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Dissertations / Theses on the topic 'Internal picture of the disease'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Martin, Steven Carl. "Homocysteine and vascular disease." Thesis, University of Glasgow, 2003. http://theses.gla.ac.uk/30939/.

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Cardiovascular disease is multifactorial. The main risk factors for developing cardiovascular disease (age, sex, smoking, diabetes, hyperlipidaemia and hypertension) do not explain its development in everyone. New risk factors are continually being sought in order to better understand and treat the disease process. In recent years homocysteine has been proposed as a risk factor for the development of premature cardiovascular disease as a consequence of the accelerated arterial and venous thrombotic disease seen in homocystinuria as a result of a single gene defect. This theory has been difficu

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2

Edwards, Nicola Catherine. "The effect of spironolactone on cardiovascular disease in early stage chronic kidney disease." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/2938/.

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This thesis examined whether patients with early stage chronic kidney disease (CKD) have abnormalities of arterial stiffness and cardiac function. Aldosterone is known to promote inflammation and fibrosis in the arteries, heart and kidney. Treatment with spironolactone, which blocks aldosterone at the mineralocorticoid receptor might be effective at reducing such injury. To address these hypotheses, I performed an observational study in patients with early stage CKD without known cardiovascular disease and healthy volunteers. Aortic stiffness and myocardial structure and function were assessed

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3

Jhund, Pardeep S. "Socioeconomic deprivation and cardiovascular disease." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/2213/.

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Socioeconomic deprivation (SED) is inversely associated with mortality. The most deprived are at a higher risk of all cause mortality and cardiovascular mortality. However, only limited study of the relationship between SED and non-fatal cardiovascular disease has been previously undertaken. In those studies that have examined the relationship between SED and non-fatal cardiovascular disease, analyses have been limited to one form of cardiovascular disease (CVD), such as myocardial infarction or stroke and often prevalent disease. Furthermore, these studies have often failed to examine the ass

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4

Dodd, Will. "Pediatric Respiratory Disease." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/8938.

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5

Neisius, Ulf. "Proteomic, circulating and functional biomarkers of cardiovascular disease." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4740/.

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Cardiovascular disease is the leading cause of morbidity and mortality in the Western world, mainly through cerebrovascular and coronary artery related events. Cardiovascular disease is a chronic progressive disease with different stages. These stages can be assessed by a variety of biomarkers. Biomarker quantification can be used for different purposes: screening, prediction of disease recurrence, therapeutic monitoring, diagnosis and prognostication. Noninvasive, inexpensive diagnostic tests currently applied in clinical practice have a relative high rate of false positive and false negative

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6

Johnson, Carolyn Talbert. "Improving the Dressing Skills of Persons with Alzheimer's Disease Using Picture Cues." The Ohio State University, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=osu1392117988.

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7

Talbert-Johnson, Carolyn. "Improving the dressing skills of persons with Alzheimer's disease using picture cues /." The Ohio State University, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487757723997508.

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8

Ormerod, Julian Oliver Macbeth. "Towards nitrite as a therapy in cardiovascular disease." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/3234/.

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The nitrite anion has traditionally been considered an inert by-product of nitric oxide (NO) metabolism, but is now thought to be an important source of bioactive NO. Work from our department and others have implicated intrinsic vascular wall heme-proteins in a hypoxia-potentiated release of NO. The experiments presented in this thesis were designed to test the hypothesis that vascular wall myoglobin is one of the responsible proteins, and furthermore that the release of NO in relative hypoxia may be useful therapeutically in conditions such as heart failure and myocardial ischaemia. Experimen

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9

Parker, Richard. "Chemokine receptors as therapeutic targets in liver disease." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/6372/.

