Journal articles: 'Interleukin-6'

1

&NA;. "Interleukin-3/interleukin-6." Reactions Weekly &NA;, no. 550 (May 1995): 11. http://dx.doi.org/10.2165/00128415-199505500-00035.

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&NA;. "Interleukin-6." Reactions Weekly &NA;, no. 570 (September 1995): 9. http://dx.doi.org/10.2165/00128415-199505700-00023.

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Lotz, Martin. "Interleukin-6." Cancer Investigation 11, no. 6 (January 1993): 732–42. http://dx.doi.org/10.3109/07357909309046948.

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&NA;. "Interleukin 6." Inpharma Weekly &NA;, no. 877 (March 1993): 2. http://dx.doi.org/10.2165/00128413-199308770-00001.

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&NA;. "Interleukin 6." Reactions Weekly &NA;, no. 505 (June 1994): 8. http://dx.doi.org/10.2165/00128415-199405050-00037.

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&NA;. "Interleukin 6." Reactions Weekly &NA;, no. 531 (December 1994): 8. http://dx.doi.org/10.2165/00128415-199405310-00027.

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Song, Mingchen, and John A. Kellum. "Interleukin-6." Critical Care Medicine 33, Suppl (December 2005): S463—S465. http://dx.doi.org/10.1097/01.ccm.0000186784.62662.a1.

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CASTELL, JOSé V., TILO ANDUS, DIETER KUNZ, and PETER C. HEINRICH. "Interleukin-6." Annals of the New York Academy of Sciences 557, no. 1 (June 28, 2008): 87–101. http://dx.doi.org/10.1111/j.1749-6632.1989.tb24001.x.

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LEE, FRANK, CHOY-PIK CHIU, JANUSZ WIDEMAN, PHILLIP HODGKIN, SUSAN HUDAK, LOUISE TROUTT, THERESA NG, et al. "Interleukin-6." Annals of the New York Academy of Sciences 557, no. 1 (June 28, 2008): 215–29. http://dx.doi.org/10.1111/j.1749-6632.1989.tb24015.x.

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CLARK, STEVEN C. "Interleukin-6." Annals of the New York Academy of Sciences 557, no. 1 (June 28, 2008): 438–43. http://dx.doi.org/10.1111/j.1749-6632.1989.tb24036.x.

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Olencki, Thomas, James Finke, and Ronald M. Bukowski. "Interleukin-6." Clinical Immunotherapeutics 2, no. 4 (October 1994): 278–94. http://dx.doi.org/10.1007/bf03258528.

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Sin, Don D., and S. F. Paul Man. "Interleukin-6." Chest 133, no. 1 (January 2008): 4–6. http://dx.doi.org/10.1378/chest.07-2085.

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13

Delk, Nikki A., and Mary C. Farach-Carson. "Interleukin-6." Autophagy 8, no. 4 (April 2012): 650–63. http://dx.doi.org/10.4161/auto.19226.

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14

Matsuda, Tadashi, and Toshio Hirano. "Interleukin 6 (IL-6)." Biotherapy 2, no. 4 (October 1990): 363–73. http://dx.doi.org/10.1007/bf02170085.

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15

Rivera-Chavez, Fernando A., Dixie L. Peters-Hybki, Robert C. Barber, and Grant E. O'Keefe. "Interleukin-6 Promoter Haplotypes and Interleukin-6 Cytokine Responses." Shock 20, no. 3 (September 2003): 218–23. http://dx.doi.org/10.1097/00024382-200309000-00004.

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16

Ridker, Paul M. "Targeting Interleukin-1 and Interleukin-6." Journal of the American College of Cardiology 76, no. 15 (October 2020): 1774–76. http://dx.doi.org/10.1016/j.jacc.2020.08.052.

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NORTHEMANN, WOLFGANG, TODD A. BFUCIAK, MASAHIRA HATTORI, and GEORG H. FEY. "Rat Interleukin-6." Annals of the New York Academy of Sciences 557, no. 1 (June 28, 2008): 536–39. http://dx.doi.org/10.1111/j.1749-6632.1989.tb24057.x.

