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Journal articles on the topic 'Interleukin-28'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Wolk, Kerstin, Katrin Witte, and Robert Sabat. "Interleukin-28 and Interleukin-29: Novel Regulators of Skin Biology." Journal of Interferon & Cytokine Research 30, no. 8 (2010): 617–28. http://dx.doi.org/10.1089/jir.2010.0064.

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2

Luo, Qin, Yi Liu, Shuang Liu, Yibing Yin, Banglao Xu, and Ju Cao. "Interleukin 28 is a potential therapeutic target for sepsis." Clinical Immunology 205 (August 2019): 29–34. http://dx.doi.org/10.1016/j.clim.2019.05.012.

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3

Kempuraj, D., J. Donelan, S. Frydas, et al. "Interleukin-28 and 29 (IL-28 and IL-29): New Cytokines with Anti-Viral Activities." International Journal of Immunopathology and Pharmacology 17, no. 2 (2004): 103–6. http://dx.doi.org/10.1177/039463200401700201.

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4

Krasnova, T. N., L. M. Samokhodskaya, L. V. Ivanitsky, et al. "Impact of interleukin-10 and interleukin-28 gene polymorphisms on the development and course of lupus nephritis." Terapevticheskii arkhiv 87, no. 6 (2015): 40. http://dx.doi.org/10.17116/terarkh201587640-44.

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5

Lin, Shih-Chang, Chia-Chen Kuo, Jeng-Ting Tsao та Li-Jing Lin. "Profiling the expression of interleukin (IL)-28 and IL-28 receptor α in systemic lupus erythematosus patients". European Journal of Clinical Investigation 42, № 1 (2011): 61–69. http://dx.doi.org/10.1111/j.1365-2362.2011.02557.x.

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6

Naumnik, Wojciech, Elzbieta Chyczewska, Tomasz Izycki, and Jaroslaw Talalaj. "P-28 Interleukin 18 serum concentration during chemotherapy of lung cancer." Lung Cancer 41 (August 2003): S98. http://dx.doi.org/10.1016/s0169-5002(03)91997-0.

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Obremski, Kazimierz, Wojciech Trybowski, Paweł Wojtacha, Magdalena Gajęcka, Józef Tyburski, and Łukasz Zielonka. "The Effect of Zearalenone on the Cytokine Environment, Oxidoreductive Balance and Metabolism in Porcine Ileal Peyer’s Patches." Toxins 12, no. 6 (2020): 350. http://dx.doi.org/10.3390/toxins12060350.

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The aim of the present study was to determine the effect of zearalenone (ZEN), administered per os to gilts at doses equivalent to 50%, 100%, and 150% of no-observed-adverse-effect level (NOAEL) values for 14, 28, and 42 days during weaning, on changes in the parameters of the oxidoreductive balance, cytokine secretion, and basal metabolism in ileal Payer’s patches. Immunoenzymatic ELISA tests and biochemical methods were used to measure the concentrations of interleukin 1α, interleukin 1β, interleukin 12/23p40, interleukin 2, interferon γ, interleukin 4, interleukin 6, interleukin 8, tumor ne

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8

Srinidhi, B. V., G. John Fletcher, Jaiprasath Sachidanantham, et al. "Effect of Interleukin-28B Polymorphism on Interleukin-28 Expression and Immunological Recovery amongst HIV-1-Infected Individuals Following Antiretroviral Therapy." Indian Journal of Medical Microbiology 35, no. 4 (2017): 580–84. http://dx.doi.org/10.4103/ijmm.ijmm_17_299.

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Moore, Tiffany A., Adam J. Case, Therese L. Mathews, Crystal Modde Epstein, Katherine Laux Kaiser, and Matthew C. Zimmerman. "Interleukin-17A and Chronic Stress in Pregnant Women at 24–28 Weeks Gestation." Nursing Research 68, no. 2 (2019): 167–73. http://dx.doi.org/10.1097/nnr.0000000000000334.

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Wejnaruemarn, Salisa, Sirinporn Suksawatamnuay, Jakapat Vanichanan, Piyawat Komolmit, Sombat Treeprasertsuk, and Kessarin Thanapirom. "Association between serum endocan levels and organ failure in hospitalized patients with cirrhosis." PLOS ONE 19, no. 12 (2024): e0315619. https://doi.org/10.1371/journal.pone.0315619.

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Background & aims Acute-on-chronic liver failure is a syndrome characterized by organ failure and high short-term mortality. The lack of reliable biomarkers for the early detection of acute-on-chronic liver failure is a significant challenge. Endothelial dysfunction plays a key role in the development of organ failure. Serum endocan is a potential new biomarker for endothelial dysfunction. Therefore, this study aimed to assess the association between endocan and organ failure and 28-day mortality in patients with cirrhosis. Methods Hospitalized patients with cirrhosis with and without orga

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11

Corwin, Elizabeth J., Nancy Johnston, and Linda Pugh. "Symptoms of Postpartum Depression Associated With Elevated Levels of Interleukin-1 Beta During the First Month Postpartum." Biological Research For Nursing 10, no. 2 (2008): 128–33. http://dx.doi.org/10.1177/1099800408323220.