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There is an urgent need for new insights into the pathology of liver disease to underpin new therapeutic approaches. Chemokines and their receptors are central to the development of liver inflammation. I investigated liver disease using ex-vivo human tissue to analyse gene and protein expression in liver and the nature of inflammation. Animal models of liver disease were used to investigate the effects of manipulating the chemokine system. In Non-Alcoholic Fatty Liver Disease (NAFLD) expression of CCL2 is increased. A subset of monocytes expressed CD11c and CD206, and maintained CCR2 expressio

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10

Rout, Subrat N. "The role of Newcastle disease virus internal proteins in pathogenesis." College Park, Md. : University of Maryland, 2007. http://hdl.handle.net/1903/7422.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2007.<br>Thesis research directed by: Veterinary Medical Science. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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11

Sung, E. Z. H. "Ghrelin, motilin in health and disease." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/51542/.

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Ghrelin is a 28 amino-acid peptide produced predominantly by the stomach. Two main isoforms of ghrelin are currently known (octanoyl- and desoctanoyl ghrelin). It functions as a circulating orexigenic hormone In addition, it has an effect on the nervous, cardiovascular and immune system. Current data suggest that ghrelin may have beneficial anti-inflammatory effects. Chapter 3 in this thesis primarily examines the relationship between ghrelin and inflammation in Crohn’s disease (CD). Modulation of inflammation with infliximab, a powerful anti-TNFα antibody therapy, can increase total ghrelin c

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12

Whiteley, Ellanor Louise. "Characterisation of PDE10A degradation and disease-associated mutations." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/38923/.

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13

Gordon, Tessa. "The peripheral nervous system : injury and disease." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6822/.

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Poor functional outcomes are frequent after peripheral nerve injuries despite the regenerative support of Schwann cells. Whilst motoneurons and to a lesser extent, sensory neurons survive the injuries, outgrowth of axons across the injury site is slow and the neuronal regenerative capacity is progressively reduced when neurons remain without targets and chronically denervated Schwann cells fail to support axon growth. Strategies including brief low frequency electrical stimulation that accelerates axon outgrowth and, in turn, target reinnervation and functional recovery, have excellent potenti

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14

Eddowes, Peter John. "The role of MRI in stratifying and evaluating chronic liver disease." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8126/.

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Chronic liver disease is a highly prevalent condition associated with significant morbidity and mortality. There is need for clinicians to stratify chronic liver disease and for researchers to define meaningful study endpoints. Currently this is often reliant on liver biopsy histology, which is known to be a flawed gold standard. There is a need to develop novel, non-invasive techniques for the evaluation of chronic liver disease that are accurate and reliable. In this thesis I have demonstrated that multiparametric MRI can stage hepatic fibrosis in an unselected cohort with performance compar

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15

Leslie, Wilma S. "Weight management and chronic disease." Thesis, University of Glasgow, 2009. http://theses.gla.ac.uk/1300/.

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Abstract Background: Obesity, in addition to being a serious condition in its own right, is causally associated with many chronic non-communicable diseases, and its prevention, identification and treatment is a public health priority. Results: The main findings of the present thesis were that 1) many drugs, used in the management of chronic disease, have an adverse effect on body weight with weight change of +10kg observed as a real side effect of some. 2) Identification and management of obesity is not a formal part of current practice in many secondary care clinics. While acknowledging the a

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16

Gillis, Keith Andrew. "Oxidative stress and its haemodynamic consequences in chronic kidney disease." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7608/.

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Chronic kidney disease (CKD) is associated with increased cardiovascular risk in comparison with the general population. This can be observed even in the early stages of CKD, and rises in proportion to the degree of renal impairment. Not only is cardiovascular disease (CVD) more prevalent in CKD, but its nature differs too, with an excess of morbidity and mortality associated with congestive cardiac failure, arrhythmia and sudden death, as well as the accelerated atherosclerosis which is also observed. Conventional cardiovascular risk factors such as hypertension, dyslipidaemia, obesity, glyca

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17

Methven, Shona. "Predictors of renal and patient outcomes in chronic kidney disease." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3655/.

