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Journal articles on the topic 'Interleukin-10/biosynthesis'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Stahl, Matthias, Hua Cheng, Susanne Linde, and Jens Høiriis Nielsen. "Cortisol increases the susceptibility of rat islets to interleukin 1." Acta Endocrinologica 125, no. 4 (1991): 441–48. http://dx.doi.org/10.1530/acta.0.1250441.

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Abstract. Interleukin 1β has been proposed to play an essential role in the pathogenesis of IDDM by direct interaction with the pancreatic beta-cell. Glucocorticoids are widely used as immunosuppressive agents and have been suggested to interfere both with the production and action of interleukin 1. The aim of the present study was to evaluate the interaction between cortisol and interleukin-1 on the pancreatic beta-cell function in vitro. Newborn rat islets were precultured for seven days before they were exposed to interleukin 1 with or without addition of cortisol. The release of insulin to

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2

Huang, Chun-Jen, Bruce R. Stevens, R. Barton Nielsen, et al. "Interleukin-10 Inhibition of Nitric Oxide Biosynthesis Involves Suppression of CAT-2 Transcription." Nitric Oxide 6, no. 1 (2002): 79–84. http://dx.doi.org/10.1006/niox.2001.0402.

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3

Fauser, Bart C. J. M., A. Brenda Galway та Aaron J. W. Hsueh. "Inhibitory actions of interleukin-1β on steroidogenesis in primary cultures of neonatal rat testicular cells". Acta Endocrinologica 120, № 4 (1989): 401–8. http://dx.doi.org/10.1530/acta.0.1200401.

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Abstract. Interleukin-1 is an important cytokine produced by activated macrophages. Because macrophages have been localized in the testis and interleukin-1 bioactivity has been observed in the testis, the potential effect of interleukin-1 on gonadotropin-stimulated androgen production was investigated using primary cultures of neonatal rat testis cells. Cells were incubated for 3 days before change of medium and treatment with human chorionic gonadotropin and interleukin-1. After 3 additional days medium testosterone and progesterone levels were determined. Human chorionic gonadotropin treatme

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4

Petsini, Filio, Maria Detopoulou, Maria Choleva, Ioannis K. Kostakis, Elizabeth Fragopoulou, and Smaragdi Antonopoulou. "Exploring the Effect of Resveratrol, Tyrosol, and Their Derivatives on Platelet-Activating Factor Biosynthesis in U937 Cells." Molecules 29, no. 22 (2024): 5419. http://dx.doi.org/10.3390/molecules29225419.

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Platelet-activating factor (PAF) is a potent lipid mediator, involved in thrombosis, inflammation, and atherosclerosis. The protective effect of wine and olive oil against atherosclerotic diseases is largely attributed to their phenolic compounds and mostly to resveratrol and tyrosol. Both compounds have been reported to inhibit PAF biosynthesis in interleukin-1β (IL-1β)-stimulated monocytes and also to attenuate PAF biosynthesis in cell lysates. The aim of this study was to investigate the effects of resveratrol, tyrosol, and their derivatives on unstimulated U937 cells and to explore the int

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5

Deng, Jingti, Christian H. James, Lisa Patel, et al. "Human tribbles homologue 2 is expressed in unstable regions of carotid plaques and regulates macrophage IL-10 in vitro." Clinical Science 116, no. 3 (2009): 241–48. http://dx.doi.org/10.1042/cs20080058.

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Mammalian orthologues of the Drosophila tribbles protein (Trb1, Trb2 and Trb3) are a recently described family of signalling molecules that regulate gene expression by modulation of protein kinase signalling pathways. In the present study, a screen for mRNA species specifically regulated in vulnerable regions of human atherosclerotic plaque demonstrated the up-regulation of both Trb1 and Trb2, the latter by more than 8-fold. In vitro experiments in primary human monocyte-derived macrophages showed that Trb2 expression was up-regulated by treatment with oxidized LDL (low-density lipoprotein), a

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Lesnova, Ekaterina I., Olga V. Masalova, Kristina Yu Permyakova, et al. "Difluoromethylornithine (DFMO), an Inhibitor of Polyamine Biosynthesis, and Antioxidant N-Acetylcysteine Potentiate Immune Response in Mice to the Recombinant Hepatitis C Virus NS5B Protein." International Journal of Molecular Sciences 22, no. 13 (2021): 6892. http://dx.doi.org/10.3390/ijms22136892.

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Hepatitis C virus (HCV) is one of the main triggers of chronic liver disease. Despite tremendous progress in the HCV field, there is still no vaccine against this virus. Potential vaccines can be based on its recombinant proteins. To increase the humoral and, especially, cellular immune response to them, more effective adjuvants are needed. Here, we evaluated a panel of compounds as potential adjuvants using the HCV NS5B protein as an immunogen. These compounds included inhibitors of polyamine biosynthesis and urea cycle, the mTOR pathway, antioxidants, and cellular receptors. A pronounced sti

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7

Fan, ST, K. Hsia, and TS Edgington. "Upregulation of human immunodeficiency virus-1 in chronically infected monocytic cell line by both contact with endothelial cells and cytokines." Blood 84, no. 5 (1994): 1567–72. http://dx.doi.org/10.1182/blood.v84.5.1567.bloodjournal8451567.

