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Dissertations / Theses on the topic 'Interferons (IFNs)'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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1

Liu, Qinfang. "Interaction of type I interferons and mTOR signaling underlying PRRSV infection." Thesis, Kansas State University, 2016. http://hdl.handle.net/2097/32860.

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Master of Science in Biomedical Sciences<br>Department of Anatomy and Physiology<br>Yongming Sang<br>Animal metabolic and immune systems integrate and inter-regulate to exert effective immune responses to distinct pathogens. The signaling pathway mediated by mechanistic target of rapamycin (mTOR) is critical in cellular metabolism and implicated in host antiviral responses. Recent studies highlight the significance of the mTOR signaling pathway in the interferon (IFN) response. Type I IFNs mediate host defense, particularly, against viral infections, and have myriad roles in antiviral innate a

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2

Sales, Paula Cristiane Motta. "Regulação da expressão da proteína cinase PKR na ausência de interferons (IFNs) e seu papel na resposta celular mediada por agonistas dos receptores TLR2 e TLR4." Universidade Federal de Minas Gerais, 2012. http://hdl.handle.net/1843/BUOS-9L7NEM.

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The role of protein kinase R (PKR) in the antiviral cell state induced by interferons (IFNs) is well known. The increase in its expression in response to stimulation by IFNs results in its autophosphorylation and phosphorylation of its substrate eIF2-alpha. This molecular event interferes with translation initiation of mRNA, which in turn results in inhibition of protein synthesis. Recent studies suggest the involvement of PKR in bacterial infections. However, how PKR is activated and what is its biological role in these infections is still largely unexplored. Thus, the central objective of ou

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3

Chen, Shu. "Studies on interferon (IFN) induction and isolation of IFN-inducing mutant viruses." Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/1678.

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The interferon (IFN) system is a powerful antiviral defense system. Host cell pattern recognition receptors (PRRs) recognise pathogen-associated molecule patterns (PAMPs) which when activated, lead to the transcription of the IFN-β gene. As a consequence IFN is secreted from the cell and activates the JAK-STAT pathway to up-regulate the transcription of IFN-stimulated genes (ISGs). The products of many ISGs inhibit viral replication and cell proliferation. Viruses encode IFN antagonists that dampen down the IFN response, making it less effective. However, within a virus population, there are a

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4

Walker, Angela Marie Roberts R. M. "The type I IFN of Bos taurus." Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/6864.

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The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on April 1, 2010). Vita. Thesis advisor: R. Michaels Roberts. "May 2008" Includes bibliographical references

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5

Esteve-Solé, Ana. "Primary and secondary immunodeficiencies of the IL-12/IFN-γ axis". Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/663924.

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IL-12/IFN-γ axis is a principal pathway for intramacrophagic pathogens immunity such as leishmania or mycobacteria. Alterations in this axis, being both congenic (causing the primary immunodeficiency Mendelian Susceptibility to Mycobacterial Disease, MSMD) or acquired (treatment with anti-TNF-α drugs) cause susceptibility to this type of microbes. MSMD causes susceptibility mainly to non-pathogenic mycobacteria, salmonella and candida; besides, MSMD- causing mutations have been detected in Mycobacterium tuberculosis and Leishmania patients. On the other hand, the death of an anti-TNF-α in-uter

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6

Killip, Marian J. "RNA virus modulation of IFN, PI3K and apoptosis." Thesis, St Andrews, 2009. http://hdl.handle.net/10023/777.

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7

Silva, Cláudia Maria de Melo. "Polimorfismos genéticos e associação com a produção de Interferon gama (IFN-y) em pacientes com Tuberculose pulmonar." Universidade Federal do Amazonas, 2014. http://tede.ufam.edu.br/handle/tede/2580.

