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Dissertations / Theses on the topic 'Interruption of drug delivery'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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1

Trevisan, Luciano Mangueira. "Avaliação das ações judiciais para a obtenção do tratamento da fenilcetonúria no Rio Grande do Sul." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/88547.

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A Fenilcetonúria (PKU) é uma doença genética rara detectada pelo Programa Nacional de Triagem Neonatal (PNTN) por meio do "teste do pezinho". Uma vez diagnosticada e tratada precocemente com dieta específica e fórmula metabólica isenta de fenilalanina (Phe), a ocorrência de retardo mental é prevenida nestes pacientes. Mesmo sendo fornecida gratuitamente pelo Sistema Único de Saúde (SUS), mediante protocolo clínico, estima-se que os pacientes com PKU têm encontrado dificuldades de acesso à fórmula metabólica, recorrendo à via judicial para garantir a continuidade de seu tratamento. Não existem

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2

Critchley, Helen. "Intranasal drug delivery." Thesis, University of Nottingham, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236046.

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3

Irwin, Michael Garnet. "Patient maintained drug delivery." Thesis, Click to view the E-thesis via HKUTO, 2003. http://sunzi.lib.hku.hk/hkuto/record/B31981847.

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4

Dupart, Patrick S. "Drug Delivery with Light." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5691.

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Cancer is responsible for about 25% of deaths in developed countries and for 15% of all deaths worldwide. Cancer is a devastating disease and while there have been great advances in the development of anticancer drugs, off-target toxicity is a major limitation with conventional cancer chemotherapy. The consequence of this form of treatment results in the killing of healthy and rapidly-growing non-cancerous cells including cells in the bone marrow; hair follicles; and cells in the mouth, digestive tract, and reproductive system. In addition to these general effects, certain anticancer drugs can

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5

Leach, Jeffrey Harold. "Magnetic Targeted Drug Delivery." Thesis, Virginia Tech, 2003. http://hdl.handle.net/10919/31261.

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Methods of guiding magnetic particles in a controlled fashion through the arterial system in vivo using external magnetic fields are explored. Included are discussions of applications, magnetic field properties needed to allow guiding based on particle characteristics, hemodynamic forces, the uniformity of field and gradients, variable tissue characteristics, and imaging techniques employed to view these particles while in transport. These factors influence the type of magnetic guidance system that is needed for an effective drug delivery system. This thesis reviews past magnetic drug deliv

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6

Ketkar, Amol Sharad. "Polymeric drug delivery systems /." The Ohio State University, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487859879937796.

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7

Wang, Yan. "Peptide-drug conjugate for Her2-targeted drug delivery." Scholarly Commons, 2018. https://scholarlycommons.pacific.edu/uop_etds/3567.

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Recent strategies for anticancer drug design have been focused on utilizing antibody as a drug or targeted moiety for targeted drug delivery. Antibody−drug conjugates (ADCs) have become a promising new class of targeted therapeutic agents for treatment of cancer. ADCs are designed to preferentially direct a cytotoxic drug to a cell-surface antigen recognized by an antibody. However, there are some challenges in developing ADCs, such as limited solid tumor penetration, high manufacturing costs and antibody-drug stoichiometry. Smaller molecules such as peptides have been shown to specifically bi

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8

Andrews, Samantha Nacole. "Microdermabrasion for transdermal drug delivery." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37150.

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The skin serves as a semi-permeable barrier that protects the body from pathogens and water loss. The stratum corneum, the upper 10-15 µm layer of skin, is the primary barrier layer. Due to its structure, only drugs that are lipophilic and with a low molecular weight (<500 Da) can penetrate intact skin. This study examines the use of microdermabrasion as a method of removing the stratum corneum to increase the skin's permeability to hydrophilic molecules, proteins, and vaccines. Microdermabrasion is a FDA-approved cosmetic skin resurfacing procedure that removes the stratum by bombarding it wi

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9

Kipke, Sandra. "Implantierbare diffusionsgesteuerte Drug-Delivery-Systeme." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=971895406.

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10

Mazza, Mariarosa. "Peptide nanofibres for drug delivery." Thesis, University College London (University of London), 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553693.

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It is possible that peptides and proteins may be used to treat a wide range of Central Nervous System diseases if these molecules were able to cross the blood brain barrier (BBB). Currently these molecules do not cross the BBB due to their hydrophilic nature and large size. The aim of this work was to investigate the therapeutic applicability of peptide nanofibres as a new peptide brain delivery system. We hypothesise that hydrophilic peptides, when made lipophilic by attaching an acyl chain via a cleavable ester linkage, are able to cross the blood brain barrier and that the resulting lipidic

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11

Squire, Marie A. "Protein-based drug delivery systems." Thesis, University of Canterbury. Chemistry, 2004. http://hdl.handle.net/10092/6518.

