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Harguindéguy, Jean-Baptiste, and Zoé Bray. "Does Cross-Border Cooperation Empower European Regions? The Case of Interreg III-A France–Spain." Environment and Planning C: Government and Policy 27, no. 4 (August 2009): 747–60. http://dx.doi.org/10.1068/c08119.
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In this paper we investigate the impact of the implementation of EU programmes on substate actors, and more specifically regional ones. We focus on the case of the INTERREG cross-border initiative in France and Spain between 2000 and 2003, and whether INTERREG succeeded in empowering regional governments and local authorities as it initially claimed to. Our analysis puts to the fore that this programme has not evolved from being ‘a policy for the regions to a policy by the regions' as many expected, but that its implementation rather reveals a wide range of configurations. Indeed, the execution of INTERREG facilitated the transition from a state-centric scheme to a regionalised one only in those territories where a previous decentralisation policy had been realised at the domestic level and where a consistent regional leadership had emerged during earlier versions of INTERREG.
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Padová, Zuzana. "Evaluation of Implementation of Projects Community Interactive Interreg III A." Geografické informácie 16, no. 2 (2012): 77–88. http://dx.doi.org/10.17846/gi.2012.16.2.77-88.
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Harguindéguy, Jean-Baptiste. "Cross-border Policy in Europe: Implementing INTERREG III-A, France–Spain." Regional & Federal Studies 17, no. 3 (September 2007): 317–34. http://dx.doi.org/10.1080/13597560701543717.
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Laffan, Brigid, and Diane Payne. "INTERREG III and cross‐border cooperation in the Island of Ireland." Perspectives on European Politics and Society 4, no. 3 (September 2003): 447–73. http://dx.doi.org/10.1080/15705850308438872.
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Laffan, Brigid, and Diane Payne. "The EU in the Domestic: Interreg III and the Good Friday Institutions." Irish Political Studies 17, no. 1 (June 2002): 74–96. http://dx.doi.org/10.1080/714003146.
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Mesarec, Beno, and Marjan Lep. "COMBINING THE GRID‐BASED SPATIAL PLANNING AND NETWORK‐BASED TRANSPORT PLANNING." Technological and Economic Development of Economy 15, no. 1 (March 31, 2009): 60–77. http://dx.doi.org/10.3846/1392-8619.2009.15.60-77.
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Border regions of EU countries are confronted with changes of spatial and economical development. The lack of border crossing strategic information system for regional planning purposes reflects in non‐intense cooperation in the field of regional development strategies harmonization. The article presents the methodology developed during Interreg III B project REDECON. Grid‐based database with GIS interface, merging socio‐economic, environmental and spatial data with vector‐based network accessibility data, what enable the public planning departments to analyze and simulate different policy measures concerning transport. The article is focused on the modifications of (during project REDECON) developed methodology, which enable besides cross‐border spatial analysis also analysis of current status of public transport demand and supply for finding the areas, where the supply of public transport services does not reach the demand for public transport services. It describes the methodology for selecting the main indicator thematic groups for different public transport demand types, the characterization (evaluation) of suitability of locations in respect to the balance between public transport supply and demand. At the end of the article the results of methodology application are presented on the regional pilot project concerning accessibility of pilot area, regional public transport demands and regional optimization of the public transport supply. Santrauka Aprašoma Redecon metodika, sukurta vykdant tarptautinio projekto Interreg III B metu. Tinklelinė duomenų bazė, paremta geografinėmis informacinėmis sistemomis, suvienijo socialinius ir ekonominius, aplinkosaugos, erdvinius ir vektorinius pasiekiamumo duomenis. Visa tai leido viešojo transporto planuotojams lengviau analizuoti ir modeliuoti transporta skirtingomis priemonėmis. Straipsnyje aprašomoji sukurtos metodikos modifikacija, padedanti nagrineti transporto sistemos paklausa, parodo, kuriose teritorijose viešojo transporto aprūpinimas nepakankamas ir pan. Pabaigoje svarstoma, kokiam regionui galima pritaikyti šią metodiką, to regiono viešojo transporto paklausą ir optimizavimą.
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Prokkola, Eeva-Kaisa. "Cross-Border Regionalization, the INTERREG III a Initiative, and Local Cooperation at the Finnish-Swedish Border." Environment and Planning A: Economy and Space 43, no. 5 (May 2011): 1190–208. http://dx.doi.org/10.1068/a43433.
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Socal, Giorgio, Raffaella Casotti, and Alenka Malej. "The Northern Adriatic Sea: selected results from the European program INTERREG III Italy-Slovenia (2000-2006)." Marine Ecology 29, no. 3 (September 2008): 365–66. http://dx.doi.org/10.1111/j.1439-0485.2008.00258.x.
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García-Sánchez, Soraya, and Carmen Luján-García. "Lifelong Learning and ESP Vocabulary: Reflections in Telecommunications and ICT." ELOPE: English Language Overseas Perspectives and Enquiries 17, no. 2 (November 16, 2020): 195–218. http://dx.doi.org/10.4312/elope.17.2.195-218.
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This paper examines the building of a glossary of technical terms by a sample of master’s degree students in the professional field of Telecommunications Engineering. To achieve this aim, linguistic data was extracted from the European MACbioIDi INTERREG Project with the aim of creating a collaborative bilingual, English- Spanish glossary. The glossary is used to foster vocabulary learning strategies for ELF/ESP learners and teachers of English. The study, designed for lifelong learning education and set in an ESP context of ICT and Telecommunications, shows (i) how a glossary building task can take the form of collaborative and reflective vocabulary learning projects in ESP, (ii) the learners’ identification of anglicisms in their professional domains, and (iii) samples of writing products stemming from building the glossary.
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Prokkola, Eeva-Kaisa. "Regionalization, Tourism Development and Partnership: The European Union's North Calotte Sub-programme of INTERREG III A North." Tourism Geographies 13, no. 4 (November 2011): 507–30. http://dx.doi.org/10.1080/14616688.2011.570371.
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Jaržemskis, Andrius, and Aidas Vasilis Vasiliauskas. "RESEARCH ON DRY PORT CONCEPT AS INTERMODAL NODE." TRANSPORT 22, no. 3 (September 30, 2007): 207–13. http://dx.doi.org/10.3846/16484142.2007.9638126.
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The shortage of the free space in the port areas is the reason to search for alternatives. This paper focuses on the dry port concept which is a new approach to solving the mentioned problem. The dry port concept is based on moving of intermodal terminals further to hinterland from the port areas. It helps to avoid traffic bottlenecks, to connect cargo handling from the port with other types of cargo at one common transport centre and it can help develop the hinterland areas. The BSR Interreg III B NP project Inloc (Integrating logistics centre networks in the Baltic Sea Region) showed an initiative to elaborate the concept and to study the feasibility to attract transport operators. The research was done partly by the authors of the article – partners of the Inloc project. Common results of the dry port research and conclusions of the approach elaborated by the article authors are presented.
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Tomasi, Silvia, Alyona Zubaryeva, Cesare Pizzirani, Margherita Dal Col, and Jessica Balest. "Propensity to Choose Electric Vehicles in Cross-Border Alpine Regions." Sustainability 13, no. 8 (April 20, 2021): 4583. http://dx.doi.org/10.3390/su13084583.
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Electric vehicles (EVs) are low-carbon innovations that decrease emissions in transportation. Understanding what drives individual propensity to choose EVs supports policymakers in shaping effective low-carbon mobility policies. Within the MOBSTER Interreg project, data were collected using a survey administered to residents in three Alpine cross-border regions—Canton Ticino (Switzerland), South Tyrol (Italy), and Verbano-Cusio-Ossola (Italy)—and were analyzed with a logistic regression. This study reports on the relevant drivers of EV uptake, showing (i) that some sociodemographic attributes positively impact the propensity to choose an EV (e.g., young age and teenage children), (ii) that the presence and visibility of charging infrastructures are important, and (iii) that the role of tourism is not a driver of EV uptake. This study confirms that policies should consider sociodemographics, social practices, and physical infrastructures as playing roles in EV uptake. Future research should address the issue of access to low-carbon innovations for all.
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Rubino, Fernando, Salvatore Moscatello, Manuela Belmonte, Gianmarco Ingrosso, and Genuario Belmonte. "Plankton Resting Stages in the Marine Sediments of the Bay of Vlorë (Albania)." International Journal of Ecology 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/101682.
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In the frame of the INTERREG III CISM project, sediment cores were collected at 2 stations in the Gulf of Vlorë to study the plankton resting stage assemblages. A total of 87 morphotypes were identified and produced by Dinophyta, Ciliophora, Rotifera, and Crustacea. In 22 cases, the cyst belonged to a species absent from the plankton of the same period. The most abundant resting stages were those produced byScrippsiellaspecies (Dinophyta). Some calcareous cysts were identified as fossil species associated with Pleistocene to Pliocene sediment, although they were also found in surface sediments and some of them successfully germinated, thus proving their modern status. Total abundance generally decreased with sediment depth at station 40, while station 45 showed distinct maxima at 3 and 8 cm below the sediment surface. The depth of peak abundance in the sediment varied with species. This paper presents the first study of the plankton resting stages in the Bay of Vlorë. The study confirmed the utility of this type of investigation for a more correct evaluation of species diversity. In addition, the varying distribution with sediment depth suggests that this field could be of some importance in determining the history of species assemblages.
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Manfra, Loredana, Claudia Virno Lamberti, Silvia Ceracchi, Giordano Giorgi, Daniela Berto, Marina Lipizer, Michele Giani, et al. "Challenges in Harmonized Environmental Impact Assessment (EIA), Monitoring and Decommissioning Procedures of Offshore Platforms in Adriatic-Ionian (ADRION) Region." Water 12, no. 9 (September 1, 2020): 2460. http://dx.doi.org/10.3390/w12092460.
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A harmonized and integrated approach for monitoring and assessment of contamination, including hydrocarbon exploitation one, is required both by Marine Strategy Framework Directive (MSFD) at EU level and by the Ecosystem Approach (EcAp) program of the Barcelona Convention at Mediterranean level. A broad review of protocols of environmental impact assessment (EIA) procedures, monitoring and decommissioning of offshore platforms adopted by EU and non-EU countries along the Adriatic-Ionian seas was carried out in the framework of the Interreg offshore platforms in Adriatic-Ionian (ADRION) project HarmoNIA (Harmonization and networking for contaminant assessment in the Ionian and Adriatic Seas). The comparison of information provided by six ADRION countries and the application of a harmonized and integrated approach has highlighted specific challenges for managing offshore platform impacts emerged at ADRION level: (i) need of the same legislative level (the Offshore Protocol of Barcelona Convention is not ratified by all countries); (ii) set up of a task force of ADRION experts for discussing critical issues related to impacts of offshore platforms; (iii) harmonization, at the regional level, of EIA procedures, monitoring and decommissioning; (iv) need of an agreed and common list of recommended parameters to monitor in water, sediment and biota for the assessment of impacts due to platform installations and PFW discharges.