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18

Schneider, Kirsten, Reinhard Klaas, Bernd Kaspers, and Peter Staeheli. "Chicken interleukin-6." European Journal of Biochemistry 268, no. 15 (August 1, 2001): 4200–4206. http://dx.doi.org/10.1046/j.1432-1327.2001.02334.x.

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Tamura, T., N. Udagawa, N. Takahashi, C. Miyaura, S. Tanaka, Y. Yamada, Y. Koishihara, Y. Ohsugi, K. Kumaki, and T. Taga. "Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6." Proceedings of the National Academy of Sciences 90, no. 24 (December 15, 1993): 11924–28. http://dx.doi.org/10.1073/pnas.90.24.11924.

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Ogawa, Michio, Kiyoshi Sakamoto, Seiji Mita, Takatoshi Ishiko, and Saburo Hisano. "INTERLEUKIN-6 AND SOLUBLE INTERLEUKIN-6 RECEPTOR IN SURGICAL TRAUMA." Shock 4, Supplement (December 1995): 11. http://dx.doi.org/10.1097/00024382-199512001-00045.

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21

De Filippo, G., D. Rendina, F. Moccia, V. Rocco, and A. Campanozzi. "Interleukin-6, soluble interleukin-6 receptor/interleukin-6 complex and insulin resistance in obese children and adolescents." Journal of Endocrinological Investigation 38, no. 3 (September 23, 2014): 339–43. http://dx.doi.org/10.1007/s40618-014-0176-4.

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22

Oka, Masaaki, Hiroshi Kusanagi, Toshihiro Saeki, Norio Iizuka, Hiroto Hayashi, Akira Tangoku, Takuo Murakami, and Takashi Suzuki. "Interleukin-6 Production and Interleukin-6 Receptor Expression in Human Esophageal Cancer Cell Lines." Japanese Journal of Gastroenterological Surgery 26, no. 11 (1993): 2707. http://dx.doi.org/10.5833/jjgs.26.2707.

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23

Prens, Errol P., Klazina Benne, Jozef van Damme, Marleen Bakkus, Karin Brakel, Robbert Benner, and Theodoor van Joost. "Interleukin-1 and Interleukin-6 in Psoriasis." Journal of Investigative Dermatology 95, no. 6 (December 1990): S121—S124. http://dx.doi.org/10.1111/1523-1747.ep12874991.

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24

Bota, Rafaqat, and Mushtaq Ahmed. "The pathophysiological profile of interleukin-6 and anti-interleukin-6 antibody." El Mednifico Journal 1, no. 2 (July 6, 2013): 51. http://dx.doi.org/10.18035/emj.v1i2.26.

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25

Ridker, Paul M., and Manas Rane. "Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease." Circulation Research 128, no. 11 (May 28, 2021): 1728–46. http://dx.doi.org/10.1161/circresaha.121.319077.

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Abstract:

IL (interleukin)-6 is a pivotal cytokine of innate immunity, which enacts a broad set of physiological functions traditionally associated with host defense, immune cell regulation, proliferation, and differentiation. Following recognition of innate immune pathways leading from the NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome to IL-1 to IL-6 and on to the hepatically derived clinical biomarker CRP (C-reactive protein), an expanding literature has led to understanding of the proatherogenic role for IL-6 in cardiovascular disease and thus the potential for IL-6 inhibition as a novel method for vascular protection. In this review, we provide an overview of the mechanisms by which IL-6 signaling occurs and how that impacts upon pharmacological inhibition; describe murine models of IL-6 and atherogenesis; summarize human epidemiological data outlining the utility of IL-6 as a biomarker of vascular risk; outline genetic data suggesting a causal role for IL-6 in systemic atherothrombosis and aneurysm formation; and then detail the potential role of IL-6 inhibition in stable coronary disease, acute coronary syndromes, heart failure, and the atherothrombotic complications associated with chronic kidney disease and end-stage renal failure. Finally, we review anti-inflammatory and antithrombotic findings for ziltivekimab, a novel IL-6 ligand inhibitor being developed specifically for use in atherosclerotic disease and poised to be tested formally in a large-scale cardiovascular outcomes trial focused on individuals with chronic kidney disease and elevated levels of CRP, a population at high residual atherothrombotic risk, high residual inflammatory risk, and considerable unmet clinical need.

