

Luedke, C. E., and A. Cerami. "Interferon-gamma overcomes glucocorticoid suppression of cachectin/tumor necrosis factor biosynthesis by murine macrophages." Journal of Clinical Investigation 86, no. 4 (1990): 1234–40. http://dx.doi.org/10.1172/jci114829.

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6

Finbloom, D. S. "Regulation of cell-surface receptors for human interferon-γ on the human histiocytic lymphoma cell line U937". Biochemical Journal 274, № 3 (1991): 775–80. http://dx.doi.org/10.1042/bj2740775.

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Interferon-gamma (IFN gamma) binds to high-affinity receptors on monocytes and is rapidly internalized. This study investigates the ability of the human monocyte-like cell line, U937, to regulate the cell-surface expression of the IFN gamma receptor (IFN gamma R) during endocytosis of ligand. Recombinant IFN gamma was radiolabelled to high specific radioactivity with Bolton-Hunter reagent and used to enumerate IFN gamma R on treated U937 cells. Cells which had internalized IFN gamma for up to 3 h displayed maximal levels of IFN gamma R at all time points tested after all unlabelled IFN gamma h

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7

Kurzrock, R., M. F. Rohde, J. R. Quesada, et al. "Recombinant gamma interferon induces hypertriglyceridemia and inhibits post-heparin lipase activity in cancer patients." Journal of Experimental Medicine 164, no. 4 (1986): 1093–101. http://dx.doi.org/10.1084/jem.164.4.1093.

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Animals suffering from malignancy or chronic infection develop characteristic metabolic abnormalities, including a well-defined hypertriglyceridemic state. These abnormalities have been attributed to release of one or more mediators from activated macrophages. We report that cancer patients receiving RIFN-gamma, a potent macrophage activator, at doses of greater than or equal to 0.25 mg/m2/d i.m. show marked increases in triglyceride but not in cholesterol levels (pretreatment triglyceride level of 180 +/- 190 mg/dl [mean +/- SD] vs. a day-14 level of 370 +/- 242 mg/dl, n = 23, p less than 0.0

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BASHAM, TERESA Y., BRIAN J. NICKOLOFF, THOMAS C. MERIGAN, and VERA B. MORHENN. "Recombinant Gamma Interferon Differentially Regulates Class II Antigen Expression and Biosynthesis on Cultured Normal Human Keratinocytes." Journal of Interferon Research 5, no. 1 (1985): 23–32. http://dx.doi.org/10.1089/jir.1985.5.23.

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9

Drouet, C., A. Reboul, and M. Colomb. "Identification of a human non-interferon lymphokine activating monocyte complement biosynthesis." Biochemical Journal 263, no. 1 (1989): 157–64. http://dx.doi.org/10.1042/bj2630157.

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A monocyte-stimulating activity produced by mitogen-induced mononuclear cells has been defined by its ability to enhance the synthesis in vitro of complement C1 subcomponents, C2 and C3. A lymphokine responsible for this activity was purified from culture supernatants of peripheral blood mononuclear cells activated by staphylococcal enterotoxin A. From 0.5 litre of supernatant the purification procedure [(NH4)2SO4 precipitation, phenyl-Sepharose chromatography and preparative electrofocusing] yielded about 100 pmol of purified lymphokine. Its pI is 7.9 and its Mr, estimated by SDS/polyacrylami

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10

Patston, PA, RL Medcalf, Y. Kourteva, and M. Schapira. "C1-inhibitor-serine proteinase complexes and the biosynthesis of C1- inhibitor by Hep G2 and U 937 cells." Blood 82, no. 11 (1993): 3371–79. http://dx.doi.org/10.1182/blood.v82.11.3371.3371.

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Abstract The biosynthesis of the serpin alpha 1-proteinase inhibitor is regulated by a feedback mechanism whereby complexes between alpha 1- proteinase inhibitor and serine proteinases bind to liver cells and monocytes, a reaction that activates alpha 1-proteinase-inhibitor gene transcription. Such a mechanism may form the basis for the development of new therapeutic strategies for serpin deficiency states with reduced levels of otherwise normally functioning serpins. This issue was addressed for C1-inhibitor, the missing serpin in hereditary angioedema. C1-inhibitor biosynthesis by Hep G2 hep

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Patston, PA, RL Medcalf, Y. Kourteva, and M. Schapira. "C1-inhibitor-serine proteinase complexes and the biosynthesis of C1- inhibitor by Hep G2 and U 937 cells." Blood 82, no. 11 (1993): 3371–79. http://dx.doi.org/10.1182/blood.v82.11.3371.bloodjournal82113371.