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Cocchi, Monia, Patrizia Danesi, Gabrita De Zan, Marta Leati, Laura Gagliazzo, Margherita Ruggeri, Manlio Palei, et al. "A Three-Year Biocrime Sanitary Surveillance on Illegally Imported Companion Animals." Pathogens 10, no. 8 (August 18, 2021): 1047. http://dx.doi.org/10.3390/pathogens10081047.
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The illegal trade of companion animals in the European Union poses several legal, ethical and health issues to the entire community. In the framework of the Biocrime Interreg project between Italy and Austria, we surveyed puppies and kittens confiscated at the borders to identify the most frequent pathogens associated with (i) the risk of spread within the shelter, (ii) the development of fatal disease and (iii) the zoonotic potential. From January 2018 to December 2020, we examined a total of 613 puppies and 62 kittens coming from 44 requisitions. Feces, skin specimens and blood sera from confiscated animals were tested to verify the presence of major infections and to assess the rabies post-vaccination immunity. Out of the total of individuals under investigation, necropsies and laboratory investigations were also performed on 79 puppies and three kittens that had died during the observation period. Results indicated a high prevalence of Canine Parvovirus (CPV) and Giardia spp. infections, CPV as the most likely cause of fatal gastroenteritis in puppies and Salmonella and Microsporum canis as major zoonotic pathogens. Conversely, both extended spectrum beta lactamases Escherichia coli and methicillin resistant Staphylococcus pseudintermedius strains as rare findings. Results highlighted that illegal animal trade could expose the human population to potential zoonotic risk and naïve animal population to potentially disrupting epidemic waves, both of these issues being largely underestimated when buying companion animals.
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Márquez Domínguez, Juan Antonio, José Manuel Jurado Almonte, and Francisco José Pazos García. "La cooperación transfronteriza luso-andaluza. Un camino difícil = Luso-andalusian cross-border cooperation. A difficult road." Polígonos. Revista de Geografía, no. 29 (November 29, 2017): 89. http://dx.doi.org/10.18002/pol.v0i29.5202.
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<p>Durante siglos, la persistencia de relaciones contradictorias entre las comunidades locales de la Raya ibérica y los poderes estatales y regionales de la frontera ha conformado un desarrollo difícil para la cooperación transfronteriza. En su territorio, el despoblamiento, el retroceso de la agricultura, el desmantelamiento de la industria local y la precariedad de los servicios fueron creando un espacio en crisis, un espacio perdedor, en términos de darwinismo territorial. Sin embargo, desde hace unas décadas, en un nuevo marco institucional de cooperación entre los Estados de la Unión Europea, aparecen programas y fórmulas que intentan favorecer a los territorios de la frontera. Su implantación ha conseguido mejorar algunos elementos estructurantes, ya sean, puentes, carreteras, puertos y otras infraestructuras, pero no consiguen desterrar graves problemas de despoblamiento y atonía económica en la mayor parte del territorio rayano. Como hipótesis de partida, creemos que las políticas de cooperación transfronteriza han beneficiado a las estructuras políticas del Algarve, Alentejo y Andalucía, pero no han repercutido en el desarrollo de la Raya, ni en su gobernanza, ni en su dinamización productiva. Antes bien, los espacios fronterizos han aumentado su grado de marginalidad territorial con respectos a centros urbanos muy alejados de su problemática como pueden ser Lisboa y Sevilla. En consecuencia, el objetivo de este artículo es conocer y evaluar los efectos de los programas de cooperación transfronteriza de la Unión Europea en el ámbito de la Eurorregión conformada por Andalucía, Algarve y Alentejo, en las escalas regionales y en los espacios de frontera, especialmente desde el año 2000, cuando el programa INTERREG III comenzó a tener alguna repercusión en la cooperación transfronteriza.</p><p> </p><p>The persistence of contradictory relationships between the local communities of the Iberian Raya and state and regional authorities of the border has formed a difficult development for this territory, where depopulation, the decline of agriculture, dismantling of local industry and precariousness of services are creating a space in crisis, a loser space in terms of territorial Darwinism. In a new institutional framework for cooperation between the States of the European Union, a few decades ago new programs and formulas have appeared, trying to stimulate cross-border territories. Its implementation has improved some structural elements (bridges, ports and other infrastructures) but can not completely eradicate the serious structural problems of most of this frontier area. As hypothesis we believe that the policies of cross-border cooperation have benefited the political structures of the Algarve, Alentejo and Andalusia, but have not had repercussions in the improvement of the governance nor the development of border areas, which have increased their degree of territorial marginality respect to the nearest urban centres (Lisbon and Seville) and continue losing population. Therefore, the objective of this paper is to understand and assess the effects of cross-border cooperation programs of the European Union in the area of this AAA Euroregion, on regional scales and on border spaces, especially from the INTERREG III (2000-2006).</p>
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Rogers, Alan R., Nathan S. Harris, and Alan A. Achenbach. "Neanderthal-Denisovan ancestors interbred with a distantly related hominin." Science Advances 6, no. 8 (February 2020): eaay5483. http://dx.doi.org/10.1126/sciadv.aay5483.
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Previous research has shown that modern Eurasians interbred with their Neanderthal and Denisovan predecessors. We show here that hundreds of thousands of years earlier, the ancestors of Neanderthals and Denisovans interbred with their own Eurasian predecessors—members of a “superarchaic” population that separated from other humans about 2 million years ago. The superarchaic population was large, with an effective size between 20 and 50 thousand individuals. We confirm previous findings that (i) Denisovans also interbred with superarchaics, (ii) Neanderthals and Denisovans separated early in the middle Pleistocene, (iii) their ancestors endured a bottleneck of population size, and (iv) the Neanderthal population was large at first but then declined in size. We provide qualified support for the view that (v) Neanderthals interbred with the ancestors of modern humans.
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Amengual, A., T. Diomede, C. Marsigli, A. Martín, A. Morgillo, R. Romero, P. Papetti, and S. Alonso. "A hydrometeorological model intercomparison as a tool to quantify the forecast uncertainty in a medium size basin." Natural Hazards and Earth System Sciences 8, no. 4 (August 5, 2008): 819–38. http://dx.doi.org/10.5194/nhess-8-819-2008.
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Abstract. In the framework of AMPHORE, an INTERREG III B EU project devoted to the hydrometeorological modeling study of heavy precipitation episodes resulting in flood events and the improvement of the operational hydrometeorological forecasts for the prediction and prevention of flood risks in the Western Mediterranean area, a hydrometeorological model intercomparison has been carried out, in order to estimate the uncertainties associated with the discharge predictions. The analysis is performed for an intense precipitation event selected as a case study within the project, which affected northern Italy and caused a flood event in the upper Reno river basin, a medium size catchment in the Emilia-Romagna Region. Two different hydrological models have been implemented over the basin: HEC-HMS and TOPKAPI which are driven in two ways. Firstly, stream-flow simulations obtained by using precipitation observations as input data are evaluated, in order to be aware of the performance of the two hydrological models. Secondly, the rainfall-runoff models have been forced with rainfall forecast fields provided by mesoscale atmospheric model simulations in order to evaluate the reliability of the discharge forecasts resulting by the one-way coupling. The quantitative precipitation forecasts (QPFs) are provided by the numerical mesoscale models COSMO and MM5. Furthermore, different configurations of COSMO and MM5 have been adopted, trying to improve the description of the phenomena determining the precipitation amounts. In particular, the impacts of using different initial and boundary conditions, different mesoscale models and of increasing the horizontal model resolutions are investigated. The accuracy of QPFs is assessed in a threefold procedure. First, these are checked against the observed spatial rainfall accumulations over northern Italy. Second, the spatial and temporal simulated distributions are also examined over the catchment of interest. And finally, the discharge simulations resulting from the one-way coupling with HEC-HMS and TOPKAPI are evaluated against the rain-gauge driven simulated flows, thus employing the hydrological models as a validation tool. The different scenarios of the simulated river flows – provided by an independent implementation of the two hydrological models each one forced with both COSMO and MM5 – enable a quantification of the uncertainties of the precipitation outputs, and therefore, of the discharge simulations. Results permit to highlight some hydrological and meteorological modeling factors which could help to enhance the hydrometeorological modeling of such hazardous events. Main conclusions are: (1) deficiencies in precipitation forecasts have a major impact on flood forecasts; (2) large-scale shift errors in precipitation patterns are not improved by only enhancing the mesoscale model resolution; and (3) weak differences in flood forecasting performance are found by using either a distributed continuous or a semi-distributed event-based hydrological model for this catchment.
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Chen, Tao Ping, Chao Jiang, and Li Li Wang. "Numerical Simulation Research on Locations Optimization of Horizontal Well to Exploit Remaining Oil of Lateral Accretion Interbed after Polymerflooding." Applied Mechanics and Materials 318 (May 2013): 460–64. http://dx.doi.org/10.4028/www.scientific.net/amm.318.460.
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Conceptual models of lateral accretion interbed (the point bar lateral sandbody model contains three lateral accretion interbed .And the lateral accretion interbeds extends to two-thirds of reservoir thickness)is builded making use of numerical simulation software Eclipse. The effect of injection water on water drive recovery is analysised. The location of remaining oil enrichment is also determined. Horizontal well is placed in remaining oil enrichment and its vertical direction and horizontal hole section are optimization. Horizontal well and vertical well are combined to exploit residual oil. Results indicates that: Injectiong water in the direction of lateral accretion interbed can obtain higher water drive recovery than in the opposite direction. The closer to top the horizontal well is , the greater recovery enhancement values is.Horizontal hole section starts from the location of four-fifths of lateral sandbody I left and terminats nine-tenths of lateral sandbody III, where the recovery is highest. Horizontal well is placed after vertiacal well injecting polymer in which recovery can increase 9.8%. According to numerical simulation optimization results, we have made a physical model with lateral accretion interbeds to do experiments. Numerical simulation results agree with experimental results. Hence horizontal and vertical well uinting together can exploit the remaining oil of lateral accretion interbed effectively .
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Badham, Sally. "Edward The Confessor's Chapel, Westminster Abbey: The Origins of the Royal Mausoleum and its Cosmatesque Pavement." Antiquaries Journal 87 (September 2007): 197–219. http://dx.doi.org/10.1017/s0003581500000895.
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It has hitherto been argued that Edward the Confessor's Chapel at Westminster Abbey, built by Henry III in 1246–59, was established as the royal mausoleum only from the 1290s. In 2005 a ground penetrating radar survey of the chapel floor revealed many anomalies, some of which can be interpreted as grave cists. A re-examination of the written and physical evidence for subfloor burials in the chapel suggests that, among other early burials, at least five of Edward I's children were interred here in the period 1264–84. It thus appears that the chapel was used as a family mausoleum before 1290 and was not originally exclusively reserved for the monarchs and their consorts. New light is also thrown on the vexed question of the date of the Cosmatesque floor in the shrine chapel, which is here redated to the 1290s.