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The targeted delivery of drugs is one of the most actively pursued goals in anti-HIV and anti-cancer chemotherapy. This project takes a proof-of-concept approach to the development of protein-based drug delivery systems - delivery systems that would package, target, and deliver cytotoxins to diseased cells. Primarily, this project explores the use of the potent anti-HN protein, cyanovirin-N (CV-N), to actively target and deliver cytotoxic natural products to HN-infected cells. This project also investigates the use of human serum albumin (HSA), a 66 kDa protein, as a macromolecular carrier to

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12

Deacon, Matthew. "Polymer bioadhesives for drug delivery." Thesis, University of Nottingham, 1999. http://eprints.nottingham.ac.uk/11636/.

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This study is a natural follow on from previous work by M. T. Anderson and I. Fiebrig. The goal of those latter and of the present study is to find a mucoadhesive system for improving the oral bioavailability of a number of drugs, for example bioactive peptides and proteins. This current work evaluates the adhesive properties of a cationic polymer and a cationic protein to mucus glycoproteins as a step towards the future development of a mucoadhesive drug delivery system. Four different mucin populations were analysed in solution (a freshly purified sample PGM-MD, and three purified from diffe

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13

Muldoon, B. M. "Mucoadhesive systems for drug delivery." Thesis, Queen's University Belfast, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268336.

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14

Leane, Michael. "Chitosan for oral drug delivery." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406978.

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15

Allen, Rosamund Elizabeth. "Liposomes as drug delivery systems." Thesis, University of Essex, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.352982.

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16

Dickers, Kirsten. "Drug delivery devices from polyglycolide." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415267.

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17

Zderic, Vesna. "Ultrasound-enhanced ocular drug delivery /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/8085.

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18

Hunt, Graham. "Mucoadhesive materials for drug delivery." Thesis, Cardiff University, 1988. http://www.gbv.de/dms/bs/toc/123058414.pdf.

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19

Jiang, Ninghao. "Ocular drug delivery using microneedles." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/19796.

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Thesis (Ph.D)--Chemical Engineering, Georgia Institute of Technology, 2007.<br>Committee Chair: Prausnitz, Mark R.; Committee Member: Allen, Mark; Committee Member: Edelhauser, Henry; Committee Member: Geroski, Dayle; Committee Member: Nickerson, John; Committee Member: Sambanis, Athanassios.

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20

Yohe, Stefan Thomas. "Superhydrophobic materials for drug delivery." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12898.

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Thesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Superhydrophobicity is a property of material surfaces reflecting the ability to maintain air at the solid-liquid interface when in contact with water. These surfaces have characteristically high apparent conta

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21

Lajhar, Fathi. "Electrospray for pulmonary drug delivery." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/electrospray-for-pulmonary-drug-delivery(b8aeaea9-9032-40f5-a8e0-b51c1ba8c8f8).html.

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Drug administration through the pulmonary route is an ancient technique that evolved from inhaling the smoke of certain leaves as a medicine. The optimum droplet diameter for the pulmonary system deposition has been identified to be in the range from 2 to 3.5 μm, with potential deposition rates of up to 80% of this size range. Currently, the most used aerosol generator methods are the pressurized metered dose inhalers. However, they generally exhibit low deposition efficiency with less than 20 % of the spray reaching the target area of the lungs as most of the drug deposited in the upper airwa

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22

Kim, Jung Hak. "Nanoemulsions for dermatological drug delivery." Thesis, University of Strathclyde, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501907.

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23

Meidan, Victor M. "Phonophoresis and topical drug delivery." Thesis, Aston University, 1996. http://publications.aston.ac.uk/10939/.

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In this study, investigations into phonophoresis were conducted by employing 3 distinct in vitro models. The aim of the first model was to evaluate the effect of ultrasound on the migration rate of different classes of molecules through agar gel. The derived data suggested that small, relatively hydrophobic molecules are more susceptible to ultrasound-enhanced diffusion through the water-filled channels of the agar gel. The application of heat alone increased drug migration by a similar magnitude as the ultrasound, indicating that ultrasonic heating directly increases the thermodynamic potenti

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24

Sanderson, Francis D. "Absorption models of drug delivery." Thesis, Aston University, 1986. http://publications.aston.ac.uk/12457/.

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25

Yapa, Asanka Sajini. "Nanosponges for advanced drug delivery." Diss., Kansas State University, 2017. http://hdl.handle.net/2097/35436.