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Cells of monocytic lineage (Mo) persistently infected with human immunodeficiency virus (HIV) have been suspected to be a major reservoir for in vivo transmission of virus to susceptible target cells. Cellular events and mechanisms that upregulate viral gene expression in such cells are important issues. Because the traffic of such cells is central to biodistribution of HIV, we have explored the impact of interaction of endothelium with HIV-1-infected U1 promonocytic cells. Coculturing of U1 with human umbilical endothelial cells (HUVEC) for 24 to 72 hours in the absence of stimulation induced

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8

Cheng, Yi-Lin, Chi-Yun Wang, Wei-Ching Huang та ін. "Staphylococcus aureus Induces Microglial Inflammation via a Glycogen Synthase Kinase 3β-Regulated Pathway". Infection and Immunity 77, № 9 (2009): 4002–8. http://dx.doi.org/10.1128/iai.00176-09.

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ABSTRACT A proinflammatory role for glycogen synthase kinase 3β (GSK-3β) has been demonstrated. Here, we addressed its roles on heat-inactivated Staphylococcus aureus-induced microglial inflammation. Heat-inactivated S. aureus induced tumor necrosis factor alpha (TNF-α) and nitric oxide (NO) production, at least in part, via a Toll-like receptor 2-regulated pathway. Neutralization of TNF-α largely blocked heat-inactivated S. aureus-induced NO. Heat-inactivated S. aureus activated GSK-3β, and inhibiting GSK-3β reduced TNF-α production as well as inducible NO synthase (iNOS)/NO biosynthesis. Whi

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9

Huang, Wei-Ching, Yee-Shin Lin, Chi-Yun Wang, et al. "Glycogen synthase kinase-3 negatively regulates anti-inflammatory interleukin-10 for lipopolysaccharide-induced iNOS/NO biosynthesis and RANTES production in microglial cells." Immunology 128, no. 1pt2 (2009): e275-e286. http://dx.doi.org/10.1111/j.1365-2567.2008.02959.x.

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10

Jenkins, C., W. Garcia, M. J. Godwin, et al. "Immunomodulatory Properties of a Viral Homolog of Human Interleukin-10 Expressed by Human Cytomegalovirus during the Latent Phase of Infection." Journal of Virology 82, no. 7 (2008): 3736–50. http://dx.doi.org/10.1128/jvi.02173-07.

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ABSTRACT Human cytomegalovirus (HCMV) establishes a latent infection in hematopoietic cells, from which it can reactivate to cause significant disease in immunocompromised individuals. HCMV expresses a functional homolog of the immunosuppressive cytokine interleukin-10 (termed cmvIL-10), and alternate splicing of the cmvIL-10 transcript results in expression of a latency-associated cmvIL-10 transcript (LAcmvIL-10). To determine whether LAcmvIL-10 encodes immunosuppressive functions, recombinant LAcmvIL-10 protein was generated, and its impact on major histocompatibility complex class II (MHC-I

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11

Alanazi, Samyah, Naif Alenzi, James Fearnley, William Harnett, and David G. Watson. "Temperate Propolis Has Anti-Inflammatory Effects and Is a Potent Inhibitor of Nitric Oxide Formation in Macrophages." Metabolites 10, no. 10 (2020): 413. http://dx.doi.org/10.3390/metabo10100413.

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Previous research has shown that propolis has immunomodulatory activity. Extracts from two UK propolis samples were assessed for their anti-inflammatory activities by investigating their ability to alter the production of the cytokines: tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, and IL-10 from mouse bone marrow-derived macrophages co-stimulated with lipopolysaccharide (LPS). The propolis extracts suppressed the secretion of IL-1β and IL-6 with less effect on TNFα. In addition, propolis reduced the levels of nitric oxide formed by LPS-stimulated macrophages. Metabolomic pro

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12

Fan, ST, K. Hsia, and TS Edgington. "Upregulation of human immunodeficiency virus-1 in chronically infected monocytic cell line by both contact with endothelial cells and cytokines." Blood 84, no. 5 (1994): 1567–72. http://dx.doi.org/10.1182/blood.v84.5.1567.1567.

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Abstract Cells of monocytic lineage (Mo) persistently infected with human immunodeficiency virus (HIV) have been suspected to be a major reservoir for in vivo transmission of virus to susceptible target cells. Cellular events and mechanisms that upregulate viral gene expression in such cells are important issues. Because the traffic of such cells is central to biodistribution of HIV, we have explored the impact of interaction of endothelium with HIV-1-infected U1 promonocytic cells. Coculturing of U1 with human umbilical endothelial cells (HUVEC) for 24 to 72 hours in the absence of stimulatio

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13

Yasuda, Emi, Masaki Serata, and Tomoyuki Sako. "Suppressive Effect on Activation of Macrophages by Lactobacillus casei Strain Shirota Genes Determining the Synthesis of Cell Wall-Associated Polysaccharides." Applied and Environmental Microbiology 74, no. 15 (2008): 4746–55. http://dx.doi.org/10.1128/aem.00412-08.

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ABSTRACT Although many Lactobacillus strains used as probiotics are believed to modulate host immune responses, the molecular natures of the components of such probiotic microorganisms directly involved in immune modulation process are largely unknown. We aimed to assess the function of polysaccharide moiety of the cell wall of Lactobacillus casei strain Shirota as a possible immune modulator which regulates cytokine production by macrophages. A gene survey of the genome sequence of L. casei Shirota hunted down a unique cluster of 10 genes, most of whose predicted amino acid sequences had simi

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14

Gronert, Karsten, Andrew Gewirtz, James L. Madara та Charles N. Serhan. "Identification of a Human Enterocyte Lipoxin A4 Receptor That Is Regulated by Interleukin (IL)-13 and Interferon γ and Inhibits Tumor Necrosis Factor α–induced IL-8 Release". Journal of Experimental Medicine 187, № 8 (1998): 1285–94. http://dx.doi.org/10.1084/jem.187.8.1285.