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Made available in DSpace on 2015-04-11T13:54:31Z (GMT). No. of bitstreams: 1 Claudia Maria de Melo Silva.pdf: 2215806 bytes, checksum: c9afeecd5c357af061e1b38a8a31df56 (MD5) Previous issue date: 2014-04-28<br>FAPEAM - Fundação de Amparo à Pesquisa do Estado do Amazonas<br>Tuberculosis (TB) is a chronic infection caused by Mycobacterium tuberculosis complex and remains a major worldwide public health problem, leading to almost 1.45 million deaths annually. The state of Amazonas has a high rate incidence of TB, about 68.3/100,000 inhabitants in 2012. Only 5 to 10% of infected individuals dev

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8

Zurney, Jennifer Michelle. "Cardiac Cell Type-Specific Differences in the Interferon (IFN) Response, and Reovirus Repression of IFN." NCSU, 2008. http://www.lib.ncsu.edu/theses/available/etd-06302008-141954/.

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Viral myocarditis is an important human disease associated with a wide variety of viruses. The cardiac damage and inflammation associated with viral myocarditis can be immune mediated and/or due to direct cytopathic effect. Reovirus-induced myocarditis reflects direct virus-mediated apoptosis of cardiac cells, providing an excellent model to study direct cytopathic effect in the heart. Previous work has found interferon-beta (IFN) to be an important determinant for protection against viral myocarditis. Importantly, IFN signals through the Jak-STAT pathway to induce the expression of interferon

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9

SANTOS, Joelma Carvalho. "Análise de polimorfismos de único nucleotíldeo (SNP) e expressão dos genes das citocinas IFN-a1, IFN-y e do receptor IFN-a r1 em relação à quantificação da carga viral em pacientes com hepatite B." Universidade Federal de Pernambuco, 2014. https://repositorio.ufpe.br/handle/123456789/11489.

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Submitted by Marcelo Andrade Silva (marcelo.andradesilva@ufpe.br) on 2015-03-09T14:28:37Z No. of bitstreams: 2 DISSERTAÇÃO Joelma Carvalho Santos.pdf: 2064030 bytes, checksum: 9d9c233bec668a94294f6d19471cb844 (MD5) license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5)<br>Made available in DSpace on 2015-03-09T14:28:37Z (GMT). No. of bitstreams: 2 DISSERTAÇÃO Joelma Carvalho Santos.pdf: 2064030 bytes, checksum: 9d9c233bec668a94294f6d19471cb844 (MD5) license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Previous issue date: 2014<br>A presença de po

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Wang, Ling, and Shunbin Ning. ""Toll-Free" Pathways for Production of Type I Interferons." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/6540.

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Pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) are recognized by different cellular pathogen recognition receptors (PRRs), which are expressed on cell membrane or in the cytoplasm of cells of the innate immune system. Nucleic acids derived from pathogens or from certain cellular conditions represent a large category of PAMPs/DAMPs that trigger production of type I interferons (IFN-I) in addition to pro-inflammatory cytokines, by specifically binding to intracellular Toll-like receptors or cytosolic receptors. These cytosolic receptors, which are

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11

Chao, Ping. "Molecular basis of PKR activation by Interferon-gamma (IFNγ) mRNA 5’-UTR". Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/molecular-basis-of-pkr-activation-by-interferongamma-ifn-mrna-5utr(76530b0e-e02f-4d59-8d38-4a2ba46fe741).html.

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PKR is an interferon (IFN)-induced protein kinase that is activated by double-stranded RNA in a mechanism involving binding of the N-terminal domain of PKR, protein dimerization and autophosphorylation. PKR is a key component of the cellular antiviral response and plays critical roles in a variety of other cellular processes including signal transduction, growth and apoptosis. Once activated, PKR phosphorylates its substrate, translation initiation factor (eIF2) on its alpha subunit at Ser51, thereby leading to an inhibition of protein synthesis. The IFN-gamma mRNA 5’-UTR, an H-type pesudoknot