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The biosynthesis of the serpin alpha 1-proteinase inhibitor is regulated by a feedback mechanism whereby complexes between alpha 1- proteinase inhibitor and serine proteinases bind to liver cells and monocytes, a reaction that activates alpha 1-proteinase-inhibitor gene transcription. Such a mechanism may form the basis for the development of new therapeutic strategies for serpin deficiency states with reduced levels of otherwise normally functioning serpins. This issue was addressed for C1-inhibitor, the missing serpin in hereditary angioedema. C1-inhibitor biosynthesis by Hep G2 hepatoma cel

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12

Sakai, N., K. Saito, S. Kaufman, M. P. Heyes, and S. Milstien. "Induction of pterin synthesis is not required for cytokine-stimulated tryptophan metabolism." Biochemical Journal 295, no. 2 (1993): 543–47. http://dx.doi.org/10.1042/bj2950543.

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Activation of the immune system which occurs in inflammatory disease leads to parallel increases in pterin synthesis and increased production of neuroactive L-tryptophan metabolites. Several model systems were studied to determine whether pterins, which are cofactors for hydroxylation reactions, could be required in the oxidative kynurenine pathway of L-tryptophan degradation. Treatment of mice with interferon-gamma increased L-tryptophan metabolism without any corresponding change in tissue biopterin concentrations. Cytokine-treated human fibroblasts, macrophages and glioblastoma cells all sh

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13

Werner, E. R., G. Werner-Felmayer, D. Fuchs та ін. "Impact of tumour necrosis factor-α and interferon-γ on tetrahydrobiopterin synthesis in murine fibroblasts and macrophages". Biochemical Journal 280, № 3 (1991): 709–14. http://dx.doi.org/10.1042/bj2800709.

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Tumour necrosis factor-alpha causes an up to 30-fold induction of GTP cyclohydrolase I (EC 3.5.4.16) activity in murine dermal fibroblasts in a dose-dependent manner. Owing to the high constitutive activities of 6-pyruvoyltetrahydropterin synthase and sepiapterin reductase (EC 1.1.1.153), this potentiates biosynthesis of tetrahydrobiopterin. Murine macrophages already contain high activities of GTP cyclohydrolase I when unstimulated, and this is further augmented up to 4-fold by tumour necrosis factor-alpha/interferon-gamma. In Western blots an antiserum to murine liver GTP cyclohydrolase I do

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Chu, Ping, Annette R. Rodriguez, Bernard P. Arulanandam, and Karl E. Klose. "Tryptophan Prototrophy Contributes to Francisella tularensis Evasion of Gamma Interferon-Mediated Host Defense." Infection and Immunity 79, no. 6 (2011): 2356–61. http://dx.doi.org/10.1128/iai.01349-10.

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ABSTRACTFrancisella tularensisis able to survive and replicate within host macrophages, a trait that is associated with the high virulence of this bacterium. ThetrpABgenes encode the enzymes required for the final two steps in tryptophan biosynthesis, with TrpB being responsible for the conversion of indole to tryptophan. Consistent with this function, anF. tularensissubsp.novicidatrpBmutant is unable to grow in defined medium in the absence of tryptophan. ThetrpBmutant is also attenuated for virulence in a mouse pulmonary model of tularemia. However, thetrpBmutant remains virulent in gamma in

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15

Kirksey, Meghan A., Anna D. Tischler, Roxane Siméone, et al. "Spontaneous Phthiocerol Dimycocerosate-Deficient Variants of Mycobacterium tuberculosis Are Susceptible to Gamma Interferon-Mediated Immunity." Infection and Immunity 79, no. 7 (2011): 2829–38. http://dx.doi.org/10.1128/iai.00097-11.

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ABSTRACTOnset of the adaptive immune response in mice infected withMycobacterium tuberculosisis accompanied by slowing of bacterial replication and establishment of a chronic infection. Stabilization of bacterial numbers during the chronic phase of infection is dependent on the activity of the gamma interferon (IFN-γ)-inducible nitric oxide synthase (NOS2). Previously, we described a differential signature-tagged mutagenesis screen designed to identifyM. tuberculosis“counterimmune” mechanisms and reported the isolation of three mutants in the H37Rv strain background containing transposon inser

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16

Mukhopadhyay, Sanghamitra, Richard D. Miller, Erin D. Sullivan, et al. "Protein Expression Profiles of Chlamydia pneumoniae in Models of Persistence versus Those of Heat Shock Stress Response." Infection and Immunity 74, no. 7 (2006): 3853–63. http://dx.doi.org/10.1128/iai.02104-05.

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ABSTRACT Chlamydia pneumoniae is an obligate intracellular pathogen that causes both acute and chronic human disease. Several in vitro models of chlamydial persistence have been established to mimic chlamydial persistence in vivo. We determined the expression patterns of 52 C. pneumoniae proteins, representing nine functional subgroups, from the gamma interferon (IFN-γ) treatment (primarily tryptophan limitation) and iron limitation (IL) models of persistence compared to those following heat shock (HS) at 42°C. Protein expression patterns of C. pneumoniae persistence indicates a strong stress

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17

Aliberti, Júlio C. S., Fabiana S. Machado, Ricardo T. Gazzinelli, Mauro M. Teixeira, and João S. Silva. "Platelet-Activating Factor Induces Nitric Oxide Synthesis in Trypanosoma cruzi-Infected Macrophages and Mediates Resistance to Parasite Infection in Mice." Infection and Immunity 67, no. 6 (1999): 2810–14. http://dx.doi.org/10.1128/iai.67.6.2810-2814.1999.