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Epithelial cells of the alimentary tract play a central role in mucosal immunophysiology. Pathogens and/or agonists that interact with mucosal surfaces often elicit epithelial responses that upregulate inflammation. Therefore, it was of interest to explore potential epithelial targeted antiinflammatory signals. Here we identified and sequenced a human enterocyte lipoxin (LX) A4 [5(S),6(R),15(S)-trihydroxy-7,9,13-trans-11-cis eicosatetraenoic acid] receptor, and demonstrate that transcription of this receptor was controlled by cytokines, of which lymphocyte-derived interleukin (IL)-13 and inter

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15

Fujimori, Y., M. Ogawa, SC Clark, and GJ Dover. "Serum-free culture of enriched hematopoietic progenitors reflects physiologic levels of fetal hemoglobin biosynthesis." Blood 75, no. 8 (1990): 1718–22. http://dx.doi.org/10.1182/blood.v75.8.1718.1718.

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Abstract Adult erythroid progenitors produce significantly higher fetal hemoglobin (HbF) levels in cultures containing fetal calf serum (FCS) and erythropoietin (Ep) than in vivo. The precise mechanisms for this increased HbF production in culture have not been elucidated. We examined HbF biosynthesis by enriched human progenitors in serum-free (SF) culture. We measured globin chain biosynthesis by combination of isoelectric focusing and autoradiography and examined percent nucleated erythrocytes containing HbF (%FNRBC) using microscopic immunodiffusion. CD34 (My10)-positive marrow cells from

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16

Fujimori, Y., M. Ogawa, SC Clark, and GJ Dover. "Serum-free culture of enriched hematopoietic progenitors reflects physiologic levels of fetal hemoglobin biosynthesis." Blood 75, no. 8 (1990): 1718–22. http://dx.doi.org/10.1182/blood.v75.8.1718.bloodjournal7581718.

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Adult erythroid progenitors produce significantly higher fetal hemoglobin (HbF) levels in cultures containing fetal calf serum (FCS) and erythropoietin (Ep) than in vivo. The precise mechanisms for this increased HbF production in culture have not been elucidated. We examined HbF biosynthesis by enriched human progenitors in serum-free (SF) culture. We measured globin chain biosynthesis by combination of isoelectric focusing and autoradiography and examined percent nucleated erythrocytes containing HbF (%FNRBC) using microscopic immunodiffusion. CD34 (My10)-positive marrow cells from a normal

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17

Muraki, Takeshi, Ko Fujimori, Mami Ishizaka та ін. "Effects of Interleukin-1β and Prostaglandin E2 on Prostaglandin D Synthase Production in Cultivated Rat Leptomeningeal Cells". Journal of Cerebral Blood Flow & Metabolism 24, № 4 (2004): 409–18. http://dx.doi.org/10.1097/00004647-200404000-00006.

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Although the interleukin (IL)-1 receptor is densely distributed in the leptomeninges constituting the blood/cerebrospinal fluid barrier, its physiologic significance has remained unclear. In the present study, we show that in cultured leptomeningeal cells, IL-1β, tumor necrosis factors, or lipopolysaccharide causes a prominent increase in the synthesis and release of prostaglandin (PG) D synthase, which catalyzes the final step in the biosynthesis of PGD2. Although significant increases in the amount of PGD synthase were also observed with cells exposed to somatostatin, thrombin, or ciliary ne

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18

Keller, Christopher C., James B. Hittner, Benjamin K. Nti, J. Brice Weinberg, Peter G. Kremsner, and Douglas J. Perkins. "Reduced Peripheral PGE2 Biosynthesis in Plasmodium falciparum Malaria Occurs through Hemozoin-Induced Suppression of Blood Mononuclear Cell Cyclooxygenase-2 Gene Expression via an Interleukin-10-Independent Mechanism." Molecular Medicine 10, no. 1-6 (2004): 45–54. http://dx.doi.org/10.2119/2004-00035.perkins.

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19

Aliberti, Julio, Charles Serhan, and Alan Sher. "Parasite-induced Lipoxin A4 Is an Endogenous Regulator of IL-12 Production and Immunopathology in Toxoplasma gondii Infection." Journal of Experimental Medicine 196, no. 9 (2002): 1253–62. http://dx.doi.org/10.1084/jem.20021183.

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The production of interleukin (IL)-12 is critical for the development of interferon (IFN)-γ–dependent resistance to Toxoplasma gondii. Nevertheless, when this response is dysregulated, such as occurs in the absence of IL-10, the uncontrolled inflammation that results can have lethal consequences for the host. Recently, we demonstrated that lipoxin (LX)A4, an eicosanoid mediator that depends on 5-lipoxygenase (LO) for its biosynthesis, exerts a regulatory role on dendritic cell IL-12 production triggered artificially by a T. gondii extract. We now formally establish the physiological relevance

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20

Omarizadeh, Khaled, Mohammad Reza Farahpour, and Mahshid Alipour. "Topical Administration of an Ointment Prepared From Satureja sahendica Essential Oil Accelerated Infected Full-Thickness Wound Healing by Modulating Inflammatory Response in a Mouse Model." Wounds : a compendium of clinical research and practice 33, no. 12 (2021): 321–28. http://dx.doi.org/10.25270/wnds/321328.