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Antoniazzi, Alfredo Quites. "Função endócrina do interferon-tau durante o reconhecimento materno da gestação em ovinos." Universidade Federal de Santa Maria, 2010. http://repositorio.ufsm.br/handle/1/4049.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The objective of the present study is to evaluate interferon-tau (IFNT) endocrine action in extra uterine tissues. The first approach consists of collecting samples from ewes on days 12, 13, 14 and 15 of the estrous cycle or early pregnancy. The second, consists of installing osmotic pumps to deliver a continuous concentration of recombinant ovine (ro) IFNT into the uterine vein for 24 or 72 hours. Our hypothesis is that endocrine release of IFNT into the uterine vein occurs as early as Day 13 of pregnancy. Also, that 24 and 72 h

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13

Corbera, Bellalta Marc. "Regulació de l’activitat inflamatòria per IFN-gamma en l'Arteritis de Cèl·lules Gegants (ACG)." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/396137.

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L'ACG és una malaltia inflamatòria crònica de caràcter granulomatós, que afecta a les arteries grans i mitjanes en pacients d’edat avançada. El tractament majoritàriament establert per l'ACG són els glucocorticoides, que malgrat produir generalment una remissió ràpida dels símptomes, no eviten rebrots, i presenten una sèrie important d’efectes secundaris que fan necessària la investigació de teràpies alternatives. La investigació de nous tractaments requereix un coneixement més acurat sobre la patogènesi de la malaltia. La fisiopatologia de la malaltia es fonamenta en hipòtesis i deduccions

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14

Campbell, Gillian Mhairi. "Influenza virus infection in a compromised immune system." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6521.

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Severe influenza virus infection, including human infection with highly pathogenic H5N1 viruses is characterised by massive pulmonary inflammation, immunopathology and excessive cytokine production, a process in which macrophages may play a vital role. The aim of this project was to investigate the hypothesis that inhibition of inflammatory responses from infected macrophages, using either alternatively activated bone marrow derived macrophages (BMDMf), or IFNg receptor deficient (IFNgR-/-) mice may ameliorate the devastating immunopathology and inflammation routinely observed in highly pathog

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Santos, Tatiane Assone dos. "Associação dos polimorfismos de IFN-lambda 4, KIR e HLA-C em pacientes vivendo com HTLV-1." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/99/99131/tde-24012017-082140/.

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As doenças virais têm sido importantes causas de morbidade e mortalidade nas últimas décadas, sendo que algumas delas são relacionadas com polimorfismos genéticos, que determinam a susceptibilidade do hospedeiro ou a resistência a essas infecções, influenciando na patogênese, além de desempenhar importante papel em respostas ao tratamento. Entre elas, destaca-se o HTLV-1, sendo que cerca de 10 a 20 milhões de pessoas em todo o mundo possuem esse vírus. Apenas 5% dos indivíduos infectados desenvolverão algum tipo de doença relacionada a tal infecção, entre elas destaca-se a HAM/TSP. Apesar da c

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Zeer, Munir Ali al. "IFN[gamma] inducible GTPases mediate host Resistance against Chlamydia trachomatis via autophagy." Berlin mbv, 2009. http://d-nb.info/998054445/04.

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Prando, Carolina Cardoso de Mello. "O papel crucial do eixo IL 12/23-IFNy para o desenvolvimento e ativação do sistema NADPH oxidase humano." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308286.

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Orientador: Antonio Condino Neto<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-12T09:19:02Z (GMT). No. of bitstreams: 1 Prando_CarolinaCardosodeMello_D.pdf: 7021288 bytes, checksum: e93bf24a96be00102eb5a19f5d7c8880 (MD5) Previous issue date: 2008<br>Resumo: O sistema NADPH oxidase fagocítico humano possui um papel importante na defesa contra microorganismos intracelulares, incluindo micobactérias. Mutações nas subunidades deste sistema resultam na Doença Granulomatosa Crônica (DGC). O gene CYBB, localizado no cr

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Keller, Emma Jean. "The Contribution of IFNα-Stimulated Immune Cell Populations to B6.NbA2 Lupus-likeDisease". Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1625138193480211.

