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Journal articles on the topic 'Interferon Gamma Release Assay (IGRA)'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Rahman, Samra, Muhammad Irfan, and M. A. Rehman Siddiqui. "Role of interferon gamma release assay in the diagnosis and management of Mycobacterium tuberculosis-associated uveitis: a review." BMJ Open Ophthalmology 6, no. 1 (2021): e000663. http://dx.doi.org/10.1136/bmjophth-2020-000663.

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Tuberculosis (TB)-associated uveitis is a common cause of infectious uveitis in the developing world. Diagnosis of TB uveitis remains a challenge. The role of interferon gamma release assays (IGRAs) is uncertain. Herein we summarise the available literature on the utility of IGRAs in the diagnosis and management of TB uveitis. We searched PubMed database from 1 August 2010 to 31 July 2020 using the following keywords alone and in combination: ‘interferon-gamma release assay’, ‘QuantiFERON’, ‘T-SPOT.TB’, ‘TB uveitis’, ‘serpiginous like choroiditis’, ‘tuberculoma’, ‘TB vasculitis’, ‘TB panuveiti

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Tabatneck, Mary, Jeffrey Campbell, Mingwei Sun, et al. "655. Patterns of Interferon-Gamma Release Assay (IGRA) Testing for Tuberculosis in Patients Less Than 2 Years Old." Open Forum Infectious Diseases 8, Supplement_1 (2021): S429—S430. http://dx.doi.org/10.1093/ofid/ofab466.852.

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Abstract Background The American Academy of Pediatrics recommends use of Interferon-Gamma Release Assays (IGRAs) to diagnose tuberculosis (TB) infection in patients ≥2 years old. However, IGRAs are not currently recommended in younger patients due to limited data and concerns of invalid/indeterminate test results, which occur if there is a positive or negative control failure. We sought to characterize the patterns of IGRA use in clinical practice and results of IGRAs in patients &lt; 2 years old. Methods We conducted a retrospective cohort study of children &lt; 2 years old at two lar

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Thomason, Jenna L., Uchechukwu M. Obih, David M. Koelle, Christian Lood, and and Grant Hughes. "An interferon-gamma release assay as a novel biomarker in systemic lupus erythematosus." Rheumatology 59, no. 11 (2020): 3479–87. http://dx.doi.org/10.1093/rheumatology/keaa161.

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Abstract Objective The mycobacterium tuberculosis (TB) IFN-γ release assay (TB-IGRA) assesses peripheral blood cell release of IFN-γ upon ex vivo exposure to mitogen (IGRA-MT), TB antigen or a negative/nil control (IGRA-NL); IGRA-NL is a measure of spontaneous IFN-γ release (SIR). Here, we investigate the diagnostic associations of elevated SIR and the potential use of IGRA-NL as a novel biomarker in SLE. Methods We analysed diagnostic code frequencies among 11 823 individuals undergoing TB-IGRA testing between 2010 and 2015 in a large urban US health-care system. To study the relationship bet

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Vassilopoulos, Dimitrios, Stamatoula Tsikrika, Chrisoula Hatzara, et al. "Comparison of Two Gamma Interferon Release Assays and Tuberculin Skin Testing for Tuberculosis Screening in a Cohort of Patients with Rheumatic Diseases Starting Anti-Tumor Necrosis Factor Therapy." Clinical and Vaccine Immunology 18, no. 12 (2011): 2102–8. http://dx.doi.org/10.1128/cvi.05299-11.

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ABSTRACTGamma interferon release assays (IGRAs) are increasingly used for latentMycobacterium tuberculosisinfection (LTBI) screening in patients with rheumatic diseases starting anti-tumor necrosis factor (anti-TNF) therapies. We compared the performances of two IGRAs, an enzyme-linked immunospot release assay (T-SPOT.TB) and an enzyme-linked immunosorbent assay (QuantiFERON-TB Gold In Tube [QFT-GIT]), to that of tuberculin skin testing (TST) for LTBI screening of 157 consecutive rheumatic patients starting anti-TNF therapies. Among 155 patients with valid results, 58 (37%) were positive by TS

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Kim, Keun Ju, Seong-Eun Ryu, Ha-Na Lee, Seung-Hwan Oh, and Chulhun L. Chang. "Evaluation of a New Chemiluminescent Immunoassay-Based Interferon-Gamma Release Assay for Detection of Latent Tuberculosis Infection." Medicina 59, no. 10 (2023): 1734. http://dx.doi.org/10.3390/medicina59101734.

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Background and Objectives: This study aimed to evaluate the performance of a new chemiluminescent immunoassay-based tuberculosis (TB) interferon-gamma release assay (IGRA), AdvanSureI3 TB-IGRA (LG Chem Ltd., Seoul, Republic of Korea), for detecting latent tuberculosis infection in comparison with T-SPOT.TB (Oxford Immunotec, Oxford, UK). Materials and Methods: Between June 2021 and December 2021, 125 non-duplicate blood specimens were collected from adult volunteers; each subject received both tests concurrently. Total agreement and Cohen’s kappa coefficient (κ) were used to calculate concorda

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Campbell, Jeffrey, Mingwei Sun, Wei He, et al. "646. Increasing Use of Interferon-Gamma Release Assay to Test for Pediatric Tuberculosis in a Low-Burden Setting." Open Forum Infectious Diseases 8, Supplement_1 (2021): S425. http://dx.doi.org/10.1093/ofid/ofab466.843.

