Academic literature on the topic 'International Six Days Trial'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'International Six Days Trial.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Journal articles on the topic "International Six Days Trial"
1
Lockwood, Kylee J., Katherine E. Harding, Jude N. Boyd, and Nicholas F. Taylor. "Predischarge home visits after hip fracture: a randomized controlled trial." Clinical Rehabilitation 33, no. 4 (January 14, 2019): 681–92. http://dx.doi.org/10.1177/0269215518823256.
Full textAbstract:
Objective: The objective of this study is to investigate whether home assessment visits prior to hospital discharge for patients recovering from hip fracture reduce falls and prevent hospital readmissions, within the first 30 days and six months after discharge home. Design: A randomized controlled trial was conducted. Setting: The study setting included hospital wards and the community. Participants: The study included adults 50 years and over recovering from hip fracture ( n = 77). Intervention: Both groups received inpatient rehabilitation and hospital-based discharge planning. In addition, the intervention group received a home assessment visit by an occupational therapist prior to discharge from hospital. Main measures: Primary outcomes were falls and hospital readmissions. Secondary outcome measures included Functional Independence Measure, Functional Autonomy Measurement Scale, Nottingham Extended Activities of Daily Living Scale, EuroQol five dimension scale questionnaire and Falls Efficacy Scale-International. Results: The intervention group had fewer hospital readmissions in the first 30 days compared to the control group (intervention n = 1, control n = 10; odds ratio (OR) 12.9, 95% confidence interval (CI) 1.5 to 99.2). The intervention group was observed to have fewer falls than controls in the 30 days after discharge (intervention n = 6, control n = 14; incidence rate ratio (IRR) = 0.41, 95% CI 0.15 to 1.11). Between-group differences favoured the intervention group for functional independence at six months (11.2 units, 95% CI 4.2 to 18.2). There were no other between-group differences. Conclusion: Home assessment visits by occupational therapists prior to hospital discharge for patients recovering from hip fracture reduced the number of readmissions to hospital, increased functional independence at six months and may have reduced the risk of falls in the first 30 days after discharge.
2
Norman, John G., Stephen Brealey, Ada Keding, David Torgerson, and Amar Rangan. "Does time to surgery affect patient-reported outcome in proximal humeral fractures? A subanalysis of the PROFHER randomized clinical trial." Bone & Joint Journal 102-B, no. 1 (January 2020): 33–41. http://dx.doi.org/10.1302/0301-620x.102b1.bjj-2020-0546.r1.
Full textAbstract:
Aims The aim of this study was to explore whether time to surgery affects functional outcome in displaced proximal humeral fractures Methods A total of 250 patients presenting within three weeks of sustaining a displaced proximal humeral fracture involving the surgical neck were recruited at 32 acute NHS hospitals in the United Kingdom between September 2008 and April 2011. Of the 125 participants, 109 received surgery (fracture fixation or humeral head replacement) as per randomization. Data were included for 101 and 67 participants at six-month and five-year follow-up, respectively. Oxford Shoulder Scores (OSS) collected at six, 12, and 24 months and at three, four, and five years following randomization was plotted against time to surgery. Long-term recovery was explored by plotting six-month scores against five-year scores and agreement was illustrated with a Bland-Altman plot. Results The mean time from initial trauma to surgery was 10.5 days (1 to 33). Earlier surgical intervention did not improve OSS throughout follow-up, nor when stratified by participant age (< 65 years vs ≥ 65 years) and fracture severity (one- and two-part vs three- and four-part fractures). Participants managed later than reported international averages (three days in the United States and Germany, eight days in the United Kingdom) did not have worse outcomes. At five-year follow-up, 50 participants (76%) had the same or improved OSS compared with six months (six-month mean OSS 35.8 (SD 10.0); five-year mean OSS 40.1 (SD 9.1); r = 0.613). A Bland-Altman plot demonstrated a positive mean difference (3.3 OSS points (SD 7.92)) with wide 95% limits of agreement (-12.2 and 18.8 points). Conclusion Timing of surgery did not affect OSS at any stage of follow-up, irrespective of age or fracture type. Most participants had maximum functional outcome at six months that was maintained at five years. These findings may help guide providers of trauma services on surgical prioritization. Cite this article: Bone Joint J 2020;102-B(1):33–41
3
Birlea, Marius, Sophie Penning, Kyle Callahan, and Jean Schoenen. "Efficacy and safety of external trigeminal neurostimulation in the prevention of chronic migraine: An open-label trial." Cephalalgia Reports 2 (January 1, 2019): 251581631985662. http://dx.doi.org/10.1177/2515816319856625.
Full textAbstract:
Objective: This trial explored the therapeutic utility and safety of external trigeminal neurostimulation (eTNS) as a preventive treatment in patients suffering from chronic migraine (CM). Methods: It was a monocenter, prospective, open-label, pilot trial conducted at the University of Colorado, Anschutz Medical Campus (Aurora, CO, USA). Participants were adult patients with a history of CM meeting International Classification of Headache Disorder-3 beta (2013) diagnostic criteria with or without medication overuse. After a 1-month baseline period, the patients still fulfilling the inclusion criteria applied at least one daily 20-min session of eTNS for 3 months. Primary outcomes were mean monthly changes in frequency of headache days and in overall acute headache medication intake. Results: Eighty patients were assessed for eligibility, 73 were included in the baseline period after which 58 entered the treatment period and were included in the intention-to-treat analysis. Compared to baseline, frequency of headache days decreased by −3.12 days (−16.21%, p < 0.001) and acute medication intake decreased from 26.33 to 18.22 (−30.81%, p < 0.001) during the third month of treatment. Twenty-six patients reported 47 minor adverse events, of which only 2 were related to the use of the device (skin irritation under the electrode and headache worsening with vertigo). Conclusions: This trial suggests that eTNS is safe and effective as prophylactic treatment for CM and indicates that a randomized sham-controlled trial is worthwhile. Trial registration: ClinicalTrials.gov (identifier: NCT02342743).
4
Bolis, Giorgio, Giovanna Scarfone, Gianpiero Polverino, Francesco Raspagliesi, Saverio Tateo, Giovanni Richiardi, Mauro Melpignano, et al. "Paclitaxel 175 or 225 mg per Meters Squared With Carboplatin in Advanced Ovarian Cancer: A Randomized Trial." Journal of Clinical Oncology 22, no. 4 (February 15, 2004): 686–90. http://dx.doi.org/10.1200/jco.2004.03.017.
Full textAbstract:
Purpose To analyze the effect of different doses of paclitaxel with fixed doses of carboplatin in the treatment of ovarian cancer. Patients and Methods Patients with histologically confirmed epithelial ovarian cancer, International Federation of Gynecology and Obstetrics stages IIB to IV, were eligible for this randomized, multicenter study. Women were randomly assigned to treatment with (1) carboplatin at the dose (in milligrams) corresponding to the following formula: target area under the free carboplatin plasma concentration versus time curve (AUC) = 6 × (glomerular filtration rate + 25) mg/m2 (AUC6) plus paclitaxel 175 mg/m2 for six cycles every 21 days or (2) carboplatin AUC6 plus paclitaxel 225 mg/m2 for six cycles every 21 days. A total of 502 women entered the study. Results Pathologic complete response was documented in 132 patients (63.8%) in the 175 mg/m2 group and in 127 cases (55.7%) in the 225 mg/m2 group (χ2 P = .090). The 4-year progression-free survival rate was 41.5% (SE = 3.5) in the 175-mg group and 39.2% (SE = 3.5) in the 225-mg group. The corresponding 4-year survival rates were 46.2% (based on 115 deaths) and 47.3% (based on 113 deaths), respectively. Conclusion This randomized trial suggests that paclitaxel 175 mg/m2 plus carboplatin AUC6 is the schedule with a more favorable profile than paclitaxel 225 mg/m2 plus carboplatin AUC6.