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Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease and end stage renal failure. Accurate identification of those with a reduced glomerular filtration rate and significant proteinuria facilitates early diagnosis and risk stratification. This thesis explores the optimal measure of proteinuria, to accurately quantify proteinuria and as a predictor of renal and patient outcomes. We examine the prevalence of CKD in a general population cohort and assess the impact of different estimated glomerular filtration rate (eGFR) formulae. We explore the prognostic ro

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18

Granados, Javier Tadeo. "Molecular genetics of congenital heart disease and Holt-Oram Syndrome." Thesis, University of Nottingham, 2006. http://eprints.nottingham.ac.uk/29865/.

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Heart development is a complex process which is regulated by molecular mechanisms still largely unknown. Disruptions in these processes cause congenital heart defect, that affects over 1 out of every 100 live births and is responsible for most antenatal losses. In the last few decades, several mutations have been shown to cause isolated as well as syndromic congenital heart defects and the genetic contribution to this pathology now is being recognized as important not only for the rare familial cases but also in regard to the much more complex multifactorial varieties of the disease. The work

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19

Jain, Poorva. "Can routinely collected primary care data determine the prevalence of chronic kidney disease and predict clinical events in patients with stages 3 of the disease?" Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/5552/.

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Introduction Chronic Kidney Disease (CKD) is common and associated with cardiovascular morbidity and mortality. Few studies have assessed the real prevalence of CKD and the predictors of morbidity and mortality in this cohort. Methods Using THIN data, the prevalence of CKD 1-5 was ascertained .This was compared to the prevalence on the practice register using QOF Read codes in 2009. Cox proportional hazard models using routinely collected primary care were used identify predictors of i) all-cause mortality and ii) the composite of cardiovascular disease and all-cause mortality. Results The pre

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20

Dodd, Will. "Common Cardiac Disease in the Hospitalized Patient." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/8941.

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21

Satherley, Rose-Marie. "Disordered eating attitudes and behaviours in coeliac disease." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7518/.

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This thesis examines the relationship between coeliac disease (CD) and disordered eating attitudes and behaviours. The literature review describes the development of a theoretical model of disordered eating in CD that will be evaluated throughout this thesis. Chapter Three reports the results of a study that found a high prevalence of disordered eating in CD. Chapter Four reports the results of a qualitative study; participants in this study discussed an increased concern around food that affected their eating patterns. Chapter Five describes the development and validation of the CD Food Attit

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22

Patel, Chirag. "Molecular genetic analysis of familial congenital heart disease." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4471/.

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Development of the human heart is a complex process controlled by multiple genes (in interacting pathways), many of which are still to be determined. Abnormal heart development results in a spectrum of congenital heart disease (CHD), occurring in isolation or part of a syndrome, and with or without a family history, implying a genetic basis in some individuals. In this project I investigated the molecular genetic basis of CHD, in 23 families with nonsyndromic CHD. Using autozygosity mapping, I initially investigated the molecular basis of CHD in a single large consanguineous family (CHD1), and

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23

Turner, Judith Ann Bornstein. "Visual perception in normal aging and Alzheimer's disease: Influences on picture naming and recognition." Case Western Reserve University School of Graduate Studies / OhioLINK, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=case1054834820.

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24

Saedon, Mahmud H. "Prediction, detection and suppression of cerebral microemboli associated with carotid disease." Thesis, University of Warwick, 2015. http://wrap.warwick.ac.uk/77581/.

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Background Transient cerebral microemboli detected by transcranial Doppler (TCD) have been demonstrated to be a reliable biomarker for short term stroke risk in two clinical settings; patients with carotid artery stenosis and those following carotid endarterectomy. Suppressing cerebral microemboli using TCD-directed antiplatelet treatment reduces risk of recurrent stroke. The association between classical cardiovascular risk factors and cerebral microemboli has not been studied. Furthermore, standard TCD method to detect cerebral microemboli is limited by lack of acoustic temporal bone window

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25

Dymott, Jane Alison. "Cardiovascular disease and type 2 diabetes mellitus : investigation of underlying mechanisms." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/2788/.