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Abstract Background The American Academy of Pediatrics recommends tuberculin skin tests (TSTs) or interferon gamma release assays (IGRAs) to test for tuberculosis (TB) infection in children ≥2 years old, and prioritizes IGRA testing in Bacille Calmette-Guérin vaccine recipients due to cross-reactivity. TSTs require a return visit, which frequently results in loss to follow up. Growing evidence supports accuracy of IGRA testing in pediatric patients, including young children, leading to calls for preferential use of IGRA over TST. We sought to evaluate trends in IGRA use in children over time.

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Oliveira, Sandra Maria do Valle Leone de, Anete Trajman, Anamaria Mello Miranda Paniago, et al. "Frequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals." Jornal Brasileiro de Pneumologia 43, no. 3 (2017): 215–18. http://dx.doi.org/10.1590/s1806-37562016000000125.

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ABSTRACT Objective: To evaluate the frequency of and factors associated with indeterminate interferon-gamma release assay (IGRA) results in people living with HIV/AIDS (PLWHA). Methods: We tested 81 PLWHA in the central-west region of Brazil, using the tuberculin skin test and an IGRA. Information on sociodemographic and clinical variables was gathered through the use of questionnaires and from medical records. The association of those variables with indeterminate results was analyzed by calculating the adjusted ORs in a multivariate logistic regression model. Concordance was evaluated by dete

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Banaei, Niaz, Rajiv L. Gaur, and Madhukar Pai. "Interferon Gamma Release Assays for Latent Tuberculosis: What Are the Sources of Variability?" Journal of Clinical Microbiology 54, no. 4 (2016): 845–50. http://dx.doi.org/10.1128/jcm.02803-15.

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Interferon gamma release assays (IGRAs) are blood-based tests intended for diagnosis of latent tuberculosis infection (LTBI). IGRAs offer logistical advantages and are supposed to offer improved specificity over the tuberculin skin test (TST). However, recent serial testing studies of low-risk individuals have revealed higher false conversion rates with IGRAs than with TST. Reproducibility studies have identified various sources of variability that contribute to nonreproducible results. Sources of variability can be broadly classified as preanalytical, analytical, postanalytical, manufacturing

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Franken, Willeke P. J., Ben F. P. J. Koster, Ailko W. J. Bossink, et al. "Follow-Up Study of Tuberculosis-Exposed Supermarket Customers with Negative Tuberculin Skin Test Results in Association with Positive Gamma Interferon Release Assay Results." Clinical and Vaccine Immunology 14, no. 9 (2007): 1239–41. http://dx.doi.org/10.1128/cvi.00185-07.

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ABSTRACT We report a follow-up study of 29 subjects with negative tuberculin skin test (TST) results in association with positive gamma interferon release assay (IGRA) results, mainly due to responses to CFP-10 in the T-SPOT.TB assay, during a contact investigation. One year later, 12/29 subjects (41%) had converted to positive TST results in association with negative IGRA results.

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Jurčev-Savičević, Anamarija, Vera Katalinić-Janković, Kornelija Miše, and Ivan Gudelj. "The Role of Interferon-gamma Release Assay in Tuberculosis Control." Archives of Industrial Hygiene and Toxicology 63, no. 1 (2012): 49–59. http://dx.doi.org/10.2478/10004-1254-63-2012-2134.

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The Role of Interferon-gamma Release Assay in Tuberculosis ControlTuberculosis is still one of the major global public health threats. Countries with low incidence must focus on exhausting the reservoir of future cases by preventing reactivation. Therefore, it is important to identify and effectively treat those individuals who have latent tuberculosis infection and who may develop active disease. The tuberculin skin test has been the standard for detection of immune response against M. tuberculosis since the beginning of the 20th century. The new millennium has brought advancement in the diag

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Detjen, A. K., L. Loebenberg, H. M. S. Grewal, et al. "Short-Term Reproducibility of a Commercial Interferon Gamma Release Assay." Clinical and Vaccine Immunology 16, no. 8 (2009): 1170–75. http://dx.doi.org/10.1128/cvi.00168-09.

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ABSTRACT Interferon gamma release assays (IGRAs) have been shown to be sensitive and highly specific for the detection of immune memory against Mycobacterium tuberculosis. Little is known about the reproducibility and within-person variability of these assays. Various aspects of short-term reproducibility of a commercial IGRA, the QuantiFERON-TB Gold In-Tube (QFT-IT) assay, were assessed. The QFT-IT assay was performed twice within 3 days in 27 health care workers in Cape Town, South Africa. Two sets of tests were performed by different operators on day 1, and one set was performed on day 3. A

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Nemes, Elisa, Deborah Abrahams, Thomas J. Scriba, et al. "Diagnostic Accuracy of Early Secretory Antigenic Target-6–Free Interferon-gamma Release Assay Compared to QuantiFERON-TB Gold In-tube." Clinical Infectious Diseases 69, no. 10 (2019): 1724–30. http://dx.doi.org/10.1093/cid/ciz034.

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Abstract Background Early secretory antigenic target-6 (ESAT-6) is an immunodominant Mycobacterium tuberculosis (M.tb) antigen included in novel vaccines against tuberculosis (TB) and in interferon-gamma (IFN-γ) release assays (IGRAs). Therefore, the availability of an ESAT-6–free IGRA is essential to determine M.tb infection status following vaccination with ESAT-6–containing vaccines. We aimed to qualify a recently developed ESAT-6–free IGRA and to assess its diagnostic performance in comparison to QuantiFERON-TB Gold In-tube (QFT). Methods Participants with different levels of M.tb exposure

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Sandhu, Preeti, Chris Taylor, Robert F. Miller, and Frank A. Post. "Implementation of routine interferon-gamma release assay testing in a South London HIV cohort." International Journal of STD & AIDS 31, no. 3 (2020): 264–67. http://dx.doi.org/10.1177/0956462419893536.

