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Journal articles on the topic 'Interleuknis'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Kubick, Norwin, Pavel Klimovich, Patrick Henckell Flournoy, et al. "Interleukins and Interleukin Receptors Evolutionary History and Origin in Relation to CD4+ T Cell Evolution." Genes 12, no. 6 (2021): 813. http://dx.doi.org/10.3390/genes12060813.

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Understanding the evolution of interleukins and interleukin receptors is essential to control the function of CD4+ T cells in various pathologies. Numerous aspects of CD4+ T cells’ presence are controlled by interleukins including differentiation, proliferation, and plasticity. CD4+ T cells have emerged during the divergence of jawed vertebrates. However, little is known about the evolution of interleukins and their origin. We traced the evolution of interleukins and their receptors from Placozoa to primates. We performed phylogenetic analysis, ancestral reconstruction, HH search, and positive

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Muderris, T. K., F. Gul, A. Doblan, M. Ergin, and T. Muderris. "Role of T-helper 17 cell related cytokines in laryngeal cancer." Journal of Laryngology & Otology 133, no. 05 (2019): 394–98. http://dx.doi.org/10.1017/s0022215119000689.

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AbstractObjectiveTo explore the role of T-helper 17 cells and their cascade in the pathogenesis of laryngeal cancer.MethodsProspectively, 110 consecutive patients with a suspicious laryngeal lesion were evaluated for serum levels of T-helper 17 cell related interleukins, including interleukins 23, 17A and 22, determined by enzyme-linked immunosorbent assay. The patients were divided into 2 groups after pathological evaluation: 49 patients with malignancy and 61 with benign pathology. Associations between interleukin levels and malignancy were determined via correlation analyses.ResultsInterleu

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Oleksandr, Hruzevskyi. "The cytokine system's status in bacterial dysbiosis and bacterial vaginosis." ScienceRise: Medical Science, no. 3(36) (May 31, 2020): 50–56. https://doi.org/10.15587/2519-4798.2020.204094.

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Interrelations of conditionally-pathogenic microflora and vaginal mucosa’s APC are realized by forming of proinflammatory and regulatory cytokines which can provoke bacterial dysbiosis progression and bacterial vaginosis development. <strong>The a</strong><strong>im of the study: </strong>to determine cytokine system’s status in the blood and vaginal fluid in bacterial dysbiosis and bacterial vaginosis. <strong>Material and methods</strong>. There were used data from 298 women, divided into groups according to the index of conditionally pathogenic microflora and normobiota ind

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FA, Mohamed. "Association of Interleukin 6 (IL6) and 8(IL8) among Women with Spontaneous Abortion in Khartoum State 2018." Virology & Immunology Journal 4, no. 1 (2020): 1–5. http://dx.doi.org/10.23880/vij-16000239.

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Background: Interleukin 6 and Inetrleukin 8 are secreted by macrophage and have been shown to exert deleterious effects on pregnancy, inhibiting fetal growth and development. Possible immunologic causes of spontaneous miscarriages have been extensively researched. The change in the cytokines balance synthesis in favor of those synthesized by macrophage cells with an increase of interleukin 6 and interleukin8 secretion is considered essential for maintaining a normal pregnancy. Aim: To determine the level of cytokines (interleukin6 and interleukin8 ) in pregnant and aborted women to assess the

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Masood, Aetsam, Mahmood Kayani, and Sajida Batool. "Targetting Interleukins Involved in Glioblastoma – A New Pharmacological Approach." Journal of Life and Bio Sciences Research 1, no. 3 (2020): 82–88. http://dx.doi.org/10.38094/jlbsr1330.

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Brain tumor is unchecked growth of brain cells disrupting many of its important functions and, affecting molecular regulatory and signaling networks. Glioblastoma is one of the most deleterious tumors of human brain. Cytokines are secondary messenger molecules in many of the immunological and other biochemical reactions. With glioblastoma progression, various cytokines are secreted that either up-regulate or down-regulate many others with immunological function. Interleukins are a family of cytokines acting mainly as immune-regulatory proteins. They have been implicated in brain tumor initiati

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Huang, Miao, Long Wang, Qianhui Zhang, et al. "Interleukins in Platelet Biology: Unraveling the Complex Regulatory Network." Pharmaceuticals 17, no. 1 (2024): 109. http://dx.doi.org/10.3390/ph17010109.

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Interleukins, a diverse family of cytokines produced by various cells, play crucial roles in immune responses, immunoregulation, and a wide range of physiological and pathological processes. In the context of megakaryopoiesis, thrombopoiesis, and platelet function, interleukins have emerged as key regulators, exerting significant influence on the development, maturation, and activity of megakaryocytes (MKs) and platelets. While the therapeutic potential of interleukins in platelet-related diseases has been recognized for decades, their clinical application has been hindered by limitations in b

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Yablokov, Maxim M., and Maxim M. Yablokov. "Features of senile asthenia syndrome and systemic interleukin profile in elderly patients with combined glaucoma and cataract." Consilium Medicum 22, no. 12 (2020): 81–83. http://dx.doi.org/10.26442/20751753.2020.12.200499.