5
Conte, P. F., M. Bruzzone, S. Chiara, M. R. Sertoli, M. G. Daga, A. Rubagotti, A. Conio, M. Ruvolo, R. Rosso, and L. Santi. "A randomized trial comparing cisplatin plus cyclophosphamide versus cisplatin, doxorubicin, and cyclophosphamide in advanced ovarian cancer." Journal of Clinical Oncology 4, no. 6 (June 1986): 965–71. http://dx.doi.org/10.1200/jco.1986.4.6.965.
Full textAbstract:
After primary surgery, 125 patients with epithelial ovarian cancer (International Federation of Gynaecology and Obstetrics [FIGO] 1c + IIb + IIc = 22 patients, FIGO III = 82 patients, FIGO IV = 21 patients) were randomly allocated to receive PC (cisplatin 50 mg/m2 + cyclophosphamide 600 mg/m2 on day 1 every 28 days) (corrected) or PAC (PC + doxorubicin 45 mg/m2). After six cycles, patients clinically disease-free or with resectable residual disease were submitted to second-look surgery. After restaging, patients in surgical complete response (CR) stopped treatment while those responding partially (PR) received six more courses; patients whose disease progressed were excluded from the study. Among patients with measurable disease, the following clinical response rates were observed: PC = 20% CR, 34.3% PR, 14.3% stable disease, and 31.4% progression; PAC = 40.6% CR, 15.6% PR, 12.5% stable disease, and 31.3% progression. In the 75 patients submitted to second look, the results have been the following: PC = 39.5% CR, 36.8% PR, 7.9% stable disease, and 15.8% progression; PAC = 62.2% CR, 18.9% PR, 10.8% stable disease, and 8.1% progression. The difference in surgical complete response in favor of the PAC regimen is significant (P less than .05). Median survival and progression-free survival were 800 and 400 days, respectively, for PAC arm; median survival and progression-free survival were 680 and 380 days, respectively, for PC. These differences are not significant. Probability of survival was affected by FIGO stage, amount of residual disease, histology, performance status, and response at second look, while no influence was observed according to grade of tumor differentiation and age. Our results demonstrate the usefulness of doxorubicin in terms of surgical CR.
6
Meister, Franziska Alexandra, Zoltan Czigany, Jan Bednarsch, Jörg Böcker, Iakovos Amygdalos, Daniel Antonio Morales Santana, Katharina Rietzler, et al. "Hypothermic Oxygenated Machine Perfusion of Extended Criteria Kidney Allografts from Brain Dead Donors: Protocol for a Prospective Pilot Study." JMIR Research Protocols 8, no. 10 (October 14, 2019): e14622. http://dx.doi.org/10.2196/14622.
Full textAbstract:
Background Kidney transplantation is the only curative treatment option for end-stage renal disease. The unavailability of adequate organs for transplantation has resulted in a substantial organ shortage. As such, kidney donor allografts that would have previously been deemed unsuitable for transplantation have become an essential organ pool of extended criteria donor allografts that are now routinely being transplanted on a global scale. However, these extended criteria donor allografts are associated with significant graft-related complications. As a result, hypothermic oxygenated machine perfusion (HOPE) has emerged as a powerful, novel technique in organ preservation, and it has recently been tested in preclinical trials in kidney transplantation. In addition, HOPE has already provided promising results in a few clinical series of liver transplantations where the liver was donated after cardiac death. Objective The present trial is an investigator-initiated prospective pilot study on the effects of HOPE on extended criteria donor allografts donated after brain death and used in kidney transplantation. Methods A total of 15 kidney allografts with defined inclusion/exclusion criteria will be submitted to two hours of HOPE via the renal artery before implantation, and are going to be compared to a case-matched group of 30 patients (1:2 matching) who had kidneys transplanted after conventional cold storage. Primary (posttransplant dialysis within 7 days) and secondary (postoperative complications, early graft function, duration of hospital and intensive care unit stay, and six-month graft survival) endpoints will be analyzed within a six-month follow-up period. The extent of ischemia-reperfusion injury will be assessed using kidney tissue, perfusate, and serum samples taken during the perioperative phase of kidney transplantation Results The results of this trial are expected in the first quarter of 2020 and will be presented at national and international scientific meetings and published in international peer-reviewed medical journals. The trial was funded in the third quarter of 2017 and patient enrollment is currently ongoing. Conclusions This prospective study is designed to explore the effects of HOPE on extended criteria donor kidney allografts donated after brain death. The present report represents the preresults phase. Trial Registration Clinicaltrials.gov NCT03378817; https://clinicaltrials.gov/ct2/show/NCT03378817
7
Rousseau, P., F. Flamant, E. Quintana, P. A. Voute, and J. C. Gentet. "Primary chemotherapy in rhabdomyosarcomas and other malignant mesenchymal tumors of the orbit: results of the International Society of Pediatric Oncology MMT 84 Study." Journal of Clinical Oncology 12, no. 3 (March 1994): 516–21. http://dx.doi.org/10.1200/jco.1994.12.3.516.
Full textAbstract:
PURPOSE The MMT 84 multicentric prospective trial of the International Society of Pediatric Oncology (SIOP) was designed to (1) test the effectiveness of ifosfamide 3 g/m2 on days 1 and 2, vincristine 1.5 mg/m2 on days 1 and 14, and dactinomycin 0.9 mg/m2 on days 1 and 2 (IVA) repeated every 21 days; and (2) reduce late effects of treatment by reserving radiation therapy to the primary site for patients not achieving a complete response (CR) to primary chemotherapy. MATERIALS AND METHODS Between 1984 and 1989, the MMT 84 study registered 34 children with nonmetastatic rhabdomyosarcomas (RMSs) and other malignant mesenchymal tumors (MMTs) of the orbit in this trial. RESULTS The 4-year event-free survival rate is 62% +/- 9% (SD) and the 4-year survival rate 86% +/- 7% (SD). A total of 11 local recurrences occurred, 10 among 22 patients treated without initial radiation. Salvage of local failure was achieved in nine of 11 patients with the use of radiation and additional chemotherapy, but three later developed distant metastases and two have died. One isolated regional lymph node failure has occurred, while no patient relapsed with isolated distant metastases. Six of 12 patients who failed are alive with no evidence of disease from 16 to 50 months after relapse. The treatment was well tolerated in all patients, except for one with renal tubular acidosis and one who died of cardiotoxicity. Twelve patients remain in first remission without the use of radiation to the primary tumor from 27 to 84 months. CONCLUSION Despite a higher incidence of local recurrence when treated by primary chemotherapy, early survival rates were not compromised and a significant number of patients avoided the late effects of radiation. However, longer follow-up is required to assess the ultimate outcome of patients treated in this manner.
8
Gnanenthiran, Sonali Rukshana, Claudio Borghi, Dylan Burger, Fadi Charchar, Neil R. Poulter, Markus P. Schlaich, Ulrike Muscha Steckelings, et al. "Prospective meta-analysis protocol on randomised trials of renin–angiotensin system inhibitors in patients with COVID-19: an initiative of the International Society of Hypertension." BMJ Open 11, no. 2 (February 2021): e043625. http://dx.doi.org/10.1136/bmjopen-2020-043625.