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Postpartum depression (PPD) is a devastating disorder that may carry lifetime consequences. Although several psychosocial risks for PPD have been identified, biological contributors are unclear. Elevated inflammatory cytokines contribute to depression in nonpregnant, nonpostpartum populations; yet, their role in PPD has been minimally studied. The objective of this study is to determine whether inflammatory cytokines early in the postpartum period contribute to the development of PPD. Women were recruited within 24 hr of delivery, and 26 provided urine for analysis of interleukin-1 beta (IL-1β

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12

Bykova, A. Yu, A. A. Kulesh, N. A. Kayleva, E. M. Kuklina та V. V. Shestakov. "Interrelation of the dynamics of serum concentrations of interleukin-1β, interleukin-6 and interleukin-10 with clinical data in acute ischemic stroke and the strategy of reperfusion therapy". Bulletin of Siberian Medicine 18, № 4 (2020): 16–25. http://dx.doi.org/10.20538/1682-0363-2019-4-16-25.

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Aim. To study the relationship between the dynamics of serum concentrations of interleukin-1β, interleukin-6 and interleukin-10 with clinical data in the acute period of ischemic stroke, and the strategy of reperfusion therapy.Materials and methods. In 28 patients with acute ischemic stroke, half of whom underwent intravenous thrombolysis, the concentration of interleukin-1β, interleukin-6 and interleukin-10 was assessed at admission, on the 3rd and 10th day of the disease.Results. The concentration of interleukin-1β and interleukin-6 decreases during the acute period of stroke. The concentrat

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13

Bublitz, MH, M. Carpenter, S. Amin, et al. "The role of inflammation in the association between gestational diabetes and obstructive sleep apnea: A pilot study." Obstetric Medicine 11, no. 4 (2018): 186–91. http://dx.doi.org/10.1177/1753495x18780095.

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Background Obstructive sleep apnea is associated with pregnancy complications including gestational diabetes. Mechanisms underlying the association between obstructive sleep apnea and gestational diabetes remain to be elucidated. Methods Twenty-three participants with gestational diabetes underwent home sleep apnea testing. Obstructive sleep apnea was defined as an apnea hypopnea index > 5. Fasting morning blood samples were measured using multianalyte profiling (xMAP) multiplexed bead array immunoassay for Interleukin 6, tumor necrosis factor-alpha, and Interleukin 8. Results Age, body mas

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14

Shah, Kevin, Richard J. Connolly, Taryn Chapman, Mark J. Jaroszeski, and Kenneth E. Ugen. "Electrogenetherapy of B16.F10 murine melanoma tumors with an interleukin-28 expressing DNA plasmid." Human Vaccines & Immunotherapeutics 8, no. 11 (2012): 1722–28. http://dx.doi.org/10.4161/hv.22560.

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15

Mrowczynski, Oliver, Russell Payne, Christine Mau, et al. "TMOD-28. INTERLEUKIN-13 TARGETED PSEUDOMONAS TOXIN TREATMENT OF MALIGNANT PERIPHERAL NERVE SHEATH TUMORS." Neuro-Oncology 19, suppl_6 (2017): vi260. http://dx.doi.org/10.1093/neuonc/nox168.1065.

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16

Garbuglia, A. R., F. Grasso, M. G. Donà, et al. "TT Virus Infection: Role of Interferons, Interleukin-28 and 29, Cytokines and Antiviral Proteins." International Journal of Immunopathology and Pharmacology 20, no. 2 (2007): 249–58. http://dx.doi.org/10.1177/039463200702000205.

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17

Ding, Song-Ze, Chi-Hin Cho, and Shiu-Kum Lam. "REGULATION OF INTERLEUKIN 6 PRODUCTION IN A HUMAN GASTRIC EPITHELIAL CELL LINE MKN-28." Cytokine 12, no. 7 (2000): 1129–35. http://dx.doi.org/10.1006/cyto.1999.0604.

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18

Ozguler, Ibrahim M., Oktay Burma, Ayhan Uysal, and Handan Akbulut. "Rosuvastatin Lowers Systemic Inflammatory Response in Coronary Artery Bypass Graft Accompanied by Cardiopulmonary Bypass Surgery: A Randomized Controlled Study." Clinical & Investigative Medicine 38, no. 4 (2015): 154. http://dx.doi.org/10.25011/cim.v38i4.24260.