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FitzPatrick, Elizabeth. "THE EXILIC BURIAL PLACE OF A GAELIC IRISH COMMUNITY AT SAN PIETRO IN MONTORIO, ROME." Papers of the British School at Rome 85 (July 27, 2017): 205–39. http://dx.doi.org/10.1017/s006824621700006x.
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This paper presents the findings of a survey of the funerary monuments and burial vault of an exiled community of Gaelic Irish who were interred (1608–23) at San Pietro in Montorio, Rome. The site of their burial and commemoration had an eventful history that resulted in loss, fragmentation and alteration of the ledgers of élite members of the group, including those of the respective chiefs and earls of the Ulster lordships of Tyrone and Tyrconnell in Ireland. The original form and layout of the ledgers and their inscriptions is proposed and they are examined in the context of their setting in a Franciscan church patronized by Philip III of Spain. The ledger inscriptions commemorate both the suffering and Counter-Reformation confessional identity of the Gaelic Irish as Catholic exiles. They indicate tension between the complex political circumstances of the exiles’ lives in Rome and a concern to provide an appropriate burial site publicly reflecting their status and piety.
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Ghaffarzadeh, Hooman, and Ali Mehrizi-Sani. "Review of Control Techniques for Wind Energy Systems." Energies 13, no. 24 (December 17, 2020): 6666. http://dx.doi.org/10.3390/en13246666.
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In recent years, penetration of renewable energy resources into the power grid has increased significantly. Wind, as a renewable, clean, and abundantly available source of energy, has an important share in the energy mix. However, increasing the penetration of wind power in the power grid can adversely affect the power quality and introduce new operational challenges. This paper discusses issues related to the integration of wind farms in the power system, such as maximum power point tracking, fault ride-through capabilities, interarea and subsynchronous oscillations, and voltage flicker, and provides a review of the existing control strategies to address these issues in Types I, II, III, and IV wind turbines. This paper also identifies challenges and opportunities ahead.
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Nagy, Péter L., Judit Olasz, Endre Neparáczki, Nicholas Rouse, Karan Kapuria, Samantha Cano, Huijie Chen, et al. "Determination of the phylogenetic origins of the Árpád Dynasty based on Y chromosome sequencing of Béla the Third." European Journal of Human Genetics 29, no. 1 (July 7, 2020): 164–72. http://dx.doi.org/10.1038/s41431-020-0683-z.
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AbstractWe set out to identify the origins of the Árpád Dynasty based on genome sequencing of DNA derived from the skeletal remains of Hungarian King Béla III (1172–1196) and eight additional individuals (six males, two females) originally interred at the Royal Basilica of Székesfehérvár. Y-chromosome analysis established that two individuals, Béla III and HU52 assign to haplogroups R-Z2125 whose distribution centres near South Central Asia with subsidiary expansions in the regions of modern Iran, the Volga Ural region and the Caucasus. Out of a cohort of 4340 individuals from these geographic areas, we acquired whole-genome data from 208 individuals derived for the R-Z2123 haplogroup. From these data we have established that the closest living kin of the Árpád Dynasty are R-SUR51 derived modern day Bashkirs predominantly from the Burzyansky and Abzelilovsky districts of Bashkortostan in the Russian Federation. Our analysis also reveals the existence of SNPs defining a novel Árpád Dynasty specific haplogroup R-ARP. Framed within the context of a high resolution R-Z2123 phylogeny, the ancestry of the first Hungarian royal dynasty traces to the region centering near Northern Afghanistan about 4500 years ago and identifies the Bashkirs as their closest kin, with a separation date between the two populations at the beginning of the first millennium CE.
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Argos, João Esteiam De. "Wine and stone: Dionysus and the material expression of the theater on the urbanism of archaic and classical Greece." Revista do Museu de Arqueologia e Etnologia. Suplemento, supl.12 (October 28, 2011): 23. http://dx.doi.org/10.11606/issn.2594-5939.revmaesupl.2011.113565.
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O objetivo desta pesquisa é buscar uma melhor compreensão do papel desempenhado pelo culto de Dioniso na cidade grega da época arcaica e clássica. Partimos do princípio de que o teatro como instituição grega expressa a presença do culto de Dioniso na pólis e de que o ambiente construído expressa elementos organizacionais da sociedade e interage com ela. Nossa intenção é, a partir de uma amostragem definida, estudar o teatro grego em seus aspectos físicos/materiais, focalizando sua inserção no disciplinamento do espaço na cidade-estado grega. Ainda que seja impossível ignorar a documentação escrita e a bibliografia existente sobre o teatro grego na Atica, pretendemos ampliar a nossa perspectiva, lidando com material arqueológico proveniente de outras pólis. Nosso recorte cronológico estará constituído pelos séculos VI ao III a.C
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Umemura, S., K. Fujiwara, M. Tabata, T. Kishimoto, K. Gemba, T. Kodani, N. Takigawa, K. Kiura, H. Ueoka, and M. Tanimoto. "Use of epigenetic aberrant promoter methylation in serum DNA for detection of pneumoconiosis-associated lung cancer." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 20059. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.20059.
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20059 Background: Pneumoconiosis is known to be associated with an independent increased risk of lung cancer. However, it is difficult to detect lung cancer radiographically in patient with pneumoconiosis because of pre-existing diffuse pulmonary shadows. The purpose of this study is to evaluate the usefulness of serum DNA methylation for detection of pneumoconiosis-associated lung cancer. Methods: We investigated to identify promoter methylation status of RAR-beta, p16INK4a, MGMT, DAPK, and RASSFIA gene in serum DNA using methylation-specific PCR. Sera were obtained from 31 control patients with non-malignant-non-pneumoconiotic pulmonary disease (Group I), 36 with pneumoconiosis (Group II), and 5 with pneumoconiosis-associated lung cancer (Group III). DNA was extracted using QIAamp DNA Blood Midi Kit (Qiagen, CA). Following DNA bisulfite modification using CpGenome DNA Modification Kit (Intergen, NY), PCR was performed with primers for methylated or unmethylated promoter sequences. Results: Median (range) age of patients were 61 (26–78), 71 (49–86), and 69 (56–78) for Group I, II, and III respectively. Median (range) duration of silica and asbestos exposure were 33 (3–47) years and 33(32–40) years for Group II and III respectively. All of 5 pneumoconiosis-associated lung cancer were adenocarcinoma. Eleven patients (35.5%) in Group I, 19 patients (52.8%) in Group II, and 5 patients (100%) in Group III were shown to have methylation of at least one gene. The total number of methylated genes per patient were, 0.35, 0.69, and 1.20 for groups I, II, and III respectively (p = 0.013, Kruskal-Wallis analysis). In Group II, methylation status did not correlate with duration of occupational exposure, smoking history, radiographic findings, and age. Conclusions: In patients with pneumoconiosis, monitoring of aberrant promoter methylation of serum DNA might be useful for assessing the risk of lung cancer and early detection of lung cancer. No significant financial relationships to disclose.
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Magina, Sandra Maria Pinto. "Editorial JIEEM v. 10, n. 2, 2017." Jornal Internacional de Estudos em Educação Matemática 10, no. 2 (August 31, 2017): 61. http://dx.doi.org/10.17921/2176-5634.2017v10n2p61-64.
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Este número especial do periódico Jornal Internacional de Estudos em Educação Matemática - JIEEM traz os artigos elaborados pelos pesquisadores que compuseram o grupo de palestrantes do III Simpósio Brasileiro de Psicologia da Educação Matemática - SBPEM, realizado em 2016. Este simpósio aconteceu na Universidade Estadual de Santa Cruz - UESC, em Ilhéus, organizado pelo Programa de Pós-Graduação em Educação Matemática - PPGEM, com colaboração do Núcleo de Pesquisa em Psicologia da Educação Matemática - NUPEM. O seu objetivo foi discutir a contribuição da Psicologia para a Educação Matemática para um ensino de qualidade na educação básica, no sentido de tornar significativa a aprendizagem dos estudantes, com impacto em seu desenvolvimento pessoal e em sua inserção social.O Simpósio teve ainda como objetivos específicos: (i) promover discussões de natureza teórica acerca da contribuição da Psicologia para a Educação Matematica; (ii) promover discussões de natureza empírica derivadas de pesquisas no campo da Psicologia da Educação Matemática ou que com ele interage; (iii) promover discussões sobre temas atuais e relevantes para o ensino, aprendizagem e avaliação do conhecimento matemático; (iv) promover o intercâmbio entre pesquisadores de renome nacional e, desses, com pesquisadores estrangeiros de renome internacional, que de várias formas dialogam com a Psicologia da Educação Matemática.
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Kaczorowski, Włodzimierz. "Primate Jan Wężyk in the Role of Interrex and Senator of the Polish-Lithuanian Commonwealth in the Period of Interregnum Following the Death of Sigismund III Vasa in 1632." Kościół i Prawo 10, no. 1 (July 21, 2021): 175–93. http://dx.doi.org/10.18290/kip21101-10.
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Prymas Jan Wężyk w roli interreksa oraz senatora Rzeczypospolitej w okresie bezkrólewia po śmierci Zygmunta III Wazy w 1632 roku
W Rzeczypospolitej Obojga Narodów prymas, a zarazem arcybiskup gnieźnieński po śmierci monarchy przejmował obowiązki w zakresie reprezentowania państwa na zewnątrz, przygotowywał wybór nowego króla i w tym celu zwoływał sejmiki orz sejm konwokacyjny. Prymas wreszcie ogłaszał wybór elekta, czyli dokonywał nominacji.
Po śmierci Zygmunta III Wazy w 1632 r. funkcję interreksa w okresie bezkrólewia pełnił prymas Jan Wężyk (1575-1638). Z funkcji tej wywiązał się znakomicie. Sprawowane prze niego urzędy postawiły go w rzędzie osób, które wpływały na kształt Rzeczypospolitej i Kościoła. Za prymasostwa Jana Wężyka częściowo rozwiązano sprawę compositio inter status, od kilkudziesięciu lat ciążącą na stosunkach szlachty z duchowieństwem. Prymas Jan Wężyk był również mecenasem kultury i sztuki.
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Cruz, Cristiano Pimentel, Bruno Gonçalves Carneiro, and Karylleila Dos Santos Andrade. "Gírias na língua de sinais brasileira e seus contextos de uso." Revista Linguíʃtica 16, no. 3 (December 30, 2020): 103–27. http://dx.doi.org/10.31513/linguistica.2020.v16n3a36958.