Full textAbstract:
IntroductionWhether ACE inhibitors (ACEi) or angiotensin II receptor blocker (ARB) therapy should be continued, initiated or ceased in patients with COVID-19 is uncertain. Given the widespread use of ACEi/ARBs worldwide, guidance on the use of these drugs is urgently needed. This prospective meta-analysis aims to pool data from randomised controlled trials (RCTs) to assess the safety and efficacy of ACEi/ARB therapy in adults infected with SARS-CoV-2.Methods and analysisRCTs will be eligible if they compare patients with COVID-19 randomised to ACEi/ARB continuation or commencement versuss no ACEi/ARB therapy; study duration ≥14 days; recruitment completed between March 2020 and May 2021. The primary outcome will be all-cause mortality at ≤30 days. Secondary outcomes will include mechanical ventilation, admission to intensive care or cardiovascular events at short-term follow-up (≤30 days) and all-cause mortality at longer-term follow-up (>1 month). Prespecified subgroup analyses will assess the effect of sex; age; comorbidities; smoking status; ethnicity; country of origin on all-cause mortality. A search of ClinicalTrials.gov has been performed, which will be followed by a formal search of trial registers, preprint servers, MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials to identify RCTs that meet inclusion criteria. To date, a search of ClinicalTrials.gov identified 21 potentially eligible trials for this meta-analysis. We will request trial investigators/sponsors to contribute standardised grouped tabular outcome data.Ethics and disseminationEthics approval and informed consent will be the responsibility of the individual RCTs. Dissemination of results will occur by peer-reviewed publication. The results of our analysis can inform public health policy and clinical decision making regarding ACEi/ARB use in patients with COVID-19 on a global scale.
9
Jayant, Kumar, Isabella Reccia, Francesco Virdis, and A. M. James Shapiro. "The Role of Normothermic Perfusion in Liver Transplantation (TRaNsIT Study): A Systematic Review of Preliminary Studies." HPB Surgery 2018 (May 17, 2018): 1–14. http://dx.doi.org/10.1155/2018/6360423.
Full textAbstract:
Introduction. The success of liver transplantation has been limited by the unavailability of suitable donor livers. The current organ preservation technique, i.e., static cold storage (SCS), is not suitable for marginal organs. Alternatively, normothermic machine perfusion (NMP) promises to recreate the physiological environment and hence holds promise for the better organ preservation. The objective of this systematic review is to provide an overview of the safety, benefits, and insight into the other potential useful parameters of NMP in the liver preservation. Material and Methods. We searched the current literature following registration in the International Prospective Register of Systematic Reviews (PROSPERO) with registration number CRD42018086034 for prospective trials comparing the role of NMP device to SCS in liver transplant by searching the PubMed, EMBASE, Cochrane, BIOSIS, Crossref, and Scopus databases and clinical trial registry. Results. The literature search identified five prospective clinical trials (four being early phase single institutional and single randomized multi-institutional) comparing 187 donor livers on NMP device to 273 donor livers on SCS. The primary outcome of interest was to assess the safety and graft survival at day 30 after transplant following NMP of the donor liver. Secondary outcomes included were early allograft dysfunction (EAD) in the first seven days; serum measures of liver functions as bilirubin, aspartate aminotransferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), and international normalized ratio (INR) on days 1–7; major complications as defined by a Clavien-Dindo score ≥ 3; and patient and graft survival and biliary complications at six months. The peaked median AST level between days 1 and 7 in the five trials was 417–1252 U/L (range 84–15009 U/L) while on NMP and 839–1474 U/L (range 153–8786 U/L) in SCS group. The median bilirubin level on day 7 ranged within 25–79 µmol/L (range 8–344 µmol/l) and 30–47.53 µmol/l (range 9–340 µmol/l) in NMP and SCS groups, respectively. A single case of PNF was reported in NMP group in the randomized trial while none of the other preliminary studies reported any in either group. There was intertrial variability in EAD which ranged within 15–56% in NMP group while being within 23–37% in SCS group. Biliary complications observed in NMP group ranged from 0 to 20%. Single device malfunction was reported in randomized controlled trial leading to renouncement of transplant while none of the other trials reported any machine failure, although two user related device errors inadvertent were reported. Conclusion. This review outlines that NMP not only demonstrated safety and efficacy but also provided the favourable environment of organ preservation, repair, and viability assessment to donor liver prior to the transplantation with low rate of posttransplantation complication as PNF, EAD, and biliary complication; however further studies are needed to broaden our horizon.
10
Loehrer, P. J., L. H. Einhorn, P. J. Elson, E. D. Crawford, P. Kuebler, I. Tannock, D. Raghavan, R. Stuart-Harris, M. F. Sarosdy, and B. A. Lowe. "A randomized comparison of cisplatin alone or in combination with methotrexate, vinblastine, and doxorubicin in patients with metastatic urothelial carcinoma: a cooperative group study." Journal of Clinical Oncology 10, no. 7 (July 1992): 1066–73. http://dx.doi.org/10.1200/jco.1992.10.7.1066.
Full textAbstract:
PURPOSE A prospective randomized trial was performed to determine if the addition of methotrexate, vinblastine, and doxorubicin to cisplatin (M-VAC) imparted a response rate or a survival advantage over single-agent cisplatin in patients with advanced urothelial carcinoma. PATIENTS AND METHODS From October 1984 through May 1989, 269 patients with advanced urothelial carcinoma were entered onto this international intergroup trial and randomized to receive intravenous (IV) cisplatin (70 mg/m2) alone or with methotrexate (30 mg/m2 on days 1, 15, 22), vinblastine (3 mg/m2 on days 2, 15, 22) plus doxorubicin (30 mg/m2 on day 2). Cycles were repeated every 28 days until tumor progression or a maximum of six cycles. There were 246 fully assessable patients of whom 126 were randomized to cisplatin alone and 120 were randomized to the M-VAC regimen. RESULTS As expected, the M-VAC regimen was associated with a greater toxicity, especially leukopenia, mucositis, granulocytopenic fever, and drug-related mortality. Response rates were superior for the M-VAC regimen compared with single-agent cisplatin (39% v 12%; P less than .0001). Similarly, the progression-free survival (10.0 v 4.3 months) and overall survival (12.5 v 8.2 months) were significantly greater for the combined therapy arm. CONCLUSION Although a more toxic regimen, we found M-VAC to be superior to single-agent cisplatin with respect to response rate, duration of remission, and overall survival in patients with advanced urothelial carcinoma.
Dissertations / Theses on the topic "International Six Days Trial"
1
Knotová, Vaicová Barbora. "Vítěz Mezinárodní motocyklové šestidenní. Biografie Josefa Rabase." Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-447167.
Full textAbstract:
Master thesis focuses on the life story of Josef Rabas, the multiple world champion of the International six days enduro competition. Thesis uses biographical research together with oral history method to capture the storytelling of his life journey. The emphasis is placed not only on the chronological description of the person's life but also on the explanation and understanding of contextual impacts of the period in which he lived. Another followed line is the explanation of the chosen career path where we search for possible contradiction to family's tradition. Besides being the motorcycle racer, Josef is a grandson of the academic painter and renowned artist Václav Rabas and a son of Jan Rabas, a lawyer and one of the signatories of the "Dva tisíce slov" document. Therefore, we also emphasized the family's socio-political context.
Books on the topic "International Six Days Trial"
1
McColm, Jim. Six days in May: The Scottish six days trial 1970-1994. West Calder, Lothian: Hugh K. Clarkson, 1995.
Find full text
2
Orkaby, Asher. Beyond the Arab Cold War. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780190618445.001.0001.