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Cardiovascular disease (CVD) remains the leading cause of death in the United Kingdom and is associated with a huge burden of morbidity. Within the group of cardiovascular diseases coronary artery disease (CAD) is the single largest cause of death. Death rates from CAD have been falling since the 1970s predominantly due to a reduction in the prevalence in major risk factors such as cigarette smoking. Type 2 diabetes mellitus (DM) is an important risk factor for CVD. Type 2 DM is increasing in prevalence and there is concern that this will contribute to an increase in the burden of CVD. Reducin

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26

Huwez, F. U. "Electrocardiography of the left ventricle in coronary artery disease and hypertrophy." Thesis, University of Glasgow, 1990. http://theses.gla.ac.uk/5665/.

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This thesis describes a series of studies which were undertaken to improve the diagnostic accuracy of the electrocardiogram (ECG), given the availability of computer assisted measurement techniques. Scalar 12 lead electrocardiograms have been recorded from over 200 cardiac patients recruited specifically for this study. Over 1,500 additional ECGs were available from normal and abnormal test populations. The ECG measurements were correlated with clinical, echocardiographic, radionuclide, coronary angiographic and contrast angiographic data of the left ventricle in order to meet the aims of the

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27

Mackenzie, Ruth M. "Oxidative stress in endothelial cells of patients with coronary artery disease." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/1531/.

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There is increasing evidence to support a role for vascular oxidative stress in the development of endothelial dysfunction and coronary artery disease (CAD). The prevalence of CAD in patients with type 2 diabetes (T2D) is more than ten times greater than in the general population and CAD patients with T2D display poorer clinical outcomes than those without. Previous investigations carried out within this laboratory have demonstrated endothelial dysfunction and elevated superoxide (O2-) production throughout the vessel wall in saphenous veins from patients with advanced CAD. However, the molecu

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28

Burns, David Meriton. "Epstein-Barr virus in the pathogenesis of post-transpant lymphoproliferative disease." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/5776/.

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Post-transplant lymphoproliferative disease (PTLD) is a life threatening complication of transplantation, often associated with the B-lymphotrophic Epstein-Barr virus (EBV). In order to further our understanding of the relationship between EBV infection and PTLD, a series of clinical and laboratory studies were undertaken. A multicentre United Kingdom study defined current outcomes and prognostic factors for patients with PTLD arising after solid organ transplant. A study to define incidence and risk factors for EBV reactivation and PTLD amongst patients undergoing allogeneic haematopoietic st

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Collins, Peter Francis. "Nutritional screening and nutritional support in chronic obstructive pulmonary disease (COPD)." Thesis, University of Southampton, 2012. https://eprints.soton.ac.uk/379646/.

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Malnutrition is a common problem in chronic obstructive pulmonary disease (COPD) and associated with poorer prognosis. Currently controversies surround the importance of nutritional intervention and how best to nutritionally manage those identified as at risk of malnutrition. Dietary advice (DA) and oral nutritional supplements (ONS) are two of the most common first line treatments for malnutrition in COPD but the evidence base for DA is lacking and for ONS appears uncertain. To date there have been no randomised trials comparing these two treatments in COPD. The aims of this thesis were three

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30

Inglis, Peter Ward. "Internal stipe necrosis of Agaricus bisporus : etiology and molecular genetic studies." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294300.

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31

Kotimäki, J. (Jouko). "Meniere's disease in Finland:an epidemiological and clinical study on occurrence, clinical picture and policy." Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:9514271130.

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Abstract The symptom complex originating from the inner ear, known as Meniere's disease, was studied especially from the epidemiologic point of view. A total of 442 patients' charts were retrospectively analysed in several hospital districts of Finland. The period of 1992-1996 was covered. The main focus was on the epidemiological assessment of the disease in Finland. To clarify the epidemiological figures, the validity of the diagnostic assessment was examined using the latest guidelines (1995) of the Committee on Hearing and Equilibrium of the American Academy of Otolaryngology - Head and Ne

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Walton, Georgia May. "Neutrophil migration and phagocytosis in chronic obstructive pulmonary disease." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8647/.