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Introduction. Satureja sahendica has antibacterial and anti-inflammatory properties that can have beneficial effects for decreasing inflammation in infected wounds. Objective. This study was conducted to evaluate the effects of an ointment prepared from S sahendica essential oil (SSO) on an infected wound model in BALB/c mice. Materials and Methods. One full-thickness excisional skin wound was surgically created per animal and inoculated with 5 × 107 colony-forming units of Pseudomonas aeruginosa and Staphylococcus aureus. Following induction of the wound, the mice (N = 90) were treated with s

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Zou, M., and C. Anges. "Cell–Cell Interaction of Macrophages and Vascular Smooth Muscle Cells in the Synthesis of Leukotriene B4." Mediators of Inflammation 3, no. 4 (1994): 297–302. http://dx.doi.org/10.1155/s0962935194000414.

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Biosynthesis of LTB4during cell-cell interaction between vascular smooth muscle cells (SMC) and alveolar macrophages (AM) has been investigated by use of both high-pressure Hquid chromatography (HPLC) and radtoimmunoassay (RIA). Both interleukin-β (IL-β) and tumour necrosis factor-α (TNFα) induced a time- and dose-dependent synthesis of 15-, and 5-hydroxyeicosatetraenoic acids (HETEs) from cultured SMC. However, neither TNFα nor IL-1β induced a significant LTB4production in SMC alone or AM alone after 24 h of incubation. Addition of IL-1β and TNFα simultaneously to SMC resulted in a dose-depen

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Shi, Changgui, Huiqiao Wu, Di Du та ін. "Nicotinamide Phosphoribosyltransferase Inhibitor APO866 Prevents IL-1β-Induced Human Nucleus Pulposus Cell Degeneration via Autophagy". Cellular Physiology and Biochemistry 49, № 6 (2018): 2463–82. http://dx.doi.org/10.1159/000493843.

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Background/Aims: Intervertebral discs consist of an extracellular matrix (ECM) with a central gelatinous nucleus pulposus (NP) enclosed in an outer layer known as the annulus fibrosus. ECM metabolic disorders result in loss of boundary between the annulus fibrosus and NP, which can lead to intervertebral disc degeneration (IDD). Proinflammatory cytokines, such as interleukin (IL)-1β, mediate the progression of IDD. Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the first step in the biosynthesis of nicotinamide adenine dinucleotide (NAD) and is known to be induced by IL-1β. APO866 is

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23

Zhao, Qun, Xianxi Wang, Leif D. Nelin, et al. "MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock." Journal of Experimental Medicine 203, no. 1 (2005): 131–40. http://dx.doi.org/10.1084/jem.20051794.

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Septic shock is a leading cause of morbidity and mortality. However, genetic factors predisposing to septic shock are not fully understood. Excessive production of proinflammatory cytokines, particularly tumor necrosis factor (TNF)-α, and the resultant severe hypotension play a central role in the pathophysiological process. Mitogen-activated protein (MAP) kinase cascades are crucial in the biosynthesis of proinflammatory cytokines. MAP kinase phosphatase (MKP)-1 is an archetypal member of the dual specificity protein phosphatase family that dephosphorylates MAP kinase. Thus, we hypothesize th

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Fabricio, Aline S. C., Giuseppe Tringali, Giacomo Pozzoli, et al. "Interleukin-1 mediates endothelin-1-induced fever and prostaglandin production in the preoptic area of rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 290, no. 6 (2006): R1515—R1523. http://dx.doi.org/10.1152/ajpregu.00604.2005.

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The intracerebroventricular injection of endothelin-1 (ET-1) induces fever and increases PG levels in the cerebrospinal fluid of rats. Likewise, the injection of IL-1 into the preoptic area (POA) of the rat hypothalamus causes both fever and increased PG production. In this study, we conducted in vivo and in vitro experiments in the rat to investigate 1) the hypothalamic region involved in ET-1-induced fever and PG biosynthesis and 2) whether hypothalamic IL-1 plays a role as a mediator of the above ET-1 activities. One hundred femtomoles of ET-1 increased body temperature when injected in the

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Goretzki, Alexandra, Yen-Ju Lin, Jennifer Zimmermann, et al. "Role of Glycolysis and Fatty Acid Synthesis in the Activation and T Cell-Modulating Potential of Dendritic Cells Stimulated with a TLR5-Ligand Allergen Fusion Protein." International Journal of Molecular Sciences 23, no. 20 (2022): 12695. http://dx.doi.org/10.3390/ijms232012695.

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Trained immune responses, based on metabolic and epigenetic changes in innate immune cells, are de facto innate immune memory and, therefore, are of great interest in vaccine development. In previous studies, the recombinant fusion protein rFlaA:Betv1, combining the adjuvant and toll-like receptor (TLR)5-ligand flagellin (FlaA) and the major birch pollen allergen Bet v 1 into a single molecule, significantly suppressed allergic sensitization in vivo while also changing the metabolism of myeloid dendritic cells (mDCs). Within this study, the immune–metabolic effects of rFlaA:Betv1 during mDC ac

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26

Beasley, D., and M. McGuiggin. "Interleukin 1 activates soluble guanylate cyclase in human vascular smooth muscle cells through a novel nitric oxide-independent pathway." Journal of Experimental Medicine 179, no. 1 (1994): 71–80. http://dx.doi.org/10.1084/jem.179.1.71.