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ABSTRACT Trypanosoma cruzi replicates in nucleated cells and is susceptible to being killed by gamma interferon-activated macrophages through a mechanism dependent upon NO biosynthesis. In the present study, the role of platelet-activating factor (PAF) in the induction of NO synthesis and in the activation of the trypanocidal activity of macrophages was investigated. In vitro, PAF induced NO secretion byT. cruzi-infected macrophages and the secreted NO inhibited intracellular parasite growth. The addition of a PAF antagonist, WEB 2170, inhibited both NO biosynthesis and trypanocidal activity.

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18

Conrad, D. H., T. J. Waldschmidt, W. T. Lee, et al. "Effect of B cell stimulatory factor-1 (interleukin 4) on Fc epsilon and Fc gamma receptor expression on murine B lymphocytes and B cell lines." Journal of Immunology 139, no. 7 (1987): 2290–96. http://dx.doi.org/10.4049/jimmunol.139.7.2290.

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Abstract Culture of murine splenic B cells with interleukin 4 (IL-4) caused the up-regulation of the lymphocyte Fc receptor for immunoglobulin E (IgE) (Fc epsilon R) over a similar dose range as required for Ia up-regulation. However, the expression level of the Fc receptor for immunoglobulin G (Fc gamma R) did not increase, rather IL-4 caused a slight but consistent decrease in the Fc gamma R level on the B cells. Fc epsilon R+ B hybridoma cells also responded to IL-4 by exhibiting increased Fc epsilon R expression; with the hybridoma cells Fc gamma R levels were unaffected. IL-4 caused an in

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19

Shapiro, S. D., E. J. Campbell, D. K. Kobayashi, and H. G. Welgus. "Immune modulation of metalloproteinase production in human macrophages. Selective pretranslational suppression of interstitial collagenase and stromelysin biosynthesis by interferon-gamma." Journal of Clinical Investigation 86, no. 4 (1990): 1204–10. http://dx.doi.org/10.1172/jci114826.

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20

Araneo, BA, T. Dowell, M. Diegel, and RA Daynes. "Dihydrotestosterone exerts a depressive influence on the production of interleukin-4 (IL-4), IL-5, and gamma-interferon, but not IL-2 by activated murine T cells." Blood 78, no. 3 (1991): 688–99. http://dx.doi.org/10.1182/blood.v78.3.688.688.

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Abstract The present study examined the effects of the androgen steroid, dihydrotestosterone (DHT), on murine T-cell production of a number of lymphokines. Direct exposure of murine T cells to DHT in vitro was found to reduce the amount of interleukin-4 (IL-4), IL-5, and gamma- interferon (gamma IFN) produced after activation with anti-CD3 without affecting the production of IL-2. Exposure of T cells to either androstenedione or testosterone (the metabolic precursors of DHT) affected no change in the biosynthesis of either of these lymphokines. We have determined that macrophages possess 5 alp

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Araneo, BA, T. Dowell, M. Diegel, and RA Daynes. "Dihydrotestosterone exerts a depressive influence on the production of interleukin-4 (IL-4), IL-5, and gamma-interferon, but not IL-2 by activated murine T cells." Blood 78, no. 3 (1991): 688–99. http://dx.doi.org/10.1182/blood.v78.3.688.bloodjournal783688.

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The present study examined the effects of the androgen steroid, dihydrotestosterone (DHT), on murine T-cell production of a number of lymphokines. Direct exposure of murine T cells to DHT in vitro was found to reduce the amount of interleukin-4 (IL-4), IL-5, and gamma- interferon (gamma IFN) produced after activation with anti-CD3 without affecting the production of IL-2. Exposure of T cells to either androstenedione or testosterone (the metabolic precursors of DHT) affected no change in the biosynthesis of either of these lymphokines. We have determined that macrophages possess 5 alpha-reduct

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Platzer, E., B. Y. Rubin, L. Lu, K. Welte, H. E. Broxmeyer, and M. A. Moore. "OKT3 monoclonal antibody induces production of colony-stimulating factor(s) for granulocytes and macrophages in cultures of human T lymphocytes and adherent cells." Journal of Immunology 134, no. 1 (1985): 265–71. http://dx.doi.org/10.4049/jimmunol.134.1.265.