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Human immunodeficiency virus (HIV) infection is a major risk factor for the development of tuberculosis (TB). Although guidelines recommend that people with HIV from high TB incidence countries and those with risk factors are screened for latent TB infection (LTBI) using interferon-gamma release assays (IGRAs), this has not been widely implemented in the UK. We introduced universal LTBI screening using IGRAs at nurse-led induction clinics for patients newly presenting, transferring or re-presenting for HIV care and conducted a prospective audit from 1 January 2018 to 30 June 2019 to identify o

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Rhamdan, Daffa Muhammad, Anita Liliana Susanti, and Siska Telly Pratiwi. "PROFIL INTERFERON-GAMMA RELEASE ASSAY UNTUK DETEKSI TUBERKULOSIS LATEN PADA KARYAWAN UNIVERSITAS JENDERAL ACHMAD YANI." Medika Kartika Jurnal Kedokteran dan Kesehatan, Volume 8 No 2 (June 30, 2025): 141–51. https://doi.org/10.35990/mk.v8n2.p141-151.

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Pekerja di institusi pendidikan memiliki risiko terpapar Mycobacterium tuberculosis melalui interaksi sehari-hari di lingkungan akademik yang padat dan kontak dengan banyak individu dari latar belakang dan domisili yang beragam. Indonesia merupakan negara dengan beban TB tinggi, mengingat tingginya prevalensi TB di masyarakat umum maka risiko semakin relevan. Penelitian ini bertujuan untuk menilai angka kejadian Latent Tuberculosis Infection (LTBI) di kalangan karyawan universitas menggunakan pemeriksaan Interferon-Gamma Release Assay (IGRA). Penelitian potong lintang dilakukan pada 35 karyawa

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Jonnalagadda, Sasi R., Elizabeth Brown, Barbara Lohman-Payne, et al. "Consistency ofMycobacterium tuberculosis-Specific Interferon-Gamma Responses in HIV-1-Infected Women during Pregnancy and Postpartum." Infectious Diseases in Obstetrics and Gynecology 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/950650.

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Background. We determined the consistency of positive interferon-gamma (IFN-γ) release assays (IGRAs) to detect latent TB infection (LTBI) over one-year postpartum in HIV-1-infected women.Methods. Women with positive IGRAs during pregnancy had four 3-monthly postpartum IGRAs. Postpartum change in magnitude of IFN-γ response was determined using linear mixed models.Results. Among 18 women with positive pregnancy IGRA, 15 (83%) had a subsequent positive IGRA; 9 (50%) were always positive, 3 (17%) were always negative, and 6 (33%) fluctuated between positive and negative IGRAs. Women with pregnan

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Ren, Chunnian, Jie Tang, and Liangfeng Xia. "Interferon gamma release assays for diagnosis of osteoarticular tuberculosis: A systematic review and meta-analysis." PLOS ONE 17, no. 6 (2022): e0269234. http://dx.doi.org/10.1371/journal.pone.0269234.

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Background Although the Interferon Gamma Release Assays (IGRA) is often used to identify latent tuberculosis, it also plays a crucial role in diagnosing active extrapulmonary tuberculosis. Some studies have assessed the use of IGRA as a biomarker for osteoarticular tuberculosis (OATB), which is elevated following TB infection. Still, conclusive results about its effectiveness have not been reported. Method We searched PubMed, Embase, and Cochran databases. We obtained literature related to the diagnosis of OATB by IGRA, and the retrieval period was from the establishment of the database to Jun

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Dewi, Juliani. "Perkembangan Pemeriksaan Interferon-Gamma Release Assay (IGRA) dengan Metode T-SPOT.TB serta Aspek Klinis Pelaporan Hasil." MEDICINUS 33, no. 1 (2020): 33–42. http://dx.doi.org/10.56951/medicinus.v33i1.5.

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Screening dan pengobatan latent tuberculosis infection (LTBI) memainkan peranan penting dalam mengontrol tuberculosis (TB). Centers for Disease Prevention and Control (CDC) mengingatkan adanya risiko transmisi TB bagi para petugas kesehatan dan menganjurkan setiap pelayanan kesehatan memiliki program kontrol infeksi TB. CDC merekomendasikan penggunaan pemeriksaan Interferon-Gamma Release Assay (IGRAs) pada orang yang memiliki riwayat kontak dengan penderita atypical mycobacteria, pemeriksaan selama kehamilan, screening petugas kesehatan, serta evaluasi serial infeksi Mycobacterium tuberculosis

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Kang, S. J. W., G. W. Eather, F. Qureshi, and J. R. Scott. "Predictors of interferon-gamma release assay results and their association with COVID-19 infection outcomes." IJTLD OPEN 1, no. 10 (2024): 443–48. http://dx.doi.org/10.5588/ijtldopen.24.0180.

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<sec><title>BACKGROUND</title>An ‘indeterminate’ interferon-gamma release assay (IGRA) result used in the diagnosis of latent TB infection (LTBI) is most commonly due to an inadequate control (or ‘mitogen’) response, which may reflect underlying T-cell dysfunction.</sec><sec><title>METHODS</title>We performed a single-centre, retrospective study on COVID-19 patients admitted to a tertiary referral hospital who had IGRA testing conducted over a 5-month period. The primary outcomes included predictors of indeterminate IGRA results and associations with C

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Stockbridge, Erica L., Abiah D. Loethen, Esther Annan, and Thaddeus L. Miller. "Interferon gamma release assay tests are associated with persistence and completion of latent tuberculosis infection treatment in the United States: Evidence from commercial insurance data." PLOS ONE 15, no. 12 (2020): e0243102. http://dx.doi.org/10.1371/journal.pone.0243102.