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The syndrome of senile asthenia in elderly patients with combined glaucoma and cataracts on the background of interleukin imbalance has not been practically studied. Aim. To study the features of senile asthenia syndrome and systemic interleukin profile in elderly patients with combined glaucoma and cataract. Materials and methods. In clinical conditions, the senile asthenia syndrome was studied in 220 patients aged 60–74 years with primary glaucoma combined with cataract, using the questionnaire "Age is not a hindrance". The content of interleukins was determined in the blood by flow cytometr

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Chen, Huihuang, Haibin Lin, and Jianhui Dai. "Causal associations of interleukins and osteoporosis: A genetic correlation study." Medicine 103, no. 32 (2024): e39036. http://dx.doi.org/10.1097/md.0000000000039036.

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The association between interleukins and osteoporosis has attracted much attention these days. However, the causal relationship between them is uncertain. Hence, this study performed a Mendelian randomization (MR) analysis to investigate the causal effects of interleukins on osteoporosis. The summary data for interleukins and osteoporosis came from 4 different genome-wide association studies. Significant and independent (P < 5 × 10−6; r 2 < 0.001, 10,000 kbp) single-nucleotide polymorphisms were extracted for MR analysis. The inverse-variance weighted and other methods were used for MR a

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Chukhraiev, A. M., N. M. Agarkov, D. A. Konyaev, E. V. Popova, M. M. Yablokov, and A. S. Kulabukhov. "Infiornativity lacrimal fluid interleukins in diagnostics and development of angle-closure glaucoma in elderly subjects." Russian Journal of Infection and Immunity 10, no. 4 (2020): 755–61. http://dx.doi.org/10.15789/2220-7619-iit-1247.

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An increased percentage of the elderly subjects in pattern of contemporary society, along with other causes and risk factors, is accompanied by rise in the incidence of glaucoma. By 2020, according to international studies it is expected that prevalence of glaucoma patients in the world would increase up to 80 million subjects. Among the elderly, glaucoma is a common pathology, which development is associated with local disturbances in interleukin profile. However, the features of the latter in patients with primary closed-angle glaucoma in the elderly were poorly examined. Studies of local in

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Al-Obaidi, Manal Taha, Enas Thamer та Qais Ahmed Ibraheem. "Interleukin-1β, 27 Level in Stimulated and Non-stimulated PCOS Infertile Women (Cross-Sectional Study)". Open Access Macedonian Journal of Medical Sciences 10, B (2022): 1555–59. http://dx.doi.org/10.3889/oamjms.2022.9973.

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Background: Polycystic ovary syndrome (PCOS) stands for highly prevalent female endocrine pathology. Females suffering from PCOS have a significantly higher number of inflammatory markers. The IL-1 family members enormously affect the innate immune system. Objectives: Study the changes in the levels of Interleukin- 1ß and Interleukin- 27 in the stimulated and non-stimulated cycle (by gonadotrophin) in polycystic ovarian syndrome women. Methods: Fifty-eight infertile women with polycystic ovary syndrome (PCOS) have been included in this research article. Twenty-nine of them did not undergo ovul

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Zakharov, S.V. "Cytokine profile in patients with early latent syphilis." Medicni perspektivi 23, no. 1 (2018): 71–75. https://doi.org/10.26641/2307-0404.2018.1.124933.

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The purpose of this study was to study the change in the content of the most active cytokines (interleukins 6 and 10) during the formation of the immune response in patients with latent early syphilis, as well as to study the possible relationship between the concentrations of these cytokines and the duration of the disease. In 50 patients with early latent syphilis, the concentration of interleukins 6 and 10 in serum was studied. The serum level of interleukins was studied by the enzyme immunoassay. A statistically significant increase in the concentration of interleukin 6 in the blood of pat

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BRINCKMANN, Roland, Max S. TOPP, Ildikó ZALÁN, et al. "Regulation of 15-lipoxygenase expression in lung epithelial cells by interleukin-4." Biochemical Journal 318, no. 1 (1996): 305–12. http://dx.doi.org/10.1042/bj3180305.

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We have studied the expression of the 15-lipoxygenase gene in various permanent mammalian cell lines in response to interleukins-4 and -13, and found that none of the cell lines tested expressed 5-, 12- or 15-lipoxygenase when cultured under standard conditions. However, when the lung carcinoma cell line A549 was maintained in the presence of either interleukin for 24 h or more, we observed a major induction of 15-lipoxygenase, as indicated by quantification of 15-lipoxygenase mRNA, by immunohistochemistry, by immunoblot analysis and by enzyme activity assays. This effect was 15-lipoxygenase-s

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Diwan, Zahraa Jabbar, and Wasan Addai Al-Marsomy. "Estimation of Some Pro- and Anti-Inflammatory Interleukins in Rheumatoid Arthritis of Iraqi Patients." Medical Journal of Babylon 21, no. 3 (2024): 738–41. http://dx.doi.org/10.4103/mjbl.mjbl_982_23.