26

Jucker, M., H. Abts, W. Li, R. Schindler, H. Merz, A. Gunther, C. von Kalle, M. Schaadt, T. Diamantstein, and AC Feller. "Expression of interleukin-6 and interleukin-6 receptor in Hodgkin's disease." Blood 77, no. 11 (June 1, 1991): 2413–18. http://dx.doi.org/10.1182/blood.v77.11.2413.2413.

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Abstract:

Abstract Interleukin-6 (IL-6) is a multipotent lymphokine that can mediate differentiation of B cells into Ig-secreting cells, stimulate the growth of plasmacytomas, hybridomas, and T cells, and induce acute- phase proteins in liver cells. It has been suggested that IL-6 is involved in the pathogenesis of several diseases by autocrine or paracrine pathways. To examine whether IL-6 is possibly involved in the pathophysiology of Hodgkin's disease (HD), we analyzed the expression of IL-6 and IL-6 receptor mRNA and protein in cell lines and primary specimens from patients with HD. IL-6-specific transcripts were detected in three of six HD-derived cell lines by Northern blot analysis. In the culture supernatants of four HD-derived cell lines, IL- 6 was detected by radioimmunoassay. Biologic activity of IL-6 was confirmed by proliferation of an IL-6-dependent cell line. In situ hybridization experiments showed IL-6-specific transcripts in Hodgkin (H) and Reed-Sternberg (RS) cells in primary tissues of two patients. In addition, mRNAs specific for the IL-6 receptor were detected in five HD-derived cell lines. Immunostaining experiments showed expression of IL-6 receptor molecules on H and RS cells in 8 of 16 cases with HD. Thus, our data suggest that IL-6 might be involved in the pathophysiology of HD.

27

Jucker, M., H. Abts, W. Li, R. Schindler, H. Merz, A. Gunther, C. von Kalle, M. Schaadt, T. Diamantstein, and AC Feller. "Expression of interleukin-6 and interleukin-6 receptor in Hodgkin's disease." Blood 77, no. 11 (June 1, 1991): 2413–18. http://dx.doi.org/10.1182/blood.v77.11.2413.bloodjournal77112413.

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Abstract:

Interleukin-6 (IL-6) is a multipotent lymphokine that can mediate differentiation of B cells into Ig-secreting cells, stimulate the growth of plasmacytomas, hybridomas, and T cells, and induce acute- phase proteins in liver cells. It has been suggested that IL-6 is involved in the pathogenesis of several diseases by autocrine or paracrine pathways. To examine whether IL-6 is possibly involved in the pathophysiology of Hodgkin's disease (HD), we analyzed the expression of IL-6 and IL-6 receptor mRNA and protein in cell lines and primary specimens from patients with HD. IL-6-specific transcripts were detected in three of six HD-derived cell lines by Northern blot analysis. In the culture supernatants of four HD-derived cell lines, IL- 6 was detected by radioimmunoassay. Biologic activity of IL-6 was confirmed by proliferation of an IL-6-dependent cell line. In situ hybridization experiments showed IL-6-specific transcripts in Hodgkin (H) and Reed-Sternberg (RS) cells in primary tissues of two patients. In addition, mRNAs specific for the IL-6 receptor were detected in five HD-derived cell lines. Immunostaining experiments showed expression of IL-6 receptor molecules on H and RS cells in 8 of 16 cases with HD. Thus, our data suggest that IL-6 might be involved in the pathophysiology of HD.

