Relevant bibliographies by topics / Interferon Gamma Release Assay (IGRA)

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Interferon Gamma Release Assay (IGRA)'

Author: Grafiati
Published: 4 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Interferon Gamma Release Assay (IGRA)"

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Rahman, Samra, Muhammad Irfan, and M. A. Rehman Siddiqui. "Role of interferon gamma release assay in the diagnosis and management of Mycobacterium tuberculosis-associated uveitis: a review." BMJ Open Ophthalmology 6, no. 1 (2021): e000663. http://dx.doi.org/10.1136/bmjophth-2020-000663.

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Tuberculosis (TB)-associated uveitis is a common cause of infectious uveitis in the developing world. Diagnosis of TB uveitis remains a challenge. The role of interferon gamma release assays (IGRAs) is uncertain. Herein we summarise the available literature on the utility of IGRAs in the diagnosis and management of TB uveitis. We searched PubMed database from 1 August 2010 to 31 July 2020 using the following keywords alone and in combination: ‘interferon-gamma release assay’, ‘QuantiFERON’, ‘T-SPOT.TB’, ‘TB uveitis’, ‘serpiginous like choroiditis’, ‘tuberculoma’, ‘TB vasculitis’, ‘TB panuveiti
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Tabatneck, Mary, Jeffrey Campbell, Mingwei Sun, et al. "655. Patterns of Interferon-Gamma Release Assay (IGRA) Testing for Tuberculosis in Patients Less Than 2 Years Old." Open Forum Infectious Diseases 8, Supplement_1 (2021): S429—S430. http://dx.doi.org/10.1093/ofid/ofab466.852.

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Abstract Background The American Academy of Pediatrics recommends use of Interferon-Gamma Release Assays (IGRAs) to diagnose tuberculosis (TB) infection in patients ≥2 years old. However, IGRAs are not currently recommended in younger patients due to limited data and concerns of invalid/indeterminate test results, which occur if there is a positive or negative control failure. We sought to characterize the patterns of IGRA use in clinical practice and results of IGRAs in patients < 2 years old. Methods We conducted a retrospective cohort study of children < 2 years old at two lar
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Thomason, Jenna L., Uchechukwu M. Obih, David M. Koelle, Christian Lood, and and Grant Hughes. "An interferon-gamma release assay as a novel biomarker in systemic lupus erythematosus." Rheumatology 59, no. 11 (2020): 3479–87. http://dx.doi.org/10.1093/rheumatology/keaa161.

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Abstract Objective The mycobacterium tuberculosis (TB) IFN-γ release assay (TB-IGRA) assesses peripheral blood cell release of IFN-γ upon ex vivo exposure to mitogen (IGRA-MT), TB antigen or a negative/nil control (IGRA-NL); IGRA-NL is a measure of spontaneous IFN-γ release (SIR). Here, we investigate the diagnostic associations of elevated SIR and the potential use of IGRA-NL as a novel biomarker in SLE. Methods We analysed diagnostic code frequencies among 11 823 individuals undergoing TB-IGRA testing between 2010 and 2015 in a large urban US health-care system. To study the relationship bet
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Vassilopoulos, Dimitrios, Stamatoula Tsikrika, Chrisoula Hatzara, et al. "Comparison of Two Gamma Interferon Release Assays and Tuberculin Skin Testing for Tuberculosis Screening in a Cohort of Patients with Rheumatic Diseases Starting Anti-Tumor Necrosis Factor Therapy." Clinical and Vaccine Immunology 18, no. 12 (2011): 2102–8. http://dx.doi.org/10.1128/cvi.05299-11.

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ABSTRACTGamma interferon release assays (IGRAs) are increasingly used for latentMycobacterium tuberculosisinfection (LTBI) screening in patients with rheumatic diseases starting anti-tumor necrosis factor (anti-TNF) therapies. We compared the performances of two IGRAs, an enzyme-linked immunospot release assay (T-SPOT.TB) and an enzyme-linked immunosorbent assay (QuantiFERON-TB Gold In Tube [QFT-GIT]), to that of tuberculin skin testing (TST) for LTBI screening of 157 consecutive rheumatic patients starting anti-TNF therapies. Among 155 patients with valid results, 58 (37%) were positive by TS
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Kim, Keun Ju, Seong-Eun Ryu, Ha-Na Lee, Seung-Hwan Oh, and Chulhun L. Chang. "Evaluation of a New Chemiluminescent Immunoassay-Based Interferon-Gamma Release Assay for Detection of Latent Tuberculosis Infection." Medicina 59, no. 10 (2023): 1734. http://dx.doi.org/10.3390/medicina59101734.