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Este artigo é uma pesquisa sobre o uso de gírias por um grupo de surdos, na cidade de Palmas - TO, que interage através da rede social WhatsApp. Nesta pesquisa, fizemos o levantamento de dezenove gírias e descrevemos o perfil dos participantes, as regras de manutenção do grupo e o processo de criação dos sinais. O suporte teórico e metodológico utilizado para este estudo foi dos autores Preti (2000a; 2000b; 2003; 2013) e Murata (2008), sobre as gírias enquanto prática de linguagem de resistência, oposição e proteção. No grupo, a troca de informações acontece em libras (vídeo) e não há participação de ouvintes. Segundo os participantes, as gírias surgem como formas: (i) de entretenimento e humor, em um ambiente em que estão à vontade em relação à língua e aos temas abordados, (ii) de resistência, numa oposição às experiências negativas frente à sociedade majoritária e (iii) de proteção e sigilo, frente aos ouvintes sinalizantes e a outros surdos membros da comunidade surda. As gírias são categorizadas em: (i) sinais inéditos, (ii) sinais com parâmetros modificados (configuração de mão) para expressar intensidade, (iii) sinais com parâmetros modificados (orientação da palma) para indicar ironia e (iv) sinais com parâmetros modificados (ponto de articulação) para evidenciar a modalidade gestual-visual das línguas de sinais. Os resultados da pesquisa também indicam que o processo de criação das gírias envolve a lexicalização de ações gestuais, originando sinais altamente icônicos, e a alteração de unidades sub-lexicais, caracterizando os parâmetros como fonomorfemas.
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Salwa, Salwa, Mujtahid Bin Abd Kadir, and Yuni Sulistyowati. "FORMULASI DAN EVALUASI SEDIAAN SPRAY GEL TABIR SURYA FRAKSI ETIL ASETAT DAUN CEMPEDAK (Artocarpus integer (Thunb.) Merr.) DENGAN KOMBINASI BASIS HPMC DAN KARBOPOL 940." Jurnal Mahasiswa Kesehatan 2, no. 1 (October 31, 2020): 12. http://dx.doi.org/10.30737/jumakes.v2i1.1222.
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Daun cempedak memiliki aktivitas antioksidan dan mengandung metabolit sekunder berupa senyawa flavonoid yang diketahui mempunyai potensi sebagai tabir surya karrena adanya gugus kromoofor (ikatan rangkap tunggal terkonjugasi) yang mapu menyerap sinar UV. Bentuk sediaan Spray gel merupakan pengembangan dari bentuk sediaan gel yang memiliki tingkat kontaminasi rendah, waktu kontak yang lebih lama dan lebih praktis digunakan. Oleh karena itu, pada penelitian ini akan dilakukan formulasi sediaan spray gel dengan fraksi etil asetat daun cempedak (Artocarpus interger (Thunb.)Merr.). Pada penelitian ini dilakukan formulasi sediaan spray gel dengan variasi perbandingan konsentrasi basis HPMC dan Karbopol 940 berturut-turut (0,5:0,5);(0,5:1,0) dan (1,0:0,5). Sediaan yang dibuat kemudian dilakukan evaluasi fisik yang terdiri dari uji organoleptik, homogenitas, pH, viskositas, dan pola penyemprotan. Sedangkan untuk aktivitas tabir surya dilakukan pengujian nilai SPF secara in vitro. Berdasarkan hasil pengujian yang dilakukan didapatkan bahwa formula I memurpakan formula yang paling optimal diantara ketiga formula dengan perbandingan konsentrasi basis HPMC dan karbopol 940 0,5:0,5. Sedangkan pada penentuan nilai SPF diketaruhi sediaan yang memiliki nilai SPF dari yang tertinggi hingga terrendah berturut-turut yaitu formula I (2,186); formula II (2,141) dan formula III (1,870). Kata Kunci : SPF (Sun Protection Factor), Daun cempedak, Artocarpus integer (Thunb.) Merr., Antioksidan, Spray gel
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Grande, Catarina, and Ana Isabel Pinto. "O envolvimento de crianças com necessidades educativas especiais em contexto de creche e de jardim-de-infância." Análise Psicológica 29, no. 1 (November 23, 2012): 99–117. http://dx.doi.org/10.14417/ap.42.
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Este estudo pretende analisar o envolvimento observado em 50 crianças com incapacidades integradas em contexto de creche/jardim-de-infância da Área Metropolitana do Porto, comparando os níveis e tipos de envolvimento observado em dois contextos de actividade: na presença da educadora da educação especial e na sua ausência. O perfil de incapacidade das crianças foi obtido com base no Índex de Capacidades (Simeonsson & Bailey, 1991) e os dados de envolvimento observado foram obtidos através da aplicação do Engagement Quality Observation System III (McWilliam & de Kruif,1998). Centrando-se nas competências interactivas da criança em situações de jogo ou em actividades de rotina, o envolvimento tem sido estudado como um factor de aprendizagem e desenvolvimento que ilustra as experiências diárias da criança, bem como a qualidade das oportunidades que lhe são proporcionadas nos seus contextos educativos.Os resultados indicam que a sofisticação, bem como o foco de envolvimento da criança são influenciados por características da criança (idade e grau de incapacidade), bem como por factores do meio educativo em que ela interage (presença da educadora de educação especial), sublinhado a relevância desta linha de investigação e fornecendo evidência empírica acerca do constructo de envolvimento enquanto indicador de processos interactivos com valor desenvolvimental
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Jumadilov, T. K., R. G. Kondaurov, Zh A. Abilov, J. V. Grazulevicius, and A. A. Akimov. "Influence of polyacrylic acid and poly-4-vinylpyridine hydrogels mutual activation in intergel system on their sorption properties in relation to lanthanum (III) ions." Polymer Bulletin 74, no. 11 (March 20, 2017): 4701–13. http://dx.doi.org/10.1007/s00289-017-1985-3.
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Richardson, Philip, and F. H. H. King. "The History of the Hongkong and Shanghai Banking Corporation, III, The Hongkong Bank between the Wars and the Bank Interned, 1919-1945: Return from Grandeur." Economic History Review 43, no. 1 (February 1990): 165. http://dx.doi.org/10.2307/2596546.
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Paletta, Francisco Carlos, and José Antonio Moreiro Gonzalez. "Modelos de busca, acesso, recuperação e apropriação da informação na web de dados." Informação & Informação 24, no. 2 (November 30, 2019): 182. http://dx.doi.org/10.5433/1981-8920.2019v24n2p182.
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Introdução: A era digital demanda por novas propostas e abordagens técnicas associadas à utilização da Tecnologia da Informação na recuperação e apropriação da informação no contexto da Web de Dados. O desenvolvimento dessa área permitirá um maior entendimento dos recursos da tecnologia colaborativa utilizados em ambientes informacionais digitais na organização da informação e do conhecimento. A inserção dessas tecnologias consiste em inovações que devem estar vinculadas à tradição e à missão das bibliotecas e dos repositórios digitais. Objetivos: Este trabalho tem por objetivo discutir os resultados parciais de projeto de pesquisa conduzido no Departamento de Informação e Cultura da Escola de Comunicações e Artes da Universidade de São Paulo e está estruturado em três fases: (i) Modelos de busca, acesso, e recuperação da informação; (ii) Infraestrutura tecnológica em bibliotecas digitais; e (iii) Ferramentas de busca e recuperação da informação na Web de Dados. Metodologia: Identificar e discutir as tendências nos modelos de busca da informação, em especial interesse aqueles que influenciam o contexto da organização e recuperação da informação, de modo que o uso da tecnologia possa proporcionar a criação e agregação de valor aos modelos de busca, acesso, recuperação e apropriação da informação na Web de Dados. Conclusões: Atualmente se conhece muita coisa sobre planejamento, aquisição, organização, controle e desenvolvimento de coleções, mas muito pouco sobre como o usuário interage com os sistemas ou para que fins, e como a informação, que é a matéria-prima do sistema, está sendo utilizada. Torna-se evidente a necessidade de aprofundar os estudos e pesquisas que permitam entender os modelos de busca e apropriação da informação em um cenário dependente de recursos computacionais na Web inteligente.
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Zehou, O., L. Valeyrie-Allanore, E. Sbidian, S. Bastuji-Garin, S. Ferkal, P. Brugières, S. Barbarot, J. F. Stalder, P. Combemale, and P. Wolkenstein. "Essai multicentrique (phase IIa) ouvert évaluant l’évérolimus en monothérapie dans le traitement des neurofibromes internes non opérables au cours de la neurofibromatose 1." Annales de Dermatologie et de Vénéréologie 142, no. 12 (December 2015): S427—S428. http://dx.doi.org/10.1016/j.annder.2015.10.016.
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LeBouthillier, Yves. "Irrégularités internes et efficacité internationale de la nationalité. Par Carlo Santulli. Paris: Libraire Générale de Droit et de Jurisprudence, 1995. Pp. iii, 97. ISBN 2-275-00124-7. F.Fr 90." Canadian Yearbook of international Law/Annuaire canadien de droit international 36 (1999): 529–34. http://dx.doi.org/10.1017/s0069005800007049.
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Link, Brian K., James R. Cerhan, Hildy Dillon, Charles M. Farber, Susan Feliciano, Jonathan W. Friedberg, John Hainsworth, Ron Steis, Julie M. Vose, and Andrew D. Zelenetz. "Prospective Validation of the FLIPI: Baseline Distribution and Correlates in Newly Diagnosed Follicular Lymphoma (FL) Patients from the US: First Report of the National LymphoCare Study." Blood 106, no. 11 (November 16, 2005): 1000. http://dx.doi.org/10.1182/blood.v106.11.1000.1000.
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Abstract Background: FL comprises one quarter of lymphoma in the United States, presents in a heterogeneous fashion, and generates substantial debate regarding optimal management strategies. The recently published clinical prognostic index (FLIPI, BLOOD104:1258) facilitates outcome evaluation and may guide therapeutic strategy. The National LymphoCare Study (NLCS) is an ongoing disease-based longitudinal observational study designed to assess patterns of initial disease presentation including prognosis, long term treatment choices, and clinical outcomes in FL patients. Methods: Beginning March, 2004, pts were recruited from U.S. community practices and academic centers. Pts with FL diagnosed within 6 months with no prior lymphoma history are eligible for enrollment. Collected data includes histology, staging and prognostic evaluation, serial management strategies including drug choices but not doses, response to treatment, and events including relapses and death. There is no study-specific prescribed treatment regimen or intervention. The treating physician determines management for FL according to clinical judgment. Results: 992 pts were enrolled from 207 sites through April, 2005. 182 community sites enrolled 86% of subjects. Pt characteristics include median age 62y, 52.5% female, 90.6% Caucasian, 40% Gr1, 26% Gr2, 19% Gr3, 13% NOS, with highest determined Ann Arbor stage = 17% I, 15%II, 26% III, 33%IV, 8% Unk. The demographic characteristics are similar to pts in the national SEER registry (median age 64, 51% F, 91.3% Caucasian) but clinical characteristics are notable for a higher fraction of advanced stage disease. 686/992 (69%) patients had calculable FLIPI scores based on initial investigator workup. Of factors contributing to FLIPI scores, LDH was collected by investigators in 78% of pts. When correlated with age, geography, and academic/community sites, LDH collection rates differ with 90% in academic sites vs 76% in community sites (p = .0002). Distribution of FLIPI among 686 pts with complete scores are shown in Table1, and show remarkable consistency across grades. Summary: The NLCS is an ongoing study with a large and rapidly growing database combining clinical and treatment data and is the first database investigating initial workup, prognosis, and outcomes of pts in a predominantly community based U.S. population. FL pts enrolled in NLCS are similar to those in the SEER database, and should be widely generalizable to the US population. FLIPI continues to define three distinct groups in the NLCS and is independent of histologic grade. Current evaluation patterns result in 31% incomplete FLIPI scores, suggesting this useful prognostic index is underutilized. FLIPI distribution (%) Low 36 37 37 38 34 81 14 Intermed 37 31 32 28 37 14 40 High 27 32 31 34 29 5 46 Solal Celigny n=1795 NLCS n=686 NLCS Gr1 n=276 NLCS Gr2 n=188 NLCS Gr3 n=136 Stage I/II n=234 Stage III/IV n=452
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Phillips, Adrienne A., Iuliana Shapira, Robert D. Willum, Jasotha Sanmugarajah, William B. Solomon, Steven M. Horwitz, David G. Savage, et al. "A Critical Analysis of Prognostic Factors in Patients with HTLV-1 Adult T-Cell Leukemia/Lymphoma: A Multicenter Clinicopathologic Experience and New Prognostic Score." Blood 112, no. 11 (November 16, 2008): 1784. http://dx.doi.org/10.1182/blood.v112.11.1784.1784.