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Abstract OKT3 monoclonal antibody (mab) recognizes a membrane antigen associated with the T cell antigen recognition receptor, and is known to be mitogenic and to induce lymphokine production. Our studies demonstrate the ability of OKT3 mab to induce from cultures of human T lymphocytes supplemented with adherent cells the production of colony-stimulating factor(s) for granulocytes and macrophages (GM-CSF) and interferon-gamma (IFN-gamma), an inhibitor of clonal growth of hematopoietic progenitor cells. As has been shown for the mitogenic and IFN-gamma-inducing activity of OKT3 mab, the induct

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23

Falus, A., Katalin G. Fehér, Erzsébet Walcz, et al. "Hormonal regulation of complement biosynthesis in human cell lines—I. Androgens and gamma-interferon stimulate the biosynthesis and gene expression of C1 inhibitor in human cell lines U937 and HepG2." Molecular Immunology 27, no. 2 (1990): 191–95. http://dx.doi.org/10.1016/0161-5890(90)90114-f.

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24

Cersini, Antonella, Maria Celeste Martino, Irene Martini, Giacomo Rossi, and Maria Lina Bernardini. "Analysis of Virulence and Inflammatory Potential of Shigella flexneri Purine Biosynthesis Mutants." Infection and Immunity 71, no. 12 (2003): 7002–13. http://dx.doi.org/10.1128/iai.71.12.7002-7013.2003.

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ABSTRACT Several Shigella flexneri mutants with defects in aromatic amino acid and/or purine biosynthesis have been evaluated as vaccines in humans or in animal models. To be suitable as a vaccine, a mutant has to show virulence attenuation, minimal reactogenicity, and a good immunogenic potential in animal models. With this aim, we have constructed five S. flexneri 5 (wild-type strain M90T) mutants with inactivation of one or two of the loci purEK, purHD, and guaBA, governing early or late steps of purine biosynthesis. The mutants have been analyzed in vitro in cell cultures and in vivo in th

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Gütlich, M., E. Jaeger, K. P. Rücknagel, et al. "Human GTP cyclohydrolase I: only one out of three cDNA isoforms gives rise to the active enzyme." Biochemical Journal 302, no. 1 (1994): 215–21. http://dx.doi.org/10.1042/bj3020215.

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GTP cyclohydrolase I catalyses the first and rate-limiting step of tetrahydrobiopterin biosynthesis. Its expression is regulated by interferon-gamma or kit ligand in a tissue-specific manner. Three different cDNA forms have been reported for human GTP cyclohydrolase I [Togari, Ichinose, Matsumoto, Fujita and Nagatsu (1992) Biochem. Biophys. Res. Commun. 187, 359-365]. We have isolated, from a human liver cDNA library, two clones which contained inserts identical with two of the cDNAs reported by Togari et al. (1992). The three open reading frames corresponding to all reported cDNA sequences we

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Puthanmadhom Narayanan, Susrutha, Yufei Huang, and Taofeek K. Owonikoko. "Use of immune checkpoint gene (ICG) signatures to identify selective enrichment of FGL1 and CEACAM1 in histologic subtypes of lung cancer." Journal of Clinical Oncology 41, no. 16_suppl (2023): e20527-e20527. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e20527.

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e20527 Background: Immune checkpoint blockade has changed the management paradigm for lung cancer. Identification of vulnerable subsets using reliable predictive biomarkers is an area of unmet need. We systematically compared the pattern of expression of validated mediators of adaptive and innate immune response in clinical and histologic subsets of lung cancer using publicly available datasets. Methods: Gene expression data for lung adenocarcinoma (LUAD, N = 501) and and lung squamous cell carcinoma (LUSC, N = 491) was obtained from The Cancer Genome Atlas. We compared the expression of ICGs

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Billiar, T. R., R. D. Curran, B. G. Harbrecht, et al. "Association between synthesis and release of cGMP and nitric oxide biosynthesis by hepatocytes." American Journal of Physiology-Cell Physiology 262, no. 4 (1992): C1077—C1082. http://dx.doi.org/10.1152/ajpcell.1992.262.4.c1077.

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Hepatocytes are known to synthesize nitric oxide (NO) from L-arginine via an inducible NO synthase. Studies were performed to determine the relationship between hepatocyte NO production and the stimulation of hepatocyte soluble guanylate cyclase. A combination of lipopolysaccharide (LPS), interferon-gamma, tumor necrosis factor, and interleukin-1 stimulates the biosynthesis of large quantities of nitrite and nitrate (NO2- + NO3-). Hepatocyte NO2- + NO3- production was associated with only small increases in intracellular guanosine 3',5'-cyclic monophosphate (cGMP) levels but much greater incre

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Sareneva, Timo, Ejvind Mortz, Hannele Tolo, Peter Roepstorff, and Ilkka Julkunen. "Biosynthesis and N-glycosylation of Human Interferon-gamma. Asn25 and Asn97 Differ Markedly in How Efficiently They are Glycosylated and in Their Oligosaccharide Composition." European Journal of Biochemistry 242, no. 2 (1996): 191–200. http://dx.doi.org/10.1111/j.1432-1033.1996.0191r.x.