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Background Risk-targeted testing and treatment of latent tuberculosis infection (LTBI) is a critical component of the United States’ (US) tuberculosis (TB) elimination strategy, but relatively low treatment completion rates remain a challenge. Both treatment persistence and completion may be facilitated by diagnosing LTBI using interferon gamma release assays (IGRA) rather than tuberculin skin tests (TST). Methods We used a national sample of administrative claims data to explore associations diagnostic test choice (TST, IGRA, TST with subsequent IGRA) and treatment persistence and completion

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Nirav, Patel and Sowmya Nanjappa. "A Masquerading Case of IGRA Positive Mycobacterium Szulgai." Global Journal of Rare Diseases 2, no. 1 (2017): 009–10. https://doi.org/10.17352/gjrd.000007.

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It is well known that Interferon-gamma release assays (IGRAs) are more specific than the purified protein derivative (PPD) skin tests in diagnosing tuberculosis as it is not confounded by prior bacillus Calmette-Guérin (BCG) vaccination. We present a unique case of false positive IGRA in a 57 year old female with Mycobacterium szulgai cavitary lung infection.

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Wyndham-Thomas, Chloé, Véronique Corbière, Violette Dirix, et al. "Key Role of Effector Memory CD4+T Lymphocytes in a Short-Incubation Heparin-Binding Hemagglutinin Gamma Interferon Release Assay for the Detection of Latent Tuberculosis." Clinical and Vaccine Immunology 21, no. 3 (2014): 321–28. http://dx.doi.org/10.1128/cvi.00651-13.

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ABSTRACTThe treatment of latent tuberculosis infection (LTBI) in target populations is one of the current WHO strategies for preventing active tuberculosis (TB) infection and reducing theMycobacterium tuberculosisreservoir. Therefore, powerful LTBI screening tools are indispensable. A gamma interferon release assay (IGRA) in response to the stimulation of peripheral blood mononuclear cells by the latency antigen native heparin-binding hemagglutinin (nHBHA-IGRA) has proven its potential for this purpose. We have evaluated its possible optimization through a reduction of incubation time from 96

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Mitchell, Jordan L., Conor O’Halloran, Paul Stanley, et al. "Serial Interferon-Gamma Release Assay (IGRA) Testing to Monitor Treatment Responses in Cases of Feline Mycobacteriosis." Pathogens 10, no. 6 (2021): 657. http://dx.doi.org/10.3390/pathogens10060657.

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The interferon-gamma release assay (IGRA) is used to diagnose cases of feline mycobacteriosis, but the use of serial testing to monitor treatment responses has not been evaluated in this species. From a population of cats that underwent IGRA testing for diagnostic investigation, individuals were identified with a pre- and end-of-treatment IGRA that passed control thresholds. The number of cats which reverted to negative at the end-of-treatment IGRA, changes in paired antigen-specific optical density (OD) values and differences in the pre-treatment antigen-specific OD values for those which und

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Grant, J., J. Jastrzebski, J. Johnston, et al. "Interferon-Gamma Release Assays Are a Better Tuberculosis Screening Test for Hemodialysis Patients: A Study and Review of the Literature." Canadian Journal of Infectious Diseases and Medical Microbiology 23, no. 3 (2012): 114–16. http://dx.doi.org/10.1155/2012/287181.

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Diagnosing latent tuberculosis (TB) infection (LTBI) in dialysis patients is complicated by poor response to tuberculin skin testing (TST), but the role of interferon-gamma release assays (IGRAs) in the dialysis population remains uncertain. Seventy-nine patients were recruited to compare conventional diagnosis (CD) with the results of two IGRA tests in a dialysis unit. Combining TST, chest x-ray and screening questionnaire results (ie, CD) identified 24 patients as possible LTBI. IGRA testing identified 22 (QuantiFERON Gold IT, Cellestis, USA) and 23 (T-spot.TB, Oxford Immunotec, United Kingd

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Monica Puspa Sari. "Interferon Gamma sebagai Deteksi Awal Infeksi yang Disebabkan oleh Toxoplasma gondii." Jurnal MedScientiae 1, no. 1 (2022): 85–89. http://dx.doi.org/10.36452/jmedscie.v1i1.2572.

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Diagnosis dini infeksi Toxoplasma gondii penting untuk efektifitas pengobatan. Obat yang tersedia tidak dapat membunuh bradizoit yang terkandung dalam kista, obat tersebut hanya dapat membunuh pada stadium takizoit. Semakin cepat infeksi T.gondii terdeteksi maka semakin besar kemungkinan infeksi dapat dihentikan dan keberhasilan pengobatan tercapai. Saat ini tes serologi berbasis antibodi menjadi metode diagnostik yang paling sering digunakan untuk mendeteksi T. gondii. Namun, tes serologi diketahui memiliki beberapa keterbatasan. Berdasarkan penelitian terakhir, Interferon-gamma release assay

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KOWADA, A. "Cost-effectiveness of interferon-gamma release assay for entry tuberculosis screening in prisons." Epidemiology and Infection 141, no. 10 (2013): 2224–34. http://dx.doi.org/10.1017/s0950268812002907.

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SUMMARYThe incidence of active tuberculosis (TB) and latent tuberculosis infection (LTBI) in inmates and prison staff is higher than that in the general population. Mycobacterium tuberculosis-specific interferon-gamma release assays (IGRAs) provide more accurate diagnosis of M. tuberculosis infection with higher specificity than the tuberculin skin test (TST). To assess the cost-effectiveness of QuantiFERON®-TB Gold In-Tube (QFT) compared to TST, TST followed by QFT and chest X-ray, we constructed Markov models using a societal perspective on the lifetime horizon. The main outcome measure of e

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Taki-Eddin, Lynn, and Fawza Monem. "Utility of an interferon-gamma release assay as a potential diagnostic aid for active pulmonary tuberculosis." Journal of Infection in Developing Countries 6, no. 01 (2011): 67–72. http://dx.doi.org/10.3855/jidc.2098.