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Abstract Purpose: Adult T-Cell Leukemia/Lymphoma (ATLL) is a rare aggressive Human T-cell Lymphotropic Virus Type-I (HTLV-I) associated peripheral T-cell neoplasm with 4 recognized clinicopathologic subtypes: acute, lymphomatous, chronic, and smoldering. Since the initial description of these variants, several studies have sought to identify additional prognostic factors. We assessed prognostic models already in use for aggressive non-Hodgkin lymphomas to develop a novel risk stratification scheme. Methods: Data regarding patients with ATLL were collected from 3 medical centers between 8/92 and 5/07. Descriptive statistics were used to assess categorical and continuous variables. Overall survival (OS) was defined as time from diagnosis to death. Survival curves for OS were estimated using the Kaplan-Meier method. Univariate associations between individual clinical factors and OS were evaluated using the log-rank test for categorical variables and the Cox model for continuous variables. Maximum logrank analysis was used to select the optimal cut-off for calcium. In order to develop a simple risk model and allow for interactions of factors independently associated with OS, we used recursive partitioning analysis. Results: 89 patients with ATLL were identified; 37 males (41.6%) and 52 females (58.4%) and median age 50 years (range 22 to 82). The acute subtype of ATLL predominated (68.5%), followed by lymphomatous (20.2%), chronic (6.8%) and smoldering (4.5%). Median OS for all sub-types was 24 weeks (range 0.9 to 315). According to the International Prognostic Index (IPI), 8 patients (9.1%) were classified as low risk, 11 patients (12.5 %) as low intermediate risk, 13 patients (14.8 %) as high intermediate risk, and 56 patients (63.6 %) as high risk, 1 patient could not be evaluated due to missing data. Median OS by IPI risk group was 271, 65, 31 and 16 weeks, respectively (p<0.01). The Prognostic Index for PTCL-U (PIT) could be determined in 68 patients; 10 patients (14.7 %) had a score of 0–1 (group 1), 19 patients (27.9 %) had a score of 2 (group 2), 31 patients (45.6 %) had a score of 3 (group 3), and 8 patients (11.8 %) had a score of 4 (group 4). Median OS by PIT risk group was 61.1, 28, 24, and 11.3 weeks respectively (p<0.01). A new risk model was developed using the variables of the IPI and PIT. In addition, calcium level at diagnosis was also included as it had independent prognostic value. Recursive partitioning of OS based on these variables gave a tree with 5 nodes, which fell into three risk categories: low risk patients with Stage I–II disease and a performance status <2; the medium risk group composed of two sets of patients: those with Stage III–IV disease with an ECOG performance status < 2 or those with an ECOG performance status ≥ 2 with calcium ≤ 11 mg/dL and age ≤ 60; and the high risk group (also comprising 2 sets of patients): those with a performance status ≥ 2 with calcium ≤ 11 mg/dL and age > 60 or those with a performance status ≥ 2 and calcium > 11 mg/dL. There were 10 patients (11.2%) in the low risk (median survival= 156.6 weeks), 31 (34.8%) in the intermediate risk (median survival = 45.4 weeks), and 48 (53.9%) in the high risk (median survival= 13 weeks) categories (p<0.01). Conclusion: This retrospective series confirms a poor outcome for North American patients with HTLV-1 related ATLL. Although the IPI and PIT identified subsets of patients, these models had liabilities. We propose a new prognostic model based on recursive partitioning analysis that successfully identifies three prognostic categories based on performance status, stage, age and calcium level at diagnosis in a more robust and distinct fashion. Table 1. Comparison of Prognostic Scores and Kaplan Meier Survival Estimates (%) of patients with ATLL International Prognostic Index (IPI) (n = 88) Prognostic Index for PTCL-U (PIT) (n = 68) ATLL Prognostic Score (APS) (n= 89) Time (wks) Low n= 8 Low-Intermed n= 11 High-Intermed n= 13 High n= 56 Group 1 n= 10 Group 2 n= 19 Group 3 N= 31 Group 4 n= 8 Low n= 10 Intermed n= 31 High n= 48 13 8 (100%) 10 (100%) 9 (75.5%) 31 (53.1%) 10 (100%) 13 (68.4%) 19 (66.3%) 3 (25.0%) 9 (100%) 27 (87.1%) 23 (46.4%) 26 8 (100%) 9 (90.0%) 6 (56.6%) 17 (31.1%) 10 (100%) 9 (51.3%) 13 (45.4%) 0 (0%) 9 (100%) 23 (77.0%) 9 (19.9%) 52 6 (75.0%) 6 (60.0%) 3 (28.3%) 9 (17.6%) 5 (50%) 5 (28.5%) 8 (30.7%) 0 (0%) 8 (88.9%) 13 (46.0%) 4 (8.8%) 78 5 (75.0%) 4 (40.0%) 2 (18.9%) 2 (4.0%) 4 (40%) 3 (17.1%) 2 (7.7%) 0 (0%) 7 (88.9%) 7 (24.8%) 0 (0%) 104 3 (56.2%) 3 (30.0%) 2 (18.9%) 2 (2.0%) 2 (30%) 3 (17.1%) 2 (3.8%) 0 (0%) 4 (61.0%) 6 (17.7%) 0 (0%) Median OS (wks) 271 65 31 16 61.1 28 24 11.3 156.6 45.4 13
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Foran, James M., Zhuoxin Sun, David F. Claxton, Hillard M. Lazarus, Mary L. Thomas, Ari Melnick, Ross L. Levine, et al. "North American Leukemia, Intergroup Phase III Randomized Trial of Single Agent Clofarabine As Induction and Post-Remission Therapy, and Decitabine As Maintenance Therapy in Newly-Diagnosed Acute Myeloid Leukemia in Older Adults (Age ≥60 Years): A Trial of the ECOG-ACRIN Cancer Research Group (E2906)." Blood 126, no. 23 (December 3, 2015): 217. http://dx.doi.org/10.1182/blood.v126.23.217.217.
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Abstract Background: Induction therapy with daunorubicin (Dauno) & cytarabine (Ara-C) [DA] has been the standard of care for eligible older adults (age ≥ 60 years) with newly diagnosed acute myeloid leukemia (AML) for over 2 decades. Single agent Clofarabine (CLO) induction & consolidation (Consol.) therapy has demonstrated important clinical activity in this age group in large phase II studies. Lower induction mortality (IM) & similar reported complete remission rate (CR) & overall survival (OS), as well as notable activity in those with higher risk disease features [including unfavorable cytogenetics, therapy-related AML (t-AML) & prior antecedent hematologic disorder (AHD)] raises the possibility that a non-Ara-C-based regimen could achieve similar or superior OS with lower toxicity. Methods: We performed a randomized United States Intergroup Phase III trial of single agent CLO [30mg/m2 x 5 days induction; 20 mg/m2 re-induction (if indicated) & 2 cycles Consol.] vs. standard DA therapy [Dauno 60mg/m2 D1-3 & Ara-C 100mg/m2 D1-7 induction x 1-2 cycles; 2 cycles Consol. with Ara-C (1.5g/m2 Q12hrs D1-6 age 60-69; once daily if age 70+)] in patients (pts) age ≥ 60 yrs with newly diagnosed AML. Patients with serum creatinine >1.0 (or GFR <60 mL/min) and those with AML-M3 and ECOG performance status >3 (PS>2 if age 70+ yrs) were excluded. Randomization was stratified by age (60-69 vs. 70+), t-AML, & AHD. Pts with HLA-matched donor were eligible for allogeneic transplantation (AlloHCT) after induction, and those completing Consol. were eligible for randomization #2 (R#2) to maintenance decitabine [20mg/m2 x 3D, monthly x 1 year] versus observation. With a target accrual of 747, E2906 was powered to determine non-inferiority [and possible superiority] of CLO vs. standard DA, and primary endpoint was OS. A weighted statistical analysis was performed to account for confounding impact of R#2. AlloHCT patients were censored at transplant in this analysis. Responses & cytogenetics were confirmed centrally and OS & CR rates were monitored by an independent Data Safety Monitoring Committee (DSMC) at pre-specified time points. Results: As of Feb 23, 2015, 727 pts were randomized. Median age was 68 years (range 60-86); 57% were male, and 38% were age ≥70 yrs. Treatment arms are well balanced for all baselineclinical & AML characteristics, & 30% had unfavorable cytogenetics. Of 659 with complete treatment information reported, 30.4% on DA vs. 40.1% on CLO received 2 cycles of induction (p=0.006). Median follow-up of surviving patients is 7.6 months. Table 1. shows early treatment results (CR, toxicity) for the 686 pts randomized as of Dec 23, 2014 (2 months prior to study end, & excluding 90 with ongoing response evaluation). DA CLO p-value CR/CRi 43.8% 42.8% p=0.87 30-day mortality 8.5% 7.9% p=0.89 60-day mortality 14.9% 13.1% p=0.58 Gr 4-5 Non-Heme Tox.Induction 27% 19% p=0.02 Gr 4-5 Non-Heme Tox.Consol. 20% 7% p=0.001 374 pts have died (174, DA; 200, CLO) & significantly inferior OS was observed for CLO vs. DA [Hazard Ratio (HR) 1.41 (95% CI 1.12-1.78)] (Fig. 1). Planned subgroup analyses were performed (Table 2) demonstrating significant differences in OS after CLO for patients age 60-69 yrs, without AHD, & with intermediate risk cytogenetics; but not for those with Unfav. Cytogen. (Fig. 2) or t-AML. Based on the primary weighted analysis, DSMC recommended suspension of new accrual to E2906 on Feb 23, 2015 & all active patients on CLO were transitioned to DA Arm. Table 2.NHR CLO/Standard (95% CI)*Weighted OS7271.41 (1.12-1.78)Unweighted OS7271.23 (1.00-1.50)Age 60-694491.48 (1.10-1.99)Age 70+2781.34 (0.93-1.93)Intermed. Risk Cytogen.3781.77 (1.27-2.47)Unfav. Risk Cytogen.2160.96 (0.65-1.43)No AHD6041.46 (1.13-1.89)AHD1231.22 (0.74-2.00)De novo AML6271.52 (1.18-1.96)Therapy-related AML1000.94 (0.54-1.61) Conclusions: Despite similar CR & IM, OS after single agent CLO is inferior to standard DA therapy for pts age ≥60 years with newly diagnosed AML who are fit for intensive therapy, and DA remains the standard of care. However no difference in OS was observed after CLO in some pre-specified high risk AML subgroups. R#2 & AlloHCT arms continue in E2906 for pts already enrolled. Embedded prospective minimal residual disease study at CR is being performed to identify pts at higher risk after CLO & DA. Figure 1. Weighted Kaplan-Meier Curves for OS Figure 1. Weighted Kaplan-Meier Curves for OS Figure 2. Unfavorable Cytogenetics OS by Therapy Figure 2. Unfavorable Cytogenetics OS by Therapy Disclosures Off Label Use: Use of clofarabine in AML, and maintenance therapy with decitabine in AML. Claxton:Medimmune: Research Funding; BMS: Consultancy; Astellas: Research Funding; Cyclacel: Research Funding; Merck: Research Funding; Ambit: Research Funding. Levine:Loxo Oncology: Membership on an entity's Board of Directors or advisory committees; CTI BioPharma: Membership on an entity's Board of Directors or advisory committees; Foundation Medicine: Consultancy. Altman:Seattle Genetics: Consultancy; BMS: Consultancy; Spectrum: Consultancy; Astellas: Consultancy; Ariad: Consultancy; Novartis: Consultancy. Al-Kali:Novartis: Research Funding.