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Hoekstra, R., and D. Fekkes. "Pteridines and affective disorders." Acta Neuropsychiatrica 14, no. 3 (2002): 120–26. http://dx.doi.org/10.1034/j.1601-5215.2002.140305.x.

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The pteridine tetrahydrobiopterin (BH4) is an essential cofactor in the biosynthesis of dopamine, (nor)epinephrine, serotonin and nitric oxide (NO). Furthermore, BH4 has a direct influence on release mechanisms of these neurotransmitters and on serotonin receptor binding activity immunology. The synthesis of BH4 is stimulated by interferon-gamma and hence there is a close relationship with the immune system HPA-axis. In animal experiments it was also found that the hypothalamus–pituitary–adrenal axis influences the pteridine metabolism. In clinical studies, so far, no evidence has been found f

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Bisson, Gregory P., Carolina Mehaffy, Corey Broeckling, et al. "Upregulation of the Phthiocerol Dimycocerosate Biosynthetic Pathway by Rifampin-Resistant,rpoBMutant Mycobacterium tuberculosis." Journal of Bacteriology 194, no. 23 (2012): 6441–52. http://dx.doi.org/10.1128/jb.01013-12.

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ABSTRACTMultidrug-resistant tuberculosis has emerged as a major threat to tuberculosis control. Phylogenetically related rifampin-resistant actinomycetes with mutations mapping to clinically dominantMycobacterium tuberculosismutations in therpoBgene show upregulation of gene networks encoding secondary metabolites. We compared the expressed proteomes and metabolomes of two fully drug-susceptible clinical strains ofM. tuberculosis(wild type) to those of their respective rifampin-resistant,rpoBmutant progeny strains with confirmed rifampin monoresistance following antitubercular therapy. Each of

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Kitamura, Andoh, Inoue та ін. "Sodium butyrate blocks interferon-gamma (IFN-γ)-induced biosynthesis of MHC class III gene products (complement C4 and factor B) in human fetal intestinal epithelial cells". Clinical & Experimental Immunology 118, № 1 (1999): 16–22. http://dx.doi.org/10.1046/j.1365-2249.1999.01004.x.

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Nakayama, D. K., D. A. Geller, M. Di Silvio, et al. "Tetrahydrobiopterin synthesis and inducible nitric oxide production in pulmonary artery smooth muscle." American Journal of Physiology-Lung Cellular and Molecular Physiology 266, no. 4 (1994): L455—L460. http://dx.doi.org/10.1152/ajplung.1994.266.4.l455.

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We recently reported (Am. J. Respir. Cell Mol. Biol. 7: 471-476, 1992) that a mixture of lipopolysaccharide (LPS) and cytokines produced a time-dependent increase in mRNA and protein expression of inducible nitric oxide synthase (iNOS) in cultured rat pulmonary artery smooth muscle cells (RPASM). In the current study we extend observations on regulation of iNOS in RPASM by showing that de novo synthesis of tetrahydrobiopterin (BH4) is critical for LPS and cytokine-induced NO production. A mixture of LPS and the cytokines gamma-interferon, interleukin-1 beta, and tumor necrosis factor-alpha inc

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Mach, François. "Statins as novel immunomodulators: From cell to potential clinical benefit." Thrombosis and Haemostasis 90, no. 10 (2003): 607–10. http://dx.doi.org/10.1160/th03-04-0249.

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SummaryIn the last decades, substantial progress has been made in understanding the relationship between lipid disorders and prevention of cardiac ischemic disease. Statins competitively inhibit 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase, an enzyme crucial to cholesterol biosynthesis. Statins have long been thought to exert their benefits by reducing cholesterol synthesis, but the fact that mevalonate is the precursor of isoprenoids that regulate diverse cellular functions has led investigators to examine pleiotropic effects for these agents. Statins have never been shown to be

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Belmonte, Rodrigo, Tiehui Wang, Gary J. Duncan, et al. "Role of Pathogen-Derived Cell Wall Carbohydrates and Prostaglandin E2in Immune Response and Suppression of Fish Immunity by the Oomycete Saprolegnia parasitica." Infection and Immunity 82, no. 11 (2014): 4518–29. http://dx.doi.org/10.1128/iai.02196-14.

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ABSTRACTSaprolegnia parasiticais a freshwater oomycete that is capable of infecting several species of fin fish. Saprolegniosis, the disease caused by this microbe, has a substantial impact on Atlantic salmon aquaculture. No sustainable treatment against saprolegniosis is available, and little is known regarding the host response. In this study, we examined the immune response of Atlantic salmon toS. parasiticainfection and to its cell wall carbohydrates.Saprolegniatriggers a strong inflammatory response in its host (i.e., induction of interleukin-1β1[IL-1β1], IL-6, and tumor necrosis factor a

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Ramamoorthi, Ganesan, Marie Catherine Lee, Krithika Kodumudi, et al. "Abstract B038: CD4Th1 cytokine interferon gamma regulates genome profiles and inhibits tumorigenesis of disseminated cancer cells in breast cancer." Cancer Research 84, no. 3_Supplement_1 (2024): B038. http://dx.doi.org/10.1158/1538-7445.advbc23-b038.