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Introduction: Sensitivity, specificity, early confirmation and obtaining an optimal specimen are challenging problems in active tuberculosis (TB) diagnosis. Interferon-gamma release assay (IGRA) is a good indicator for latent TB but can it be useful as a diagnostic tool for active TB? This study was designed to address these challenges and assess the potential of IGRA as a diagnostic indicator of active pulmonary TB by comparing it with other MT diagnostic conventional methods and molecular methods.Methodology: The study was conducted on 91 patients with suspicion of pulmonary active TB. Quant

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Vesenbeckh, Silvan M., Nicolas Schönfeld, Harald Mauch, et al. "The Use of Interferon Gamma Release Assays in the Diagnosis of Active Tuberculosis." Tuberculosis Research and Treatment 2012 (2012): 1–4. http://dx.doi.org/10.1155/2012/768723.

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Interferon gamma release assays (IGRAs) arein vitroimmunologic diagnostic tests used to identifyMycobacterium tuberculosisinfection. They cannot differentiate between latent and active infections. The cutoff suggested by the manufacturer is 0.35 IU/mL for latent tuberculosis. As IGRA tests were recently approved for the differential diagnosis of active tuberculosis, we assessed the diagnostic accuracy of the latest generation IGRA for detection of active tuberculosis in a low-incidence area in Germany. Our consecutive case series includes 61 HIV negative,Mycobacterium tuberculosisculture posit

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Alrajhi, Saad, Pascale Germain, Myriam Martel, et al. "Concordance between tuberculin skin test and interferon-gamma release assay for latent tuberculosis screening in inflammatory bowel disease." Intestinal Research 18, no. 3 (2020): 306–14. http://dx.doi.org/10.5217/ir.2019.00116.

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Background/Aims: Latent tuberculosis screening is mandatory prior to initiating anti-tumor necrosis factor (anti-TNF) medications. Guidelines recommend interferon-gamma release assays (IGRA) as first line screening method for the general population. Studies provided conflicting evidence on IGRA and tuberculin skin test (TST) performance in inflammatory bowel disease (IBD) patients. We assessed test concordance and the effects of immunosuppression on their performance in IBD patients.Methods: We searched MEDLINE, Embase and Cochrane databases (2011–2018) for studies testing TST and IGRA in IBD.

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Gutierrez, Jesús, Mary Nsereko, LaShaunda L. Malone, et al. "Capturing Recent Mycobacterium tuberculosis Infection by Tuberculin Skin Test vs. Interferon-Gamma Release Assay." Tropical Medicine and Infectious Disease 9, no. 4 (2024): 81. http://dx.doi.org/10.3390/tropicalmed9040081.

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Reductions in tuberculosis (TB) incidence require identification of individuals at high risk of developing active disease, such as those with recent Mycobacterium tuberculosis (Mtb) infection. Using a prospective household contact (HHC) study in Kampala, Uganda, we diagnosed new Mtb infection using both the tuberculin skin test (TST) and interferon-gamma release assay (IGRA). Our study aimed to determine if the TST adds additional value to the characterization of IGRA converters. We identified 13 HHCs who only converted the IGRA (QFT-only converters), 39 HHCs who only converted their TST (TST-

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Jung, Jaewan, Byung Woo Jhun, Mijeong Jeong, et al. "Is the New Interferon-Gamma Releasing Assay Beneficial for the Diagnosis of Latent and Active Mycobacterium tuberculosis Infections in Tertiary Care Setting?" Journal of Clinical Medicine 10, no. 7 (2021): 1376. http://dx.doi.org/10.3390/jcm10071376.

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Interferon-Gamma Release Assays (IGRAs) are widely used in the laboratory diagnosis of Mycobacterium tuberculosis (MTB) infections, particularly in the latent form. We compared the performance of a newly developed IGRA, the Standard E TB-Feron ELISA (TBF) with the currently used QuantiFERON-TB Gold Plus assay (QFT-Plus) for the detection of latent tuberculosis infections (LTBIs) in tertiary care settings. We also investigated interferon-gamma (IFN-γ) released by T cell subsets via intracellular cytokine staining (ICS) and flow cytometry. A total of 335 subjects including 40 patients with activ

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Moyo, Nompilo, James Trauer, Peter Trevan, et al. "Tuberculosis screening in an aged care residential facility in a low-incidence setting." Communicable Diseases Intelligence 41 (September 1, 2017): 209–11. https://doi.org/10.33321/cdi.2017.41.30.

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This is a retrospective cohort study of tuberculosis contact tracing and screening in an elderly residential facility in Victoria. In the absence of specific guidelines regarding an optimal test for this population, 18 residents were tested with both tuberculin skin test (TST) and interferon-gamma release assay (IGRA), and all underwent symptom assessment and chest x-ray (CXR).

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Miyake, Satoshi, Masayuki Endo, Keiko Ikedo, Aya Kayebeta, Ikumi Takahashi, and Masaki Ota. "Positivity of Interferon-Gamma Release Assay among Foreign-Born Individuals, Tokyo, Japan, 2015–2017." International Journal of Mycobacteriology 9, no. 1 (2020): 53–57. http://dx.doi.org/10.4103/ijmy.ijmy_177_19.