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Purpose: Cardiopulmonary bypass (CPB) is commonly associated with a systemic inflammatory response that may lead to severe complications. Classic signs of systemic inflammatory response syndrome are complement activation and changes in cytokine and acute phase reactant levels. The effects of rosuvastatin after CPB on interleukin-6 (IL-6), interleukin-10 (IL-10), interleukin-18 (IL-18) and High Sensitivity C-Reactive Protein (hs-CRP) levels were investigated. Methods: Thirty-seven male and thirteen female patients (total=50) aged 42 to 78 years, who had coronary bypass surgery due to coronary a

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19

Kadhim, Maytham Khazaal, and Kais Kassim Ghaima. "Levels of IL-18 and IL-28 in thalassemia patients with viral infections." Edelweiss Applied Science and Technology 8, no. 3 (2024): 523–32. http://dx.doi.org/10.55214/25768484.v8i3.1678.

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Thalassemia is an inherited hemoglobin disorder that requires lifelong medical care. Patients with thalassemia are very prone to infections by viruses, which may exacerbate their condition, leading to serious complications. Knowledge of the immune response in these patients could be very helpful in the effective management of their disease. The levels of IL-18 and IL-28 were evaluated in thalassemia patients with different viral infections to assess their potential as biomarkers and therapeutic targets. This was a retrospective analysis of clinical data on thalassemia patients with viral infec

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20

Penedo‐Pita, Manuel, and Javier Peteiro‐Cartelle. "Increased Serum Levels of Interleukin‐2 and Soluble Interleukin‐2 Receptor in Celiac Disease." Journal of Pediatric Gastroenterology and Nutrition 12, no. 1 (1991): 56–60. http://dx.doi.org/10.1002/j.1536-4801.1991.tb10186.x.

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SummaryIgA anti‐gliadin antibodies (AGA), interleukin‐2 (IL‐2), and soluble interleukin‐2 receptor (sIL‐2R) were analyzed in serum from 28 children with symptoms of celiac disease and villous atrophy in at least their first small bowel biopsy. We also assayed IL‐2 and sIL‐2R in 45 healthy children and IgA anti‐gliadin antibodies in 145 healthy children. The serum levels of IL‐2, sIL‐2R, and AGA were significantly increased in celiac patients. The increase of IL‐2 and sIL‐2R levels suggests indirectly T‐cell activation in these patients. Receiver operating characteristic (ROC) curves were perfo

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21

Little, David, Saroj Khanolkar-Young, Anne Coulthart, Sujai Suneetha, and Diana N. J. Lockwood. "Immunohistochemical Analysis of Cellular Infiltrate and Gamma Interferon, Interleukin-12, and Inducible Nitric Oxide Synthase Expression in Leprosy Type 1 (Reversal) Reactions before and during Prednisolone Treatment." Infection and Immunity 69, no. 5 (2001): 3413–17. http://dx.doi.org/10.1128/iai.69.5.3413-3417.2001.

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ABSTRACT The effects of prednisolone treatment on the cellularity and cytokine (gamma interferon, interleukin-12, and inducible nitric oxide synthase) profiles of leprosy skin type 1 (reversal) reactions were studied using immunohistochemistry. Skin biopsies were taken from 15 patients with leprosy type 1 (reversal) reactions at days 0, 7, 28, and 180 after the start of steroid treatment. Prednisolone treatment had little effect at day 7, but by day 28 significant decreases were found in cytokine levels. Some patients maintained cytokine production at days 28 and 180. These results illustrate

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Andersen, Henrik U., Dídac Mauricio, Allan E. Karlsen, Thomas Mandrup-Poulsen, Jens H. Nielsen та Jørn Nerup. "Interleukin-1β-induced nitric oxide production from isolated rat islets is modulated by D-glucose and 3-isobutyl-1-methyl xanthine". European Journal of Endocrinology 134, № 2 (1996): 251–59. http://dx.doi.org/10.1530/eje.0.1340251.

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Andersen HU, Mauricio D, Karlsen AE, Mandrup-Poulsen T, Nielsen JH, Nerup J. Interleukin-nitric oxide production from isolated rat islets is modulated by d-glucose and 3-isobutyl-1-methyl xanthine. Eur J Endocrinol 1996:134:251–9. ISSN 0804–4643 Interleukin-1β has been proposed to cause selective β-cell destruction via the induction of nitric oxide synthesis. The cytotoxic effect of interleukin-1β is modulated by the concentration of d-glucose in the medium. The aim of this study was to investigate if d-glucose-mediated modulation of interleukin-1β effects on insulin release from isolated rat

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23

Almarghalani, Daniyah A., Xiaojin Sha, Robert E. Mrak, and Zahoor A. Shah. "Spatiotemporal Cofilin Signaling, Microglial Activation, Neuroinflammation, and Cognitive Impairment Following Hemorrhagic Brain Injury." Cells 12, no. 8 (2023): 1153. http://dx.doi.org/10.3390/cells12081153.