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Abstract Detection and persistence of disseminated cancer cells (DCCs) in the bone marrow (BM) of breast cancer (BC) patients has been identified as a primary source for late recurrence and distant metastasis in multiple organs and the central nervous system. Selective targeting and eradication of DCCs in BM can be of a significant advantage to prevent future recurrence and enhance disease-free survival in BC patients. Unfortunately, no such targeted therapy presently exists. Instead, intense chemotherapy in the adjuvant or neoadjuvant setting are given with the ultimate goal to prevent DCC-dr

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Dustin, M. L., R. Rothlein, A. K. Bhan, C. A. Dinarello, and T. A. Springer. "Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1)." Journal of Immunology 137, no. 1 (1986): 245–54. http://dx.doi.org/10.4049/jimmunol.137.1.245.

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Abstract ICAM-1 is a cell surface glycoprotein originally defined by a monoclonal antibody (MAb) that inhibits phorbol ester-stimulated leukocyte aggregation. Staining of frozen sections and immunofluorescence flow cytometry showed intercellular adhesion molecule-1 (ICAM-1) is expressed on non-hematopoietic cells such as vascular endothelial cells, thymic epithelial cells, certain other epithelial cells, and fibroblasts, and on hematopoietic cells such as tissue macrophages, mitogen-stimulated T lymphocyte blasts, and germinal center dendritic cells in tonsils, lymph nodes, and Peyer's patches

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Beasley, D., and M. McGuiggin. "Interleukin 1 activates soluble guanylate cyclase in human vascular smooth muscle cells through a novel nitric oxide-independent pathway." Journal of Experimental Medicine 179, no. 1 (1994): 71–80. http://dx.doi.org/10.1084/jem.179.1.71.

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Recent demonstration of cytokine-inducible production of nitric oxide (NO) in vascular smooth muscle cells (VSMC) from rat aorta has implicated VSMC-derived NO as a key mediator of hypotension in septic shock. Our studies to determine whether an inducible NO pathway exists in human VSMC have revealed a novel cytokine-inducible, NO-independent pathway of guanylate cyclase activation in VSMC from human saphenous vein (HSVSMC). Interleukin 1 (IL-1), tumor necrosis factor (TNF), interferon gamma (IFN-gamma) and Escherichia coli lipopolysaccharide (LPS) increased cGMP at 24 h, whereas IL-2 and IL-6

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Razaghi, Ali, Roger Huerlimann, Leigh Owens та Kirsten Heimann. "Increased expression and secretion of recombinant hIFNγ through amino acid starvation-induced selective pressure on the adjacent HIS4 gene in Pichia pastoris". Acta Facultatis Pharmaceuticae Universitatis Comenianae 62, № 2 (2015): 43–50. http://dx.doi.org/10.1515/afpuc-2015-0031.

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Abstract Transcriptional co-regulation of adjacent genes has been observed for prokaryotic and eukaryotic organisms, alike. High levels of gene adjacency were also found in a wide variety of yeast species with a high frequency of co-regulated gene sets. The aim of this research was to study how selective pressure on the Histidinol dehydrogenase gene (HIS4), using amino acid starvation, affects the level of expression and secretion of the adjacent human interferon gamma gene (hIFNγ) in the recombinant Pichia pastoris GS115 strain, a histidine-deficient mutant. hIFNγ was cloned into the pPIC9 ve

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Zhao, Jianan, Haoliang Tian, Xiaohui Kong, et al. "Microbiomic and Metabolomic Insights into the Mechanisms of Alfalfa Polysaccharides and Seaweed Polysaccharides in Alleviating Diarrhea in Pre-Weaning Holstein Calves." Animals 15, no. 4 (2025): 485. https://doi.org/10.3390/ani15040485.

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Neonatal calves’ diarrhea, which can be severe enough to cause death, has a significant impact on the global cattle industry. In this study, alfalfa polysaccharides and seaweed polysaccharides were found to significantly improve the diarrhea condition in neonatal calves. To explore the underlying mechanisms, further microbiomic and metabolomic analyses were conducted. This study investigated the impact of alfalfa polysaccharides and seaweed polysaccharides on growth performance, serum metabolites, gut microbiota, and metabolomics in neonatal Holstein calves. A total of 24 newborn calves were r

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Senju, Satoru, Ken-ichi Iyama, Hironori Kudo, Shinichi Aizawa, and Yasuharu Nishimura. "Immunocytochemical Analyses and Targeted Gene Disruption of GTPBP1." Molecular and Cellular Biology 20, no. 17 (2000): 6195–200. http://dx.doi.org/10.1128/mcb.20.17.6195-6200.2000.