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Background and Objectives: This study aimed to evaluate the performance of a new chemiluminescent immunoassay-based tuberculosis (TB) interferon-gamma release assay (IGRA), AdvanSureI3 TB-IGRA (LG Chem Ltd., Seoul, Republic of Korea), for detecting latent tuberculosis infection in comparison with T-SPOT.TB (Oxford Immunotec, Oxford, UK). Materials and Methods: Between June 2021 and December 2021, 125 non-duplicate blood specimens were collected from adult volunteers; each subject received both tests concurrently. Total agreement and Cohen’s kappa coefficient (κ) were used to calculate concorda
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Campbell, Jeffrey, Mingwei Sun, Wei He, et al. "646. Increasing Use of Interferon-Gamma Release Assay to Test for Pediatric Tuberculosis in a Low-Burden Setting." Open Forum Infectious Diseases 8, Supplement_1 (2021): S425. http://dx.doi.org/10.1093/ofid/ofab466.843.

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Abstract Background The American Academy of Pediatrics recommends tuberculin skin tests (TSTs) or interferon gamma release assays (IGRAs) to test for tuberculosis (TB) infection in children ≥2 years old, and prioritizes IGRA testing in Bacille Calmette-Guérin vaccine recipients due to cross-reactivity. TSTs require a return visit, which frequently results in loss to follow up. Growing evidence supports accuracy of IGRA testing in pediatric patients, including young children, leading to calls for preferential use of IGRA over TST. We sought to evaluate trends in IGRA use in children over time.
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Oliveira, Sandra Maria do Valle Leone de, Anete Trajman, Anamaria Mello Miranda Paniago, et al. "Frequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals." Jornal Brasileiro de Pneumologia 43, no. 3 (2017): 215–18. http://dx.doi.org/10.1590/s1806-37562016000000125.

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ABSTRACT Objective: To evaluate the frequency of and factors associated with indeterminate interferon-gamma release assay (IGRA) results in people living with HIV/AIDS (PLWHA). Methods: We tested 81 PLWHA in the central-west region of Brazil, using the tuberculin skin test and an IGRA. Information on sociodemographic and clinical variables was gathered through the use of questionnaires and from medical records. The association of those variables with indeterminate results was analyzed by calculating the adjusted ORs in a multivariate logistic regression model. Concordance was evaluated by dete
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Banaei, Niaz, Rajiv L. Gaur, and Madhukar Pai. "Interferon Gamma Release Assays for Latent Tuberculosis: What Are the Sources of Variability?" Journal of Clinical Microbiology 54, no. 4 (2016): 845–50. http://dx.doi.org/10.1128/jcm.02803-15.

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Interferon gamma release assays (IGRAs) are blood-based tests intended for diagnosis of latent tuberculosis infection (LTBI). IGRAs offer logistical advantages and are supposed to offer improved specificity over the tuberculin skin test (TST). However, recent serial testing studies of low-risk individuals have revealed higher false conversion rates with IGRAs than with TST. Reproducibility studies have identified various sources of variability that contribute to nonreproducible results. Sources of variability can be broadly classified as preanalytical, analytical, postanalytical, manufacturing
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Franken, Willeke P. J., Ben F. P. J. Koster, Ailko W. J. Bossink, et al. "Follow-Up Study of Tuberculosis-Exposed Supermarket Customers with Negative Tuberculin Skin Test Results in Association with Positive Gamma Interferon Release Assay Results." Clinical and Vaccine Immunology 14, no. 9 (2007): 1239–41. http://dx.doi.org/10.1128/cvi.00185-07.

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ABSTRACT We report a follow-up study of 29 subjects with negative tuberculin skin test (TST) results in association with positive gamma interferon release assay (IGRA) results, mainly due to responses to CFP-10 in the T-SPOT.TB assay, during a contact investigation. One year later, 12/29 subjects (41%) had converted to positive TST results in association with negative IGRA results.
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Jurčev-Savičević, Anamarija, Vera Katalinić-Janković, Kornelija Miše, and Ivan Gudelj. "The Role of Interferon-gamma Release Assay in Tuberculosis Control." Archives of Industrial Hygiene and Toxicology 63, no. 1 (2012): 49–59. http://dx.doi.org/10.2478/10004-1254-63-2012-2134.