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Boric, Dusan, and Vesna Dimitrijevic. "Absolute chronology and stratigraphy of Lepenski Vir." Starinar, no. 57 (2007): 9–55. http://dx.doi.org/10.2298/sta0757009b.
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In the last decade, a number of specialist analyses were made on the material from old excavations of Mesolithic-Neolithic sites in the Danube Gorges. These new results altered significantly our understanding of the Lepenski Vir culture. The question of chronology of this regional phenomenon has been acute since the discovery of Lepenski Vir in the 1960s, and it remains of key importance for understanding the character of Mesolithic-Neolithic transformations in this and the neighbouring regions. The most heated debate was fuelled by the initial stratigraphic and chronological attribution of the type-site itself. There remained the question about the adequate dating of the most prominent phase at this site characterized by buildings with trapezoidal bases covered with limestone floors and with rectangular stone-lined hearths placed in the centre of these features. There have been suggestions that these features also contain Early Neolithic Starcevo type pottery and other similar items of material culture and should thus be dated to the Early Neolithic historical context. Moreover, the first series of conventional radiocarbon determinations (21 dates) also suggested that the absolute chronology of these features should be confined to the period from around 6400-5500 cal BC (Fig. 1). Due to the importance of defining more precisely the chronology for the start of construction of these particular features at Lepenski Vir and for establishing the life-span of these buildings and their associated material culture, we have AMS (Accelerator Mass Spectrometry) dated a number of contexts from this site. The results are presented in this paper. The project was made possible through the Oxford Radiocarbon Accelerate Dating Service (ORADS) programme funded by the Arts and Humanities Research Council (AHRC) and the Natural Environment Research Council (NERC) of the Great Britain. Apart from those dates presented in this paper, there are 29 previously published radiometric dates from Lepenski Vir 21 made by the conventional 14C dating of charcoal and 8 AMS dates made on animal (3 dates) and human bones (5 dates). There is also a series of 20 new AMS dates made on human bones from Lepenski Vir. The last group of dates has not been published with all the contextual details and are of limited use in our analyses of absolute chronology and stratigraphy of Lepenski Vir. New dates are listed in Table 1. From 32 dated contexts from Lepenski Vir, 27 contexts are stratigraphically related to trapezoidal buildings while 5 dates are connected with the area outside of buildings. From those contexts related to trapezoidal structures, 24 contexts are dated with animal and 3 with human bones. The emphasis on the dating of animal bones is connected with problems of precision when dating samples made on human and dog bones due to the reservoir effect and the deposition of 'old' carbon. Dated remains of animal and human bones originate from the following types of stratigraphic contexts a) beneath building floors, i.e. stratigraphically the oldest contexts in the settlement (2 dates) (Fig. 2); b) between two superposed floors of trapezoidal buildings as 'sealed' contexts (8 dates) (Fig. 3); c) lying directly on top of the floors of trapezoidal buildings but not overlapped by a later floor (17 dates) (Fig. 3); d) outside of trapezoidal buildings, found in contexts such as pits, domed ovens, and burials, or in contexts that can be attributed to the occupation layer only (6 dates) (Fig. 4). The new dates indicate a very long duration of the Mesolithic period, from around 9400 to around 7500 cal BC (Fig. 2, 23). These early dates are concentrated in two particular periods that may point to two separate phases within these two millennia, with settlement discontinuities. It remains possible that there were many more occupation episodes that these dates do not encompass, and more AMS dates may indicate whether these two groupings with three dates per grouping are meaningful and representative of two separate and defined phases of occupation at this locale. This early period would correspond with the phase that the excavator of Lepenski Vir defined as Proto-Lepenski Vir although his ideas about the spatial distribution of this phase, its interpretation, duration and relation to the later phase of trapezoidal buildings must be revised in the light of new AMS dates and other available data. The phase with trapezoidal buildings most likely starts only around 6200 cal BC and most of the trapezoidal buildings might have been abandoned by around 5900 cal BC. The absolute span of only two or three hundred years and likely even less, for the flourishing of building activity related to trapezoidal structures at Lepenski Vir significantly compresses Srejovic's phase I. Thus, it is difficult to maintain the excavator's five subphases which, similarly to Ivana Radovanovic's more recent re-phasing of Lepenski Vir into I-1-3, remain largely guess works before more extensive and systematic dating of each building is accomplished along with statistical modeling in order to narrow the magnitude of error. On the whole, new dates from these contexts better correspond with Srejovic's stratigraphic logic of sequencing buildings to particular phases on the basis of their superimposing and cutting than with Radovanovic's stylistic logic, i.e. her typology of hearth forms, ash-places, entrance platforms, and presence/absence of -supports around rectangular hearths used as reliable chronological indicators. The short chronological span for phase I also suggests that phase Lepenski Vir II is not realistic. This has already been shown by overlapping plans of the phase I buildings and stone outlines that the excavator of the site attributed to Lepenski Vir II phase. According to Srejovic, Lepenski Vir phase II was characterized by buildings with stone walls made in the shape of trapezes, repeating the outline of supposedly earlier limestone floors of his phase I. However, the trapezoidal buildings must be envisioned as dug-in features with their rear, narrow side dug deep into the slope since these features were dug into the sloping terrace where the site is situated. It is more likely that these stone constructions assigned to a separate phase were part of the same trapezoidal buildings with limestone floors assigned by the excavator to phase I. Thus, vertical stone walls existed on the level above limestone floors, built in dry wall technique around buildings' floors and cuts. The visual overlap of phases I and II clearly shows the match between these stone constructions and trapezoidal limestone floors (Fig. 27). Even on the published section of the western part of the settlement of Lepenski Vir which runs through the backs of Houses 43, 34, 27, 20, 33 and 32, phase II is not marked (see Fig. 28), which might lend further support to our conclusion about its elusive character. Furthermore, no activity areas were reported with regard to the 'floor' level of these structures, with the exception of the largest building at the site, XLIV. Therefore, trapezoidal stone walls previously attributed to phase II were part of the same phase I buildings. Henceforth we suggest treating Srejovic's phases I and II as a single phase and we refer to this building horizon as Lepenski Vir I-II (see Table 2). The new dating programme also suggests no temporal break between phases Lepenski Vir I-II and phase III. The dates indicate that Srejovic was right to separate the latter as it seems that most of the trapezoidal buildings were abandoned by 5900 cal BC and that new and different occupation pattern commenced at the site in the period following 5900 cal BC. Yet, some of the dates indicate that, at the current resolution of the chronological scale there could have been some overlapping between the use of particular trapezoidal buildings, perhaps primarily for the interment of human burials (e.g. House 21 and Burials 7/I and II, see Fig. 11), and the new types of contexts that appear around 5900 cal BC. These new contexts included a number of pits, dug primarily in the rear area of the site, outside of the zone with trapezoidal buildings. There are also several domed ovens the function of which remains unclear. Also, crouched inhumations became the dominant burial rite (of possibly migrant individuals) during this phase. Some of these crouched burials were found lying on the floors of trapezoidal buildings. This seems to have been the time of significant changes in patterns of habitation of the Lepenski Vir community. Bones of domestic animals were also found in those features assigned to phase III. We have directly dated four samples that come from domestic animals (sheep/goat, cattle and pig) found in these contexts at Lepenski Vir. In this way, it was possible to directly date the introduction of domestic animals to the site. The results suggest that the these domestic animals must have been introduced to Lepenski Vir in the post-5900 cal BC period. The upper limit of this Middle Neolithic phase Lepenski Vir III remains to be elucidated further. While previous charcoal dates indicated that the site was used up until around 5400 cal BC, the upper limit of new dates is around 5700 cal BC. Existing dates from the neighbouring site of Padina suggest that some trapezoidal buildings at that site (Houses 15 and 18) might have been used up until 5500 cal BC. It is possible that future dates will move this limit to the end of the Middle Neolithic, i.e. c. 5500 cal BC. At this time, previously occupied sites on the Danube, such as Lepenski Vir, Padina, Vlasac, etc., were abandoned for more than a millennium. Lepenski Vir is used again during the Eneolithic period, when a burial of the Salku?a culture, AMS dated to around 4300 cal BC, was interred here (see Burial 2, Fig. 25). New radiometric dates from Lepenski Vir, together with all other newly available data, demand a revision of conclusions previously made with regard to the absolute chronology of particular phases as well as stratigraphic attribution of certain contexts. Such a revision inevitably leads us to suggest a new stratigraphic division and phasing of Lepenski Vir (see Table 2). This revised phasing largely keeps the old nomenclature of the excavator of Lepenski Vir. We would like to avoid confusions and complications in suggesting completely new labels for particular phases when there is no need for such a radical break from the original understanding of the site's stratigraphy. We are aware that the future dating of Lepenski Vir may affect certain elements of our conclusions and that the suggested changes thus remain tentative. Yet, at present, our conclusions are firmly grounded in the available data.