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Recent demonstration of cytokine-inducible production of nitric oxide (NO) in vascular smooth muscle cells (VSMC) from rat aorta has implicated VSMC-derived NO as a key mediator of hypotension in septic shock. Our studies to determine whether an inducible NO pathway exists in human VSMC have revealed a novel cytokine-inducible, NO-independent pathway of guanylate cyclase activation in VSMC from human saphenous vein (HSVSMC). Interleukin 1 (IL-1), tumor necrosis factor (TNF), interferon gamma (IFN-gamma) and Escherichia coli lipopolysaccharide (LPS) increased cGMP at 24 h, whereas IL-2 and IL-6

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27

Chen, Zhen, Jiaoli Cheng, Xunqing Yin, et al. "Metabolic Profiling for Unveiling Mechanisms of Kushenol F against Imiquimod-Induced Psoriasis with UHPLC/MS Analysis." Molecules 29, no. 11 (2024): 2410. http://dx.doi.org/10.3390/molecules29112410.

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Psoriasis is a common chronic immune-mediated inflammatory skin disorder. Sophora flavescens Alt. (S. flavescens) has been widely acknowledged in the prevention and treatment of psoriasis. Kushenol F (KSCF) is a natural isopentenyl flavonoid extracted from the root of S. flavescens. We aimed to investigate the effect and mechanism of KSCF on imiquimod (IMQ)-induced psoriasis-like skin lesions in mice. A mouse model of psoriasis was induced with 5% IMQ for 5 days, and the mice were given KSCF dermally for 5 days. Changes in skin morphology, the psoriasis area, the severity index (PASI), and inf

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Dustin, M. L., R. Rothlein, A. K. Bhan, C. A. Dinarello, and T. A. Springer. "Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1)." Journal of Immunology 137, no. 1 (1986): 245–54. http://dx.doi.org/10.4049/jimmunol.137.1.245.

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Abstract ICAM-1 is a cell surface glycoprotein originally defined by a monoclonal antibody (MAb) that inhibits phorbol ester-stimulated leukocyte aggregation. Staining of frozen sections and immunofluorescence flow cytometry showed intercellular adhesion molecule-1 (ICAM-1) is expressed on non-hematopoietic cells such as vascular endothelial cells, thymic epithelial cells, certain other epithelial cells, and fibroblasts, and on hematopoietic cells such as tissue macrophages, mitogen-stimulated T lymphocyte blasts, and germinal center dendritic cells in tonsils, lymph nodes, and Peyer's patches

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Chavakis, Triantafyllos, Antje Willuweit, Florea Lupu, Klaus Preissner, and Sandip Kanse. "Release of Soluble Urokinase Receptor from Vascular Cells*." Thrombosis and Haemostasis 86, no. 08 (2001): 686–93. http://dx.doi.org/10.1055/s-0037-1616105.

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SummaryUrokinase-type plasminogen activator (uPA) and its cell surface-receptor (uPAR) regulate cellular functions linked to adhesion and migration and contribute to pericellular proteolysis in tissue remodelling processes. Soluble uPAR (suPAR) is present in the circulation, peritoneal and ascitic fluid and in the cystic fluid from ovarian cancer. We have investigated the origin and the vascular distribution of the soluble receptor, which accounts for 10-20% of the total receptor in vascular endothelial and smooth muscle cells. Phase separation analysis of the cell conditioned media with Trito

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Frankenberger, M., A. Pforte, T. Sternsdorf, B. Passlick, P. A. Baeuerle та H. W. Ziegler-Heitbrock. "Constitutive nuclear NF-κB in cells of the monocyte lineage". Biochemical Journal 304, № 1 (1994): 87–94. http://dx.doi.org/10.1042/bj3040087.

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In monocytes, the nuclear factor NF-kappa B has been invoked as an important transcription factor in the expression of cytokine genes, of cell-surface receptors and in the expression of human immunodeficiency virus. In such cells, DNA binding activity of NF-kappa B can be detected without intentional stimulation. In our studies, cells of the human monocytic line Mono Mac 6, cultured in medium containing fetal-calf serum and low levels of lipopolysaccharide (LPS), also exhibit such ‘constitutive’ NF-kappa B, as demonstrated by mobility-shift analysis of nuclear extracts. This nuclear NF-kappa B

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Rae, M. T., D. Niven, A. Ross та ін. "Steroid signalling in human ovarian surface epithelial cells: the response to interleukin-1α determined by microarray analysis". Journal of Endocrinology 183, № 1 (2004): 19–28. http://dx.doi.org/10.1677/joe.1.05754.

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The human ovarian surface epithelium (HOSE) is a common site of gynaecological disease including endometriosis and ovarian cancer, probably due to serial injury-repair events associated with successive ovulations. To comprehend the importance of steroid signalling in the regulation of the HOSE, we used a custom microarray to catalogue the expression of over 250 genes involved in the synthesis and reception of steroid hormones, sterols and retinoids. The array included a subset of non-steroidogenic genes commonly involved in pro-/anti-inflammatory signalling. HOSE cells donated by five patients

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Dumont, F. J., R. G. Palfree, and L. Z. Coker. "Phenotypic changes induced by interferon in resting T cells: major enhancement of Ly-6 antigen expression." Journal of Immunology 137, no. 1 (1986): 201–10. http://dx.doi.org/10.4049/jimmunol.137.1.201.

