Academic literature on the topic 'Intermittent chronic hypoxia'

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Journal articles on the topic "Intermittent chronic hypoxia"

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Martinez, Chloe-Anne, Bernadette Kerr, Charley Jin, Peter Cistulli, and Kristina Cook. "Obstructive Sleep Apnea Activates HIF-1 in a Hypoxia Dose-Dependent Manner in HCT116 Colorectal Carcinoma Cells." International Journal of Molecular Sciences 20, no. 2 (2019): 445. http://dx.doi.org/10.3390/ijms20020445.

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Obstructive sleep apnea (OSA) affects a significant proportion of the population and is linked to increased rates of cancer development and a worse cancer outcome. OSA is characterized by nocturnal intermittent hypoxia and animal models of OSA-like intermittent hypoxia show increased tumor growth and metastasis. Advanced tumors typically have regions of chronic hypoxia, activating the transcription factor, HIF-1, which controls the expression of genes involved in cancer progression. Rapid intermittent hypoxia from OSA has been proposed to increase HIF-1 activity and this may occur in tumors. T
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Prabhakar, Nanduri R. "Invited Review: Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms." Journal of Applied Physiology 90, no. 5 (2001): 1986–94. http://dx.doi.org/10.1152/jappl.2001.90.5.1986.

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To the majority of the population, recurrent episodes of hypoxia are more likely encountered in life than sustained hypoxia. Until recently, much of the information on the long-term effects of intermittent hypoxia has come from studies on human subjects experiencing chronic recurrent apneas. Recent development of animal models of intermittent hypoxia and techniques for exposing cell cultures to alternating cycles of hypoxia have led to new information on the effects of episodic hypoxia on oxygen-sensing mechanisms in the carotid body chemoreceptors and regulation of gene expression. The purpos
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Mouradian, Gary C., Satyan Lakshminrusimha, and Girija G. Konduri. "Perinatal Hypoxemia and Oxygen Sensing." Comprehensive Physiology 11, no. 2 (2021): 1653–77. https://doi.org/10.1002/j.2040-4603.2021.tb00155.x.

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AbstractThe development of the control of breathing begins in utero and continues postnatally. Fetal breathing movements are needed for establishing connectivity between the lungs and central mechanisms controlling breathing. Maturation of the control of breathing, including the increase of hypoxia chemosensitivity, continues postnatally. Insufficient oxygenation, or hypoxia, is a major stressor that can manifest for different reasons in the fetus and neonate. Though the fetus and neonate have different hypoxia sensing mechanisms and respond differently to acute hypoxia, both responses prevent
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Ma, Qiang, Renxiao Zhang, Yuliang Wei, Mengqing Liang, and Houguo Xu. "Effects of Intermittent and Chronic Hypoxia on Fish Size and Nutrient Metabolism in Tiger Puffer (Takifugu rubripes)." Animals 14, no. 17 (2024): 2470. http://dx.doi.org/10.3390/ani14172470.

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Intermittent and chronic hypoxia are common stresses to marine fish, but the different responses of fish to intermittent and chronic hypoxia have not been well-known. In this study, tiger puffers were farmed in normoxia conditions (NO, 6.5 ± 0.5 mg/L), intermittent hypoxia (IH, 6.5 ± 0.5 mg/L in the day and 3.5 ± 0.5 mg/L in the night), or choric hypoxia (CH, 3.5 ± 0.5 mg/L) conditions for 4 weeks, after which the growth, nutrient metabolism and three hifα isoforms expression were measured. Both intermittent and chronic hypoxia decreased the fish growth and visceral weight but increased the fe
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Hunyor, Imre, and Kristina M. Cook. "Models of intermittent hypoxia and obstructive sleep apnea: molecular pathways and their contribution to cancer." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 315, no. 4 (2018): R669—R687. http://dx.doi.org/10.1152/ajpregu.00036.2018.

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Obstructive sleep apnea (OSA) is common and linked to a variety of poor health outcomes. A key modulator of this disease is nocturnal intermittent hypoxia. There is striking epidemiological evidence that patients with OSA have higher rates of cancer and cancer mortality. Small-animal models demonstrate an important role for systemic intermittent hypoxia in tumor growth and metastasis, yet the underlying mechanisms are poorly understood. Emerging data indicate that intermittent hypoxia activates the hypoxic response and inflammatory pathways in a manner distinct from chronic hypoxia. However, t
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Usategui-Martín, Ricardo, Álvaro Del Del Real, José A. Sainz-Aja, et al. "Analysis of Bone Histomorphometry in Rat and Guinea Pig Animal Models Subject to Hypoxia." International Journal of Molecular Sciences 23, no. 21 (2022): 12742. http://dx.doi.org/10.3390/ijms232112742.