Full textAbstract:
Beyond the Arab Cold War brings the Yemen Civil War (1962–68) to the forefront of modern Middle East history, in a comprehensive account that features multilingual and multinational archives and oral histories. Throughout six years of major conflict Yemen sat at the crossroads of regional and international conflict as dozens of countries, international organizations, and individuals intervened in the local South Arabian civil war. Yemen was a showcase for a new era of UN and Red Cross peacekeeping, clandestine activity, Egypt’s counterinsurgency, and one of the first large-scale uses of poison gas since World War I. Events in Yemen were not dominated by a single power, nor were they sole products of US-Soviet or Saudi-Egyptian Arab Cold War rivalry. Rather, during the 1960s Yemen was transformed into an arena of global conflict whose ensuing chaos tore down the walls of centuries of religious rule and isolation and laid the groundwork for the next half century of Yemeni history. The end of the Yemen Civil War marked the end of both Egyptian President Nasser’s Arab nationalist colonial expansion and the British Empire in the Middle East, two of the most dominant regional forces. The legacy of the eventual northern tribal defeat and the compromised establishment of a weak and decentralized republic are at the core of modern-day conflicts in South Arabia.
3
Weill, Sharon, Kim Thuy Seelinger, and Kerstin Bree Carlson, eds. The President on Trial. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198858621.001.0001.
Full textAbstract:
By some accounts, the trial and conviction of Hissène Habré is the most significant achievement global criminal justice has enjoyed in the past decade. Simply creating a court and commencing a trial against a deposed head of state was an extraordinary success. The ad hoc tribunal set up in Senegal exceeded expectations, working on time, within budget, with no murdered witnesses or self-dealing officials. This achievement is particularly meaningful in the current climate, where we are witnessing a ‘backlash’ against international criminal justice. This book presents the Habré trial and its impact using a novel structure of first person accounts and academic analysis, presenting both local and international perspectives through distinct but inter-locking parts. It offers empirical source material followed by expert analysis designed to bring the reader closer both to the construction and work of the Extraordinary African Chambers (EAC) as well as wider themes of international criminal law. We the editors followed the case from 2015 onwards. We made several trips to Dakar in order to interview a spectrum of actors associated with the EAC. Convinced of the trial’s significance, concerned that it would remain understudied by an anglophone audience, and wishing to bring local experience and knowledge out of Dakar and to the world, we conceived of the book’s particular structure. This is the genesis of the twenty-six actor testimonials that constitute Part I, the heart of the book. In Part II of the book we situate the Habré case in its larger context through seventeen contributions of leading academics and experts in the field of ICL.
4
Autora, Grupa. PSYCHOLOGY IN THE WORLD OF SCIENCE - 16th Days of Applied Psychology. Filozofski fakultet Niš, 2021. http://dx.doi.org/10.46630/dpp.2021.
Full textAbstract:
The International Thematic Proceedia titled „Psychology in the world of science” is a publication from the 16th International Conference “Days of Applied Psychology” held on September 25th & 26th 2020 at the Faculty of Philosophy, University of Niš. This is a traditional annual nonprofit conference which has been organized since 2005 by the Department of Psychology of the Faculty of Philosophy, University of Niš, with the support and co-financing of the Ministry of Education, Science and Technological Development of the Republic of Serbia. The conference started with the idea of gathering researchers and practitioners who discuss the link between science and practice in different psychological areas. From the very start, this gathering has welcomed international participants, and year after year this number is on the rise. This scientific publication contains 18 peer-reviewed articles which can be classified as original scientific papers and as review papers. The authors of these manuscripts come from six countries: Portugal, Bosnia and Herzegovina, Slovenia, Bulgaria, Turkey, and Republic of Serbia.
5
William A, Schabas. Part 5 Investigation and Prosecution: Enquête Et Poursuites, Art.57 Functions and powers of the Pre-Trial Chamber/Fonctions et pouvoirs de la chambre préliminaire. Oxford University Press, 2016. http://dx.doi.org/10.1093/law/9780198739777.003.0062.
Full textAbstract:
This chapter comments on Article 57 of the Rome Statute of the International Criminal Court. Article 57 sets out the functions and powers of the Pre-Trial Chamber. Article 39 of the Rome Statute established the existence of the Pre-Trial Chamber. It required the creation of a Pre-Trial Division of not less than six judges, and was to be composed predominantly of judges with criminal trial experience. The Pre-Trial Chamber is ‘responsible for any matter, request or information arising out of the situation assigned to it’, subject to the authority of the President of the Pre-Trial Division to assign a matter, request, or information to another Pre-Trial Chamber ‘in the interests of the administration of justice’.
6
Young, Benjamin. Classes of Antiretrovirals. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190493097.003.0019.
Full textAbstract:
Results of the randomized, international INSIGHT START clinical trial provide definitive proof of the benefit of antiretroviral therapy initiation in asymptomatic individuals with CD4+ counts greater than 500 cells/mm3. There are six different classes of antiretroviral agents: two types of reverse transcriptase inhibitors, two types of entry inhibitors, one class of inhibitors of HIV protease, and one class of inhibitors of HIV integrase. Combination antiretroviral therapy is recommended for all people living with HIV. The primary goal of combination antiretroviral therapy is to achieve viral suppression. Each antiretroviral class targets a unique step in the replication cycle of HIV-1.
7
Webb, Jason A., and Arif H. Kamal. Palliative Oxygen Versus Room Air for Refractory Dyspnea (DRAFT). Edited by Nathan A. Gray and Thomas W. LeBlanc. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190658618.003.0017.
Full textAbstract:
Palliative oxygen therapy is used for treating dyspnea in patients with cancer and advanced cardiopulmonary diseases, however, small trials have suggested that circulating air may be just as effective. This international, multicenter, randomized controlled trial compared oxygen versus room air delivered by a nasal cannula for relief of dyspnea for patients with any life-limiting illness. Patients were adults >18 years of age, with PaO2 > 7.3kPa, on optimized therapies for their illness, and an expected survival of >1 month. The study demonstrated no clinically significant symptomatic benefit of palliative oxygen versus room air delivered via nasal cannula for seven days in patients with life-limiting illnesses and refractory dyspnea.
8
Lawlor, Peter. Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients (DRAFT). Edited by Nathan A. Gray and Thomas W. LeBlanc. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190658618.003.0011.
Full textAbstract:
This chapter, reports on a prospectively matched controlled trial in which Inouye et al. examined the comparative effectiveness of a targeted multicomponent strategy for reducing the risk of delirium with that of usual standard care. The six targeted baseline risk factors in delirium-free patients admitted to a medical service in a teaching hospital were cognitive impairment, sleep deprivation, immobility, visual impairment, hearing impairment, and dehydration. Using standardized interventions for each of these when present, 42/426 (9.9%) of those in the intervention group had a first-incident episode of delirium compared to 64/426 (15%) in the usual care group, representing a statistically significant reduction of approximately 33% in first-incident episodes of delirium. The number of patient-days with delirium (105 vs. 161) and delirium episodes (62 vs. 90) were significantly lower in the intervention group. Primary prevention of delirium was effective.
9
François, Dubuisson, and Koutroulis Vaios. Part 1 The Cold War Era (1945–89), 16 The Yom Kippur War—1973. Oxford University Press, 2018. http://dx.doi.org/10.1093/law/9780198784357.003.0016.
Full textAbstract:
This contribution discusses the hostilities that opposed Israel against Egypt, Syria and the armed forces of other Arab states, which took place in October 1973. After setting out the context of this confrontation, which is directly linked to the 1967 Six Days War, it presents the legal positions of the main protagonists (Israel, Egypt, Syria) as well as those of third states and international organizations. The third section examines the legality of this resort to force under jus ad bellum and concludes that the military operations on behalf of the Arab states can be justified as an exercise of the right to self-defence. Finally, the conclusions discuss the limited precedential value of this specific incident with respect to the interpretation of the prohibition to use force in international relations.