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Abstract The murine Ly-6 locus controls multiple cell surface antigenic specificities with distinct cellular and tissue distributions. Although the functions of Ly-6 antigens are unknown, several of these antigens represent interesting markers of T cell differentiation and activation. In this work we used a panel of monoclonal antibodies (MAb) in conjunction with flow cytofluorometry (FCF) analysis to investigate the effect of interferon (IFN) on the surface representation of T cell-associated Ly-6 antigens. It was found that in vitro treatment of purified T cells from both C57Bl/6 (Ly-6.2) an

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Eldridge, Ronald C., Yufen Lin, Nabil F. Saba, et al. "Abstract PO-038: Metabolic-inflammatory investigation of head and neck cancer patient reported neuropsychological factors via multiomics integration of the plasma metabolome, lipidome, and circulating inflammation cytokines." Clinical Cancer Research 29, no. 18_Supplement (2023): PO—038—PO—038. http://dx.doi.org/10.1158/1557-3265.aacrahns23-po-038.

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Abstract Background: Neuropsychological factors (NPF) (i.e., fatigue, pain, cognitive dysfunction, depression, stress, and sleep disturbance) are common in head and neck cancer (HNC) and often cluster together. They can impair a patient’s functional status and quality of life and are an obstacle to effective treatment and a full recovery. Metabolism and inflammation may be underlying mechanisms but may work differently across HPV-related and unrelated HNC. We explored the joint interaction of metabolism, inflammation, and NPF via a stratified multiomics network analysis of the pretreatment pla

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Xin, Zhongquan, Zhenya Zhai, Hongrong Long, et al. "Metabolic Profiling by UPLC–Orbitrap–MS/MS of Liver from C57BL/6 Mice with DSS-Induced Inflammatory Bowel Disease." Mediators of Inflammation 2020 (September 23, 2020): 1–13. http://dx.doi.org/10.1155/2020/6020247.

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Liver disorder often occurs in patients with inflammatory bowel disease (IBD); however, the changes in IBD-induced liver disorder at the intrinsic molecular level (chiefly metabolites) and therapeutic targets are still poorly characterized. First, a refined and translationally relevant model of DSS chronic colitis in C57BL/6 mice was established, and cecropin A and antibiotics were used as interventions. We found that the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in the liver tissues of mice were highly increased in the context of DSS treatment but were lowered by

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Hsieh, Fred H., Bing K. Lam, John F. Penrose, K. Frank Austen, and Joshua A. Boyce. "T Helper Cell Type 2 Cytokines Coordinately Regulate Immunoglobulin E–Dependent Cysteinyl Leukotriene Production by Human Cord Blood–Derived Mast Cells." Journal of Experimental Medicine 193, no. 1 (2001): 123–34. http://dx.doi.org/10.1084/jem.193.1.123.

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Human mast cells (hMCs) derived in vitro from cord blood mononuclear cells exhibit stem cell factor (SCF)-dependent comitogenic responses to T helper cell type 2 (Th2) cytokines. As cysteinyl leukotriene (cys-LT) biosynthesis is a characteristic of immunoglobulin (Ig)E-activated mucosal hMCs, we speculated that Th2 cytokines might regulate eicosanoid generation by hMCs. After passive sensitization for 5 d with IgE in the presence of SCF, anti-IgE–stimulated hMCs elaborated minimal cys-LT (0.1 ± 0.1 ng/106 hMCs) and abundant prostaglandin (PG)D2 (16.2 ± 10.3 ng/106 hMCs). Priming of hMCs by int

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Zhu, Yanbing, Guangming Sun, Luosang Dunzhu, et al. "Effects of Different Dietary Protein Level on Growth Performance, Rumen Fermentation Characteristics and Plasma Metabolomics Profile of Growing Yak in the Cold Season." Animals 13, no. 3 (2023): 367. http://dx.doi.org/10.3390/ani13030367.

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This experiment was aimed to compare the effects of two diets with different protein content on the growth performance, immune indexes, rumen fermentation characteristics and plasma metabolomics of growing yak in the cold season. A total of 24, 2-year-old healthy yaks with similar body weight (142.9 ± 3.56 kg) were randomly allocated to two isoenergetic diets with different protein content (10 vs 14%) according to a non-paired experimental design, and the protein of the diets was increased by increasing soybean meal, rapeseed meal and cottonseed meal. The growth performance experiment lasted 5

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Xu, Qing-Yu, Shu Sun, Yebo Peng та ін. "Single-Cell RNA Sequencing Uncovers Distinct Molecular Characteristics and Immune Suppression Profiling of AML with Retinoic Acid Receptor γ Rearrangement". Blood 144, Supplement 1 (2024): 5724. https://doi.org/10.1182/blood-2024-204959.

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Introduction: Acute myeloid leukemia (AML) with retinoic acid receptor γ (RARG) rearrangement presents clinical, morphological, and immunophenotypic features similar to classic acute promyelocytic leukemia (APL). However, AML with RARG rearrangement exhibits different transcriptomic features compared to APL with PML-RARA or non-APL AML using bulk-RNA sequencing. To explore the biological heterogeneity, a comprehensive single-cell RNA sequencing (scRNA-seq) is essential to elucidate the molecular and genetic landscape of this disease. Methods: A total of 10 participants (APL cases = 6, AML case

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Li, Li, Xiaoyu Guo, Yanli Zhao, et al. "Cecal Microbial Diversity and Metabolome Reveal a Reduction in Growth Due to Oxidative Stress Caused by a Low-Energy Diet in Donkeys." Antioxidants 13, no. 11 (2024): 1377. http://dx.doi.org/10.3390/antiox13111377.