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Background: The aim of this study is to analyze interferon-gamma release assay (IGRA) data of foreign-born individuals in Japan derived from tuberculosis (TB) contact investigations. Methods: A contact with a TB patient was considered to have occurred when an individual had contact with a TB patient for more than 8 h indoors. This is a retrospective cohort study, and all the TB contacts tested with IGRA during the contact investigations conducted by the Shinjuku city Health Office from 2015 through 2017 were enrolled. Results: A total of 880 foreign-born contacts were investigated. The IGRA po

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Agostinis, A., C. Heffernan, R. Long, A. Beckon, S. Cockburn, and R. Ahmed. "Interferon-gamma release assays for latent tuberculosis infection screening in Canadian federal correctional facilities." International Journal of Tuberculosis and Lung Disease 25, no. 6 (2021): 447–52. http://dx.doi.org/10.5588/ijtld.20.0801.

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BACKGROUND: The correctional setting presents an opportunity for latent TB infection (LTBI) screening in an otherwise difficult to reach demographic. We evaluate factors associated with the fidelity of the tuberculin skin test (TST) and interferon-gamma release assay (IGRA), specifically the QuantiFERON®-TB Gold In-Tube assay (QFT-GIT), explain factors associated with discordance, and report LTBI treatment outcomes.METHODS: We describe the association between demographic and clinical variables, and predictors of concordance with IGRA using univariate logistic regression in a population of TST-

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Clarke, Charlene, Netanya Bernitz, Wynand J. Goosen, and Michele A. Miller. "High-Specificity Test Algorithm for Bovine Tuberculosis Diagnosis in African Buffalo (Syncerus caffer) Herds." Pathogens 11, no. 12 (2022): 1393. http://dx.doi.org/10.3390/pathogens11121393.

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Ante-mortem bovine tuberculosis (bTB) tests for buffaloes include the single comparative intradermal tuberculin test (SCITT), interferon-gamma (IFN-γ) release assay (IGRA) and IFN-γ-inducible protein 10 release assay (IPRA). Although parallel test interpretation increases the detection of Mycobacterium bovis (M. bovis)-infected buffaloes, these algorithms may not be suitable for screening buffaloes in historically bTB-free herds. In this study, the specificities of three assays were determined using M. bovis-unexposed herds, historically negative, and a high-specificity diagnostic algorithm wa

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Meriyanti, Tandry, Maroloan Aruan, Diana Intan Lusiana Gabriella, and Justina Andrea Renjaan. "Comparison of Lateral-flow Nanoparticle Fluorescence Assay and ELISA Method for Interferon-y Release Assay Test." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 30, no. 3 (2024): 265–68. http://dx.doi.org/10.24293/ijcpml.v30i3.2212.

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The detection of latent tuberculosis (TB) infection to prevent progression to active TB disease is an essential part of the WHO's end-TB strategy. Diagnosis of latent TB infection is based on detecting immune responses to Mycobacterium tuberculosis antigens. Interferon Gamma Release Assays (IGRA) are superior to Tuberculin Skin Tests (TST) for detecting latent infection; however, the performance of IGRA is limited in resource-limited settings. This study evaluated the sensitivity, specificity, and agreement of the lateral-flow nanoparticle fluorescence assay (QIAreach QFT) compared with the EL

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Ambar, Nabil Salim, Aryati Aryati, Tutik Kusmiati, and Erwin Astha Triyono. "CORRELATION BETWEEN INTERFERON GAMMA RELEASE ASSAY OF ELISPOT METHOD AND CD4+ T LYMPHOCYTE CELL COUNT IN HIV POSITIVE PATIENTS." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 25, no. 3 (2019): 333. http://dx.doi.org/10.24293/ijcpml.v25i3.1416.

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Introduction. HIV is a virus that can cause AIDS, which affects the immune system and weakens the body function in fighting disease. The primary cells that HIV attacks are CD4+ T lymphocytes. Opportunistic Infections (OIs) are the biggest risk factors of death in HIV patients and occur in CD4+ T cells <200 cells/μL lymphocytes. TB is a disease with a high mortality rate in the world where Indonesia is a TB endemic country with the highest morbidity rates of TB in the world. The most common OI in people with HIV is TB. The number of limitations on Tuberculin Skin Test (TST) is large, thus in

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Kurti, Zsuzsanna, Barbara Dorottya Lovasz, Krisztina Barbara Gecse, et al. "Tuberculin Skin Test and Quantiferon in BCG Vaccinated, Immunosuppressed Patients with Moderate-to-Severe Inflammatory Bowel Disease." Journal of Gastrointestinal and Liver Diseases 24, no. 4 (2015): 467–72. http://dx.doi.org/10.15403/jgld.2014.1121.244.bcg.

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Background & Aims: There are few data available on the effect of immunomodulator/biological therapy on the accuracy of the tuberculin skin test (TST) and interferon-gamma release assay (IGRA) in BCG-vaccinated immunosuppressed patients with inflammatory bowel disease (IBD). Our aim was to define the accuracy, predictors and agreement of TST and IGRA in a BCG-vaccinated immunosuppressed referral IBD cohort. Methods: 166 consecutive moderate-to-severe IBD patients (122 Crohn’s disease, CD and 44 ulcerative colitis, UC) were enrolled in a prospective study from three centers. Patients w

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Feng, Yu, Liangquan Zhu, Xiaowei Peng та ін. "Development of an interferon-γ release assay (IGRA) for detection of Brucella abortus and clinical diagnosis of brucellosis". Journal of Infection in Developing Countries 11, № 11 (2017): 847–53. http://dx.doi.org/10.3855/jidc.9265.