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Morbeck, Elizabeth, Alexsandro Oliveira, Elkimen Noêmia, Kátia Ferreira Costa Campos, and Keli Bahia Felicíssimo Zocratto. "Gerenciamento distrital e local do Protocolo de Toxoplasmose Congênita em Venda Nova: Pet GraduaSUS do Curso Gestão de Serviços de Saúde." JMPHC | Journal of Management & Primary Health Care | ISSN 2179-6750 8, no. 3 (September 19, 2018): 68–69. http://dx.doi.org/10.14295/jmphc.v8i3.667.
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Introdução: A Política Nacional de Educação Permanente, instituída pela portaria GM/MS 1.996/2007, foram validados todos os princípios da educação permanente. Uma de suas estratégias é a aprendizagem pela construção de novos significados para os processos de trabalho com ações educacionais de trabalhadores em saúde fundamentadas no respeito às particularidades loco-regionais, na lógica das necessidades de forma ascendente e coletiva, contemplando prioridades da gestão no monitoramento dos processos de aprimoramento e formação profissional. Em Belo Horizonte, a base territorial foi dividida em nove Distritos Sanitários, correspondendo às áreas administrativas da Prefeitura. No contexto descentralizado das políticas públicas, o nível de gestão regional conecta-se com os formuladores da gestão municipal e com seus executores no nível local. As sedes distritais são responsáveis diretos pela implementação, acompanhamento e avaliação da Atenção Primária à Saúde (APS), formada pelas áreas de abrangência dos Centros de Saúde (C.S.). Esta integração hierárquica dos níveis, central, distritais e locais, estabelece a estrutura organizacional da gestão do cuidado em saúde do município. Para enfrentar os desafios é necessário o desenvolvimento de competências e habilidades de gestão capazes de integrar diferentes saberes e tecnologias. Considera-se que a integração ensino-serviço é uma estratégia que pode proporcionar o desenvolvimento do aluno, e nesse sentido, o Programa de Educação pelo Trabalho em Saúde (PET Saúde), lançado em 2008, tem proporcionado aprendizado aos profissionais de saúde e acadêmicos, na forma de vivências, que contemplam as necessidades do SUS de educação pelo trabalho. O Programa se desenvolve por meio de integração interdisciplinar, parceria da Secretaria Municipal de Saúde (SMSA) de Belo Horizonte e a Universidade Federal de Minas Gerais (UFMG). As atividades de aprendizagem são coordenadas por tutores (professores universitários) que, em articulação com os preceptores (profissionais de áreas da rede municipal de saúde) e alunos de graduação. Objetivo: Qualificar os processos de integração ensino/serviço/comunidade a partir de um olhar específico da gestão sobre os indicadores Materno Infantil nos serviços da APS. Métodos: Trata-se de um relato de experiência da proposta desenvolvida pelo PETGraduaSUS do Curso de Gestão de Serviços de Saúde/UFMG desde maio de 2016 com previsão de término em fevereiro de 2018. A escolha da metodologia baseou-se no entendimento de que a mesma é capaz de propiciar e enaltecer a rotina dos serviços em saúde, possibilitando uma maior compreensão e construção de um pensamento lógico de resolutividade voltado para a gestão. Para o desenvolvimento dos projetos este estudo, utilizou-se a metodologia participativa como ferramenta que implica na coparticipação de diferentes atores sociais envolvidos no processo. Apresenta a perspectiva de conhecer o contexto no qual os atores se encontram inseridos, vinculados às situações que necessitam de intervenção. Na busca de alternativas, a reflexão e a ação, vinculadas a participação ativa dos sujeitos envolvidos produz ênfase na valorização do saber local que interage com o saber científico. As ações estabelecidas junto ao serviço estiveram vinculadas ao ciclo de vida Materno-Infantil do município de Belo Horizonte, e foram delineadas a partir de diagnósticos situacionais com posterior desenvolvimento de projetos de intervenção em cada campo estabelecido. Resultados: No Distrito de Venda Nova, além do levantamento dos indicadores materno-infantil, a toxoplasmose foi escolhida como tema de atuação, por assumir a maior relevância no período gestacional. A Toxoplasmose é uma infecção parasitária causada por um protozoário, o Toxoplasma gondii; cujo reservatório natural é o gato. O homem é acidentalmente infectado, e a doença é adquirida pela ingestão de alimentos contendo cistos de Toxoplasma. Outra forma é pelas fezes de gatos, que eliminam grande quantidade de oocistos durante a infecção aguda. A infecção ocorre quando o parasita atinge o concepto por via transplacentária e a transmissão fetal acontece quando a mãe adquire-a durante a gestação. Assim, a infecção congênita não ocorre em mães que já tiveram infecção prévia, exceto quando ocorrer reativação por alguma forma de imunodepressão. O parasita se multiplica na placenta e ao ser transmitido para o feto pode causar lesões na retina e sistema nervoso central. As gestantes numa situação de primoinfecção, geralmente são assintomáticas e somente identificadas por exames sorológicos solicitados no acompanhamento do pré-natal. O tratamento é realizado no pré-natal, além da investigação das crianças suspeitas, após o nascimento. Os exames são realizados nos C.S. pela punção digital num papel filtro e, facilmente, transportados para o laboratório responsável pela análise, o Núcleo de Ações e Pesquisa em Apoio Diagnóstico da UFMG (NUPAD-UFMG). Os testes diagnósticos apresentam maior especificidade quando realizados até a 12ª semana de gestação, realçando a importância de se iniciar o pré-natal logo no início da gravidez. A indicação é que esse teste deve ser repetido durante o acompanhamento, caso a gestante seja suscetível, isto é, apresente testes sorológicos (IgG e IgM) negativos. Os integrantes alocados na equipe PET - Venda Nova com o propósito de contribuir para o enriquecimento do processo de aprendizagem, optaram pelo estudo de caso como estratégia de investigação. O projeto aconteceu em fases, que foram distribuídas da seguinte forma: Fase I (Observacional) que consiste na inserção dos alunos nas UBS, com o objetivo de adquirirem vivências da organização da APS nos C.S., bem como os elementos que compõem sua estrutura, seus métodos gerenciais e suas práticas profissionais para a gestão e capacitação de pessoas.Por meio desta vivência, além de serem contextualizados e sensibilizados para compreender os processos realizados nos C.S, os alunos do curso de Gestão em Serviços de Saúde criaram um portfólio contendo registros textuais e não textuais da realidade encontrada, a fim de obterem minúcias sobre as características do espaço, seus processos de trabalho, estabelecimento de rotinas, entre outros. Na fase II ocorreram as Coletas e Tabulações vinculados à Toxoplasmose que consiste no acompanhamento de primeiras e segundas consultas de pré-natal realizadas pelas equipes, nas quais acontecem as abordagens dos profissionais com a gestante, a respeito da Toxoplasmose Congênita. Nesta fase, os alunos tabularam os dados em relação ao processo da consulta, com ênfase no protocolo, com auxílio da elaboração de gráficos e tabelas, fazendo posteriormente uma análise descritiva. Para o acompanhamento das demais consultas, os alunos recolheram dados no SIS Rede – SMS-BH, dos indicadores do Distrito de Venda Nova e no portal NUPAD - Triagem Pré-Natal. A fase III consiste no rastreamento do exame, a fim de detectar possíveis erros de administração do protocolo na saída e chegada do mesmo no CS e na esfera distrital. A fase IV aborda a elaboração de uma estratégia de melhoria dos índices materno-infantil de cunho gerencial, baseado na experiência vivenciada. Estas estratégias pensadas serão apresentadas formalmente para as gerências de cada unidade, que poderá utilizá-las como ferramentas para correção do problema. A fase V é a avaliação das medidas adotadas pelas gerências locais através da ferramenta de qualidade Ciclo PDCA e discussão com as gerências locais. Conclusões: Ações desenvolvidas apresentam foco na interdisciplinaridade e interprofissionalidade, na integração ensino/serviço/comunidade, na humanização do cuidado, na integralidade da assistência, no desenvolvimento das atividades que considerem a diversificação de cenários de práticas e redes colaborativas na formação para o SUS. O Pet Gradua SUS do Curso de Gestão de Serviços de Saúde, buscou identificar nas propostas de intervenção uma formação diferenciada para o trabalho no SUS, fortalecido pela prática e EPS.
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Wojtaszak, Andrzej. "Kształtowanie relacji polsko-niemieckich na pograniczu na przykładzie powiatu polickiego." Pogranicze. Polish Borderlands Studies 7, no. 3 (December 20, 2019). http://dx.doi.org/10.25167/ppbs1267.
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Wzajemne relacje polsko-niemieckie po 1990 r. ulegały trwałym przemianom. Stopniowo przystąpiono do budowania dobrosąsiedzkich stosunków w wymiarze transgranicznym. Celem prezentowanego artykułu jest przedstawienie aktywności instytucji z obszaru powiatu polickiego w kształtowaniu dobrych stosunków z sąsiednimi obszarami pogranicza po stronie niemieckiej. Relacje przybierały głównie wymiar kulturalny, turystyczny, oświatowy, dotyczyły także łączenia infrastruktury drogowej i wspólnych działań na rzecz bezpieczeństwa lokalnego i ekologii. Możemy przyjąć, że taka współpraca przyczynia się do lepszego wzajemnego zrozumienia oraz wypracowania wspólnych projektów i określenia możliwych wzajemnych oczekiwań. Pogranicze polsko-niemieckie na tym obszarze charakteryzuje także wzrost osadnictwa polskiego w niemieckich gminach pogranicznych, czemu towarzyszy udział Polaków zamieszkujących na obszarze Niemiec w lokalnych wyborach samorządowych. Ważnymi elementami sprzyjającymi aktywizacji działań na pograniczu są m.in. programy pomocowe UE, np. INTERREG III (2000-2006), INTERREG IV (2007-2013), INTERREG V (2014-2020) objęte koncepcją Europejskiej Współpracy Terytorialnej (Europejski Fundusz Rozwoju Regionalnego). Tworzone wspólne programy i przedsięwzięcia sprzyjają ponadgranicznej integracji i zbliżeniu społeczeństw, oraz zmianie wzajemnych ocen i przełamywaniu stereotypów.
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Van der Zanden, B., A. Kuijpers, D. Philippsen, and T. Houben. "Präventionsstrukturen und -konzepte in der Euregio Maas-Rhein Interreg III-Projekt: Risikoverhalten Jugendlicher." Das Gesundheitswesen 66, no. 08/09 (September 21, 2004). http://dx.doi.org/10.1055/s-2004-833844.
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Gunnarsson, Björn, Hildigunnur Svavarsdóttir, Sveinbjörn Dúason, Andrew Sim, Agnes Munro, Cathy McInnes, Roddy MacDonald, Karl-Axel Ängquist, and Britt-Marie Nordström. "Ambulance Transport and Services in the Rural Areas of Iceland, Scotland and Sweden." Australasian Journal of Paramedicine 5, no. 1 (July 16, 2015). http://dx.doi.org/10.33151/ajp.5.1.402.