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19

Schoenborn, Jamie R. "Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing Ifng transcription /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/5098.

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20

Sahin, Ebru Karpuzoglu. "Estrogen Regulates Interferon-gamma (IFN-g) and IFN-g-Inducible iNOS Gene Expression: Implications to Immunity and Autoimmunity." Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/27129.

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It is now clear that estrogen not only modulates the differentiation and function of reproductive systems, but it also profoundly regulates the immune system of normal and autoimmune individuals. An important mechanism by which estrogen regulates the immune system is by altering the secretion and/or response to cytokines. We hypothesized that estrogen may alter the levels and/or response to IFN-g, a prototype Th1 cytokine, that plays a pivotal role in immunity against intracellular infections and in many autoimmune and inflammatory disorders. We found that estrogen treatment tended to upregula

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21

Gage, Zoe O. "Interferon, viruses and drug discovery." Thesis, University of St Andrews, 2017. http://hdl.handle.net/10023/10127.

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The interferon (IFN) response is a crucial component of cellular innate immunity, vital for controlling virus infections. Dysregulation of the IFN response however can lead to serious medical conditions including autoimmune disorders. Modulators of IFN induction and signalling could be used to treat these diseases and as tools to further understand the IFN response and viral infections. We have developed cell-based assays to identify modulators of IFN induction and signalling, based on A549 cell lines where a GFP gene is under the control of the IFN-β promoter (A549/pr(IFN-β).GFP) and the ISRE

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22

Santillo, Bruna Tereso. "Caracterização fenotípica e funcional de IFN-DCs derivadas de indivíduos infectados pelo HIV-1." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-09122015-130521/.

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A imunoterapia baseada em MoDC constitui uma estratégia para tratamento de indivíduos HIV+. Protocolos para obtenção de MoDC em geral utilizam IL-4 e GM-CSF (IL4-DC). Alguns estudos utilizam as IFN-DC (IFN-α + GM-CSF), que exibem um fenótipo combinado de DC mielóide, DC plasmocitóide (pDC) e célula NK. Esse perfil misto pode aperfeiçoar a imunoterapia para pacientes HIV+. Para tanto, monócitos de pacientes HIV+ foram cultivados com GM-CSF e IL-4 ou IFN-α por 5 dias e estimuladas por 48 horas com pulso de HIV inativado por AT-2 e/ou coquetel de citocinas pró-inflamatórias. Avaliamos

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23

Bucci, Daniella Zanetti. "Ação do IFN-g sobre as células não leucocitárias (células estruturais) na infecção pelos protozoários Trypanosoma cruzi e Plasmodium." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-06012015-140117/.

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O objetivo central desta dissertação de mestrado foi analisar se, pela sua resposta ao interferon-g (IFNg), as células não leucocitárias contribuem ao controle dos protozoários Trypanosoma cruzi, Plasmodium chabaudi AS e Plasmodium berghei ANKA. O IFNg é uma citocina que promove a ativação de diversos tipos de leucócitos, a sua ação sobre as células mononucleares fagóciticas merece um destaque especial. Apesar de conhecermos os pormenores do papel desta citocina na ativação dos leucócitos, desconhecemos se o IFNg exerce ação ativadora sobre as células estruturais (não leucocitárias), ou seja,

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Koch, Oliver. "Common genetic variants of the IFN-γ and IFNGR1 regions : disease associations and functional properties". Thesis, University of Oxford, 2003. http://ora.ox.ac.uk/objects/uuid:30fc15ae-13e5-4150-8093-2582334e75c0.