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Dietary energy level plays an important role in animal growth and development. The present study investigated the effect of dietary energy on the growth performance, antioxidative state, and nutrient digestion of meat donkeys. It simultaneously explored the probable reason for cecal microbiota and metabolome. Twelve meat donkeys (male) aged 1 year with a similar weight (150 ± 25 kg) were divided into two treatment groups: low-energy group (E1) and high-energy group (E2). The experiment was divided into a 10-day pre-trial period and a 135-day trial period. Donkeys in the trial periods were fed

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Giamarellos-Bourboulis, Evangelos J., Helen Poulaki, Nikolaos Kostomitsopoulos, et al. "Effective Immunomodulatory Treatment of Escherichia coli Experimental Sepsis with Thalidomide." Antimicrobial Agents and Chemotherapy 47, no. 8 (2003): 2445–49. http://dx.doi.org/10.1128/aac.47.8.2445-2449.2003.

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ABSTRACT Thalidomide, an agent which inhibits biosynthesis of tumor necrosis factor alpha (TNF-α) and which is used to treat a variety of chronic inflammatory conditions, was investigated as therapy for experimental sepsis. Sepsis was induced by intraperitoneal injection of 107 CFU of Escherichia coli per kg of body weight to 80 Wistar rats divided into four groups. Group A consisted of 24 control animals that did not receive any pretreatment, group B consisted of 18 vehicle-treated control animals pretreated with seed oil, group C consisted of 30 rats administered thalidomide diluted in seed

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Clemente, M., I. Lopez-Vidriero, P. O'Gaora, et al. "200 IN VITRO EMBRYO PRODUCTION IS ASSOCIATED WITH DISTINCT ALTERATIONS IN THE TRANSCRIPTOME BETWEEN THE BLASTOCYST STAGE AND THE INITIATION OF ELONGATION IN CATTLE." Reproduction, Fertility and Development 23, no. 1 (2011): 199. http://dx.doi.org/10.1071/rdv23n1ab200.

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The majority of embryonic loss in cattle occurs before maternal recognition of pregnancy around Day 16 postconception. The origin of the embryo can have a significant impact on the dynamics of embryo mortality. The aim of the present study was to compare transcript profiles between Day 7 (spherical blastocyst) and Day 13 (ovoid conceptus) bovine embryos derived in vitro or in vivo using the bovine Affymetrix microarray. Subsequent mapping of these differentially expressed genes (DEG) into relevant functional groups and pathways using ingenuity pathway analysis would identify the most important

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Xie, Fengfeng, Liba Xu, Hua Zhu, et al. "Serum Metabolomics Based on GC-MS Reveals the Antipyretic Mechanism of Ellagic Acid in a Rat Model." Metabolites 12, no. 6 (2022): 479. http://dx.doi.org/10.3390/metabo12060479.

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Ellagic acid (EA) is a polyphenol dilactone that has been reported to have antipyretic, anti-inflammatory, anti-tumor, and antioxidant activities, but the mechanism of action has not been reported. In this study, serum metabolomics was used to explore the mechanism of EA on rat fever induced by beer yeast, and to screen out marker metabolites to provide a reference for the antipyretic effect of EA. The acute fever model of male Sprague Dawley rats involved subcutaneous injection with 20% aqueous suspension of yeast (15 mL/kg) in their back. At the same time of modeling, EA was given orally by

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Yang, Xuan, Shulan Su, Qingling Ren, et al. "BushenHuoxue Recipe for the Treatment of Prethrombotic State of ACA-Positive Recurrent Miscarriage via the Regulation of the PI3K-AKT Signaling Pathway." Evidence-Based Complementary and Alternative Medicine 2022 (February 14, 2022): 1–16. http://dx.doi.org/10.1155/2022/2385534.

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Background. Although the Bushen Huoxue (BSHX) recipe is commonly used for the effective treatment of the prethrombotic state of recurrent abortions, its mechanism of action is unclear. In this article, we investigated the therapeutic effects of BSHX on anti-cardiolipin antibody (ACA) positive recurrent miscarriage mice and the molecular mechanism involved in the treatment of the prethrombotic state of ACA-positive recurrent miscarriages based on the PI3K-Akt signaling pathway, to provide a scientific basis for clinical practice. Methods. An ACA-positive recurrent miscarriage mouse model and no

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Wu, R., J. An, and C. Wang. "AB0072 THE METABOLITES WERE ALTERED IN PATIENTS WITH RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1214.2–1215. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1763.

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BackgroundRheumatoid arthritis (RA) is characterized by persistent synovitis and abnormal antibodies production[1].The discovery of follicular helper T cells (Tfh) and follicular regulatory T cells (Tfr) has added a new understanding of the mechanisms of antibody production in RA such as anti-cyclic peptide containing citrulline (anti-CCP) [2]. The gut microbiota-derived metabolites are also important in regulating immune system to balance disease and health. And the altered gut microbiota-derived metabolites had been found in RA patients[3]. However, the relationship between gut microbiota-de

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Grosset, C., B. Jazwiec, JL Taupin, et al. "In vitro biosynthesis of leukemia inhibitory factor/human interleukin for DA cells by human endothelial cells: differential regulation by interleukin-1 alpha and glucocorticoids." Blood 86, no. 10 (1995): 3763–70. http://dx.doi.org/10.1182/blood.v86.10.3763.bloodjournal86103763.