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Abstract Background: Rheumatoid arthritis (RA) is an inflammatory condition that mostly affects synovial joints. It produces severe swelling and ongoing inflammation, and as it worsens, the cartilage and bone begin to erode, resulting in deformed joints and bone erosion. Objectives: The purpose of this study is to evaluate the levels of anti-cyclic citrullinated peptide (anti-CCP) antibodies and determine the role of interleukin-1 beta (IL-1β), interleukin-18 (IL-18), interleukin-38 (IL-38), and transforming growth factor-beta2 (TGF-β2) in studied groups (RA patients and apparently healthy con

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Saptarova, Liliyana M., Elvira A. Imelbaeva, Aliya V. Tukhbatova, Shamil N. Galimov, and Natalia A. Mufazalova. "The content of cytokines in the blood of patients with various stages of breast cancer." Kazan medical journal 103, no. 6 (2022): 947–54. http://dx.doi.org/10.17816/kmj70632.

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Background. Cytokine homeostasis is an important factor characterizing the general condition and adaptive capabilities of the body of patients with malignant neoplasms. However, the role of various growth factors and their significance in the development and enhancement of malignant growth in breast cancer remain poorly understood. Aim. To evaluate the levels of cytokines - tumor necrosis factor , interleukins-4, -6, -8 and -10 in the blood serum of patients with different stages of breast cancer in comparison with healthy volunteers. Material and methods. The study was conducted i

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Borodin, P. E. "The relationship between past coronavirus infection and the content of serum interleukins in diseases of the nervous system." Acta Biomedica Scientifica 10, no. 3 (2025): 70–79. https://doi.org/10.29413/abs.2025-10.3.7.

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Background. The mediators of inflammation, which is the most important mechanism for the development of coronavirus infection, accompanied by various complications from the nervous system, both in the acute period of the disease and in the long term, are a group of interleukins. The aim. To clarify the relationship between previous coronavirus infection and the content of serum interleukins in diseases of the nervous system. Methods. The study involved 146 patients with acute cerebrovascular accidents (32), diseases of the central (60) and peripheral nervous system (54), of which 47 had COVID-

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Denefil, O., and О. Bolyukh. "Interleukins changes in blood of non-ethanol liver damage rats of different sex." Journal of Education, Health and Sport 12, no. 8 (2022): 428–37. http://dx.doi.org/10.12775/jehs.2022.12.08.045.

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Non-alcoholic liver disease is associated with liver injury, such as steatosis, steatohepatitis, fibrosis and cirrhosis. During their development, inflammation is occure and organs damage develops by help of cytokines influences. The intensity of injury depends on sex. The aim of the study was to evaluate changes of interleukins in the blood of male and female rats with hepatosis, hepatitis used by overdrinking of glucose. Material and methods of investigation. The experiments were performed on 60 male and 60 female outbred rats aged from four monthes (start of experiment). Animals were divide

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Rahman, Eman, Sri Muchtar, Farida Tabri, et al. "EVALUATION OF INTERLEUKIN-12 AND INTERLEUKIN-4 LEVELS IN MULTIBACILLARY-TYPE LEPROSY PATIENT 12 MONTHS AFTER RIFAMPICIN OFLOXACIN MINOCYCLINE COMBINATION THERAPY." International Journal of Medical Reviews and Case Reports 2, Reports in Surgery and Dermatolo (2018): 1. http://dx.doi.org/10.5455/ijmrcr.multibacillary-type-leprosy-interleukins.

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Eman, Arif Rahman, Vitayani Muchtar Sri, Tabri Farida, et al. "EVALUATION OF INTERLEUKIN-12 AND INTERLEUKIN-4 LEVELS IN MULTIBACILLARY-TYPE LEPROSY PATIENT 12 MONTHS AFTER RIFAMPICIN OFLOXACIN MINOCYCLINE COMBINATION THERAPY." International Journal of Medical Reviews and Case Reports 2, no. 4 (2018): 161–65. https://doi.org/10.5455/IJMRCR.MULTIBACILLARY-TYPE-LEPROSY-INTERLEUKINS.

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Background: Leprosy is a chronic infectious disease caused by Mycobacterium leprae. In leprosy, cell-mediated immune responses are an important aspect of host resistance to mycobacterial infections and allegedly governed by anequilibrium between type 1 cytokines including Interleukin-12 (IL-12); with type 2 cytokines such as Interleukin-4 (IL-4). Currently, the World Health Organization (WHO) recommends 3 leprosy treatment regimens, one of them is Rifampicin Ofloxacin Minocycline (ROM). To date, studies on the effects of ROM on leprosy have been limited, none have specifically assessed the eff

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Digban, Awharentomah Kester, Matthew Eturhobore Adu, and Mary Abiodun Adenuga. "EVALUATION OF SERUM INTERLEUKINS 1 AND 10 IN TYPE 2 DIABETES MELLITUS SUBJECTS IN BENIN CITY." FUDMA JOURNAL OF SCIENCES 7, no. 2 (2023): 146–51. http://dx.doi.org/10.33003/fjs-2023-0702-1203.

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Diabetes mellitus is a metabolic and endocrinological disease that results in hyperglycemia as a result of either insulin absence or non-responsiveness of insulin receptors. Interleukins have been implicated in the pathogenesis of diabetes mellitus. This study sought to evaluate serum interleukin-1 and 10 in diabetes mellitus. A total of three hundred subjects comprising of one hundred and eighty diabetes mellitus and one hundred and twenty apparently healthy subjects were recruited. Of the one hundred and eighty diabetes mellitus is made of 41.67% male and 58.33% females. Venous blood samples

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Pucci, P., R. Siciliano, P. Ferranti, A. Malorni, and G. Marino. "Mass spectrometric characterization of recombinant human interleukins 1 beta." Biotechnology and Applied Biochemistry 12, no. 4 (1990): 357–63. http://dx.doi.org/10.1111/j.1470-8744.1990.tb00107.x.