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Doctor of Philosophy<br>Department of Chemistry<br>Stefan Bossmann<br>A novel type of supramolecular aggregate, named "nanosponge" was synthesized through the interaction of novel supramolecular building blocks with trigonal geometry. The cholesterol-(K/D)[subscript n]DEVDGC)₃-trimaleimide unit consists of a trigonal maleimide linker to which homopeptides (either K or D) of variable lengths (n = 5, 10, 15, 20) and a consensus sequence for executioner caspases (DEVDGC) are added via Michael addition. Upon mixing in aqueous buffer, cholesterol-(K)[subscript n]DEVDGC)₃-trimaleimides, as well as a

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26

Zaher, Amir. "Remotely controlled drug delivery systems." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/57611.

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Implantable drug delivery is becoming an increasingly important field of research, providing great potential for a wide range of flexible and low cost solutions for localized treatment of chronically debilitating diseases. This dissertation presents work that encompasses several approaches for the remote triggering, powering, and control of micro drug delivery devices and systems, designed with remote-controllability, minimal power requirements, biocompatibility, and the potential for minimally invasive implantation in mind. The control mechanisms used rely on microtechnology, nanotechnology,

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27

Barry, Peter Walter. "Problems with inhalational drug delivery." Thesis, University of Leicester, 1999. http://hdl.handle.net/2381/29591.

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Inhalational therapy is used to deliver medication to the lung, either to treat diseases or, less commonly, for systemic absorption. A number of devices have been developed to aid or improve inhalational therapy, and this thesis deals with metered dose inhalers, used with spacer devices, and nebulisers. Despite their seemingly simple construction and concept, the correct choice and use of an inhalational drug delivery device can dramatically alter the amount of drug available for inhalation. Studies in this thesis, supported by emerging pharmacokinetic evidence, have highlighted areas where th

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28

Wendel, Sebastian Oliver. "Bacteria as drug delivery vehicles." Diss., Kansas State University, 2014. http://hdl.handle.net/2097/18804.

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Doctor of Philosophy<br>Department of Chemical Engineering<br>Stefan H. Bossmann<br>Both chemotherapy for cancer treatment and antibiotic therapy for bacterial infections require systemic applications of the drug and a systemic application is always linked to a number of disadvantages. To circumvent these a targeted drug delivery system was developed. It utilizes the ability of phagocytes from the hosts own immune system to recognize and internalize antigens. Deactivated M. luteus, a non-pathogenic gram positive bacteria was loaded with high concentrations (exceeding the IC50 at least 60 fold

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29

Birudaraj, Kondamraj. "Transbuccal drug delivery: In vitro characterization of transport pathway of buspirone and bioadhesive drug delivery system." Scholarly Commons, 2001. https://scholarlycommons.pacific.edu/uop_etds/2733.

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The objective of this research was to investigate two important aspects of buccal drug delivery, transport and mucoadhesion. Buspirone was chosen as a model drug for the in vitro buccal transport studies, polyvinyl alcohol and sodium alginate polymer blends were prepared to investigate the mucoadhesive properties through a Lewis acid-base approach and finally, the effect of formulation factors on the force of mucoadhesion, surface energy parameters, release rate and flux was studied. In vitro permeation studies were conducted to investigate the buccal transport pathway of buspirone. Mathematic

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30

Jørgensen, Lene. "Lipid based drug delivery systems for parenteral delivery of proteins /." Cph. : Department of Pharmaceutics, the Danish University of Pharmaceutical Sciences, 2004. http://www.dfh.dk/phd/defences/lenejoergensen.htm.

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31

Mualem-Burstein, Odelia Wheatley Margaret A. "Drug loading onto polymeric contrast agents for ultrasound drug delivery /." Philadelphia, Pa. : Drexel University, 2008. http://hdl.handle.net/1860/2811.

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32

Redhead, Helen Margaret. "Drug loading of biodegradable nanoparticles for site specific drug delivery." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338495.

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33

Sy, Jay Christopher. "Novel strategies for cardiac drug delivery." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/39531.

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The American Heart Association (AHA) estimates that at least one American will die from a coronary event every minute, costing over $150 billion in 2008 alone. Regenerating the myocardium of patients that survive the initial infarction has proven to be an elusive goal. A variety of factors - including the loss of contractile cells, inflammatory response following infarction, cardiac hypertrophy, and lack of suitable cues for progenitor cells - causes fibrosis in the heart and loss of cardiac function. This dissertation examines three drug delivery strategies aimed at improving conditions fo

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34

Qin, Jian. "Environment-Sensitive Multifunctional Drug Delivery Systems." Doctoral thesis, KTH, Funktionella material, FNM, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-12053.