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Introduction: Brucellosis, caused by Brucella abortus (B. abortus), is an important zoonosis posing a great risk to both livestock and humans. Currently, most assays for clinical diagnosis of brucellosis have been developed based on serological principles; however, these assays have a number of limitations and disadvantages. Methodology: To address this concern, the aim of this study was to develop a gamma interferon (IFN-γ) release assay (IGRA) for the diagnosis of brucellosis. Towards this end, the stimulating effect induced by different somatic antigens of B. abortus on the secretion

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Juliani Dewi. "<b>Perbandingan Uji TB IGRA Menggunakan Metode T-SPOT.TB dan CLIA</b>." MEDICINUS 37, no. 3 (2024): 22–26. http://dx.doi.org/10.56951/n2hdkv05.

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Diagnosis tuberkulosis laten (latent tuberculosis infection/LTBI) merupakan kunci penting dalam pengendalian kejadian tuberkulosis (TB). Uji interferon gamma release assay (IGRA) umumnya digunakan untuk mendeteksi interferon gamma (IFN-γ) sebagai penanda LTBI, dengan metode seperti T-SPOT.TB yang telah diimplementasikan secara luas. Akhir-akhir ini, metode chemiluminescent immunoassay (CLIA) dengan analyzer yang sepenuhnya otomatis, juga telah digunakan untuk deteksi dan kuantifikasi IFN-γ. Penelitian ini bertujuan untuk membandingkan antara kedua metode tersebut. Dua puluh sampel darah hepari

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Osakabe, Yuki, Fumihiro Yamaguchi, Ayako Suzuki, et al. "In-hospital blood collection increases the rate of indeterminate results in interferon-gamma release assays." Therapeutic Advances in Respiratory Disease 16 (January 2022): 175346662210778. http://dx.doi.org/10.1177/17534666221077817.

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Background: The interferon (IFN)-γ release assay (IGRA) has recently been established as a method to evaluate the infection status of tuberculosis instead of the tuberculin skin test. However, indeterminate results can create challenges to interpretation. The IGRA has been available in Japan since 2005, including the recently launched QuantiFERON-TB Gold Plus (QFT-plus) assay. Objectives: The aim of this study was to investigate the clinical features and predictors of indeterminate results by the QFT-plus test in routine practice. Methods: This was a cross-sectional study of 1258 patients. Mul

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Aggarwal, Ashutosh N., Ritesh Agarwal, Dheeraj Gupta, Sahajal Dhooria, and Digambar Behera. "Interferon Gamma Release Assays for Diagnosis of Pleural Tuberculosis: a Systematic Review and Meta-Analysis." Journal of Clinical Microbiology 53, no. 8 (2015): 2451–59. http://dx.doi.org/10.1128/jcm.00823-15.

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The role of interferon gamma release assays (IGRAs), although established for identifying latent tuberculosis, is still evolving in the diagnosis of active extrapulmonary tuberculosis. We systematically evaluated the diagnostic performance of blood- and pleural fluid-based IGRAs in tuberculous pleural effusion (TPE). We searched the PubMed and Embase databases for studies evaluating the use of commercially available IGRAs on blood and/or pleural fluid samples for diagnosing TPE. The quality of the studies included was assessed through the QUADAS-2 tool. The pooled estimates of sensitivity and

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Ramos, Angélica, Sandra Martins, Ana Sofia Marinho, Pedro Norton, Maria João Cardoso, and João Tiago Guimarães. "Evaluation of SARS-CoV-2 interferon gamma release assay in BNT162b2 vaccinated healthcare workers." PLOS ONE 19, no. 5 (2024): e0303244. http://dx.doi.org/10.1371/journal.pone.0303244.

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To predict protective immunity to SARS-CoV-2, cellular immunity seems to be more sensitive than humoral immunity. Through an Interferon-Gamma (IFN-γ) Release Assay (IGRA), we show that, despite a marked decrease in total antibodies, 94.3% of 123 healthcare workers have a positive cellular response 6 months after inoculation with the 2nd dose of BNT162b2 vaccine. Despite the qualitative relationship found, we did not observe a quantitative correlation between IFN-γ and IgG levels against SARS-CoV-2. Using stimulated whole blood from a subset of participants, we confirmed the specific T-cell res

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Ntshiqa, Thobani, Kavindhran Velen, Sibuse Ginindza, et al. "Resistance to tuberculin skin test/interferon-gamma release assay conversion among highly TB exposed, HIV infected goldminers in South Africa." PLOS One 20, no. 5 (2025): e0318819. https://doi.org/10.1371/journal.pone.0318819.

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Background A small proportion of goldminers in South Africa resist tuberculin skin test (TST)/interferon-gamma release assay (IGRA) conversion despite high rates of HIV and prolonged exposure to TB. We conducted a study among HIV-infected goldminers to determine the: i) proportion who resisted TST/IGRA conversion and ii) epidemiological factors associated with resistance to TST/IGRA conversion. Methods We enrolled HIV-infected goldminers who were on antiretroviral treatment, aged 33–60 years, with ≥15 years’ service, no prior or current TB, no silicosis, and with body mass index >18.5 kg/m2

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Mayito, Jonathan, Adrian R. Martineau, Divya Tiwari, et al. "Determinants of QuantiFERON Plus-diagnosed tuberculosis infection in adult Ugandan TB contacts: A cross-sectional study." PLOS ONE 18, no. 3 (2023): e0281559. http://dx.doi.org/10.1371/journal.pone.0281559.