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The cDNA coding for amino acid residues 121–269 of human interleukin 1 beta was cloned and expressed at Sclavo Research Center by C. Baldari et al. (1987, EMBO J. 6, 229–234) using Saccharomyces cerevisiae as the host cell. The purified protein showed a very low specific activity when compared to that of a mature recombinant interleukin expressed from Escherichia coli. Preliminary experiments indicated the occurrence of post‐translational events in the yeast‐derived protein. In an attempt to correlate the structural modifications and the biological activity of recombinant interleukins, the two

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Agarkov, N. M., K. F. Makkonen, A. A. Titov, D. N. Belchikova, and L. V. Kolpina. "Immune pleiotropic effect of telmisartan in arterial hypertension." Medical Immunology (Russia) 24, no. 4 (2022): 831–36. http://dx.doi.org/10.15789/1563-0625-ipe-2476.

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Arterial hypertension (AH) is among the life-threatening diseases and requires permanent antihypertensive therapy, including telmisartan. However, the effect of telmisartan upon systemic interleukin profile in elderly hypertensive patients requires further study, due to the limited data on previously analyzed interleukins. The aim of our study was to evaluate the immune pleiotropic effect of telmisartan upon miultiple pro- and anti-inflammatory blood interleukins in the patients with hypertension. The study included examination of 74 patients aged 60-74 years suffering from hypertension treate

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Santos, Rebeka Thiara Nascimento dos, Luísa Priscilla Oliveira de Lima, Maria Tereza Cartaxo Muniz, Pâmella Recco Álvares, Márcia Maria Fonseca da Silveira, and Ana Paula Veras Sobral. "Genetic polymorphism of interleukins 6 and 17 correlated with apical periodontitis: A Cross-sectional study." Brazilian Dental Journal 34, no. 5 (2023): 22–28. http://dx.doi.org/10.1590/0103-6440202305486.

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Abstract Interleukins 6 and 17 act in bone resorption in the presence of infections of endodontic origin for host defense. Genetic polymorphisms may be associated with increased bone loss, represented by areas of large periapical lesions. This study aimed to verify the frequency of interleukin 6 and 17 gene polymorphism in patients with asymptomatic apical periodontitis or chronic apical abscess and to verify the existence of correlations between periapical lesion area with age, gender, and presence of the polymorphism, in the studied population, in the state of Pernambuco. A population consis

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Kuryltsiv, Nadiya B., and Kateryna M. Halei. "THE ROLE OF INTERLEUKINS AND THEIR INHIBITORS IN THE DEVELOPMENT OF AUTOIMMUNE UVEITIS." Wiadomości Lekarskie 72, no. 4 (2019): 716–22. http://dx.doi.org/10.36740/wlek201904141.

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Introduction: Autoimmune uveitis (AU) is an inflammation of the uvea due to an autoimmune reaction to self-antigens. There are no standardized treatment protocols for AU. A new class of drugs called biologics, that target the various mediators of the inflammation cascade, may potentially provide more effective and less toxic corticosteroids treatment of AU. The aim: The aim of this review was to make the evaluatation of the interleukins influence on intraocular inflammation in available literature and summarize the expediency of using anti-interleukins agent in case of AU. Material and methods

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Noor, Jamal Mohammed, and A. Al-fahham Ali. "Pathophysiology and Potential Clinical Significance of Il-5: A Review Article." INTERNATIONAL JOURNAL OF HEALTH & MEDICAL RESEARCH 04, no. 01 (2025): 18–21. https://doi.org/10.5281/zenodo.14627363.

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Interleukins belong to the group of cytokines that play a key role in immune system cell signaling. Among them, Interleukin-5 (IL-5) gains paramount significance in the regulation of eosinophils, which are thinly scattered in most allergic as well as inflammatory conditions, especially asthma. A biochemical characterization of IL-5 is a prerequisite for understanding the basic aspects of its function and finding a precise treatment. Interleukin-5 (IL-5) is a critical cytokine that primarily drives the development and differentiation of eosinophils and B cells, playing a key role in the allergi

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Peluzzo, Amanda M., and Michael V. Autieri. "Challenging the Paradigm: Anti-Inflammatory Interleukins and Angiogenesis." Cells 11, no. 3 (2022): 587. http://dx.doi.org/10.3390/cells11030587.

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Angiogenesis is a vital biological process, and neovascularization is essential for the development, wound repair, and perfusion of ischemic tissue. Neovascularization and inflammation are independent biological processes that are linked in response to injury and ischemia. While clear that pro-inflammatory factors drive angiogenesis, the role of anti-inflammatory interleukins in angiogenesis remains less defined. An interleukin with anti-inflammatory yet pro-angiogenic effects would hold great promise as a therapeutic modality to treat many disease states where inflammation needs to be limited

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Asif, Roha, Ammara Khalid, Tolga Mercantepe, et al. "Role of Interleukins in Type 1 and Type 2 Diabetes." Diagnostics 15, no. 15 (2025): 1906. https://doi.org/10.3390/diagnostics15151906.