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The Role of Interferon-gamma Release Assay in Tuberculosis ControlTuberculosis is still one of the major global public health threats. Countries with low incidence must focus on exhausting the reservoir of future cases by preventing reactivation. Therefore, it is important to identify and effectively treat those individuals who have latent tuberculosis infection and who may develop active disease. The tuberculin skin test has been the standard for detection of immune response against M. tuberculosis since the beginning of the 20th century. The new millennium has brought advancement in the diag
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Dissertations / Theses on the topic "Interferon Gamma Release Assay (IGRA)"

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Herzer, ThaÃs LÃbo. "InfecÃÃo latente por mycobacterium tuberculosis em portadores de infecÃÃo por HIV/AIDS: anÃlise atravÃs do uso de teste tuberculÃnico e teste de liberaÃÃo de interferon-gama." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7821.

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As pessoas vivendo com HIV tÃm probabilidade aumentada de desenvolver, apresentar formar graves, ter cepas multirresistentes e morrer por tuberculose. A profilaxia para infecÃÃo latente por Mycobacteium tuberculosis (ILTB) diminui a chance de ativaÃÃo de tuberculose (TB) numa mÃdia de 62% nessa populaÃÃo. Entretanto, o diagnÃstico da TB na sua forma latente à controverso. O teste tuberculÃnico (TT) à o Ãnico exame aprovado no Brasil para avaliaÃÃo dessa infecÃÃo, embora existam problemas tanto na sua realizaÃÃo quanto na sua interpretaÃÃo. Exames de liberaÃÃo de interferon-gama foram criados r
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Truffot, Aurélie. "Place des nouveaux biomarqueurs virologiques, immunologiques et pharmacologiques dans le suivi et la prédiction des infections virales opportunistes chez les patients transplantés rénaux." Electronic Thesis or Diss., Université Grenoble Alpes, 2025. http://www.theses.fr/2025GRALV006.

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Après une greffe rénale, l’administration d’immunosuppresseurs pour prévenir les rejets de greffe, tout en évitant un risque d’infections opportunistes, est un challenge constant. Des outils biologiques permettent de guider ces adaptations, avec sur le plan infectieux l’évaluation de l’immunité humorale (sérologies) et le suivi des charges virales (cytomégalovirus (CMV), polyomavirus BK (BKV) et Epstein-Barr virus (EBV)). Toutefois, ces outils restent insuffisants pour prédire le risque infectieux. L’apparition de nouveaux immunosuppresseurs, comme le belatacept (BELA), complexifie encore cett
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Stebler, Ariane. "Whole-blood interferon-gamma release assay for baseline tuberculosis screening among healthcare workers of a Swiss university hospital /." [S.l.] : [s.n.], 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000277049.

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Oren, E., M. H. Fiero, E. Barrett, B. Anderson, M. Nuῆez, and F. Gonzalez-Salazar. "Detection of latent tuberculosis infection among migrant farmworkers along the US-Mexico border." BIOMED CENTRAL LTD, 2016. http://hdl.handle.net/10150/622064.

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Background: Migrant farmworkers are among the highest-risk populations for latent TB infection (LTBI) in the United States with numerous barriers to healthcare access and increased vulnerability to infectious diseases. LTBI is usually diagnosed on the border using the tuberculin skin test (TST). QuantiFERON-TB Gold In-Tube (QFT-GIT) also measures immune response against specific Mycobacterium tuberculosis antigens. The objective of this study is to assess the comparability of TST and QFT-GIT to detect LTBI among migrant farmworkers on the border, as well as to examine the effects of various de
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Rogerson, Thomas Edward. "Evidence based testing and outcomes in transplantation." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/12859.

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The use of diagnostic tests is central to the practice of modern medicine, but knowing which test to use, and when, can be problematic. To make evidence-based diagnoses, clinicians need efficient ways of accessing diagnostic studies, interpreting the results of several studies, and checking the applicability of studies to their own setting. The aim of this thesis was to explore solutions to these problems by addressing a specific clinical question; What is the best screening test for latent tuberculosis in patients undergoing transplantation? In a study of diagnostic filter performance in MED
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Wyndham-Thomas, Chloe. "Screening for latent M. tuberculosis infection in HIV-positive patients residing in low tuberculosis incidence settings: Investigation of the current practices and identification of clinical- and immune-based strategies for improvement." Doctoral thesis, Universite Libre de Bruxelles, 2016. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/241270.