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Intracerebral hemorrhage (ICH) is a significant health concern associated with high mortality. Cofilin plays a crucial role in stress conditions, but its signaling following ICH in a longitudinal study is yet to be ascertained. In the present study, we examined the cofilin expression in human ICH autopsy brains. Then, the spatiotemporal cofilin signaling, microglia activation, and neurobehavioral outcomes were investigated in a mouse model of ICH. Human autopsy brain sections from ICH patients showed increased intracellular cofilin localization within microglia in the perihematomal area, possi

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24

Bauer, J., U. Ganter, T. Geiger, et al. "Regulation of interleukin-6 expression in cultured human blood monocytes and monocyte-derived macrophages." Blood 72, no. 4 (1988): 1134–40. http://dx.doi.org/10.1182/blood.v72.4.1134.1134.

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Abstract A culture system that allows human blood monocytes to differentiate into macrophages in vitro was used to study B-cell stimulatory factor- 2/interleukin-6 (interferon-beta 2/26 kd protein) expression in mononuclear phagocytes. Using B-cell stimulatory factor-2 (BSF-2) cDNA and a polyclonal, monospecific antibody directed against human BSF-2, we find that strong interleukin-6 (IL-6) expression is initiated in cultured monocytes on stimulation with endotoxin. Maximally induced monocytic BSF-2/IL-6 synthesis (1% to 2% of total proteins secreted by monocytes) is more than ten times strong

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Bauer, J., U. Ganter, T. Geiger, et al. "Regulation of interleukin-6 expression in cultured human blood monocytes and monocyte-derived macrophages." Blood 72, no. 4 (1988): 1134–40. http://dx.doi.org/10.1182/blood.v72.4.1134.bloodjournal7241134.

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A culture system that allows human blood monocytes to differentiate into macrophages in vitro was used to study B-cell stimulatory factor- 2/interleukin-6 (interferon-beta 2/26 kd protein) expression in mononuclear phagocytes. Using B-cell stimulatory factor-2 (BSF-2) cDNA and a polyclonal, monospecific antibody directed against human BSF-2, we find that strong interleukin-6 (IL-6) expression is initiated in cultured monocytes on stimulation with endotoxin. Maximally induced monocytic BSF-2/IL-6 synthesis (1% to 2% of total proteins secreted by monocytes) is more than ten times stronger than i

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Xiao, L., L. B. Gao, and Q. Wei. "Association of polymorphism within the interleukin-28 receptor alpha gene, but not in interleukin-28B, with lower urinary tract symptoms (LUTS) in Chinese." Genetics and Molecular Research 14, no. 3 (2015): 10682–91. http://dx.doi.org/10.4238/2015.september.9.8.

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Gomon, Yu M., A. S. Kolbin, A. M. Fahrutdinova, T. A. Usmanova, F. M. Sultanova, and Yu E. Balykina. "A Systematic Review with Meta-Analysis and Indirect Comparison of the Effectiveness of COVID-19 Anti-Interleukin Therapy." Antibiotics and Chemotherapy 68, no. 3-4 (2023): 52–65. http://dx.doi.org/10.37489/0235-2990-2023-68-3-4-52-65.

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Aim. Evaluation of the effectiveness of anti-interleukin drugs used in the pathogenetic therapy of COVID-19 in relation to the relative risks of 28-day mortality and the odds ratio of 14-day improvement of symptoms of the disease. Materials and methods. A systematic review of publications concerning the evaluation of the effectiveness of these drugs recommended for use as COVID-19 pathogenetic therapy, with meta-analysis and indirect comparison of the data obtained, was carried out. Results. The meta-analysis included 15 randomized and 8 non-randomized studies. In direct comparison of anti-int

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Kaufmann, Christoph C., Amro Ahmed, Marie Muthspiel, et al. "Association of Interleukin-32 and Interleukin-34 with Cardiovascular Disease and Short-Term Mortality in COVID-19." Journal of Clinical Medicine 12, no. 3 (2023): 975. http://dx.doi.org/10.3390/jcm12030975.

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Background: Excess cardiovascular (CV) morbidity and mortality has been observed in patients with COVID-19. Both interleukin-32 (IL-32) and interleukin-34 (IL-34) have been hypothesized to contribute to CV involvement in COVID-19. Methods: This prospective, observational study of patients with laboratory-confirmed COVID-19 infection was conducted from 6 June to 22 December 2020 in a tertiary care hospital in Vienna, Austria. IL-32 and IL-34 levels on admission were collected and tested for their association with CV disease and short-term mortality in patients with COVID-19. CV disease was defi

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Dedeoglu, B., N. H. R. Litjens, M. Klepper, et al. "CD 4 + CD 28 null T cells are not alloreactive unless stimulated by interleukin ‐15." American Journal of Transplantation 18, no. 2 (2017): 341–50. http://dx.doi.org/10.1111/ajt.14480.