28

Plenz, Gabriele, Heike Eschert, Michael Erren, Thomas Wichter, Michael Böhm, Markus Flesch, Hans H. Scheld, and Mario C. Deng. "The interleukin-6/interleukin-6-receptorsystem is activated in donor hearts." Journal of the American College of Cardiology 39, no. 9 (May 2002): 1508–12. http://dx.doi.org/10.1016/s0735-1097(02)01791-6.

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29

Nancey, Stéphane, Nadim Hamzaoui, Driffa Moussata, Ivan Graber, Jacques Bienvenu, and Bernard Flourie. "Serum Interleukin-6, Soluble Interleukin-6 Receptor and Crohn’s Disease Activity." Digestive Diseases and Sciences 53, no. 1 (June 5, 2007): 242–47. http://dx.doi.org/10.1007/s10620-007-9849-6.

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30

Angelis, Pela, Simon Scharf, Alastair Mander, Frank Vajda, and Nicholas Christophidis. "Serum interleukin-6 and interleukin-6 soluble receptor in Alzheimer's disease." Neuroscience Letters 244, no. 2 (March 1998): 106–8. http://dx.doi.org/10.1016/s0304-3940(98)00136-0.

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31

Rezai, Ali R., Ahmad Rezai, Otoniel Mart�nez-Maza, Meta Vander-Meyden, and Martin H. Weiss. "Interleukin-6 and interleukin-6 receptor gene expression in pituitary tumors." Journal of Neuro-Oncology 19, no. 2 (June 1994): 131–35. http://dx.doi.org/10.1007/bf01306454.

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32

MONTERO-JULIAN, F. A., E. GAUTHEROT, J. WIJDENES, B. KLEIN, and H. BRAILLY. "Pharmacokinetics of Interleukin-6 During Therapy with Anti-Interleukin-6 Monoclonal Antibodies: Enhanced Clearance of Interleukin-6 by a Combination of Three Anti-Interleukin-6 Antibodies." Journal of Interferon Research 14, no. 5 (October 1994): 301–2. http://dx.doi.org/10.1089/jir.1994.14.301.

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33

KENIS, G., C. TEUNISSEN, R. DEJONGH, E. BOSMANS, H. STEINBUSCH, and M. MAES. "STABILITY OF INTERLEUKIN 6, SOLUBLE INTERLEUKIN 6 RECEPTOR, INTERLEUKIN 10 AND CC16 IN HUMAN SERUM." Cytokine 19, no. 5 (September 2002): 228–35. http://dx.doi.org/10.1016/s1043-4666(02)91961-7.

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34

Kenis, Gunter, Charlotte Teunissen, Raf De Jongh, Eugène Bosmans, Harry Steinbusch, and Michael Maes. "STABILITY OF INTERLEUKIN 6, SOLUBLE INTERLEUKIN 6 RECEPTOR, INTERLEUKIN 10 AND CC16 IN HUMAN SERUM." Cytokine 19, no. 5 (September 2002): 228–35. http://dx.doi.org/10.1006/cyto.2002.1961.

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35

HIRANO, TOSHIO. "Interleukin 6 (IL-6) and disease." Japanese Journal of Clinical Immunology 13, no. 5 (1990): 444–45. http://dx.doi.org/10.2177/jsci.13.444.

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36

Van Wagoner, N. J., and E. N. Benveniste. "Interleukin-6 regulation in human astrocytes: Synergy between TNF-alpha, interleukin-6, and the soluble-interleukin-6 receptor-alpha." Journal of Neuroimmunology 90, no. 1 (September 1998): 53. http://dx.doi.org/10.1016/s0165-5728(98)91497-7.

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37

Hoejberg, Lise, Lars Bastholt, and Henrik Schmidt. "Interleukin-6 and melanoma." Melanoma Research 22, no. 5 (October 2012): 327–33. http://dx.doi.org/10.1097/cmr.0b013e3283543d72.