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There is growing evidence that susceptibility to many inflammatory and infectious diseases may be influenced by our genetic make up. Genetic variants in important immune genes may partially explain variation in susceptibility to common diseases. Interferon-γ (IFNγ) is one of the central mediators of the innate and adaptive immunity and has been implicated in a wide range of infectious and inflammatory disease processes. Severe disruptive mutations in coding regions of the IFN-γ receptor 1 gene (IFNGR1) have been found to be associated with fatal but very rare mycobacterial infections. This stu

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Kotla, Swathi, and Kurt E. Gustin. "Proteolysis of MDA5 and IPS-1 is not required for inhibition of the type I IFN response by poliovirus." BioMed Central, 2015. http://hdl.handle.net/10150/610336.

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BACKGROUND: The type I interferon (IFN) response is a critical component of the innate immune response to infection by RNA viruses and is initiated via recognition of viral nucleic acids by RIG-like receptors (RLR). Engagement of these receptors in the cytoplasm initiates a signal transduction pathway leading to activation of the transcription factors NF-κB, ATF-2 and IRF-3 that coordinately upregulate transcription of type I IFN genes, such as that encoding IFN-β. In this study the impact of poliovirus infection on the type I interferon response has been examined. METHODS: The type I IFN resp

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Stewart, Claire Emma. "Viruses and the interferon (IFN) response : methods to improve production and to rapidly select IFN-sensitive viruses for vaccine development." Thesis, University of St Andrews, 2017. http://hdl.handle.net/10023/11346.

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Manipulation of a virus's capacity to circumvent the interferon (IFN) response aids both fundamental studies as well as many practical applications including the design of live-attenuated vaccines. However, these IFN-sensitive viruses are often difficult to grow to high titer in cells that produce and respond to IFN. In the first part of this study we further characterised the use of the IFN inhibitor, Ruxolitinib (Rux) for its ability to block the IFN response and subsequently enhance replication of IFN-sensitive viruses. This study has shown that i) Rux could provide a more rapid and therefo

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McCann, Katelyn J. "IFNγ Mediated Monocyte Metabolic Reprogramming". eScholarship@UMMS, 2021. https://escholarship.umassmed.edu/gsbs_diss/1146.

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IFNγ is an essential and pleiotropic activator of monocytes, but little is known about the effects IFNγ on cellular metabolism. Therefore, we sought to characterize and elucidate the mechanisms by which IFNγ reprograms monocyte metabolism to support its immunologic activities. First, we identified a critical role for IFNγ in the induction of immunoresponsive gene 1 (IRG1) and its product, itaconate. The immunometabolite, itaconate, has been reported to have antibacterial, anti-inflammatory and antioxidant activity. Irg1-/- mice, lacking itaconate, are highly susceptible and phenotypically simi

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Santos, Michelle Carolina dos [UNIFESP]. "Avaliação das populações de linfócitos produtores de IFN-g e IL-17 em pacientes sépticos e relação com o desfecho clínico." Universidade Federal de São Paulo (UNIFESP), 2010. http://repositorio.unifesp.br/handle/11600/9057.

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Made available in DSpace on 2015-07-22T20:49:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-07-28<br>A resposta inflamatória é modulada durante a sepse e a regulação positiva ou negativa da atividade celular depende das células e funções avaliadas. IFN-γ e IL-17 são citocinas características das subpopulações de linfócitos Th1 e Th17, respectivamente, e desempenham papel importante na resposta imune, ligando a imunidade inata e adaptativa. Objetivo: Avaliar a presença das células Th1 e Th17 em pacientes sépticos na admissão do estudo (D0) comparado-a com sadios e após 7 dias (D7)

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Amalraj, James. "Gene Regulation Associated with IFN-Resistance Mechanisms in Melanoma." Thesis, Griffith University, 2012. http://hdl.handle.net/10072/366926.