Book chapters on the topic "International Six Days Trial"
1
"Chapter Six. The Judiciary: Pre-Trial, Trial And Appeals Chambers." In The Rome Statute for the International Criminal Court, 91–227. Brill | Nijhoff, 2010. http://dx.doi.org/10.1163/ej.9789004186132.i-344.30.
Full text
2
Young, John W., and John Kent. "13. ‘Stagflation’ and the Trials of Détente, 1973–6." In International Relations Since 1945. Oxford University Press, 2013. http://dx.doi.org/10.1093/hepl/9780199693061.003.0017.
Full textAbstract:
This chapter examines the onset of the so-called stagflation and the problems that beset détente during the period 1973–1976. In the aftermath of Israel’s victories in the Six Day War, a situation of ‘no peace, no war’ prevailed in the Middle East. Attempts in 1970 and 1971 by the United Nations and the United States to make progress on a peace settlement proved futile. The chapter first considers the Middle East war of October 1973, which sparked a confrontation between the US and the Soviet Union, before discussing the impact of stagflation, especially on the Bretton Woods system. It then explores political problems in Europe and how European détente reached a high point in the Helsinki conference of 1975. It concludes with an analysis of détente and crises in less developed countries such as Chile, South Vietnam, Cambodia, and Angola.
3
Young, John W., and John Kent. "13. ‘Stagflation’ and the Trials of Détente, 1973–6." In International Relations Since 1945, 321–43. Oxford University Press, 2020. http://dx.doi.org/10.1093/hepl/9780198807612.003.0013.
Full textAbstract:
This chapter examines the onset of the so-called stagflation and the problems that beset détente during the period 1973–6. In the aftermath of Israel’s victories in the Six Day War, a situation of ‘no peace, no war’ prevailed in the Middle East. Attempts in 1970 and 1971 by the United Nations and the United States to make progress on a peace settlement proved futile. The chapter first considers the Middle East War of October 1973, which sparked a confrontation between the US and the Soviet Union, before discussing the impact of stagflation, especially on the Bretton Woods system. It then explores political problems in Europe and how European détente reached a high point in the Helsinki conference of 1975. It concludes with an analysis of détente and crises in less developed countries such as Chile, South Vietnam, Cambodia, and Angola.
4
Penman, Alan D., Kimberly W. Crowder, and William M. Watkins. "Corticosteroids in the Treatment of Acute Optic Neuritis." In 50 Studies Every Ophthalmologist Should Know, 285–90. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780190050726.003.0047.
Full textAbstract:
The Optic Neuritis Treatment Trial (ONTT) was a randomized, placebo-controlled, clinical trial in patients with a history consistent with acute unilateral optic neuritis to determine whether treatment with either oral prednisone or intravenous methylprednisolone speeded the recovery of vision and improve visual outcome. The study found that intravenous methylprednisolone (started within eight days of symptom onset) followed by oral prednisone speeded the recovery of visual loss due to optic neuritis and resulted in slightly better vision at six months. Oral prednisone alone, however, was an ineffective treatment and may increase the risk of new episodes of optic neuritis.
5
Katz, Jeffery, and Steve Greenberg. "Efficacy and Safety of a Paired Sedation and Ventilator Weaning Protocol for Mechanically Ventilated Patients in Intensive Care." In 50 Studies Every Intensivist Should Know, edited by Edward A. Bittner and Michael E. Hochman, 27–32. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190467654.003.0005.
Full textAbstract:
The chapter entitled examines the efficacy of pairing daily sedation awakening trials (SAT) with daily spontaneous breathing trials (SBT) in intensive care unit (ICU) patients on a mechanical ventilator. Three-hundred thirty-six ICU patients requiring mechanical ventilation for > 12 hours and eligible for a ventilator weaning trial were included. The authors compared the number of ventilator-free days in patients who received an SBT alone versus an SAT + SBT. Patients in the intervention group (SAT + SBT) spent a mean of 3.1 more days liberated from the ventilator when compared to the control group. Medical ICU patients undergoing paired SAT + SBT may experience improved outcomes versus those with SBT alone.
6
Mendy, Marcel. "Arresting Habré." In The President on Trial, 77–80. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198858621.003.0011.
Full textAbstract:
This chapter addresses the role of Marcel Mendy, head of Communications for the Extraordinary African Chambers (EAC), and his office during Hissène Habré's arrest, the most politically sensitive moment of the process. At the EAC, Mendy's unit reported on the activities of the EAC, represented the EAC as spokesperson, and organized media events for the prosecutor. A central task of the unit was to organize media coverage of the Habré trial by the national and international press through accreditation and streaming the trial on the EAC's website. Mendy's unit was also in charge of keeping Habré's arrest confidential until the operation occurred. On the basis of information obtained from investigation reports established in both Brussels and N'Djamena about detention centres and suspected locations of mass graves, Prosecutor M'Backé Fall decided to proceed with the arrest of Hissène Habré a few days after his return from a mission in Chad. Information had to be locked down to keep the opposing camp from being alerted. Indeed, the public only learned of the arrest the following day.
7
Montgomery, Heather. "Child Sex Tourism." In Tourism and Crime. Goodfellow Publishers, 2010. http://dx.doi.org/10.23912/978-1-906884-14-7-1286.
Full textAbstract:
If sex tourism is the dark, if debated, side of tourism, then child sex tourism represents the line in the sand that should never be crossed. While sex tourism involving adults provokes a variety of opinions and positions (Cohen, 1982; Oppermann, 1998; Kempadoo et al., 2005; O’Connell-Davidson and Sánchez Taylor, 2005; Sánchez Taylor, 2006; Day, 2007; Eades, 2009), child prostitution involving tourists is universally condemened and high-profile cases, such as the trial of Gary Glitter, point to the depths of public revulsion against such behaviour. The last 20 years have seen vocal campaigns against child sex tourism, resulting in changes in national legislation in many countries, statements and taskforces from the World Tourism Organization, the inauguration of World Congresses against the Commercial Sexual Exploitation of Children and a universal determination to stamp out a crime and a moral outrage. Despite the public outcry and changes in legislation, however, child sex tourism continues and, in some ways, the moral indignation that the subject arouses obscures certain aspects of the situations in which children caught up in prostitution live and work. There is still a dearth of information about how children meet clients, what is expected of them and their paths in and out of prostitution (Montgomery, 2001a, 2001b). Their clients are even more unknown and there is very little research (as opposed to anecdotal) evidence that discusses their motivations, their modus operandi or their choices about which countries they will visit and where they can find opportunities for sexual activity with children (Ennew, 1986; Montgomery, 2008; for an excellent overview of the available evidence see O’Connell-Davidson, 2005). At both national and international levels, legislation to protect children, although much heralded, has proved inadequate, and left unanswered important questions about enforcement and practical help for the children affected. In this chapter, I examine the legislation in place to tackle the problem of child sex tourism, and contrast this with a case study from Thailand of a small community in which children worked as prostitutes in order to support their parents and themselves. In doing so, I am not arguing for any moral ambivalence or ambiguity in discussions of child sex tourism. Rather, I wish to point out the lacuna between those discussions and the lived realities of the children.
8
Reen, J. J., and Michael Lang. "An Investigation into the Success Factors of Small Software Companies." In International Business Strategy and Entrepreneurship, 95–103. IGI Global, 2014. http://dx.doi.org/10.4018/978-1-4666-4753-4.ch006.