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Drug delivery systems (DDS) with multiple functionalities such as environment-sensitive drug release mechanisms and visualization agents have motivated the biomedical community as well as materials chemists for more than a decade. This dissertation is concerned with the development of nanoparticles for multifunctional DDS to tackle several crucial challenges in these complex systems, including polymeric nanospheres which respond to temperature change, superparamagnetic iron oxide nanoparticles/polymeric composite for magnetic resonance imaging contrast agents and drug carriers, immunoresponse

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35

Henry, Sʹebastien. "Microfabricated device for transdermal drug delivery." Thesis, Georgia Institute of Technology, 1997. http://hdl.handle.net/1853/20707.

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36

McAllister, Devin Vincent. "Microfabricated needles for transdermal drug delivery." Diss., Georgia Institute of Technology, 2000. http://hdl.handle.net/1853/11031.

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37

Guan, Jingjiao. "Microfabricated particulate devices for drug delivery." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1118247862.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xxiii, 163 p.; also includes graphics. Includes bibliographical references (p. 118-123). Available online via OhioLINK's ETD Center

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38

Qin, Jian. "Nanoparticles for multifunctional drug delivery systems." Licentiate thesis, Stockholm : Kemi, Kungliga Tekniska högskolan, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4369.

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39

Santos, Paulo Antonio Fernandes Gomes. "Transdermal drug delivery using spray formulations." Thesis, University College London (University of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497653.

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40

Albasarah, Yaqoub Yousif. "Colloidal carriers for nebulized drug delivery." Thesis, University of London, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553758.

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Objectives: To explore the potential of liposomes, chitosan-coated liposomes and chitosan complexes for pulmonary delivery of hydrophilic and hydrophobic materials using medical nebulizers. Methods: Chitosan coated and uncoated liposomal vesicles containing the hydrophobic drug amphotericin B (AmB) or hydrophilic lactate dehydrogenase (LDH) were generated from ethanol-based proliposomes and by thin film hydration. LDH chitosan complexes were prepared using different molecular weights and concentrations of the polymer. The colloidal formulations were assessed for morphology, particle size and s

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41

Alexander, Shirin. "Multi functional polymers for drug delivery." Thesis, University of Bristol, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.566691.

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Amphiphilic block and graft copolymers have been studied because of the possibility of tailoring their complex and fascinating chemical properties. Potential applications include wetting agents, foaming agents, plastic modifiers as well as biomedical applications in drug delivery, owing to their biocompatible and low toxic nature. This thesis describes the study of a series of amphiphilic block copolymers, known as Pluronics, and their aqueous interaction with a hydrophobic drug, flurbiprofen. Synthesis and characterisation of novel graft copolymers with interesting associative behaviour that

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42

Kim, Yoo C. "Targeted drug delivery within the eye." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/52971.

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This work introduces novel approaches to enhance targeting of pharmacotherapies to cornea, ciliary body, choroid, and posterior segment of the eye using microneedles as a drug delivery platform. The first part of the work determines the ability to deliver protein therapeutics into the cornea using coated microneedles to suppress corneal neovascularization in a rabbit model. The data show that highly targeted delivery of the anti-vascular endothelial growth factor protein therapeutic gave a better biological response of suppressing neovascularization with 11,900 times less dosage compared to to

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43

Clark, Andrew Reginald. "Metered atomisation for respiratory drug delivery." Thesis, Loughborough University, 1991. https://dspace.lboro.ac.uk/2134/7313.

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An investigation into the factors affecting the metered atomisation of superheated liquids has been carried out. The investigation was aimed primarily at developing an understanding of the factors which affect the performance of. respiratory drug delivery systems (Suspension Pressurised Metered Dose Inhalers). Initial investigations used a semi-empirical sizing technique, representing the human airways, to identify the major variables (formulation and geometric) which affect the performance of the MDI system. Computer models were developed to describe both continuous and metered discharge from

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44

Long, C. P. "Transdermal drug delivery to the neonate." Thesis, Queen's University Belfast, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269128.

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45

Campbell, K. C. "Novel systems for transdermal drug delivery." Thesis, Queen's University Belfast, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368758.

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46

Lee, Antony James. "Mathematical modelling of drug delivery systems." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309563.

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47

He, Ping. "Chitosan microspheres for controlled drug delivery." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284427.

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48

Davies, Nigel M. "Mucoadhesive polymers in ocular drug delivery." Thesis, Cardiff University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316277.

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49

Mao, Jianwen. "Polyurethane microgels and controlled drug delivery." Thesis, University of Strathclyde, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263035.

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50

Wong, Dennis. "Novel amphiphilic materials for drug delivery." Thesis, University of Strathclyde, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424250.

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