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30

Amiri, F. S. "The relationship between elevated serum levels of soluble interleukin-2 receptor and renal outcomes in hemophagocytic lymphohistiocytosis." Nephrology (Saint-Petersburg) 28, no. 4 (2025): 100–110. https://doi.org/10.36485/1561-6274-2024-28-4-100-110.

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BACKGROUND: Hemophagocytic lymphohistiocytosis is an uncommon disease with a high mortality rate due to ineffective overactivation of the immune system. THE AIM: to assess the effect and prediction of elevated serum soluble interleukin-2 alpha level on kidney outcomes in hemophagocytic lymphohistiocytosis.PATIENTS AND METHODS: In this analytic (experimental) clinical studies type with randomized clinical trials design in meta-analysis article, two-hundred eighty-three patients with hemophagocytosis lymphohistiocytosis diagnosis and kidney impairment were investigated.RESULTS: Relative risk and

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31

Sun, Hanxue, Tiantian Gu, Guoqin Li, et al. "Effects of Compound Probiotics on Growth Performance, Serum Biochemical and Immune Indices, Antioxidant Capacity, and Intestinal Tissue Morphology of Shaoxing Duck." Animals 12, no. 22 (2022): 3219. http://dx.doi.org/10.3390/ani12223219.

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This experiment was conducted to investigate the effects of compound probiotics on growth performance, serum biochemical and immune indices, antioxidant capacity, and the intestinal tissue morphology of Shaoxing ducks. A total of 640 1-day-old healthy Shaoxing ducks of similar body weight were randomly divided into two treatment groups with eight replicates each and forty ducks per replicate. The ducks were fed a basal diet (Ctrl) or a basal diet supplemented with 0.15% compound probiotics (CP) for 125 d. The results revealed that the live body weight (BW; day 85 and 125) and the average daily

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Ahn, Sung-Hoon, Tae-Hwe Heo, Hyun-Sik Jun, and Yongseok Choi. "In vitro and in vivo pharmacokinetic characterization of LMT-28 as a novel small molecular interleukin-6 inhibitor." Asian-Australasian Journal of Animal Sciences 33, no. 4 (2020): 670–77. http://dx.doi.org/10.5713/ajas.19.0463.

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Objective: Interleukin-6 (IL-6) is a T cell-derived B cell stimulating factor which plays an important role in inflammatory diseases. In this study, the pharmacokinetic properties of LMT-28 including physicochemical property, <i>in vitro</i> liver microsomal stability and an <i>in vivo</i> pharmacokinetic study using BALB/c mice were characterized.Methods: LMT-28 has been synthesized and is being developed as a novel therapeutic IL-6 inhibitor. The physicochemical properties and <i>in vitro</i> pharmacokinetic profiles such as liver microsomal stability and

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Elhefnawy, Khaled A., Ahmed M. Salah, and Hanaa H. Elsaid. "The role of interleukin-19 in diabetic nephropathy." Egyptian Journal of Internal Medicine 31, no. 4 (2019): 917–21. http://dx.doi.org/10.4103/ejim.ejim_153_19.

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Abstract Background Proinflammatory cytokines play an important role in the establishment of arteriolosclerosis and kidney injury. Inflammatory cytokines are involved in the development of microvascular diabetic complications, including diabetic nephropathy (DN). Interleukin-19 (IL-19) has vital functions in many inflammatory processes and also can induce the angiogenesis of endothelial cells. Objective To investigate the role of IL-19 in the development of DN. Patients and methods A total of 112 participants were included and classified into four main groups: group I was the control group, wh

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Beaubien, B. C., P. D. Collins, P. J. Jose, et al. "A novel neutrophil chemoattractant generated during an inflammatory reaction in the rabbit peritoneal cavity in vivo. Purification, partial amino acid sequence and structural relationship to interleukin 8." Biochemical Journal 271, no. 3 (1990): 797–801. http://dx.doi.org/10.1042/bj2710797.

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An inflammatory reaction was induced in vivo by injection of zymosan into the peritoneal cavity of the rabbit. The inflammatory exudate was found to contain oedema-inducing and neutrophil chemoattractant activity when assayed in rabbit skin in vivo, using 125I-albumin and 111In-neutrophils. This activity was additional to that of complement fragment C5a, which was removed by an affinity gel. Two chemoattractants were isolated by cation-exchange, gel-filtration and reversed-phase h.p.l.c. One of these, which ran as a single band of 6-8 kDa on SDS/PAGE, was subjected to N-terminal sequence analy

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Sattar Brissm Hassan, Hanaa Naji Abdullah, and Khaled Yassin Zakair. "The role of IL-24 as a pro-inflammatory cytokine in some Iraqi rheumatoid arthritis patients." Journal of the Pakistan Medical Association 73, no. 9 (2023): S98—S101. http://dx.doi.org/10.47391/jpma.iq-21.