Full textAbstract:
This chapter is concerned with the study of success factors in small software firms. The decision to focus specifically on the software sector, as opposed to high technology firms or the generic small firm, is because the authors believe that there are elements in the operation of a software business that are unique to that domain and do not have equivalents in other industries. Interviews were carried out with six owner/managers of small to medium software firms. The interview data was interpreted using a qualitative analysis approach based on the principles of grounded theory. A number of factors emerged from this analysis, a few of which have parallels in the generic small firm literature (e.g. market positioning, export orientation, distribution channel), as well as a few others which appear to be specific to the software industry (e.g. remote accessibility, ability to demonstrate/trial at global reach with minimal expense, software reuse, etc.).
9
"Conservation, Ecology, and Management of Catfish: The Second International Symposium." In Conservation, Ecology, and Management of Catfish: The Second International Symposium, edited by RUSSELL M. BARABE and DONALD C. JACKSON. American Fisheries Society, 2011. http://dx.doi.org/10.47886/9781934874257.ch54.
Full textAbstract:
<em>Abstract</em>.—Use of trotlines to collect data on catfish populations can lead to incidental capture of endangered turtles. We evaluated the effectiveness of Zote© soap as a way to prevent capture of turtles on trotlines fished in coastal rivers of Mississippi and compared capture efficiency of cut bait and Zote© soap in research ponds. More than 11,000 hooks baited with Zote© soap were fished overnight in six coastal rivers of Mississippi, resulting in the capture of zero turtles, 193 blue catfish <em>Ictalurus furcatus</em>, and 462 channel catfish <em>I. punctatus</em>. Direct comparisons with other baits were not conducted in the coastal rivers because capture of a single endangered turtle would have resulted in revocation of our sampling permit. Therefore, comparisons of cut bait and Zote© soap were conducted in research ponds. The fi rst trial fished 440 hooks each of cut bait and Zote© soap. Cut bait and Zote© soap collected one and zero turtles, respectively, while each bait captured 48 channel catfi sh. The second trial fished 120 hooks each of cut bait and Zote© soap. Cut bait and Zote© soap collected two and zero turtles, respectively, and 15 and 8 channel catfish, respectively. A Mann–Whitney U-test indicated no signifi cant difference between bait type in number of catfish or turtles captured in either trial. While statistical differences in turtle catch between bait types were not found, preventing any capture of endangered turtles in the field is a high priority and our results indicated that use of Zote© soap provides the best method for eliminating turtle capture on trotlines in coastal rivers of Mississippi.
10
Temkin, Sefton D. "Heading West." In Creating American Reform Judaism, 95–103. Liverpool University Press, 1998. http://dx.doi.org/10.3828/liverpool/9781874774457.003.0015.
Full textAbstract:
This chapter details Isaac Mayer Wise’s appointment to Cincinnati. The generally accepted version of Wise’s appointment is that in August 1853, Jacob Goodheart, then treasurer of the Congregation B’nai Jeshurun, wrote to Wise out of the blue asking whether he would accept the position of rabbi; that Wise stipulated election for life, no trial sermon, and not taking up his duties before a lapse of six months, and a salary that would make him independent of gifts; and that five days after communicating the requirements he ‘received a telegram to the effect that he had been unanimously elected rabbi of the congregation on his own terms’. This story can be traced back to Wise’s Reminiscences, where he says he received Goodheart’s letter while he was in a mood of defeat and self-pity following the failure of his history book from the previous chapter. But by the time this book appeared, Wise had received the Cincinnati appointment. And he was already in communication with B’nai Jeshurun before receiving the letter.
Conference papers on the topic "International Six Days Trial"
1
Turple, A. G. G., M. N. Levin, J. Hirish, C. J. Carter, R. M. Jay, P. J. Powers, M. Andrew, H. N. Magnani, R. D. Hull, and M. Gent. "A DOUBLE BLIND RANDOMIZED TRIAL OF ORG 10172 LOW MOLECULAR WEIGHT HEPARINOID IN THE PREVENTION OF DEEP VEIN THROMBOSIS IN PATIENTS WITH THROMBOTIC STROKE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643239.
Full textAbstract:
The optimal method of venous thrombosis prophylaxis in patients with stroke is uncertain. ORG 10172 is a low molecular weight heparinoid consisting principally of heparan and dermatan sulphates. In animal studies, ORG 10172 is as effective as unfractionated heparin in preventing venous thrombosis but produces less bleeding. There have been a limited number of descriptive studies on its use in humans, but to date randomized efficacy trials of ORG 10172 in the prevention of venous thrombosis have not been reported. A double blind randomized trial was carried out to compare ORG 10172 with placebo in the prevention of deep vein thrombosis in patients with thrombotic stroke. Seventy-five patients were randomized to receive ORG 10172 (50 patients) in a loading dose of 1,000 anti-Xa units intravenously followed by 750 anti-Xa units subcutaneously 12 hourly or placebo (25 patients). Prophylaxis was commenced within 7 days of stroke onset, continued for 14 days or until discharge from hospital, if earlier. Venous thrombosis surveillance was carried out with 125-1 fibrinogen leg scanning and impedance plethysmography. Venous thrombosis was confirmed by venography which occurred in 2 of 50 (4%) in the ORG 10172 group and 7 of 25 (28%) in the placebo group (p=0.005). The corresponding rates for proximal vein thrombosis were 0% and 16%, respectively (p=0.01). There was one major haemorrhage in the treated group and one minor haemorrhage in the placebo group. The anti-factor Xa levels (units/ml; mean ± SE) gradually rose from 0.18 ± 0.001 and 0.06 ± 0.01 six and 12 hours after injection on the first day to 0.24 ± 0.02 and 0.12 ± 0.01 after 11 days treatment. The results of this study indicate that ORG 10172 heparinoid is effective prophylaxis against deep vein thrombosis in patients with acute thrombotic stroke.
2
Kurts, Phillip P., Hayden Marcollo, Andrew A. Kilner, Daniel Johnstone, Andrew E. Potts, Peter Pezet, and Tricia Hill. "Field Trial of Vortex-Induced Vibration Suppression Technology for Drilling Riser Buoyancy." In ASME 2019 38th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/omae2019-96426.
Full textAbstract:
Abstract Instrumented field trials of Longitudinally Grooved Suppression (LGS) VIV suppression buoyancy modules have been completed on deep water drilling risers in the Gulf of Mexico. The field trials were used to validate the performance of the technology, which had previously been evaluated using prototype scale model tests. The measured riser responses over two drilling campaigns spanning more than six months were compared with each other and the outputs of computational riser modeling to validate the hydrodynamic parameter set derived through scale model tests and provide validated assessments of the suppression technology performance. The measured response of drilling risers equipped with LGS buoyancy has been compared with a publicly available dataset for the VIV response of a conventionally buoyed riser, showing reduced VIV response in agreement with model test results. Measured flex joint angles, current profiles and riser accelerations were used to validate the hydrodynamic parameters used in numerical riser analysis. Using the validated hydrodynamic parameters, the VIV and drag suppression performance was demonstrated by comparison with the model predictions for risers equipped with conventional buoyancy modules. Eddy current occurrence statistics for a location in the Gulf of Mexico were used to calculate the expected annual operability performance for both configurations. For the base case parameters, 12 days of annual operability improvement was predicted when using LGS buoyancy modules. A sensitivity study determined the effect of varying analysis assumptions on the predicted operability improvements. Measured current data from 2014 was also used to determine the operability benefits which could be realized within a year in which severe eddy current activity occurred. The analysis performed serves to validate the previous laboratory tests as well as answer questions about the applicability of high Reynolds Number test results to VIV suppression devices in the field. The use of previously validated testing and analysis methods is shown to provide reliable estimates of suppression technology performance which are borne out by testing in the field. This paper presents the first published field trial of shaped buoyancy type VIV suppression, a group of technologies which have until now only been demonstrated using scale model tests and Computational Fluid Dynamics simulations.