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Tuberculosis (TB) remains the main cause of death in people living with HIV (PLHIV). Indeed, PLHIV have a 20-30% greater risk of developing TB compared to HIV-uninfected subjects and have lower TB treatment success rates. In 2014, among the 9.6 million incident cases of TB reported worldwide, 12% occurred in PLHIV and 0.4 million deaths from HIV-associated TB were recorded.Mycobacterium tuberculosis is the main etiological agent for TB. For a majority of individuals, the immune response upon infection by M. tuberculosis is sufficient to prevent the development of disease, but insufficient to c
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Parsons, Sven David Charles. "Natural animal model systems to study tuberculosis." Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/4505.

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Thesis (PhD (Molecular Biology and Human Genetics))--University of Stellenbosch, 2010.<br>ENGLISH ABSTRACT: The growing global epidemic of human tuberculosis (TB) results in 8 million new cases of this disease and 2 million deaths annually. Control thereof will require greater insight into the biology of the causative organism, Mycobacterium tuberculosis, and into the pathogenesis of the disease. This will benefit the design of new vaccines and diagnostic assays which may reduce the degree of both disease transmission and progression. Animal models have played a vital role in the understandin
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FIORIO, SILVIA. "ANALISI DI UNA NUOVA METODICA DI LABORATORIO PER LO STUDIO DELLA RISPOSTA IMMUNOLOGICA ALL’INFEZIONE LATENTE DA MYCOBACTERIUM TUBERCULOSIS." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3426530.

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Identification and treatment of individuals with latent tuberculosis infection (LTBI) is an important component of tuberculosis elimination strategies in low incidence countries. In this context, health care workers (HCWs) represent an important target population for LTBI screening programmes and serial testing is recommended for HCWs. Interferon–gamma release assays (IGRAs) are alternatives to the tuberculin skin test (TST) and have been recommended for serial testing, but data are scarce on the interpretation of repeated IGRAs results. Existing studies, although limited, suggest that convers
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FIORIO, SILVIA. "ANALISI DI UNA NUOVA METODICA DI LABORATORIO PER LO STUDIO DELLA RISPOSTA IMMUNOLOGICA ALL'INFEZIONE LATENTE DA MYCOBACTERIUM TUBERCULOSIS." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3426531.

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Identification and treatment of individuals with latent tuberculosis infection (LTBI) is an important component of tuberculosis elimination strategies in low incidence countries. In this context, health care workers (HCWs) represent an important target population for LTBI screening programmes and serial testing is recommended for HCWs. Interferon-gamma release assays (IGRAs) are alternatives to the tuberculin skin test (TST) and have been recommended for serial testing, but data are scarce on the interpretation of repeated IGRAs results. Existing studies, although limited, suggest that convers
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Afonso, Alexandre Augusto Bernardo. "Comparação entre registos do teste tuberculínico no passado e "interferon gamma realease assay" atual em profissionais de saúde expostos em contexto hospitalar." Master's thesis, 2021. http://hdl.handle.net/10316/98778.

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Dissertação de Mestrado em Saúde Ocupacional apresentada à Faculdade de Medicina<br>Introdução: A tuberculose é uma das doenças infeciosas mais antigas conhecida desde o século XIX, que atinge centenas de milhares de pessoas anualmente e é uma causa de morte importante em todo o mundo. Infeta predominantemente os pulmões, mas também pode atingir outros órgãos, nomeadamente pele, ossos, rins, pericárdio, entre outros. A transmissão ocorre geralmente por disseminação de aerossóis produzidos por doentes com tuberculose pulmonar infeciosa. O controlo da doença e sua transmissão assentam na rápida
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Book chapters on the topic "Interferon Gamma Release Assay (IGRA)"

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Fairley, Jessica, and Indi Rasaratnam. "Beware of the Indeterminate Interferon-Gamma Release Assay (IGRA) Tuberculosis Test." In Beyond Evidence-Based Medicine. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-4440-8_114.

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Citerio, G., C. Giussani, Hugo Sax, et al. "Interferon Gamma Release Assays (IGRAs)." In Encyclopedia of Intensive Care Medicine. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_3175.

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Peter, Matuku-Kisaumbi. "The Role of TB Biomarkers in Diagnosis, Prognosis and Prevention of Tuberculosis." In Infectious Diseases. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.115129.

