Academic literature on the topic 'Interneurones à somatostatine'

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Journal articles on the topic "Interneurones à somatostatine"

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Yekhlef, Latefa, Gian Luca Breschi, Laura Lagostena, Giovanni Russo, and Stefano Taverna. "Selective activation of parvalbumin- or somatostatin-expressing interneurons triggers epileptic seizurelike activity in mouse medial entorhinal cortex." Journal of Neurophysiology 113, no. 5 (2015): 1616–30. http://dx.doi.org/10.1152/jn.00841.2014.

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GABAergic interneurons are thought to play a critical role in eliciting interictal spikes (IICs) and triggering ictal discharges in temporal lobe epilepsy, yet the contribution of different interneuronal subtypes to seizure initiation is still largely unknown. Here we took advantage of optogenetic techniques combined with patch-clamp and field recordings to selectively stimulate parvalbumin (PV)- or somatostatin (SOM)-positive interneurons expressing channelrhodopsin-2 (CHR-2) in layers II–III of adult mouse medial entorhinal cortical slices during extracellular perfusion with the proconvulsiv
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Riedemann, Therese. "Diversity and Function of Somatostatin-Expressing Interneurons in the Cerebral Cortex." International Journal of Molecular Sciences 20, no. 12 (2019): 2952. http://dx.doi.org/10.3390/ijms20122952.

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Inhibitory interneurons make up around 10–20% of the total neuron population in the cerebral cortex. A hallmark of inhibitory interneurons is their remarkable diversity in terms of morphology, synaptic connectivity, electrophysiological and neurochemical properties. It is generally understood that there are three distinct and non-overlapping interneuron classes in the mouse neocortex, namely, parvalbumin-expressing, 5-HT3A receptor-expressing and somatostatin-expressing interneuron classes. Each class is, in turn, composed of a multitude of subclasses, resulting in a growing number of interneu
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Lukomska, Agnieszka, Grzegorz Dobrzanski, Monika Liguz-Lecznar, and Malgorzata Kossut. "Somatostatin receptors (SSTR1-5) on inhibitory interneurons in the barrel cortex." Brain Structure and Function 225, no. 1 (2019): 387–401. http://dx.doi.org/10.1007/s00429-019-02011-7.

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AbstractInhibitory interneurons in the cerebral cortex contain specific proteins or peptides characteristic for a certain interneuron subtype. In mice, three biochemical markers constitute non-overlapping interneuron populations, which account for 80–90% of all inhibitory cells. These interneurons express parvalbumin (PV), somatostatin (SST), or vasoactive intestinal peptide (VIP). SST is not only a marker of a specific interneuron subtype, but also an important neuropeptide that participates in numerous biochemical and signalling pathways in the brain via somatostatin receptors (SSTR1-5). In
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Friend, Lindsey, Ryan Williamson, Collin Merrill, et al. "Hippocampal Stratum Oriens Somatostatin-Positive Cells Undergo CB1-Dependent Long-Term Potentiation and Express Endocannabinoid Biosynthetic Enzymes." Molecules 24, no. 7 (2019): 1306. http://dx.doi.org/10.3390/molecules24071306.

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The hippocampus is thought to encode information by altering synaptic strength via synaptic plasticity. Some forms of synaptic plasticity are induced by lipid-based endocannabinoid signaling molecules that act on cannabinoid receptors (CB1). Endocannabinoids modulate synaptic plasticity of hippocampal pyramidal cells and stratum radiatum interneurons; however, the role of endocannabinoids in mediating synaptic plasticity of stratum oriens interneurons is unclear. These feedback inhibitory interneurons exhibit presynaptic long-term potentiation (LTP), but the exact mechanism is not entirely und
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Henriques, Vanessa Jorge, Angela Chiavegato, Giorgio Carmignoto, and Marta Gómez-Gonzalo. "Astrocytes Modulate Somatostatin Interneuron Signaling in the Visual Cortex." Cells 11, no. 9 (2022): 1400. http://dx.doi.org/10.3390/cells11091400.