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Melanoma is the most aggressive form of skin cancer with rapidly increasing rates of incidence in fair-skinned populations worldwide. The most promising current treatment for advanced stage melanoma involves a combination of chemotherapy and interferon alpha (IFN-α), although complete response rates are unacceptably low. Loss of sensitivity to IFNs in melanoma cells has been shown to arise from a deficiency in the level of intracellular signalling molecules including STAT1, STAT2 & IRF9, which are important transcription factors in the IFN signalling pathway. Of these, deficiencies in STAT1 sh

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Castro, Analia Zuleika de. "Imunidade celular de pacientes portadores de Tuberculose pulmonar. Participação do fator transformador de crescimento beta (TGF-beta) e interferon gama (IFN-gama)." [s.n.], 1997. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316936.

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Orientadores: Leonilda Maria Barbosa Santos, Ilma Aparecida Paschoal<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-07-22T08:08:39Z (GMT). No. of bitstreams: 1 Castro_AnaliaZuleikade_M.pdf: 5313468 bytes, checksum: 7ab49045ee18e55595dcf9f1515981c3 (MD5) Previous issue date: 1997<br>Mestrado<br>Imunologia<br>Mestre em Ciências Biológicas

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Pina, Lígia Isabel Gomes de. "Esclerose múltipla: terapêutica com IFN-β". Master's thesis, [s.n.], 2012. http://hdl.handle.net/10284/3202.

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Trabalho apresentado à Universidade Fernando Pessoa, como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>A esclerose múltipla (EM) é a doença crónica mais comum do sistema nervoso central (SNC) e é caracterizada pela destruição da mielina. Hoje em dia é objecto de inúmeras pesquisas para determinar com precisão as suas causas e definir um tratamento eficaz. A diferente susceptibilidade à doença entre homens e mulheres, negros e caucasianos, jovens e idosos e a distribuição geográfica díspar da EM parece sugerir uma interacção efectiva entre factores genéticos

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Ferreira, Márcio José. "Expressão de IFN-gama e interleucina (IL)-10 e seus receptores pelas células trofoblásticas de camundongos." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-03062008-110226/.

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Analisamos a expressão de IL-10, IFN-<font face=\"symbol\">g e, seus receptores pelas células trofoblásticas de camundongos, citocinas anti e pró-inflamatórias. Cones ectoplacentários aos 7,5 dias de gestação foram cultivados por 48 h e em seguida tratados com 100 U/mL IFN-<font face=\"symbol\">g ou 10 <font face=\"symbol\">hg/mL IL-10. Após 6 h e 14 h, as amostras foram processadas para análise da expressão gênica por RT-PCR e protéica por imunohistoquímica, respectivamente. Grupos controle não receberam tratamento. IFN-<font face=\"symbol\">g aumentou a expressão de IL-10R1 mas não a de IL-1

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Jesus, Luciano Augusto Oliveira de. "ProduÃÃo de ifn-y em pacientes com hansenÃase e em seus contactantes numa amostra populacional do MunicÃpio de Sobral - CearÃ." Universidade Federal do CearÃ, 2007. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=1242.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>A hansenÃase, cujo agente etiolÃgico Ã o Mycobacterium leprae, Ã doenÃa de amplo espectro clÃnico e imunopatolÃgico. Suas apresentaÃÃes clÃnicas estÃo correlacionadas com padrÃes imunolÃgicos distintos, variando de uma vigorosa resposta imune mediada por cÃlulas ao M. leprae, com padrÃo tipo 1 no polo tuberculÃide, a uma ausÃncia de resposta celular especÃfica aos antÃgenos do M. leprae no pÃlo lepromatoso, com predomÃnio de resposta tipo 2 e exacerbaÃÃo da resposta humoral. A capacidade do antÃgeno bruto de M. leprae em estimula

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Eboumbou, Moukoko Else Carole. "Evaluation des effets de polymorphismes génétiques (TNF-alpha, IFN-gamma, IFN-gamma R1) et de coinfections virales (VHB, VHC) sur la fibrose de symmers." Paris 6, 2003. http://www.theses.fr/2003PA066106.

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Sidwaba, Unathi. "Electrochemical poly(ProDOT) dendritic DNA aptamer biosensor for signalling interferon gamma (IFN-ɣ) TB biomarker". University of the Western Cape, 2017. http://hdl.handle.net/11394/5507.