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Introduction The University Hospital in Akureyri (Centre for Emergency Medical Service (EMS) Education) in Iceland, Emergency & Disaster Medical Centre (AKMC) in Sweden and National Health Service - Western Isles in Scotland have undertaken a project “Ambulance Transport and Services in the Rural Areas” (ATSRuAr); the object of this paper is to provide an overview of the present status of ambulance transport and services in the three participating regions. This is a project of the INTERREG III Northern Periphery Programme (NPP) who provided a grant for the work. Methods Each partner reviewed the current status of prehospital services in their country or region and presented the results at a project meeting in Iceland in March 2006. Results & Conclusion Geography and weather provide a challenge to the ambulance transport and services in sparsely populated northern rural areas. The Emergency Medical Services (EMS) systems in these three northern rural areas have many similarities. However, there are differences in the number and distribution of ambulances, the running of the service, education and training of ambulance personnel and first responder schemes. This collaboration will debate on the provision of ambulance transport. Research is needed to indicate how improvements in ambulance transport can improve patient outcome in rural areas.
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Tiberti, Rocco, Rossana Caroni, Massimiliano Cannata, Andrea Lami, Dario Manca, Daniele Strigaro, and Michela Rogora. "Automated high frequency monitoring of Lake Maggiore through in situ sensors: system design, field test and data quality control." Journal of Limnology 80, no. 2 (June 21, 2021). http://dx.doi.org/10.4081/jlimnol.2021.2011.
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A high frequency monitoring (HFM) system for the deep subalpine lakes Maggiore, Lugano and Como is under development within the EU INTERREG project SIMILE. The HFM system is designed to i) describe often neglected but potentially relevant processes occurring on short time scale; ii) become a cost-effective source of environmental data; and iii) strengthen the coordinated management of water resources in the subalpine lake district. In this project framework, a first HFM station (LM1) consisting of a monitoring buoy was placed in Lake Maggiore. LM1 represents a pilot experience within the project, aimed at providing the practical know-how needed for the development of the whole HFM system. To increase replicability and transferability, LM1 was developed in-house, and conceived as a low-cost modular system. LM1 is presently equipped with solar panels, a weather station, and sensors for water temperature, pH, dissolved oxygen, conductivity, and chlorophyll-a. In this study, we describe the main features of LM1 (hardware and software) and the adopted Quality Assurance/Quality Control (QA/QC) procedures. To this end, we provide examples from a test period, i.e., the first 9-months of functioning of LM1. A description of the software selected as data management software for the HFM system (IstSOS) is also provided. Data gathered during the study period provided clear evidence that coupling HFM and discrete sampling for QA/QC controls is necessary to produce accurate data and to detect and correct errors, mainly because of sensor fouling and calibration drift. These results also provide essential information to develop further the HFM system and shared protocols adapted to the local environmental (i.e., large subalpine lakes) and technical (expertise availability) context. Next challenge is making HFM not only a source of previously unaffordable information, but also a cost-effective tool for environmental monitoring.
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Raja, Khuram, Kirsty Hickson, Andrew Treweeke, Gordon Rushworth, Emma Morrison, Euan Sandilands, James Cobley, David McEneaney, Michael Eddleston, and Ian Megson. "P0917N-ACETYL CYSTEINE FAILS TO IMPACT ON PLASMA ANTIOXIDANT CAPACITY IN BOTH A PLACEBO CONTROLLED CROSSOVER STUDY AND A PARALLEL GROUP TRIAL OF PATIENTS WITH CKD STAGE III: IMPLICATIONS FOR ITS USE AS A PROPHYLACTIC FOR CONTRAST INDUCED NEPHROPATHY." Nephrology Dialysis Transplantation 35, Supplement_3 (June 1, 2020). http://dx.doi.org/10.1093/ndt/gfaa142.p0917.
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Abstract This project has been funded by the EU’s INTERREG VA programme, managed by the special EU Programmes Body (SEUPB) Background and Aims N-acetyl-L-cysteine (NAC) has been proposed as a prophylactic for the prevention of contrast induced nephropathy (CIN), a serious, adverse complication following administration of contrast media in patients with diabetes and chronic kidney disease (CKD). However, clinical trial results have failed to demonstrate consistently the beneficial qualities of NAC in this setting. The suggested mechanism by which NAC has been proposed to be effective is via antioxidant activity, but NAC itself appears not to be a powerful antioxidant; intracellular conversion of NAC to glutathione (GSH) is essential for antioxidant effects. We tested the hypothesis that oral or intravenous NAC fails to increase antioxidant activity in the plasma of healthy volunteers or CKD stage III patients undergoing elective coronary angiography. Method 16 healthy volunteers (8 receiving contrast media) and 8 patients with chronic renal failure were recruited to 3 separate groups as a part of a crossover design study. 66 patients with CKD stage III undergoing elective coronary angiography were recruited to a parallel group randomized controlled trial. Each volunteer or patient was randomised to receive NAC (i.v.; 50 mg/kg/hr infusion for 2 h, followed by 20 mg/kg/hr infusion for a further 5 h), or NAC (oral; 1200 mg twice daily, commencing the day before the study visit) or placebo. Participants attended the Clinical Research Facility on three occasions for the crossover groups, but only once in the parallel group trial. Patients were infused with para-aminohippurate (PAH) and inulin to enable measurement of renal function parameters. Plasma and paired buffy coat samples were collected at several time points for 2 hours before contrast infusion and for 6 hours after. Samples were used to measure various clinical parameters, along with intracellular and plasma thiol concentrations and the plasma antioxidant capacity (oxygen radical antioxidant capacity; ORAC). Results Plasma NAC concentrations peaked at 222 µM (healthy volunteers), 354 µM (CKD patients), 271 µM (healthy volunteers receiving contrast) and 348 µM (CKD patients undergoing elective coronary angiography) following infusion of NAC. The corresponding peak concentrations were ∼2 µM following oral NAC across all groups. No comparable increase in the plasma compartment ORAC antioxidant capacity was measured in any of the treatment groups. Equally, contrast infusion itself did not significantly reduce antioxidant capacity in plasma, even in the placebo group. Buffy coat measures showed that there was a significant increase of intracellular GSH in some patients. Also, no clear additional benefit was witnessed by increasing plasma NAC ∼100-fold through infusion of NAC over oral administration. Conclusion NAC fails to influence ORAC antioxidant capacity in the plasma compartment of CKD stage III patients receiving contrast media. Our results question the importance of oxidative stress in contrast-induced nephropathy. Furthermore, the findings fail to demonstrate a direct antioxidant impact of NAC in the plasma compartment and question the antioxidant hypothesis related to contrast-induced nephropathy and NAC.
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Hölscher, Luise, and Johannes Rosenthal. "Leistungsmessung der Internen Revision – Teil III: Leistungsmessung mittels Transaktionskosten." Zeitschrift Interne Revision, no. 2 (April 1, 2009). http://dx.doi.org/10.37307/j.1868-7814.2009.02.04.
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Hahn, Ulrich. "CBOK: Ergebnisse einer weltweiten Erhebung des IIA zu Stand und Entwicklung der Internen Revision." Zeitschrift Interne Revision, no. 1 (February 1, 2008). http://dx.doi.org/10.37307/j.1868-7814.2008.01.06.
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Santos, Mari Aparecida dos, Antonio Carlos Moretto, Rossana Lott Rodrigues, and Ricardo Kureski. "Escolaridade, emprego e renda: o setor educação mercantil no Paraná em 2006." Revista Economia & Tecnologia 7, no. 1 (March 30, 2011). http://dx.doi.org/10.5380/ret.v7i1.26850.
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A educação é capaz de proporcionar melhorias significativas ao ambiente social e econômico uma vez que, no longo prazo, é meio para o desenvolvimento da capacitação do fator trabalho e, no curto prazo, como setor econômico, interage com outros setores da economia demandando e ofertando bens e serviços. Com enfoque no curto prazo, este estudo objetiva dimensionar a importância econômica do setor educação mercantil no Paraná, em 2006, em termos de emprego e renda. Por meio da Matriz Insumo-Produto (MIP) em conjunto com as informações da Pesquisa Nacional por Amostra de Domicílios (PNAD), os seguintes resultados foram obtidos: i) 58,2% dos ocupados no setor Educação Mercantil possuíam ensino superior, representando 4,8% do total de pessoas ocupadas com 12 ou mais anos de estudo no estado; ii) o trabalhador melhor remunerado tinha pós-graduação, com média salarial mensal 104% maior relativamente à dos trabalhadores com graduação e 165,8% maior com relação à média salarial dos trabalhadores com ensino médio; iii) o menor diferencial de renda média mensal entre os dois níveis intermediários de escolaridade relativamente aos demais setores da economia paranaense; e iv) dentre os demais setores, o setor educação mercantil seria o sétimo maior gerador de emprego e o segundo maior na geração de renda, no caso do aumento em um milhão de reais em sua demanda final.
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Fuentes González, Nieves, and Alejandra Fuentes Ramírez. "Meaning of Receiving Artificial Nutritional Support in People in the Postoperative Period of Abdominal Surgery." Investigación y Educación en Enfermería 38, no. 2 (July 10, 2020). http://dx.doi.org/10.17533/udea.iee.v38n2e08.
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Objective. This work sought to describe the meaningof receiving artificial nutritional support in people in thepostoperative period of abdominal surgery.
Methods.This was a qualitative study of grounded theory, followingthe guidelines by Corbin and Strauss. The informationwas collected through 26 in-depth interviews with 21participants, interned in a tier III health care hospital inthe city of Tunja, Colombia.
Results. The study describesfour categories, which account for the way in which theperson experiences physical, physiological, emotional,and social changes when receiving artificial nutritionalsupport. The categories include stopping eating andbecoming artificially fed, decreasing the ability to moveto recover movement, experiencing the difficulty of having artificial nutritional support, and reaching the disease to transform life. The dataanalysis shows that the basic surgical pathology and the artificial nutritional supportare sudden events that fragment the daily life of the person. These individualsdemand the mobilization of religious, family, and social resources to strengthen theperson’s internal and external environment and, thus, achieve the health situation.
Conclusions. The analysis of the meanings shows how the person reflects andinterprets the reality of receiving artificial nutritional support, an event that hasimplicit physical discomfort, emotional changes, and physical appearance, whichare determinants in the behavior and practice of artificial nutrition. However,artificial nutritional support becomes for the person an alternative to live and recoverthe state of health.
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"Annexe III – Traité sur l'Union européenne (extrait) modifié par le traité de Lisbonne. Troisième partie – Les politiques et actions internes de l’Union (art. 26 à 197)." Les Cahiers de l'INSEP 44, no. 1 (2009): 155. http://dx.doi.org/10.3406/insep.2009.1071.
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