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Hypoxia may be associated with alterations in bone remodeling, but the published results are contradictory. The aim of this study was to characterize the bone morphometry changes subject to hypoxia for a better understanding of the bone response to hypoxia and its possible clinical consequences on the bone metabolism. This study analyzed the bone morphometry parameters by micro-computed tomography (μCT) in rat and guinea pig normobaric hypoxia models. Adult male and female Wistar rats were exposed to chronic hypoxia for 7 and 15 days. Additionally, adult male guinea pigs were exposed to chroni
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Carreres, Lydie, Marion Mercey-Ressejac, Keerthi Kurma, et al. "Chronic Intermittent Hypoxia Increases Cell Proliferation in Hepatocellular Carcinoma." Cells 11, no. 13 (2022): 2051. http://dx.doi.org/10.3390/cells11132051.

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Obstructive sleep apnea (OSA) syndrome is characterized by chronic intermittent hypoxia and is associated with an increased risk of all-cause mortality, including cancer mortality. Hepatocellular carcinoma (HCC) is the most common type of liver cancer, characterized by increasing incidence and high mortality. However, the link between HCC and OSA-related chronic intermittent hypoxia remains unclear. Herein, we used a diethylnitrosamine (DEN)-induced HCC model to investigate whether OSA-related chronic intermittent hypoxia has an impact on HCC progression. To elucidate the associated mechanisms
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Wu, Ming-Jane, Stéphane Vinit, Chun-Lin Chen, and Kun-Ze Lee. "5-HT7 Receptor Inhibition Transiently Improves Respiratory Function Following Daily Acute Intermittent Hypercapnic-Hypoxia in Rats With Chronic Midcervical Spinal Cord Contusion." Neurorehabilitation and Neural Repair 34, no. 4 (2020): 333–43. http://dx.doi.org/10.1177/1545968320905806.

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Background. Intermittent hypoxia can induce respiratory neuroplasticity to enhance respiratory motor outputs following hypoxic treatment. This type of respiratory neuroplasticity is primarily mediated by the activation of Gq-protein-coupled 5-HT2 receptors and constrained by Gs-protein-coupled 5-HT7 receptors. Objective. The present study hypothesized that the blockade of 5-HT7 receptors can potentiate the effect of intermittent hypercapnic-hypoxia on respiratory function after cervical spinal cord contusion injury. Methods. The ventilatory behaviors of unanesthetized rats with midcervical spi
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Savransky, Vladimir, Ashika Nanayakkara, Jianguo Li, et al. "Chronic Intermittent Hypoxia Induces Atherosclerosis." American Journal of Respiratory and Critical Care Medicine 175, no. 12 (2007): 1290–97. http://dx.doi.org/10.1164/rccm.200612-1771oc.

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Makarenko, Vladislav V., Ying-Jie Peng, Shakil A. Khan, Jayasri Nanduri, Aaron P. Fox, and Nanduri R. Prabhakar. "Long-term facilitation of catecholamine secretion from adrenal chromaffin cells of neonatal rats by chronic intermittent hypoxia." Journal of Neurophysiology 122, no. 5 (2019): 1874–83. http://dx.doi.org/10.1152/jn.00435.2019.

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In neonates, catecholamine (CA) secretion from adrenal medullary chromaffin cells (AMC) is an important mechanism for maintaining homeostasis during hypoxia. Nearly 90% of premature infants experience chronic intermittent hypoxia (IH) because of high incidence of apnea of prematurity, which is characterized by periodic stoppage of breathing. The present study examined the effects of repetitive hypoxia, designed to mimic apnea of prematurity, on CA release from AMC of neonatal rats. Neonatal rats were exposed to either control conditions or chronic intermittent hypoxia (IH) from ages postnatal
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Dissertations / Theses on the topic "Intermittent chronic hypoxia"

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Yang, Tianxiang. "Influence of chronic intermittent hypoxia (CIH) in retinal neovascularization and vascular remodeling." Electronic Thesis or Diss., Sorbonne université, 2024. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2024SORUS059.pdf.