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Philosophiae Doctor - PhD<br>Tuberculosis (TB) is an infectious disease that, despite all efforts devoted towards its eradication, remains a threat to many countries including South Africa. Current diagnostic assays do offer better performance than the conventional sputum smear microscopy and tuberculin skin tests. However, these assays have been proven to be affected by various factors including the condition of an individual's immune system and vaccination history. By far, electrochemical biosensors are amongst the currently investigated techniques to address the shortcomings associate

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Velloso, Álvaro Jorge. "Estudo da infecção pelo TMEV em culturas de células BHK-21 para avaliar a atividade terapêutica do IFN-Β humano na esclerose múltipla". Instituto de Tecnologia em Imunobiológicos, 2009. https://www.arca.fiocruz.br/handle/icict/5827.

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LIPARI, Elisa. "DEVELOPMENT AND QUALIFICATION OF BIOANALYTICAL METHODS FOR DEAMIDATED IFNβ-1a AND INVESTIGATION ABOUT THE MECHANISM OF ACTION". Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/497430.

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Interferon beta-1a (IFNβ-1a) is a recombinant IFNβ with the tradename Rebif involved in several biological activities. Recently, it has been reported that artificial deamidation of IFNb-1a increases its biological response. Given the therapeutical potential, an investigation on the deamidated variant has been carried out via different approaches to discover the mechanism underlying this biological effect. The antiviral and immunomodulatory activity of deamidated cytokine was assessed using two precise and accurate cell-based assays. As expected, deamidated IFNβ-1a showed an increase in the bio

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Alshehri, Abdullateef Abdullah Salem. "Defining the Mechanism of ISGs Induction and Type I Interferon Inhibition in HIV-1 Infected Mononuclear Phagocytes." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/18192.

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Dendritic cells (DC) and macrophages are mononuclear phagocytes present in the tissues of the anogenital tract where HIV-1 transmission occurs in almost all cases. These cells are both target cells for HIV-1 and act as the primary opportunity for the virus to inhibit the innate recognition. Our lab has previously shown that both cell types fail to produce type I interferons (IFN) in response to HIV-1. However, it stimulates them to produce specific subsets of interferonstimulated genes (ISGs) some of which have direct antiviral activity. Our lab defined the precise stage in the IFN inducing s

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Schroder, Kate. "Mechanisms of IFN[gamma] priming of macrophage activation by CpG DNA /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18684.pdf.

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Sang, Wenjing. "Differential expression of type I interferons in fetal tissues and the maternal-fetal interface in response to PRRSV infection." Thesis, Kansas State University, 2012. http://hdl.handle.net/2097/14183.

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Master of Science<br>Department of Diagnostic Medicine/Pathobiology<br>Raymond R. R. Rowland<br>Interferons (IFNs) comprise a group of antiviral cytokines; however, their expression at the porcine maternal-fetal interface and in fetal tissues has not previously been investigated. The purpose of this study was to analyze the expression of type I IFNs and their receptors in maternal and fetal tissues from sows infected with PRRSV. The approach was to use real-time RT-PCR to identify the expression of different subtypes of type I IFN genes. The results show that the constitutive gene expression o

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Li, Wen. "Investigation of Type I Interferon Signaling in the Cellular Response and Host Defense." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/10615.

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Type I interferons (IFN-I) mediate the antiviral host response through activation of interferon-stimulated gene factor 3 (ISGF3) complex consisting of STAT1, STAT2 and IRF9. However, IFN-I can activate a number of non-canonical signaling pathways, which may contribute to neurological diseases in transgenic mice with CNS-production of IFN-α. It remained largely unknown how and to what extent non-canonical signaling pathways mediate the functional effects of IFN-I. Thus, the role of IFN-α-stimulated ISGF3-independent gene regulation was investigated in murine primary mixed glial cells (MGCs) in

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CARLETTI, TEA. "The Unfolded Protein Response is required early during TBEV infection to trigger the interferon response." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908030.