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COPD is a leading cause of morbidity and mortality. A wealth of data supports a role of the neutrophil in disease pathogenesis. Despite abundance of neutrophils in airway secretions, patients suffer recurrent respiratory infections and colonisation suggesting immune dysfunction. This thesis describes impaired migratory function of neutrophils from patients with COPD, but not Alpha-1 Anti-Trypsin Deficiency (AATD) where similar inflammation is present. This is a feature of all COPD disease phenotypes and may constitute an early disease alteration to cell function, or a factor that predisposes p

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33

Soofi, Abdulsalam. "Pathways that regulate renal development, fibrosis, and metabolic disease in mouse models." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/102838/.

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The kidney is an essential organ that maintains homeostasis, maintains water and mineral balance, and removes metabolic waste products from the body. In mammals, the kidney derives from the intermediate mesoderm (IM) and develops through a multistep process where undifferentiated mesenchyme is converted into a highly complex organ. Several transcriptional regulators, including the Pax2 gene, have been identified in the specification and maintenance of this multistep process. The Pax2 gene marks the IM shortly after gastrulation, when the mesoderm becomes compartmentalized into paraxial, interm

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Hassan-Smith, Ghaniah Zeb. "A study of classical and novel markers of disease in multiple sclerosis." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/6249/.

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Multiple sclerosis (MS) is a chronic inflammatory and degenerative condition of the Central Nervous System. Focal demyelinating lesions are its neuropathological hallmark, but widespread abnormalities found in otherwise “normal-appearing” tissue are better associated with disability outcomes. HMGB1 is a promiscuous sensor of cellular stress, acting as a link between sterile damage and innate immune mechanisms, with its extra-nuclear release producing diverse outcomes. We report novel findings of significantly increased HMGB1 expression throughout the brain tissue of MS vs. non-MS patients, par

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35

Hodgson, Paul David. "An in vitro model to study cartilage metabolism in Kashin-Beck disease." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/47396/.

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Kashin-Beck disease is endemic chronic degenerative osteoarthropathy whose main pathological changes occur in the growth plate and articular cartilage of human limbs and joints, where it is manifest as cartilage degeneration and necrosis. The effects of the disease on the growth plate therefore alter growth in children and can lead to growth arrest (short stature and limbs) and developmental deformities (crooked joints). In adulthood patients present with pain and deformity commonly affecting the hand, wrist, elbow, knee and ankle with radiological features and joint pattern involvement simila

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36

Arnold, Elisabeth. "The use of ambulatory oxygen in people with chronic obstructive pulmonary disease." Thesis, University of Southampton, 2012. https://eprints.soton.ac.uk/346058/.

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Chronic Obstructive Pulmonary Disease (COPD) is a chronic incurable respiratory condition. Part of the condition is increasing lung damage which reduces the passage of oxygen from the lungs into the bloodstream. This means that some people with COPD have abnormally low levels of oxygen in their arterial blood (hypoxaemia). Increasing the percentage of inspired oxygen has been shown to reduce mortality in people with severe hypoxaemia. Ambulatory oxygen (AO) has only been widely available for prescription in the UK since 2006, when the assessment and prescription of oxygen changed to a speciali

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Sambu, Nalyaka. "The clinical application of short thrombelastography platelet function testing in cardiovascular disease." Thesis, University of Southampton, 2013. https://eprints.soton.ac.uk/360441/.

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Platelets are key mediators in the pathogenesis of atherothrombosis. Antiplatelet therapy (APT) with aspirin and a P2Y12 receptor inhibitor is the cornerstone of treatment in patients with cardiovascular disease (CVD) and following percutaneous coronary intervention with stent implantation. Clinical studies have consistently demonstrated heterogeneity in responses to APT determined using ex vivo platelet function tests and reduced responsiveness is overwhelmingly associated with increased risk of adverse events including stent thrombosis (ST) and cardiovascular death. Nonetheless, assessment o

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Cooper, Nicola. "Phosphodiesterase 4 inhibitors for the treatment of inflammation associated with respiratory disease." Thesis, University of Greenwich, 2010. http://gala.gre.ac.uk/6364/.