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This chapter focuses on how biomarkers of tuberculosis can be utilized in the diagnosis, prognosis and treatment monitoring of TB. Tuberculosis biomarkers are measurable molecular indicators present and/or whose levels are altered in disease states. Found in blood, urine, bronchoalveolar lavage or sputum, biomarkers can originate from the bacteria (e.g. Ag85, lipoarabinomannan (LAM) and bacterial DNA) or from the host (e.g. cytokines/chemokines, metabolites, transcriptomics, mixed signatures and other proteins). Despite the lack of tuberculous specificity, Ag85 can facilitate early detection o
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"Interferon-Gamma Release Assay." In Handbook of Disease Burdens and Quality of Life Measures. Springer New York, 2010. http://dx.doi.org/10.1007/978-0-387-78665-0_5929.

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Conference papers on the topic "Interferon Gamma Release Assay (IGRA)"

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Gebhardt, A., M. Barker, S. Polsfuß, R. Otto-Knapp, H. Rüssmann, and TT Bauer. "Der Stellenwert des EBUS bei Patienten mit reaktivem Interferon Gamma Release Assay (IGRA)." In 61. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e.V. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0039-3403126.

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Gupta, Dheeraj, Sachin Kumar, Indu Verma, and Ritesh Agarwal. "Interferon Gamma Release Assay (IGRA) in Sarcoidosis Patients From A High Tuberculosis (TB) Prevalence Country." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2366.

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Pegatin, Beatriz Furtado, MÁRJORIE DE ASSIS GOLIM, ALINE MÁRCIA MARQUES BRAZ, and RUI SEABRA FERREIRA JÚNIOR. "CARACTERIZAÇÃO DA FISIOPATOLOGIA DA TUBERCULOSE LATENTE E SEU DIAGNÓSTICO UTILIZANDO INTERFERON-GAMMA RELEASE ASSAY (IGRA)." In V Congresso Brasileiro de Imunologia. Revista Multidisciplinar em Saúde, 2025. https://doi.org/10.51161/v-conbrai/50581.

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Dharmagunawardena, Ruvini T., Hannah Jarvis, Jennifer Parker, et al. "What Happens When Blood TB Interferon Gamma Release Assays (IGRA) Are Available In Routine Clinical Practice." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a1191.

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Lisker, Gita. "Discrepancy Between Tuberculin Skin Testing (TST) And Interferon Gamma Release Assay (IGRA) Among New York Health-care Workers: A Case Series." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1763.

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Chandrapalan, Subashini, Ashwin Rajhan, Sven Lehm, Sarah Goddard, and Amanda Middleton. "Implementing an IGRA (interferon-gamma release assay) based TB screening pathway prior to starting biological treatments – Experience from a UK university hospital." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa2743.

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Jethani, Varuna, Girish Sindhwani, Aarti Raghuvanshi, Vinit Mehrotra, and Rakhee Khanduri. "Comparison of diagnostic utility of pleural fluid ADA and interferon-gamma release assay (IGRA) in differentiating tubercular and non-tubercular exudative pleural effusion." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa1534.

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Castro, SM, DPG Hubner, and LA Azevedo. "VALIDAÇÃO DO TESTE IGRA NO DIAGNÓSTICO DE INFECÇÃO LATENTE POR MYCOBACTERIUM TUBERCULOSIS EM UM LABORATÓRIO DA REDE PÚBLICA DE PORTO ALEGRE." In Resumos do 55º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s2.8261.

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Objetivo: A infecção latente pelo Mycobacterium tuberculosis (ILTB) é definida como um estado de resposta imune persistente à estimulação por antígenos de M. tuberculosis (MTB) sem sintomas clínicos ou achados radiológicos de doença ativa. A importância de diagnosticar a ILTB reside no potencial de reativação para a doença ativa e transmissível, quando o indivíduo estiver imunossuprimido com comorbidades ou em terapia biológica. Quando identificado o potencial de desenvolvimento de doença ativa em um indivíduo com ILTB, é recomendada a realização do tratamento preconizado, de forma a impedir q
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Kerks, Jennifer, Callum Gandolfi, Harmesh Moudgil, et al. "A retrospective study of the indications for the use of interferon gamma release assays (IGRA) in a United Kingdom (UK) district general hospital (DGH) tuberculosis (TB) clinic." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa2968.

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Hendrickse, Thomas, Joanna Gallagher, Dilip S. Nazareth, and Peter D. O. Davies. "Interferon Gamma Release Assays (IGRAs) For The Detection Of Latent Tuberculosis Infection (LTBI)." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4731.

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