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At glutamatergic synapses, astrocytes respond to the neurotransmitter glutamate with intracellular Ca2+ elevations and the release of gliotransmitters that modulate synaptic transmission. While the functional interactions between neurons and astrocytes have been intensively studied at glutamatergic synapses, the role of astrocytes at GABAergic synapses has been less investigated. In the present study, we combine optogenetics with 2-photon Ca2+ imaging experiments and patch-clamp recording techniques to investigate the signaling between Somatostatin (SST)-releasing GABAergic interneurons and as
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Halabisky, Brian, Fran Shen, John R. Huguenard, and David A. Prince. "Electrophysiological Classification of Somatostatin-Positive Interneurons in Mouse Sensorimotor Cortex." Journal of Neurophysiology 96, no. 2 (2006): 834–45. http://dx.doi.org/10.1152/jn.01079.2005.

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Classification of inhibitory interneurons is critical in determining their role in normal information processing and pathophysiological conditions such as epilepsy. Classification schemes have relied on morphological, physiological, biochemical, and molecular criteria; and clear correlations have been demonstrated between firing patterns and cellular markers such as neuropeptides and calcium-binding proteins. This molecular diversity has allowed generation of transgenic mouse strains in which GFP expression is linked to the expression of one of these markers and presumably a single subtype of
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Jang, Hyun Jae, Hyowon Chung, James M. Rowland, Blake A. Richards, Michael M. Kohl, and Jeehyun Kwag. "Distinct roles of parvalbumin and somatostatin interneurons in gating the synchronization of spike times in the neocortex." Science Advances 6, no. 17 (2020): eaay5333. http://dx.doi.org/10.1126/sciadv.aay5333.

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Synchronization of precise spike times across multiple neurons carries information about sensory stimuli. Inhibitory interneurons are suggested to promote this synchronization, but it is unclear whether distinct interneuron subtypes provide different contributions. To test this, we examined single-unit recordings from barrel cortex in vivo and used optogenetics to determine the contribution of parvalbumin (PV)– and somatostatin (SST)–positive interneurons to the synchronization of spike times across cortical layers. We found that PV interneurons preferentially promote the synchronization of sp
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Vaes, Josine E. G., Chantal M. Kosmeijer, Marthe Kaal, et al. "Regenerative Therapies to Restore Interneuron Disturbances in Experimental Models of Encephalopathy of Prematurity." International Journal of Molecular Sciences 22, no. 1 (2020): 211. http://dx.doi.org/10.3390/ijms22010211.

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Encephalopathy of Prematurity (EoP) is a major cause of morbidity in (extreme) preterm neonates. Though the majority of EoP research has focused on failure of oligodendrocyte maturation as an underlying pathophysiological mechanism, recent pioneer work has identified developmental disturbances in inhibitory interneurons to contribute to EoP. Here we investigated interneuron abnormalities in two experimental models of EoP and explored the potential of two promising treatment strategies, namely intranasal mesenchymal stem cells (MSCs) or insulin-like growth factor I (IGF1), to restore interneuro
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De Gregorio, Roberto, Xiaoning Chen, Emilie I. Petit, Kostantin Dobrenis, and Ji Ying Sze. "Disruption of Transient SERT Expression in Thalamic Glutamatergic Neurons Alters Trajectory of Postnatal Interneuron Development in the Mouse Cortex." Cerebral Cortex 30, no. 3 (2019): 1623–36. http://dx.doi.org/10.1093/cercor/bhz191.

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Abstract In mice, terminal differentiation of subpopulations of interneurons occurs in late postnatal stages, paralleling the emergence of the adult cortical architecture. Here, we investigated the effects of altered initial cortical architecture on later interneuron development. We identified that a class of somatostatin (SOM)-expressing GABAergic interneurons undergoes terminal differentiation between 2nd and 3rd postnatal week in the mouse somatosensory barrel cortex and upregulates Reelin expression during neurite outgrowth. Our previous work demonstrated that transient expression (E15-P10
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Shen, Wei, Ru Ba, Yan Su, et al. "Foxg1 Regulates the Postnatal Development of Cortical Interneurons." Cerebral Cortex 29, no. 4 (2018): 1547–60. http://dx.doi.org/10.1093/cercor/bhy051.