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Background: Despite distinct etiologies, type 1 diabetes (T1D) and type 2 diabetes (T2D) share chronic inflammation as a core feature. Interleukins, key immune mediators, play important yet still not fully understood roles in the development and complications of both conditions. Objective: This narrative review aims to provide a comprehensive and critical synthesis of current evidence on the role of key interleukins in T1D and T2D, highlighting their immunological functions, genetic associations, clinical correlations, and translational potential. Methods: A targeted literature search was cond

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Lesan, Andrei, Milena Adina Man, Roxana Maria Nemes, et al. "Serum Interleukin 4 and 6 Levels Measured Using the ELISA Method in Patients with Acquired Bronchiectasis Compared to Healthy Subjects. An anti-inflammatory and pro-inflammatory relation." Revista de Chimie 70, no. 7 (2019): 2410–14. http://dx.doi.org/10.37358/rc.19.7.7351.

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Evaluation of the inflammatory response based on the Interleukin 4 and Interleukin 6 levels in patients with acquired bronchiectasis (non-cystic fibrosis) and healthy controls. The study was conducted on a group of 77 subjects, divided into 2 lots: the first lot consisting of 57 patients with acquired bronchiectasis objectified by Computed Tomography and 20 healthy individuals. The serum Interleukins 4 and 6 levels were measured using the ELISA biochemical spectrophotometry test. The results are significant from a statistical point of view, especially when it comes to the mean value of Interle

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Galli Sanchez, Ana Paula, and Tatiane Ester Aidar Fernandes. "The Simultaneous Inhibition of IL‑4 and IL‑13 by Dupilumab." Journal of Clinical Research in Dermatology 8, no. 2 (2021): 1–4. http://dx.doi.org/10.15226/2378-1726/8/2/001138.

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Interleukins (IL) IL-4 and IL-13 are key players in diseases in which the Type 2 immune response is predominant, such as atopic dermatitis (AD), asthma, and chronic rhinosinusitis with nasal polyposis (CRSwNP), that are currently being treated with dupilumab. Dupilumab is a fully human IgG4 monoclonal antibody that targets the IL-4 receptor alpha chain (IL-4Rα), preventing both IL-4 and IL-13 mediated signaling. This mini-review summarizes the IL-4 receptor system as well as the mechanism of action of dupilumab. Keywords: IL-4; IL-13; dupilumab; Type 2 immunity Abbreviations AD: Atopic Dermati

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Onwuasoanya, Uche Francisca, Chinelo Ursula Umedum, Ogochukwu Mary-Theodora Barbara Inwelegbu, Patricia Amaka Egbe, Justina Chimezie Akulue, and Immaculata Ogochukwu Uduchi. "Effects of Helicobacter pylori Infection on Immunoglobulins and Interleukins in Infected Patients: A Cross-sectional Study in Nnewi North, Nigeria." Microbiology Research Journal International 35, no. 4 (2025): 130–37. https://doi.org/10.9734/mrji/2025/v35i41568.

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The debilitating nature of infectious diseases has drastically reduced the health standard of individuals in the society. This study was conducted to evaluate the effects of Helicobacter pylori infection on the immunoglobulins and interleukins of infected patients at Nnewi North, Nigeria. Two hundred (200) blood samples were aseptically collected from different age groups in the sampled communities (Umudim, Uruagu, Otolo, and Nnewichi) at Nnewi North using well-capped sterile plain bottles. The levels of immunoglobulin G (IgG), immunoglobulin M (IgM), interleukin-6 and interleukin-10 were dete

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Malvezzi, Helena, Camila Hernandes, Carla A. Piccinato, and Sérgio Podgaec. "Interleukin in endometriosis-associated infertility-pelvic pain: systematic review and meta-analysis." Reproduction 158, no. 1 (2019): 1–12. http://dx.doi.org/10.1530/rep-18-0618.

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The objective is to study the significance of altered interleukin levels in endometriosis-related infertility or pelvic pain. The present systematic review and meta-analysis includes a discussion on the roles of interleukin in the physiopathology of endometriosis-associated infertility and/or pelvic pain. We included all studies in which interleukins in peritoneal fluid, follicular fluid or serum from patients were measured and that correlated the findings with either peritoneal or deep endometriosis-associated infertility or pelvic pain. For the meta-analysis, we selected studies on the follo

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Zhang, Lili, Jianhua Hu, Chunyan Gou, et al. "Serum Interleukins as Potential Prognostic Biomarkers in HBV-Related Acute-on-Chronic Liver Failure." Mediators of Inflammation 2022 (September 8, 2022): 1–13. http://dx.doi.org/10.1155/2022/7794890.

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Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is relatively common in China and has complex pathogenesis, difficult clinical treatment, and poor prognosis. Immune status is an important factor affecting ACLF prognosis. Interleukins are a family of secreted lymphocyte factors that interact with a host of cell types including immune cells. These signaling molecules play important roles in transmitting information; regulating immune cells; mediating the activation, proliferation, and differentiation of T and B cells; and modulating inflammatory responses. Many studies have i

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Greco, Luana, Valentina Russo, Cinzia Rapino, et al. "Characterization of Endocannabinoid System and Interleukin Profiles in Ovine AEC: Cannabinoid Receptors Type-1 and Type-2 as Key Effectors of Pro-Inflammatory Response." Cells 9, no. 4 (2020): 1008. http://dx.doi.org/10.3390/cells9041008.