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Objective: To determine the role of interleukin-24 as a pro-inflammatory cytokine among female rheumatoid arthritispatients, and its correlation with clinical parameters.Method: The case-control study was conducted from April to July 2021 at the Baghdad Teaching Hospital andYarmouk Teaching Hospital, Iraq, and comprised women aged 26-60 years in the Al-Karkh district having rheumatoidarthritis diagnosed by a rheumatologist, and healthy controls matched for age and gender. Data was analysed usingSPSS 28.Results: Of the 118 subjects, 76(64.4%) were patients with mean age 45.38±1.23 years, and 42

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Zou, Changzhi, Xin Xing, Shunxi Li, Xuelong Zheng, Jinshan Zhao, and Huawei Liu. "Effects of a Combined Chinese Herbal Medicine on Growth Performance, Intestinal Barrier Function, Immune Response, and Cecal Microflora in Broilers Infected with Salmonella enteritidis." Animals 14, no. 18 (2024): 2670. http://dx.doi.org/10.3390/ani14182670.

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This study investigated the effects of CCHM in drinking water on broilers infected with Salmonella enteritidis. One-day-old male Cobb 500 broilers (n = 300) were randomly assigned to five groups: a control (NC) group, a Salmonella enteritidis challenge (SE) group, an antibiotic (AB) group, a low dose of CCHM (CL) group, and a high dose of CCHM (CH) group. Each group had six replicate cages with ten broilers per cage. The broilers in the NC and SE groups were given normal drinking water. From days 12 to 18, the AB group received water treated with ciprofloxacin lactate injection (1 mL/L), while

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Conway, Richard, Lorraine O’Neill, Geraldine M. McCarthy, et al. "Interleukin 12 and interleukin 23 play key pathogenic roles in inflammatory and proliferative pathways in giant cell arteritis." Annals of the Rheumatic Diseases 77, no. 12 (2018): 1815–24. http://dx.doi.org/10.1136/annrheumdis-2018-213488.

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ObjectivesThe pathogenesis of giant cell arteritis (GCA) remains unclear. TH1 and TH17 pathways are implicated, but the proximal initiators and effector cytokines are unknown. Our aim was to assess the role of interleukin 12 (IL-12) and interleukin 23 (IL-23) in GCA pathogenesis.MethodsIL-12 and IL-23 expression were quantified by immunohistochemistry in temporal artery biopsies (TABs). Temporal artery (TA) explant, peripheral blood mononuclear cell (PBMC) and myofibroblast outgrowth culture models were established. PBMCs and TA explants were cultured for 24 hours in the presence or absence of

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Quesniaux, VF, S. Wehrli, C. Steiner, et al. "The immunosuppressant rapamycin blocks in vitro responses to hematopoietic cytokines and inhibits recovering but not steady-state hematopoiesis in vivo." Blood 84, no. 5 (1994): 1543–52. http://dx.doi.org/10.1182/blood.v84.5.1543.1543.

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Abstract The immunosuppressive drug rapamycin suppresses T-cell activation by impairing the T-cell response to lymphokines such as interleukin-2 (IL- 2) and interleukin-4 (IL-4). In addition, rapamycin blocks the proliferative response of cell lines to a variety of hematopoietic growth factors, including interleukin-3 (IL-3), interleukin-6 (IL-6), granulocyte-colony stimulating factor (G-CSF), granulocyte macrophage- colony stimulating factor (GM-CSF), and kit ligand (KL), suggesting that it should be a strong inhibitor of hematopoiesis. In this report, we studied the effects of rapamycin on d

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Quesniaux, VF, S. Wehrli, C. Steiner, et al. "The immunosuppressant rapamycin blocks in vitro responses to hematopoietic cytokines and inhibits recovering but not steady-state hematopoiesis in vivo." Blood 84, no. 5 (1994): 1543–52. http://dx.doi.org/10.1182/blood.v84.5.1543.bloodjournal8451543.