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Les rétinopathies néovasculaires et les œdèmes sont des complications menaçant la vue des rétinopathies ischémiques, telles que la rétinopathie du prématuré (ROP) et la rétinopathie diabétique (DR). L'apnée du sommeil qui conduit à une hypoxie chronique intermittente (CIH) est un facteur de risque indépendant de maladie grave, mais les mécanismes sous-jacents sont inconnus. Nous montrons ici que le CIH expérimental pendant la phase ischémique de la rétinopathie induite par l'oxygène chez la souris réduit considérablement la revascularisation bénéfique de la rétine ischémique et augmente la per
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Tam, Tin-lap Leonard, and 譚天立. "The influence of acute, chronic or chronic intermittent hypoxia on NO release from the renal circulation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B30401756.

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Tadtayev, Sergiy. "Stereological investigation of specific brain regions in a developmental model of chronic intermittent hypoxia." Thesis, Brunel University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439804.

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Ramakrishnan, Devi Prasadh. "STUDIES ON NEUROPEPTIDE-Y EFFLUX FROM ADULT RAT ADRENAL MEDULLA – EFFECT OF CHRONIC INTERMITTENT HYPOXIA." Cleveland, Ohio : Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1201202472.

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Lam, Siu-yin Sylvia. "Expression and function of hypoxia-inducible factor, cytokines and renin-angiotensin system in the carotid body during chronic and intermittent hypoxia." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41897171.

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Hung, Ming-wai. "Protective effects of melatonin on hippocampal and vascular injuries induced by chronic and intermittent hypoxia in rats." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B39793941.

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Hung, Ming-wai, and 洪明偉. "Protective effects of melatonin on hippocampal and vascular injuries induced by chronic and intermittent hypoxia in rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B39793941.

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Liu, Yu, and 刘宇. "Nitric oxide production, oxidative stress, and inflammation in the rat adrenal medulla during chronic and intermittent hypoxia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/198929.

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Adrenal gland, as an important effector tissue of the sympathetic nervous system, has critical roles in cardiovascular system under both chronic hypoxia (CH) and intermittent hypoxia (IH) conditions. Nitric oxide (NO), synthesized by nitric oxide synthases (NOS), is the most important intracellular signaling molecule, as well as free radical in response to hypoxia. Yet the regulation and effects of endogenous NO production mediated in the adrenal medulla induced by hypoxia remains largely unknown. We first studied how endogenous NO production were regulated by different NOS in rat adrenal med
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Ekwudo, Millicent N., and EAST TENNESSEE STATE UNIVERSITY. "The Effect of Chronic Mild Intermittent Hypoxia, and 2, 4-Dinitrophenol on Longevity and Gene Expression in Daphnia magna." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/asrf/2021/presentations/35.

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The mitochondria are organelles where energy in the form of ATP (Adenosine Triphosphate) is produced. During low oxygen supply (hypoxia) and mitochondrial uncoupling, ATP synthesis is reduced and AMP (Adenosine Monophosphate) accumulates in the cells. This increase in AMP: ATP ratio stimulates the AMP-Activated Kinase (AMPK) pathway, known to improve healthspan and lifespan by increasing mitochondrial biogenesis (making new mitochondria), decreasing oxidative stress and inflammation, and proteotoxicity (by degrading non-functional organelles and proteins). Here, the life/healthspan extending p
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Yeung, Hang-mee. "Oxidative stress, impaired calcium homeostasis and nitric oxide production in the heart of rats in chronic and intermittent hypoxia." Click to view the E-thesis via HKUTO View the Table of Contents & Abstract, 2009. http://sunzi.lib.hku.hk/hkuto/record/B4403345X.

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Book chapters on the topic "Intermittent chronic hypoxia"

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Iacobas, Sanda, and Dumitru Andrei Iacobas. "Effects of Chronic Intermittent Hypoxia on Cardiac Rhythm Transcriptomic Networks." In Intermittent Hypoxia and Human Diseases. Springer London, 2012. http://dx.doi.org/10.1007/978-1-4471-2906-6_2.

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Yang, Huang-Tian, Yi Zhang, Zhi-Hua Wang, and Zhao-Nian Zhou. "Protective Effects of Chronic Intermittent Hypoxia Against Myocardial Ischemia/Reperfusion Injury." In Intermittent Hypoxia and Human Diseases. Springer London, 2012. http://dx.doi.org/10.1007/978-1-4471-2906-6_4.

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Burtscher, Martin. "Effects of Intermittent Hypoxic Training on Exercise Tolerance in Patients with Chronic Obstructive Pulmonary Disease." In Intermittent Hypoxia and Human Diseases. Springer London, 2012. http://dx.doi.org/10.1007/978-1-4471-2906-6_10.