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ABSTRACT We previously identified a gene encoding a putative GTPase, GTPBP1, which is structurally related to elongation factor 1α, a key component of protein biosynthesis machinery. The primary structure of GTPBP1 is highly conserved between human and mouse (97% identical at the amino acid level). Expression of this gene is enhanced by gamma interferon in a monocytic cell line, THP-1. Although counterparts of this molecule in Caenorhabditis elegans and Ascaris suum have also been identified, the function of this molecule remains to be clarified. In the present study, our immunohistochemical a

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Hezema, Nehal Nassef, Marwa Moustafa Eltarahony, and Sara Ahmed Abdel Salam. "Therapeutic and antioxidant potential of bionanofactory Ochrobactrum sp.-mediated magnetite and zerovalent iron nanoparticles against acute experimental toxoplasmosis." PLOS Neglected Tropical Diseases 17, no. 10 (2023): e0011655. http://dx.doi.org/10.1371/journal.pntd.0011655.

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The control of toxoplasmosis, a rampant one health disease, has been focussed on conventional antitoxoplasmic agents with their adverse outcomes, including serious side effects, treatment failure and emergence of drug resistant strains. Nanobiotechnology may provide a strong impetus for versatile alternative therapies against toxoplasmosis. Bionanofactory Ochrobactrum sp. strain CNE2 was recruited for the biosynthesis of functionalized magnetite iron nanoparticles (MNPs) and nanozerovalent iron (nZVI) under aerobic and anaerobic conditions and their therapeutic efficacy was evaluated against a

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Dumont, F. J., R. G. Palfree, and L. Z. Coker. "Phenotypic changes induced by interferon in resting T cells: major enhancement of Ly-6 antigen expression." Journal of Immunology 137, no. 1 (1986): 201–10. http://dx.doi.org/10.4049/jimmunol.137.1.201.

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Abstract The murine Ly-6 locus controls multiple cell surface antigenic specificities with distinct cellular and tissue distributions. Although the functions of Ly-6 antigens are unknown, several of these antigens represent interesting markers of T cell differentiation and activation. In this work we used a panel of monoclonal antibodies (MAb) in conjunction with flow cytofluorometry (FCF) analysis to investigate the effect of interferon (IFN) on the surface representation of T cell-associated Ly-6 antigens. It was found that in vitro treatment of purified T cells from both C57Bl/6 (Ly-6.2) an

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Gupta, Bhawna, Emanuela M. Iancu, Philippe O. Gannon, et al. "Simultaneous coexpression of memory-related and effector-related genes by individual human CD8 T cells depends on antigen specificity and differentiation." Journal of Immunotherapy (hagerstown, Md. : 1997) 35, no. 6 (2012): 488–501. https://doi.org/10.1097/CJI.0b013e31826183a7.

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Phenotypic and functional cell properties are usually analyzed at the level of defined cell populations but not single cells. Yet, large differences between individual cells may have important functional consequences. It is likely that T-cell-mediated immunity depends on the polyfunctionality of individual T cells, rather than the sum of functions of responding T-cell subpopulations. We performed highly sensitive single-cell gene expression profiling, allowing the direct ex vivo characterization of individual virus-specific and tumor-specific T cells from healthy donors and melanoma patients.

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Beutler, B., V. Tkacenko, I. Milsark, N. Krochin, and A. Cerami. "Effect of gamma interferon on cachectin expression by mononuclear phagocytes. Reversal of the lpsd (endotoxin resistance) phenotype." Journal of Experimental Medicine 164, no. 5 (1986): 1791–96. http://dx.doi.org/10.1084/jem.164.5.1791.

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IFN-gamma permits the endotoxin-induced production of cachectin by C3H/HeJ (endotoxin resistant) macrophages, apparently by facilitating endotoxin-induced cachectin biosynthesis at both transcriptional and posttranscriptional levels. IFN-gamma cannot induce cachectin biosynthesis by itself, nor does it markedly enhance cachectin production by endotoxin-induced peritoneal macrophages obtained from endotoxin-responsive mice. Elucidation of the precise mechanism through which IFN-gamma influences cachectin biosynthesis may permit a better understanding of the molecular events that follow endotoxi

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Iversen, L., M. Svendsen, and K. Kragballe. "Cyclosporin A down-regulates the LTA4 hydrolase level in human keratinocyte cultures." Acta Dermato-Venereologica 76, no. 6 (1996): 424–28. http://dx.doi.org/10.2340/0001555576424428.