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Amniotic epithelial cells (AEC) have been proposed as promising clinical candidates for regenerative medicine therapies due to their immunomodulatory capacity. In this context, the endocannabinoid system (ECS) has been identified as mediating the immune-stem cell dialogue, even if no information on AEC is available to date. Therefore, this study was designed to assess whether ECS is involved in tuning the constitutive and lipopolysaccharide (LPS)-induced ovine AEC anti-inflammatory and pro-inflammatory interleukin (IL-10, IL-4, and IL-12) profiles. Firstly, interleukins and ECS expressions wer

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Edan Alsaimary, Ihsan, and Falih Hmood Mezban. "Molecular Assessment of Gene Expression for Interleukine-4 and Interleukin-17 among Patients with Human Bronchial Asthma by Conventional and Real Time q-PCR Techniques." International Journal of Science and Research (IJSR) 10, no. 2 (2021): 165–69. https://doi.org/10.21275/sr21119160619.

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Kenbaeva, D. K., and Z. A. Manambaeva. "PECULIARITIES OF CYTOKINE REGULATION IN PATIENTS WITH MALIGNANT TUMORS OF THE CERVIX DURING CANCER THERAPY." Russian Journal of Oncology 18, no. 1 (2013): 36–38. http://dx.doi.org/10.17816/onco39971.

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The study included 117 patients with cervical cancer stage IIB and III undergoing combined radiotherapy and also specific immunotherapy and adoptive immunotherapy. The dynamics of a number of cytokines content has been defined (interleukin-2, -6, -10, -12, tumor necrosis factor-alpha). There was a significant excess of anti-inflammatory factors over stimulators of proliferation and differentiation of lymphocytes against the reduction of almost all the interleukins. The degree of impairment was dependent on the stage of the tumor. Application of the treatment method, which includes a specific a

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Lee, G., D. Vollmer, and X. Han. "A Phytocannabinoid Formula Containing Palmitoylethanolamide, Acmella Oleracea Extract, and Bovine Colostrum Filtrate Inhibited Cytokine and Chemokine Production in Human Peripheral Blood Mononuclear Cells Stimulated Ex Vivo." Current Topics in Nutraceutical Research 20, no. 2 (2021): 438–46. http://dx.doi.org/10.37290/ctnr2641-452x.20:438-446.

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A phytocannabinoid formula containing copaiba essential oil, palmitoylethanolamide, Sichuan pepper extract, Acmella oleracea extract, cruciferous vegetable extracts blend, and bovine colostrum filtrate was tested for its ex vivo effect on inhibiting stimulated cytokine release in human peripheral blood mononuclear cells. Effects of the phytocannabinoid formula on the peripheral blood mononuclear cells viability were measured by alamarBlue™ to confirm no obvious cytotoxicity. The phytocannabinoid formula was compared to reference compounds for its ability to inhibit both the phytohemagglutinin-

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Aebisher, David, Dorota Bartusik-Aebisher, Agnieszka Przygórzewska, Piotr Oleś, Paweł Woźnicki, and Aleksandra Kawczyk-Krupka. "Key Interleukins in Inflammatory Bowel Disease—A Review of Recent Studies." International Journal of Molecular Sciences 26, no. 1 (2024): 121. https://doi.org/10.3390/ijms26010121.

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Inflammatory bowel disease (IBD) is an immune disorder of the gastrointestinal tract with a complex aetiopathogenesis, whose development is influenced by many factors. The prevalence of IBD is increasing worldwide, in both industrialized and developing countries, making IBD a global health problem that seriously affects quality of life. In 2019, there were approximately 4.9 million cases of IBD worldwide. Such a large number of patients entails significant healthcare costs. In the treatment of patients with IBD, the current therapeutic target is mucosal healing, as intestinal inflammation ofte

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Anisimova, Natalia Yu, Andrey V. Sosnov, Nadezhda E. Ustyuzhanina, Gianfranco Baronzio та Mikhail V. Kiselevsky. "Cytotoxic Activity of Peripheral Blood Mononuclear Leukocytes, Activated by Interleukin-2/β-Cyclodextrin Nanocomposition against Androgen Receptor-Negative Prostate Cancers". ISRN Oncology 2011 (17 серпня 2011): 1–7. http://dx.doi.org/10.5402/2011/405656.

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Nanocomposition comprised of interleukin-2 in suboptimal noneffective concentration and β-cyclodextrin was studied in vitro. This preparation as well as interleukin-2 in optimal concentration was shown to increase natural killer activity to K-562 cells and cytotoxicity of activated peripheral blood mononuclear cells (PBMCs) against PC-3 and DU 145 cells. At the same time β-cyclodextrin or interleukin-2 in equimolar concentrations did not influence the spontaneous killer activity of PBMC. This combination of cyclodextrin + interleukin-2 led to the decrease of interleukin-2 effective concentrati

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Kovalik, Maria E., Monique A. Dacanay, Steven D. Crowley, and Gentzon Hall. "Swollen Feet: Considering the Paradoxical Roles of Interleukins in Nephrotic Syndrome." Biomedicines 12, no. 4 (2024): 738. http://dx.doi.org/10.3390/biomedicines12040738.