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Flaviviruses are a major cause of disease in humans and animals worldwide. Tick-borne encephalitis virus (TBEV) is the most relevant arthropod-borne flavivirus endemic in Europe and is the etiological agent of tick-borne encephalitis, a potentially fatal infection of the central nervous system. In our recent work we demonstrated that TBEV is able to trigger the stress response of infected cells leading to the formation of stress granules (SG) (Albornoz et al. 2014). We also found that the formation of SG in TBEV infected cells is delayed, following the same delayed kinetic of the IFN response

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Jesus, Luciano Augusto Oliveira de. "Produção de ifn-y em pacientes com hanseníase e em seus contactantes numa amostra populacional do município de Sobral-Ceará." reponame:Repositório Institucional da UFC, 2007. http://www.repositorio.ufc.br/handle/riufc/1905.

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JESUS, Luciano Augusto Oliveira de. Produção de IFN-Y em pacientes com hanseníase e em seus contactantes numa amostra populacional do município de Sobral-Ceará. 2007. 96 f. Dissertação (Mestrado em Microbiologia Médica) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2007.<br>Submitted by denise santos (denise.santos@ufc.br) on 2012-01-05T13:09:34Z No. of bitstreams: 1 2007_dis_laojesus.pdf: 935043 bytes, checksum: 479087f2722a2585b7c5e90f41bdaeb4 (MD5)<br>Approved for entry into archive by Eliene Nascimento(elienegvn@hotmail.com) on 2012-02-02T16:26:31Z (GMT) No. of bits

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Frazão, Josias Brito. "Efeito do interferon-gamma sobre defeitos de \"splicing\" que levam à doença granulomatosa crônica ligada ao cromossomo X." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-07072009-130714/.

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Os fagócitos contêm uma nicotinamida adenina dinucleotídeo fosfato (NADPH) oxidase associada à membrana, que gera superóxido e outros reativos intermediários do oxigênio. Defeitos nesta oxidase em seres humanos resultam na doença granulomatosa crônica (DGC). Mutações próximas aos sítios de splicing que interferem com o processamento do RNA mensageiro, acarretando deleção de um ou mais exons, são cada vez mais freqüentes na literatura científica, nesses casos, os mecanismos moleculares que levam a DGC nem sempre são totalmente esclarecidos, assim como o efeito do IFN-g, seja sobre o processamen

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Lauw, Fanny Nadine. "IL-12, IL-18 and IFN-[gamma] in the immune response to bacterial infection." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/82623.

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Silva, Cláudia Maria de Melo. "Polimorfismos genéticos e associação com a produção de Interferon gama (IFN-γ) em pacientes com Tuberculose pulmonar". Universidade Federal do Amazonas, 2014. http://tede.ufam.edu.br/handle/tede/4766.

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Curtis, Rachael E. "Distribution of Cellular Interferon Beta (IFN-β) in Murine Fibroblast Cell Lines Upon Infection of HSV-1". Wright State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1323805692.

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Nakamura, Tetsuo. "Expression of Glycosylated Human Interferon-beta (IFN-β) in High Levels in Chinese Hamster Ovary (CHO) Cells". Kyoto University, 2000. http://hdl.handle.net/2433/151588.

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Raices, Raquel Marie. "A novel role for Il-1 cytokines and Tnf[alpha] in Ifn[gamma] production, which is mediated by I[kappa]b[zeta]." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1211994580.

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Ananthavettivelu, Gevitha [Verfasser], та Gisa [Akademischer Betreuer] Tiegs. "The role of interferon-gamma (IFNγ) in the immune pathogenesis of primary sclerosing cholangitis / Gevitha Ananthavettivelu ; Betreuer: Gisa Tiegs". Hamburg : Staats- und Universitätsbibliothek Hamburg, 2020. http://d-nb.info/121437039X/34.

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