3
Milazzotto, F., M. Carelli, C. Citone, G. Di Macro Tullio, G. C. Gambelli, P. Giampaolo, U. Malinconico, C. Polizzi, and U. Cornelli. "EFFECTIVENESS OF DEFIBROTIDE IN THE TREATMENT OF ACUTE MYOCARDIAL INFARCTION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643146.
Full textAbstract:
Defibrotide (D) is an extractive polydesoxyribonucleotide. In preclinical studies the product was shown to be active as a pro -fibrinolytic, antithrombotic and thrombolytic agent while comply tely devoid of anticoagulant activity. In animal models, D was found to afford striking protection from the effects of acute lethal and non lethal myocardial ischemia as well as from myo -cardial injury following reperfusion. In this open single - blim trial, D was administered to patients with acute myocardial infaj ction (AMI) for the prevention of complicating arrhythmias; throy bus formation, pericarditis, etc.Sixty patients with AMI were divided randomly into two groups of 30 patients each. One group was treated with D by 6-hour drip infusion for 3 consecutive days (2.8 g on the first day, then 2.4 g daily). The other group was treated with equal volumes of physiological salt solution. All patients received conventional trea_t ment for AMI. The two trial groups were sufficiently homogeneous in terms of AMI type, age and sex distribution, PCT, Forrester index, Holter, and Peel index. D treatment proved effective in reducing the incidence of severe arrhythmia (p < 0.05), thrombus formation (p < 0.05), and pericarditis (p < 0.01). CPK, TT and PTT readings were not modified by the treatment; the incidence of post-AMI angina and the number of deaths (4 in each group) were similar in the two groups. The results of this pilot study are encouraging; further clinical trials are currently in progress to assess D activity in larger groups of patients treated with the product at higher dosages.
4
Collins, R. "RANDOMIZED FACTORIAL TRIAL OF HIGH-DOSE INTRAVENOUS STREPTOKINASE, OF ORAL ASPIRIN, AND OF INTRAVENOUS HEPARIN IN ACUTE MYOCARDIAL INFARCTION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643623.
Full textAbstract:
619 patients with suspected acute myocardial infarction (MI) were randomized to receive either a high-dose short-term intravenous infusion of streptokinase (1.5 MU over one hour) or placebo. In addition, using a “2x2x2 factorial” design, patients were also randomized to receive either oral aspirin (325 mg on alternate days for 28 days) or placebo, and separately randomized to receive either intravenous heparin (1,000 IU/hour for 48 hours) or no heparin. Streptokinase (SK) was associated with a non-significant decrease in hospital mortality (7.7% allocated SI< vs 9.2% allocated placebo) and increase in non-fatal reinfarction (3.6% vs 2.9%). There were significantly more minor adverse events after SK (e.g. hypotension, allergies, bruises or minor bleeds), but no excess of strokes or of anaphylactic shock.Aspirin was associated with fewer reinfarctions (2.9% allocated aspirin vs 3.9% allocated placebo; NS), deaths (6.1% vs 10.5%; 2P<0.04) and strokes (0.3% vs 2.0%; 2P<0.1).Heparin was associated with a decrease in reinfarction (1.9% allocated heparin vs 4.9% allocated no heparin; 2P<0.04), though not in mortality (8.3% vs 8.2%; NS), and with a trend towards more strokes (1.6% vs 0.7%; NS) and more bruising and bleeding (14% vs 11%; NS). To assess reliably the effects of SK and aspirin on major endpoints, several hundred hospitals are now collaborating in a large (about 20,000 patients planned) randomized trial (ISIS-2).
5
Mauri, F. "EFFECTIVENESS OF INTRAVENOUS THROMBOLYTIC TREATMENT IN ACUTE MYOCARDIAL INFARCTION:SHORT AND MEDIUM TERM PROGNOSIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643624.
Full textAbstract:
An unblinded trial of intravenous stretokinase in early acute myocardial infarction was planned to study wheter the drug produces a clinically relevant benefit in terms of reduction of in-hospital and one year mortality.11806 pts in one hundred and seventy six coronary care units were enrolled over 17 months.Patients admitted within 12 h after o.nSet of symptons and with no contraindications to SK were randomized to receive SK in addition to usual treatment and complete data were obtained in 11712 for what concerns in hospital prognosis.At 21 days overall hospital mortality was 10.7% in SK recipients versus 13%,in controls,an 18% reduction(p=0.0002,relative risk 0.81).The extent of beneficial effect appears to be a function of time from onset of pain to SK infusion(relative risk 0.74,0.80, 0.87 and 1.19 for the 0-3,3-6,6-9 and 9-12 h subgroups).The data of 1-year follow-up concerning 11605 pts(95.3% of the whole population)were available up to December the 31st.1987.4333 pts out of the SK-treated group(74.0%)and 4219 out of the control one (72.1%)were alive,with a significant difference.These results document that the benefit produced by SK in the hospital period remains substantially unchanged.The differences in mortality in favour of SK vs.C remain highly significant specifically for the 0-3 and 3-6 hrs subgroups and is dramatic for patients treated between one hour from onset of symptoms. 503 out of the 637 treated with SK were alive at 1-year follow-up versus 443 out of 641 control group pts:the amplitude of the benefit seems to be further increased in this particular subgroup.The GISSI results document conclusively that an acute thrombolytic treatment with SK in AMI is effective in reducing mortality not only over the short,but also over the medium period.
6
Istighosah, Nining, and Aprilia Nurtika Sari. "Oxytocyn Massage Using Innovative Massage Tool and Conventional Effleurage Techniques to Increase Breastmilk Production in Post Partum Mothers." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.03.48.
Full textAbstract:
ABSTRACT Background: Exclusive breastfeeding for the first six months of life is recommended by the World Health Organization and United Nations Children’s Fund. The World Health Organization (WHO) recommends exclusive breastfeeding for up to 6 months and continuous breastfeeding for up to 2 months. Exclusive breastfeeding is the most effective intervention to reduce infant mortality. It is estimated that it can prevent 13% of under-five mortality in low-income countries. This study aimed to analyze the difference in breastmilk volume before and after the mother received the oxytocin massage using innovative massage tool and conventional effleurage techniques. Subjects and Methods: This was a quasi-experiment study with a non-randomized control trial pretest-posttest design was conducted in Kediri from August to September 2020. The sample used was post-partum women on days 4 to 10 using purposive sampling technique. The dependent variable was amount of breast milk production. The independent variables were oxytocin massage treatment with effleurage technique, and the combination of oxytocin massage, effleurage technique and innovation massage tool. The data was analyzed by T-Test. Results: In the oxytocin massage treatment group used the conventional Effleurage method (Mean = 42; SD = 29) while in the massage treatment group using an innovative massage tool (Mean = 60; SD = 51) this was very different in the control group (Mean = 3.4; SD = 8.8) and it was statistically significant (p= 0.005). Conclusion: Giving oxytocin massage using an innovative massage device were higher than oxytocin massage using the conventional Effleurage method and massage using this innovative massage device had a statistical impact on increasing breast milk production Keywords: oxytocin massage, breast milk production, innovative massage tool Correspondence: Nining Istighosah. School of Midwifery Dharma Husada Kediri. Jl. Penanggungan No. 41-A Kediri. E-mail: dealovanining@gmail.com. Mobile: +6281231352032. DOI: https://doi.org/10.26911/the7thicph.03.48
7
Turro, R., JCE Perez, M. Ble, M. Rosinach, J. Michelena, A. Mata, GL Nava, and BA Dayeh. "GASTRIC ENDOSCOPIC SLEEVE PLICATION (GESP): AN INTERNATIONAL MULTICENTER PROSPECTIVE TRIAL." In ESGE Days. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1704163.