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Interleukins are a family of 40 bioactive peptides that act through cell surface receptors to induce a variety of intracellular responses. While interleukins are most commonly associated with destructive, pro-inflammatory signaling in cells, some also play a role in promoting cellular resilience and survival. This review will highlight recent evidence of the cytoprotective actions of the interleukin 1 receptor (IL-1R)- and common gamma chain receptor (IL-Rγc)-signaling cytokines in nephrotic syndrome (NS). NS results from the injury or loss of glomerular visceral epithelial cells (i.e., podocy

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Uspenskiy, Yu P., I. A. Gorbacheva, A. N. Suvorov, M. M. Galagudza, N. V. Baryshnikova, and S. A. Bogdanova. "IMMUNOLOGICAL CHANGES IN THE INVASION OF HELICOBACTER PYLORI: PROSPECTS FOR CREATING VACCINES." Translational Medicine 5, no. 6 (2019): 31–40. http://dx.doi.org/10.18705/2311-4495-2018-5-6-31-40.

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In this article we wrote about main immunologic disorders in Helicobacter pylori infected patients (changes of local, cell and humoral immunity). We have our own data about changes of interleukins 1β, 4 and 8 level in cagA(+) and cagA(−) Helicobacter pylori strains infected patients: we saw that level of proinflammatory interleukin-1β and unterleukin-8 are higher and level of anti-inflammatory interleukin-4 are lower in patients infected cagA(+) strains of Helicobacter pylori. We demonstrated results of different studies about efficacy of anti-Helicobacter pylori vaccines as immunologic prophy

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Sotirović, J., A. Perić, D. Vojvodić, et al. "Serum cytokine profile of laryngeal squamous cell carcinoma patients." Journal of Laryngology & Otology 131, no. 5 (2017): 455–61. http://dx.doi.org/10.1017/s0022215117000573.

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AbstractObjectives:This study aimed to evaluate serum cytokine concentrations in healthy individuals and laryngeal squamous cell carcinoma patients.Methods:A total of 59 laryngeal squamous cell carcinoma patients and 44 healthy controls were included. Multiplex analysis of interleukins 2, 4, 5, 6, 10, 12, 13 and 17 and interferon-gamma with respect to the presence of laryngeal carcinoma, tumour–node–metastasis T stage, nodal involvement and larynx subsite was performed.Results:Statistical analysis revealed no difference in serum cytokine levels between patients and healthy controls. The serum

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Terekhova, O. "Participation of Interleukins in Diabetes Mellitus and Diabetic Nephropathy in Children and Adolescents in Kyrgyzstan." Bulletin of Science and Practice 5, no. 4 (2019): 163–67. http://dx.doi.org/10.33619/2414-2948/41/19.

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The data presented in interleukins plasma concentrations of diabetic nephropathy in children. It studied 130 children and adolescents with type 1 diabetes without diabetic nephropathy with type 1 diabetes mellitus complicated by diabetic nephropathy. It is shown that nephropathy complicated by diabetes is accompanied by activation of cytokine (interleukin) in the blood system reflecting the severity of kidney damage and the whole organism.

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Magyari, Lili. "Interleukins and interleukin receptors in rheumatoid arthritis: Research, diagnostics and clinical implications." World Journal of Orthopedics 5, no. 4 (2014): 516. http://dx.doi.org/10.5312/wjo.v5.i4.516.

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Bredun, Oleksandr, Marina Tymchenko, Inna Faraon, and Oleg Melnikov. "CYTOKINE AND IMMUNOGLOBULIN SPECTRA OF TISSUE EXTRACTS FROM TONSILS OF CHILDREN WITH HYPERTROPHY AND CHRONIC TONSILLITIS." Wiadomości Lekarskie 73, no. 1 (2020): 156–60. http://dx.doi.org/10.36740/wlek202001130.

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The aim: To compare the content of α and γ–interferons, interleukins 1β ,4, 10, IgA, IgG, as well as the level of the general forms of immune complexes in tissue extracts from tonsils of children with hypertrophy and chronic tonsillitis. Materials and methods: We studied tonsils of 25 children aged 5-12 years with hypertrophy of palatine tonsils (HPT) and with chronic tonsillitis (CT). The content of α and γ – interferons, interleukins 1β, 4, 10, IgA, IgG in tonsil extract was determined by immunofluorescence assay. Immune complexes were determined using sedimentary test (3.75% solution of pol

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Xia, Xiang, Zizhen Zhang, Jia Xu, Gang Zhao, and Fengrong Yu. "Comparison of postoperative lymphocytes and interleukins between laparoscopy-assisted and open radical gastrectomy for early gastric cancer." Journal of International Medical Research 47, no. 1 (2018): 303–10. http://dx.doi.org/10.1177/0300060518800909.

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Objective This study aimed to study the effects of laparoscopic-assisted radical gastrectomy (LAG) and open radical gastrectomy (OG) on immune function and inflammatory factors in patients with early gastric cancer. Methods Seventy-five patients with pT1N0M0 gastric cancer in Ren Ji Hospital from August 2017 to January 2018 were studied. Lymphocytes subsets and interleukins were compared preoperatively and on the third postoperative day (POD3) and seventh postoperative day (POD7). Results There were no significant differences in age, sex, body mass index, duration of the operation, estimated b

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Yoon, S. H., M. E. Kim, H. Y. Kim, J. S. Lee, and C. H. Jang. "Inflammatory cytokines and mononuclear cells in sudden sensorineural hearing loss." Journal of Laryngology & Otology 133, no. 2 (2019): 95–101. http://dx.doi.org/10.1017/s0022215119000100.