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Levashov, Mikhail I. "Beneficial Effects of Intermittent Normobaric Hypoxic Training on Respiratory Function in Patients with Chronic Pulmonary Diseases." In Intermittent Hypoxia and Human Diseases. Springer London, 2012. http://dx.doi.org/10.1007/978-1-4471-2906-6_9.

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Iturriaga, R., S. Rey, R. Del Rio, E. A. Moya, and J. Alcayaga. "Cardioventilatory Acclimatization Induced by Chronic Intermittent Hypoxia." In Advances in Experimental Medicine and Biology. Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-2259-2_37.

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Li, Qing Yun, Chen Juan Gu, Ying Ni Lin, and Qiong Wang. "Chronic Intermittent Hypoxia in Patients with OSA." In Translational Medicine Research. Springer Netherlands, 2022. http://dx.doi.org/10.1007/978-94-024-2168-2_10.

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Row, Barry W. "Intermittent Hypoxia and Cognitive Function: Implications from Chronic Animal Models." In Hypoxia and the Circulation. Springer US, 2007. http://dx.doi.org/10.1007/978-0-387-75434-5_5.

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Edge, Deirdre, Aidan Bradford, and Ken D. O’Halloran. "Chronic Intermittent Hypoxia Increases Apnoea Index in Sleeping Rats." In Advances in Experimental Medicine and Biology. Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-4584-1_48.

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Edge, Deirdre, J. Richard Skelly, Aidan Bradford, and Ken D. O’Halloran. "Respiratory Plasticity in the Behaving Rat Following Chronic Intermittent Hypoxia." In Advances in Experimental Medicine and Biology. Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-5692-7_54.

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Yan, Qiaozhen, and Liping Dong. "Chronic Intermittent Hypoxia Training on Rat Myocardial Mitochondria Atpase Impact Study." In Advances in Intelligent Systems and Computing. Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-2568-1_183.

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Conference papers on the topic "Intermittent chronic hypoxia"

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Liu, Ching-Lung, Chien-Fu F. Chen, Kuo-Hsing Ma, and Yen-Ta Lu. "The effects of chronic intermittent hypoxia on dopaminergic neurodegeneration." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa2011.

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Song, Dongmei, Guoqiang Fang, Sun-Zhong Mao, Gang Liu, Xiaobing Ye, and Shu F. Liu. "A Mouse Model Of Chronic Intermittent Hypoxia Induced Atherosclerosis." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5348.

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Reinke, Christian, Shannon Bevans-Fonti, Dmitry N. Grigoryev, et al. "Chronic Intermittent Hypoxia Increases Alveolar Surface Area In Mice." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a6634.

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Zhang, Xilong, Hanpeng Huang, and Xiaofeng Zhang. "Adiponectin can improve chronic intermittent hypoxia induced genioglossus contractile dysfunction." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa2289.

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Voituron, Nicolas, David C. Andrade, Camilo Toledo, Jean-Paul Richalet, and Rodrigo Del Rio. "Carbamylated erythropoietin prevents cardio-respiratory dysfunctions induced by chronic intermittent hypoxia." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.pa417.

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Caballero Eraso, Candelaria, Olaia Colinas, Veronica Sobrino, et al. "Changes in CB cell maturation during exposure to chronic intermittent hypoxia." In ERS International Congress 2021 abstracts. European Respiratory Society, 2021. http://dx.doi.org/10.1183/13993003.congress-2021.oa3014.

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Lee, EJ, HC Strollo, B. Zou, et al. "Intermittent Hypoxia (IH), but Not Chronic Hypoxia (CH), Causes Sustained Glucose Intolerance in C57BL/6J Mice." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1067.

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Rao, Harshit, Oanh Le-Hoang, Judith A. Neubauer, and Jagadeeshan Sunderram. "AUGMENTED SYMPATHETIC RESPONSES TO HYPOXIA FOLLOWING CHRONIC INTERMITTENT HYPOXIA ARE HEME OXYGENASE-1 (HO-1) DEPENDENT." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a6633.

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Zou, Ying, and Wei Wang. "Chronic intermittent hypoxia induces the long-term facilitation of genioglossus corticomotor activity." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa2969.

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Drager, Luciano F., Qiaoling Yao, Karen L. Hernandez, et al. "Chronic Intermittent Hypoxia (CIH) Induces Atherosclerosis Via Angiopoietin-Like Proten 4 (Angptl4)." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1050.

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