Full text
8
"A RANDOMIZED, DOUBLE BLIND STUDY OF A LOW MOLECULAR WEIGHT HEPARIN (KABI 2165) ONCE DAILY AND LOW DOSE STANDARD HEPARIN TWICE DAILY, IN THE PREVENTION OF POST OPERATIVE DEEP VEIN THROMBOSIS IN GENERAL SURGERY. A French Multicenter Trial." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643594.
Full textAbstract:
The efficacy and safety of a low molecular weight heparin (Kabi 2165) in preventing postoperative deep vein thrombosis (D.V.T.), was assessed in a double blind randomly allocated multicenter trial. 385 patients were included and analysed on a intention to treat basis. Kabi 2165 was given S.C. 24 hourly in 2 500 anti-factor Xa units and compared with standard low dose calcium heparin 5 000 i.u. S.C. 12 hourly in patients undergoing major abdominal or gynaecological surgery. The first dose was administered two hours before operation in both groups. The relevant characteristics of the patients in the two treatment groups were similar. The two groups were well matched for risk factors which could predispose to D.V.T.DVT was detected by the radioactive fibrinogen test. Venography was performed whenever a positive scan developed in a patient. Six (3,1 96) of 195 patients receiving Kabi 2165 and seven (3,7 96) of 190 patients in the standard heparin group developed D.V.T. No pulmonary embolism we re detected during the prophylactic regimens. There was no significant difference between the two groups in terms of blood loss during surgery, postoperative drainage, blood transfusion, wound haematoma. Mean hemoglobin levels and mean hematocrit values preoperatively and postoperatively (day 1 and 6) were :There were no statistically significant differences in both groups. No thrombocytopenia was reported in this study. The antifactor Xa activity was significantly higher in the Kabi 2165 group.In conclusion, Kabi 2165 once daily is as effective and safe as standard heparin twice daily in preventing postoperative D.V.T. in general surgery.
9
Carriero, M. R., G. Pintucci, M. N. Castagnoli, R. Colombo, B. Lombardi, L. Mussoni, and G. de Gaetano. "ASPIRIN DOES NOT INHIBIT FIBRINOLYTIC ACTIVITY IN TIA PATIENTS AFTER VENOUS OCCLUSION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644429.
Full textAbstract:
We have recently shown that In normal subjects aspirin (1,300 mg) and Indobufen (400 mg), a new cyclo-oxygenase Inhibitor structurally unrelated to salycilate, lower the fibrinolytic activity, without modifying t-PA antigen levels, after venous occlusion (VO). The aim of this study was to investigate whether aspirin reduces fibrinolytic response to VO also In patients with TIA. These patients were selected In view of controlled clinical trials showing reduction of TIA recurrency and stroke by treatment with high dose aspirin. Six males (56-65 yrs old), with previous TIA (< 1 year) were selected; the presence of diffuse atherothrombotlc lesions was demonstrated by doppler sonography and angiography. All patients were given, ten days apart, aspirin (600 mg daily x 2) or Indobufen (200 mg daily x 2) following a randomized cross-over single blind scheme. In all patients 10 minutes VO applied before any drug administration, Induced activation of the fibrinolytic system as assessed by euglobulin lysis area on fibrin plates (from 226±47 to 643±57 mm2), t-PA antigen (from 13.8± 1.0 to 40.9±3.1 ng/ml) and PA-1 activity (from 39.5+5.0 to 14.8±1.6 AU/ml). Neither aspirin nor Indobufen Ingestion resulted In any Inhibitory effect on fibrinolytic response to VO while both drugs suppressed serum thromboxane 02 generation by more than 98%. In conclusion high dose aspirin and Indobufen do not Impair the fibrinolytic potential In TIA patients with atherothrombotlc lesions. The reasons for the different behaviour of patients In respect to young healthy volunteers remain to be established.
10
Gerhart, T., H. Yett, A. Donovan, M. A. Lee, M. Smith, and E. W. Salzman. "ORGANON 10172 VS. WARFARINTO PREVENT VENOUS THROMBOSIS AFTER HIP FRACTURE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643686.
Full textAbstract:
Deep venous thrombosis (DVT) remains a serious and frequent complication after fracture of the hip, and even the mostefficacious prophylactic agents, e.g., warfarin, may fail to prevent DVT in up to 2056 of cases. There is evidence that low molecular weight heparin or heparin-like agents may have advantages in antithrombotic prophylaxis with reduced hemorrhagic sideeffects in patients at risk of DVT. We are engaged in a randomized prospective trial comparing the antithrombotic effect ofwarfarin (PT 1.5x control)with that of Organon 10172, a mixture ofsulfated low molecular weight glycosamioglycans (750 anti-Xa u b.i.d. sc., begunpreop and continued 9 days, followe by warfarin). Diagnosis is by 125-1 fibrinogen scan and impedence plethysmography with confirmatory phlebography. At present71 patients have been admitted, and patient groups are comparable in age, sex, type of fracture, and all other significant respects. DVT has been diagnosed in 7of 36 patients given warfarin an in 1 of35 patients who received Organon10172. Pulmonary embolism has not beenencountered. GI bleeding has occurred twice on warfarin and once on Organon 10172 There has been no difference in estimated operative blood loss, transfusion requirements, or other major bleeding complications.One patient on warfarin died ofmyocardial infarction and pneumonia. There were no other adverse reactions.The study is still in progress. The present trend in the results suggests that the heparinoid Organon 10172 may be a promising new agent to prevent DVT in high risk patients, such as those with fractures of the hip.
Reports on the topic "International Six Days Trial"
1
Fulco, Charles S., Stephen R. Muza, Beth Beidleman, Juli Jones, Eric Lammi, Janet Staab, Paul B. Rock, et al. Living for Six Days at 2200 M Improves Time-Trial Performance of Sea-Level Residents Exposed to 4300 M. Fort Belvoir, VA: Defense Technical Information Center, February 2008. http://dx.doi.org/10.21236/ada479302.
Full text
2
Patton, Amy, Kylie Dunavan, Kyla Key, Steffani Takahashi, Kathryn Tenner, and Megan Wilson. Reducing Stress, Anxiety, and Depression for NICU Parents. University of Tennessee Health Science Center, May 2021. http://dx.doi.org/10.21007/chp.mot2.2021.0012.
Full textAbstract:
This project aims to appraise evidence of the effectiveness of various practices on reducing stress, anxiety, and depression among parents of infants in the neonatal intensive care unit (NICU). The project contains six research articles from both national and international journals. Study designs include one meta-analysis, one randomized controlled trial, one small scale randomized controlled trial, one prospective phase lag cohort study, on pretest-posttest study, and one mixed-methods pretest-posttest study. Recommendations for effective interventions were based on best evidence discovered through quality appraisal and study outcomes. All interventions, except for educational programs and Kangaroo Care, resulted in a statistically significant reduction of either stress, anxiety, and/ or depression. Family centered care and mindfulness-based intervention reduced all barriers of interest. There is strong and high-quality evidence for the effect of Cognitive Behavioral Therapy on depression, moderate evidence for the effect of activity-based group therapy on anxiety, and promising evidence for the effect of HUG Your Baby on stress.