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Endothelial cell (EC) may represent a major source of cytokines in the bone marrow. In this study we have examined the production and the regulation of the production of leukemia inhibitory factor/human interleukin for DA cells (LIF/HILDA) by EC. Human umbilical vein endothelial cells (HUVEC) were chosen as a working model as they are a well known source of cytokines. These cells secrete LIF/HILDA (90 pg/mL/10(6) cells/48 h) in basal conditions. This secretion is profoundly altered by interleukin-1 alpha (IL-1 alpha). Secretion of LIF/HILDA is increased threefold on stimulation with IL-1 alpha

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Karabela, Sophia, Chrysoula Kairi, Sophia Magkouta, et al. "Neutralization of tumor necrosis factor bioactivity ameliorates urethane-induced pulmonary oncogenesis in mice." Neoplasia (New York, N.Y.) 13, no. 12 (2011): 1143–51. https://doi.org/10.1593/neo.111224.

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Tumor necrosis factor (TNF) has been implicated in inflammation-associated tumor progression. Although multiple reports identified a role for TNF signaling in established cancers, few studies have assessed the impact of TNF blockade on early tumor formation promotion. We aimed at exploring the effects of TNF neutralization in a preclinical mouse model of lung carcinogenesis. For this, Balb/c mice (n = 42) received four weekly intraperitoneal urethane injections (1 g/kg) and twice-weekly intraperitoneal soluble TNF receptor (etanercept; 10 mg/kg) administered during tumor initiation/promotion,

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Potenza, Leonardo, Daniela Vallerini, Patrizia Barozzi, et al. "Protective T-Cell Responses to Several Recombinant Aspergillus Antigens May Be Detected Since the Onset of the Infection in Patients with Invasive Aspergillosis, and May Be Exploited for Therapeutic Purposes,." Blood 118, no. 21 (2011): 3229. http://dx.doi.org/10.1182/blood.v118.21.3229.3229.

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Abstract Abstract 3229 Introduction: Several studies have reported that different components of fungi of the genera Aspergillus spp may induce protective T-cell responses in either mouse models of invasive aspergillosis (IA) or in human healthy subjects. We evaluated the occurrence of Aspergillus-specific T-cell responses to different Aspergillus recombinant antigens in patients with proven IA, during the course of the IA, to identify the antigens most frequently targeted by protective immune responses. We characterized phenotypically and functionally such specific T cells. Finally, from perip

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McPherson, Eugene, R. Shuklar, S. Y. Huang, M. Grimbel, and E. Hazel. "Imatinib Resistance Restoration with Antioxidants and Immunomodulation in Patients with Chronic Myelogenous Leukemia (CML)." Blood 108, no. 11 (2006): 4818. http://dx.doi.org/10.1182/blood.v108.11.4818.4818.

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Abstract Imatinib mesylate (IM) is potent BCR/abl tyrosine kinase inhibitor in patients with chronic myelogenous leukemia (CML). It has remarkable frontline clinical effects in this disease, however, the leukemic cells become resistant to IM in both chronic and blast phases. BCR/abl kinase can induce reactive oxygen species (ROS) and promote self-mutation which subsequently render IM to resistance and failure to eliminate all leukemia cells. This mechanism of resistance in IM (mutation) is caused by oxidant damage to DNA with kinase domain mutations, reduced IM binding and kinase inhibition. A

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Kasza, A., R. Korpula-Mastalerz, S. Rose-John, and A. Dubin. "Biosynthesis and distribution of leucocyte elastase inhibitor. Production of recombinant inhibitor." Acta Biochimica Polonica 43, no. 3 (1996): 497–501. http://dx.doi.org/10.18388/abp.1996_4482.

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The horse leucocyte elastase inhibitor (HLEI), present in neutrophils, monocytes and bone marrow cells, is apparently a cytoplasmic protein which is not released from cells even in response to stimulation with lipopolysaccharide, phorbol ester, tumour necrosis factor alpha, interleukin-1 or elastin degradation products. Although no expression of the inhibitor was detected in neutrophils, both monocytes and bone marrow cells were efficient in its synthesis. Using a new expression vector pREST5d, recombinant inhibitor was produced in a large quantity in a soluble form, with a yield of 88 mg per

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SCHMIDLI, Robert S., Beverly E. FAULKNER-JONES, Leonard C. HARRISON, Roger F. L. JAMES, and Henry J. DeAIZPURUA. "Cytokine regulation of glutamate decarboxylase biosynthesis in isolated rat islets of Langerhans." Biochemical Journal 317, no. 3 (1996): 713–19. http://dx.doi.org/10.1042/bj3170713.

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Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease in which cytokines are thought to play an important role in β-cell destruction and immune regulation. A major target of β-cell autoimmunity in IDDM is the enzyme glutamate decarboxylase (GAD). We hypothesized that cytokines in the insulitis lesion modulate the synthesis of GAD. This may, in turn, modify the rate of β-cell destruction. Accordingly we cultured rat islets in the presence and absence of cytokines, and measured synthesis of both isoforms of GAD, GAD65 and GAD67, by [35S]methionine incorporation and immunoprecipitat

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Hagmann, W. "Cell proliferation status, cytokine action and protein tyrosine phosphorylation modulate leukotriene biosynthesis in a basophil leukaemia and a mastocytoma cell line." Biochemical Journal 299, no. 2 (1994): 467–72. http://dx.doi.org/10.1042/bj2990467.

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Mast cells, mastocytoma cells and basophil leukaemia cells are well-established producers of leukotrienes when grown and stimulated appropriately. I report that the cells' ability to produce leukotrienes is dependent on the cells' proliferative status or their provision with growth factors. Proliferating MC/9 and subconfluent RBL2H3 cells respond maximally to stimulation by 1 microM ionomycin with the production of 56 and 32 pmol of cysteinyl-leukotrienes/10(6) cells respectively. In contrast, confluent RBL2H3 or growth-arrested MC/9 cells lose their ability to generate leukotrienes in respons

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