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AbstractAbnormalities in cortical interneurons are closely associated with neurological diseases. Most patients with Foxg1 syndrome experience seizures, suggesting a possible role of Foxg1 in the cortical interneuron development. Here, by conditional deletion of Foxg1, which was achieved by crossing Foxg1fl/fl with the Gad2-CreER line, we found the postnatal distributions of somatostatin-, calretinin-, and neuropeptide Y-positive interneurons in the cortex were impaired. Further investigations revealed an enhanced dendritic complexity and decreased migration capacity of Foxg1-deficient interne
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Dissertations / Theses on the topic "Interneurones à somatostatine"

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Mohamed, Boubacar. "Contrôle bidirectionnel du couplage neurovasculaire par les interneurones à somatostatine." Electronic Thesis or Diss., Sorbonne université, 2024. http://www.theses.fr/2024SORUS408.

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Le couplage neurovasculaire, qui relie l'activité neuronale au débit sanguin cérébral, est altéré précocement dans plusieurs troubles neurologiques et sous-tend l'imagerie cérébrale fonctionnelle. Ce processus complexe implique de multiples acteurs cellulaires, les interneurones inhibiteurs en particulier faisant l'objet d'une attention croissante, mais les mécanismes qui sous-tendent la façon dont ils contrôlent le flux sanguin cérébral restent insaisissables. Cette étude élucide les mécanismes par lesquels les interneurones à somatostatine contrôlent de manière bidirectionnelle le couplage n
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Gazan, Adeline. "Rôle des interneurones somatostatine dans la physiologie striatale :une approche morphologique, électrophysiologique et comportementale." Doctoral thesis, Universite Libre de Bruxelles, 2019. https://dipot.ulb.ac.be/dspace/bitstream/2013/283380/4/these.pdf.

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Le système des noyaux de la base possède un rôle essentiel dans de nombreuses fonctions telles que le contrôle et l’apprentissage moteur ainsi que les processus motivationnels et cognitifs. Le striatum constitue la principale structure d’entrée de ce système et peut être subdivisé en une région dorsale, impliquée dans cet apprentissage et ce contrôle moteur, et une partie ventrale, impliquée dans le système de la récompense et donc les processus motivationnels. Le striatum est composé de deux principales catégories de neurones :les neurones épineux de projection (ou « medium-sized spiny neuron
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Lepousez, Gabriel. "Physiologie de la somatostatine dans le bulbe olfactif de souris : des interneurones somatostatinergiques à la modulation du comportement olfactif." Paris 6, 2009. http://www.theses.fr/2009PA066490.

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Le neuropeptide somatostatine est largement exprimé dans le cerveau et son rôle modulateur via ses six récepteurs est bien établi dans les fonctions neuroendocriniennes et cognitives. La présence de la somatostatine et de ses récepteurs dans le système olfactif, et leur déclin dans plusieurs maladies neurodégénératives associées à des troubles précoces du sens de l’odorat, suggèrent que ce peptide participe au traitement de l’information olfactive. Notre travail démontre que, dans le bulbe olfactif de souris, la somatostatine est exprimée par des interneurones de van Gehuchten précisément situ
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Meyer, Thomas [Verfasser], and Marlene [Akademischer Betreuer] Bartos. "Diversity of somatostatin expressing interneurons in the dentate gyrus." Freiburg : Universität, 2018. http://d-nb.info/1166053636/34.

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Riedemann, Therese [Verfasser]. "Diversität und Funktion von Somatostatin-exprimierenden Interneuronen im cingulären Cortex der Maus / Therese Riedemann." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1213658764/34.

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Sohn, Jaerin. "Preprodynorphin-Expressing Neurons Constitute a Large Subgroup of Somatostatin-Expressing GABAergic Interneurons in the Mouse Neocortex." Kyoto University, 2016. http://hdl.handle.net/2433/215436.