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38

Rose-John, Stefan. "Interleukin-6 Family Cytokines." Cold Spring Harbor Perspectives in Biology 10, no. 2 (June 15, 2017): a028415. http://dx.doi.org/10.1101/cshperspect.a028415.

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39

Tanaka, Toshio, Masashi Narazaki, and Tadamitsu Kishimoto. "Interleukin (IL-6) Immunotherapy." Cold Spring Harbor Perspectives in Biology 10, no. 8 (August 4, 2017): a028456. http://dx.doi.org/10.1101/cshperspect.a028456.

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40

Suzuki, Kenshi, Akiko Miyashita, Yasuyuki Inoue, Seiko Iki, Hidetoshi Enomoto, Yuji Takahashi, and Tamiko Takemura. "Interleukin-6-Producing Pheochromocytoma." Acta Haematologica 85, no. 4 (1991): 217–19. http://dx.doi.org/10.1159/000204897.

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41

Kerr, Ron, David Stirling, and Christopher A. Ludlam. "Interleukin 6 and Haemostasis." British Journal of Haematology 115, no. 1 (October 2001): 3–12. http://dx.doi.org/10.1046/j.1365-2141.2001.03061.x.

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42

Sehgal, Pravinkumar B. "Interleukin-6: Molecular Pathophysiology." Journal of Investigative Dermatology 94, no. 6 (June 1990): s2—s6. http://dx.doi.org/10.1111/1523-1747.ep12874963.

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43

Van Snick, Jacques. "Interleukin-6: An Overview." Annual Review of Immunology 8, no. 1 (April 1990): 253–78. http://dx.doi.org/10.1146/annurev.iy.08.040190.001345.

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44

Pedersen, Bente Klarlund, Adam Steensberg, and Peter Schjerling. "Exercise and interleukin-6." Current Opinion in Hematology 8, no. 3 (May 2001): 137–41. http://dx.doi.org/10.1097/00062752-200105000-00002.

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45

Patarca, Roberto, and Mary Ann Fletcher. "Interleukin-6 and Disease." Journal of Chronic Fatigue Syndrome 4, no. 1 (January 1998): 53–69. http://dx.doi.org/10.1300/j092v04n01_07.

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46

SEHGAL, PRAVIN B., LING WANG, RAVI RAYANADE, HENG PAN, and LOLA MARGULIES. "Interleukin-6-Type Cytokinesa." Annals of the New York Academy of Sciences 762, no. 1 (December 17, 2006): 1–14. http://dx.doi.org/10.1111/j.1749-6632.1995.tb32309.x.

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47

Mehra, Reena. "Soluble Interleukin 6 Receptor." Archives of Internal Medicine 166, no. 16 (September 18, 2006): 1725. http://dx.doi.org/10.1001/archinte.166.16.1725.

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48

Henkin, Robert I., Loren Schmidt, and Irina Velicu. "Interleukin 6 in Hyposmia." JAMA Otolaryngology–Head & Neck Surgery 139, no. 7 (July 1, 2013): 728. http://dx.doi.org/10.1001/jamaoto.2013.3392.

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49

Tesch, H., M. Jüjcler, S. Klein, H. Abts, A. Güjnther, G. R. F. Krueger, and V. Diehl. "Hodgkin and Reed-Sternberg Cells Express Interleukin 6 and Interleukin 6 Receptors." Leukemia & Lymphoma 7, no. 4 (January 1992): 297–303. http://dx.doi.org/10.3109/10428199209049781.

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50

Peters, Malte, Guido Blinn, Thomas Jostock, Peter Schirmacher, Karl–Hermann Meyer Zum Büschenfelde, Peter R. Galle, and Stefan Rose–John. "Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration." Gastroenterology 119, no. 6 (December 2000): 1663–71. http://dx.doi.org/10.1053/gast.2000.20236.

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Journal articles on the topic 'Interleukin-6'

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