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The immunosuppressive drug rapamycin suppresses T-cell activation by impairing the T-cell response to lymphokines such as interleukin-2 (IL- 2) and interleukin-4 (IL-4). In addition, rapamycin blocks the proliferative response of cell lines to a variety of hematopoietic growth factors, including interleukin-3 (IL-3), interleukin-6 (IL-6), granulocyte-colony stimulating factor (G-CSF), granulocyte macrophage- colony stimulating factor (GM-CSF), and kit ligand (KL), suggesting that it should be a strong inhibitor of hematopoiesis. In this report, we studied the effects of rapamycin on different

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Robinson, Prema, Pablo C. Okhuysen, Cynthia L. Chappell та ін. "Expression of Tumor Necrosis Factor Alpha and Interleukin 1β in Jejuna of Volunteers after Experimental Challenge withCryptosporidium parvum Correlates with Exposure but Not with Symptoms". Infection and Immunity 69, № 2 (2001): 1172–74. http://dx.doi.org/10.1128/iai.69.2.1172-1174.2001.

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ABSTRACT Jejunal biopsies from volunteers challenged withCryptosporidium parvum were examined for tumor necrosis factor alpha (TNF-α) and interleukin (IL)-1β mRNA. Postchallenge biopsies from 15 of 28 (54%) volunteers expressed TNF-α; 14% expressed IL-1β. Cytokine expression did not correlate with enteric symptoms, suggesting that TNF-α and IL-1β are not key mediators of diarrhea in human cryptosporidiosis.

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Hardie, William D., Daniel R. Prows, George D. Leikauf та Thomas R. Korfhagen. "Attenuation of acute lung injury in transgenic mice expressing human transforming growth factor-α". American Journal of Physiology-Lung Cellular and Molecular Physiology 277, № 5 (1999): L1045—L1050. http://dx.doi.org/10.1152/ajplung.1999.277.5.l1045.

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Transforming growth factor-α (TGF-α) is produced in the lung in experimental and human lung diseases; however, its physiological actions after lung injury are not understood. To determine the influence of TGF-α on acute lung injury, transgenic mouse lines expressing differing levels of human TGF-α in distal pulmonary epithelial cells under control of the surfactant protein C gene promoter were generated. TGF-α transgenic and nontransgenic control mice were exposed to polytetrafluoroethylene (PTFE; Teflon) fumes to induce acute lung injury. Length of survival of four separate TGF-α transgenic m

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Österlund, Pamela, Ville Veckman, Jukka Sirén, et al. "Gene Expression and Antiviral Activity of Alpha/Beta Interferons and Interleukin-29 in Virus-Infected Human Myeloid Dendritic Cells." Journal of Virology 79, no. 15 (2005): 9608–17. http://dx.doi.org/10.1128/jvi.79.15.9608-9617.2005.

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ABSTRACT Dendritic cells (DCs) respond to microbial infections by undergoing phenotypic maturation and by producing multiple cytokines. In the present study, we analyzed the ability of influenza A and Sendai viruses to induce DC maturation and activate tumor necrosis factor alpha (TNF-α), alpha/beta interferon (IFN-α/β), and IFN-like interleukin-28A/B (IFN-λ2/3) and IL-29 (IFN-λ1) gene expression in human monocyte-derived myeloid DCs (mDC). The ability of influenza A virus to induce mDC maturation or enhance the expression of TNF-α, IFN-α/β, interleukin-28 (IL-28), and IL-29 genes was limited,

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Martirosyan, Danik, Mohammad Reza Ashoori, Afsaneh Seyed Mikaeili, et al. "Inflammatory factors and immunoglobulins alterations in subjects with type 2 diabetes mellitus treated with squalene." Functional Food Science 2, no. 8 (2022): 181. http://dx.doi.org/10.31989/ffs.v2i8.979.

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Background: Squalene is a 30-carbon (as a polyunsaturated triterpene) compound that has been suggested to have several benefits. In recent years, its anti-diabetic, anti-inflammatory and antioxidant effects have been studied.Objective: The aim of this study was to investigate the effect of different doses of squalene on different days on the changes in the levels of inflammatory cytokines and antibodies in people with type 2 diabetes and then compare it.Methods: In this study, 4 groups with type 2 diabetes mellitus and 1 control group were selected. 4 groups with type 2 diabetes mellitus were

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Lin, Sunny Jui-Shan, Yung-Yen Cheng, Chih-Hung Chang, Cheng-Hung Lee, Yi-Chia Huang, and Yi-Chang Su. "Traditional Chinese Medicine Diagnosis “Yang-Xu Zheng”: Significant Prognostic Predictor for Patients with Severe Sepsis and Septic Shock." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/759748.

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Pathogenesis of sepsis includes complex interaction between pathogen activities and host response, manifesting highly variable signs and symptoms, possibly delaying diagnosis and timely life-saving interventions. This study applies traditional Chinese medicine (TCM)Zhengdiagnosis in patients with severe sepsis and septic shock to evaluate its adaptability and use as an early predictor of sepsis mortality. Three-year prospective observational study enrolled 126 septic patients. TCMZhengdiagnosis, Acute Physiology and Chronic Health Evaluation (APACHE) II score, and blood samples for host respon

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Arnott, I. D. R., H. E. Drummond, and S. Ghosh. "Frequency of Continuing Mucosal Inflammation in Clinically Inactive Crohn's Disease." Scottish Medical Journal 46, no. 5 (2001): 136–39. http://dx.doi.org/10.1177/003693300104600504.