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This submission for a PhD, by publication, which is based upon a series of original research studies published between 1998 and 2002 focuses on the selection of novel phosphodiesterase 4 (PDE4) inhibitors for the treatment of inflammation associated with respiratory diseases such as asthma and chronic obstructive pulmonary disease. A number of issues, relevant at the time, have been considered including: a) in vitro methods predictive of in vivo therapeutic index of anti-inflammatory efficacy over emetic side effects, b) in vivo methods for confirming therapeutic index and c) early confirmatio

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Preiss, David John. "The interplay between glycaemia and cardiovascular disease." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/3038/.

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Numerous large clinical trials of cardiovascular risk lowering agents have been conducted in the hope of reducing the excess cardiovascular risk found in patients with diabetes mellitus. However, the relationship between glucose and cardiovascular disease remains complex and various areas require further study. Even in patients with diabetes, an individual’s cardiovascular risk is highly variable depending on other clinical characteristics, the assumption that glucose is a continuous risk factor has often been based on weak evidence from relatively short studies, the effect of commonly used ca

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McNelis, Joanne. "Dehydroepiandrosterone and dehydroepiandrosterone sulphotransferase activity and expression in human disease." Thesis, University of Birmingham, 2009. http://etheses.bham.ac.uk//id/eprint/1061/.

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The adrenal steroid dehydroepiandrosterone (DHEA) and its sulphate ester, DHEAS are the most abundant circulating steroid hormones in humans. Uncongugated DHEA predominately exerts its effects via its downstream conversion to active sex steroids in peripheral target tissues. In contrast the conversion of DHEAS to androgens first requires cleavage of the sulfate group, catalysed by the microsomal enzyme steroid sulfatase (STS). Conversely, DHEA is converted to inactive DHEAS by the activity of the cytosolic enzyme DHEA sulphotransferase (SULT2A1). However, in addition, evidence is growing that

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Holt, Tim A. "Use of primary care data for identifying individuals at risk of cardiovascular disease." Thesis, University of Warwick, 2009. http://wrap.warwick.ac.uk/3727/.

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The aim of this research was to explore the potential of routinely collected primary care data to support the identification of individuals for cardiovascular risk reduction. The work involved a systematic literature review of reminder interventions operating at the point of care; a randomised controlled trial of a novel software tool to facilitate the targeting of individuals at risk of cardiovascular disease; and an exploration of qualitative issues relevant to the challenge of cardiovascular risk reduction in current practice. The Systematic review resulted in a narrative synthesis and a me

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Hart, Peter. "Comparison of the immune response to typhoid fever and invasive nontyphoidal Salmonella disease." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/6023/.

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Nontyphoidal \(Salmonella\) is strongly associated with HIV infection, whereas there is a negative association between HIV and typhoid fever. To investigate this phenomenon, we explored humoral and cytokine responses in HIV-infected and uninfected blood and sera against \(S.\) Typhimurium and \(S.\) Typhi, finding that HIV-infected sera had significantly impaired bactericidal and opsonic activity against \(S.\) Typhi compared with HIV-uninfected sera. We observed dysregulated cytokine responses in blood from HIV-infected individuals after Salmonella stimulation, with RANTES levels being modula

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Nijm, Johnny. "Inflammation and cortisol response i coronary artery disease." Doctoral thesis, Linköpings universitet, Institutionen för medicin och hälsa, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-15978.

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Atherosclerosis is characterized by a chronic inflammation, involving autoimmune components, in the arterial wall. An increase in proinflammatory activity relative to anti-inflammatory activity is considered to cause a progression of the disease towards plaque instability and risk of atherothrombotic events, such as acute coronary syndrome (ACS). Cortisol, the end product of the hypothalamus-pituitary-adrenal (HPA) axis, is a powerful endogenous anti-inflammatory mediator. Disturbances in the HPA axis have been reported in chronic inflammatory/autoimmune diseases, like rheumatoid arthritis. Th

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Walsh, Diana Maria. "Exome sequencing and human disease : the molecular characterisation of genetic disorders." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6664/.