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AbstractObjectiveThis study evaluated tumour necrosis factor-α, interleukins 10 and 12, and interferon-γ levels, peripheral blood mononuclear cells, and clusters of differentiation 17c and 86 expression in unilateral sudden sensorineural hearing loss.MethodsTwenty-four patients with unilateral sudden sensorineural hearing loss, and 24 individuals with normal hearing and no history of sudden sensorineural hearing loss (who were attending the clinic for other problems), were enrolled. Peripheral blood mononuclear cells, and clusters of differentiation 11c and 86 were isolated and analysed. Plasm

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Szymańska, Beata, Karolina Jurkowska, Brygida Knysz, and Agnieszka Piwowar. "Differences in Expression of Selected Interleukins in HIV-Infected Subjects Undergoing Antiretroviral Therapy." Viruses 14, no. 5 (2022): 997. http://dx.doi.org/10.3390/v14050997.

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The use of combined antiretroviral therapy (cART) inhibits the replication of the Human Immunodeficiency Virus (HIV) and thus may affect the functioning of the immune system, e.g., induce changes in the expression of certain cytokines. The aim was to examine the effect of cART on the expression of selected cytokines: interleukin -4, -7 and -15 in HIV-infected subjects. The test material was the plasma of HIV-infected men and healthy men (C, control group). The levels of interleukin were measured by immunoenzymatic method before cART and one year after treatment in relation to the C group. HIV-

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Moldawer, L. L., G. Svaninger, J. Gelin, and K. G. Lundholm. "Interleukin 1 and tumor necrosis factor do not regulate protein balance in skeletal muscle." American Journal of Physiology-Cell Physiology 253, no. 6 (1987): C766—C773. http://dx.doi.org/10.1152/ajpcell.1987.253.6.c766.

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Recent studies have claimed that interleukin 1-containing preparations increase skeletal protein degradation similar to that seen during infection and inflammation. However, preparations employed have contained other products of activated macrophages, including tumor necrosis factor-alpha. In the present report, we investigated the capability of recombinant-derived murine and human interleukins 1-alpha and 1-beta and human tumor necrosis factor-alpha to affect skeletal protein synthesis and degradation both in vitro and in vivo. Partially purified products of Staphylococcus albus-stimulated hu

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Malevannaya, V., E. Alymbaev, and O. Atykanov. "Evaluation of Treatment of Biliary Tract Dysfunction in Children by the Activity of the Cytokine System." Bulletin of Science and Practice 6, no. 7 (2020): 133–38. http://dx.doi.org/10.33619/2414-2948/56/15.

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The study presents data on the examination of 100 children aged 7 to 14 years with a disturbance of the motor-evacuation function of the bile excreting system in the hypomotor type (57 children — I clinical group) and hypermotor type (43 children — II clinical group). As a control group, 20 somatically healthy children were examined. It was shown that with hypomotor dyskinesia of the gallbladder, the activity of the cytokine (interleukin) system in the blood plasma was significantly superior to activity in hypermotor dyskinesia. Combined therapy in children’s second clinical group leads to nor

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Nassar, Auhood, Abdel Rahman N. Zekri, Mostafa H. Elberry, et al. "Somatic Mutations Alter Interleukin Signaling Pathways in Grade II Invasive Breast Cancer Patients: An Egyptian Experience." Current Issues in Molecular Biology 44, no. 12 (2022): 5890–901. http://dx.doi.org/10.3390/cimb44120401.

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This study aimed to investigate the impact of somatic mutations on various interleukin signaling pathways associated with grade II invasive breast cancer (BC) in Egyptian patients to broaden our understanding of their role in promoting carcinogenesis. Fifty-five grade II invasive BC patients were included in this study. Data for somatic mutations in 45 BC patients were already available from a previous study. Data for somatic mutations of 10 new BC patients were included in the current study. Somatic mutations were identified using targeted next-generation sequencing (NGS) to study their invol

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Bednarz-Misa, Iwona, Dorota Diakowska, Izabela Szczuka, et al. "Interleukins 4 and 13 and Their Receptors Are Differently Expressed in Gastrointestinal Tract Cancers, Depending on the Anatomical Site and Disease Advancement, and Improve Colon Cancer Cell Viability and Motility." Cancers 12, no. 6 (2020): 1463. http://dx.doi.org/10.3390/cancers12061463.

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Immunosuppressive interleukins (IL)-4 and 13 may directly promote cancer but neither their status nor role in gastrointestinal tract is clarified. We aim at quantifying ILs and their receptors in paired normal-tumor samples (n = 49/51) and sera (n = 263), using immunoassays and RTqPCR, and screening for their effect on colonic cancer cells. Both ILs were elevated locally at protein level in all cancers but only IL13 transcripts in colon were upregulated. Interleukin and their receptor expression reflected cancer pathology to varying degrees, with the association frequently inverse and manifest

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