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The treatment goal in Crohn's disease is clinical remission, not complete mucosal healing. The incidence of mucosal inflammation in Crohn's disease patients in clinical remission is not known. Whole gut lavage is an objective method of assessing mucosal inflammation. We aimed to assess levels of mucosal inflammatory activity in a group of patients with clinically inactive Crohn's disease. We prospectively assessed 30 patients with inactive Crohn's disease and 28 controls. Inactive disease was defined as Crohn's disease activity index of less than 150. All underwent whole put lavage, with analy

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Galimova, E. S., and E. K. Khusnutdinova. "INTERLEUKIN 28 RECEPTOR GENE ALPHA IL28RA AND PSORIASIS: ASSOCIATION WITH DISEASE SEVERITY AND AGE AT ONSET." Medical Immunology (Russia) 17, no. 6 (2016): 567–72. http://dx.doi.org/10.15789/1563-0625-2015-6-567-572.

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Simili, Angelo, Giuseppe Mazzella, Federico Ravaioli, et al. "Interleukin 28 Polymorphisms and Hepatocellular Carcinoma Development after Direct Acting Antiviral Therapy for Chronic Hepatitis C." Journal of Gastrointestinal and Liver Diseases 28, no. 4 (2019): 449–56. http://dx.doi.org/10.15403/jgld-309.

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Background and Aims: Cirrhotic patients with hepatitis C virus (HCV) infection remain at risk of developing hepatocellular carcinoma (HCC) even after the sustained virologic response (SVR). We aimed to evaluate whether the IL28 (rs12979860) single nucleotide polymorphism (SNP) may constitute a predisposing genetic factor and to identify the SVR patients at risk of HCC. Methods: Two hundred patients undergoing DAAs treatment for chronic hepatitis C with advanced fibrosis (F3- F4) were consecutively enrolled. Besides normal routine laboratory testing for HCV, patients’ sera were evaluated

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Simmons, Julie, Adrienne Woodward, Hang Lu, and Nathan Horn. "PSXIV-28 Post-Confluence Cell Age Affects Lipopolysaccharide-Induced Interleukin-8 Secretion in Ipec-J2 Cells." Journal of Animal Science 101, Supplement_3 (2023): 540. http://dx.doi.org/10.1093/jas/skad281.635.

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Abstract Porcine intestinal epithelial cell line IPEC-J2 is routinely used to investigate epithelial cell interactions with common enteric porcine antigens and pathogens. Lipopolysaccharides (LPS) are bacterial antigens metabolized from Gram negative bacteria that can induce a cellular inflammatory cascade, resulting in changes to cell structure and integrity, and are often used to challenge IPEC-J2 cells. Although numerous investigators employ the IPEC-J2 LPS model, consistent methodology regarding cell culture conditions and treatment times is not well defined. The objective of the current s

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Deehan, D. J., S. D. Heys, J. Broom, O. Eremin, and P. H. Whiting. "Renal Impairment Associated with the Pre-Operative Administration of Recombinant Interleukin-2." Clinical Science 87, no. 5 (1994): 513–18. http://dx.doi.org/10.1042/cs0870513.

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1. The T-cell-derived cytokine interleukin-2 may be used to reverse the immune suppression associated with major surgery. However, both major surgical procedures and recombinant interleukin-2 therapy are known to induce renal dysfunction. 2. Eighteen patients were randomized to receive either recombinant interleukin-2 (18 × 106 i.u./day) or placebo, given subcutaneously for 3 days before undergoing curative colorectal cancer surgery. Indices of renal function were determined pre-operatively and for 21 days after surgery. 3. Pre-operative recombinant interleukin-2 was found to significantly inc

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M. Ali, Basim, Furqan Moein, Maha Al-Andaleb, and Shaymaa Dhyaa. "A field study dealing with biocmetrics of some clinical variables for hepatitis C patients." Al-Kufa University Journal for Biology 13, no. 2 (2021): 32–38. http://dx.doi.org/10.36320/ajb/v13.i2.11757.

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Hepatitis C virus is one of the most dangerous and contagious diseases, as its danger lies in the absence of obvious symptoms at the beginning of the infection. Over time, some signs may appear, such as yellowing of the skin , eyes and abdominal pain, but in advanced cases, it may lead to cirrhosis of the liver and may lead to death. The current study aims to know the extent of liver damage to infection with the virus by measuring some biochemical variables such as direct, indirect and total bilirubin, and on the other hand, measuring interleukin-28b to determine the extent of the immune respo

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