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Since the completion of the human genome project in 2001, the field of genomics has advanced exponentially, largely due in part to the introduction of next generation sequencing (NGS); a technique that has revolutionised the ways in which genetic disease is investigated. NGS enables the simultaneous sequencing of multiple reads in parallel, which provides researchers with the opportunity to interrogate vast numbers of candidate genes in order to establish the genetic eitiology and key components of disease. Exome sequencing in particular offers an efficient method to investigate disease, as th

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Styles, Darrel Keith. "Psittacid herpesvirus associated with internal papillomatous disease and other tumors in psittacine birds." Texas A&M University, 2005. http://hdl.handle.net/1969.1/2646.

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Internal papillomatous disease (IPD) is characterized by mucosal papillomas occurring primarily in the oral cavity and cloaca of Neotropical parrots. These lesions can cause considerable morbidity, and in some cases result in mortality. Efforts to demonstrate papillomavirus DNA or proteins in the lesions have been largely unsuccessful. However, increasing evidence suggests that mucosal papillomas may contain psittacid herpesviruses (PsHVs). In this study, PsHV 1 genotype 1, 2, and 3 DNA was found in 100% of mucosal papillomas from 30 Neotropical parrots by PCR using PsHV specific primers. Howe

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McCoy, G. F. "The role of vibration emission in the diagnosis of internal diseases of the knee." Thesis, Queen's University Belfast, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233274.

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Curran, Samuel Arion. "Pathogenesis of cardiovascular disease in the presence and absence of rheumatoid arthritis." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3849/.

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Rheumatoid arthritis (RA) is a chronic inflammatory disease that although primarily affecting the joints is recognised as a systemic disease with a variety of co-morbidities. One such co-morbidity is cardiovascular disease (CVD) and patients with RA are at a two-fold increased risk of developing CVD compared to the general population. Indeed, CVD, principally as a result of atherosclerosis, is recognised as the leading cause of death in RA patients. In this study the vascular adventitia and serum samples from patients with co-existing RA and CVD were investigated to identify factors that could

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McKay, Bounford Kirsten Elizabeth. "Investigations into the genetic causes of liver disease using molecular genetic technologies." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/7101/.

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DNA sequencing technologies have developed quickly in the last decade, and new methodologies have moved into clinical practice. These can been used to investigate genetic causes of neonatal cholestasis. Neonatal cholestasis can be life-threatening and has a varied etiology. In chapter 3, a targeted next generation sequencing (tNGS) assay was designed and assessed for suitability for detection of known mutations in genes associated with cholestasis. In chapter 4, this was used to screen over 200 infants presenting with liver disease for mutations in the (ATP8B1), (ABCB11), (ABCB4), (NPC1), (NPC

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Lewthwaite, Alistair John. "A clinical and molecular genetic study into familial and sporadic Parkinson’s Disease." Thesis, University of Birmingham, 2009. http://etheses.bham.ac.uk//id/eprint/576/.

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Parkinson’s disease (PD) is a neurodegenerative disease which causes tremor, muscular rigidity and bradykinesia (slowness of initiation of voluntary movement with progressive reduction in speed and amplitude of repetitive actions). Although the underlying causes remain unknown, there is evidence that genetic factors play an important role in the disease process. In this thesis I investigated the role of a recently identified hereditary PD gene leucine rich repeat kinase 2 (LRRK2) in PD in the United Kingdom (UK). In this thesis I have confirmed the importance of pathogenic LRRK2 mutations in U

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Mitchell, David Ross. "Environmental factors relevant to the rising incidence of gastro-oesophageal reflux disease." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/30793/.

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Gastro-oesophageal reflux disease (GORD) is one of the commonest chronic conditions in the western world with a reported prevalence of 10-20% in Europe and the USA. The disease involves an interplay between factors promoting reflux of gastric juice and failure of defensive forces designed to neutralise the resulting acidity. Transient lower oesophageal relaxations, the acid pocket and the presence of a hiatus hernia are important factors. Acid reflux can cause benign oesophageal injury, including oesophagitis, oesophageal ulceration and peptic structuring, as well as malignant complications li

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