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Leukotriene A4 hydrolase is a key enzyme in the biosynthesis of leukotriene B4, a potent pro-inflammatory compound. The purpose of this study was to determine the capacity of antiinflammatory and anti-proliferative compounds to regulate the levels and activity of leukotriene A4 hydrolase in cultured human keratinocytes. The content of leukotriene A4 hydrolase was determined by Western blot analysis, and the activity of leukotriene A4 hydrolase was expressed as the leukotriene B4 formation after incubation of keratinocyte cultures with leukotriene A4. Leukotriene B4 was measured by revered-phas

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Finocchiaro, L. M. E., V. E. Nahmod, and J. M. Launay. "Melatonin biosynthesis and metabolism in peripheral blood mononuclear leucocytes." Biochemical Journal 280, no. 3 (1991): 727–31. http://dx.doi.org/10.1042/bj2800727.

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Cultured human peripheral blood mononuclear leucocytes (PBML) were able to synthesize indoleamines, including melatonin, and were also able to convert melatonin taken up from the incubation medium into N-acetyl-5-hydroxytryptamine (NAHT) and 5-hydroxytryptamine (5-HT). These compounds were analysed by h.p.l.c., and melatonin was additionally characterized by two-dimensional t.l.c., mass spectrometry and radioimmunoassay. Only hydroxyindoles were detected by h.p.l.c. in unstimulated PBML culture. Sustained stimulation by melatonin or interferon-gamma (IFN-gamma) increased markedly the basal pro

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Luster, A. D., and J. V. Ravetch. "Biochemical characterization of a gamma interferon-inducible cytokine (IP-10)." Journal of Experimental Medicine 166, no. 4 (1987): 1084–97. http://dx.doi.org/10.1084/jem.166.4.1084.

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An IFN-gamma-inducible protein, IP-10, has previously been described to belong to a gene family of chemotactic and mitogenic proteins, associated with inflammation and proliferation. Biochemical characterization of this predicted protein has been pursued through the development of polyclonal monospecific antisera to recombinant protein and synthetic peptides. These reagents establish that the IP-10 protein is secreted from a variety of cells (endothelial, monocyte, fibroblast, and keratinocyte) in response to IFN-gamma. Posttranslational processing occurs in the biosynthesis of this protein, r

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Christofyllakis, Konstantinos, Frank Neumann, Stephan Stilgenbauer, et al. "Gene Set Enrichment Analysis Suggests That Increased Rituximab-Mediated NK Cell Cytotoxicity after Vitamin D Substitution Is Driven By Upregulation of Interferon Alpha (IFN-a) Isoforms." Blood 132, Supplement 1 (2018): 3696. http://dx.doi.org/10.1182/blood-2018-99-111817.

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Abstract Introduction: We recently showed that vitamin D deficiency leads to decreased overall survival of DLBCL-patients treated with rituximab-chemotherapy (Bittenbring et al, JCO, 2014). We hypothesized that rituximab-mediated NK cell-cytotoxicity is more effective at higher vitamin D levels. This was confirmed by vitamin D substitution of healthy volunteers, which increased their rituximab-mediated cytotoxicity in vitro against the Daudi lymphoma cell line. To unveil the molecular mechanisms behind this finding, resting NK cells before and after vitamin D supplementation were isolated from

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Potenza, Leonardo, Daniela Vallerini, Patrizia Barozzi, et al. "Protective T-Cell Responses to Several Recombinant Aspergillus Antigens May Be Detected Since the Onset of the Infection in Patients with Invasive Aspergillosis, and May Be Exploited for Therapeutic Purposes,." Blood 118, no. 21 (2011): 3229. http://dx.doi.org/10.1182/blood.v118.21.3229.3229.

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Abstract Abstract 3229 Introduction: Several studies have reported that different components of fungi of the genera Aspergillus spp may induce protective T-cell responses in either mouse models of invasive aspergillosis (IA) or in human healthy subjects. We evaluated the occurrence of Aspergillus-specific T-cell responses to different Aspergillus recombinant antigens in patients with proven IA, during the course of the IA, to identify the antigens most frequently targeted by protective immune responses. We characterized phenotypically and functionally such specific T cells. Finally, from perip

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Karabela, Sophia, Chrysoula Kairi, Sophia Magkouta, et al. "Neutralization of tumor necrosis factor bioactivity ameliorates urethane-induced pulmonary oncogenesis in mice." Neoplasia (New York, N.Y.) 13, no. 12 (2011): 1143–51. https://doi.org/10.1593/neo.111224.

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Tumor necrosis factor (TNF) has been implicated in inflammation-associated tumor progression. Although multiple reports identified a role for TNF signaling in established cancers, few studies have assessed the impact of TNF blockade on early tumor formation promotion. We aimed at exploring the effects of TNF neutralization in a preclinical mouse model of lung carcinogenesis. For this, Balb/c mice (n = 42) received four weekly intraperitoneal urethane injections (1 g/kg) and twice-weekly intraperitoneal soluble TNF receptor (etanercept; 10 mg/kg) administered during tumor initiation/promotion,

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