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The version posted must include the following notice on the first page: This is the peer reviewed version of the following article: http://onlinelibrary.wiley.com/doi/10.1002/cne.23477/abstract, which has been published in final form at DOI: 10.1002/cne.23477. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第19610号<br>医博第4117号<br>新制||医||1015(附属図書館)<br>32646<br>京都大学大学院医学研究科医学専攻<br>(主査)教授 渡邉 大, 教授 髙橋 良輔, 教授 宮本 享<br>学位規則第4条第1項該当
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Kaas, Thomas [Verfasser], Knut [Gutachter] Holthoff, Christian [Gutachter] Hübner, and Stefan Jens [Gutachter] Hallermann. "Beteiligung von Somatostatin-positiven Interneuronen an Giant Depolarizing Potentials in der CA1-Region des neonatalen Hippokampus von Mäusen in vitro / Thomas Kaas ; Gutachter: Knut Holthoff, Christian Hübner, Stefan Jens Hallermann." Jena : Friedrich-Schiller-Universität Jena, 2021. http://d-nb.info/1239177402/34.

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Hays, Kimberly Lynne. "Neocortical Interneuron Subtypes Show an Altered Distribution in a Rat Model of Maldevelopment Associated With Epileptiform Activity." VCU Scholars Compass, 2007. http://scholarscompass.vcu.edu/etd_retro/31.

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Cortical malformations as a result of altered development are a common cause of human epilepsy. The cellular mechanisms that render neurons of malformed cortex epileptogenic remain unclear. Using a rat model of the malformation of microgyria, a previous study showed an alteration in the number of immunocytochemically-identified parvalbumin cells, a GABAergic inhibitory interneurons subtype (Rosen et al., 1998). A second study showed no change in the total number of GABAergic neurons (Schwarz et al., 2000). Consequently, we hypothesize that interneuron subtypes are differentially affected by ma
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Fischer, Tatjana [Verfasser], Jochen F. [Akademischer Betreuer] Staiger, Jochen F. [Gutachter] Staiger, Swen [Gutachter] Hülsmann, and Rainer [Gutachter] Mausberg. "Schichtenspezifische Charakterisierung Somatostatin-exprimierender Interneurone in der GIN- und SOMcre/tdTomato-Maus mittels neurochemischer Marker im primären somatosensorischen Barrel-Kortex / Tatjana Fischer ; Gutachter: Jochen F. Staiger, Swen Hülsmann, Rainer Mausberg ; Betreuer: Jochen F. Staiger." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2018. http://d-nb.info/1172500819/34.

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La, Fontaine Alexandre. "Rôle de la plasticité synaptique des interneurones somatostatinergiques dans l’apprentissage et la mémoire dépendants de l’hippocampe." Thèse, 2014. http://hdl.handle.net/1866/11874.

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La plasticité synaptique activité-dépendante forme la base physiologique de l’apprentissage et de la mémoire dépendants de l’hippocampe. Le rôle joué par les différents sous-types d’interneurones dans l’apprentissage et la mémoire hippocampiques reste inconnu, mais repose probablement sur des mécanismes de la plasticité spécifique aux synapses de certains sous-types d’interneurones. Les synapses excitatrices établies sur les interneurones de l’oriens-alveus dans l’aire CA1 exhibent une forme persistante de potentialisation à long terme induite par la stimulation chimique des récepteurs métabot
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Book chapters on the topic "Interneurones à somatostatine"

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Fasching, Liana, Melanie Brady, and Flora M. Vaccarino. "Cellular and Molecular Pathology in Tourette Syndrome." In Tourette Syndrome, 2nd ed., edited by Liana Fasching, Melanie Brady, and Flora M. Vaccarino. Oxford University Press, 2022. http://dx.doi.org/10.1093/med/9780197543214.003.0012.

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Abstract This chapter summarizes the available literature and data on pathological findings in Tourette syndrome. In severe, unremitting Tourette syndrome, there are decreases in somatostatin-positive/nitric oxide synthase–positive interneurons, fast spiking parvalbumin-positive/γ-aminobutyric acid-ergic interneurons, as well as tonically active cholinergic interneurons in the caudate nucleus and putamen. There is also a prominent increase in inflammation throughout the basal ganglia along with activation of microglial cells. Overall, neuroimaging studies suggest that the basal ganglia, a set
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Marty, Serge. "Differences in the regulation of neuropeptide Y, somatostatin and parvalburnin levels in hippocampal interneurons by neuronal activity and BDNF." In Progress in Brain Research. Elsevier, 2000. http://dx.doi.org/10.1016/s0079-6123(00)28017-5.

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