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Background The tuberculin skin test is commonly used to diagnose latent tuberculosis infection (LTBI) in resource-limited settings, but its specificity is limited by factors including cross-reactivity with BCG vaccine and environmental mycobacteria. Interferon-gamma release assays (IGRA) overcome this problem by detecting M. tuberculosis complex-specific responses, but studies to determine risk factors for IGRA-positivity in high TB burden settings are lacking. Methods We conducted a cross-sectional study to determine factors associated with a positive IGRA by employing the QuantiFERON-TB® Gol

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Tsai, Ming-Jui, Aristine Cheng, Hsin-Yun Sun, et al. "1390. A Novel Application of the Interferon-Gamma Release Assay (IGRA) Among End-Stage Heart Failure Patients Awaiting Heart Transplantation." Open Forum Infectious Diseases 6, Supplement_2 (2019): S505. http://dx.doi.org/10.1093/ofid/ofz360.1254.

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Abstract Background The optimal approach to assay the immune status in heart failure is challenging because of the inherent complexity of chronic inflammation. Interferon-gamma release assays (IGRAs) measure an aspect of cell-mediated immunity encompassing both the innate and adaptive immunity. In this study, we evaluated the utility of a commercial IGRA for predicting mortality and infectious complications among heart transplant candidates. Methods This prospective cohort study was conducted between August 1, 2014 and January 31, 2019 at a medical center in Taiwan. All heart transplant candid

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LEE, S. H., J. J. YIM, H. J. KIM, et al. "Adverse events and development of tuberculosis after 4 months of rifampicin prophylaxis in a tuberculosis outbreak." Epidemiology and Infection 140, no. 6 (2011): 1028–35. http://dx.doi.org/10.1017/s0950268811001476.

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SUMMARYWe screened tuberculosis (TB) contacts as an outbreak investigation with tuberculin skin test (TST) and interferon-gamma release assay (IGRA). We evaluated adverse events and TB incidence in all persons screened after rifampicin (RFP) prophylaxis, and specifically assessed the new TB cases in relation to initial TST and IGRA results. The 180 contacts were divided into four groups: TST+/IGRA+ (n=101), TST+/IGRA− (n=22), TST−/IGRA+ (n=16), and TST–/IGRA– (n=41). RFP treatment (4 months) was prescribed only to the TST+/IGRA+ group. Of 87 contacts who initiated prophylaxis, adverse events o

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Trauer, James M., Krispin M. Hajkowicz, Kevin G. Freeman та Vicki L. Krause. "Feasibility of latent tuberculosis infection diagnosis by interferon-γ release assay remote from testing facilities". Communicable Diseases Intelligence 35 (1 червня 2011): 168–71. https://doi.org/10.33321/cdi.2011.35.13.

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Although the tuberculin skin test (TST) has been the mainstay of the diagnosis of latent tuberculosis infection (LTBI) for many decades, interferon-gamma release assays (IGRAs) are gaining acceptance and are more specific for this diagnosis. The characteristics of one such IGRA, the QuantiFERON®-TB Gold Whole Blood In-Tube, make it feasible for use in a remote setting. This study performed 62 IGRAs with this test on individuals testing positive by TST, in a clinical setting over 3,000 km from the testing laboratory. Of these, 42 patients (68%) recorded negative results, 19 (31%) were positive,

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Abubakar, Ibrahim, Ajit Lalvani, Jo Southern, et al. "Two interferon gamma release assays for predicting active tuberculosis: the UK PREDICT TB prognostic test study." Health Technology Assessment 22, no. 56 (2018): 1–96. http://dx.doi.org/10.3310/hta22560.

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Background Despite a recent decline in the annual incidence of tuberculosis (TB) in the UK, rates remain higher than in most Western European countries. The detection and treatment of latent TB infection (LTBI) is an essential component of the UK TB control programme. Objectives To assess the prognostic value and cost-effectiveness of the current two interferon gamma release assays (IGRAs) compared with the standard tuberculin skin test (TST) for predicting active TB among untreated individuals at increased risk of TB: (1) contacts of active TB cases and (2) new entrants to the UK from high-TB

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de Medeiros, Vanessa Lucília Silveira, Fabiana Cristina Fulco Santos, Lílian Maria Lapa Montenegro, et al. "TST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patients." PLOS ONE 15, no. 12 (2020): e0242098. http://dx.doi.org/10.1371/journal.pone.0242098.

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Background Tuberculosis screening in psoriasis patients is complex due to the immunological alterations associated with psoriasis, the presence of comorbidities, and the effect of immunosuppressive treatment. However, it is not established whether the results of screening tests are affected by these factors in psoriasis patients. Objectives To determine whether there is a change in the results of the tuberculin skin test (TST) or the interferon-gamma release assay (IGRA) in psoriasis patients living in tuberculosis (TB)-endemic area after 12 weeks of methotrexate (MTX) treatment and to investi

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Vat, Sopharat, Marc Ghannoum, Pierre Laflamme, Mario Dugas, Manon Labrecque, and Valéry Lavergne. "Application and Interpretation of an Interferon-Gamma Release Assay: Results of an Audit in a Canadian Centre." Canadian Journal of Infectious Diseases and Medical Microbiology 23, no. 4 (2012): 183–86. http://dx.doi.org/10.1155/2012/838465.

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BACKGROUND: Interferon-gamma release assays (IGRAs) are newly approved for diagnosing latent tuberculosis infection (LTBI). An internal audit was conducted to review the use of a newly implemented IGRA at theHôpital du Sacré-Coeur de Montréal(Montréal, Québec) to evaluate its concordance with Canadian recommendations and its implication on diagnosis.METHODS: From April 2007 to January 2009, all Quantiferon TB Gold In-Tube (QFT, Cellestis inc, USA) tests performed in at theHôpital du Sacré-Coeur de Montréalwere retrieved. Strategies used to investigate LTBI and clinical interpretation of test r

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